Over 20 million people in the United States have diabetes, a metabolic disorder characterized by the body's lack of production or ineffective use of insulin, and the rate is on the rise. Diabetes can cause acute, as well as long-term complications when not properly controlled. Some of the complications may include coma, cardiovascular disease, renal failure, blindness, nerve damage, vascular damage, and poor healing which can lead to amputation. Though there is no cure for either Type I or Type II diabetes, ongoing effort to develop new drug and gene therapies continues. In the meantime, the goals of treatment are disease management, prevention of complications, and improved quality of life. The choice of therapeutics varies by diabetes type and may depend on other significant factors. The selected regimen often includes medication, injection therapy, exercise and change in diet.
Over the past few decades, awareness of the importance of early diagnosis and treatment of diabetes has increased significantly. With approximately one-third of those affected by diabetes unaware of their illness, it is critical to make every effort to identify the disease early in its course. The primary care physician is frequently the first to see patients presenting with pre-diabetes and diabetes symptoms. This highly practical volume is specifically designed for primary care physicians and internists on the frontlines of care. It provides a clinically-focused roadmap to providing optimal care for patients with pre-diabetes and diabetes, from the initial patient visit through testing, goal-setting and follow-up care. It offers up-to-date information on diagnosis and treatment options for all types of diabetes, helping to expedite delivery of appropriate care.
Part of the new Oxford American Endocrinology Library, this concise yet comprehensive guide covers current approaches and new developments in the diagnosis, management and treatment of diabetes, including Type I, Type II, and gestational diabetes, as well as additional notes on pre-diabetes. The text covers new and emerging pharmacotherapies and complementary treatment guidelines, as well as valuable guidance on managing the major complications of diabetes. In addition to diet and exercise tips for patients, the guide also provides strategies and tools for inspiring healthier lifestyles and patient compliance to reach health goals.

This issue of Medical Clinics devoted to prediabetes and diabetes prevention belongs in the hands of every practicing internist, PCP, hospitalist, nurse practitioner, endocrinologist, and any healthcare provider who is concerned about the diabetes epidemic. The importance of this resides in our ability to prevent diabetes by early identification of individuals with a precursor condition termed prediabetes that affect 54 million adult Americans. This entity has grown globally over the recent decades paralleling the obesity epidemic. No country or region of the world is immune. Overweight and obesity affect approximately 60% of our population and children as well as adolescents are not spared. Approximately 13% of adolescents have prediabetes which has doubled since the year 2000. Both type 2 diabetes and prediabetes are preventable and reversible with lifestyle changes involving weight loss and exercise. This issue gives a historical perspective on diabetes prevention, examines its public health implications, and explores diabetes prevention initiatives. Essential topics covered include prediabetes definition, epidemiology, mechanisms of complications, pathophysiology, diagnosis, and treatment recommendations. Diabetes prevention trials and the economics of prevention are also covered.

The incidence and prevalence of type 2 diabetes mellitus have increased dramatically in modernized and developing nations over the past few decades. Thoroughly revised and expanded, this Second Edition responds to the epidemic and supplies a current overview and guide to the management of diabetes in the modern healthcare environment. This Second Edition offers a current perspective on diabetes demographics, epidemiology, pathophysiology, disease monitoring, and approaches to glucose control, and supplies new chapters by world-renowned experts on non-pharmacological management options, complications of the skin and urogenital function, related macrovascular conditions, coronary heart disease, stroke, and peripheral vascular disease, and rare forms of diabetes, PCOS, and NASH.

From America's most trusted health authority, this is the ultimate guide to managing Type 2 diabetes. Diabetes is a leading cause of death and disability in the U.S., and in recent years the disease has reached epidemic levels: nearly 19 million Americans now live with Type 2 diabetes and 13 million more are affected by its precursor, prediabetes. Now, at last, America's leading group of medical experts has created an easy-to-understand self-care reference to help people prevent and manage the disease. Authoritative and up to date, the book explains what diabetes is, describes its risk factors, and offers practical strategies for reducing those risks including improving nutrition, exercising more, and losing weight. For people who are currently living with diabetes, it offers comprehensive, helpful information about recommended lifestyle changes, blood-glucose testing, medications, alternative and complementary therapies, and how to prevent serious complications.Complete with special sections on gestational diabetes and the increasing numbers of American children who are at risk of developing Type 2 diabetes or who are living with it, this guide is an essential home reference for everyone with diabetes or prediabetes. The American Medical Association has been the leading group of medical experts in the United States and one of the most respected health-related organizations in the world for more than 150 years. Previous AMA books include the more than 2 million-copy bestseller, American Medical Association Family Medical Guide, now in its fourth edition (0-471-26911-5). Boyd E. Metzger, MD (Chicago, IL) is the Tom D. Spies Professor of Metabolism and Nutrition in the Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine at Northwestern University, Feinberg School of Medicine, and Attending Physician at Northwestern Memorial Hospital in Chicago. He headed Northwestern University's Clinical Center for the Type 2 Diabetes Prevention Program funded by the National Institute of Health

In this pocket version of his bestselling Life Without Diabetes, Professor Roy Taylor offers a brilliantly concise explanation of what happens to us when we get type 2 and how we can escape it.

Taylor's research has demonstrated that type 2 is caused by just one factor - too much internal fat in the liver and pancreas - and that to reverse it you need to strip this harmful internal fat out with rapid weight loss.

In simple, accessible language, Taylor takes you through the three steps of his clinically proven Newcastle weight loss plan and shows how to incorporate the programme into your life.

Complete with FAQs and inspirational tips from his trial participants, this is an essential read for anyone who has been given a diagnosis of type 2 diabetes or pre-diabetes and wants to understand their condition and transform their outcomes.

The management of diabetes in children and young people continues to develop in important areas, including self-monitoring, insulin delivery, dietary prescription, concept of control and the early identification of complications. Meanwhile responsibility for care has become a partnership between patients, parents and a multi-disciplinary team of health professionals. Key features of Childhood and Adolescent Diabetes include:

• Stand-alone chapters offering practical solutions to problems confronting children, young people and their parents
• Rational advice on monitoring and managing diabetic complications
• Guidance on the involvement of families, schools and teachers
• Discussion of the psychological aspects
• Recommendations on setting standards of care, audit, data-handling and registration
• Suggestions for setting up and running activities beyond the clinic

As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes. The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease. Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.

The enormous increase in our knowledge and understanding of diabetes mellitus in recent years has resulted in new management strategies for greatly enhancing care in diabetic pregnancy. Clinicians responsible for the care of women with diabetes need to keep abreast of these advances. Diabetes and Pregnancy: An International Approach to Diagnosis and Management is a comprehensive, yet practical guide to the present state of knowledge regarding diabetic pregnancy. It summarizes published literature, and offers clear and valuable information on the practicalities of providing special care before, during and after pregnancy. This volume will be indispensable to all members of the health care team involved in the care of pregnant diabetic women and their babies, including obstetricians, neonatologists, diabetes physicians, specialist nurses, midwives as well as general practitioners.

Dealing with Diabetes Burnout: How to Recharge and Get Back on Track When You Feel Frustrated and Overwhelmed Living with Diabetes is an inspiring and empowering guide to managing the daily work and pressure of diabetes management - counting carbohydrates at every meal, constantly adjusting medication doses, taking daily injections, pricking fingers multiple times a day, and struggling with the unavoidable challenges of fancy, yet imperfect, technology - that can lead to burnout. Vieira provides the tools and encouragement needed to help readers get back on track and make diabetes management a rewarding priority. Chapters directly address burnout in relation to: food, exercise, insulin dosing, blood sugar checking, fear of low blood sugar, being a caregiver/spouse of a person with diabetes, communicating more effectively with your doctor, taking a healthy ""vacation"" from diabetes, and creating realistic expectations and goals.

Self-manage digestive disorders through dietary choices

Suffering from a gastrointestinal disorder–whether it’s irritable bowel syndrome, gas, constipation, heartburn, or another condition–can be embarrassing and debilitating. While medical treatments and prescriptions can offer relief, one of the most important ways you can help yourself is to choose the right foods to eat.

Backed by the American Dietetic Association, this user-friendly guide shows you how to analyze your eating habits so that you can map out a dietary plan to manage and reduce the uncomfortable symptoms of digestive disorders. You’ll find practical recommendations for implementing changes in your lifestyle and advice on steering clear of common dietary mistakes. Your meals will be pleasurable and nourishing experiences–not painful ones–when you discover how to make the best and most comfortable food choices so you can embark on the road to digestive health.

The definitive guide to eating well and staying healthy with diabetes

"Nutrition is pivotal to diabetes care. This book is a terrific tool for managing diabetes through good nutrition. It’s a guide you can use every day–a treasure chest of advice on how to eat healthfully."
–Richard M. Bergenstal, MD, Executive Director
International Diabetes Center, Minneapolis, Minnesota

From the American Dietetic Association comes this authoritative guide to choosing foods to control your blood sugar and maintain an active, healthy lifestyle. It provides the must-know basics of daily diabetes care–from designing a food plan and preventing low blood glucose levels to losing weight and carbohydrate counting–so you can personalize diabetes and food decisions to fit your needs. You’ll see how to manage blood fat levels and blood pressure–an important part of diabetes care–and gain invaluable insight into making healthy food choices and planning tasty meals. You’ll also find tips on reducing sugar and fat in foods; quick and easy meal ideas; and a special section on prevention of type 2 diabetes.

• Detailed menu plans for daily caloric levels of 1,200, 1,500, 1,800, 2,000, and 2,500 calories
• Includes fast-food restaurant and ethnic food guides
• Ratings for high, low, and moderate glycemic index foods

A simple new dietary approach to preventing and treating diabetes

You can help prevent and control diabetes through simple diet and lifestyle changes that are a pleasure to make instead of a chore. This book shows you how. Drawing on the latest diabetes research, Healthy Eating for Life to Prevent and Treat Diabetes presents a complete and sensible plant-based nutrition program that can help you prevent, manage, and, in certain cases, even reverse diabetes.

Covering Type 1(childhood-onset), Type 2 (adult-onset), and gestational diabetes, this book provides detailed nutritional guidelines that have been carefully drafted by Physicians Committee diabetes experts, along with nearly 100 delicious, easy-to-make recipes to help you put these healthy eating principles to work right away. Healthy Eating for Life to Prevent and Treat Diabetes contains important information on:

• Exercise and lifestyle issues
• Achieving and maintaining healthy weight
• Diabetes and pregnancy
• Preventing complications from diabetes
• And more

Whether you or a loved one has diabetes or is at risk of developing it, this book will give you the crucial knowledge you need to take charge now–of your diet, your health, and your life.

Also available:

Healthy Eating for Life to Prevent and Treat Cancer (0-471-43597-X)
Healthy Eating for Life for Children (0-471-43621-6)
Healthy Eating for Life for Women (0-471-43596-1)

With the increasing incidence of Type 2 diabetes in the adult population and the realization that this is a vascular disease and a major coronary risk factor, Professor Betteridge has chosen fifty diabetologists to contribute a case which has had an effect on their clinical practice. Both Types 1 and 2 diabetes are included, along with other forms of diabetes, eg gestational. Each case is presented in the same format. The various cases are informative and educational and should provide the reader with a sounder knowledge of patient and disease types.

This empirically based book focuses on typical stressors, individual and family coping strategies, and psychosocial consequences associated with diabetes. Numerous case studies illustrate the difficulty of balancing normative development and adherence to the therapeutic regimen. The combination of theory, research, and practice guarantee the appeal of this book to an international audience of advanced undergraduate and postgraduate students and professionals in developmental and clinical psychology, pediatric medicine and other healthcare professionals concerned with the care of chronically ill adolescents.

Prevention and Recovery from Eating Disorders in Type 1 Diabetes: Injecting Hope sheds light on an often overlooked and misunderstood issue: the problem of eating disorders in women with type 1 diabetes - referred to by lay people and the media as "diabulimia" and characterized by insulin restriction as a means of calorie purging for weight loss. Drawing on a series of recent interviews and over 16 years of research and clinical experience with this unique phenomenon, author Dr. Ann Goebel-Fabbri provides groundbreaking insight into the lives of women who have recovered from eating disorders in type 1 diabetes. She explores the condition's origins, its effects on the lives of those affected, and possible paths to recovery. Also included are suggestions for prevention and treatment, as well as practical and inspirational advice from now-recovered women. Prevention and Recovery from Eating Disorders in Type 1 Diabetes is a valuable guide for patients and loved ones, diabetes treatment teams, and eating disorder clinicians.

Don't just survive - thrive! That's the message of this state-of-the-art guide to diabetes management. From causes, symptoms and side effects to treatments and diet, this book will help British diabetics understand all types of diabetes and delivers sound advice on staying fit and feeling great. The best-selling second edition has been updated to cover key information on managing pre-diabetes, plus new content on screening tests, medications and lifestyle advice. With additional information on the latest advances in therapy for diabetes and its complications, this new edition will make sure you're covered from every aspect.

You can feel great again!

"Syndrome X proactively lays out a nutritious, tasty, and simple diet plan to get us back to the basics of healthy nutrition."–Lendon H. Smith, M.D., New York Times bestselling author of Feed Your Body Right

"Syndrome X is the best new book to help you understand the facts about nutrition, health, and aging. . . . It is full of new information and insights most readers have never had access to before. Everyone who values his or her health will want to read the book and then individualize the program to suit his or her needs–the authors have made this easier than ever to do."–Richard A. Kunin, M.D., author of Mega-Nutrition

What is Syndrome X? It’s a resistance to insulin–the hormone needed to burn food for energy–combined with high cholesterol or triglycerides, high blood pressure, or too much body fat. Syndrome X ages you prematurely and significantly increases your risk of heart disease, hypertension, obesity, eye disease, nervous system disorders, diabetes, Alzheimer’s, cancer, and other age-related diseases.

Syndrome X is the first book to tell you how to fight the epidemic disorder that is derailing the health of nearly a third of North Americans. It outlines a complete three-step program–including easy-to-follow diets, light physical activity, and readily available vitamins and nutritional supplements–that will safeguard you against developing Syndrome X or reverse it if you already have it.

As seen on ITV's Save Money: Lose Weight 'I've got this book and it's fantastic' Tom Watson, former Deputy Leader of the Labour Party 'an inspiring recipe book' Daily Mail 'The food has been filling and quite simple to make... I'm not missing anything. I am satisfied.' Sharon, tester on ITV's Save Money: Lose Weight 'I believe we have eaten our way into this epidemic of diabetes and obesity and that we can eat our way out of it' Dr David Unwin from his Foreword In 2012 Giancarlo Caldesi was diagnosed with type 2 diabetes. Since adopting a low-carb diet he has lost almost 4 stone and put his diabetes into remission - transforming his and his family's health. Working with nutritionist Jenny Phillips, Giancarlo and his wife Katie show you how to enjoy a low carb but not no-carb way of life with simple recipes using easy-to-source ingredients that will fill you up without fattening you up. Steak and Chips are still on the menu, as are delicious curries such as Butter Chicken and Spinach Paneer, even puddings like Hot Chocolate Pots or Peanut Butter & Jelly Cake. An initial diagnosis of diabetes can be shocking and the masses of information daunting, but Katie and Giancarlo share their personal experience of diabetes and weight loss to empower you to make your own informed decisions about food, without sacrificing any of the flavour.

This book discusses the latest research in the pathophysiology, diagnosis, and screening of diabetes and its management. It reviews novel technologies for early diagnosis and highlights the molecular mechanisms of microvascular and macrovascular complications of diabetes 2 mellitus. The book covers the applications of nanotechnology in diagnostics, monitoring, and treatment of diabetes mellitus. The chapter also presents the latest developments in differentiating pancreatic cells from PSCs and illustrates the challenges of their therapeutic application in treating diabetes. The book also explores the prospective medicinal plants comprising either plant extract or isolated bioactive phytoconstituents bearing anti-diabetic potential, which has been reported in several in vitro, in vivo, or clinical studies. It further examines the major mechanisms involved in cardiovascular complications among type 2 diabetes mellitus individuals and discusses the various pharmacological interventions and agents developed to delay cardiovascular events and thereby the quality and duration of the patients. Towards the end, the book summarizes the potential impact of ketogenic diets on diabetic patients, and the role of genetic vulnerability in diabetic nephropathy. As such, this book is a valuable source for students, researchers, and practitioners working in glucose metabolism, diabetes, and human health.

The indispensable guide to all aspects of clinical care, the Oxford Handbook of Endocrinology and Diabetes has been fully updated for its fourth edition, providing comprehensive coverage of both disciplines in a practical and concise format. Featuring new chapters on transition in endocrinology and diabetes, practical nursing considerations, and the genetics of endocrinology, and expanded sections on inherited endocrine syndromes and MEN, it retains the clear organisation and layout for ease of reference as the previous edition over a broader range of topics. Combining authority, relevance, and reliability, this title includes new therapies and guidelines alongside 'clinical pearl' and 'tricky situation' boxes to aide readers in rare or complicated situations. This is the must-have guide for all trainees and specialist nurses in endocrinology and diabetes.

Diabetes has garnered worldwide attention and research funding as clinicians and researchers seek to better understand its pathogenesis, prevention, complications management, and impact and relationship to other diseases (heart disease, kidney disease, infections, and inflammation). Clinicians are overwhelmed with rapidly evolving developments regarding the science and clinical management of diabetes and are struggling to understand and apply new diabetes information. This book will provide a concise interpretation of translational diabetes research for the purpose of preparing clinicians to understand and effectively deploy new strategies and therapeutics into the clinical care of diabetes patients by examining: the contrast between existing information in the clinical practice versus the basis and need for future clinical trials breakthroughs within clinical trials and methods to incorporate bench to bedside material for the clinical practice the synthesis and interpretation of the scientific principles, trial results, and clinical implications of emerging and translational therapies, and the management strategies for diabetic patients the entire scope of translational diabetes research from biology to screening and prognosis, new therapeutics, insulin, transplantation, and complications management new therapeutic strategies to knowledgeably and effectively equip the practicing clinician assembles information that is scattered throughout the diabetic community into one concise single reference

1. 1 Experimental Diabetes in the Sand Rat 1. 1. 1 Zoology Experimental diabetes has been used in numerous animals, of which rodents have been predominant because of their ease of maintenance and handling (Herberg 1979), but some species of ape and monkey have also occasionally been used (Brunk 1971; Malaisse and Malaisse-Lagae 1970). Herberg et al. (1976) divided rodent species into two groups based on the similarity of their metabolic response to the induction of diabetes to the onset of diabetes mellitus in man. In one of these groups (mouse, Mongolian gerbil, Tuco tuca), the response of the metabolism to the induction of diabetes was similar to the changes seen in the onset of adult-type diabetes mellitus in man; while the other group, which included the sand rat, spiny mouse, Chinese hamster, and Djungarian hamster, responded to diabetes induction in a way suggestive of juvenile insulin-dependent diabetes. Such a subdivision is not without prob lems, however, particularly since difference occur not only between the various species of a group (Herberg et al. 1976), but, in our experience, also between animals of the same species (for instance the sand rat). Hence, the zoology of animals used for experimental purposes must also be taken into account. 1 The sand rat is classified as follows: Species: obesus Genus: Psammomys Subfamily: Gerbillinae Family: Cricetidae Suborder: Myomorpha Order: Rodentia Subclass: Placentalia Class: Mammalia Subphylum: Vertebrata Phylum: Chordata Psammomys obesus was first described by the zoologist P. J."

Diabetes Guide adopts a novel "non-textual" approach to the dissemination ofcomprehensive, up-to-date information on the theory and practice of diabetology. This has been achieved through the liberal use of tables, diagrams, flowsheets, summaries and annotations in place of the usual prose and verbiage. As a result of such an economic use of space, vast amounts of knowledge on the definition, classification, management complications and various other aspects of diabetes have been condensed intoa surprisingly digestible pocketbook. Emerging perspectives on genetic counseling, the insulin gene and pancreatic transplantation are also incorporated. One outstanding feature of Diabetes Guide is the provision of succinct practical recommendations for the solution of problemsthat arise during the daily care of patients with diabetes. The subjects covered under these recommendations range from insulin infuser pump problems, care of foot ulcers, food exchanges, travel and acute illness, insulin allergy and desensitization protocol, diabetic emergencies, pregnancy, surgery, hypoglycaemia, etc. Such breadth of coverage has been achieved without the usual price of increased bulk through the unique "non-Textual" approach. Diabetes Guide is designed to be a user-friendly, ready reference of vade mecum for practical tips and core information on various aspects of diabetes.

Given the rapid increase in the worldwide incidence of gestational diabetes, the need for defining the risks and effects associated with raised glucose concentrations in pregnancy is great. Recent large studies are helping to define the risks, as well as identify the benefits of reducing glucose intolerance. Written by an esteemed list of international authors, Gestational Diabetes: Origins, Complications, and Treatment presents timely reviews relating to some of the most important aspects of gestational diabetes, specifically its causes, consequences, and treatments. Divided into five sections, the book begins with a section on metabolism in pregnancy and gestational diabetes, dealing with maternal and foetal glucose metabolism and the controversial area of what actually constitutes gestational diabetes. The next section examines risk factors and causes of gestational diabetes, including the obvious but often overlooked factors-being female and pregnant. The text also outlines environmental and genetic risk factors. The third section deals with the potential complications of gestational diabetes for both mother and offspring, considering short-term and long-term effects. The largest section in the book addresses treatments in an effort to improve the outcome for the mother and the baby. Chapters describe the nutritional approach, considered the cornerstone of treating gestational diabetes, as well as evidence for the role of exercise in its treatment and a useful strategy for treating gestational diabetes pharmacologically. The final section discusses future prospects in screening, diagnosis, prevention, pathophysiology, and treatment of gestational diabetes.