This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubility in silico and in vitro are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify and control solubility of a drug during the manufacturing process and of the pharmaceutical product are essential practical aspects of this book.

Through a fusion of personal experience and art, the contributors help us understand the lived realities of individuals with head and neck cancer. Featuring original art from Ingrid Bachmann, Sean Caulfield, Jude Griebel, Jill Ho-You, Heather Huston, and Bradley Necyk, this collaborative, interdisciplinary exploration draws together the voices of patients, health care practitioners, researchers, and artists to offer a more holistic-more human-understanding of cancer treatment and its aftermath. Art-Medicine Collaborative Practice will resonate with people with head or neck cancer as well as medical practitioners who aid in their healing process. It is an important book for all those in the health professions and medical humanities, as well as artists, arts-based researchers, and those interested in the areas of health and visual communication and knowledge translation. Contributors: Ingrid Bachmann, Pamela Brett-MacLean, Sean Caulfield, Kimberly Flowers, Jude Griebel, Bahaa Harmouche, Jill Ho-You, Heather Huston, Bernie Krewski, Lianne McTavish, Suresh Nayar, Bradley Necyk, Leslie O'Connor-Parsons, Kyle Terrence, Helen Vallianatos, Minn N. Yoon

The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

The Cerebellum provides a concise, accessible overview of modern data on physiology and function of the cerebellum as it relates to learning, plasticity, and neurodegenerative diseases. Encompassing anatomy and physiology, theoretical work, cellular mechanisms, clinical research, and disorders, the book covers learning and plasticity while introducing the anatomy of the cerebellum. Known and proposed "functions of the cerebellum" are addressed on clinical, physiological, cellular, and computational levels, providing academics, researchers, medical students, and graduate students with an invaluable reference.

Das kindliche Elektroenzephalogramm unterscheidet sich in wesentlichen Punkten vom EEG des Erwachsenen. In jeder Altersgruppe finden sich parallel zur Hirnentwicklung spezifische EEG-Muster, Normvarianten und pathologischen Veranderungen, deren Kenntnis fur die Beurteilung essentiell ist. So gibt es eine Vielzahl altersabhangiger Epilepsieformen und anderer Krankheitsbilder, die im Erwachsenenalter unbekannt sind. Eine besondere Herausforderung stellt die Beurteilung des Neu- und Fruhgeborenen-EEGs dar.

Dieser Leitfaden klart daruber auf, was bei EEG-Ableitungen im Sauglings- und Kleinkindesalter zu berucksichtigen ist und hilft dabei, EEG-Kurven richtig zu interpretieren und pathologische von normalen Mustern abzugrenzen.

Das Buch ist ein unveranderter Nachdruck des gleichnamigen Kapitels aus dem Werk "Klinische Elektroenzephalographie" von Stephan Zschocke und Hans-Christian Hansen. Nutzlich ist es insbesondere fur Kinder- und Jugendarzten und Neurologen, die mit den Grundlagen der Elektroenzephalographie vertraut sind. Einsteigern zum Thema zeigt dieses Buch auf, wo und wann das EEG im Kindesalter einen Beitrag zur Diagnose leisten kann."

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.

Currently, there are major advances in the field of oxidative stress and whether or not it has a role in the pathogenesis of cardiovascular disease. However, much of this knowledge and discussions of oxidative stress have centred on specific issues connected with cardiovascular disease areas such that no clear comprehensive review has been documented or published until this book.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. PreTest is the closest you can get to seeing the USMLE Step 1 before you take it! 500 USMLE-type questions and answers! "This book is a wonderful resource for second year medical students taking pathology as well as medical students in their clinical years. It is a good review and highly relevant to what I am seeing in the hospital." -- Sheree Perron, Third Year Medical Student, Eastern Virginia Medical School "I especially liked how there was a wide range of difficulty with questions. The pictures that accompanied several of the questions were very clear, and represented what students are likely to see on the actual exam." -- Jodie Bachman, Third Year Medical Student, UMDNJ School of Osteopathic Medicine Great for course review and the USMLE Step 1, Pathology: PreTest asks the right questions so you'll know the right answers. You'll find 500 clinical-vignette style questions and answers along with complete explanations of correct and incorrect answers. The content has been reviewed by students who recently passed their exams, so you know you are studying the most relevant and up-to-date material possible. No other study guide targets what you really need to know in order to pass like PreTest! Content that covers all the must-know topics: High-Yield Facts,General Pathology,Cardiovascular System,Hematology,Respiratory System,Head and Neck,Gastrointestinal System,Urinary System,Reproductive Systems,Endrocrine System,Skin,Musculoskeletal System,Nervous System

There is a growing awareness of the important role that human genetics plays in individual differences in human behavior. Human Genetics for the Social Sciences introduces students of the social and behavioral sciences to the basic biological concepts underscoring the study of genetics. Carey explains basic biological concepts while covering principles of genetics, evolution and evolutionary psychology, and the genetics of individual differences. Selective coverage of research in genetics, focusing on areas of most relevance to the social sciences, enables students to appreciate the role of genetics in everyday human behavior. Recommended for social science courses in Human Development, Personality, Psychology, Individual and Family Studies, Human Development, Education, and Sociology.

• Chapter introductions and highlighted key terms aid student comprehension.
• Text boxes explore issues in depth and figures and tables visually augment text discussion.
• Advanced Topics sections present technical issues at the end of selected chapters.
• Suggested Readings at the end of each chapter to guide students to further information.

An accompanying fully interactive web site introduces students to basic principles of genetics, supplying students with quizzes, learning exercises, articles on advanced topics in genetics, as well as links to a variety of related web resources.

Biological Action of Low Doses of Radiation - A Novel View on the Problem

Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.