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Two distinguished scientists encouraged Warwick Collins in writing his revolutionary theory of evolution. Professor Freeman Dyson, one of the world's leading theoretical physicists, wrote, "I like your theory, and think it has a good chance of being right."He added, "Darwin would have liked your theory." Professor Donald Braben, a nuclear physicist who directed a series of wide-ranging research programs at BP, responded, "Hierarchically speaking, variation is of greater significance than selection. I agree, therefore, that if silent gene theory were proved correct, it would be the more complete theory, as Einstein's is compared with Newton's."Charles Darwin wrote in The Origin of Species that ..". unless profitable variations do occur, natural selection can do nothing." As Darwin recognized, natural selection, far from increasing variation within species, reduces variation constantly in favor of an optimum type. What then is the true source of variation in evolutionary systems? It is a question which has obsessed Warwick Collins, a novelist who had studied biology at university, for much of his adult life.He proposed in March 2000 that the required degree of variation could be achieved if large numbers of inert or silent genes existed within the genome. Such genes, because they do not code for physical characteristics, could freely mutate over time without deleteriously affecting the host organism. At a later stage they could be switched on, by largely random processes, and generate exotic new variants. Remarkably, his description of silent genes was found to correspond precisely with the so-called junk genes. These are found in all species, forming the great majority of genes in multicellular species and rising to 98.5% of the genome in humans. Until then their function had proved mysterious. In addition, Collins's theory predicted a number of features of the silent or junk genes which have since been increasingly verified by recent research: for example, that they could become active and begin to code, and that they influenced other genes.It is now widely accepted that, just as Collins predicted, the vast majority of significant mutation in the genomes of complex species arises from the silent genes. But Collins's powerful and ambitious theory moves well beyond the molecular realm. He argues that while natural selection is a major force in evolution, it is primarily negative and entropic. Instead, the great driver of complex evolution is the range of variation created by the silent genes. As Professor Donald Braben writes in his illuminating foreword, "Collins is proposing a general evolutionary theory which, if it continues to be supported by the data, may in due course come to rival Darwin's theory that evolution is driven by natural selection."

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HYDROGEN SULFIDE Covers H2S interactions, methods of detection and delivery in biological environments, and a wide range of applications Research on hydrogen sulfide (H2S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H2S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H2S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities. Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies provides the foundation required for understanding the fundamental chemical biology of H2S while highlighting the compound's therapeutic potential and medicinal applications. This book covers key aspects of H2S chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H2S in biological environments; and the therapeutic and medicinal uses of exogenous H2S delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field. Provides approaches for delivering H2S with relevance to biological and therapeutic applications Describes complex interactions of H2S with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species Summarizes advances in available tools to detect, measure, and modulate H2S levels in biological environments, such as real-time methods for H2S fluorescence imaging in live cell and animal systems Helps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action Includes in-depth case studies of different systems in which H2S plays an important role Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.