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This ready reference discusses different methods for statistically analyzing and validating data created with high-throughput methods. As opposed to other titles, this book focusses on systems approaches, meaning that no single gene or protein forms the basis of the analysis but rather a more or less complex biological network. From a methodological point of view, the well balanced contributions describe a variety of modern supervised and unsupervised statistical methods applied to various large-scale datasets from genomics and genetics experiments. Furthermore, since the availability of sufficient computer power in recent years has shifted attention from parametric to nonparametric methods, the methods presented here make use of such computer-intensive approaches as Bootstrap, Markov Chain Monte Carlo or general resampling methods. Finally, due to the large amount of information available in public databases, a chapter on Bayesian methods is included, which also provides a systematic means to integrate this information. A welcome guide for mathematicians and the medical and basic research communities.
This handbook and ready reference presents a combination of
statistical, information-theoretic, and data analysis methods to
meet the challenge of designing empirical models involving
molecular descriptors within bioinformatics. The topics range from
investigating information processing in chemical and biological
networks to studying statistical and information-theoretic
techniques for analyzing chemical structures to employing data
analysis and machine learning techniques for QSAR/QSPR.
An essential guide to biomolecular and bioanalytical techniques and their applications Biomolecular and Bioanalytical Techniques offers an introduction to, and a basic understanding of, a wide range of biophysical techniques. The text takes an interdisciplinary approach with contributions from a panel of distinguished experts. With a focus on research, the text comprehensively covers a broad selection of topics drawn from contemporary research in the fields of chemistry and biology. Each of the internationally reputed authors has contributed a single chapter on a specific technique. The chapters cover the specific technique's background, theory, principles, technique, methodology, protocol and applications. The text explores the use of a variety of analytical tools to characterise biological samples. The contributors explain how to identify and quantify biochemically important molecules, including small molecules as well as biological macromolecules such as enzymes, antibodies, proteins, peptides and nucleic acids. This book is filled with essential knowledge and explores the skills needed to carry out the research and development roles in academic and industrial laboratories. A technique-focused book that bridges the gap between an introductory text and a book on advanced research methods Provides the necessary background and skills needed to advance the research methods Features a structured approach within each chapter Demonstrates an interdisciplinary approach that serves to develop independent thinking Written for students in chemistry, biological, medical, pharmaceutical, forensic and biophysical sciences, Biomolecular and Bioanalytical Techniques is an in-depth review of the most current biomolecular and bioanalytical techniques in the field.
Context and situation always matter in both human and animal lives. Unique insights can be gleaned from conducting scientific studies from within human communities and animal habitats. Inside Science is a novel treatment of this distinctive mode of fieldwork. Robert E. Kohler illuminates these resident practices through close analyses of classic studies: of Trobriand Islanders, Chicago hobos, corner boys in Boston's North End, Jane Goodall's chimpanzees of the Gombe Stream Reserve, and more. Intensive firsthand observation; a preference for generalizing from observed particulars, rather than from universal principles; and an ultimate framing of their results in narrative form characterize these inside stories from the field. Resident observing takes place across a range of sciences, from anthropology and sociology to primatology, wildlife ecology, and beyond. What makes it special, Kohler argues, is the direct access it affords scientists to the contexts in which their subjects live and act. These scientists understand their subjects not by keeping their distance but by living among them and engaging with them in ways large and small. This approach also demonstrates how science and everyday life--often assumed to be different and separate ways of knowing--are in fact overlapping aspects of the human experience. This story-driven exploration is perfect for historians, sociologists, and philosophers who want to know how scientists go about making robust knowledge of nature and society.
Systems biology is a relatively new biological study field that focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (integration instead of reduction) to study them. Particularly from year 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. Systems biology is the study of the interconnected aspect of molecular, cellular, tissue, whole animal and ecological processes, and comprises mathematical and mechanistic studies of dynamical, mesoscopic, open, spatiotemporally defined, nonlinear, complex systems that are far from thermodynamic equilibrium.Containing a unique selection of new and updated, high-quality articles from the well-known Meyer's Encyclopedia of Molecular Cell Biology and Molecular Medicine, this two-volume handbook is an essential guide for students and researchers wishing to get an overview of the field.
With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.
This fantastic CGP Exam Practice Workbook is the perfect companion for Year 1 & 2 of AQA A-Level Biology. It's packed with ultra-realistic exam questions covering every topic students need to know, including a section of mixed (synoptic) questions. We've added in exam tips throughout to make sure there are no unpleasant surprises in their exams! To round things off there are fully worked answers and mark schemes for every question. For study notes and even more practice don't miss the CGP AQA A-Level Biology Complete Revision & Practice guide (9781789080261).
This book provides a description of mass spectrometry basics, applications and perspectives of the technique. All aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS (with special attention to various methodologies and data interpretation) are included in the book. The book contains a list of key terms for easier and faster understanding of the material. The mass spectrometry language and terminology associated with this technique is rather specific. Therefore, comprehensive explanation of the terms would be necessary for the beginners in the field. The book also states, whenever necessary, that mass spectrometry alone is not a universal tool and such analysis, though very powerful and accurate, should be used in conjunction with other techniques such as NMR, pharmacological tests, structural identification, molecular biology, in order to reveal the true function(s) of the identified molecule. This is crucial for young researchers to fully understand both the power of mass spectrometry and the importance of other complementary methodologies. The text is accompanied by test questions as a help for lecturers.
A majority of evolutionary biologists believe that we now can envision our biological predecessors not the first, but nearly the first, living beings on Earth. "Life from an RNA World" is about these vanished forebears, sketching them in the distant past just as their workings first began to resemble our own. The advances that have made such a pursuit possible are rarely discussed outside of bio-labs. So here, says author Michael Yarus, is an album for interested non-biologists, an introduction to our relatives in deep time, slouching between the first rudimentary life on Earth and the appearance of more complex beings.
The era between, and the focus of Yarus work, is called the RNA world. It is RNA (ribonucleic acid) long believed to be a mere biologic copier and messenger, that offers us this glimpse into our ancient predecessors. To describe early RNA creatures, here called ribocytes or RNA cells, Yarus deploys some basics of molecular biology. He reviews our current understanding of the tree of life, examines the structure of RNA itself, explains the operation of the genetic code, and covers much else all in an effort to reveal a departed biological world across billions of years between its heyday and ours.
Courting controversy among those who question the role of ribocytes citing the chemical fragility of RNA and the uncertainty about the origin of an RNA synthetic apparatus Yarus offers an invaluable vision of early life on Earth. And his book makes that early form of life, our ancestor within, accessible to all of us.
Adopting a novel approach, this book provides a unique "molecular
perspective" on plasmonics, concisely presenting the fundamentals
and applications in a way suitable for beginners entering this hot
field as well as for experienced researchers and
BIOLOGY: ORGANISMS AND ADAPTIONS, International Edition captures your passion and excitement for the living world! The authors build on the connection we all have to nature to inspire you to engage with biology in the same way you do when visiting zoos, aquariums, or just taking a walk in the park. Each chapter uses fascinating organisms such as blue whales, salamanders, and redwood trees to present, organize, and integrate biological concepts. Merging the excitement and passion for living things with an understanding of biological concepts, this highly accessible and practical approach to the study of biology develops scientific literacy and connective thinking.
Exam Board: AQA Level: A-level Subject: Biology First teaching: September 2015 First exam: June 2017 Need more exam practice? Letts will get you through your A-Level exam * Have a go at a complete set of papers * Questions just like the real thing * All the answers at the back
The universe that science reveals to us can seem far outside the comfort zone of the human mind. Subjects near and far open up dizzying vistas, from the infinitesimal to the colossal. Humanity, the unlikely product of uncountable coincidences on unimaginable scales, inhabits a tumultuous universe that extends from our immediate environs to the most distant galaxies and beyond. But when the mind balks at the vertiginous complexity of the universe, science unveils the elegance amid the chaos. In this book, Thomas R. Scott ventures into the known and the unknown to explain our universe and the laws that govern it. The Universe as It Really Is begins with physics and the building blocks of the universe--time, gravity, light, and elementary particles--and chemistry's ability to explain the interactions among them. Scott, with the assistance of James Lawrence Powell, next tours the earth and atmospheric sciences to explain the forces that shape our planet and then takes off for the stars to describe our place in the cosmos. He provides vivid introductions to our collective scientific inheritance, narrating discoveries such as the shape of the atom and the nature of the nucleus or how we use GPS to measure time and what that has to do with relativity. A clear demonstration of the power of scientific reasoning to bring the incomprehensible within our grasp, The Universe as It Really Is gives an engrossing account of just how much we do understand about the world around us.
Please note this title is suitable for any student studying: Exam Board: OCR Level: A Level Year 1 and AS Subject: Biology First teaching: September 2015 First exams: June 2016 Written by curriculum and specification experts, this Student Book supports and extends students through the new course whilst delivering the breadth, depth, and skills needed to succeed in the new AS and beyond.
Bang-up-to-date for the latest OCR A Biology A-level course, this CGP Complete Revision & Practice book is the perfect preparation for those tough Year 2 final exams. Every topic is explained with straightforward study notes, helpful examples and full-colour diagrams. We've included plenty of practice questions and exam style questions (with detailed answers) - plus a section of mixed (synoptic) practice testing different parts of the course. There's even a free Online Edition of the whole book - just use the code printed inside the book to access it on your PC, Mac or tablet. For even more practice don't miss our Year 2 of A-Level Biology Exam Practice Workbook (9781782949183).
With over 22,000 entries, "Henderson's Dictionary of Biology" continues to be an essential reference for students, teachers and researchers within any of the biological sciences. This fifteenth edition has updated and revised many existing definitions, and has included new terms from exciting areas such as bioinformatics, proteomics, and genomics.
Provides deep insight into the concepts and recent developments in the area of supramolecular chemistry in water Written by experts in their respective field, this comprehensive reference covers various aspects of supramolecular chemistry in water?from fundamental aspects to applications. It provides readers with a basic introduction to the current understanding of the properties of water and how they influence molecular recognition, and examines the different receptor types available in water and the types of substrates that can be bound. It also looks at areas to where they can be applied, such as materials, optical sensing, medicinal imaging, and catalysis. Supramolecular Chemistry in Water offers five major sections that address important topics like water properties, molecular recognition, association and aggregation phenomena, optical detection and imaging, and supramolecular catalysis. It covers chemistry and physical chemistry of water; water-mediated molecular recognition; peptide and protein receptors; nucleotide receptors; carbohydrate receptors; and ion receptors. The book also teaches readers all about coordination compounds; self-assembled polymers and gels; foldamers; vesicles and micelles; and surface-modified nanoparticles. In addition, it provides in-depth information on indicators and optical probes, as well as probes for medical imaging. -Covers, in a timely manner, an emerging area in chemistry that is growing more important every day -Addresses topics such as molecular recognition, aggregation, catalysis, and more -Offers comprehensive coverage of everything from fundamental aspects of supramolecular chemistry in water to its applications -Edited by one of the leading international scientists in the field Supramolecular Chemistry in Water is a one-stop-resource for all polymer chemists, catalytic chemists, biochemists, water chemists, and physical chemists involved in this growing area of research.
The Edexcel A level Lab Books support students in completing the A level Core Practical requirements. This lab book includes: all the instructions students need to perform the Core Practicals, consistent with our A level online teaching resources writing frames for students to record their results and reflect on their work CPAC Skills Checklists, so that students can track the practical skills they have learned, in preparation for their exams practical skills practice questions a full set of answers. This lab book is designed to help students to: structure their A level lab work to ensure that they cover the Core Practical assessment criteria track their progress in the development of A level practical skills create a record of all of the Core Practical work they will have completed, in preparation for revision.
Practice makes perfect, which is why CGP has created this fantastic Exam Practice Workbook for OCR A AS-Level (and Year 1 of A-Level) Biology to help students feel confident walking into their exams. There's an enormous variety of ultra-realistic exam questions covering every topic they need to know, including a section of mixed (synoptic) questions. Plus we've added in exam tips throughout to help students gain every mark that's up for grabs! To round things off there are fully worked answers and mark schemes for every question. For study notes and even more practice don't miss the matching CGP OCR A AS-Level (and Year 1 of A-Level) Biology Complete Revision & Practice guide (9781782942863).
"There's no better way to learn Year 2 of the AQA A-Level Biology course than with this new and improved CGP Complete Revision & Practice book. It's perfect for reference throughout the year, and preparing for the final exams! It has straightforward study notes, helpful examples and full-colour diagrams. We've included more challenging exam practice than ever before with plenty of practice questions and exam-style questions (with detailed answers) for every topic - plus a section of mixed (synoptic) practice testing different parts of the course. To round things off there are sections of in-depth advice on Practical Skills and how to pick up top marks in the exams. There's even a free Online Edition of the whole book - just use the code printed inside the book to access it on your PC, Mac or tablet. For even more practice don't miss CGP's Year 2 of A-Level Biology Exam Practice Workbook (9781782949091). "
Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.
Fully updated for the revised CCEA specification (first teaching September 2016). Endorsed by CCEA. It has been subject to a detailed quality assurance process by an independent Biology expert. Contains new colour-coded practical work sections to address the AS3 paper. Provides sample examination questions for each topic. Extremely popular resource. Illustrated in full colour. Bright and clear presentation. The author, Dr James Napier, is a well-known Biology author who, prior to his recent retirement, was vice-principal in a Northern Ireland grammar school.
Offers a diverse, interdisciplinary, and eye-opening view of the future direction of forensic science This one-of-a-kind book is a collection of content from the Past and Current Presidents of the American Academy of Forensic Sciences--providing readers with all of their forensic science experience, knowledge, insight, and wisdom. It envisions where forensic science will be a decade from now and the impact of these emerging advances on the law (along with our place in it), emphasizing theoretical advances, innovative leads from the laboratory, and emerging technologies. Filled with information from some of the greatest forensic minds of their generation, The Future of Forensic Science covers all of the eleven sections that comprise the AAFS. It discusses new directions in forensic anthropology, and looks at the future of such disciplines as criminalistics, forensic engineering science, forensic psychiatry and behavioral science, forensic toxicology, and forensic document examination. It also touches on the current and future state of digital and multimedia sciences. Contains contributions from an eminent group of forensic science experts Presents a valuable repository of forensic science experience, knowledge, insight, and wisdom Offers an insightful interdisciplinary look at the future of forensic science and how it is changing forensic science for the better Timed to coincide with the NIST forensic science initiative and the OSAC process The Future of Forensic Science is a must-have book for practicing forensic science professionals, academics, and advanced undergraduate and graduate students in forensic science. This book is published as part of the AAFS series 'Forensic Science in Focus'.
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