The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle.

This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.

Kompakt und "verdammt clever" auf den Punkt gebracht vermittelt Genetik das unverzichtbare molekulare Grundwissen sowie alles Wichtige zu den Themen Genome, Mechanismen der Vererbung, Humangenetik, Populationsgenetik und Evolution sowie zu den Anwendungen der modernen Genetik. Das ideale Einsteiger-Buch verstandlicher Text, einpragsame Abbildungen und prazise Kapitelzusammenfassungen sind echte Pluspunkte, wenn es um einen schnellen Start in dieses spannende Fach geht. Das perfekte Kurzlehrbuch! Optimal fur eine Einfuhrung in die molekulare Genetik die wirklich wichtigen Themen werden mit ihren Kernaussagen kurz und knapp behandelt. Verstandliche Darstellung! Jedes Kapitel enthalt eine Zusammenfassung der wesentlichen Fakten und Begriffe, klare und leicht erfassbare Abbildungen illustrieren die Inhalte. Ohne Angst in die Prufung! Der Textaufbau ermoglicht strukturiertes Lernen und schnelles Wiederholen zusatzlich mit uber 70 Fragen und Antworten zum Uben.

Providing definitions, clinical features and epidemiology, "Sepsis and Non-infectious Systemic Inflammation" adopts a comprehensive approach, describing in detail the various physiological systems involved. As such, this unique handbook and reference work is the first to combine sepsis and non-infectious SIRS, reviewing both the biological and medical aspects of these two important syndromes. The whole is rounded off with a discussion of past, present and future therapies.

"Pharmacology for the Health Care Professions" is an accessible introduction to the pharmacology necessary for health care professionals training to be non-medical prescribers looking for an overview of the subject. The book covers the pharmacology necessary for accredited training programmes in non-medical prescribing and certification in access and supply of prescription-only medicines and will be useful as an ongoing reference for future use in practice.

Opening with a general introduction to pharmacology as a science, the book goes on to explain what is meant by drugs and medicines and why pharmacology should be of relevance to health care professionals. The reader is presented with general principles of pharmacology followed by systemic pharmacology that covers the actions of important groups of drugs in common use to treat diseases and conditions of the cardiovascular, respiratory, endocrine, musculoskeletal, skin and central nervous systems. The physiology and pathophysiology relevant to the understanding of how these drugs work is included.

Finally the book explores the law in relation to the sale, supply, administration and prescription of drugs and explains what is meant by non-medical prescribing. All aspects of non-medical prescribing are considered including the use of exemptions to the Medicines Act, patient group directions, supplementary prescribing and the development of independent prescribing for nurses and pharmacists.

Pharmacology is explained in simple, easy to understand terms and the book avoids any unnecessary chemistry where possible. Case studies that are of particular relevance to health care professionals are used throughout to illustrate theimportance of the pharmacology major body systems and pathologies and the potential problems of adverse drug reactions and drug-drug interactions.

The Proceedings describe the current state of research dealing with biological shape analysis. The quantitative analysis of the shape of biological organisms represents a challenge that has now seen breakthroughs with new methodologies such as elliptical Fourier analysis, quantitative trait loci analysis (QTLs), chromosome segment substitution lines (CSSLs), thin plate splines, etc. The Proceedings also illustrate the diversity of disciplines that are actively involved in the characterization and analysis of biological shape. Moreover, many of the papers focus on the relationship of the shape to the processes that determine the biological form, an issue of major continuing concern in biology.

This new handbook covers the world of biophotonics not only geographically -- with the editors coming from different continents -- but also in terms of content, since the authors come from the whole spectrum of biophotonic basic and applied research. Designed to set the standard for the scientific community, these three volumes break new ground by providing readers with the physics basics as well as the biological and medical background, together with detailed reports on recent technical advances. The Handbook also adopts an application-related approach, starting with the application and then citing the various tools to solve the scientific task, making it of particular value to medical doctors.
Divided into several sections, the first part offers introductory chapters on the different fields of research, with subsequent parts focusing on the applications and techniques in various fields of industry and research. The result is a handy source for scientists seeking the basics in a condensed form, and equally a reference for quickly gathering the knowledge from neighboring disciplines.
Absolutely invaluable for biophotonic scientists in their daily work.

This is an avant-garde book edited by Nobel Laureate Ahmed Zewail with contributions from eminent scientists including four Nobel prize winners. The perspectives of these world leaders in physics, chemistry, and biology define potential new frontiers at the interface of disciplines and including physical, systems, and synthetic biology. This book brings about the confluence of concepts and tools, and that of different disciplines, to address significant problems of our time: visualization; theory and computation for complexity; macromolecular function, protein folding and misfolding; and systems integration from cells to consciousness. The scope of tools is wide-ranging, spanning imaging, crystallography, microfluidics, single-molecule spectroscopy, and synthetic probe targeting. Concepts such as dynamic self-assembly, molecular recognition, non-canonical amino acids, and others are covered in various chapters as they are cornerstones in building the trilogy description of behavior-structure, dynamics, and function. The volume is uniquely structured to provide overviews with historical perspectives on the evolution of ideas and on the future of physical biology and biological complexity, from atoms to medicine.

Agent-based modeling is a new technique for understanding how the dynamics of biological, social, and other complex systems arise from the characteristics and behaviors of the agents making up these systems. This innovative textbook gives students and scientists the skills to design, implement, and analyze agent-based models. It starts with the fundamentals of modeling and provides an introduction to NetLogo, an easy-to-use, free, and powerful software platform. Nine chapters then each introduce an important modeling concept and show how to implement it using NetLogo. The book goes on to present strategies for finding the right level of model complexity and developing theory for agent behavior, and for analyzing and learning from models. Agent-Based and Individual-Based Modeling features concise and accessible text, numerous examples, and exercises using small but scientific models. The emphasis throughout is on analysis--such as software testing, theory development, robustness analysis, and understanding full models--and on design issues like optimizing model structure and finding good parameter values. * The first hands-on introduction to agent-based modeling, from conceptual design to computer implementation to parameterization and analysis* Provides an introduction to NetLogo with nine chapters introducing an important modeling concept and showing how to implement it using NetLogo * Filled with examples and exercises, with updates and supplementary materials at http://www.railsback-grimm-abm-book.com/ * Designed for students and researchers across the biological and social sciences * Written by leading practitioners Leading universities that have adopted this book include: * Amherst College * Brigham Young University * Carnegie Mellon University* Cornell University * Miami University * Northwestern University * Old Dominion University * Portland State University * Rhodes College * Susquehanna University * University College, Dublin * University of Arizona* University of British Columbia* University of Michigan * University of South Florida* University of Texas at Austin * University of Virginia

Systemic Treatment of Incest is the first book to take as its primary focus the treatment of incest families. The authors, who have spent a total of 25 years working with incest families, believe that therapy can succeed in halting the abuse without dissolving the family unit. The volume's three sections are based on the authors' three stages of therapy: creating a context for change; challenging behaviors, expanding alternatives; and consolidation. First published in 1990. Routledge is an imprint of Taylor & Francis, an informa company.

A scholarly collection of timely essays on the behavioral science of peace With contributions from experts representing a wide variety of scholarly fields (behavioral and social sciences, philosophy, environmental science, anthropology and economics), Peace Ethology offers original essays on the most recent research and findings on the topic of the behavioral science of peace. This much-needed volume includes writings that examine four main areas of study: the proximate causation of peace, the developmental aspects of peace, the function and systems of peace and the evolution of peace. The popular belief persists that, by nature, humans are not pre-disposed to peace. However, archeological and paleontological evidence reveals that the vast majority of our time as a species has been spent in small hunter-gatherer bands that are basically peaceful and egalitarian in nature. The text also reveals that most of the earth's people are living in more peaceful societies than in centuries past. This hopeful compendium of essays: Contains writings from noted experts from a variety of academic studies Offers a social-psychological perspective on the causation of peaceful behavior Includes information on children's peacekeeping and peacemaking Presents ideas for overcoming social tension between police and civilians Provides the most recent thinking on the behavioral science of peace Written for students and academics of the behavioral and social sciences, Peace Ethology offers scholarly essays on the development, nature, and current state of peace.

The Flora is prepared at the Royal Botanic Gardens, Kew in close collaboration with East African Herbarium and in liaison with the University of Dar es Salaam, the University of Nairobi and the Makerere University. Significant contributions are also made by specialists elsewhere. This reference should be of use to anyone concerned with the identification and utilization of plants in eastern Africa.

In the new edition of BIOLOGY: CONCEPTS AND APPLICATIONS, authors Cecie Starr, Christine A. Evers, and Lisa Starr have partnered with the National Geographic Society to develop a text designed to engage and inspire. This trendsetting text introduces the key concepts of biology to non-biology majors using clear explanations and unparalleled visuals. While mastering core concepts, each chapter challenges students to question what they read and apply the concepts learned, providing students with the critical thinking skills and science knowledge they need in life. Renowned for its writing style the new edition is enhanced with exclusive content from the National Geographic Society, including over 200 new photos and illustrations. New People Matter sections in most chapters profile National Geographic Explorers and Grantees who are making significant contributions in their field, showing students how concepts in the chapter are being applied in biological research. Each chapter concludes with an `Application' section highlighting real-world uses of biology and helping students make connections to chapter content.

"An extraordinary book. . . . With clarity and charm [Dunn] takes the reader into the overlap of medicine, ecology, and evolutionary biology to reveal an important domain of the human condition."-Edward O. Wilson, author of Anthill and The Future of Life Biologist Rob Dunn reveals the crucial influence that other species have upon our health, our well being, and our world in The Wild Life of Our Bodies-a fascinating tour through the hidden truths of nature and codependence. Dunn illuminates the nuanced, often imperceptible relationships that exist between homo sapiens and other species, relationships that underpin humanity's ability to thrive and prosper in every circumstance. Readers of Michael Pollan's The Omnivore's Dilemma will be enthralled by Dunn's powerful, lucid exploration of the role that humankind plays within the greater web of life on Earth.

This unprecedented book offers all the details of the mathematical mechanics underlying modern modeling of skeletal muscle contraction. The aim is to provide an integrated vision of mathematics, physics, chemistry and biology for this one understanding. The method is to take advantage of latest mathematical technologies -- Eilenberg-Mac Lane category theory, Robinson infinitesimal calculus and Kolmogorov probability theory -- to explicate Particle Mechanics, The Theory of Substances (categorical thermodynamics), and computer simulation using a diagram-based parallel programming language (stochastic timing machinery). Proofs rely almost entirely on algebraic calculations without set theory. Metaphors and analogies, and distinctions between representational pictures, mental model drawings, and mathematical diagrams are offered. AP level high school calculus students, high school science teachers, undergraduates and graduate college students, and researchers in mathematics, physics, chemistry, and biology may use this integrated publication to broaden their perspective on science, and to experience the precision that mathematical mechanics brings to understanding the molecular mechanism vital for nearly all animal behavior.

"Biological Diversity" takes a fresh, innovative approach to the teaching of biodiversity. Rather than detailing and cataloguing the major taxa and their evolutionary relationships, the authors have selected 18 groups of organisms and used these as a framework in which to discuss the species and their interactions with man and each other. There is a strong narrative theme throughout - the exploited and the exploiters - and, in many cases, there is emphasis on the historical context. A wide range of organisms are covered, from the unicellular to birds and mammals and with an equal consideration of plants and animals. Species have been chosen for their ability to best illustrate particular biological principles, and for their strong interaction with other species.

After an introduction the book is divided into two parts: 'Exploited' and 'Exploiters'. Each of the chapters, although linked to each other, forms a stand-alone essay. They are scientifically rigorous, up-to-date and do not shy away from addressing some controversial issues. Chapters have' text boxes' highlighting important issues and concepts, lists of further reading and references. In addition to tables and figures the book has a selection of original illustrations drawn by leading artist Steven Appleby.

This fresh approach will appeal to all those interested in the biological sciences, and aims to be accessible to people with a diversity of backgrounds. It will prove particularly useful to biology students, enabling them to get to grips with important biological principles and concepts that underpin the diversity of life, and the interrelationship of humans with other groups of organisms.