Get submerged in the amazing world of sharks! Your expert host, award-winning marine biologist Dr. David Shiffman, will show you how-and why-we should protect these mysterious, misunderstood guardians of the ocean. Sharks are some of the most fascinating, most ecologically important, most threatened, and most misunderstood animals on Earth. More often feared than revered, their role as predators of the deep have earned them a reputation as a major threat to humans. But the truth is that sharks are not a danger to us-they're in danger from us. In Why Sharks Matter, marine conservation biologist Dr. David Shiffman explains why it's crucial that we overcome our misconceptions and rise above cinematic jump scares to embrace sharks as the imperiled and elegant ocean guardians they really are. Sharing his own fascinating experiences working with sharks, Shiffman tells us * why healthy shark populations are a must for supporting ocean ecosystems-and the coastal economies that depend on them * why we're in danger of losing many shark species forever * what scientists, conservationists, and readers can do to help save these iconic predators * why so much of what you've heard about sharks and how to save them is wrong Exploring the core tenets of shark conservation science and policy, Shiffman synthesizes decades of scientific research and policymaking, weaving it into a narrative full of humor and adventure. Touching on everything from Shark Week to shark fin soup, overfishing to marine sanctuaries, Shiffman reveals why sharks are in trouble, why we should care, and how we can save them. Perfect for shark enthusiasts, Why Sharks Matter is an approachable, informative guide to the world of shark conservation and the passionate, fascinating, brilliant people who work to understand and protect our oceans. This fun read will have you looking at sharks with a fresh perspective and an understanding that the survival of sharks is crucial to the survival of another apex predator-ourselves.

Endorsed by WJEC, this Study and Revision Guide offers you high quality support you can trust. Written by an experienced teacher and examiner, it provides essential underpinning knowledge to recap and revise as well as supporting the development of skills you need to correctly interpret and answer the new exam questions. / An exam practice and technique section offers advice on how exam questions are set and marked. / Plenty of practice questions are included with teacher commentaries. / Grade boost tips help refine exam technique, improve grades and avoid common mistakes. / Numerous diagrams clearly explain each concept. / Pointers focus on understanding and using the underpinning knowledge. / Key terms are clearly defined on each page. / Quickfire questions check and reinforce your understanding.

This comprehensively revised second edition of "Computational Systems Biology" discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling.
Logical information flow aids understanding of basic building blocks of life through disease phenotypesEvolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patternsCoverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computationMulti-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

Pulmonary hypertension is a life-threatening disease with no known cure. Here we provide a concise yet comprehensive review of the current knowledge about the pathophysiology of pulmonary hypertension (PH). The underlying signaling mechanisms involved in pulmonary vascular remodeling and the exaggerated vascular contractility, two characteristic features of pulmonary hypertension, are discussed in depth. The roles of inflammation, immunity, and right ventricular function in the pathobiology of pulmonary hypertension are discussed. The epidemiology of the five groups of pulmonary hypertension (World Health Organization classification; Nice, 2013) is also briefly described. A clear understanding of our current knowledge about the pathogenesis of PH is essential for further exploration of the underlying mechanisms involved in this disease and for the development of new therapeutic modalities. This book should be of interest to researchers and graduate students, both in basic research and in clinical settings, in the fields of pulmonary vascular biology and pulmonary hypertension.