During the past decades, enormous progress and enhancement of pharmaceutical manufacturing equipment and its use have been made. And while there are support documents, books, articles, and online resources available on the principles of cleaning and associated processing techniques, none of them provides a single database with convenient, ready-to-use training tools. Until now. Cleaning Validation Manual: A Comprehensive Guide for the Pharmaceutical and Biotechnology Industries elucidates how to train the man power involved in development, manufacturing, auditing, and validation of bio pharmaceuticals on a pilot scale, leading to scale-up production. With over 20 easy-to-use template protocols for cleaning validation of extensively used equipments, this book provides technical solutions to assist in fulfilling the training needs of finished pharmaceutical manufacturers. Drawing on the authors' more than two decades of experience in the pharmaceutical and biotech industries, the text offers hands-on training based on current approaches and techniques. The book does not merely provide guidelines or thought processes, rather it gives ready-to-use formulas to develop Master Plan, SOPs, and validation protocols. It includes cleaning procedures for the most commonly used equipment in various manufacturing areas and their sampling points, using a pharmaceutical manufacturing site with both sterile and non-sterile operations as the case facility. It also provides the training guidelines on downloadable resources to enable users to amend or adopt them as necessary. Grounded in practicality, the book's applicability and accessibility set it apart. It can be used as a guide for implementing a cleaning validation program on site without the help of external consultants, making it a resource that will not be found collecting dust on a shelf, but rather, referred to again and again.

On Friday, October 16, 1846, only one operation was scheduled at Massachusetts General Hospital....

That day in Boston, the operation was the routine removal of a growth from a man's neck. But one thing would not be routine: instead of using pulleys, hooks, and belts to subdue a patient writhing in pain, this crucial operation would be the first performed under a general anesthetic. No one knew whether the secret concoction would work. Some even feared it might kill the patient.

This engrossing book chronicles what happened that day and during its dramatic aftermath. In a vivid history that is stranger than fiction, Ether Day tells the story of the three men who converged to invent the first anesthesia -- and the war of ego and greed that soon sent all three men spiraling wildly out of control.

Written specifically for biotechnology scientists, engineers, and quality professionals, this book describes and demonstrates the proper application of statistical methods throughout Chemistry, Manufacturing, and Controls (CMC). Filled with case studies, examples, and easy-to-follow explanations of how to perform statistics in modern software, it is the first book on CMC statistics written primarily for practitioners. While statisticians will also benefit from this book, it is written particularly for industry professionals who don't have access to a CMC statistician or who want to be more independent in the design and analysis of their experiments. Provides an introduction to the statistical concepts important in the biotechnology industry Focuses on concepts with theoretical details kept to a minimum Includes lots of real examples and case studies to illustrate the methods Uses JMP software for implementation of the methods Offers a text suitable for scientists in the industry with some quantitative training Written and edited by seasoned veterans of the biotechnology industry, this book will prove useful to a wide variety of biotechnology professionals. The book brings together individual chapters that showcase the use of statistics in the most salient areas of CMC.

* follows the counseling principle of meeting the client where they are and questions what happens when eating disorder professionals fail to acknowledge veganism as an authentic part of their client's recovery * explores the existing research in conjunction with the ideas perpetuated around veganism and recovery, the potential harm to vegans prohibited from following veganism in treatment centers, and indications of further shifts toward normalizing veganism in the eating disorder field * discusses how to positively impact a vegan's access to treatment, the quality of their treatment, and a professional's capacity to provide optimal treatment to vegans and non-vegans alike

Luminescent materials with advanced performance are in the research hot spot with the recent technical developments of the display, lighting, and fluorescence labeling. Rare-earth-doped luminescent materials have been the focus of the research community owing to their wide applications in display devices, temperature sensors, solar cells, biomedical fields, optoelectronics, etc. This book covers the broad aspects of organic and inorganic materials based phosphors. The purpose of this book is to provide an up-to-date account of the present status and advancement of various techniques of synthesis of luminescent materials and their advanced applications in different areas. This book will cover all the experimental and theoretical approaches related to the rare-earth-doped luminescent materials. It also contains all the necessary information about the rare-earth-doped luminescent materials that were used in the past few years. In a nutshell, this book provides a unique platform to the newcomers who are planning to do research on rare-earthdoped luminescent materials as well as the researchers who are well established in this field.

Now fully updated for its fourth edition, Pharmacy: What It Is and How It Works continues to provide a comprehensive review of all aspects of pharmacy, from the various roles, pathways and settings of pharmacists to information about how pharmacy works within the broader health care system. Beginning with a brief historical perspective on the field, the book discusses the many facets of the pharmacy profession. It describes the role of pharmacists in different settings and provides information ranging from licensing requirements to working conditions, highlighting the critical role of pharmacists within the health care system. The author examines the drug use process with sections on distribution, prescribing, dispensing, and pricing. He also discusses the role of pharmacy support personnel. A chapter on informatics explores how pharmacy has evolved through information technology and automation. Additional chapters cover poison control, pharmaceutical care, pharmacy organizations, the drug approval process, and career development. Designed for classroom and professional use, the book contains numerous tools to facilitate comprehension, including: Learning objectives to help readers focus on the goals of each chapter Informative tables and figures summarizing data Summary paragraphs tying in salient points Discussion questions and exercises to test assimilation "Challenges" which place the material in broader context Websites and references to encourage further study This valuable text provides a look into the profession that is both broad and deep, supplying a one-stop introduction to a promising career in pharmacy.

How do scientists, scholars, and other experts engage with the general public and with the communities affected by their work or residing in their sites of study? Where are the fine lines between public scholarship, civic engagement, and activism? Must academics 'give back' once they collect data and publish results? In this volume, authors from a wide range of disciplines examine these relationships to assess how they can be fruitful or challenging. Describing the methodological and ethical issues that experts must consider when carrying out public scholarship, this book includes a checklist for critical factors of success in engagement and an examination of the role of digital social media in science communication. Illustrated by a range of case studies addressing environmental issues (climate change, resource use, post-disaster policy) and education, it offers an investigation into the levels and ways in which scholars can engage, and how and whether academics and experts who engage in community work and public scholarship are acknowledged and rewarded for doing so by their institutions. Also bringing into the debate the perspective of citizens who have collaborated with academics, the book offers an exploration of the democratizing potential of participatory action research.

This book explains the correct logical approach to analysis of forensic scientific evidence. The focus is on general methods of analysis applicable to all forms of evidence. It starts by explaining the general principles and then applies them to issues in DNA and other important forms of scientific evidence as examples. Like the first edition, the book analyses real legal cases and judgments rather than hypothetical examples and shows how the problems perceived in those cases would have been solved by a correct logical approach. The book is written to be understood both by forensic scientists preparing their evidence and by lawyers and judges who have to deal with it. The analysis is tied back both to basic scientific principles and to the principles of the law of evidence. This book will also be essential reading for law students taking evidence or forensic science papers and science students studying the application of their scientific specialisation to forensic questions.

Likelihood Methods in Biology and Ecology: A Modern Approach to Statistics emphasizes the importance of the likelihood function in statistical theory and applications and discusses it in the context of biology and ecology. Bayesian and frequentist methods both use the likelihood function and provide differing but related insights. This is examined here both through review of basic methodology and also the integrated use of these approaches in case studies. Features: Discusses the likelihood function in both Bayesian and frequentist contexts. Reviews and discusses standard methods of data analysis, model selection and statistical analysis, and how to apply and interpret them in real world situations. Examines the application of statistical methods to observed data in the context of case studies drawn from biology and ecology. Uniquely discusses frequentist and Bayesian approaches to statistics as complementary allowing many standard approaches to be presented in a single book. Poses questions to ask when planning the design and analysis of a study or experiment. This book is written for applied researchers, scientists, consultants, statisticians and applied scientists. Although it uses examples drawn from biology, the methods here can be applied to a wide variety of research areas and provides an accessible handbook of available statistical methods for scientific settings where there is an assumed theoretical model that can be represented using a likelihood function.

Following its bestselling predecessor, Dimensions of Food, Eighth Edition, provides beneficial classroom and independent, instructive material for students. Instructors will find that this textbook's organization makes it easy to use and very flexible for teaching. A variety of stimulating experiences allow the student to explore and comprehend the numerous dimensions of food. Part I of this lab manual contains an analysis of economic, nutritional, palatability, chemical, sanitary, and food processing dimensions of food. Part II allows students to analyze the structural and functional properties of foods such as starches, fruits and vegetables, eggs, dairy, meat, poultry and fish, fats and oils, sweeteners, and baked goods. Part III features information on microwave cooking, and Part IV concludes with beneficial ideas on meal planning. All chapters in this informative and interactive insight into food science contain learning objectives, exercises, recipes, summary questions, and updated Dietitian's Notes. Contains several helpful Appendices on topics including: Food Guides and Dietary Guidelines, Food Equivalents, Portions, Food Allergens, Food Additives, Legislation, Foodborne Illness, Cooking Terms, Herbs and Spices, and Plant Proteins.

Psoriasis is a life-long chronic autoimmune disease characterized by thick scaly skin lesions and often associated with severe arthritis. In psoriasis, lesions skin cells, keratinocytes, grow too quickly, resulting in thick, white, silvery or red patches on skin. Normal skin cells grow gradually and flake off about every four weeks, but psoriasis causes new skin cells to move rapidly to the surface of the skin in days rather than weeks. Psoriasis symptoms often appear on the elbows, scalp, feet, knees, hands, or lower back, or as flaking or patches on the skin. It is most common in adults, but teenagers and children can also suffer from psoriasis. Psoriasis is not only a skin condition; it is a chronic disease of the immune system. Chronic psoriasis is associated with other health conditions such as psoriatic arthritis, several inflammatory disorders, type 2 diabetes, and cardiovascular disease. This book provides extensive coverage of psoriasis and psoriatic arthritis. It features information on epidemiology and etiology of psoriasis, pathogenesis, genetics of psoriasis, clinical manifestations, and treatment options using cutting-edge drugs including adalimumab and tofacitinib. Natural phytochemicals and nutraceuticals have demonstrated efficacy in ameliorating psoriasis. The book dedicates comprehensive coverage of nutraceutical therapeutic options including antioxidants, bioactive peptides, carotenoids, alpha lipoic acid, curcumin, and whey protein. These inexpensive natural therapeutics are not associated with any known adverse side effects.

This comprehensive text focuses on reasoning, critical thinking and pragmatic decision making in medicine. Based on the author's extensive experience and filled with definitions, formulae, flowcharts and checklists, this fully revised second edition continues to provide invaluable guidance to the crucial role that clinical epidemiology plays in the expanding field of evidence-based medicine. Key Features: * Considers evidence-based medicine as a universal initiative common to all health sciences and professions, and all specialties within those disciplines * Demonstrates how effective practice is reliant on proper foundations, such as clinical and fundamental epidemiology, and biostatistics * Introduces the reader to basic epidemiological methods, meta-analysis and decision analysis * Shows that structured, modern, argumentative reasoning is required to build the best possible evidence and use it in practice and research * Outlines how to make the most appropriate decisions in clinical care, disease prevention and health promotion Presenting a range of topics seldom seen in a single resource, the innovative blend of informal logic and structured evidence-based reasoning makes this book invaluable for anyone seeking broad, in-depth and readable coverage of this complex and sometimes controversial field.

Presents a provocative look at various syndromes familiar to forensic psychologists, as applied to criminal cases and the pathology of suicide and homicide victims Provides information previously available only in the Spanish-language edition Combines the work of world-renowned experts to look at the criminal, legal, and psychological facets of various diagnoses and case examples Offers insight into the psychological state of suicide victims, considering their state of mind as a "psychological autopsy"

Praise for the third edition of Bioinformatics "This book is a gem to read and use in practice." --Briefings in Bioinformatics "This volume has a distinctive, special value as it offers an unrivalled level of details and unique expert insights from the leading computational biologists, including the very creators of popular bioinformatics tools." --ChemBioChem "A valuable survey of this fascinating field. . . I found it to be the most useful book on bioinformatics that I have seen and recommend it very highly." --American Society for Microbiology News "This should be on the bookshelf of every molecular biologist." --The Quarterly Review of Biolog" The field of bioinformatics is advancing at a remarkable rate. With the development of new analytical techniques that make use of the latest advances in machine learning and data science, today's biologists are gaining fantastic new insights into the natural world's most complex systems. These rapidly progressing innovations can, however, be difficult to keep pace with. The expanded fourth edition of the best-selling Bioinformatics aims to remedy this by providing students and professionals alike with a comprehensive survey of the current field. Revised to reflect recent advances in computational biology, it offers practical instruction on the gathering, analysis, and interpretation of data, as well as explanations of the most powerful algorithms presently used for biological discovery. Bioinformatics, Fourth Edition offers the most readable, up-to-date, and thorough introduction to the field for biologists at all levels, covering both key concepts that have stood the test of time and the new and important developments driving this fast-moving discipline forwards. This new edition features: New chapters on metabolomics, population genetics, metagenomics and microbial community analysis, and translational bioinformatics A thorough treatment of statistical methods as applied to biological data Special topic boxes and appendices highlighting experimental strategies and advanced concepts Annotated reference lists, comprehensive lists of relevant web resources, and an extensive glossary of commonly used terms in bioinformatics, genomics, and proteomics Bioinformatics is an indispensable companion for researchers, instructors, and students of all levels in molecular biology and computational biology, as well as investigators involved in genomics, clinical research, proteomics, and related fields.

Practicing statisticians and scientists working in diverse fields need an authoritative reference handbook of statistical tables developed to "aid" in the investigation and solution of many of today's challenging problems. This book has been compiled and arranged to meet the needs of these users of statistics.

Assistive Technology Assessment Handbook, Second Edition, proposes an international ideal model for the assistive technology assessment process, outlining how this model can be applied in practice to re-conceptualize the phases of an assistive technology delivery system according to the biopsychosocial model of disability. The model provides reference guidelines for evidence-based practice, guiding both public and private centers that wish to compare, evaluate, and improve their ability to match a person with the correct technology model. This second edition also offers a contribution to the Global Cooperation on Assistive Technology (GATE) initiative, whose activities are strongly focused on the assistive products service delivery model. Organized into three parts, the handbook: gives readers a toolkit for performing assessments; describes the roles of the assessment team members, among them the new profession of psychotechnologist; and reviews technologies for rehabilitation and independent living, including brain-computer interfaces, exoskeletons, and technologies for music therapy. Edited by Stefano Federici and Marcia J. Scherer, this cross-cultural handbook includes contributions from leading experts across five continents, offering a framework for future practice and research.

A short but engaging exploration of the brain. In Brains, scientist Leif Østergaard explores our most complicated and mysterious organ. From the dissection of Einstein's brain to research on how to map networks of neurons, Østergaard deconstructs the different parts of the brain and provides an engaging overview of its essential functions. He explains how we store information in the synapses of neural networks and how these networks carry commands to our muscles and internal organs and receive sensory input from our skin, eyes, ears, nose, and mouth. Delving into the subconscious, we learn what our brains are doing while we daydream and how neurotransmitters play a role in addiction. In this fascinating book, Østergaard reveals how this enigmatic organ is even more complex than we thought it was. In Reflections, a series copublished with Denmark's Aarhus University Press, scholars deliver 60-page reflections on key concepts. These books present unique insights on a wide range of topics that entertain and enlighten readers with exciting discoveries and new perspectives.

Quality refers to the amount of the unpriced attributes contained in each unit of the priced attribute. Leffler, 1982 Quality is neither mind nor matter, but a third entity independent of the two, even though Quality cannot be defined, you know what it is. Pirsig, 2000 The continuous formulation of good practices and procedures across fields reflects the importance of the recognition and maintenance of "quality" for nearly every profession. The widespread introduction of point-of-care testing, centralization of activities in large core laboratories, and the increase in number and complexity of diagnostic testing worldwide has driven changes in the organization of laboratory diagnostics over the past decades. As such, laboratory diagnostics, continuously catching up to updated techniques and complex procedures, need to stay vigilant about safety and good practices adjustments. Although widely defined and quantified, the concept of quality is an intrinsic feature of the human psyche and decision making. Written to improve laboratory work, Quality Assurance in the Pathology Laboratory examines: Quality assurance of quantifiable methods applied in laboratory medicine and toxicology Quality aspects of emerging disciplines including personalized therapy and virtopsy Regulatory and logistic instrumentation that ensure quality in laboratory methods Professional education at the graduate and postgraduate levels Laboratory diagnostics substantially contributes to clinical decision making by providing valuable information for the screening, diagnosis, therapeutic monitoring, and follow-up of most-if not all-human disorders. Providing general insights into the quality assurance aspects of pathology and laboratory medicine, this book aids in improving laboratory work and, at the same time, shows the possibilities and limits of all logistic and legal tools related to quality issues.

It is the purpose of this book to try to offer a modern perspective on the importance of vitamins in human biology and medicine. There have been recent revivals of attempts to use vitamins as therapeutic agents by administering doses many times the recommended allowance. This use or 'megavitamin therapy' is reviewed by Dr. Reynold Spector, with particular emphasis on vitamin entry to the central nervous system. Of related interest is the chapter by Dr. John Blass discussing central nervous system manifestations of thiamin deficiency, and also the contribution by Ms. Fiona Cumming and clinical toxicity of vitamin supplementation.

An in-depth overview of the emerging concept; Mobile Health (mHealth), mHealth Multidisciplinary Verticals links applications and technologies to key market and vendor players. It also highlights interdependencies and synergies between various stakeholders which drive the research forces behind mHealth. The book explores the trends and directions where this vertical market is headed. Divided into nine sections, the book covers a number of multidisciplinary verticals within the field of mHealth such as: Preventive and curative medicine Consumer and patient-centric approaches Psychological, behavioral, and mental verticals Social perspectives Education, adoption, and acceptance Aged care and the aging population Regional, geographical, and public-health perspectives Technology implications Cloud applications The book collates emerging and diverse mHealth applications into a single resource. The result of extensive research, the book is a collaborative effort between experts from more than 20 countries, who have been carefully reviewed and selected by the team of reviewers. It takes a multidisciplinary approach to health informatics and provides a roadmap to current and future directions of mHealth.

In Fundamentals of Forensic Photography, Keith Mancini and John Sidoriak offer practical techniques for common situations encountered in forensic documentation. Topics include equipment selection, lighting techniques, crime scene and evidence documentation, macro and micro photography as well as aerial, high speed and computational photography. Techniques for photographic documentation in both the laboratory and the field are discussed.

Nanomedicine for Inflammatory Diseases is a cutting-edge resource for clinicians and scientists alike, working at the intersection of development and clinical therapeutics. This text is ideal for graduate level courses in nanomedicine, translational medicine, or inflammatory disease. This book is a progressive hallmark in translational medicine as it unites clinicians treating inflammatory disease with scientists developing experimental nanomedicine therapeutics. The commonality is made through a translational nanomedicine expert - bridging the gap between the laboratory benchtop and the clinical bedside.

First published in 1980. Animal agriculture serves human needs. Three-fourths of the protein, one-third of the energy, most of the calcium and phosphorus and substantial amounts of essential vitamins and other minerals in the American diet are from animal products. Recognizing that innovative research holds the key to meeting these challenges, 210 concerned individuals convened at Boyne Mountain, Michigan, May 4 to 9, 1980. Their goal was to identify priorities for future research to enable animal agriculture to efficiently and effectively serve human needs in the 21st century. These proceedings represent the best collective judgment on research priorities by a group of informed and dedicated people concerned with the future role of animal agriculture in meeting human needs.

Hunger and Poverty in South Africa: The Hidden Faces of Food Insecurity explores food insecurity as an issue of socioeconomic, political, cultural and environmental inequity and inequality. Based on extensive original research in Free State Province, South Africa, the book explores how people living in poverty make meaning of their food circumstances within the socio-cultural, political and economic contexts of post-apartheid South Africa, how they view the government's food security policies and programs and their perceived agency to affect change. The personal narratives contained in the book show that food insecurity is shaped by many issues, among which are structural poverty, racism, attempts or non-attempts at reconciliation during and after apartheid, public health issues such as HIV/AIDS, and environmental circumstances. At a time when most discourse around food insecurity focuses on how to provide more food to people facing hunger, this book's multidimensional approach is a valuable contribution to the contemporary dialogue on poverty, food security/insecurity, sustainability and democratic agency both within South Africa and around the world. This book will be of interest to researchers in the areas of food security, multidimensional poverty, democratic agency and sustainable development, both in South Africa and internationally.

A fully updated textbook helping advanced students and young scientists navigate the ethical challenges that are common to scientific researchers in academia As the number of scientific journals, government regulations, and institutional guidelines continue to grow, research scientists are increasingly facing ethical dilemmas. Even seasoned and honest scientists can unintentionally commit research misconduct or fail to detect and address intentional misbehavior. Research Ethics for Scientists is an authoritative “how-to� guide that clearly outlines best practices in scientific research. Critically examining the key problems that arise in research management and practice, this real-world handbook helps students and young scientists conduct scientific research that adheres to the highest ethical standards. Accessible chapters, logically organized into functional themes and units, cover all the major areas that are crucial for sustained success in science: ideas, people, data, publications, and funding. The second edition offers new and updated content throughout, including discussions of recent innovations to detect and adjudicate research misconduct, vulnerabilities in research practices that were exposed by the COVID-19 pandemic, and new methods people are using to cheat the system and skew the peer review process. Entirely new case studies focus on harassment and bullying in training and mentorship, anti-science and pseudoscience, equality and equity issues, the fabrication of data, and more. This edition integrates gender, race, student training, and other important social issues throughout. Presents up-to-date coverage of growing issues such as the ethics of rushing to publish Discusses the use of text-similarity detecting software to reveal plagiarism and image analysis techniques for detecting data and image manipulation Features new material on current trends such as universal open access (OA) publishing, increased research metrics, new models for peer review, working for multiple employers, and “shadow labs� for individual scientists Includes access to a companion website with PowerPoint slides of case studies and figures Written by an experienced researcher and PhD mentor, Research Ethics for Scientists: A Companion for Students, Second Edition is an indispensable resource for graduate students, postdoctoral researchers, early-career professors, and scientists involved in teaching scientists-in-training.