Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants. Systems Biology in Toxicology and Environmental Health is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health.

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales - including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces - bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

The second volume in a series which aims to focus on advances in computational biology. This volume discusses such topics as: statistical analysis of protein sequences; progress in large-scale sequence analysis; and the architecture of loops in proteins.

The technologies in data mining have been applied to bioinformatics research in the past few years with success, but more research in this field is necessary. While tremendous progress has been made over the years, many of the fundamental challenges in bioinformatics are still open. Data mining plays a essential role in understanding the emerging problems in genomics, proteomics, and systems biology. ""Advanced Data Mining Technologies in Bioinformatics"" covers important research topics of data mining on bioinformatics. Readers of this book will gain an understanding of the basics and problems of bioinformatics, as well as the applications of data mining technologies in tackling the problems and the essential research topics in the field. ""Advanced Data Mining Technologies in Bioinformatics"" is extremely useful for data mining researchers, molecular biologists, graduate students, and others interested in this topic.

BODILY CHANGES IN PAIN, HUNGER, FEAR AND RAGE- AN ACCOUNT OF RECENT RE SEARCHES INTO THE FUNCTION OF EMOTIONAL EXCITEMENT by WALTER B. CANNON. Originally published in 1927. PREFACE: Fear, rage and pain, and the pangs of hunger are all primitive experiences which human beings share with the lower animals. These experiences are properly classed as among the most powerful that determine the action of men and beasts. A knowledge of the conditions which attend these experiences, therefore, is of general and fundamental importance in the interpretation of behavior. During the past four years there has been conducted, in the Harvard Physiological Laboratory, a series of in vestigations concerned with the bodily changes which occur in conjunction with pain, hunger and the major emotions. A group of remarkable alterations in the bodily economy have been discovered, all of which can reasonably be regarded as responses that are nicely adapted to the individual's welfare and preservation. Because these physiological adaptations are interesting both in themselves and in their interpretation, not only to physiologists and psychologists, but to others as well, it has seemed worth while to gather together in con venient form the original accounts of the experiments, which have been published in various American medical and physiological journals. I have, however, attempted to arrange the results and discussions in an orderly and consecutive manner, and I have tried also to eliminate or incidentally to explain the technical terms, so that the exposition will be easily understood by any intelligent reader even though not trained in the med ical sciences. My first interest in the conditions attendingpain, hunger and strong emotional states was stimulated dur ing the course of a previous series of researches on the motor activities of the alimentary canal. A summary of these researches appeared in 1911, under the title, The Mechanical Factors of Digestion. The studies recorded in the present volume may be regarded as a natural sequence of observations on the influence of emotional states on the digestive process, which were reported in that volume. W. B. CANNON. Contents include: CHAPTER I: PAGES THE EFFECT OF THE EMOTIONS ON DIGESTION 1-21. CHAPTER II: THE GENERAL ORGANIZATION 40-51. CHAPTER IV ADRENAL SECRETION IN STRONG EMOTIONS AND PAIN 52-65. CHAPTER V THE INCREASE OF BLOOD SUGAR IN PAIN AND GREAT EMOTION ...

This book (hardcover) is part of the TREDITION CLASSICS. It contains classical literature works from over two thousand years. Most of these titles have been out of print and off the bookstore shelves for decades. The book series is intended to preserve the cultural legacy and to promote the timeless works of classical literature. Readers of a TREDITION CLASSICS book support the mission to save many of the amazing works of world literature from oblivion. With this series, tredition intends to make thousands of international literature classics available in printed format again - worldwide.

Synthetic biology is a new area of biological research that combines science and engineering in order to design and build novel biological functions and systems. The definition of synthetic biology has been generally accepted as the engineering of biology: the synthesis of complex, biologically based (or inspired) systems, which display functions that do not exist in nature. This engineering perspective may be applied at all levels of the hierarchy of biological structures from individual molecules to whole cells, tissues and organisms. As with any multi-disciplinary field, there is an immense and rapidly-growing body of literature concerning synthetic biology, with several dedicated journals now available. However, locating the best information, or identifying the hottest topics can be time-consuming. This Specialist Periodical Report presents critical and comprehensive reviews of the recent literature in themed chapters prepared by invited authors from across the globe. The series editors are active in the field, ensuring that the most valuable information is presented in an authoritative manner.

Why is life the way it is? Bacteria evolved into complex life just once in four billion years of life on earth-and all complex life shares many strange properties, from sex to ageing and death. If life evolved on other planets, would it be the same or completely different? In The Vital Question, Nick Lane radically reframes evolutionary history, putting forward a cogent solution to conundrums that have troubled scientists for decades. The answer, he argues, lies in energy: how all life on Earth lives off a voltage with the strength of a bolt of lightning. In unravelling these scientific enigmas, making sense of life's quirks, Lane's explanation provides a solution to life's vital questions: why are we as we are, and why are we here at all? This is ground-breaking science in an accessible form, in the tradition of Charles Darwin's The Origin of Species, Richard Dawkins' The Selfish Gene, and Jared Diamond's Guns, Germs and Steel.

The value of multi-disciplinary research lies in the exchange of ideas and methods across the traditional boundaries between areas of study. It could be argued that many of the advances in science and engineering take place because the ideas, methods and the tools of thought from one discipline become re-applied in another.
The topic of "the visual" has become increasingly important as advances in technology have led to multi-media and multi-modal representations, and extended the range and scope of visual representation and interpretation in our lives. Under this broad heading there are many different perspectives and approaches, from across the entire spectrum of human knolwedge and activity.
The editors and authors of this book aim to break down cross-disciplinary barriers, by bringing together people working in a wide variety of disciplines where visual representations and interpretations are exploited. Contributions come from researchers actively investigating visual representations and interpretations in a wide variety of areas, including art history, biology, clinical science, cognitive science, computer science, design, engineering, linguistics, mathematics, philosophy, physics, psychology, and sociology.
The book provides a forum for wide-ranging and multi-disciplinary contributions on visual representations and interpretations.
* Contributors include researchers actively investigating visual representations and interpretations
* Content spans a wide variety of areas including but not limited to biology, sociology, and computer science
* Discusses how new technology has affected "the visual" representation of information