Written specifically for biotechnology scientists, engineers, and quality professionals, this book describes and demonstrates the proper application of statistical methods throughout Chemistry, Manufacturing, and Controls (CMC). Filled with case studies, examples, and easy-to-follow explanations of how to perform statistics in modern software, it is the first book on CMC statistics written primarily for practitioners. While statisticians will also benefit from this book, it is written particularly for industry professionals who don't have access to a CMC statistician or who want to be more independent in the design and analysis of their experiments. Provides an introduction to the statistical concepts important in the biotechnology industry Focuses on concepts with theoretical details kept to a minimum Includes lots of real examples and case studies to illustrate the methods Uses JMP software for implementation of the methods Offers a text suitable for scientists in the industry with some quantitative training Written and edited by seasoned veterans of the biotechnology industry, this book will prove useful to a wide variety of biotechnology professionals. The book brings together individual chapters that showcase the use of statistics in the most salient areas of CMC.

This book explains the correct logical approach to analysis of forensic scientific evidence. The focus is on general methods of analysis applicable to all forms of evidence. It starts by explaining the general principles and then applies them to issues in DNA and other important forms of scientific evidence as examples. Like the first edition, the book analyses real legal cases and judgments rather than hypothetical examples and shows how the problems perceived in those cases would have been solved by a correct logical approach. The book is written to be understood both by forensic scientists preparing their evidence and by lawyers and judges who have to deal with it. The analysis is tied back both to basic scientific principles and to the principles of the law of evidence. This book will also be essential reading for law students taking evidence or forensic science papers and science students studying the application of their scientific specialisation to forensic questions.

Likelihood Methods in Biology and Ecology: A Modern Approach to Statistics emphasizes the importance of the likelihood function in statistical theory and applications and discusses it in the context of biology and ecology. Bayesian and frequentist methods both use the likelihood function and provide differing but related insights. This is examined here both through review of basic methodology and also the integrated use of these approaches in case studies. Features: Discusses the likelihood function in both Bayesian and frequentist contexts. Reviews and discusses standard methods of data analysis, model selection and statistical analysis, and how to apply and interpret them in real world situations. Examines the application of statistical methods to observed data in the context of case studies drawn from biology and ecology. Uniquely discusses frequentist and Bayesian approaches to statistics as complementary allowing many standard approaches to be presented in a single book. Poses questions to ask when planning the design and analysis of a study or experiment. This book is written for applied researchers, scientists, consultants, statisticians and applied scientists. Although it uses examples drawn from biology, the methods here can be applied to a wide variety of research areas and provides an accessible handbook of available statistical methods for scientific settings where there is an assumed theoretical model that can be represented using a likelihood function.

The ultimate guide to understanding the biology and behavior of the amazing and underappreciated American alligator. Few scenes put the senses on edge more than a submerged alligator, only eyes and snout showing, when peering across a southern lake on a misty morning. An iconic American predator, these reptiles grow to thirteen feet or more and can live as long as humans. Alligators are complex creatures, capable of terrific attacks and yet tending to their young in the same gentle way a mother duck looks after her brood. Once extremely numerous, alligators came close to extinction in the twentieth century, but thanks to conservation efforts have since made a comeback, reclaiming their rightful place as the monarchs of the southern wetlands. In this fascinating account, richly illustrated with more than 150 photographs from award-winning wildlife photographer Wayne Lynch, expert zoologist Kent A. Vliet introduces readers to the biology, ecology, and natural history of the American alligator. Sharing nuanced depictions of their hidden lives that will forever change the way you think of these giant reptiles, the book * combines captivating storytelling with the most current scientific facts * chronicles the life cycle of the alligator * explains why the alligator's precise anatomy and physiology make it so successful * covers a wide range of topics, from courtship and reproduction to communication, basking, nest-building, and hunting * reveals the alligator's sophisticated social life in detail * evaluates the alligator's environmental role as a keystone species * examines the complicated relationship between alligators and people

Since 1994, Molecular Biotechnology: Principles and Applications of Recombinant DNA has introduced students to the fast-changing world of molecular biotechnology. With each revision, the authors have extensively updated the book to keep pace with the many new techniques in gene isolation and amplification, nucleic acid synthesis and sequencing, gene editing, and their applications to biotechnology. In this edition, authors Bernard R. Glick and Cheryl L. Patten have continued that tradition, but have also overhauled the book's organization to Detail fundamental molecular biology methods and recombinant protein engineering techniques, which provides students with a solid scientific basis for the rest of the book. Present the processes of molecular biotechnology and its successes in medicine, bioremediation, raw material production, biofuels, and agriculture. Examine the intersection of molecular biotechnology and society, including regulation, patents, and controversies around genetically modified products. Filled with engaging figures that strongly support the explanations in the text, Molecular Biotechnology: Principles and Applications of Recombinant DNA presents difficult scientific concepts and technically challenging methods in clear, crisp prose. This excellent textbook is ideal for undergraduate and graduate courses in introductory biotechnology, as well as, courses dedicated to medical, agricultural, environmental, and industrial biotechnology applications.

Most medical treatments have been designed for the "average patient." As a result of this "one-size-fits-all-approach," treatments can be very successful for some patients but not for others. This is changing with the emergence of precision medicine, an innovative approach to disease prevention and treatment that takes into account individual differences in people's genes, environments, and lifestyles. Precision medicine gives clinicians tools to better understand the complex mechanisms underlying a patient's health, disease, or condition, and to better predict which treatments will be most effective. Precision or personalized medicine in cancer treatment was once a buzzword, but it is finally becoming a reality with recent advances in imaging, genetic, and biological sciences. The importance of interpatient and intratumor variability has long been recognized, but realistic opportunities to take these into account in cancer care have emerged only recently. Innovations in patient characterization through genomics, proteomics, and metabolomics have opened new avenues to personalize cancer treatment in ways that were not possible before. Furthermore, advances in quantitative assessment of therapeutic response, as provided by functional and molecular imaging, have been critical in the implementation of precision medicine paradigm in radiation oncology. This book will be a comprehensive review of science and technology making precision medicine possible for radiation oncology, current examples and future direction.

Now fully updated for its fourth edition, Pharmacy: What It Is and How It Works continues to provide a comprehensive review of all aspects of pharmacy, from the various roles, pathways and settings of pharmacists to information about how pharmacy works within the broader health care system. Beginning with a brief historical perspective on the field, the book discusses the many facets of the pharmacy profession. It describes the role of pharmacists in different settings and provides information ranging from licensing requirements to working conditions, highlighting the critical role of pharmacists within the health care system. The author examines the drug use process with sections on distribution, prescribing, dispensing, and pricing. He also discusses the role of pharmacy support personnel. A chapter on informatics explores how pharmacy has evolved through information technology and automation. Additional chapters cover poison control, pharmaceutical care, pharmacy organizations, the drug approval process, and career development. Designed for classroom and professional use, the book contains numerous tools to facilitate comprehension, including: Learning objectives to help readers focus on the goals of each chapter Informative tables and figures summarizing data Summary paragraphs tying in salient points Discussion questions and exercises to test assimilation "Challenges" which place the material in broader context Websites and references to encourage further study This valuable text provides a look into the profession that is both broad and deep, supplying a one-stop introduction to a promising career in pharmacy.

How do scientists, scholars, and other experts engage with the general public and with the communities affected by their work or residing in their sites of study? Where are the fine lines between public scholarship, civic engagement, and activism? Must academics 'give back' once they collect data and publish results? In this volume, authors from a wide range of disciplines examine these relationships to assess how they can be fruitful or challenging. Describing the methodological and ethical issues that experts must consider when carrying out public scholarship, this book includes a checklist for critical factors of success in engagement and an examination of the role of digital social media in science communication. Illustrated by a range of case studies addressing environmental issues (climate change, resource use, post-disaster policy) and education, it offers an investigation into the levels and ways in which scholars can engage, and how and whether academics and experts who engage in community work and public scholarship are acknowledged and rewarded for doing so by their institutions. Also bringing into the debate the perspective of citizens who have collaborated with academics, the book offers an exploration of the democratizing potential of participatory action research.

Following its bestselling predecessor, Dimensions of Food, Eighth Edition, provides beneficial classroom and independent, instructive material for students. Instructors will find that this textbook's organization makes it easy to use and very flexible for teaching. A variety of stimulating experiences allow the student to explore and comprehend the numerous dimensions of food. Part I of this lab manual contains an analysis of economic, nutritional, palatability, chemical, sanitary, and food processing dimensions of food. Part II allows students to analyze the structural and functional properties of foods such as starches, fruits and vegetables, eggs, dairy, meat, poultry and fish, fats and oils, sweeteners, and baked goods. Part III features information on microwave cooking, and Part IV concludes with beneficial ideas on meal planning. All chapters in this informative and interactive insight into food science contain learning objectives, exercises, recipes, summary questions, and updated Dietitian's Notes. Contains several helpful Appendices on topics including: Food Guides and Dietary Guidelines, Food Equivalents, Portions, Food Allergens, Food Additives, Legislation, Foodborne Illness, Cooking Terms, Herbs and Spices, and Plant Proteins.

This comprehensive text focuses on reasoning, critical thinking and pragmatic decision making in medicine. Based on the author's extensive experience and filled with definitions, formulae, flowcharts and checklists, this fully revised second edition continues to provide invaluable guidance to the crucial role that clinical epidemiology plays in the expanding field of evidence-based medicine. Key Features: * Considers evidence-based medicine as a universal initiative common to all health sciences and professions, and all specialties within those disciplines * Demonstrates how effective practice is reliant on proper foundations, such as clinical and fundamental epidemiology, and biostatistics * Introduces the reader to basic epidemiological methods, meta-analysis and decision analysis * Shows that structured, modern, argumentative reasoning is required to build the best possible evidence and use it in practice and research * Outlines how to make the most appropriate decisions in clinical care, disease prevention and health promotion Presenting a range of topics seldom seen in a single resource, the innovative blend of informal logic and structured evidence-based reasoning makes this book invaluable for anyone seeking broad, in-depth and readable coverage of this complex and sometimes controversial field.

Presents a provocative look at various syndromes familiar to forensic psychologists, as applied to criminal cases and the pathology of suicide and homicide victims Provides information previously available only in the Spanish-language edition Combines the work of world-renowned experts to look at the criminal, legal, and psychological facets of various diagnoses and case examples Offers insight into the psychological state of suicide victims, considering their state of mind as a "psychological autopsy"

Practicing statisticians and scientists working in diverse fields need an authoritative reference handbook of statistical tables developed to "aid" in the investigation and solution of many of today's challenging problems. This book has been compiled and arranged to meet the needs of these users of statistics.

Provocative, ground-breaking and entertaining, the world’s leading expert on sexuality and the ovulation cycle reveals the hidden intelligence of hormones.

Did you know that at certain times of the month, women are inclined to dance more? Flirt more? Or that PMS may have evolved to remove boyfriends with unfit sperm? Why? Hormones.

Hormones help women choose mates, produce healthy offspring, raise them successfully, and, ultimately, make better decisions.

In this paradigm-shifting book, Martie Haselton explains how hormonal intelligence works – both its strengths and its weaknesses – and how women can track and understand their desires, fears and perceptions. By exploring the biological processes that profoundly influence our behaviour, Hormonal sets forth a radical, new understanding of women's bodies, one that sees hormonal cycles as adaptive solutions to genuine biological challenges.

This book will empower women everywhere to embrace their biology.

Psoriasis is a life-long chronic autoimmune disease characterized by thick scaly skin lesions and often associated with severe arthritis. In psoriasis, lesions skin cells, keratinocytes, grow too quickly, resulting in thick, white, silvery or red patches on skin. Normal skin cells grow gradually and flake off about every four weeks, but psoriasis causes new skin cells to move rapidly to the surface of the skin in days rather than weeks. Psoriasis symptoms often appear on the elbows, scalp, feet, knees, hands, or lower back, or as flaking or patches on the skin. It is most common in adults, but teenagers and children can also suffer from psoriasis. Psoriasis is not only a skin condition; it is a chronic disease of the immune system. Chronic psoriasis is associated with other health conditions such as psoriatic arthritis, several inflammatory disorders, type 2 diabetes, and cardiovascular disease. This book provides extensive coverage of psoriasis and psoriatic arthritis. It features information on epidemiology and etiology of psoriasis, pathogenesis, genetics of psoriasis, clinical manifestations, and treatment options using cutting-edge drugs including adalimumab and tofacitinib. Natural phytochemicals and nutraceuticals have demonstrated efficacy in ameliorating psoriasis. The book dedicates comprehensive coverage of nutraceutical therapeutic options including antioxidants, bioactive peptides, carotenoids, alpha lipoic acid, curcumin, and whey protein. These inexpensive natural therapeutics are not associated with any known adverse side effects.

Assistive Technology Assessment Handbook, Second Edition, proposes an international ideal model for the assistive technology assessment process, outlining how this model can be applied in practice to re-conceptualize the phases of an assistive technology delivery system according to the biopsychosocial model of disability. The model provides reference guidelines for evidence-based practice, guiding both public and private centers that wish to compare, evaluate, and improve their ability to match a person with the correct technology model. This second edition also offers a contribution to the Global Cooperation on Assistive Technology (GATE) initiative, whose activities are strongly focused on the assistive products service delivery model. Organized into three parts, the handbook: gives readers a toolkit for performing assessments; describes the roles of the assessment team members, among them the new profession of psychotechnologist; and reviews technologies for rehabilitation and independent living, including brain-computer interfaces, exoskeletons, and technologies for music therapy. Edited by Stefano Federici and Marcia J. Scherer, this cross-cultural handbook includes contributions from leading experts across five continents, offering a framework for future practice and research.

It is the purpose of this book to try to offer a modern perspective on the importance of vitamins in human biology and medicine. There have been recent revivals of attempts to use vitamins as therapeutic agents by administering doses many times the recommended allowance. This use or 'megavitamin therapy' is reviewed by Dr. Reynold Spector, with particular emphasis on vitamin entry to the central nervous system. Of related interest is the chapter by Dr. John Blass discussing central nervous system manifestations of thiamin deficiency, and also the contribution by Ms. Fiona Cumming and clinical toxicity of vitamin supplementation.

An in-depth overview of the emerging concept; Mobile Health (mHealth), mHealth Multidisciplinary Verticals links applications and technologies to key market and vendor players. It also highlights interdependencies and synergies between various stakeholders which drive the research forces behind mHealth. The book explores the trends and directions where this vertical market is headed. Divided into nine sections, the book covers a number of multidisciplinary verticals within the field of mHealth such as: Preventive and curative medicine Consumer and patient-centric approaches Psychological, behavioral, and mental verticals Social perspectives Education, adoption, and acceptance Aged care and the aging population Regional, geographical, and public-health perspectives Technology implications Cloud applications The book collates emerging and diverse mHealth applications into a single resource. The result of extensive research, the book is a collaborative effort between experts from more than 20 countries, who have been carefully reviewed and selected by the team of reviewers. It takes a multidisciplinary approach to health informatics and provides a roadmap to current and future directions of mHealth.

In Fundamentals of Forensic Photography, Keith Mancini and John Sidoriak offer practical techniques for common situations encountered in forensic documentation. Topics include equipment selection, lighting techniques, crime scene and evidence documentation, macro and micro photography as well as aerial, high speed and computational photography. Techniques for photographic documentation in both the laboratory and the field are discussed.

First published in 1980. Animal agriculture serves human needs. Three-fourths of the protein, one-third of the energy, most of the calcium and phosphorus and substantial amounts of essential vitamins and other minerals in the American diet are from animal products. Recognizing that innovative research holds the key to meeting these challenges, 210 concerned individuals convened at Boyne Mountain, Michigan, May 4 to 9, 1980. Their goal was to identify priorities for future research to enable animal agriculture to efficiently and effectively serve human needs in the 21st century. These proceedings represent the best collective judgment on research priorities by a group of informed and dedicated people concerned with the future role of animal agriculture in meeting human needs.

This best-selling title both in German and English is now enhanced by a new chapter on the important topical subject of measurement uncertainty, plus a CD-ROM with interactive examples in the form of Excel-spreadsheets. These allow readers to gain an even better comprehension of the statistical procedures for quality assurance while also incorporating their own data.

Following an introduction, the text goes on to elucidate the 4-phase model of analytical quality assurance: establishing a new analytical process, preparative quality assurance, routine quality assurance and external analytical quality assurance.

Besides updating the relevant references, the authors took great care to incorporate the latest international standards in the field.

Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

A fully updated textbook helping advanced students and young scientists navigate the ethical challenges that are common to scientific researchers in academia As the number of scientific journals, government regulations, and institutional guidelines continue to grow, research scientists are increasingly facing ethical dilemmas. Even seasoned and honest scientists can unintentionally commit research misconduct or fail to detect and address intentional misbehavior. Research Ethics for Scientists is an authoritative “how-to” guide that clearly outlines best practices in scientific research. Critically examining the key problems that arise in research management and practice, this real-world handbook helps students and young scientists conduct scientific research that adheres to the highest ethical standards. Accessible chapters, logically organized into functional themes and units, cover all the major areas that are crucial for sustained success in science: ideas, people, data, publications, and funding. The second edition offers new and updated content throughout, including discussions of recent innovations to detect and adjudicate research misconduct, vulnerabilities in research practices that were exposed by the COVID-19 pandemic, and new methods people are using to cheat the system and skew the peer review process. Entirely new case studies focus on harassment and bullying in training and mentorship, anti-science and pseudoscience, equality and equity issues, the fabrication of data, and more. This edition integrates gender, race, student training, and other important social issues throughout. Presents up-to-date coverage of growing issues such as the ethics of rushing to publish Discusses the use of text-similarity detecting software to reveal plagiarism and image analysis techniques for detecting data and image manipulation Features new material on current trends such as universal open access (OA) publishing, increased research metrics, new models for peer review, working for multiple employers, and “shadow labs” for individual scientists Includes access to a companion website with PowerPoint slides of case studies and figures Written by an experienced researcher and PhD mentor, Research Ethics for Scientists: A Companion for Students, Second Edition is an indispensable resource for graduate students, postdoctoral researchers, early-career professors, and scientists involved in teaching scientists-in-training.

What can the interactions of ancient mammals and their environments tell us about the present-and the future? Classic paleontology has focused on the study of fossils and the reconstruction of lineages of extinct species. But as diverse fossils of animals and plants were unearthed and catalogued, it became possible to reconstruct more elaborate ecosystems, tying together plants, animals, and geology. By the second half of the twentieth century, this effort gave birth to the field of paleoecology: the study of the interactions between organisms and their environments across geologic timescales. In Mammalian Paleoecology, Felisa Smith broadly considers extinct mammals in an ecological context. Arguing that the past has much to teach us and that mammals, which display an impressive array of diverse life history and ecological characteristics, are the ideal organism through which to view the fossil record, Smith * reviews the history, major fossil-hunting figures, and fundamental principles of paleoecology, including stratigraphy, dating, and taphonomy * discusses the importance of mammal body size, how to estimate size, and what size and shape reveal about long-dead organisms * explains the structure, function, and utility of different types of mammal teeth * highlights other important methods and proxies used in modern paleoecology, including stable isotopes, ancient DNA, and paleomidden analyses * assesses nontraditional fossils * presents readers with several case studies that describe how the fossil record can help inform the scientific discussion on anthropogenic climate change Mammalian Paleoecology is an approachable overview of how we obtain information from fossils and what this information can tell us about the environments of the distant past. It will profoundly affect the way paleontologists and climatologists view the lives of ancient mammals.

Handbook for Death Scene Investigators provides concise information in a handy, pocket-sized (3 1/2" x 6") format - perfect for on-the-scene reference. Details about sudden natural deaths by disease and accidents are emphasized in this guidebook, complemented with practical information on: reviewing a medical chart collecting evidence obtaining a medical history interacting with other law enforcement personnel, witnesses, and relatives Anyone responsible for investigating natural deaths - from police investigators to medical examiners - can go direct to the information they need at a moment's notice with the Handbook for Death Scene Investigators Features

Quality refers to the amount of the unpriced attributes contained in each unit of the priced attribute. Leffler, 1982 Quality is neither mind nor matter, but a third entity independent of the two, even though Quality cannot be defined, you know what it is. Pirsig, 2000 The continuous formulation of good practices and procedures across fields reflects the importance of the recognition and maintenance of "quality" for nearly every profession. The widespread introduction of point-of-care testing, centralization of activities in large core laboratories, and the increase in number and complexity of diagnostic testing worldwide has driven changes in the organization of laboratory diagnostics over the past decades. As such, laboratory diagnostics, continuously catching up to updated techniques and complex procedures, need to stay vigilant about safety and good practices adjustments. Although widely defined and quantified, the concept of quality is an intrinsic feature of the human psyche and decision making. Written to improve laboratory work, Quality Assurance in the Pathology Laboratory examines: Quality assurance of quantifiable methods applied in laboratory medicine and toxicology Quality aspects of emerging disciplines including personalized therapy and virtopsy Regulatory and logistic instrumentation that ensure quality in laboratory methods Professional education at the graduate and postgraduate levels Laboratory diagnostics substantially contributes to clinical decision making by providing valuable information for the screening, diagnosis, therapeutic monitoring, and follow-up of most-if not all-human disorders. Providing general insights into the quality assurance aspects of pathology and laboratory medicine, this book aids in improving laboratory work and, at the same time, shows the possibilities and limits of all logistic and legal tools related to quality issues.