Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales - including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces - bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

The Integrated Control of Cell Proliferation and Cell Viability; G.I. Evan, et al. Control of Invasive Cell Growth by the MET Family Oncogenes; F. Galimi, P.M. Comoglio. Src Family Kinases and the Cell Cycle; S.A. Courtneidge. p16 Family Inhibitors of Cyclin-Dependent Kinases; Y. Li, et al. p53-Mediated Apoptosis: Regulatory and Mechanistic Aspects; Y. Haupt, et al. The Molecular Genetics of Wilms Tumor; J. Pelletier, et al. HTLV-1 Tax: A Paradigm for How a Single Auxiliary Factor Can Regulate the Expression of Viral and Cellular Genes; G. Perini, M.R. Green. CREM: Transcriptional Pacemaker of the cAMP Response; J.S. Lee, et al. MADS-domain transcription Factor and Their Accessory Proteins (TCFs): Nuclear Targets for Growth Control Signals; M.A. Cahill, et al. Retinoblastoma Protein, Gene Expression, and Cell Cycle Control; J.C. Azizkhan, et al. Cyclin A-kinase Binding to and Regulation of the Function of a Growth-Promoting Transcription Factor; W. Krek, et al. Homeostatic Mechanisms Governing the Go hase as Defined by the Gas Genes; C. Schneider, et al. The TEL Gene and Human Leukemias; T.R. Golub, et al. Characterization of the TCLI Gene and Its Involvement in T-Cell Malignancies; L. Virgilio, et al. 3 Additional Articles. Index.

Since the full functionality of any given protein can only be understood in terms of its interaction with other, often regulatory proteins, this unique reference source covers all relevant protein domains, including SH2, SH3, PDZ, WW, PTB, EH, PH and PX. Its user-oriented concept combines broad coverage with easy retrieval of essential information, and includes a special section on Web-based tools and databases covering protein modules and functional peptide motifs.
Essential for the study of protein-protein interactions in vivo or in silico, and a prerequisite for successful functional proteomics studies.
With a prologue by Sir Tom Blundell.

The Great Lagoon is a central part of the Szczecin Lagoon, a major component in the Odra River estuary system. It is also an important European natural heritage site and one of the largest resting places for migratory birds in the Baltic Sea area. The first part of Wolnomiejski's and Witek's book gives a thorough overview of the most up-to-date knowledge of this region, including the assessment of its biological production. Based on these findings authors develop a food web model of the Polish part of the Szczecin Lagoon, identifying a total of 45 trophic-functional components. The model describes a variety of features ranging from the magnitude of consumption, to the amount of unassimilated food and export of individual system components, and serves as an invaluable source, helping researchers to estimate various ecological indicators of The Great Lagoon's ecosystem.

An in-depth text that explores the interface between analytical chemistry and trace evidence Analytical Techniques in Forensic Science is a comprehensive guide written in accessible terms that examines the interface between analytical chemistry and trace evidence in forensic science. With contributions from noted experts on the topic, the text features a detailed introduction analysis in forensic science and then subsequent chapters explore the laboratory techniques grouped by shared operating principles. For each technique, the authors incorporate specific theory, application to forensic analytics, interpretation, forensic specific developments, and illustrative case studies. Forensic techniques covered include UV-Vis and vibrational spectroscopy, mass spectrometry and gas and liquid chromatography. The applications reviewed include evidence types such as fibers, paint, drugs and explosives. The authors highlight data collection, subsequent analysis, what information has been obtained and what this means in the context of a case. The text shows how analytical chemistry and trace evidence can problem solve the nature of much of forensic analysis. This important text: Puts the focus on trace evidence and analytical science Contains case studies that illustrate theory in practice Includes contributions from experts on the topics of instrumentation, theory, and case examples Explores novel and future applications for analytical techniques Written for undergraduate and graduate students in forensic chemistry and forensic practitioners and researchers, Analytical Techniques in Forensic Science offers a text that bridges the gap between introductory textbooks and professional level literature.

This book discusses how we can inspire today's youth to engage in challenging and productive discussions around the past, present and future role of animals in science education. Animals play a large role in the sciences and science education and yet they remain one of the least visible topics in the educational literature. This book is intended to cultivate research topics, conversations, and dispositions for the ethical use of animals in science and education. This book explores the vital role of animals with/in science education, specimens, protected species, and other associated issues with regards to the role of animals in science. Topics explored include ethical, curriculum and pedagogical dimensions, involving invertebrates, engineering solutions that contribute to ecosystems, the experiences of animals under our care, aesthetic and contemplative practices alongside science, school-based ethical dialogue, nature study for promoting inquiry and sustainability, the challenge of whether animals need to be used for science whatsoever, reconceptualizing museum specimens, cultivating socioscientific issues and epistemic practice, cultural integrity and citizen science, the care and nurturance of gender-balanced curriculum choices for science education, and theoretical conversations around cultivating critical thinking skills and ethical dispositions. The diverse authors in this book take on the logic of domination and symbolic violence embodied within the scientific enterprise that has systematically subjugated animals and nature, and emboldened the anthropocentric and exploitative expressions for the future role of animals. At a time when animals are getting excluded from classrooms (too dangerous! too many allergies! too dirty!), this book is an important counterpoint. Interacting with animals helps students develop empathy, learn to care for living things, engage with content. We need more animals in the science curriculum, not less. David Sobel, Senior Faculty, Education Department, Antioch University New England

Home Ecophagus by Warren M. Hern is a wide-ranging look at the major problems for the survival of not just the human species, but all other species on Earth due to human activities over the past tens of thousands years. The title of the book indicates Hern's new name for the human species: "The man who devours the ecosystem." Over the course of its evolution, Hern observes, humans have evolved cultures and adaptations that have now become malignant and that the human species, at the global level, has all the major characteristics of a malignant neoplasm - converting all plant, animal, organic, and inorganic material into human biomass or its adaptive adjuncts and support systems. Hern contends that this process is incompatible with continued survival of the human species and most other species on the planet, offering a diagnosis and prognosis of the current environmental impasse.

This Revision Workbook provides a comprehensive collection of examination-style questions covering each topic from the WJEC Biology for A2 Level specification. // Ideal for examination preparation, exam question practice and for improving examination technique. // Enables students to build on their knowledge of key areas of study and develop their confidence in the subject. // Helps students understand what is required in an exam and develop the skills needed to be effective in an exam situation. // Includes advice on how students can refine their exam technique and improve their grade potential. // The helpful write-in format, together with the answers, enables students to check their progress as they work through the course.

The modern approach to teaching chemical biology Advanced Chemical Biology is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections. Every chapter is homogeneous in style and layout, consisting of a short historical introduction followed by a description of the underlying concepts and a selection of recent examples of how the concept has been turned into practice. The subdivision of the contents into core and supplemental chapters enables a flexible use in teaching, both for a one-semester and a two-semester course. Written by authors and editors coming from the leading scientific institutions that have developed the concepts and technologies for this discipline, Advanced Chemical Biology includes specific information on topics like: DNA function, synthesis and engineering, chemical approaches to genome integrity, and RNA function, synthesis, and probing Chemical approaches to transcription and RNA regulation in vivo, chemical biology of genome engineering, and peptide/protein synthesis and engineering Directed evolution for chemical biology, chemical biology of cellular metabolism, chemical biology of lipids, and protein post-translational modifications Chemical glycobiology, chemical and enzymatic modification of proteins, genetic code expansion, bio-orthogonal chemistry, and cellular imaging With its broad scope and focus on turning concepts into applications, Advanced Chemical Biology is an excellent starting point for anyone entering the field and looking for a guide to the wide range of available methods and strategies that chemical biology has to offer.

The technologies in data mining have been applied to bioinformatics research in the past few years with success, but more research in this field is necessary. While tremendous progress has been made over the years, many of the fundamental challenges in bioinformatics are still open. Data mining plays a essential role in understanding the emerging problems in genomics, proteomics, and systems biology. ""Advanced Data Mining Technologies in Bioinformatics"" covers important research topics of data mining on bioinformatics. Readers of this book will gain an understanding of the basics and problems of bioinformatics, as well as the applications of data mining technologies in tackling the problems and the essential research topics in the field. ""Advanced Data Mining Technologies in Bioinformatics"" is extremely useful for data mining researchers, molecular biologists, graduate students, and others interested in this topic.

The second volume in a series which aims to focus on advances in computational biology. This volume discusses such topics as: statistical analysis of protein sequences; progress in large-scale sequence analysis; and the architecture of loops in proteins.

Exam Board: WJEC, Eduqas Level: A-level Subject: Biology First Teaching: September 2015 First Exam: Summer 2017 Reinforce students' understanding throughout their course with clear topic summaries and sample questions and answers to help your students target higher grades. Written by experienced teacher Andy Clarke, our Student Guides are divided into two key sections, content guidance and sample questions and answers. Content guidance will: - Develop students' understanding of key concepts and terminology; this guide covers WJEC A-level Unit 3; Eduqas A-level Component 1 and Component 3. - Consolidate students' knowledge with 'knowledge check questions' at the end of each topic and answers in the back of the book. Sample questions and answers will: - Build students' understanding of the different question types, so they can approach each question with confidence. - Enable students to target top grades with sample answers and commentary explaining exactly why marks have been awarded.