This important new book provides the fundamental understanding of the peptide and protein drug delivery systems with a special focus on their nanotechnology applications. Addressing an increasing interest in peptide and protein drug delivery systems in both academic and industrial circles worldwide, this book fills the need for a comprehensive review and assessment of conventional and nonconventional routes of administration.

In Pediatric Behavioral Nutrition Factors: Environment, Education, and Self-Regulation, the editor carefully selected each chapter individually to provide a nuanced look at how environment, education, and self-regulation impact pediatric nutrition. All the various factors that intertwine with and influence nutrition are not yet known, and we often assume that poor nutrition is a socioeconomic issue. This is a massive, multifaceted topic. The articles in this compendium make clear that this simplistic assumption is not accurate; they were chosen to present as accurate a total image as possible, based on recent research. The final chapters offer innovative interventions that should become the foundation for ongoing investigation.

Food security and child malnutrition are at the forefront of our attention, both nationally and internationally. The chapters contained in this compendium include a range of methodologies-literature review, cross-sectional study, longitudinal study, case-control, and even a focus group!-all of which examine this urgent issue, revealing new perspectives and facets of information. The international roster of contributors present a nuanced look at food security and child malnutrition with research into food security measures in many nations around the world. The book is broken into several parts, covering defining food security food security, nutrition, and growth and development food security and mental and physical health food security and child obesity conclusion, with an information study from The Children's Healthwatch on household hardships, public programs, and their associations with the health and development of very young children The range of topics and information presented here will be valuable for those involved with food security advocacy, policymakers, researchers, social service professionals working children and families, and others.

This book is a thought-provoking assessment of assumptions inhibiting progress in comparative biology. The volume is inspired by a list generated years earlier by Donn Rosen, one of the most influential, innovative and productive comparative biologists of the latter 20th century. His list has assumed almost legendary status among comparative evolutionary biologists. Surprisingly many of the obstructing assumptions implicated by Rosen remain relevant today. Any comparative biologist hoping to avoid such assumptions in their own research will benefit from this introspective volume.

Praise for Computational Systems BiologyApproaches in Cancer Research: "Complex concepts are written clearly and with informative illustrations and useful links. The book is enjoyable to read yet provides sufficient depth to serve as a valuable resource for both students and faculty." - Trey Ideker, Professor of Medicine, UC Xan Diego, School of Medicine "This volume is attractive because it addresses important and timely topics for research and teaching on computational methods in cancer research. It covers a broad variety of approaches, exposes recent innovations in computational methods, and provides acces to source code and to dedicated interactive web sites." - Yves Moreau, Department of Electrical Engineering, SysBioSys Centre for Computational Systems Biology, University of Leuven With the availability of massive amounts of data in biology, the need for advanced computational tools and techniques is becoming increasingly important and key in understanding biology in disease and healthy states. This book focuses on computational systems biology approaches, with a particular lens on tackling one of the most challenging diseases - cancer. The book provides an important reference and teaching material in the field of computational biology in general and cancer systems biology in particular. The book presents a list of modern approaches in systems biology with application to cancer research and beyond. It is structured in a didactic form such that the idea of each approach can easily be grasped from the short text and self-explanatory figures. The coverage of topics is diverse: from pathway resources, through methods for data analysis and single data analysis to drug response predictors, classifiers and image analysis using machine learning and artificial intelligence approaches. Features Up to date using a wide range of approaches Applicationexample in each chapter Online resources with useful applications'

Assistive technologies for the old and people with disabilities is now a very active field of research. It also constitutes a very profitable market (expected to reach US $60 billion p.a. by 2018). The book covers key aspects of this important field and provides guidelines for developing assistive technologies in smart environments. The book also presents the new paradigm of open innovation used by the most prolific research teams around the world. The latest developments in the field are given. Overall this book will be a reference for researchers, practitioners and engineers.

Since the discovery of graphene, it has become one of the most widely and extensively studied materials. This book aims to summarize the progress in synthesis, processing, characterization and applications of a special group of nanocarbon materials derived from graphene or graphene related derivatives by using various strategies in different forms. More specifically, three forms of macrosized materials are presented, i.e., one-dimension or 1D (fibers, wires, yarns, streads, etc.), two-dimension or 2D (films, membranes, papers, sheets, etc.) and three-dimension or 3D (bulk, hydrogels, aerogels, foams, sponges, etc.). Seven chapters are included with the first chapter serving to introduce the concept, definition, and nomenclature of graphene, graphene oxide and their derivatives. The main topics are covered in Chapters 2-7. Although they have coherent connections, each chapter of them is designed such that they can be studied independently. The target readers of this book include undergraduate students, postgraduate students, researchers, designers, engineers, professors, and program/project managers from the fields of materials science and engineering, applied physics, chemical engineering, biomaterials, materials manufacturing and design, institutes, and research founding agencies.

The book provides an insight into the advantages and limitations of the use of fractals in biomedical data. It begins with a brief introduction to the concept of fractals and other associated measures and describes applications for biomedical signals and images. Properties of biological data in relations to fractals and entropy, and the association with health and ageing are also covered. The book provides a detailed description of new techniques on physiological signals and images based on the fractal and chaos theory. The aim of this book is to serve as a comprehensive guide for researchers and readers interested in biomedical signal and image processing and feature extraction for disease risk analyses and rehabilitation applications. While it provides the mathematical rigor for those readers interested in such details, it also describes the topic intuitively such that it is suitable for audience who are interested in applying the methods to healthcare and clinical applications. The book is the outcome of years of research by the authors and is comprehensive and includes other reported outcomes.

Food antioxidants are of primary importance for the preservation of food quality during processing and storage. However, the status of food depends on a balance of antioxidants and prooxidants occurring in food. Food Oxidants and Antioxidants: Chemical, Biological, and Functional Properties provides a single-volume reference on the effects of naturally occurring and process-generated prooxidants and antioxidants on various aspects of food quality. The book begins with a general introduction to oxidation in food and then characterizes the main oxidants present in food, including enzymatic oxidants. Chapters cover oxidation potential, mechanisms of oxidation of the main food components (proteins and lipids), addition of exogenous oxidants during food processing, and the effects of physical agents such as irradiation, freeze-thawing, and high hydrostatic pressure during processing. The book also discusses the effects of oxidation on sensory characteristics of food components and analyzes how oxidation and antioxidants affect the nutritive and health-promoting features of food components. The text examines natural antioxidants in food, including lesser-known ones such as amino acids and polysaccharides, antioxidants generated in food as a result of processing, mechanisms of antioxidant activity, and measurement of antioxidant activity of food components. It explores the bioavailability of curcuminoid and carotenoids antioxidants and presents case studies on natural food antioxidants, presenting novel extraction methods for preservation of antioxidant activity. The final chapters address functional antioxidant foods and beverages as well as general ideas on the effects of food on the redox homeostasis of the organism.

Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals. Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics. The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.

In 2010, esteemed researchers gathered at a workshop held at the Richardson Centre for Functional Foods and Nutraceuticals at the University of Manitoba in Winnipeg, Canada. Drawn from these proceedings, Canola and Rapeseed: Production, Processing, Food Quality, and Nutrition presents state-of-the-art information on the chemistry of the minor constituents of canola and rapeseed and their impact on human health. The book also identifies new areas of research and opportunities for the industrial application of functional foods and nutraceuticals from canola and rapeseed. Topics include: The historical development, properties, and performance of canola Characteristics and bioactives of sinapic acid derivatives and the decarboxylation pathways leading to their formation Canola protein processing High omega-9 canola oils and their future applications Modification of Brassica oilseeds Rapid analytical methods for measuring oil content The potential of ultrasound and supercritical fluid extraction for producing value-added by-products The processing of virgin rapeseed oils in Europe Extraction and application of canola protein The frying stability of high-oleic low-linolenic acid canola oils The potential of mustard oil for biodiesel The final chapters demonstrate the health benefits of canola, including antioxidant, antimutagenic, and anticancer properties. Authored by experienced researchers in the field, the book chapters have been expanded considerably to include a number of areas not contained in the original workshop, providing comprehensive coverage of the potential of this essential crop.

Is there a link between people's heart rate and blood pressure? Does the lead in petrol fumes affect the growth of roadside plants? The ability to expertly analyse statistical data is a crucial skill in the biological sciences - it is fundamental to fully understanding what your experiments are actually telling you and so being able to answer your research questions. Statistical and Data Handling Skills in Biology gives you everything you need to understand and use statistical tests within your studies and future independent research. Written in a straight-forward and easy to understand style it presents all of the tests you will need throughout your studies, and shows you how to select the right tests to get the most out of your experiments. All of this is done in the context of biological examples so you can see just how relevant a skill this is, and how becoming fully proficient will make you a more rounded scientist. This 4th edition has been thoroughly updated throughout and now includes detailed coverage of the free statistical package R studio and a new chapter on how to write about and present statistics in papers, theses and reports. The first chapter has also been revised to introduce students to the need for and ideas behind statistical analysis. Features * Clear explanation with step by step detail of how to carry out a wide range of statistical analyses will help you to quickly gain understanding and confidence in this essential area. * Useful decision charts will help you to select the right statistical test and gain confidence in answering your research questions. * Real world examples in each chapter will help you to develop an applied understanding of the full range of statistical techniques * Self-assessment problems scenarios at the end of each chapter enable you to practice applying your understanding of a technique, thereby improving your confidence in using numbers. Guided answers allow you to check your understanding. Statistical and Data Handling Skills in Biology 4th edition is ideal for any biomedic or environmental scientist getting to grips with statistical analysis for use in class on as part of independent study.

Allergy and Allergen Immunotherapy: New Mechanisms and Strategies is a valuable and comprehensive book that covers allergy and causative allergens and provides diagnostic and therapeutic aspects as well. With chapters from internationally recognized experts in the field, the book provides a balanced approach to enumerating pollen allergens as well as allergy diagnosis and therapeutic management and safety assessment of genetically engineered food allergens. The book features a special section on allergic diseases and allergens from tropical countries, including such countries such as India, Sri Lanka, Iran, and South Korea, giving the book a global appeal. The book is broken in the following sections: Epidemiology, Pathophysiology, and Diagnosis of Allergy Aerobiology and Allergic Diseases Pollen Allergy in the Tropics and Temperate Regions Allergy in Children Food Allergy Evaluation Allergen Immunotherapy and Anti IgE The book deals not only on basics of allergy and allergen immunotherapy but also discusses indoor environments and safety considerations of genetically modified food allergens. The first of its kind volume from the Indian subcontinent that caters to the needs of clinicians, aerobiologists, environmentalists, and regulatory agencies as well, the volume will be of immense interest for clinicians and patients of allergy as well as diagnostic and therapeutic management of allergy in tropics.

This book comprehensively addresses advanced nanofiber manufacturing based on electrospinning technology. The principles, relationships between process parameters and structure, morphology and performance of electrospun nanofibers and nanomaterials, and the methods for enhanced field intensity and uniform distribution are discussed. The electric field intensity and distribution during electrospinning is also analyzed based on finite element analysis on both the needle and the needleless electrospinning. Furthermore, the modification techniques for improved nanomaterials strength are covered, aiming to provide effective avenues towards the manufacture of stronger nanofiber or nanomaterial products.

This volume, the first of the two-volume Drug Delivery Approaches and Nanosystems series, presents a full picture of the state-of-the-art research and development in drug delivery systems using nanotechnology and its applications. It addresses the ever-expanding application of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. Many methods of drug delivery systems have been used, but very few of them have been validated for medical use. A major reason for the above situation, the editors believe, is the gap between academia and research, and the gap between academic research and real-time clinical applications and needs. This volume addresses that gap. This volume presents 12 chapters that provide information about the preparation and characterization of nanocomposite materials used in drug delivery systems; advanced research of carbon nanotubes, nanocomposite materials, and polymer-clay, ceramics, and silicate glass-based nanocomposites; and the functionality of graphene nanocomposites. The book also provides detailed information on the application of nanotechnology in drug delivery systems in health care systems and medicine. The book describes how nanostructures are synthesized and draws attention to wide variety of nanostructures available for biological research and treatment applications. This valuable volume provides a wealth of information that will be valuable to scientists and researchers, faculty, and students. Volume 2 of the two-volume series is subtitled Drug Targeting Aspects of Nanotechnology. The volumes are available separately or as a set.

This immensely valuable book provides a comprehensive, easy-to-understand, and up-to-date glossary of technical and scientific terms used in the fields of bioengineering and biotechnology, including terms used in agricultural sciences. The volume also includes terms for plants, animals, and humans, making it a unique, complete, and easily accessible reference. Scientific and Technical Terms in Bioengineering and Biological Engineering opens with an introduction to bioengineering and biotechnology and presents an informative timeline covering the important developments and events in the fields, dating from 7000 AD to the present, and it even makes predictions for developments up the year 2050. From ab initio gene prediction to zymogen and from agrobacterium to zoonosis, this volume provides concise definitions for over 5400 specialized terms peculiar to the fields of bioengineering and biotechnology, including agricultural sciences. The use of consistent terminology is critical in presenting clear and meaningful information, and this helpful reference manual will be essential for graduate and undergraduate students of biomedical engineering, biotechnology, nanotechnology, nursing, and medicine and health sciences as well as for professionals who work with medicine and health sciences.

Focusing on nanoparticulate nanocarriers and recent advances in the field of drug delivery, the volume begins with chapters that provide an informative introduction to polymeric nanoparticles-their general physicochemical features and characteristics, their applications in drug delivery systems, and the challenges involved. Specific applications are discussed, with attention paid to treatment of particular diseases and disorders and the targeting of specific organs. Part 2 looks at more specific applications and techniques of nanoparticulate nanocarriers for drug delivery, such as the use of magnetic nanoparticles, gold nanoparticles in therapeutics, and superparamagnetic iron oxide nanoparticles (SPIONs) for the treatment of cancer. Part 3 discusses lipid-based nanoparticulates for various applications, including skin care. The last section of the book explores some of the newer nanoarchitectures, including dendrimers in gene delivery and carbon nanotubes for drug delivery. Together, the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers and faculty and upper-level students, as well as for industry professionals.

Succeed in your biology course with this updated Sixth Edition of BIOLOGY TODAY AND TOMORROW WITHOUT PHYSIOLOGY. Packed with real-world applications, the book offers chunked content in a clear, straightforward writing style, beautiful art and a variety of in-text learning tools. The accompanying MindTap for Biology includes multimedia instruction, assessments, videos, personalized study tools and more. With this easy-to-read, engaging text, you'll learn about biology from the perspective of issues relevant to your daily life.

Multivariate Survival Analysis and Competing Risks introduces univariate survival analysis and extends it to the multivariate case. It covers competing risks and counting processes and provides many real-world examples, exercises, and R code. The text discusses survival data, survival distributions, frailty models, parametric methods, multivariate data and distributions, copulas, continuous failure, parametric likelihood inference, and non- and semi-parametric methods. There are many books covering survival analysis, but very few that cover the multivariate case in any depth. Written for a graduate-level audience in statistics/biostatistics, this book includes practical exercises and R code for the examples. The author is renowned for his clear writing style, and this book continues that trend. It is an excellent reference for graduate students and researchers looking for grounding in this burgeoning field of research.

Get Up to Speed on Many Types of Adaptive Designs Since the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the use of various adaptive design methods in clinical trials. New to the Second Edition Twelve new chapters covering blinded and semi-blinded sample size reestimation design, pick-the-winners design, biomarker-informed adaptive design, Bayesian designs, adaptive multiregional trial design, SAS and R for group sequential design, and much more More analytical methods for K-stage adaptive designs, multiple-endpoint adaptive design, survival modeling, and adaptive treatment switching New material on sequential parallel designs with rerandomization and the skeleton approach in adaptive dose-escalation trials Twenty new SAS macros and R functions Enhanced end-of-chapter problems that give readers hands-on practice addressing issues encountered in designing real-life adaptive trials Covering even more adaptive designs, this book provides biostatisticians, clinical scientists, and regulatory reviewers with up-to-date details on this innovative area in pharmaceutical research and development. Practitioners will be able to improve the efficiency of their trial design, thereby reducing the time and cost of drug development.

This new edition bridges the gap between its predecessor, which emphasized conventional methods, and subsequent advances in analytical methodologies. Researchers and analysts strive to keep up with advances in microbiological methods. Although many techniques appear regularly in scientific literature, only a few of these are used routinely by analysts and even fewer are useable in teaching laboratories. In the time since the publication of the first edition, the authors of this book have screened many new published analytical methods for suitability as laboratory exercises. The new edition not only implements new and advanced analytical methods, but also improves currently used techniques. Since publication of the first edition, new selective and highly differential media have become available commercially. Some of the previous laboratory exercises included rapid detection kits that are no longer available from the manufacturer. Basic concepts have been modified to better reflect emerging food safety concerns. In the new laboratory manual, these issues are addressed in a creative manner.

First published in 1982: This publication should be an invaluable tool to food technologists, dieticians, and nutritionalists, as well as to livestock producers and persons engaged in production, processing, and formulation of animal feeds.

This book is based upon the collaborative efforts of the Ontogenetics Process Group (OPG) - an interdisciplinary, multi-institutional, multi-national research group that began meeting in 2017 to explore new and innovative ways of thinking the problem of complexity in living, physical, and social systems outside the algorithmic models that have dominated paradigms of complexity to date. For all the descriptive and predictive power that the complexity sciences offer (the ability to compute feedback systems, recursive networks, emergent dynamics, etc.), they also presume that the living world in all of its modalities (biological, semiotic, economic, affective, social) can be reduced to finite schema of description that delimits in advance all possible outcomes. What is proposed in this volume are conceptual architectures for the living that are not only irreducible to physico-mathematical frames of reference, but that are also as vital as the phenomena they wish to express. In short: life is more complex than complexity. What emerges from this engagement is not the ascendance of a new transcendental principle (or, what amounts to the same thing, a foundational bedrock) derived from the physico-mathematical sciences, but just the opposite: a domain in which the ontological and the epistemological domains enter a zone of strange (and unavoidable) entanglement. The chapters in this book were originally published as a special issue of Angelaki.

The utilization of footwear impression evidence continues to evolve with new materials, equipment and techniques, providing an increased ability to detect, record, enhance, and examine this form of evidence. Recently developed technology now allows investigators to more efficiently or, in some cases, instantly link multiple crime scenes where impressions have been produced by the same perpetrator. Forensic Footwear Evidence covers a wide range of relevant topics, including historical references, general information about the formation and investigative use of footwear impressions, and the best practices and considerations that apply to the recovery, enhancement, and examination of this evidence. Drawing on the author's 44 years of acquired knowledge and experience, it is the most comprehensive and authoritative text published to date on this topic. Highlighted topics covered within the book include Three chapters covering footwear manufacturing Shoe grading, sizing, and the forensic application of sizing information Examination and reporting procedures Casting impressions in snow Barefoot evidence Topics of interest for both prosecution and defense attorneys The book includes more than 300 color photographs and illustrations throughout, as well as case examples that apply theoretical concepts to the real world. A single, complete reference on the subject, Forensic Footwear Evidence presents a wide range wealth of information that will serve as an invaluable reference to novice and experienced examiners, crime scene technicians, investigators, and prosecution and defense counselors alike.

This superb CGP Exam Practice Workbook is the perfect companion for Year 1 & 2 of OCR A A-Level Biology. It's packed with ultra-realistic exam questions covering every topic students need to know, including a section of mixed (synoptic) questions. We've added in exam tips throughout to make sure there are no unpleasant surprises in their exams! To round things off there are fully worked answers and mark schemes for every question. For study notes and even more practice don't miss the CGP OCR A A-Level Biology Complete Revision & Practice guide (9781782942993).