Scent and Chemistry Odor impressions have cast a spell over mankind since the dim and distant past. But even today, we are -consciously or subconsciously- guided by our sense of smell and the chemistry behind it. The prominent fragrance chemists Gunther Ohloff, Wilhelm Pickenhagen and Philip Kraft convey the scientist, the perfumer, and the interested layman with a vivid and up-to-date picture of the chemistry of odorants and the research in odor perception. In this second thoroughly revised and updated edition they are joined by creative perfumer Fanny Grau, a rising master in this metier, who complements the scientific treatise by a concise introduction to the art of perfumery and its composition techniques. Besides this new chapter on the creative aspects of perfumery, the book details on the molecular basis of olfaction, olfactory characterization of perfumery materials, structure-odor relationships, the chemical synthesis of odorants, and the chemistry of essential oils and odorants from the animal kingdom, backed up by many perfume examples and historical aspects. It will serve as a thorough introductory text for everyone interested in the molecular world of odors.

Prescott's Principles of Microbiology provides a balanced, comprehensive introduction to all major areas of microbiology. Because of this balance, Prescott's Principles of Microbiology is appropriate for microbiology majors and mixed majors courses. The authors have focused on readability, artwork, and the integration of several key themes, including evolution, ecology and diversity, throughout the text, making an already superior text even better.

This book examines the challenges and impacts of poor diets and nutrition from current food systems and the potential contribution of biodiversity and ecosystem services in addressing these problems. There is a strong need for a multi-level, cross-sectoral approach that connects food biodiversity conservation and sustainable use to address critical problems in our current food systems, including malnutrition. Building on research from the Biodiversity for Food and Nutrition Project (BFN), which aims to better link biodiversity, diets and nutrition, the book presents a multi-country, cross-sectoral analysis of initiatives that have promoted local food biodiversity in four countries: Brazil, Kenya, Turkey and Sri Lanka. This book offers a comprehensive summary of the BFN Project results in each of the four countries along with lessons learned and how this work could be upscaled or applied in other regions. It argues that the strategic promotion and use of food biodiversity is critical in uniting attempts to address conservation, nutrition and livelihood concerns. The book is structured around chapters and case studies encompassing the BFN Project with specific experiences related by partners who played key roles in the work being done in each country. By offering a comparative view capable of furthering dialogue between the respective countries, it is also meant to connect the individual cases for a "greater than the sum of its parts" effect. This means consideration of how localized activities can be adapted to more countries and regions. Therefore, the book addresses global issues with a foot planted firmly in the grounded case study locations. This book will be of great interest to policymakers, practitioners and NGOs working on food and nutrition, as well as students and scholars of agriculture, food systems and sustainable development.

The story of postwar Greece holds invaluable lessons for many developing countries today. In 1947 Greece had just emerged from a decade of war and strife; its villagers were demoralized and fleeing rural life for the cities; and its farms were unable to produce adequate crops to feed its people. In less than forty years Greece has become a major ex

"There's no better way to learn Year 2 of the AQA A-Level Biology course than with this new and improved CGP Complete Revision & Practice book. It's perfect for reference throughout the year, and preparing for the final exams! It has straightforward study notes, helpful examples and full-colour diagrams. We've included more challenging exam practice than ever before with plenty of practice questions and exam-style questions (with detailed answers) for every topic - plus a section of mixed (synoptic) practice testing different parts of the course. To round things off there are sections of in-depth advice on Practical Skills and how to pick up top marks in the exams. There's even a free Online Edition of the whole book - just use the code printed inside the book to access it on your PC, Mac or tablet. For even more practice don't miss CGP's Year 2 of A-Level Biology Exam Practice Workbook (9781782949091). "

Physiology of Sport and Exercise, Eighth Edition With HKPropel Access, continues its legacy as a top physiology textbook and favorite of instructors and students alike. Combining research with extensive visual aids, this resource offers a simple way for students to explore the body’s response to various types and intensities of exercise and sports. Written by a team of distinguished researchers, all past presidents of the American College of Sports Medicine, this eighth edition has been updated based on the most recent standards and guidelines in the field of exercise physiology. The text builds upon the previous edition’s high standards for illustrations, photos, and medical artwork with a refreshed, more sophisticated look to encourage a deep understanding of complex topics. Multimedia components delivered through HKPropel include 26 animations that offer a dynamic way to experience physiological concepts and 66 audio clips that offer explanations of elaborate physiological processes. Leaders in the field help students connect theoretical and practical concepts in 27 video clips. Learning assessments and key term flash cards offer additional interactive opportunities to explore the content, and QR codes throughout the text notify students when complementary digital components are available. Physiology of Sport and Exercise, Eighth Edition, features the following enhancements based on the latest research in the field: Additional information on cellular signaling and molecular adaptations Expanded content on obesity and sports nutrition Reorganized and expanded chapters on energy expenditure and exercise prescription that make the content more accessible to students Extensive updates on important topics, including bioinformatics and big data, reading research articles, molecular mechanisms of increased protein synthesis, muscle cramps, and mitochondrial oxidation Updated Research Perspective sidebars that emphasize emerging findings in the field and a Research Perspectives Finder to help students locate key content quickly As in previous editions, readability and ease of understanding make Physiology of Sport and Exercise different from other physiology resources. Unique learning aids, including chapter-opening outlines and review boxes throughout each chapter, will help students focus on the major concepts addressed. Study questions and a list of key terms at the end of each chapter provide opportunities for recall and self-assessment. A comprehensive glossary and lists of common abbreviations and conversions provide easy reference for students. Physiology of Sport and Exercise has been a pivotal textbook in the field of exercise physiology. Through this edition’s dynamic and interactive learning activities, easy-to-follow layouts, and research-oriented content enriched with visual supplements, students and instructors will find this an invaluable resource for their continued education. Note: A code for accessing HKPropel is included with this ebook.

The world is awash in data. This volume of data will continue to increase. In the pharmaceutical industry, much of this data explosion has happened around biomarker data. Great statisticians are needed to derive understanding from these data. This book will guide you as you begin the journey into communicating, understanding and synthesizing biomarker data. -From the Foreword, Jared Christensen, Vice President, Biostatistics Early Clinical Development, Pfizer, Inc. Biomarker Analysis in Clinical Trials with R offers practical guidance to statisticians in the pharmaceutical industry on how to incorporate biomarker data analysis in clinical trial studies. The book discusses the appropriate statistical methods for evaluating pharmacodynamic, predictive and surrogate biomarkers for delivering increased value in the drug development process. The topic of combining multiple biomarkers to predict drug response using machine learning is covered. Featuring copious reproducible code and examples in R, the book helps students, researchers and biostatisticians get started in tackling the hard problems of designing and analyzing trials with biomarkers. Features: Analysis of pharmacodynamic biomarkers for lending evidence target modulation. Design and analysis of trials with a predictive biomarker. Framework for analyzing surrogate biomarkers. Methods for combining multiple biomarkers to predict treatment response. Offers a biomarker statistical analysis plan. R code, data and models are given for each part: including regression models for survival and longitudinal data, as well as statistical learning models, such as graphical models and penalized regression models.

Features Represents the first book to provide comprehensive coverage of model-assisted designs for various types of dose-finding and optimization clinical trials Describes the up-to-date theory and practice for model-assisted designs Presents many practical challenges and issues arising from early-phase clinical trials Illustrates with many real trial applications Offers numerous tips and guidance on designing dose finding and optimization trials Provides step-by-step illustration of using software to design trials Develops a companion website (www.trialdesign.org) to provide easy-to-use software to assist learning and implementing model-assisted designs.

Blood is life, its complex composition is finely attuned to our vital needs and functions. Blood can also signify death, while 'bloody' is a curse. Arising from the 2021 Darwin College Lectures, this volume invites leading thinkers on the subject to explore the many meanings of blood across a diverse range of disciplines. Through the eyes of artist Marc Quinn, the paradoxical nature of blood plays with the notion of self. Through those of geneticist Walter Bodmer, it becomes a scientific reality: bloodlines and diaspora capture our notions of community. The transfer of blood between bodies, as Rose George relates, can save lives, or as we learn from Claire Roddie can cure cancer. Tim Pedley and Stuart Egginton explore the extraordinary complexity of blood as a critical biological fluid. Sarah Read examines the intimate connection between blood and womanhood, as Carol Senf does in her consideration of Bram Stoker's novel Dracula.

Published in 1994, this book examines a small segment of the medical technology innovation process to characterize the manner in which the federal government influences small business-based investigators to participate or withdraw from the medical technology innovation process. It provides an historical account of the federal government's involvement in biomedical technology research and development, and traces the social and economic significance of this involvement.

The United States spends more than 17% of its GDP on health care, while other developed countries throughout the world average 8.7% of GDP on healthcare expenditures. By 2028, that percentage in the United States is projected to be 19.7% of GDP. Yet all this spending apparently doesn't equate to value, quality, or performance. Among 11 high-income countries the United States healthcare industry ranked last during the past seven years in four key performance categories: administrative efficiency, access to care, equity, and healthcare outcomes. This book presents the implantable medical device (IMD) supply chain ecosystem as a microcosm of how these challenges of affordability and healthcare outcomes are created and are allowed to fester. The IMD Spiderweb, as the authors call it, is exposed as an example of how a wide range of participants-including physicians, health system CEOs, group purchasing organizations, health insurance companies and supply chain executives-become ensnared in a web designed to benefit only one player. The book also details the affordability challenges in the industry caused by the past and current IMD ecosystem and presents a model for meeting those challenges. The result is that the true cost of IMDs is hidden, while hospitals and health systems in the United States pay as much as six times more for some IMDs as their counterparts do in Europe, and prices for the same model of a particular IMD vary wildly even among different U.S. hospitals. While there is a fascination with the latest and greatest device there is also a shroud around visibility into how these products-which include cardiac rhythm management devices such as pacemakers and orthopedic implants such as knees and hips-have performed and are likely to perform in patients. The costs continue to rise not only in healthcare expenditures, but also in death and disability. The IMD spiderweb is presented as a prime lesson in the challenges in healthcare affordability and outcomes that occur throughout the entire healthcare industry. It is also put forward as an opportunity. The story behind how these challenges arose and are deepened by the ecosystem provides a foundation for solutions.

This fantastic CGP Exam Practice Workbook is the perfect companion for Year 1 & 2 of AQA A-Level Biology. It's packed with ultra-realistic exam questions covering every topic students need to know, including a section of mixed (synoptic) questions. We've added in exam tips throughout to make sure there are no unpleasant surprises in their exams! To round things off there are fully worked answers and mark schemes for every question. For study notes and even more practice don't miss the CGP AQA A-Level Biology Complete Revision & Practice guide (9781789080261).

Over the past several years, myriad manuals on crime scene investigations have been published with each focusing on select, or partial, aspects of the investigation. Crime scene investigation, done right, is a multi-faceted process that requires various forms of evidence to be collected, examined, and analyzed. No book available has addressed procedures to present global best practices by assembling a collection of international experts to address such topics. Manual of Crime Scene Investigation is a comprehensive collaboration of experts writing on their particular areas of expertise as relates to crime scenes, evidence, and crime scene investigation. The book outlines best practices in the field, incorporating the latest technology to collect, preserve, and enhance evidence for appropriate analysis. Various types of forensic evidence are addressed, covering chain of custody, collection, and utility of such evidence in casework, investigations, and for use in court. The approach, and use of international contributor experts, will appeal to a broad audience and be of use to forensic practitioners, and the forensic science community worldwide. Key features: * Assembles an international team of contributing author experts to present the latest developments in their crime scene field of specialty * Examines global best practices and what are consistently the most reliable tactics and approach to crime scene evidence collection, preservation, and investigation * Provides numerous photographs and diagrams to clearly illustrate chapter concepts Manual of Crime Scene Investigation serves as a vital resource to professionals in police science and crime scene investigations, private forensic institutions, and academics researching how better real-world application of techniques can improve the reliability and utility of evidence upon forensic and laboratory analysis.

One of Nature's most important talents is evolutionary development of systems capable of molecular recognition: distinguishing one molecule from another. Molecular recognition is the basis for most biological processes, such as ligandreceptor binding, substrate-enzyme reactions and translation and transcription of the genetic code and is therefore of universal interest. Over the past four decades, researchers have been inspired by Nature to produce biomimetic materials with molecular recognition properties, by design rather than by evolution. A particularly exciting area of biomimetics is Molecular Imprinting, which can be defined as process of template-induced formation of specific recognition sites (binding or catalytic) in a material where the template directs the positioning and orientation of the material's structural components by a self-assembling mechanism. The material itself could be oligomeric (the typical example is DNA replication process), polymeric (organic MIPs and inorganic imprinted silica gels) or 2-dimensional surface assembly (grafted monolayers). Essentially the current progress in the field of molecular imprinting is a result of fundamental achievements made by more than a hundred groups working in the areas of non-covalent and reversible covalent imprinting. The goal of this title is to capture this momentum and publish a new book that will reflect the current situation in this rapidly evolving technology. Very few of the tens of reviews already published on this subject present a critical analysis of the technological aspects of molecular imprinting. Leaders in this field have been approached with requests to provide their views and analyses of specific areas of design, characterization and application of these polymers. The main body of Molecular Imprinting of Polymers starts with chapters covering polymer design, synthesis, and characterization that are prepared by well-recognized experts such as Andrew Mayes and Natalia Perez-Moral, Claud

This book focuses on the impact of waste disposal to land, providing an outline of the underpinning knowledge of processes associated with contaminant sorption, transport, and plant uptake. It presents case studies highlighting waste management technologies used in the Australasia-Pacific region.

More than 20 billion dollars worth of biopharmaceuticals are scheduled to go off-patent by 2006. Given the strong political impetus and the development of technological tools that can answer the questions regulatory authorities may raise, it is inevitable that the FDA and EMEA will allow biogeneric or biosimilar products. Even with all the regulatory wrinkles yet to be ironed out, generic or similar biological products are soon to become a reality. Handbook of Biogeneric Therapeutic Proteins is the first book to review and analyze the status of biotechnology, regulatory environment, manufacturing methodologies, testing requirements and intellectual property issues. The book provides complete and thorough coverage of the regulatory and technological challenges of developing generic therapeutic proteins and how to prepare detailed regulatory and manufacturing plans and policies. The author includes information on establishing a manufacturing system, securing regulatory approval, and setting up facilities to manufacture raw materials and prepare finished products. He also supplies details about the Chemistry, Manufacturing, and Controls (CMC) section of the FDA's New Drug Application for Biological Products. In brief, the book supplies everything a manufacturer would need to plan the development of biogeneric products and complete the process of regulatory filing. Waiting for the FDA to issue guidelines is a mistake. The scramble to catch up could leave your company way behind in the game. Your organization needs to begin developing and characterizing genetically modified cells now and to complete initial GMP production runs through a CRO to get ready for the newer testing the FDA might impose. Packed with tables and figures that provide speedy access to precise, timely data, including full formulation details on all FDA approved biological product, this book contains a broad range of resource materials about suppliers, manufacturers, and testing faciliti

This unique book examines the beneficial aspects of animal waste as a soil resource - not simply as an agricultural by-product with minimal practical use. Topics include o types of livestock waste - swine, poultry, dairy o methods and management of waste utilization o storage, handling, processing and application of animal waste o supplying crop nutrients o economics of waste utilization o new modeling and management techniques o nonpoint source pollution, water quality, leaching, and air quality.

Polymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume consists of twenty-two recent research-based reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports were prepared by top scientists in the field and are based on current research conducted at leading laboratories in the U.S.A., Europe, and Asia. These 22 chapters report the latest information in the application of polymers to biological systems.

The discovery of Toll-like receptors (TLRs) in the late 1990s ushered in a new age of discovery for innate immunity. The importance of TLRs for immunology and biomedical research was recognized with the Nobel Prize for Medicine or Physiology in 2011. The prize was shared by three scientists: Ralph Steinman (for the discovery of dendritic cells, which express TLRs and whose activation by them provides a link between innate and adaptive immunity), Jules Hoffman (who made the pioneering observation of Toll in fruit fly anti-fungal immunity) and Bruce Beutler (who uncovered the role of TLR4 in the response to LPS). Work on TLRs inspired many researchers, and led to a search for other receptors in innate immunity. There are now several additional families of such receptors known, notably RIG-I-like receptors (RLRs), C-type lectin receptors (CLRs) and AIM2-like receptors (ALRs). A notable feature is the detection of nucleic acids from pathogens, but also from host cells in certain contexts, particularly in autoimmune diseases. Nucleic Acid Sensors and Antiviral Immunity presents a timely and extensive account of the detection of nucleic acids in infection and inflammation. We have chapters by Beutler, Hoffman and Shizuo Akira, who is the most cited immunologist of the past ten years, for his work on innate immunity, which gives us an indication of the importance of the field. Several other pioneers in the field present comprehensive and highly lucid up-to-date accounts of their particular interests, revealing the large amount of activity in the past few years, as the literature continues to grow and become ever more complex. The fly yet again provides new insights, and anti-viral mechanisms in this key model organism are described. Other topics include the ability of viruses such as poxviruses, hepatitis C virus and HIV to interfere with detection and signalling; new insights into signalling including subcellular localization of signalling proteins, complex regulation o

The study of drug action has benefitted greatly from the development and use of in vivo model systems. In model systems, manipulations and observations can be more rigorously controlled and screens of novel therapeutic agents can be more safely conducted. No single model system provides all of the possible advantages. At one end, mammalian models allow the study of complex behavioral patterns and the most complex of cognitive functioning. At the other end, models using simple organisms such as C. elegans allow the application of the most sophisticated and recent molecular biology and other innovative techniques. The major purpose of the present book is to highlight another model-one that we believe occupies a uniquely important position.

First suggested in 1863 by Marey, abdominal compartment syndrome, (ACS), is a constellation of the physiologic sequelae of increased intra-abdominal pressure, (IAP), termed intra-abdominal hypertension, (IAH). Recent observations suggest an increasing frequency of this complication in all types of patients, neonates to the elderly and in diverse clinical conditions, surgical to non-surgical. Even chronic elevations of IAP seem to effect the various organ systems in the body. Despite its obvious clinical implications, not enough attention is paid to IAP and IAH. ACS is still not uniformly appreciated or diagnosed. Only a few medical and surgical intensivists believe in the concept of IAH and actively attempt its prevention and treatment. The result, as is strongly substantiated by retrospective and prospective data, is a successful reduction in organ failures and mortality. Abdominal compartment syndrome is a condition that, until recently, has been poorly appreciated, despite important potential implications for all organ systems. Recent interest has helped clarify the local and systemic effects of increased intra-abdominal pressure and heightened awareness of the importance of early recognition and treatment. This book, written by international experts in the field, follows the first World Congress on Abdominal Compartment Syndrome held in Noosa, Australia in December 2004, and provides an excellent update on this topical subject. Comprehensively constructed, this book covers all key aspects of the syndrome, from definitions and diagnosis to monitoring and management, and is supported throughout by appropriate and ample illustrations. Many of the detrimental consequences of abdominal compartment syndrome are reversible with appropriate and timely intervention, and, although many questions remain unanswered regarding this condition, this book provides a welcome and detailed source of current information and opinion on abdominal compartment syndrome, which will be he

There is no doubt that the study of the muscular dystrophies in recent years has been exciting and rewarding. It has attracted the attention of many investigators of international repute, and this is reflected in the various contributions to this volume. Molecular Mechanisms of Muscular Dystrophies represents a personal collection of chapters covering a spectrum of muscular dystrophies and one myopathy that represent most of the major muscular dystrophies, and, in particular, those where a molecular understanding of the underlying mechanisms is most advanced, rather than a comprehensive treatise on every muscular dystrophy so far characterized.

Thoroughly revised and updates, this new edition of Ophthalmic Toxicology retains its uniqueness in covering all aspects of ophthalmic toxicology. With chapters from leading authorities incorporating the latest developments in the field, including a new chapter on the molecular basis of ophthalmic toxicity, this edition covers such topics as: *the history of ophthalmic toxicology *specific actions/affinities of ophthalmic poisons to various eye tissues and to animal species *research methods in vivo and in vitro *ophthalmic toxicities of representative chemicals via systemic and/or local delivery *medical treatment of chemical ocular injuries This one-of-a-kind reference on ophthalmic toxicology will be invaluable to all professionals in academia, industry, clinics, research laboratories, and government agencies.

Soil degradation has serious global impacts on agronomic, economic, and sociopolitical conditions, however, statistics regarding the degree of these impacts has been largely unreliable. This book aims to standardize the methodology for obtaining reliable and objective data on soil degradation. It will also identify and develop criteria for assessing the severity of soil degradation, providing a realistic scenario of the problem.

Foreseeing and planning for all of the possibilities and pitfalls involved in bringing a biotechnology innovation from inception to widespread therapeutic use takes strong managerial skills and a solid grounding in biopharmaceutical research and development procedures. Unfortunately there has been a dearth of resources for this aspect of the field. Until now. Focusing on the management of healthcare-related biotech, from conception through the product's regulatory approval and entire life cycle, Healthcare Biotechnology: A Practical Guide provides a practical, applicable resource to assist all health-care related biotech professionals in their day-to-day activities from the lab to the boardroom. Divided into six sections, the book begins with current systems and recent progress and controversy, major players and products, and a comparison with the pharmaceutical industry. It covers intellectual property protection and management, the innovation cycle, patent application, commercialization, and competition. Coverage includes funding, partnering, cash-intensive activities, financing alternatives, and the complexities of alliance implementation and management. It highlights research, development, and biomanufacturing; and examines clinical trial design and regulations; "fast-track" approvals; and patient recruitment as well as production platforms and processes, costs, strategies, and timelines. It investigates marketing including planning, promotion, pricing, supply chain management, and bio-brand lifecycle management. It concludes with tips on running the business, offering diverse biobusiness models and reasonable expectations from inception through maturity and decline. An indispensible guide, this book offers more than 40 figures, 220 tables, and 180 references as well as a list of abbreviations and a business plan outline. Each chapter contains 10 questions to reinforce the material covered and 10 exercises