Uses a relatively small number of key principles, in conjunction with a modest repertoire of statistical techniques to help the reader master the essential statistical aspects of clinical trials Includes a wealth of famous examples in cancer, cardiovascular diseases, and infectious diseases Readers with a familiarity of undergraduate statistics will be well-prepared for the book. When more advanced results are needed, they will be motivated in a heuristic way.

-- Embarking on a PhD is daunting as, for most students, it will be their first experience working within the academic system. This guide offers a helping hand during and when making decisions about how to move on with their career, specifically in the biological sciences. -- Examples are tailored to biological science, offering a unique reference for PhD students in these disciplines. -- The author has authored more than 200 peer reviewed scientific papers and book chapters, and five books. He has been the Editor-in-Chief of an ISI journal for 9 years, and has graduated more than 20 postgraduate students. His blog on writing and publishing in biological sciences is read by thousands globally. -- The book is directed toward writing, considered by many to be the most difficult aspect of a PhD. It delves into the practical detail of each aspect from Abstract to Supplementary material. -- Most of the 25,000 universities in the world have postgraduates in biological sciences, and emerging economies, such as India and China, will have special interest in this book as their academic systems still fall outside of the academic mainstream. -- The book has many short, easy to read, chapters which are interconnected to provide a comprehensive treatment of each subject.

Introduces important recent technological advancements in the field Describes the various techniques, platforms, and tools used in biomedical deep learning systems Includes informative case studies that help to explain the new technologies

The World Health Organization estimates that there are 2.1 billion individuals with obesity globally. Nearly three quarters of adults in the United States are overweight or obese. The average individual with obesity cuts ten years off their life expectancy, yet less than 40% of physicians routinely counsel individuals concerning the adverse health consequences of obesity. Obesity Prevention and Treatment: A Practical Guide equips healthcare practitioners to include effective weight management counselling in the daily practice of medicine. Written by lifestyle medicine pioneer and cardiologist, Dr. James Rippe and obesity expert Dr. John Foreyt, this book provides evidence-based discussions of obesity and its metabolic consequences. A volume in the Lifestyle Medicine Series, it provides evidence-based information about the prevention and treatment of obesity through lifestyle measures, such as regular physical activity and sound nutrition, as well as the use of new medications or bariatric surgery available to assist in weight management. Provides a framework and practical strategies to assist practitioners in safe and effective treatments of obesity. Contains information explaining the relationship between obesity and increased risk of heart disease, diabetes, cancer, osteoarthritis, and other chronic conditions. Chapters begin with bulleted key points and conclude with a list of Clinical Applications. Written for practitioners at all levels, this user-friendly, evidence-based book on obesity prevention and treatment will be valuable to practitioners in general medicine or subspecialty practices.

Large biological data, which are often noisy and high-dimensional, have become increasingly prevalent in biology and medicine. There is a real need for good training in statistics, from data exploration through to analysis and interpretation. This book provides an overview of statistical and dimension reduction methods for high-throughput biological data, with a specific focus on data integration. It starts with some biological background, key concepts underlying the multivariate methods, and then covers an array of methods implemented using the mixOmics package in R. Features: Provides a broad and accessible overview of methods for multi-omics data integration Covers a wide range of multivariate methods, each designed to answer specific biological questions Includes comprehensive visualisation techniques to aid in data interpretation Includes many worked examples and case studies using real data Includes reproducible R code for each multivariate method, using the mixOmics package The book is suitable for researchers from a wide range of scientific disciplines wishing to apply these methods to obtain new and deeper insights into biological mechanisms and biomedical problems. The suite of tools introduced in this book will enable students and scientists to work at the interface between, and provide critical collaborative expertise to, biologists, bioinformaticians, statisticians and clinicians.

The dream of humanism is to cleanly discard of humanity's animal remains along with its ecological embeddings, evolutionary heritages and futures, ontogenies and phylogenies, sexualities and sensualities, vulnerabilities and mortalities. But, as the contributors to this volume demonstrate, animal remains are everywhere and so animals remain everywhere. Animal remains are food, medicine, and clothing; extractive resources and traces of animals' lifeworlds and ecologies; they are sites of political conflict and ontological fear, fetishized visual signs and objects of trade, veneration, and memory; they are biotechnological innovations and spill-over viruses. To make sense of the material afterlives of animals, this book draws together multispecies perspectives from literary criticism and theory, cultural studies, anthropology and ethnography, photographic and film history, and contemporary art practice to offer the first synoptic account of animal remains. Interpreting them in all their ubiquity, diversity, and persistence, Animal Remains reveals posthuman relations between human and non-human communities of the living and the dead, on timescales of decades, centuries, and millennia.

This book provides an exploration of the ethics of cardiology practice. It provides a variety of frameworks for analyzing ethical issues that arise in cardiovascular medicine. Cardiovascular medicine-the diagnosis and treatment of congenital and acquired diseases of the heart, major arteries, and veins-has seen rapid change in diagnosis, treatment, and the organization of practice in the last half of the twentieth and the beginning of the twenty first century. The complexity of these developments has resulted in increasing subspecialization, and many practitioners are challenged to stay abreast with the latest developments in cardiology. These changes also bring with them various ethical challenges. The chapters in this volume are divided by five broad areas of practice: beginning-of-life, end-of-life, transplantation and allocation of expensive or scarce resources, professionalism, and research. The case-based approach presented across the volume provides a perspective that will allow readers to reason through current and future ethical issues as they arise in this rapidly changing field. Ethical Issues in Cardiovascular Medicine will be of interest to researchers working in bioethics, clinical ethics, and the philosophy of medicine, as well as practicing physicians, nurses, and students who work in cardiovascular medicine.

The concept of multivalued linear operators-or linear relations-is the one of the most exciting and influential fields of research in modern mathematics. Applications of this theory can be found in economic theory, noncooperative games, artificial intelligence, medicine, and more. This new book focuses on the theory of linear relations, responding to the lack of resources exclusively dealing with the spectral theory of multivalued linear operators. The subject of this book is the study of linear relations over real or complex Banach spaces. The main purposes are the definitions and characterization of different kinds of spectra and extending the notions of spectra that are considered for the usual one single-valued operator bounded or not bounded. The volume introduces the theory of pseudospectra of multivalued linear operators. The main topics include demicompact linear relations, essential spectra of linear relation, pseudospectra, and essential pseudospectra of linear relations. The volume will be very useful for researchers since it represents not only a collection of a previously heterogeneous material but is also an innovation through several extensions. Beginning graduate students who wish to enter the field of spectral theory of multivalued linear operators will benefit from the material covered, and expert readers will also find sources of inspiration.

Threat actors, be they cyber criminals, terrorists, hacktivists or disgruntled employees, are employing sophisticated attack techniques and anti-forensics tools to cover their attacks and breach attempts. As emerging and hybrid technologies continue to influence daily business decisions, the proactive use of cyber forensics to better assess the risks that the exploitation of these technologies pose to enterprise-wide operations is rapidly becoming a strategic business objective. This book moves beyond the typical, technical approach to discussing cyber forensics processes and procedures. Instead, the authors examine how cyber forensics can be applied to identifying, collecting, and examining evidential data from emerging and hybrid technologies, while taking steps to proactively manage the influence and impact, as well as the policy and governance aspects of these technologies and their effect on business operations. A world-class team of cyber forensics researchers, investigators, practitioners and law enforcement professionals have come together to provide the reader with insights and recommendations into the proactive application of cyber forensic methodologies and procedures to both protect data and to identify digital evidence related to the misuse of these data. This book is an essential guide for both the technical and non-technical executive, manager, attorney, auditor, and general practitioner who is seeking an authoritative source on how cyber forensics may be applied to both evidential data collection and to proactively managing today's and tomorrow's emerging and hybrid technologies. The book will also serve as a primary or supplemental text in both under- and post-graduate academic programs addressing information, operational and emerging technologies, cyber forensics, networks, cloud computing and cybersecurity.

Thoroughly updated throughout, A First Course in Linear Model Theory, Second Edition is an intermediate-level statistics text that fills an important gap by presenting the theory of linear statistical models at a level appropriate for senior undergraduate or first-year graduate students. With an innovative approach, the authors introduce to students the mathematical and statistical concepts and tools that form a foundation for studying the theory and applications of both univariate and multivariate linear models. In addition to adding R functionality, this second edition features three new chapters and several sections on new topics that are extremely relevant to the current research in statistical methodology. Revised or expanded topics include linear fixed, random and mixed effects models, generalized linear models, Bayesian and hierarchical linear models, model selection, multiple comparisons, and regularized and robust regression. New to the Second Edition: Coverage of inference for linear models has been expanded into two chapters. Expanded coverage of multiple comparisons, random and mixed effects models, model selection, and missing data. A new chapter on generalized linear models (Chapter 12). A new section on multivariate linear models in Chapter 13, and expanded coverage of the Bayesian linear models and longitudinal models. A new section on regularized regression in Chapter 14. Detailed data illustrations using R. The authors' fresh approach, methodical presentation, wealth of examples, use of R, and introduction to topics beyond the classical theory set this book apart from other texts on linear models. It forms a refreshing and invaluable first step in students' study of advanced linear models, generalized linear models, nonlinear models, and dynamic models.

It highlights the synthesis, classification, biological function, medicinal applications, and an overview of the recent advancements for the enhanced production of novel secondary metabolites in plants. It overviewed the role of induced mutation, salinity stress, Brassinosteroids impact to increase the secondary metabolic contents in plants and suggests increase in enzymatic activity in plants could be due to various point mutations which in turn could play a role at transcriptome levels. It discussed the significant role of endophytes to enhance the contents of plant secondary metabolites. Alternatively, it also suggests urgent need to set up the standard operating procedures using hydroponics system of cultivation for significant enhancement of secondary metabolite contents. It enlists various in vitro techniques to enhance plant secondary metabolites contents using plant tissue culture approaches. It systematically overviewed the state of art in biotechnological tools viz. CRISPER Cas9, and RNAi to enhance the plant secondary metabolite contents and recommend CRISPER Cas9 technology over the RNAi, ZFNs and TALENs because of its relatively simple and high precision method with easily programmable tool by changing the guide sequence of the sgRNA to any DNA sequence of interest with its capacity to recognize multiple targeted genes with very low off-target effects due to reduced CpG methylation.

Animal Welfare An Accessible Overview of the Concept of Sentience Throughout the Animal Kingdom and Why It Matters to Humans Animal Welfare explores the concept of sentience and the development of sentient minds throughout the animal kingdom. The work provides improved definitions and analysis of the ideas of sentience, cognition, and consciousness, along with evidence of advanced mental formulation in birds, fish, and invertebrates. Considerations between humans and animals are also discussed, such as outcome-based ethics in relation to humans' duties of care and the rights and wrongs of domestication. The work is divided into three parts and covers key topics such as: Specifics of animal sentience, from pain and suffering, to fear and dread, all the way to animals' social life and the comfort/joy/hope/despair they experience What we know about the sentience of different classes of animals in the waters, air, savannah/plains, and forests Considerations on human interactions based on animal sentience, including death (killing), animal farms, animals in laboratories, wild animals in captivity, and animals in sports and entertainment Analysis on what humans can learn from animals based on what we know about their varying levels of sentience Animal Welfare serves as an invaluable analysis of animal sentience for students, teachers, and professionals directly involved in the study, teaching, and applications of animal behavior, motivation, and welfare. Thanks to the wide-ranging implications of animal sentience, the work will also appeal to everyone with a broader interest in animal behavior and human/animal interactions.

A natural history of cheating from selfish genes to lying politicians Nature is rife with cheating. Possums play possum, feigning death to cheat predators. Crows cry wolf to scare off rivals. Amphibians and reptiles are inveterate impostors. Even genes and cells cheat. The Liars of Nature and the Nature of Liars explores the evolution of cheating in the natural world, revealing how dishonesty has given rise to wondrous diversity. Blending cutting-edge science with a wealth of illuminating examples—from microscopic organisms to highly intelligent birds and mammals—Lixing Sun shows how cheating in nature relies on two basic rules. One is lying, by which cheaters exploit honest messages in communication signals and use them to serve their own interests. The other is deceiving, by which cheaters exploit the biases and loopholes in the sensory systems of other creatures. Sun demonstrates that cheating serves as a potent catalyst in the evolutionary arms race between the cheating and the cheated, resulting in a biological world teeming with complexity and beauty. Brimming with insight and humor, The Liars of Nature and the Nature of Liars also looks at the prevalence of cheating in human society, identifying the kinds of cheating that spur innovation and cultural vitality and laying down a blueprint for combatting malicious cheating such as fake news and disinformation.

This book provides insight into the world of pharmaceutical quality systems and the key elements that must be in place to change the business and organizational dynamics from task-oriented procedure-based cultures to truly integrated quality business systems that are self-detecting and correcting. Chapter flow has been changed to adopt a quality systems organization approach, and supporting chapters have been updated based on current hot topics including the impact of the worldwide supply chain complexity and current regulatory trends. Key Features: Presents insight into the world of pharmaceutical quality systems Analyzes regulatory trends and expectations Includes approaches and practices used in the industry to comply with regulatory requirements Discusses recent worldwide supply chain issues Delivers valuable information to a worldwide audience regarding the current GMP practices in the industry

An introductory but detailed treatise which includes some 1,000 references and solved examples and end-of-chapter problems, making it useful to both students and practitioners. The pharmokinetics, pharmacodynamics, and biological and biopharmaceutical parameters pertinent to each route of administra

Dismissed by some as the last of the anti-Darwinians, his fame as a rigorous biologist even tainted by an alleged link to National Socialist ideology, it is undeniable that Jakob von Uexkull (1864-1944) was eagerly read by many philosophers across the spectrum of philosophical schools, from Scheler to Merleau-Ponty and Deleuze and from Heidegger to Blumenberg and Agamben. What has then allowed his name to survive the misery of history as well as the usually fatal gap between science and humanities? This collection of essays attempts for the first time to do justice to Uexkull's theoretical impact on Western culture. By highlighting his importance for philosophy, the book aims to contribute to the general interpretation of the relationship between biology and philosophy in the last century and explore the often neglected connection between continental philosophy and the sciences of life. Thanks to the exploration of Uexkull's conceptual legacy, the origins of cybernetics, the overcoming of metaphysical dualisms, and a refined understanding of organisms appear variedly interconnected. Uexkull's background and his relevance in current debates are thoroughly examined as to appeal to undergraduate and postgraduate students, as well as postdoctoral researchers in fields such as history of the life sciences, philosophy of biology, critical animal studies, philosophical anthropology, biosemiotics and biopolitics.

Focused specifically on Life Science Start-Ups Examines how to determine a company valuation and future "fundable milestones" Explores how to align regulatory and clinical strategies Discusses intellectual property derived from a university or individual through formation to exit. Reviews how start-ups must simultaneously meet the needs of multiple constituencies at once: investors, regulators, customers and exit candidates

Focused specifically on Life Science Start-Ups Examines how to determine a company valuation and future "fundable milestones" Explores how to align regulatory and clinical strategies Discusses intellectual property derived from a university or individual through formation to exit. Reviews how start-ups must simultaneously meet the needs of multiple constituencies at once: investors, regulators, customers and exit candidates

Provides a proficient guide on the relationship between AI and healthcare and how AI is changing all aspects of the health care industry Covers how deep learning will help in the diagnosis and the prediction of disease spread Presents a comprehensive review of research applying deep learning in health informatics in the fields of medical imaging, electronic health records, genomics, and sensing Highlights various challenges in applying the deep learning in health care Promotes research in deep learning application in understanding the biomedical process

* Solid research basis, drawing on findings from a 4-year research project with in-depth interviews with judges, attorneys, and seasoned forensic neuropsychologists and psychologists as well as further interviews with professionals in other fields such as engineering, physics and economics. * Provides focused attention on how experts interact with judges, attorneys, and juries * Challenges experts to avoid the traps of professional jargon and traditional manners of presenting information/knowledge/opinions. * Provides a step-by-step approach to orienting the new academic to expert witnessing

* Solid research basis, drawing on findings from a 4-year research project with in-depth interviews with judges, attorneys, and seasoned forensic neuropsychologists and psychologists as well as further interviews with professionals in other fields such as engineering, physics and economics. * Provides focused attention on how experts interact with judges, attorneys, and juries * Challenges experts to avoid the traps of professional jargon and traditional manners of presenting information/knowledge/opinions. * Provides a step-by-step approach to orienting the new academic to expert witnessing

This new volume, Advances in Sorghum Science: Botany, Production, and Crop Improvement, provides an easy-to-read and comprehensive treatment of the sorghum crop. With the world's production of sorghum topping over 55 million tons annually, sorghum is very important for as a staple dietary food for much of the world as a rich source of micronutrients and macronutrients, as an ingredient in the processing of many foods, and as a source of fodder. The authors of the volume provide detailed information on sorghum from several disciplines and bring together recent literature under one umbrella. The book covers the various aspects of the sorghum crop, starting from its origin, to its domestication, and going on to biotechnology of the crop. It describes sorghum production, ideotypes, botany, physiology, abiotic and biotic factors affecting crop productivity, methods of cultivation, postharvest management, grain quality analysis for food processing, improvement of sorghum crop, and research advancements in breeding and biotechnology. This valuable resource will be helpful to researchers and scientists working to understand the relation between various disciplines and the implementation of new methods and technology for crop improvement and higher productivity. The multi-pronged approach will help to enable the increase sorghum productivity to meet the world's growing demands.

In her quest for global leadership in science and technology, the People's Republic of China has attained top ranks in the number of scientific publications, "hot papers," or national and international patent applications. However, analysis of the underlying structures and mechanisms is hindered by the sheer flood of data, stringent government control of all media, and ambiguities inherent in translation from Chinese. This book overcomes these difficulties and provides a concise picture of biotechnology-related research and development in China. It begins with brief accounts of China's geography, people, political and administrational structure, economy, finance, infrastructure related to science and technology, and educational system. It presents succinct accounts on structures and developments in biomedicine, diagnostics, agriculture, fermented food, bioindustry, and environmental biotechnology, with reference to government, industry, and academia. Finally, it predicts the next steps in Chinese biotechnology for the national agenda and, in view of China's ambitious global development strategy, the Belt and Road Initiative.

Reinforces basic principles of digital forensic science with examples of current trends and future prospects Broadens the readers understanding of digital forensic investigations and information security techniques using crime science Shares many tips and insights into unexplored areas of digital forensics and information security from scholars, practitioners and policy makers. Provides a level of language that suits all audiences across the globe Supplies opportunities to practice techniques which demonstrate how crime science can be used to enrich digital forensics and information security