+ Clearly exposes the most frequent calumnies made against science + Shows how dogmatic religion, the financial interests of certain industries, and opportunistic politicians sometime work in cohort to undermine the public’s trust in science + Acknowledges that science’s most mistaken critics are often skilled communicators, and that effectively defending science requires an equally skilled defense + Shows that while the “Science Wars“ of the 1990s have abated, their effects on some of the methodologies in higher education and the larger population continue + Examines three case studies to clearly illustrate how reliable scientific knowledge is secured: • Eratosthenes’ discovery of the circumference of the earth • Louis Pasteur’s development of anthrax and rabies vaccines • The rapid emergence of scientific consensus regarding continental drift

Protein Homeostasis in Drug Discovery Comprehensive resource on all aspects of protein homeostasis, covering both historical perspectives and emerging technologies that are revolutionizing the field Protein Homeostasis in Drug Discovery highlights drug discovery and development efforts targeting protein homeostasis and considers the emerging appreciation that a protein's activity may not be the only factor to consider when developing therapeutic agents. The chapters cover various aspects of protein homeostasis such as cellular localization, abundance, interactions, and more. Moreover, the text contains up-to-date information regarding targeted protein degradation, an emerging drug discovery modality. Readers interested in targeting different regulatory events that control protein homeostasis or modulating protein abundance will find this book an excellent resource. Furthermore, those interested in the link between biological function and regulating protein levels in living organisms, especially in the context of drug discovery, will learn from numerous examples discussed in this book. In Protein Homeostasis in Drug Discovery, readers can expect to find information on: Protein folding, quality control, pharmacology, and drug targeting processes Recent advances in our understanding of protein homeostasis, covering emerging technologies and opportunities for therapeutic intervention Targeted protein degradation (TPD) and strategies such as PROTACs and molecular glues, including a chapter on TPD as an antiviral drug discovery strategy Drug discovery and development efforts aimed at correcting, stabilizing, and rescuing proteins, with examples included Advantages and key shortcomings of both phenotypic and target-based traditional drug discovery methods Collectively, Protein Homeostasis in Drug Discovery offers the reader an opportunity to learn more about the importance of considering and targeting protein homeostasis. The text is a must-read resource for academics, professionals in the pharmaceutical industry, and advanced students in various science-related fields.

Science used to be experiments and theory, now it is experiments, theory and computations. The computational approach to understanding nature and technology is currently flowering in many fields such as physics, geophysics, astrophysics, chemistry, biology, and most engineering disciplines. This book is a gentle introduction to such computational methods where the techniques are explained through examples. It is our goal to teach principles and ideas that carry over from field to field. You will learn basic methods and how to implement them. In order to gain the most from this text, you will need prior knowledge of calculus, basic linear algebra and elementary programming.

During the last twenty years, Kanta (TM)s theoryof biology increasinglyattracted the attention of scholars and has developed into a fieldwhich is itself growing rapidly in importance within Kant studies. Thevolume Kanta (TM)s Theory of Biology presents 15 interpretative essayswritten by important philosophers working in the field, coveringtopics from seventeenth- and eighteenth-century biological theories, the development of the philosophy of biology in Kanta (TM)s writings, theteleology of nature in Kanta (TM)s Critique of the Power of Judgment, andcurrent perspectives on the teleology of nature. Extensive collected volume Highly debated field of philosophy 15 authoritative authors Historical in-depth studieson topical subjects

The introduction of low temperature plasma technology to medical research and to the healthcare arena in general is set to revolutionise the way we cure diseases. This innovative medium offers a valid and advantageous replacement of traditional chemical-based medications. Its application in the inactivation of pathogens in particular, avoids the recurrent problem of drug resistant microorganisms. This is the first book dedicated exclusively to the emerging interdisciplinary field of plasma medicine. The opening chapters discuss plasmas and plasma chemistry, the fundamentals of non-equilibrium plasmas and cell biology. The rest of the book is dedicated to current applications, illustrating a plasma-based approach to wound healing, electrosurgery, cancer treatment and even dentistry. The text provides a clear and integrated introduction to plasma technology and has been devised to answer the needs of researchers from different communities. It will appeal to graduate students and physicists, engineers, biologists, medical doctors and biochemists.

"Cryogenic Freezing Manual" is an aid to anyone in the process of using Liquid Nitrogen (LN2) to freeze a product and to anyone currently using LN2 freezing equipment.

Leading researchers discuss the past and present of chromatography

More than one hundred years after Mikhail Tswett pioneered adsorption chromatography, his separation technique has developed into an important branch of scientific study. Providing a full portrait of the discipline, "Chromatography: A Science of Discovery" bridges the gap between early, twentieth-century chromatography and the cutting edge of today's research.

Featuring contributions from more than fifty award-winning chromatographers, "Chromatography" offers a multifaceted look at the development and maturation of this field into its current state, as well as its importance across various scientific endeavors. The coverage includes:

Consideration of chromatography as a unified science rather than just a separation method

Key breakthroughs, revolutions, and paradigm shifts in chromatography

Profiles of Nobel laureates who used chromatography in their research, and the role it played

Recent advances in column technology

Chromatography's contributions to the agricultural, space, biological/medical sciences; pharmaceutical science; and environmental, natural products, and chemical analysis

Future trends in chromatography

With numerous references and an engaging series of voices, "Chromatography: A Science of Discovery" offers a diverse look at an essential area of science. It is a unique and invaluable resource for researchers, students, and other interested readers who seek a broader understanding of this field.

Statistical reasoning and modeling are of critical importance to modern biology. This textbook introduces fundamental concepts from probability and statistics which will pave the way for the student of biology to become a well-rounded scientist. No previous study of probability or statistics is assumed. Calculus topics are not used extensively in this book, though some integration and differentiation are expected. The calculus prerequisite is primarily intended to assure a certain level of mathematical maturity. This book puts emphasis on examples, which are presented to motivate the theory. The presentation style is concise and self-contained, briefly including the mathematical elements that are needed for studying probability and statistics. The examples are relevant to students in the life sciences with interests in genetics, biology, ecology, health, etc. We believe that aspects of probability theory are of biological interest and that probability underlies the theory of inferential statistics. Thus, we place an equal emphasis on probability and statistics which are both essential for solving and understanding many types of biological problems.

This book presents the fundamental physics of optical interferometry as applied to biophysical, biological and medical research. Interference is at the core of many types of optical detection and is a powerful probe of cellular and tissue structure in interfererence microscopy and in optical coherence tomography. It is also the root cause of speckle and other imaging artefacts that limit range and resolution. For biosensor applications, the inherent sensitivity of interferometry enables ultrasensitive detection of molecules in biological samples for medical diagnostics. In this book, emphasis is placed on the physics of light scattering, beginning with the molecular origins of refraction as light propagates through matter, and then treating the stochastic nature of random fields that ultimately dominate optical imaging in cells and tissue. The physics of partial coherence plays a central role in the text, with a focus on coherence detection techniques that allow information to be selectively detected out of incoherent and heterogeneous backgrounds. Optical Interferometry for Biology and Medicine is divided into four sections. The first covers fundamental principles, and the next three move up successive scales, beginning with molecular interferometry (biosensors), moving to cellular interferometry (microscopy), and ending with tissue interferometry (biomedical). An outstanding feature of the book is the clear presentation of the physics, with easy derivations of the appropriate equations, while emphasizing "rules of thumb" that can be applied by experimental researchers to give semi-quantitative predictions.

Significant advances have been made in the field since the previous classic texts were written. This text brings the available knowledge up to date.
* Enables the reader to use a wide variety of nonlinear system identification techniques.
* Offers a thorough treatment of the underlying theory.
* Provides a MATLAB toolbox containing implementation of the latest identification methods together with an extensive set of problems using realistic data sets.

This book (hardcover) is part of the TREDITION CLASSICS. It contains classical literature works from over two thousand years. Most of these titles have been out of print and off the bookstore shelves for decades. The book series is intended to preserve the cultural legacy and to promote the timeless works of classical literature. Readers of a TREDITION CLASSICS book support the mission to save many of the amazing works of world literature from oblivion. With this series, tredition intends to make thousands of international literature classics available in printed format again - worldwide.

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