This text is devoted to the rapidly evolving microsystem technology that promises to unravel a wide range of academic and industrial analytical problems, such as trace proofing and single molecule detection, substance selection, miniturized sequencing of biopolymers, handling of single molecules or cells in micro devices and the optimization of molecular functions. All these applications will have a bearing on the future work in the diagnosis of disease, high-throughput screening approaches and combinatorial chemistry. These should be of importance in all life science fields where high efficiency, budgetary restrictions, high sensitivity, the presence of small amounts of highly toxic waste products and storage space constraints are relevant parameters. Taken as a whole this text seeks to reveal how microsystems technology is how changing the face of biology, forensics, gene therapy, molecular medicine, screening, and more.

This book offers an integrated historical and philosophical examination of the origin of genetics. The author contends that an integrated HPS analysis helps us to have a better understanding of the history of genetics, and sheds light on some general issues in the philosophy of science. This book consists of three parts. It begins with historical problems, revisiting the significance of the work of Mendel, de Vries, and Weldon. Then it turns to integrated HPS problems, developing an exemplar-based analysis of the development and the progress in early genetics. Finally, it discusses philosophical problems: conceptual change, evidence, and theory choice. Part I lays out a new historiography, serving as a basis for the discussions in part II and part III. Part II introduces a new integrated HPS method to analyse and interpret the historiography in Part I and to re-examine the philosophical issues in Part III. Part III develops new philosophical accounts which will in turn make a better sense of the history of scientific practice more generally. This book provides a practical defence of integrated HPS: the best way to defend integrated HPS is to do it.

This workbook offers ten investigative cases. Each case study requires students to synthesize information from multiple chapters of the text and apply that knowledge to a real-world scenario as they pose hypotheses, gather NEW! information, analyze evidence, graph data, and draw conclusions. A link to a student website is in the Study Area in MasteringBiology.

Human civilization has evolved to the point at which we can consider tapping space resources and expanding beyond Earth's atmosphere. The Introduction surveys possible motivations for large-scale human emigration to space. Since our early ancestors began to move out of Africa, humans have constantly expanded their range. Today, the pattern of human settlement extends from pole to pole. Humans regularly visit the upper troposphere and ocean floor and technology has enabled a few to even reside above the atmosphere in space stations.

For the next few millennia at least (barring breakthroughs), the human frontier will include the solar system and the nearest stars. Will it better to settle the Moon, Mars, or a nearby asteroid and what environments can we expect to find in the vicinity of nearby stars are questions that need to be answered if mankind is to migrate into space.

Collaborative research in bioinformatics and systems biology is a key element of modern biology and health research. This book highlights and provides access to many of the methods, environments, results and resources involved, including integral laboratory data generation and experimentation and clinical activities. Collaborative projects embody a research paradigm that connects many of the top scientists, institutions, their resources and research worldwide, resulting in first-class contributions to bioinformatics and systems biology. Central themes include describing processes and results in collaborative research projects using computational biology and providing a guide for researchers to access them.

The book is also a practical guide on how science is managed. It shows how collaborative researchers are putting results together in a way accessible to the entire biomedical community.

This book provides simultaneously a design blueprint, user guide, research agenda, and communication platform for current and future developments in artificial intelligence (AI) approaches to systems biology. It places an emphasis on the molecular dimension of life phenomena and in one chapter on anatomical and functional modeling of the brain.

As design blueprint, the book is intended for scientists and other professionals tasked with developing and using AI technologies in the context of life sciences research. As a user guide, this volume addresses the requirements of researchers to gain a basic understanding of key AI methodologies for life sciences research. Its emphasis is not on an intricate mathematical treatment of the presented AI methodologies. Instead, it aims at providing the users with a clear understanding and practical know-how of the methods. As a research agenda, the book is intended for computer and life science students, teachers, researchers, and managers who want to understand the state of the art of the presented methodologies and the areas in which gaps in our knowledge demand further research and development. Our aim was to maintain the readability and accessibility of a textbook throughout the chapters, rather than compiling a mere reference manual. The book is also intended as a communication platform seeking to bride the cultural and technological gap among key systems biology disciplines. To support this function, contributors have adopted a terminology and approach that appeal to audiences from different backgrounds.

"Surprising. Impressive. Cannibalism restores my faith in humanity." --Sy Montgomery, The New York Times Book Review For centuries scientists have written off cannibalism as a bizarre phenomenon with little biological significance. Its presence in nature was dismissed as a desperate response to starvation or other life-threatening circumstances, and few spent time studying it. A taboo subject in our culture, the behavior was portrayed mostly through horror movies or tabloids sensationalizing the crimes of real-life flesh-eaters. But the true nature of cannibalism--the role it plays in evolution as well as human history--is even more intriguing (and more normal) than the misconceptions we've come to accept as fact. In Cannibalism: A Perfectly Natural History, zoologist Bill Schutt sets the record straight, debunking common myths and investigating our new understanding of cannibalism's role in biology, anthropology, and history in the most fascinating account yet written on this complex topic. Schutt takes readers from Arizona's Chiricahua Mountains, where he wades through ponds full of tadpoles devouring their siblings, to the Sierra Nevadas, where he joins researchers who are shedding new light on what happened to the Donner Party--the most infamous episode of cannibalism in American history. He even meets with an expert on the preparation and consumption of human placenta (and, yes, it goes well with Chianti). Bringing together the latest cutting-edge science, Schutt answers questions such as why some amphibians consume their mother's skin; why certain insects bite the heads off their partners after sex; why, up until the end of the twentieth century, Europeans regularly ate human body parts as medical curatives; and how cannibalism might be linked to the extinction of the Neanderthals. He takes us into the future as well, investigating whether, as climate change causes famine, disease, and overcrowding, we may see more outbreaks of cannibalism in many more species--including our own. Cannibalism places a perfectly natural occurrence into a vital new context and invites us to explore why it both enthralls and repels us.

This book (hardcover) is part of the TREDITION CLASSICS. It contains classical literature works from over two thousand years. Most of these titles have been out of print and off the bookstore shelves for decades. The book series is intended to preserve the cultural legacy and to promote the timeless works of classical literature. Readers of a TREDITION CLASSICS book support the mission to save many of the amazing works of world literature from oblivion. With this series, tredition intends to make thousands of international literature classics available in printed format again - worldwide.

In general, several mathematical models can be designed in order to describe a biological or medical process and there is no unique criterion which model gives the best description. This book presents several of these models and shows applications of them to different biological and medical problems. The book shows that operations research expertise is necessary in respect to modeling, analysis and optimization of biosystems.

Data mining provides a set of new techniques to integrate, synthesize, and analyze tdata, uncovering the hidden patterns that exist within. Traditionally, techniques such as kernel learning methods, pattern recognition, and data mining, have been the domain of researchers in areas such as artificial intelligence, but leveraging these tools, techniques, and concepts against your data asset to identify problems early, understand interactions that exist and highlight previously unrealized relationships through the combination of these different disciplines can provide significant value for the investigator and her organization.

A "beautifully written" (Kirkus Reviews, starred review) memoir-manifesto from the first female director of the National Science Foundation about the entrenched sexism in science, the elaborate detours women have take to bypass the problem, and how to fix the system. If you think sexism thrives only on Wall Street or Hollywood, you haven't visited a lab, a science department, a research foundation, or a biotech firm. Rita Colwell is one of the top scientists in America: the groundbreaking microbiologist who discovered how cholera survives between epidemics and the former head of the National Science Foundation. But when she first applied for a graduate fellowship in bacteriology, she was told, "We don't waste fellowships on women." A lack of support from some male superiors would lead her to change her area of study six times before completing her PhD. A Lab of One's Own is an "engaging" (Booklist) book that documents all Colwell has seen and heard over her six decades in science, from sexual harassment in the lab to obscure systems blocking women from leading professional organizations or publishing their work. Along the way, she encounters other women pushing back against the status quo, including a group at MIT who revolt when they discover their labs are a fraction of the size of their male colleagues. Resistance gave female scientists special gifts: forced to change specialties so many times, they came to see things in a more interdisciplinary way, which turned out to be key to making new discoveries in the 20th and 21st centuries. Colwell would also witness the advances that could be made when men and women worked together--often under her direction, such as when she headed a team that helped to uncover the source of anthrax used in the 2001 letter attacks. A Lab of One's Own is "an inspiring read for women embarking on a career or experiencing career challenges" (Library Journal, starred review) that shares the sheer joy a scientist feels when moving toward a breakthrough, and the thrill of uncovering a whole new generation of female pioneers. It is the science book for the #MeToo era, offering an astute diagnosis of how to fix the problem of sexism in science--and a celebration of women pushing back.

This book collects three outstanding examples of the work of Mexican biologist Alfonso Luis Herrera (1868-1943), a pioneer in experimental origins of life research. Two of the collected works appear here in English for the first time. Herrera's works represent the attempt to deal experimentally with the issue of an autotrophic origin of life, a possibility that was widely accepted prior to Alexander I. Oparin's ideas regarding the possibility of organic synthesis and the origin of life in an early Earth environment. An active promoter of Darwinian ideas in Latin America, Herrera was also among the first 20th century researchers to attempt to "create life in a test tube." This collection shows the remarkable prescience of researchers in Mexico with regards to laboratory approaches to the problem of the origin of life. It also includes a modern commentary by researchers actively engaged in research in prebiotic evolution and the origins of life, and deeply concerned with the historical development of ideas in these fields. The list includes H. James Cleaves, Antonio Lazcano, Alicia Negron-Gonzalez and Juli Pereto, who discuss in detail the relevance of Herrera's ideas to modern theory and their historical context. The book will expose modern readers and researchers to currents of thinking that have been lost, largely to time and language inaccessibility, of a seminal early theoretical biologist.

In June 1975, the distinguished Harvard entomologist Edward O. Wilson published a truly huge book entitled, Sociobiology: The New Synthesis. In this book, drawing on both fact and theory, Wilson tried to present a com prehensive overview of the rapidly growing subject of 'sociobiology', the study of the biological nature and foundations of animal behaviour, more precisely animal social behaviour. Although, as the title rather implies, Wilson was more surveying and synthesising than developing new material, he com pensated by giving the most thorough and inclusive treatment possible, beginning in the animal world with the most simple of forms, and progressing via insects, lower invertebrates, mammals and primates, right up to and in cluding our own species, Homo sapiens. Initial reaction to the book was very favourable, but before the year was out it came under withering attack from a group of radical scientists in the Boston area, who styled themselves 'The Science for the People Sociobiology Study Group'. Criticism, of course, is what every academic gets (and needs ); but, for two reasons, this attack was particularly unpleasant. First, not only were Wilson's ideas attacked, but he himself was smeared by being linked with the most reactionary of political thinkers, including the Nazis."

N.M. V AN STRAALEN** and D.A. KRIVOLUTSKY* **Department of Ecology and Ecotoxicology VrUe Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands *Institute of Evolutionary Animal Morphology and Ecology Russian Academy of Sciences, Leninsky Prospekt 33 117071 Moscow, Russian Federation Many industrialized and developing countries are faced with the assessment of potential risks associated with contaminated land. A variety of human activities, including municipal waste disposal, industrial emissions, military testing, and agricultural practices have left their impacts on soils in the form of elevated, and locally high concentrations of toxicants. In several cases sources have not yet been stopped and contamination continues. Decisions on the management of contaminated sites require information on the extent to which toxicants adversely affect the soil ecosystem. For this purpose, it is often insufficient to extrapolate from abiotic sampling. The detection of a toxicant in the abiotic environment usually does not allow a very strong conclusion on the potential hazards.

Exam Board: WJEC, Eduqas Level: A-level Subject: Biology First Teaching: September 2015 First Exam: Summer 2017 Reinforce students' understanding throughout their course with clear topic summaries and sample questions and answers to help your students target higher grades. Written by experienced teacher Andy Clarke, our Student Guides are divided into two key sections, content guidance and sample questions and answers. Content guidance will: - Develop students' understanding of key concepts and terminology; this guide covers WJEC A-level Unit 3; Eduqas A-level Component 1 and Component 3. - Consolidate students' knowledge with 'knowledge check questions' at the end of each topic and answers in the back of the book. Sample questions and answers will: - Build students' understanding of the different question types, so they can approach each question with confidence. - Enable students to target top grades with sample answers and commentary explaining exactly why marks have been awarded.