Biology in Physics is a radical new book which bridges the gap between biology and physics. The aim is to promote an interdisciplinary exchange of scientific information and ideas, in order to stimulate cooperation in research. The scope of this volume explores both the concepts and techniques of biophysics and illustrates the latest advances in our understanding of many of the specific mechanisms that are used by living organisms. This volume represents a special effort to bring together the information that would allow a nonbiologically oriented physicist to appreciate the important role that physics plays in life sciences.
Key Features
* An introduction to biophysics for non-specialist
* Covers all the important topices in modern biophysics
* Takes account of the latest information emerging from biophysical projects
* Reports on novel therapeutic strategies
* Presents an advanced-level overview of mechanisms that regulate a variety of processes in organisms ranging from bacterial to whales

Medical Risk Prediction Models: With Ties to Machine Learning is a hands-on book for clinicians, epidemiologists, and professional statisticians who need to make or evaluate a statistical prediction model based on data. The subject of the book is the patient's individualized probability of a medical event within a given time horizon. Gerds and Kattan describe the mathematical details of making and evaluating a statistical prediction model in a highly pedagogical manner while avoiding mathematical notation. Read this book when you are in doubt about whether a Cox regression model predicts better than a random survival forest. Features: All you need to know to correctly make an online risk calculator from scratch Discrimination, calibration, and predictive performance with censored data and competing risks R-code and illustrative examples Interpretation of prediction performance via benchmarks Comparison and combination of rival modeling strategies via cross-validation Thomas A. Gerds is a professor at the Biostatistics Unit at the University of Copenhagen and is affiliated with the Danish Heart Foundation. He is the author of several R-packages on CRAN and has taught statistics courses to non-statisticians for many years. Michael W. Kattan is a highly cited author and Chair of the Department of Quantitative Health Sciences at Cleveland Clinic. He is a Fellow of the American Statistical Association and has received two awards from the Society for Medical Decision Making: the Eugene L. Saenger Award for Distinguished Service, and the John M. Eisenberg Award for Practical Application of Medical Decision-Making Research.

This book, written by an international team of experts, introduces the reader to various aspects of complexity theory and its applications. It illustrates the latest trends in science to go beyond the mechanistic Newtonian view of the world by shifting the focus to self-organization, adaptation, and emergent phenomena. The authors discuss these properties of complex systems in biology, ecology and chemistry along with the structure and interconnectedness of the "layers" of complexity. The qualitative description is complemented by a discussion of methods for complexity quantification. Networks are covered in detail as a universal language of the complex world.

General readers, as well as undergraduate and graduate students and researchers in life sciences, chemistry, and nanotechnology will find this book to be of great interest.

This NATO Advanced Study Institute (co-sponsored by FEBS and INTAS) under the title "Chemical Probes in Biology" was designed to summarize and disseminate recent expert knowledge regarding a deeper understanding ofbiological phenomena on a molecular level. Such scientific activities -frequently termed Bio-organic Chemistry or Chemical Biology are constituting a highly interdisciplinary branch of chemistry beyond the traditional ways in which chemists and biologists have been working in the past. Thus, on this occasion we were bringing together senior experts from the disciplines of Chemistry and Biology in order to amalgamate their diverse yet basically common interests in this area. Ultimate goal was - next to an exchange of information between the two scientific cultures - the communication ofexciting possibilities in interdisciplinary research to the young scientists present. The meeting was held in the Anargyros and Korgialenios School on the Island ofSpeteses, Greece from 18-30 August 2002. The ASI was attended by a total of 91 scholars from 23 different countries. A group of 27 speakers presented a series of 34 highly stimulating, informative and educational lectures covering a broad range of topics relevant to the general theme ofthis meeting: Science at the InteifaceofChemistry, Biology and Medicine. The lectures were complemented by a total of 89 posters presented by the young scholars and a series of short lectures derived thereof This was clearly one ofthe highlites of the meeting creating a lively atmosphere of interaction and intellectual creativity - typical phenomena for the whole meeting."

This book presents methodological and application research in detecting cellular and molecular biophysical properties based on atomic force microscopy (AFM) nanorobotics. Series methods for in situ label-free visualizing and quantifying the multiple physical properties of single cells and single molecules were developed, including immobilization strategies for observing fine structures of living cells, measurements of single-cell mechanics, force recognition of molecular interactions, and mapping protein organizations on cell surface. The biomedical applications of these methods in clinical lymphoma treatments were explored in detail, including primary sample preparation, cancer cell recognition, AFM detection and data analysis. Future directions about the biomedical applications of AFM are also given.

Investigating Biological Systems Using Modeling describes how to apply software to analyze and interpret data from biological systems. It is written for students and investigators in lay person's terms, and will be a useful reference book and textbook on mathematical modeling in the design and interpretation of kinetic studies of biological systems. It describes the mathematical techniques of modeling and kinetic theory, and focuses on practical examples of analyzing data. The book also uses examples from the fields of physiology, biochemistry, nutrition, agriculture, pharmacology, and medicine.
Key Features:
* Contains practical descriptions of how to analyze kinetic data
* Provides examples of how to develop and use models
* Describes several software packages including SAAM/CONSAM
* Includes software with working models

This book offers an overview of some recent advances in the Computational Bioacoustics methods and technology. In the focus of discussion is the pursuit of scalability, which would facilitate real-world applications of different scope and purpose, such as wildlife monitoring, biodiversity assessment, pest population control, and monitoring the spread of disease transmitting mosquitoes. The various tasks of Computational Bioacoustics are described and a wide range of audio parameterization and recognition tasks related to the automated recognition of species and sound events is discussed. Many of the Computational Bioacoustics methods were originally developed for the needs of speech, audio, or image processing, and afterwards were adapted to the requirements of automated acoustic recognition of species, or were elaborated further to address the challenges of real-world operation in 24/7 mode. The interested reader is encouraged to follow the numerous references and links to web resources for further information and insights. This book is addressed to Software Engineers, IT experts, Computer Science researchers, Bioacousticians, and other practitioners concerned with the creation of new tools and services, aimed at enhancing the technological support to Computational Bioacoustics applications. STTM, Speech Technology and Text Mining in Medicine and Health Care This series demonstrates how the latest advances in speech technology and text mining positively affect patient healthcare and, in a much broader sense, public health at large. New developments in text mining methods have allowed health care providers to monitor a large population of patients at any time and from any location. Employing advanced summarization techniques, patient data can be readily extracted from extensive clinical documents in electronic health records and immediately made available to the physician. These same summarization techniques can also aid the healthcare provider in extracting from the large corpora of medical literature the relevant information for treating the patient. The series topics include the design and acceptance of speech-enabled robots that assist in the operating room, studies of signal processing and acoustic modeling for speech and communication disorders, advanced statistical speech enhancement methods for creating synthetic voice, and technologies for addressing speech and language impairments. Titles in the Series consist of both authored books and edited contributions. All authored books and contributed works are peer-reviewed. The Series is for speech scientists and speech engineers, machine learning experts, biomedical engineers, medical speech pathologists, linguists, and healthcare professionals

Jim Green 1.1 THE THAMES ESTUARY: A PERSONAL VIEW For almost 50 years I have lived close to the Thames estuary (Figure 1.1). In the early 1950s, from our flat in Pimlico, we could walk along the embankment opposite Battersea Power Station. At low tide, the exposed mud had large red patches caused by the haemoglobin in innumerable tubificid worms. These formed the basis of a minor trade. Men with waders and sieves would collect the worms and sell them to the aquarium trade as food for fishes.The superabundance of these worms depended on the gross organic pollution of this reach of the Thames. Towards the end of the 1950s we moved to Teddington, within a few minutes' walk from the lock. Casual observation of the birds on the river indicates an increase in the piscivores over the last 20 years.Cormorants tPhalacrocorax carbo) are regularly seen, and grey herons (Ardea cinerea) are more abundant. On a good day it is possible to see up to eight herons around the weir and below the lock. Another bird that is now common place in the area is the great-crested grebe (Podiceps cristatus).The regular mallard (Anas platyrhynchos)and Canada geese (Branta canadensis)are some times joined by tufted duck (Aythafuligula)and mandarin (Aixgalericulata)."

Mapping Biology Knowledge addresses two key topics in the context of biology, promoting meaningful learning and knowledge mapping as a strategy for achieving this goal. Meaning-making and meaning-building are examined from multiple perspectives throughout the book. In many biology courses, students become so mired in detail that they fail to grasp the big picture. Various strategies are proposed for helping instructors focus on the big picture, using the need to know' principle to decide the level of detail students must have in a given situation. The metacognitive tools described here serve as support systems for the mind, creating an arena in which learners can operate on ideas. They include concept maps, cluster maps, webs, semantic networks, and conceptual graphs. These tools, compared and contrasted in this book, are also useful for building and assessing students' content and cognitive skills. The expanding role of computers in mapping biology knowledge is also explored.

Philosophical understandings of Nature and Human Nature. Classical Greek and modern West, Christian, Buddhist, Taoist, by 14 authors, including Robert Neville, Stanley Rosen, David Eckel, Livia Kohn, Tienyu Cao, Abner Shimoney, Alfred Tauber, Krzysztof Michalski, Lawrence Cahoone, Stephen Scully, Alan Olson and Alfred Ferrarin. Dedicated to the phenomenological ecology of Erazim Koh k, with 10 of his essays and a full bibliography. Overall theme: on the question of the moral sense of nature.

This volume investigates mediated lives and media narratives during the COVID-19 pandemic, with Asia as a focus point. It shows how the pandemic has created an unprecedented situation in this globalized world marked by many disruptions in the social, economic, political and cultural lives of individuals and communities - creating a 'new normal'. It explores the different media vocabularies of fear, panic, social distancing, and contagion from across Asian nations. It focuses on the role media played as most nations faced lockdowns and unique challenges during this crisis. From healthcare workers to sex workers, from racism to nationalism, from the plight of migrant workers in news reporting to state propaganda, this book brings critical questions confronting media professionals into focus. The volume will be of critical interest to scholars and researchers of media and communication studies, politics, especially political communication, social and public policy, and Asian studies.

A cutting-edge survey of formal methods directed specifically at dealing with the deep mathematical problems engendered by the study of developing systems, in particular dealing with developing phase spaces, changing components, structures and functionalities, and the problem of emergence. Several papers deal with the modelling of particular experimental situations in population biology, economics and plant and muscle developments in addition to purely theoretical approaches. Novel approaches include differential inclusions and viability theory, growth tensors, archetypal dynamics, ensembles with variable structures, and complex system models. The papers represent the work of theoreticians and experimental biologists, psychologists and economists. The areas covered embrace complex systems, the development of artificial life, mathematics, computer science, biology and psychology.

This is a collection of some works of Polish philosophers and physicists on philosophical problems of time and spacetime. Without restricting the thematic scope of the papers, the issue conceming objectivity of time flow runs as a uniting thread through most of them. Partly it is discussed directIy, and partly the authors focus on themes which are of paramount importance for one's attitude to that question. In the first six papers the authors deal with their topics against the background of contemporary physics, its theories, its difficulties and discussed conjectures. For the paper of S. Snihur that background is provided by everyday worId-outlook, and the author discusses the problem of existence and character of the future in the light of basic principles of cIassical logic. The paper of A. P61tawski, about the views of the outstanding polish philosopher Roman Ingarden, enriches the thematic scope of the coIIection introducing into it some questions from philosophical anthropology and ethics. JERZY GOLOSZ MOTION, SPACE, TIME*. Abstract. The paper discusses the properties of spacetime we study by analyzing the phenomenon of motion. Of special interest are the spacetime symmetries. the spacetime structures and the ontological status of spacetime. These problems are considered on the grounds of the c1assical theories of motion contained in Newtonian physics, special and general theory of relativity. The controversy between an absolute and a relational conception of motion and its ontological implications are also analyzed.

"Surprising. Impressive. Cannibalism restores my faith in humanity." --Sy Montgomery, The New York Times Book Review For centuries scientists have written off cannibalism as a bizarre phenomenon with little biological significance. Its presence in nature was dismissed as a desperate response to starvation or other life-threatening circumstances, and few spent time studying it. A taboo subject in our culture, the behavior was portrayed mostly through horror movies or tabloids sensationalizing the crimes of real-life flesh-eaters. But the true nature of cannibalism--the role it plays in evolution as well as human history--is even more intriguing (and more normal) than the misconceptions we've come to accept as fact. In Cannibalism: A Perfectly Natural History, zoologist Bill Schutt sets the record straight, debunking common myths and investigating our new understanding of cannibalism's role in biology, anthropology, and history in the most fascinating account yet written on this complex topic. Schutt takes readers from Arizona's Chiricahua Mountains, where he wades through ponds full of tadpoles devouring their siblings, to the Sierra Nevadas, where he joins researchers who are shedding new light on what happened to the Donner Party--the most infamous episode of cannibalism in American history. He even meets with an expert on the preparation and consumption of human placenta (and, yes, it goes well with Chianti). Bringing together the latest cutting-edge science, Schutt answers questions such as why some amphibians consume their mother's skin; why certain insects bite the heads off their partners after sex; why, up until the end of the twentieth century, Europeans regularly ate human body parts as medical curatives; and how cannibalism might be linked to the extinction of the Neanderthals. He takes us into the future as well, investigating whether, as climate change causes famine, disease, and overcrowding, we may see more outbreaks of cannibalism in many more species--including our own. Cannibalism places a perfectly natural occurrence into a vital new context and invites us to explore why it both enthralls and repels us.

This book offers an integrated historical and philosophical examination of the origin of genetics. The author contends that an integrated HPS analysis helps us to have a better understanding of the history of genetics, and sheds light on some general issues in the philosophy of science. This book consists of three parts. It begins with historical problems, revisiting the significance of the work of Mendel, de Vries, and Weldon. Then it turns to integrated HPS problems, developing an exemplar-based analysis of the development and the progress in early genetics. Finally, it discusses philosophical problems: conceptual change, evidence, and theory choice. Part I lays out a new historiography, serving as a basis for the discussions in part II and part III. Part II introduces a new integrated HPS method to analyse and interpret the historiography in Part I and to re-examine the philosophical issues in Part III. Part III develops new philosophical accounts which will in turn make a better sense of the history of scientific practice more generally. This book provides a practical defence of integrated HPS: the best way to defend integrated HPS is to do it.

This book treats Modelling of CFD problems, Numerical tools for PDE, and Scientific Computing and Systems of ODE for Epidemiology, topics that are closely related to the scientific activities and interests of Prof. William Fitzgibbon, Prof. Yuri Kuznetsov, and Prof. O. Pironneau, whose outstanding achievements are recognised in this volume. It contains 20 contributions from leading scientists in applied mathematics dealing with partial differential equations and their applications to engineering, ab-initio chemistry and life sciences. It includes the mathematical and numerical contributions to PDE for applications presented at the ECCOMAS thematic conference "Contributions to PDE for Applications" held at Laboratoire Jacques Louis Lions in Paris, France, August 31- September 1, 2015, and at the Department of Mathematics, University of Houston, Texas, USA, February 26-27, 2016. This event brought together specialists from universities and research institutions who are developing or applying numerical PDE or ODE methods with an emphasis on industrial and societal applications. This volume is of interest to researchers and practitioners as well as advanced students or engineers in applied and computational mathematics. All contributions are written at an advanced scientific level with no effort made by the editors to make this volume self-contained. It is assumed that the reader is a specialist already who knows the basis of this field of research and has the capability of understanding and appreciating the latest developments in this field.

Next-generation DNA and RNA sequencing has revolutionized biology and medicine. With sequencing cost continuously dropping and our ability to generate large datasets rising, data analysis becomes more important than ever. Next-Generation Sequencing Data Analysis walks readers through NGS data analysis step-by-step for a wide range of NGS applications. For each NGS application, this book covers topics from experimental design, sample processing, sequencing strategy formulation, to sequencing reads quality control, data preprocessing, reads mapping or assembly, and more advanced stages that are specific to each application. Major applications include: RNA-seq: both bulk and single-cell (separate chapters) Genotyping and variant discovery through whole genome/exome sequencing Clinical sequencing and detection of actionable variants De novo genome assembly ChIP-seq to map protein-DNA interactions Epigenomics through DNA methylation sequencing Metagenome sequencing for microbiome analysis Before detailing the analytic steps for each of these applications, the book presents introductory cellular and molecular biology as a refresher mostly for data scientists, the ins and outs of widely used NGS platforms, and an overview of computing needs for NGS data management and analysis. The book concludes with a chapter on the changing landscape of NGS technologies and data analytics. The second edition of this book builds on the well-received first edition by providing updates to each chapter. Two brand new chapters are added to meet rising data analysis demands on single-cell RNA-seq and clinical sequencing. The increasing use of long-reads sequencing has also been reflected in all NGS applications. This book discusses concepts and principles that underlie each analytic step, along with software tools for implementation. It highlights key features of the tools while omitting tedious details to provide an easy-to-follow guide for practitioners in life sciences, bioinformatics, biostatistics, and data science. Tools introduced in this book are open-source and freely available.

Holism and reductionism are traditionally seen as incompatible views or approaches to nature. Here Looijen argues that they should rather be seen as mutually dependent and hence co-operating research programmes. He sheds some interesting new light on the emergence thesis, its relation to the reduction thesis, and on the role and status of functional explanations in biology. He discusses several examples of reduction in both biology and ecology, showing the mutual dependence of holistic and reductionist research programmes. Ecologists are offered separate chapters, clarifying some major, yet highly and controversial ecological concepts, such as `community', `habitat', and `niche'. The book is the first in-depth study of the philosophy of ecology. Readership: Specialists in the philosophy of science, especially the philosophy of biology, biologists and ecologists interested in the philosophy of their discipline. Also of interest to other scientists concerned with the holism-reductionism issue.

A "beautifully written" (Kirkus Reviews, starred review) memoir-manifesto from the first female director of the National Science Foundation about the entrenched sexism in science, the elaborate detours women have take to bypass the problem, and how to fix the system. If you think sexism thrives only on Wall Street or Hollywood, you haven't visited a lab, a science department, a research foundation, or a biotech firm. Rita Colwell is one of the top scientists in America: the groundbreaking microbiologist who discovered how cholera survives between epidemics and the former head of the National Science Foundation. But when she first applied for a graduate fellowship in bacteriology, she was told, "We don't waste fellowships on women." A lack of support from some male superiors would lead her to change her area of study six times before completing her PhD. A Lab of One's Own is an "engaging" (Booklist) book that documents all Colwell has seen and heard over her six decades in science, from sexual harassment in the lab to obscure systems blocking women from leading professional organizations or publishing their work. Along the way, she encounters other women pushing back against the status quo, including a group at MIT who revolt when they discover their labs are a fraction of the size of their male colleagues. Resistance gave female scientists special gifts: forced to change specialties so many times, they came to see things in a more interdisciplinary way, which turned out to be key to making new discoveries in the 20th and 21st centuries. Colwell would also witness the advances that could be made when men and women worked together--often under her direction, such as when she headed a team that helped to uncover the source of anthrax used in the 2001 letter attacks. A Lab of One's Own is "an inspiring read for women embarking on a career or experiencing career challenges" (Library Journal, starred review) that shares the sheer joy a scientist feels when moving toward a breakthrough, and the thrill of uncovering a whole new generation of female pioneers. It is the science book for the #MeToo era, offering an astute diagnosis of how to fix the problem of sexism in science--and a celebration of women pushing back.

This book provides unique step-by-step guidance to producing a high quality, effective poster for display at a scientific meeting. It aims to give young or inexperienced scientists the extra confidence and encouragement to start contributing poster presentations to scientific meetings, and enthuse experienced poster presenters to continue to improve upon their presentations, and benefit more from the overall experience. Chapters 1-4 are concerned with the purpose of posters: the pros and cons of poster presentations and how to take advantage of the opportunities they present. Chapters 5-9 cover aspects of what to include: how best to present text and data, and the use of colour in the overall format and design of the poster. Chapters 10-11 deal with actual construction: how to produce posters in a variety of styles and formats, as well as general advice on paper characteristics, drawing aids, adhesives, and cutting equipment. Chapters 12-13 are a guide to transporting the poster to the meeting, and presenting it at the poster session, and should take some of the mystique out of creating the right' image to the people that matter. Chapter 14 gives guidance on hosting poster sessions and avoiding the various pitfalls. Chapter 15 provides an opportunity to critically review some examples of posters presented at international scientific meetings. This book provides concise, practical guidance on all aspects of production and presentation of scientific posters. It alerts the poster presenter to the various pitfalls and how best to avoid them, and to the many opportunities that may be capitalised upon.

Water Worlds in the Solar System: In Search of Habitable Environments and Life is a comprehensive reference on the formation, availability, habitability potential, and astrobiological implications of water in the Solar System. The book provides understanding of the importance of water on Earth to elucidate potential water and biosignature sources on other bodies in the Solar System. It covers processes involved in the formation of Earth and its Moon, genesis of water on those bodies, events on early Earth, and other processes that are applicable to celestial bodies in the Solar System, directly correlating data available on water on other bodies to over 15 Earth analogue sites. This book forms a comprehensive overview on water in the Solar System, from formation to biosignature and habitability considerations. It is ideal for academics, researchers and students working in the field of planetary science, extraterrestrial water research and habitability potential.

The book has no illustrations or index. Purchasers are entitled to a free trial membership in the General Books Club where they can select from more than a million books without charge. Subjects: Nature / Insects