Modern computer-intensive statistical methods play a key role in solving many problems across a wide range of scientific disciplines. Like its bestselling predecessors, the fourth edition of Randomization, Bootstrap and Monte Carlo Methods in Biology illustrates a large number of statistical methods with an emphasis on biological applications. The focus is now on the use of randomization, bootstrapping, and Monte Carlo methods in constructing confidence intervals and doing tests of significance. The text provides comprehensive coverage of computer-intensive applications, with data sets available online. Features Presents an overview of computer-intensive statistical methods and applications in biology Covers a wide range of methods including bootstrap, Monte Carlo, ANOVA, regression, and Bayesian methods Makes it easy for biologists, researchers, and students to understand the methods used Provides information about computer programs and packages to implement calculations, particularly using R code Includes a large number of real examples from a range of biological disciplines Written in an accessible style, with minimal coverage of theoretical details, this book provides an excellent introduction to computer-intensive statistical methods for biological researchers. It can be used as a course text for graduate students, as well as a reference for researchers from a range of disciplines. The detailed, worked examples of real applications will enable practitioners to apply the methods to their own biological data.

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Studies in Philosophy

This book presents a general introduction to the measurement of the biological effects of pollution on the marine environment.

Exam Board: SQA Level: Higher Subject: Biology First Teaching: 2014, First Exam: 2015 Masses of practice questions for every topic on the curriculum. Essential extra questions for every topic on the curriculum, to reinforce learning and build exam confidence. It can be used either alongside the N5 Biology Student Book or as a flexible standalone resource - for homework, independent study or exam practice. Included in this book: Questions for every topic on the curriculum, with more of the tricky ones Example answers with workings-out help explain difficult concepts Hints and tips throughout give practical advice about the different kinds of question Answers can be downloaded from www.collins.co.uk/pages/scottish-curriculum-free-resources

Thoroughly revised and updated, including three new chapters on race, sex and human nature Second edition is split into thirteen more manageable chapters (instead of eight long ones in the first edition), matching course syllabi more effectively and making it easier for students and teachers to use the book Covers the essential topics, such as selection, adaptation, modularity, genes and the environment, neuroscience, evolutionary psychology, and free will and determinism Additional textbook features include: chapter summaries, annotated further reading and glossary.

Kweken van bollen in kamer en kas' is the original edition in Dutch of the reference handbook for growing bulbs in a room and greenhouse. Originally published in 1999.

Doubled haploid technology is an important tool for plant breeding. It allows for significant time reduction in the achievement of homozygous breeding lines of value in crop improvement.

This volume provides an excellent overview of haploid induction and the application of doubled haploids. The authors emphasize advances made in the understanding of microspore embryogenesis, but treat also advances in gynogenesis and the manipulation of parthenogenetic haploid development.

The text contains a thorough discussion of the application of haploidy to the improvement of a number of species from various families, including Brassicaceae, Poaceae, and Solanaceae. The various methods applicable to these species are described in detail. Each chapter contains critical evaluation of the scientific literature and an extensive list of references. This volume is ideally suited for plant breeders, geneticists, and plant cell biologists.

The present monograph analyses the FitzHugh-Nagumo (F-N) model Le., the Cauchy problem for some generalized Van der Pol equation depending on three real parameters a, band c. This model, given in (1. 1. 17), governs the initiation of the cardiac impulse. The presence of the three parameters leads to a large variety of dy namics, each of them responsible for a specific functioning of the heart. For physiologists it is highly desirable to have aglobai view of all possible qualitatively distinct responses of the F-N model for all values of the pa rameters. This reduces to the knowledge of the global bifurcation diagram. So far, only a few partial results appeared and they were spread through out the literature. Our work provides a more or less complete theoretical and numerical investigation of the complex phase dynamics and bifurca tions associated with the F-N dynamical system. This study includes the static and dynamic bifurcations generated by the variation of a, band c and the corresponding oscillations, of special interest for applications. It enables one to predict all possible types of initiations of heart beats and the mechanism of transformation of some types of oscillations into others by following the dynamics along transient phase space trajectories. Of course, all these results hold for the F-N model. The global phase space picture enables one to determine the domain of validity of this model."

The main objective of this book is to systematically describe the basic principles of the most widely used techniques for the analysis of physical, structural, and compositional properties of solids with a spatial resolution of approxi mately 1 m or less. Many books and reviews on a wide variety of microanalysis techniques have appeared in recent years, and the purpose of this book is not to replace them. Rather, the motivation for combining the descriptions of various mi croanalysis techniques in one comprehensive volume is the need for a reference source to help identify microanalysis techniques, and their capabilities, for obtaining particular information on solid-state materials. In principle, there are several possible ways to group the various micro analysis techniques. They can be distinguished by the means of excitation, or the emitted species, or whether they are surface or bulk-sensitive techniques, or on the basis of the information obtained. We have chosen to group them according to the means of excitation. Thus, the major parts of the book are: Electron Beam Techniques, Ion Beam Techniques, Photon Beam Techniques, Acoustic Wave Excitation, and Tunneling of Electrons and Scanning Probe Microscopies. We hope that this book will be useful to students (final year undergrad uates and graduates) and researchers, such as physicists, material scientists, electrical engineers, and chemists, working in a wide variety of fields in solid state sciences."

Singularities in Fluids, Plasmas and Optics, which contains the proceedings of a NATO Workshop held in Heraklion, Greece, in July 1992, provides a survey of the state of the art in the analysis and computation of singularities in physical problems drawn from fluid mechanics, plasma physics and nonlinear optics. The singularities include curvature singularities on fluid interfaces, the onset of turbulence in 3-D inviscid flows, focusing singularities for laser beams, and magnetic reconnection. The highlights of the book include the nonlinear Schr dinger equation for describing laser beam focusing, the method of complex variables for the analysis and computation of singularities on fluid interfaces, and studies of singularities for the 3-D Euler equations. The book is suitable for graduate students and researchers in these areas.

Richard Owen (1804-92) was, after Darwin, the most important figure in Victorian natural history. He was, for most of the six decades of his career, Britain's foremost comparative anatomist and vertebrate palaeontologist. Leader of the nineteenth-century museum movement, he founded London's monumental Natural History Museum, wrote and published copiously and won every professional honour. Positioned at the cutting edge of Victorian science, his work attracted enormous general interest, and he himself came to symbolise 'natural history' in the public mind. His company was sought by royalty (Prince Albert), prime ministers (especially Sir Robert Peel), and by contemporary literati such as Charles Dickens. Owen was, however, a controversial figure whose disagreements with colleagues developed into epic power struggles, the most notorious of which were with Darwin and Huxley. As the most renowned opponent of natural selection, Owen was type-cast as a Cuvierian creationist and became the bete noire of the Darwinian evolution debate. In this comprehensive intellectual and scientific biography, Nicolaas Rupke argues that Owen was no simple-minded anti-evolutionist and, moreover, should be freed from the distortion of the evolution dispute that was only a minor part of his work, yet has come to dominate his memory. Using the museum movement as the primary context of explanation, Rupke throws new light on a wide area of Owen's activities. He reveals the central division in Owen's scientific oeuvre between the functionalism of Oxbridge natural theology and the transcendentalism of German nature philosophy. This epistemological duality confused and puzzled his contemporaries as well as laterhistorians. But as Rupke convincingly demonstrates, it was a fundamental extension of the intellectual and political manoeuvering for control of Victorian cultural institutions, and an inextricable part of the rise to public authority of the most articulate proponents of the scientific study of nature.

The intestinal protozoan Giardia was first described over 300 years ago in 1681 by Leeuwenhoek, from his own stools. In his description of Giardia, he noted the size, movement, and morphology of the organism, and associated its presence with the diarrheic nature of his stools and his dietary habits. This truly remarkable account contains the first description of Giardia in morphologic, pathogenic, and epidemiologic terms. Our knowledge of the organisms in the genus Giardia has advanced tremendously in the past two decades. With the advent of new tech nologies, including techniques in electron microscopy, biochemistry, immunochemistry, tissue culture, and physiology, a tidal wave of information has appeared on the organization and function of this parasitic protozoan and its interaction with its host. The purpose of this book is to celebrate the tricentennial discovery of Giardia by Leeuwenhoek by presenting the above-mentioned advances in our knowledge of Giardia and giardiasis. In the first section of this book, the dominant theme is the biology of the organism and the correlation of structure-function relationships."

A new and innovative account of British sociology's intellectual origins that uses previously unknown archival resources to show how the field's forgotten roots in a late nineteenth and early twentieth-century debate about biology can help us understand both its subsequent development and future potential.

Rapid regeneration of city areas has placed the quality of urban design high on public and policy agendas worldwide. This work examines the achievement of quality in the urban environment, in a planning context. Tracing urban design from its roots, the authors draw on both historical and current practices to examine the key physical, political and economic forces at play and the social pressures and impacts brought about by both failures and achievements in urban design. This illustrated critique of towns and cities draws on examples from across Western Europe, South Africa and USA to examine both public and private sector development practices, controls and fiscal policies within a diverse range of localities. The authors indicate the need for a reinstitution of region-provincial approaches, for closer co-ordination bewteen sectors, and revised fiscal policies in planning and development in order to enhance the quality of urban social experience and environments.

This updated book reflects improvements in a variety of techniques used to study the aptamer field. Beginning with a section on selection procedures, the volume continues with methods to characterize aptamers' interaction and structural properties by biophysical approaches, as well as a variety of applications that have been adapted to the aptamer compound class. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Nucleic Acid Aptamers: Selection, Characterization, and Application, Second Edition serves as an ideal guide for researchers aiming to further our understanding of aptamer biology and more.

Carefully delineating each step in the formation of the lung, Lung Growth and Development examines prenatal and postnatal lung development...the regulation of surfactant protein gene expression and models for the analysis of epithelial gene transcription and function...cellular differentiation and the role of mesenchymal cells...airway gland growth and differentiation...growth regulation in the tracheobronchial epithelium and mucociliary differentiation...embryonic precursors of the pulmonary nervous system and the development of lung innervation...Clara cells, airway smooth muscle development, cell interactions in vessel formation, and the surfactant system...respiratory distress syndrome, bronchopulmonary dysplasia, and compensatory lung growth...and more. Written by over 30 international experts, Lung Growth and Development is a practical guide for pulmonologists and pulmonary disease specialists, physiologists, molecular and cellular biologists, pathologists, neonatalogists and pediatricians, anatomists, pathologists, and graduate-level and medical school students in these disciplines.

Knowledge of the three-dimensional structure of a protein is absolutely required for the complete understanding of its function. The spatial orientation of amino acids in the active site of an enzyme demonstrates how substrate specificity is defined, and assists the medicinal chemist in the design of s- cific, tight-binding inhibitors. The shape and contour of a protein surface hints at its interaction with other proteins and with its environment. Structural ana- sis of multiprotein complexes helps to define the role and interaction of each individual component, and can predict the consequences of protein mutation or conditions that promote dissociation and rearrangement of the complex. Determining the three-dimensional structure of a protein requires milligram quantities of pure material. Such quantities are required to refine crystallization conditions for X-ray analysis, or to overcome the sensitivity limitations of NMR spectroscopy. Historically, structural determination of proteins was limited to those expressed naturally in large amounts, or derived from a tissue or cell source inexpensive enough to warrant the use of large quantities of cells. H- ever, with the advent of the techniques of modern gene expression, many p- teins that are constitutively expressed in minute amounts can become accessible to large-scale purification and structural analysis.

Exam Board: Edexcel Level: A level Subject: Science / Biology First teaching: September 2015 First exams: June 2017 Revise smart and save! Designed for hassle-free classroom and independent study, our Revision Guides are designed to complement the Student Books with a range of specially designed features such as: One-topic-per-page format Worked examples with exemplar answers 'Now Try This' practice questions Knowledge checks and skills checks Includes FREE online edition! With a one-to-one page correspondence between this Revision Guide and the companion Edexcel AS/A level Biology Revision Workbook, the hugely popular REVISE series offers the best value available for A level students.