New York City has the largest medical examiner's office in the United States, and the Brooklyn division is the busiest of the five boroughs. Charles A. Catanese received his Forensic Pathology fellowship training in New York, and then worked full time as a Medical Examiner in the Brooklyn office for more than 10 years. He has personally performed more than 4000 autopsies, including over 400 homicides. Dr. Catanese has worked through several disasters, including TWA Flight 800, AA Flight 587, and more than nine months on the World Trade Center fatalities. He is currently the Chief Medical Examiner of Orange County, New York. Drawing on his wealth of knowledge and experience in solving some of the most difficult cases a forensic examiner could encounter, he assembles hundreds of images from his own work experience to present the Color Atlas of Forensic Medicine and Pathology. Featuring twice the number of images as any other forensic pathology atlas, the book is filled with high-resolution photos that demonstrate postmortem changes of the human body and the different types of patterns produced in deaths caused by: Natural causes Diagnostic or therapeutic procedures Substance abuse Poisoning Child abuse Firearms Blunt instruments Sharp instruments Burns Asphyxia This easy-to-read atlas, created for medical and non-medical personnel, covers basic and advanced forensic concepts that relate to all manners of deaths. The carefully worded, unambiguous text describing each photo and the side-by-side comparisons of similar, yet different, pathologies make this remarkable atlas a powerful teaching tool for all those who must confront and solve the mystery of human demise. A fully searchable DVD version is also available.

Nutrition plays a key role in prevention of cardiovascular disease, the leading cause of death worldwide. Diet influences a broad spectrum of cardiometabolic risk factors, notably a cluster including excess adiposity, dyslipidemia, impaired glucose metabolism and high blood pressure. In the face of the rapidly increasing incidence of obesity and diabetes, maintaining cardiometabolic health through adoption of a healthy lifestyle is a top public health priority. In this book, Nutrition and Cardiometabolic Health, international experts present state-of-the-art scholarly reviews of dietary and lifestyle effects on metabolic systems associated with cardiovascular health and disease. It covers a broad range of topics including biological and behavioral processes regulating food intake; lifestyle and surgical approaches to weight loss; nutritional considerations for optimal cardiometabolic health across the lifespan; the relationship of macronutrients, whole foods and dietary patterns to diabetes and cardiovascular disease; and diet as a modulator of gene expression, epigenetics and the gut microbiome and the relationship of these traits to disorders of metabolism. This book provides its readers with an authoritative view of the present state of knowledge of dietary effects on cardiometabolic health and will be of interest to nutrition and healthcare professionals alike.

Nanotechnology and regenerative engineering have emerged to the forefront as the most versatile and innovative technologies to foster novel therapeutic techniques and strategies of the twenty-first century. The first edition of Nanotechnology and Tissue Engineering: The Scaffold was the first comprehensive source to explain the developments in nanostructured biomaterials for tissue engineering, the relevance of nanostructured materials in tissue regeneration, and the current applications of nanostructured scaffolds for engineering various tissues. This fully revised second edition, renamed Nanotechnology and Regenerative Engineering: The Scaffold, provides a thorough update to the existing material, bringing together these two unique areas to give a perspective of the emerging therapeutic strategies for a wide audience. New coverage includes: Updated discussion of the importance of scaffolds in tissue engineering Exploration of cellular interactions at the nanoscale Complete range of fabrication processes capable of developing nanostructured scaffolds for regenerative engineering Applications of nanostructured scaffolds for neural, skin, cardiovascular, and musculoskeletal regenerative engineering FDA approval process of nanostructure scaffolds Products based on nanostructured scaffolds Due to the unique and tissue-mimic properties of the nanostructured scaffolds, the past five years have seen a tremendous growth in nanostructured materials for biological applications. The revised work presents the current state-of-the-art developments in nanostructured scaffolds for regenerative engineering.

Phage Display in Biotechnology and Drug Discovery, Second Edition provides a comprehensive view of the impact and promise of phage display in drug discovery and biotechnology. Building on the success of its previous edition, the book discusses current theories, principles, and methods in the field and demonstrates applications for peptide phage display, protein phage display, and the development of novel antibodies. The book provides readers with an overview of the amazing breadth of the impact that phage display technology has had on the study of proteins in general as well as the development of proteins. It will be a valuable resource for those interested in using phage display and recombinant antibodies in basic research and drug discovery. Key Features: Describes the basic principles of phage display and the methods and systems that have been developed for key applications Outlines applications for peptide phage display in the development of vaccines and high- throughput screens as well as the exploration of protein-protein interactions and enzyme substrate characteristics Details the use of phage display in the engineering of protein stability, the identification and mapping of protein-protein interactions, and the development of catalysts Provides broad coverage of the impact of phage display technology on the development of protein therapeutics Presents expert opinions on future challenges in the field

This book considered the biological, ecological, toxicology, and chemical aspects of research topics as they relate to endophytes of grasses. Several chapters reflect the very pragmatic applications of endophytes and endophyte-infected grasses. Other chapters offer future applications for endophytes and are therefore discussed from theoretical viewpoints. This book contains the collective writings of an international group of experts on fungal endophytes of grasses, all of whom are directed toward, understanding, creating, and exploiting the positive aspects of endophytes. With this book, we are attempting to stimulate and facilitate future explorations of the grass endophytes.

This text provides a clear exposition of genetic principles and problems with comprehensive, up-to-date references. Specialists who have collaborated closely with industry give an inside authentic view of the genetics and breeding of industrial microorganisms such as yeasts, filamentous fungi, actinomycetes, pseudomonads, and other bacteria of major industrial significance. This book will be especially valuable to many professionals in the field of microbial genetics.

Although the role of liposomes in drug targeting has been discussed extensively in several reviews and books, there has been no comprehensive coverage of related methodology. This book constitutes the first attempt to put together all aspects of lipsome technology as applied to medical sciences. Volume I deals directly with methods for the preparation of liposomes and auxiliary techniques.

Sodium is concerned with the physiology, pathophysiology, and clinical consequences of altered physiology involving the sodium ion.The first section focuses on the presence and handling of sodium in the normal state. In chapter one, Drs. Solomon and Galey deal with the fundamentals of transport and energy metabolism as they relate to sodium. This is followed by a chapter in which Drs. Gardenswartz and Schrier consider in detail the normal body economy of sodium, and especially the factors (particularly extracellular fluid volume) that regulate the renal handling of sodium and the responses of the various portions of the nephron to these influences.

It is therefore obvious that good patient management necessitates the use of an alternative route of nutritional support in patients unable to eat or absorb an oral diet. This alternative is parenteral nutrition, which is the subject of this book. While there are many texts on the subject of parenteral nutrition, very few if any are directed to the practical details of organizing the delivery of parenteral nutrition from a multidisciplinary point of view. In this publication we present the practice of parenteral nutrition as viewed by a team of a physician, nurse, and pharmacist.

Phosphate in Pediatric Health and Disease provides a state-of-the-art overview of normal physiology, pathophysiology, genetics, clinical and therapeutic aspects of different types of phosphate homeostasis in early life. The book reviews the developmental physiology of phosphate metabolism from the fetus to the adolescent. It describes the pathophysiologic mechanisms associated with perturbations in phosphate homeostasis as well as discusses the different clinical conditions related to abnormal mineral metabolism, parathyroid hormone and vitamin D in infancy, childhood, and adolescence, and the modern diagnostic and therapeutic modalities. This book will benefit pediatricians, endocrinologists, neurologists, nutritionists, and researchers in the field of mineral metabolism.

Written by the foremost researchers in the field, this book gathers together in a single source the many important clinical associations of antiphospholipid antibodies. Antibody-related clotting mechanisms and their relationship to conditions such as recurrent strokes, chorea, multi infarct dementias, a variety of spinal syndromes, Addison's Disease, recurrent miscarriages, and many more are discussed in depth. The importance of these antibodies in 'Primary,' 'Secondary,' and 'Catastrophic' Antiphospholipid Syndrome is highlighted. Each chapter is devoted to a specific internal system and the clinical effects this syndrome has on that system. This authoritative book is an essential addition to medical libraries as well as an invaluable reference for general physicians, internists, rheumatologists, neurologists, cardiologists, nephrologists, endocrinologists, gastroenterologists, pulmonologists, dermatologists, and obstetricians.

The factors affecting blood vitamin C levels are described in detail in this series. Many factors such as aging, smoking, infection, trauma, surgery, hemolysis, hormone administration, heavy metals, pregnancy, alcohol, ionizing radiation and several medicines have been found to cause a disturbance of ascorbic acid metabolism and to reduce blood vitamin C levels. Indeed, abnormalities of ascorbic acid metabolism, due to factors such as smoking, occur much more frequently than does dietary vitamin C deficiency today.It is now known that low blood vitamin C levels are associated with histaminemia (high blood histamine levels), and also that ascorbate-responsive histaminemia is common in apparently healthy people. High blood histamine levels are believed to cause small hemorrhages within the inner walls of the blood vessels and these may lead to the deposition of cholesterol, as an aberrant form of wound healing. Ascorbic acid not only reduces blood histamine levels, but also aids the conversion of cholesterol to bile acids in the liver. The clinical pathological and chemical changes observed in ascorbic acid deficiency are discussed in detail. Several diseases and disorders associated with low blood vitamin C levels are also described. Possible toxic effects resulting from the oxidation of ascorbic acid are noted, and reasons for the use of D-catechin or other chelating fiber to prevent or minimize the release of ascorbate-free radical are detailed. An excellent reference for physicians, nutritionists and other scientists

This book provides a comprehensive summary of data from basic and clinical studies in support of a role for corticotropin-releasing factor (CRF) as a neurotransmitter in the mammalian central nervous system (CNS). It includes descriptions of the anatomy of CRF and its receptors in the CNS, as well as the characterization of CRF receptors and the second messenger systems mediating effects of CRF in the brain. It discusses the autonomic, behavioral, and electrophysiologic effects of CRF administration in the brain. This work also includes a section which covers the role of brain CRF in the etiology and pathophysiology of a variety of neurologic, psychiatric, and endocrine disorders. Endocrinologists, brain researchers, and neuroendocrinologists are among those who will find this reference both useful and interesting.

In Fundamentals of Forensic Photography, Keith Mancini and John Sidoriak offer practical techniques for common situations encountered in forensic documentation. Topics include equipment selection, lighting techniques, crime scene and evidence documentation, macro and micro photography as well as aerial, high speed and computational photography. Techniques for photographic documentation in both the laboratory and the field are discussed.

This unique textbook takes a holistic approach to food poisoning and food hygiene, explaining in clear and non-technical language the causes of food poisoning with practical examples from 'real-life' outbreaks. Now in its seventh edition, the book retains its longstanding clarity, while being completely revised and updated by a new team of editors and contributing authors. Hobbs' Food Poisoning and Food Hygiene gives the reader a practical and general introduction to the relevant micro-organisms that affect food in relation to food safety and foodborne illness. Emphasis is given to the main aspects of hygiene necessary for the production, preparation, sale and service of safe food. Information about the behaviour of microbiological agents in various foods, their ability to produce toxins and the means by which harmful organisms reach food is applied to manufacture and retail procedures, and to equipment and kitchen design. For the first time the book includes coverage of waterborne infections and sewage and, through judicious selection of case examples, indicates the global nature of food and water hygiene today. The contribution of different professional groups to the control of food- and waterborne organisms is also recognized. This book remains an essential course text for students and lecturers dealing with food science, public health, microbiology, environmental health and the food service industry. It also serves as an invaluable handbook for professionals within the food industry, investigators, researchers in higher education and those in the retail trade.

This book provides an authoritative and comprehensive source of information on the biochemical an metabolic aspects of digestion and absorption of different dietary fats and other lipids, with minimal discussion of the physical chemistry of the process, which has been covered in great detail in previous reviews. It is intended for both researchers and practitioners in the biomedical field who require detailed knowledge of the biomedical and metabolic transformations involed in the intestinal digestion and resynthesis of dietary fats and other lipids.

Forensic DNA Technology examines the legal and scientific issues relating to the implementation of DNA print technology in both the crime laboratory and the courtroom. Chapters have been written by many of the country's leading experts and trace the underlying theory and historical development of this technology, as well as the methodology utilized in the Restriction Fragment Length Polymorphism (RFLP) and Polymerase Chain Reaction (PCR) techniques. The effect of environmental contaminants on the evidence and the statistical analysis of population genetics data as it relates to the potential of this technology for individualizing the donor of the questioned sample are also addressed. Other topics include the proposed guidelines for using this technology in the crime laboratory, the perspective of the prosecution and the defense, the legal standards for determining the admissibility and weight of such evidence at trial. Finally, the issues of validation and the standards for interpretation of autoradiograms are brought into focus in a detailed study of actual case work. Forensic scientists, prosecuting attorneys, defense attorneys, libraries, and all scientists working with DNA technology should consider this a "must have" book.

The factors affecting blood vitamin C levels are described in detail in this series. Many factors such as aging, smoking, infection, trauma, surgery, hemolysis, hormone administration, heavy metals, pregnancy, alcohol, ionizing radiation and several medicines have been found to cause a disturbance of ascorbic acid metabolism and to reduce blood vitamin C levels. Indeed, abnormalities of ascorbic acid metabolism, due to factors such as smoking, occur much more frequently than does dietary vitamin C deficiency today.It is now known that low blood vitamin C levels are associated with histaminemia (high blood histamine levels), and also that ascorbate-responsive histaminemia is common in apparently healthy people. High blood histamine levels are believed to cause small hemorrhages within the inner walls of the blood vessels and these may lead to the deposition of cholesterol, as an aberrant form of wound healing. Ascorbic acid not only reduces blood histamine levels, but also aids the conversion of cholesterol to bile acids in the liver. The clinical pathological and chemical changes observed in ascorbic acid deficiency are discussed in detail. Several diseases and disorders associated with low blood vitamin C levels are also described. Possible toxic effects resulting from the oxidation of ascorbic acid are noted, and reasons for the use of D-catechin or other chelating fiber to prevent or minimize the release of ascorbate-free radical are detailed. An excellent reference for physicians, nutritionists and other scientists

In keeping with the etiology theme, it also became apparent that the clinical aspects needed to be strictly separated from the animal aspects of zinc metabolism, a separation that has never previously been attempted. Although this division, like the separation of primary from secondary zinc depletion, may be somewhat arbitrary, it is the author's impression that current knowledge of the truly clinical aspects of zinc metabolism is too often confused with its effects in animals. The two will frequently be similar, but not always. In this book, therefore, animal studies are considered in part 2 (Biochemistry. Only a handful of references to animal studies has been included in part 1 (Clinical). The purpose of this separation is to clearly distinguish animal from human, experimental from clinical. Too many of the animal studies have involved severe and prolonged zinc deficiency or other exaggerated nutritional conditions that cannot be realistically applied in the clinical setting. Furthermore, animal studies are mainly or primary (dietary) zinc depletion, whereas in humans, secondary zinc depletion is more prevalent and has a more diverse etiology.

This volume, the result of an International Conference on Wet Site Archaeology funded by the National Endowment for the Humanities, explores the rewards and responsibilities of recovering unique assemblages from water-saturated deposits. Characteristics common to all archaeological wet sites are identified from Newfoundland to Chile, Polynesia to Florida, and from the Late Pleistocene to the Twentieth Century. Topics include innovative excavation and preservation methods; the need for adequate funding to preserve and analyze the abundant biological and cultural remains recovered only at archaeological wet sites; expanded knowledge of past environments, subsistence, technologies, artistic expressions, skeletal structure, and pathologies; the urgency to inform developers and governmental bodies about the invisible heritage entombed in wetlands that is often destroyed before it can be investigated; a formula for establishing priorities for excavating wet sites; and how to determine when enough of a wet site has been sampled.Many famous sites and discoveries are described in this volume, including Herculaneum, Hoko River, Hontoon Island, Key Marco, Monte Verde, Ozette, Somerset Levels, Windover, bog bodies of Northern Europe, and lake dwellers of Switzerland. Professional and amateur archaeologists, as well as anyone interested in archaeology or the significance of wet site archaeology will find this book fascinating.

These proceedings were published as a result of a workshop sponsored by the Chemoprevention Branch of the National Cancer Institute. The workshop covered a range of topics including calcium and vitamin D in human nutrition; epidemiologic relationships betweencalcium, vitamin D, and colon cancer; the biology of calium and vitamin D at the tissue and cellular level; and enimal and human studies investigating the potential for prevention of colon cancer with calcium and vitamin D.

This book provides an authoritative and comprehensive source of information on the biochemical an metabolic aspects of digestion and absorption of different dietary fats and other lipids, with minimal discussion of the physical chemistry of the process, which has been covered in great detail in previous reviews. It is intended for both researchers and practitioners in the biomedical field who require detailed knowledge of the biomedical and metabolic transformations involed in the intestinal digestion and resynthesis of dietary fats and other lipids.

Editors Fred M. Nordhauser and Wayne P. Olson have gathered a team of 18 experts from multi-national and leading edge companies to explore the advantages and disadvantages of current sterilization technologies. They cover the theory behind the technology, the practical concerns of installation from engineering and product development perspectives, the "how to validate" concern, and the pragmatics of implementation in a manner that will satisfy the regulatory agencies. The broad range of in-depth information on numerous technologies will help readers design sterile manufacturing processes cost effectively and efficiently.

The second edition of Nanotechnology in Biology and Medicine is intended to serve as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of nanotechnology in life sciences. This technology, which is on the scale of molecules, has enabled the development of devices smaller and more efficient than anything currently available. To understand complex biological nanosystems at the cellular level, we urgently need to develop a next-generation nanotechnology tool kit. It is believed that the new advances in genetic engineering, genomics, proteomics, medicine, and biotechnology will depend on our mastering of nanotechnology in the coming decades. The integration of nanotechnology, material sciences, molecular biology, and medicine opens the possibility of detecting and manipulating atoms and molecules using nanodevices, which have the potential for a wide variety of biological research topics and medical uses at the cellular level. This book presents the most recent scientific and technological advances of nanotechnology for use in biology and medicine. Each chapter provides introductory material with an overview of the topic of interest; a description of methods, protocols, instrumentation, and applications; and a collection of published data with an extensive list of references for further details. The goal of this book is to provide a comprehensive overview of the most recent advances in instrumentation, methods, and applications in areas of nanobiotechnology, integrating interdisciplinary research and development of interest to scientists, engineers, manufacturers, teachers, and students.

Now in its Second Edition, Landmark Essays on Rhetoric of Science: Case Studies presents fifteen iconic essays in science studies, rhetorical criticism, and argumentation. Integral to the launch of the Landmark Essays series and renowned for its impact on the then-nascent field of rhetoric of science, this volume returns with a revised introduction and updated contributions to the field, including the work of Leah Ceccarelli, James Wynn, Ashley Rose Mehlenbacher, and Carolyn R. Miller.