In recent years, significant advancements have been made in the management of nutritional deficiency using genome engineering--enriching the nutritional properties of agricultural and horticultural crop plants such as wheat, rice, potatoes, grapes, and bananas. To meet the demands of the rapidly growing world population, researchers are developing a range of new genome engineering tools and strategies, from increasing the nutraceuticals in cereals and fruits, to decreasing the anti-nutrients in crop plants to improve the bioavailability of minerals and vitamins. Genome Engineering for Crop Improvement provides an up-to-date view of the use of genome editing for crop bio-fortification, improved bioavailability of minerals and nutrients, and enhanced hypo-allergenicity and hypo-immunogenicity. This volume examines a diversity of important topics including mineral and nutrient localization, metabolic engineering of carotenoids and flavonoids, genome engineering of zero calorie potatoes and allergen-free grains, engineering for stress resistance in crop plants, and more. Helping readers deepen their knowledge of the application of genome engineering in crop improvement, this book: Presents genetic engineering methods for developing edible oil crops, mineral translocation in grains, increased flavonoids in tomatoes, and cereals with enriched iron bioavailability Describes current genome engineering methods and the distribution of nutritional and mineral composition in important crop plants Offers perspectives on emerging technologies and the future of genome engineering in agriculture Genome Engineering for Crop Improvement is an essential resource for academics, scientists, researchers, agriculturalists, and students of plant molecular biology, system biology, plant biotechnology, and functional genomics.

Maximizing the potential of RNA interference in functional genomics - as well as in the development of therapeutics - continues to be at the forefront of biomedical research. Unlike journal articles, Gene Silencing by RNA Interference: Technology and Application combines essential background to the RNAi field with practical techniques designed by renowned researchers to provide the most diverse and in-depth examination of the subject yet. This book describes methods and protocols for gene silencing and RNA interference. Each chapter provides necessary background to the subject and then gives detailed methods in easy-to-follow steps, along with troubleshooting hints and tips. Following a general and historical introduction, chapters two through eight focus on technical details of the various methods of siRNA design, chemical and enzymatic production, plasmid- and virus-mediated intracellular expression, and other RNAi tools. Chapter nine discusses the exogenous delivery of siRNAs into cells, and the final chapters of the book detail the application of RNAi to dissect gene function in a number of biological systems, including cell-free systems, cultured cells, and whole organisms. From the design and production of RNAi tools to their applications, Gene Silencing by RNA Interference: Technology and Application is the first to present the entire spectrum of activity, design, production, and delivery of RNAi reagents, providing a welcome guide for both academic and commercial use.

This volume contains invited and refereed papers based upon presentations given in the IMA workshop on Computational Modeling in Biological Fluid Dynamics during January of 1999, which was part of the year-long program "Mathematics in Biology." This workshop brought together biologists, zoologists, engineers, and mathematicians working on a variety of issues in biological fluid dynamics. A unifying theme in biological fluid dynamics is the interaction of elastic boundaries with a surrounding fluid. These moving boundary problems, coupled with the equations of incompressible, viscuous fluid dynamics, pose formidable challenges to the computational scientist. In this volume, a variety of computational methods are presented, both in general terms and within the context of applications including ciliary beating, blood flow, and insect flight. Our hope is that this collection will allow others to become aware of and interested in the exciting accomplishments and challenges uncovered during this workshop.

This fantastic CGP Exam Practice Workbook is the perfect companion for Year 1 & 2 of AQA A-Level Biology. It's packed with ultra-realistic exam questions covering every topic students need to know, including a section of mixed (synoptic) questions. We've added in exam tips throughout to make sure there are no unpleasant surprises in their exams! To round things off there are fully worked answers and mark schemes for every question. For study notes and even more practice don't miss the CGP AQA A-Level Biology Complete Revision & Practice guide (9781789080261).

Contents:
Part 1. Fundamental Aspects 1. Principles of Cryobiology Peter Mazur 2. The Water to Ice Transition. Implications for Living Cells Ken Muldrew, Jason Acker, Gloria Elliott, Locksley Mcgann Part 2. Life and Death at Low Temperatures 3. Life in the Polar Terrestrial Environment with a Focus on Algae and Cyanobacteria Josef Elster, Erica Benson 4. Microbial Life in Permafrost. Extended Times in Extreme Conditions Monica Ponder, Tatiana Vishnivetskaya, John Mcgrath and James Tiedje 5. Adaptation of Higher Plants to Freezing Roger Pearce 6. Oxidative Stress in the Frozen Plant. A Free Radical Point of View Erica Benson, David Bremner 7. Physiology, Biochemistry and Molecular Biology of Vertebrate Freeze Tolerance. The Wood Frog Kenneth B. Storey, Janet M. Storey Part 3. Freezing and Banking of Living Resources 8. Preservation of Fungi and Yeasts C. Shuhui Tan, Cor Van Ingen 9. Cryo-Conserving Algal and Plant Diversity. Historical Perspectives and Future Challenges Erica E. Benson 10. Plant Cryopreservation Akira Sakai 11. The Early History of Gamete Cryobiology Stanley P. Leibo 12. Cryobiology of Gametes and the Breeding of Domestic Animals Alban Massip, Stanley P. Leibo, Elizabeth Blesbois 13. Cryopreservation as a Supporting Measure in Species Conservation; "Not The Frozen Zoo!" Amanda R. Pickard, William V. Holt 14. Cryopreservation of Gametes and Embryos of Aquatic Species Tiantian Zhang 15. Fundamental Issues for Cell-Line Banks in Biotechnology and Regulatory Affairs Glyn Stacey Part 4. Medical Applications 16. Mechanisms of Injury Caused by In Vivo Freezing Nathan E Hoffman, John C. Bischof 17. Cryopreservation in Transfusion Medicine and Haematology Andreas Sputtek, Rebekka Sputtek 18. Cryopreservation of Human Gametes and Embryos Barry Fuller, Sharon Paynter, Paul Watson 19. The Scientific Basis for Tissue Banking Monica Wusteman Charles J. Hunt 20. Engineering Desiccation Tolerance in Mammalian Cells. Tools and Techniques Jason P. Acker, Tani Chen, Alex Fowler, Mehmet Toner 21. Stabilization of Cells During Freeze-Drying. The Trehalose Myth John H. Crowe, Lois M. Crowe, Fern Tablin, Willem Wolkers, Ann E. Oliver, Nelly M. Tsvetkova 22. Vitrification in Tissue Preservation. New Developments Mike J. Taylor, Yin C. Song and Kelvin G.M. Brockbank Part 5. The Future of Cryobiology 23. The Future of Cryobiology Nick Lane

Contents:
Part 1. Introduction. M.R. Leary, R.M. Kowalski, An Introduction to Social-clinical Psychology. M.R. Leary, J.E. Maddux, Progress Toward a Viable Interface between Social and Clinical-counseling Psychology. Part 2.
Social Psychological Processes in the Development and Maintenance of Emotional and Behavioral Problems. C.A. Anderson, R.S. Miller, A.L. Riger, J.C. Dill, C. Sedikides, Behavioral and Characterological Attributional Styles as Predictors of Depression and Loneliness: Review, Refinement and Test. C. Peterson, R.S. Vaidya, Explanatory Style, Expectations, and Depressive Symptoms. R.F. Baumeister, T.F. Heatherton, Self-regulation Failure: An Overview. C. Peterson, M.E.P. Seligman, K.H. Yurko, L.R. Martin, H.S. Friedman, Catastrophizing and Untimely Death. B.M. Braginsky, D.D. Braginsky, Schizophrenic Patients in the Psychiatric Interview: An Experimental Study of Their Effectiveness at Manipulation. S. Berglas, E.E. Jones, Drug Choice as a Self-handicapping Strategy in Response to Noncontingent Success. C.S. Crandall, Social Cognition of Binge Eating. M.R. Leary, L.S. Schreindorfer, A.L. Haupt, The Role of Self-esteem in Emotional and Behavioral Problems: Why is Low Self-esteem Dysfunctional? F.D. Fincham, T.N. Bradbury, Marital Satisfaction, Depression, and Attributions: A Longitudinal Analysis. J.E. Hokanson, M.P. Rubert, R.A. Welker, G.R. Hollander, C. Hedeen, Interpersonal Concomitants and Antecedents of Depression among College Students. S. Strack, J.C. Coyne, Social Confirmation of Dysphoria: Shared and Private Reactions to Depression. G. Downey, S.I. Feldman, Implications of Rejection Sensitivity for Intimate Relationships. Part 3. Social Psychological Processes in the Perception and Diagnosis of Psychological Problems. D.L. Rosenhan, On Being Sane in Insane Places. E.J. Langer, R.P. Abelson, A Patient by Any Other Name... Clinical Group Difference in Labeling Bias. J. Copeland, M. Snyder, When Counselors Confirm: A Functional Analysis. J.E. Maddux, The Mythology of Psychopathology: A Social Cognitive View of Deviance, Difference, and Disorder. P.W. Corrigan, D.L. Penn, Lessons from Social Psychology on Discrediting Psychiatric Stigma. Part 4. Social Psychological Processes in Clinical Treatment and Psychological Change. J. Frank, American Psychotherapy in Perspective (Excerpt from Persuasion and Healing). D.R. Forsyth, S.R. Strong, The Scientific Study of Counseling and Psychotherapy: A Unificationist View. J.W. Pennebaker, J.K. Kiecolt-Glaser, R. Glaser, Disclosure of Traumas and Immune Function: Health Implications for Psychotherapy. D. Axsom, J. Cooper, Cognitive Dissonance and Psychotherapy: The Role of Effort Justification in Inducing Weight Loss. B.W. McNeill, C.D. Stoltenberg, Reconceptualizing Social Influence in Counseling: The Elaboration Likelihood Model. E.J. Langer, J. Rodin, The Effects of Choice and Enhanced Personal Responsibility for the Aged: A Field Experiment in an Institutional Setting. W.B. Swann, Jr, The Trouble with Change: Self-verification and Allegiance to the Self. Appendix. C.H. Jordan, M.P. Zanna, How to Read a Journal Article in Social Psychology.

Review: Taurine Deficiency and the Cat.- Taurine Synthesis in Cat and Mouse In Vivo and In Vitro.- Amino Acid Interaction with Taurine Metabolism in Cats.- The Effect of Dietary Supplementation with Cysteic Acid on the Plasma Taurine Concentration of Cats Maintained on a Taurine-Restricted Diet.- The Metabolic Basis for the Taurine Requirement of Cats.- Intestinal Taurine and the Enterohepatic Circulation of Taurocholic Acid in the Cat.- Urinary Excretion of Taurine as a Function of Taurine Intake: Potential for Estimating Taurine Bioavailability in the Adult Cat.- Dilated Cardiomyopathy Associated with Taurine Deficiency in the Domestic Cat: Relationship to Diet and Myocardial Taurine Content.- Reduction of Intrinsic Contractile Function of the Left Ventricle by Taurine Deficiency in Cats.- "Activation" of Alveolar Leukocytes Isolated from Cats Fed Taurine-free Diets.- High Dietary Taurine and Feline Reproduction.- Taurine Distribution in the Cat Muscle: An Immunohistochemical Study.- Review: Myocardial Physiological Effects of Taurine and Their Significance.- Sarcolemmal Actions of Taurine Linked to Altered Phospholipid N-methylation.- Taurine Effects on Ionic Currents in Myocardial Cells.- Taurine Attenuates Contracture Induced by Perfusion with Low Sodium, High Calcium Medium in Chick Hearts.- Effect of Taurine on Intracellular Calcium Dynamics of Cultured Myocardial Cells During the Calcium Paradox.- Intracellular Effects of Taurine: Studies on Skinned Cardiac Preparations.- Effects of Taurine Deficiency on Arrhythmogenesis and Excitation-contraction Coupling in Cardiac Tissue.- Taurine Potentiates the Antiaggregatory Action of Aspirin and Indomethacin.- Antiarrhythmic Action of Taurine.- Mechanism Underlying Physiological Modulation of Myocardial Contraction by Taurine.- Effects of Taurine Depletion on Membrane Electrical Properties of Rat Skeletal Muscle.- Regression of Taurine Depletion in Rhesus Monkeys Deprived of Dietary Taurine Throughout the First Year.- Taurine Transport in the Mouse Cerebral Cortex During Development and Ageing.- Phospholipids, Phospholipid Methylation and Taurine Content in Synaptosomes of Developing Rat Brain.- The Effect of Taurine on the Age-related Decline of the Immune Response in Mice: the Restorative Effect on the T Cell Proliferative Response to Costimulation with Ionomycin and Phorbol Myristate Acetate.- Effects of Taurine Deficiency on Immune Function in Mice.- Review: Recent Studies on Taurine in the Central Nervous System.- Pathologies of the CNS and Associated Taurine Changes.- Taurine Receptor: Kinetic Analysis and Pharmacological Studies.- Evoked Endogenous Taurine Release from Cultured Cerebellar Neurons.- Effect of Hepes on the Uptake of Taurine by Cultured Nervous Cells.- The Trophic Role of Taurine in the Retina. A Possible Mechanism of Action.- Endogenous Regulation of the Taurine Receptor.- Localization of Taurine and Glial Fibrillary Acidic Protein in Human Optic Nerve Using Immunocytochemical Techniques.- Effects of Taurine on Protein Phosphorylation in Mammalian Tissues.- Taurine Protection of Lungs in Hamster Models of Oxidant Injury: a Morphologic Time Study of Paraquat and Bleomycin Treatment.- Taurine and Niacin Offer a Novel Therapeutic Modality in Prevention of Chemically-induced Pulmonary Fibrosis in Hamsters.- Taurine Protects Against Oxidant Injury to Rat Alveolar Pneumocytes.- The Protective Effect of Taurine on the Biomembrane Against Damage Produced by the Oxygen Radical.- Volume Regulatory Fluxes in Glial and Renal Cells.- Cell Volume Changes and Taurine Release in Cerebral Cortical Slices.- L-Glutamate-induced Swelling of Cultured Astrocytes.- Taurine and Volume Regulation in Isolated Nerve Endings.- Hyperosmolarity and Taurine Content, Uptake and Release in Astrocytes.- GABA and Taurine Serve as Respectively a Neurotransmitter and an Osmolyte in Cultured Cerebral Cortical Neurons.- Potassium-stimulated Release of Taurine in A Crude Retinal Preparation O...

Providing complete, step-by-step coverage of the 2008 Edexcel GCE Biology specification, this is the official Student Book for the concept-led approach to the specification. Written by experienced examiners, it offers students motivating and relevant content to improve exam performance and ensure students fulfil their full potential. Allows for regular testing and exam preparation with real Edexcel past questions, provided in the 'Examzone' sections. Supports independent learning through a range of additional resources provided on the ActiveBook CD-ROM, included FREE in the back of each book. Helps students build a wide range of skills, including data analysis, critical evaluation of information, communication and collaborative work. Gives students an in-depth, scientific understanding of the principles covered in each topic, including How Science Works. Helps students easily see how content from the specification is covered through topic overview maps. Written by highly respected and experienced authors.

This book offers a thorough and up-to-date treatment of the use of morphometric procedures in a wide variety of contexts. As one of the most dynamic and popular fields on the contemporary biological scene, morphometrics is gaining notice among researchers and students as a necessary complement to molecular studies in the understanding and maintenance of biodiversity. This is the first reference to meet that growing need.

This one-semester text is designed for an upper-level majors course. Vertebrates features a unique emphasis on function and evolution of vertebrates, complete anatomical detail, and excellent pedagogy. Vertebrate groups are organized phylogenetically, and their systems discussed within such a context. Morphology is foremost, but the author has developed and integrated an understanding of function and evolution into the discussion of anatomy of the various systems.

SAS Programming: The One-Day Course provides a concise introduction to the SAS programming language that gives readers not only a quick start in SAS programming, but also in the basic data manipulations and statistical summaries that are available through SAS. Unlike other introductory texts on the market, this is a pocket-sized reference that does not clutter the presentation of programming techniques by trying to teach statistical methods at the same time. Strong on explanations of how to carry out data manipulations that real-life data often call for, it also contains a short "workbook" appendix, complete with solutions. Datasets and the programming code are available to download from the Web.

With the exception of Poe, no American writer has proven as challenging to biographers as the author of The Red Badge of Courage. Stephen Crane's short, compact life-"a life of fire," he called it-continues to be surrounded by myths and half-truths, distortions and outright fabrications. Mindful of the pitfalls that have marred previous biographies, Paul Sorrentino has sifted through garbled chronologies and contradictory eyewitness accounts, scoured the archives, and followed in Crane's footsteps. The result is the most complete and accurate account of the poet and novelist written to date. Whether Crane was dressing as a hobo to document the life of the homeless in the Bowery, defending a prostitute against corrupt New York City law enforcement, or covering the historic charge up the San Juan hills as a correspondent during the Spanish-American War, his adventures were front-page news. From Sorrentino's layered narrative of the various phases of Crane's life a portrait slowly emerges. By turns garrulous and taciturn, confident and insecure, romantic and cynical, Crane was a man of irresolvable contradictions. He rebelled against tradition yet was proud of his family heritage; he lived a Bohemian existence yet was drawn to social status; he romanticized women yet obsessively sought out prostitutes; he spurned a God he saw as remote yet wished for His presence. Incorporating decades of research by the foremost authority on Crane's work, Stephen Crane: A Life of Fire sets a new benchmark for biographers.

A wide range of research methods for the study of vascular development, from basic laboratory protocols to advanced technologies used in clinical practice, are covered in this work. A range of methodologies such as molecular imaging platforms and signalling analysis, along with tumour models are collated here. Four sections explore in vitro techniques, in vivo and ex vivo manipulations, imaging and histological analysis and other novel techniques in vascular biology. Readers will discover basic methodologies used for analysis of endothelial cell growth in vitro, including co-culture models of vessel formation. Authors also explore isolation and purification of cells and methods for analysis of data and visualization of localized vasculature with modern imaging platforms. Both animal models and human disease are covered in this work. Each chapter contains helpful sections on trouble shooting, additional notes and links, supporting the reader to carry out protocols. This book will appeal to students, researchers and medical professionals working in all vascular-linked fields such as cardio- and cerebrovascular, cancer and dementia.

This volume contains papers based on the workshop "Energy and Information Transfer in Biological Systems: How Physics Could Enrich Biological Understanding," held in Italy in 2002. The meeting was a forum aimed at evaluating the potential and outlooks of a modern physics approach to understanding and describing biological processes, especially regarding the transition from the microscopic chemical scenario to the macroscopic functional configurations of living matter. In this frame some leading researchers presented and discussed several basic topics, such as the photon interaction with biological systems also from the viewpoint of photon information processes and of possible applications; the influence of electromagnetic fields on the self-organization of biosystems including the nonlinear mechanism for energy transfer and storage; and the influence of the structure of water on the properties of biological matter.

An entertaining, instructive, diverse, and unusual book, Light and Dark: An Exploration in Science, Nature, Art and Technology encompasses a wide range of topics not normally found in one book.
With more than 100 diagrams, graphs, and figures, the subjects discussed include the history of artificial lighting, eclipse cycles, light-sensitive eyeglasses, rainbows, art, bioluminescence, the clock setting at the South Pole, zebra stripe patterns, lighthouses, color perception, the harvest moon, and how information and speech can be conveyed by light from the sun or a laser.
The book encourages readers to take a more careful look at many familiar phenomena, such as the variations in the duration of twilight through the year and the ability of human vision to misinterpret patterns of lines under certain conditions. It describes the anatomical peculiarities of four-eyed fish and explains how the Jewish calendar contrives to follow both solar and lunar cycles. It also presents the reasons why tortoise shell cats are almost always female. Readers are informed where they can see 19th century military equipment that could convey messages rapidly over vast differences.

Foreword by:
Joy Hendry

Foreword by:
Joy Hendry

This book shows how human activity on local, regional and global scales has perturbed natural biogeochemical cycles, "colliding" with Nature. The authors demonstrate how the scale and intensity of human-induced destruction of Nature and resultant feedback mechanisms have continuously expanded. They consider the likelihood of increasing numbers of natural disasters as a result of such activities, and propose that sustainable development become a principal research topic for the 21st Century.

The purpose of this volume is to present and discuss the many rich properties of the dynamical systems that appear in life science and medicine. It provides a fascinating survey of the theory of dynamical systems in biology and medicine. Each chapter will serve to introduce students and scholars to the state-of-the-art in an exciting area, to present new results, and to inspire future contributions to mathematical modeling in life science and medicine.