Metastasis to bone is a common event in cancer. However, due to the skeleton's unique structure, exploring how cancer cells target the skeleton and interact with the bone microenvironment is challenging. The Biology of Skeletal Metastases covers areas that are important to both clinicians and basic scientists seeking an enhanced understanding of mechanisms of skeletal metastasis, as well as descriptions of cutting edge therapies for skeletal metastases.

Both increased efforts by many investigators and advances in research methodologies have provided a wealth of information in the area of skeletal metastases. The Biology of Skeletal Metastases brings together experts to describe these many advances. This book provides background in basic bone biology and biology of metastasis for novice investigators and highlights many advances in this challenging field for the experienced investigator.

Electron microscopy is frequently portrayed as a discipline that stands alone, separated from molecular biology, light microscopy, physiology, and biochemistry, among other disciplines. It is also presented as a technically demanding discipline operating largely in the sphere of "black boxes" and governed by many absolute laws of procedure. At the introductory level, this portrayal does the discipline and the student a disservice. The instrumentation we use is complex, but ultimately understandable and, more importantly, repairable. The procedures we employ for preparing tissues and cells are not totally understood, but enough information is available to allow investigators to make reasonable choices concerning the best techniques to apply to their parti cular problems. There are countless specialized techniques in the field of electron and light microscopy that require the acquisition of specialized knowledge, particularly for interpretation of results (electron tomography and energy dispersive spectroscopy immediately come to mind), but most laboratories possessing the equipment to effect these approaches have specialists to help the casual user. The advent of computer operated electron microscopes has also broadened access to these instruments, allowing users with little technical knowledge about electron microscope design to quickly become operators. This has been a welcome advance, because earlier instru ments required a level of knowledge about electron optics and vacuum systems to produce optimal photographs and to avoid "crashing" the instruments that typically made it difficult for beginners."

Is talent the only key to scientific success? In fact, the answer is: No'. Management and organisation do make a real, significant difference between success and failure in science. This book presents a clear survey of the critical success factors in biomedical research laboratories. Based on an international, comparative study of 71 research laboratories in medical faculties, large health research institutes and innovative pharmaceutical companies, ready-to-use guidelines are offered to those who are responsible for the management of research groups. Dr. Omta is biochemist and has played a key role in the development of the EU Biotechnology Network. He has performed the comparative study for this book in the position of Managing Director of the Institute for Research in Extramural Medicine in Amsterdam. The author has recently been appointed as Associate Professor at the Faculty of Management and Organisation at the University of Groningen, the Netherlands. This work is a unique guide for heads, professors, or managers of (biomedical) research laboratories in universities, research institutes and innovative pharmaceutical companies, who are seeking rational tools for increasing the performance and effectiveness of their research groups.

For introductory biology course for science majors Focus. Practice. Engage. Built unit-by-unit, Campbell Biology in Focus achieves a balance between breadth and depth of concepts to move students away from memorization. Streamlined content enables students to prioritize essential biology content, concepts, and scientific skills that are needed to develop conceptual understanding and an ability to apply their knowledge in future courses. Every unit takes an approach to streamlining the material to best fit the needs of instructors and students, based on reviews of over 1,000 syllabi from across the country, surveys, curriculum initiatives, reviews, discussions with hundreds of biology professors, and the Vision and Change in Undergraduate Biology Education report. Maintaining the Campbell hallmark standards of accuracy, clarity, and pedagogical innovation, the 3rd Edition builds on this foundation to help students make connections across chapters, interpret real data, and synthesize their knowledge. The new edition integrates new, key scientific findings throughout and offers more than 450 videos and animations in Mastering Biology and embedded in the new Pearson eText to help students actively learn, retain tough course concepts, and successfully engage with their studies and assessments. Also available with Mastering Biology By combining trusted author content with digital tools and a flexible platform, Mastering personalizes the learning experience and improves results for each student. Built for, and directly tied to the text, Mastering Biology enables an extension of learning allowing students a platform to practice, learn, and apply outside of the classroom. Note: You are purchasing a standalone product; Mastering Biology does not come packaged with this content. Students, if interested in purchasing this title with Mastering Biology ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If you would like to purchase both the physical text and Mastering Biology search for: 0134875044 / 9780134875040 Campbell Biology in Focus Plus Mastering Biology with Pearson eText -- Access Card Package Package consists of: 0134710673 / 9780134710679 Campbell Biology in Focus 013487451X / 9780134874517 Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology in Focus

This book deals with the application of mathematics in modeling and understanding physiological systems, especially those involving rhythms. It is divided roughly into two sections. In the first part of the book, the authors introduce ideas and techniques from nonlinear dynamics that are relevant to the analysis of biological rhythms. The second part consists of five in-depth case studies in which the authors use the theoretical tools developed earlier to investigate a number of physiological processes: the dynamics of excitable nerve and cardiac tissue, resetting and entrainment of biological oscillators, the effects of noise and time delay on the pupil light reflex, pathologies associated with blood cell replication, and Parkinsonian tremor. One novel feature of the book is the inclusion of classroom-tested computer exercises throughout, designed to form a bridge between the mathematical theory and physiological experiments. This book will be of interest to students and researchers in the natural and physical sciences wanting to learn about the complexities and subtleties of physiological systems from a mathematical perspective. The authors are members of the Centre for Nonlinear Dynamics in Physiology and Medicine. The material in this book was developed for use in courses and was presented in three Summer Schools run by the authors in Montreal.

This volume presents the results of biological and medical research with the statistical methods used to obtain them. Nowadays the fields of biology and experimental medicine rely on techniques for processing of experimental data and for the evaluation of hypotheses. It is increasingly necessary to stimulate awareness of the importance of statistical techniques (and of the possible traps that they can hide) by using real data in concrete situations drawn from research activity.

This book presents selected conference proceedings from the 25th Biennial Asian Association for Biology Education Conference. It clarifies the differences between the structure of biology education for educators and researchers. It solves open problems by creating a bridge between biological research and its application in education and the sustainable development of communities. The book's first topic is Biology Education in an X, Y, Z World, which provides ideas for how biology can be taught in innovative ways. The second topic, The Endangered Planet - How can Biology Education Help? discusses how humans depend on other species for survival and how they have the power to cause or to prevent extinctions. The third and final topic, Research in Biology, encompasses the growing wealth of biological information resulting from scientific research, especially in universities. Educators can use these findings to enhance their teaching.

Leading biostatisticians and biomedical researchers describe many of the key techniques used to solve commonly occurring data analytic problems in molecular biology, and demonstrate how these methods can be used in the development of new markers for exposure to a risk factor or for disease outcomes. Major areas of application include microarray analysis, proteomic studies, image quantitation, genetic susceptibility and association, evaluation of new biomarkers, and power analysis and sample size.

For the first time, world-leading experts in the area of cellular signaling have joined to the production of a book on Smad signal transduction. Smads are the principal intracellular effectors of TGF-b family members that control numerous cellular responses with critical roles in development and in tissue homeostasis. In a series of 22 cutting-edge chapters, forward looking reviews of Smads are provided that cover their discovery, evolution, role in development, mechanism of action and regulation, and how deregulation in Smad signalling contributes to human diseases. Written for an audience with basic understanding of molecular and cell biology, this volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.

This study of biological invasions introduces dynamic concepts into biogeography and spatial concepts into ecology. By using mathematical models from epidemiology and human geography generalizations can be made and it is shown that apparently static species ranges contain dynamic internal parameters.

Advances in Quantum Methods and Applications in Chemistry, Physics, and Biology includes peer-reviewed contributions based on carefully selected presentations given at the 17th International Workshop on Quantum Systems in Chemistry, Physics, and Biology. New trends and state-of-the-art developments in the quantum theory of atomic and molecular systems, and condensed matter (including biological systems and nanostructures) are described by academics of international distinction.

Wir alle kennen das: Wir konnten (vielleicht) schon mal erklaren, warum es auf der einen Seite des Berges regnet und auf der anderen nicht, wie GPS-Navigation funktioniert, oder warum ein Ei in der Mikrowelle explodiert aber heute kriegen wir das nicht mehr uberzeugend hin. Wie schade! Und: Wie gut, dass in diesem Buch der bekannte Wissenschaftsvermittler Jo Hermans viele dieser Alltagsphanomene nun so anschaulich erklart, dass wir vergnuglich schmokern konnen und dabei vergessenes Wissen auffrischen und Neues dazulernen. Natur, Licht und Farbe, rundum das Haus Nein, es braucht wirklich kein Physikstudium, um zu verstehen, warum Eis so glatt ist oder Fragen zu klaren wie die, ob man wirklich im Dunkeln besser hort oder man seine Wohnung mit dem Kuhlschrank kuhlen kann. Zumal Jo Hermans alles dafur tut, uns die Lekture so abwechslungsreich wie moglich zu gestalten. Sich amusieren und gleichzeitig etwas lernen das geht also doch! Es werden funf Themenbereiche abgedeckt: freie Natur, Fahrrad und Auto, Licht und Farbe, Rundum das Haus, Gerausch und Horen. Verruckte Flummis, tollkuhne Weinglaser: Experimentieren macht Spass! Fur Leser, die obendrein gerne etwas ausprobieren, geizt Hermans nicht mit Vorschlagen fur Experimente: ob Kaffeebechermusik, Lichtzerlegung mithilfe von CDs, verruckte Flummis oder tollkuhnes Weinglas. Uberraschungen garantiert und inklusive! Und die Besserwisser unter den Lesern finden zusatzliche Informationen in den eingestreuten Boxen.

Alfred North Whitehead is arguably the most original 20th-century philosopher of nature and metaphysics. In recent decades a number of physicists have produced ground-breaking new theories in fundamental physics influenced by his process philosophy. In contrast, few biologists are even aware that Whitehead's radical rethinking of the Cartesian assumptions implicit in 19th-century sciences might be relevant to their enterprise. This book seeks to fill this gap by exploring how Whitehead's process ontology might provide a new philosophical foundation for the biosciences of the 21st century. The central premise shared by all of the volume's authors is the idea that all living processes are irreducible processes. Each chapter focuses on assumptions implicit in some of the core concepts of biology - such as organism, evolution, information, and teleology - that play crucial explanatory roles in the biosciences, but as metaphysical concepts fall outside its purview. The authors each identify important shortcomings implicit in contemporary biological paradigms and show how an approach grounded in a process-oriented metaphysics can avoid them.

The newest edition of Knisely's Student Handbook for Writing in Biology is the helping hand your students are looking for, offering the support they need to write within the conventions of biology. Topics range from reading technical literature and writing scientific papers, to preparing lab reports and giving oral presentations of scientific findings. Students get practical advice from MS Office appendices, tutorial videos, and various checklists. Examples and resources throughout the text show not just what to do, but how to do it. The newest edition mirrors the ways students use online resources and social media platforms for research, making sure the information is both credible and relevant. A new statistics chapter covers the application of descriptive statistics to actual datasets and selected tests of significance. The newest edition of Knisely's Student Handbook for Writing in Biology is the helping hand your students are looking for, offering the support they need to write within the conventions of biology. Topics range from reading technical literature and writing scientific papers, to preparing lab reports and giving oral presentations of scientific findings. Students get practical advice from MS Office appendices, tutorial videos, and various checklists. Examples and resources throughout the text show not just what to do, but how to do it. The newest edition mirrors the ways students use online resources and social media platforms for research, making sure the information is both credible and relevant. A new statistics chapter covers the application of descriptive statistics to actual datasets and selected tests of significance. The newest edition of Knisely's Student Handbook for Writing in Biology is the helping hand your students are looking for, offering the support they need to write within the conventions of biology. Topics range from reading technical literature and writing scientific papers, to preparing lab reports and giving oral presentations of scientific findings. Students get practical advice from MS Office appendices, tutorial videos, and various checklists. Examples and resources throughout the text show not just what to do, but how to do it. The newest edition mirrors the ways students use online resources and social media platforms for research, making sure the information is both credible and relevant. A new statistics chapter covers the application of descriptive statistics to actual datasets and selected tests of significance.

Phospholipases A2: Brain Phospholipases and their Role in Signal Transduction; A.A. Farooqui, et al. Cell Signaling and Essential Fatty Acids: Reciprocal Regulation of Fatty Acid Release in the Brain by GABA and Glutamate; D.L. Birkle Metabolites of Essential Fatty Acids and Other MembraneDerived Second Messengers in Cell Signaling: A Role for the Arachidonic Acid Cascade in Fast Synaptic Modulation A. Volterra, et al. Dietary Supply of Essential Fatty Acids, Synaptogenesis, and Photoreceptor Biogenesis: Network of Signal Transduction Pathways Involving Lipids; R. Bell et al. Essential Fatty Acids, Excitable Membrane Phospholipids, and Pathophysiology: Conservation of Docosahexaenoic Acid in the Retina; R.E. Anderson, et al. Essential Fatty Acids and Excitable Membrane Phospholipids: Disposition Kinetics of Phospholipid Liposomes; P. Palatini 32 additional articles. Index.

Much of this book was written during a sabbatical visit by J. C. H. S. to the Max Planck Institute in Stuttgart during 1991. We are therefore grateful to Professors M. Ruhle and A. Seeger for acting as hosts during this time, and to the Alexander von Humbolt Foundation for the Senior Scientist Award which made this visit possible. The Ph. D. work of one of us (J. M. Z. ) has also provided much of the background for the book, together with our recent papers with various collaborators. Of these, perhaps the most important stimulus to our work on convergent-beam electron diffraction resulted from a visit to the National Science Foundation's Electron Microscopy Facility at Arizona State University by Professor R. H(lJier in 1988, and from a return visit to Trondheim by J. C. H. S. in 1990. We are therefore particularly grateful to Professor H(lJier and his students and co-workers for their encouragement and collaboration. At ASU, we owe a particular debt of gratitude to Professor M. O'Keeffe for his encouragement. The depth of his under standing of crystal structures and his role as passionate skeptic have frequently been invaluable. Professor John Cowley has also been an invaluable sounding board for ideas, and was responsible for much of the experimental and theoretical work on coherent nanodiffraction. The sections on this topic derive mainly from collaborations by J. C. H. S. with him in the seventies."

From its early days in the 1950s, the electron microanalyzer has offered two principal ways of obtaining x-ray spectra: wavelength dispersive spectrometry (WDS), which utilizes crystal diffraction, and energy dispersive spectrometry (EDS), in which the x-ray quantum energy is measured directly. In general, WDS offers much better peak separation for complex line spectra, whereas EDS gives a higher collection efficiency and is easier and cheaper to use. Both techniques have undergone major transformations since those early days, from the simple focusing spectrometerand gas proportional counter of the 1950s to the advanced semiconductor detectors and programmable spectrometersoftoday. Becauseofthesedevelopments, thecapabilities and relative merits of EDS and WDS techniques have been a recurring feature of microprobeconferences for nearly40 years, and this volume bringstogetherthepapers presented at the Chuck Fiori Memorial Symposium, held at the Microbeam Analysis Society Meeting of 1993. Several themes are apparent in this rich and authoritative collection of papers, which have both a historical and an up-to-the-minute dimension. Light element analysis has long been a goal of microprobe analysts since Ray Dolby first detected K radiation with a gas proportional counter in 1960. WDS techniques (using carbon lead stearate films) were not used for this purpose until four years later. Now synthetic multilayers provide the best dispersive elements for quantitative light element analy sis-still used in conjunction with a gas counter."

Pulse Dipolar Electron Spin Resonance: Distance Measurements by Peter P. Borbat, Jack H. Freed.Interpretation of Dipolar EPR Data in Terms of Protein Structure, by Gunnar Jeschke.Site-Directed Nitroxide Spin Labeling of Biopolymers, by Sandip A. Shelke and Snorri Th. Sigurdsson. Metal-Based Spin Labeling for Distance Determination, by Daniella Goldfarb. Structural Information from Spin-Labelled Membrane-Bound Proteins, by Johann P. KLare, Heinz-Jurgen Steinhoff. Structural Information from Oligonucleotides, by Richard Ward and Olav Schiemann. Orientation selective DEER using rigid spin labels, cofactors, metals, and clusters, by Claudia E. Tait, Alice M. Bowen, Christiane R. Timmel, Jeffrey Harmer