vi on geometric probability is included, students can be expected to create a few simple programs like those shown, but for other geometries. I am indebted to Tom Hare for critical reviews of the material and an endless enthusiasm to debate and derive stereological relationships; to John Matzka at Plenum Press for patiently instructing me in the intricacies of typesetting; to Chris Russ for helping to program many of these measurement techniques; and especially to Helen Adams, both for her patience with my creative fever to write yet another book, and for pointing out that the title, which I had intended to contrast to "theoretical stereology," can also be understood as the antonym of "impractical stereology." John C. Russ Raleigh, NC July, 1986 Chapter 1: Statistics 1 Accuracy and precision 1 The mean and standard deviation 5 Distributions 7 Comparison 13 Correlation 18 Nonlinear fitting 19 Chapter 2: Image Types 23 Planar sections 23 Projected images 25 Finite sections 28 Space-filling structures and dispersed phases 29 Types of images and contrast mechanisms 31 Sampling 32 Chapter 3: Manual Methods 35 Volume fraction 35 Surface density 38 Contiguity 41 Mean intercept length 42 Line density 43 Grain size determination 55 Curvature 48 Reticles to aid counting 49 Magnification and units 51 Chapter4: Size Distributions 53 Intercept length in spheres 53 Nonspherical shapes 57 Corrections for finite section thickness 59 Lamellae 61 Measurement of profile size 62 Nonspherical particles 69 vii Contents viii Chapter 5: Computer Metlwds 73

By the year 2050, the world's population is expected to reach nine billion. To feed and sustain this projected population, world food production must increase by at least 50 percent on much of the same land that we farm today. To meet this staggering challenge, scientists must develop the technology required to achieve an "evergreen" revolution -- one that increases crop productivity without degrading natural resources. With 30 percent new material, the updated and revised third edition of Growth and Mineral Nutrition of Field Crops covers all aspects of crop growth and mineral nutrition that contribute to sustainable, high-yield agriculture. Bringing together international scientific knowledge of crop production and the impacts of agriculture on the environment, this book: * Includes two new chapters on remediation of heavy-metal contaminated soils and cover crops * Covers theoretical and practical aspects of mineral nutrition of field crops * Provides recommendations for judicious use of fertilizers, which will reduce cost of crop production and enhance high crop yields without risking environmental pollution * Provides growth patterns for annual crops and forages * Includes a handful of color pictures of nutrient deficiencies for easy diagnostic purposes To make the book as practical as possible, each chapter is supported by experimental results and extensive references. A large number of figures and tables are also included to save readers time when researching. The overall emphasis of this reference is on the soil's ability to sustain high crop yields and a healthy human population.

Mammalian cells are to a large extent controlled by the environment. Dif- fusible factors (growth factors, cytokines, and hormones) released by oth- er cells in the body bind to and activate receptors localized at the cell sur- face. In the case of the fibroblast growth factor receptor, there seems to be receptors both at the plasma membrane and in the nucleus. Cellular recep- tors control growth, apoptosis, immune function, differentiation, develop- and upon dysregulation, cancer progression and metastasis. Upon li- ment, gand binding, most receptors are internalized. However, the mechanisms of endocytosis are diverse, and receptors are taken into cells from different membrane microdomains. Activation of receptors results in two important interconnected processes, namely, signal transduction and endocytosis. In- terestingly, signal transduction controls endocytosis and endocytosis con- trols signalling. In both processes sequential formation of transient protein machineries is crucial. Currently, characterization of such complex ma- chineries is advancing rapidly. It has recently become appreciated that sev- eral post-translational modifications directly control the affinity of pro- tein-protein interactions. This volume of Current Topics in Microbiology and Immunology focuses on the recent understanding of signalling from in- ternalized activated growth factor receptors. This includes information on pathways by which the rate and specificity of endocytosis and intracellular sorting are controlled. It further includes information on how specialized signalling and trafficking platforms are formed at the plasma membrane and on intracellular vesicles.

This book provides the readers with a timely guide to the application of biomimetic principles in architecture and engineering design. As a result of a combined effort by two internationally recognized authorities, the biologist Werner Nachtigall and the architect Goeran Pohl, the book describes the principles which can be used to compare nature and technology, and at the same time it presents detailed explanations and examples showing how biology can be used as a source of inspiration and "translated" in building and architectural solutions (biomimicry). Even though nature cannot be directly copied, the living world can provide architects and engineers with a wealth of analogues and inspirations for their own creative designs. But how can analysis of natural entities give rise to advanced and sustainable design? By reporting on the latest bionic design methods and using extensive artwork, the book guides readers through the field of nature-inspired architecture, offering an extraordinary resource for professional architects, engineers, designers and urban planners, as well as for university teachers, researchers and students. Natural evolution is seen throughout the book as a powerful resource that can serve architecture and design by providing innovative, optimal and sustainable solutions.

With businesses becoming ever more competitive, marketing strategies need to be more precise and performance oriented. Companies are investing considerably in analytical infrastructure for marketing. This new volume, Marketing Analytics: A Machine Learning Approach, enlightens readers on the application of analytics in marketing and the process of analytics, providing a foundation on the concepts and algorithms of machine learning and statistics. The book simplifies analytics for businesses and explains its uses in different aspects of marketing in a way that even marketers with no prior analytics experience will find it easy to follow, giving them to tools to make better business decisions. This volume gives a comprehensive overview of marketing analytics, incorporating machine learning methods of data analysis that automates analytical model building. The volume covers the important aspects of marketing analytics, including segmentation and targeting analysis, statistics for marketing, marketing metrics, consumer buying behavior, neuromarketing techniques for consumer analytics, new product development, forecasting sales and price, web and social media analytics, and much more. This well-organized and straight-forward volume will be valuable for marketers, managers, decision makers, and research scholars, and faculty in business marketing and information technology and would also be suitable for classroom use.

Next-generation DNA and RNA sequencing has revolutionized biology and medicine. With sequencing cost continuously dropping and our ability to generate large datasets rising, data analysis becomes more important than ever. Next-Generation Sequencing Data Analysis walks readers through NGS data analysis step-by-step for a wide range of NGS applications. For each NGS application, this book covers topics from experimental design, sample processing, sequencing strategy formulation, to sequencing reads quality control, data preprocessing, reads mapping or assembly, and more advanced stages that are specific to each application. Major applications include: RNA-seq: both bulk and single-cell (separate chapters) Genotyping and variant discovery through whole genome/exome sequencing Clinical sequencing and detection of actionable variants De novo genome assembly ChIP-seq to map protein-DNA interactions Epigenomics through DNA methylation sequencing Metagenome sequencing for microbiome analysis Before detailing the analytic steps for each of these applications, the book presents introductory cellular and molecular biology as a refresher mostly for data scientists, the ins and outs of widely used NGS platforms, and an overview of computing needs for NGS data management and analysis. The book concludes with a chapter on the changing landscape of NGS technologies and data analytics. The second edition of this book builds on the well-received first edition by providing updates to each chapter. Two brand new chapters are added to meet rising data analysis demands on single-cell RNA-seq and clinical sequencing. The increasing use of long-reads sequencing has also been reflected in all NGS applications. This book discusses concepts and principles that underlie each analytic step, along with software tools for implementation. It highlights key features of the tools while omitting tedious details to provide an easy-to-follow guide for practitioners in life sciences, bioinformatics, biostatistics, and data science. Tools introduced in this book are open-source and freely available.

A "health disparity" refers to a higher burden of illness, injury, disability, or mortality experienced by one group relative to another. These disparities may be due to many factors including age, income, race, etc. This book will focus on their estimation, ranging from classical approaches including the quantification of a disparity, to more formal modelling, to modern approaches involving more flexible computational approaches. Features: * Presents an overview of methods and applications of health disparity estimation * First book to synthesize research in this field in a unified statistical framework * Covers classical approaches, and builds to more modern computational techniques * Includes many worked examples and case studies using real data * Discusses available software for estimation The book is designed primarily for researchers and graduate students in biostatistics, data science, and computer science. It will also be useful to many quantitative modelers in genetics, biology, sociology, and epidemiology.

This easy-to-follow manual describes tested procedures used to prepare biological samples for scanning and transmission electron microscopy, as well as methods for cytochemistry, immunocytochemistry, and scientific photography. The work is structured to clearly define testing objectives, necessary materials, procedural steps, and expected results; a list of references and trouble shooting techniques round out the text.

Preclinical Drug Development, Second Edition discusses the broad and complicated realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology to industry trends and regulatory expectations to requirements that support clinical trials. Highlights of the Second Edition include: Pharmacokinetics Modeling and simulation Formulation and routes of administration Toxicity evaluations The assessment of drug absorption and metabolism Interspecies scaling Lead molecule selection and optimization via profiling Screening using in silico and in vitro toxicity evaluations The book also includes case studies on preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development, a review of ICH preclinical guidelines, and experimental methods used to study membrane drug transport and metabolism. This guide is a fundamental resource for medicinal chemists, biologists, and other specialists in the drug development sciences.

Stephen J. Gould s greatest contribution to science is a revised version of the theory of evolution which offers today a useful framework for understanding progress in many evolutionary fields. His intuitions about the conjunction of evolution and development, the role of ecological factors in speciation, the multi-level interpretation of the units of selection, and the interplay between functional pressures and constraints all represent fruitful lines of experimental research. His opposition to the progressive representations of evolution, the gene-centered view of natural history, or the adaptationist just-so stories has also left its mark on current biology.

In May 2012, at the Istituto Veneto di Scienze, Lettere ed Arti in Venice, an international panel of scientists and philosophers discussed Stephen J. Gould s legacy, ten years after his death. This book presents a selection of those contributions, chosen for their interest and importance. A broad range of themes are covered: Gould s contribution to evolutionary theory, including the concept of punctuated equilibria and the importance of his pluralism; the Gouldian view of genome and development; Gould s legacy in anthropology; and, finally, the significance of his thought for the human sciences.

This book provides a fascinating appraisal of the cultural legacy of one of the world s greatest popular writers in the life sciences. This is the first time that scientists including some of Gould s personal friends and co-authors of papers of momentous importance such as Niles Eldredge have come together to strike a balanced view of Gould's intellectual heritage."

This book uses the terminology and best practices recommended by the Scientific Working Group for Forensic Anthropology (SWGANTH). The sixth edition has been fully updated in light of recent developments, incorporating new and improved methods as well as global data. This accessible and engaging text offers an array of features to support teaching and learning, including: boxed case studies extensive figures and photographs chapter summaries and student exercises a glossary of terms further resources via a companion website.

Suitable for both concept- and context-led approaches, this Revision Guide is Edexcel's own resource for the 2008 Edexcel GCE Biology specification. Written by experienced examiners, it features guidance from the people who write and mark exam papers and draws on real exam data from Edexcel's ResultsPlus service. 'ResultsPlus' Examiner feedback draws on examiner expertise and real past exam data to help students avoid common pitfalls and build better answers. Exam-style questions - including the multiple-choice style - offer plenty of practice ahead of the exam. Worked examples provide step-by-step guidance on how totackle exam questions. Guidance on Practical Assessment helps students to write better AS visit/case study and practical reports. Thinking tasks, quick questions and checklistsenable students to track their own progress and revise more effectively.

Suitable for both concept- and context-led approaches, this book features: 'ResultsPlus' Examiner feedback which draws on past exam data to help students avoid common pitfalls and build better answers. Exam-style questions - including the multiple-choice style - to offer plenty of practice ahead of the exam. Worked examples that provide step-by-step guidance on how to tackle exam questions. Guidance on Practical Assessment helps students to write better AS visit/case study and practical reports. Thinking tasks, quick questions and checklists enable students to track their own progress and revise more effectively.

With addiction a key target for drug discovery efforts, this book fills an important and timely need for medicinal chemists who need to understand complex neuroscience issues. The author illustrates medicinal chemistry's prominent role in treating addiction and covers specific drugs of abuse including narcotics, stimulants, depressants, nicotine, and marijuana.

- Interprets complex neuro- biological and pharmacological information, like the drug-reward system, for medicinal chemists- Emphasizes neurotransmitters and neurochemical mechanisms of addictive drugs- Pulls together information on the many potential drug targets for treating addiction- Stresses unique medicinal chemistry problems when describing pharmacology testing methods and drug development

This is the second volume of Advances in Acoustic Microscopy. It continues the aim of presenting applications and developments of techniques that are related to high-resolution acoustic imaging. We are very grateful to the authors who have devoted considerable time to preparing these chapters, each of which describes a field of growing importance. Laboratories that have high-performance acoustic microscopes are frequently asked to examine samples for which the highest available resolution is not necessary, and the ability to penetrate opaque layers is more significant. Such applications can be thought of as bridging the gap be tween acoustic microscopy at low gigahertz frequencies, and on the one hand nondestructive testing of materials at low megahertz frequencies and on the other hand medical ultrasonic imaging at low megahertz frequencies. Commercial acoustic microscopes are becoming increasingly available and popular for such applications. We are therefore delighted to be able to begin the volume with chapters from each of those two fields. The first chapter, by Gabriele Pfannschmidt, describes uses of acoustic microscopy in the semiconductor industry. It provides a splendid balance to the opening chapter of Volume 1, which came from a national research center, being written from within a major European electronics industry itself. Dr Pfann schmidt describes the use of two quite different types of acoustic microscopes, and points out the advantages of each for specific purposes.

Biology is the natural science that studies life on our planet: from fungi to fossils and ecosystems to extremophiles, there is a whole world waiting to be discovered.Mind Maps: Biology helps you to understand the natural world and to learn its language by exploring ten mind maps, which are powerful tools for visual learning and understanding. Complex ideas are explained using text and illustrations that are easy to follow. Featuring specially commissioned, hand-drawn maps, diagrams and doodles, together with an expert analysis of concepts, this book provides a wealth of visual information across a range of complex subjects.

The first book devoted exclusively to a highly popular, relatively new detection technique Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques presents a comprehensive review of CAD theory, describes its advantages and limitations, and offers extremely well-informed recommendations for its practical use. Using numerous real-world examples based on contributors professional experiences, it provides priceless insights into the actual and potential applications of CAD across a wide range of industries. Charged aerosol detection can be combined with a variety of separation techniques and in numerous configurations. While it has been widely adapted for an array of industrial and research applications with great success, it is still a relatively new technique, and its fundamental performance characteristics are not yet fully understood. This book is intended as a tool for scientists seeking to identify the most effective and efficient uses of charged aerosol detection for a given application. Moving naturally from basic to advanced topics, the author relates fundamental principles, practical uses, and applications across a range of industrial settings, including pharmaceuticals, petrochemicals, biotech, and more. * Offers timely, authoritative coverage of the theory, experimental techniques, and end-user applications of charged aerosol detection * Includes contributions from experts from various fields of applications who explore CAD s advantages over traditional HPLC techniques, as well its limitations * Provides a current theoretical and practical understanding of CAD, derived from authorities on aerosol technology and separation sciences * Features numerous real-world examples that help relate fundamental properties and general operational variables of CAD to its performance in a variety of conditions Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques is a valuable resource for scientists who use chromatographic techniques in academic research and across an array of industrial settings, including the biopharmaceutical, biotechnology, biofuel, chemical, environmental, and food and beverage industries, among others.

In the past fifteen years there has been considerable interest in neural circuits that initiate behavior patterns. For many types of behaviors, this involves decision-making circuits whose primary elements are neither purely sensory nor motor, but represent a higher order of neural pro cessing. Of the large number of studies on such systems, analyses of startle circuits compose a major portion, and have been carried out on systems found throughout the animal kingdom. Startle has been an im portant model because of the reliability of the behavioral act for laboratory study and the accessibility of the underlying neural circuitry. However, probably because of the breadth of the subject, this material has never been reviewed in a comprehensive way that presents the elements com mon to startle circuits in the different animal systems in which they occur. This book presents a diversity of approaches based on a broad back ground of animal groups ranging from the earliest nervous systems in cnidarians to the most recently evolved and advanced in mammals. The behaviors themselves are all short latency, fast motor acts, when consid ered on the time scale of the organism, and involve avoidance or evasion, although in some cases we do not yet completely understand their natural role. These behaviors occur in response to stimuli that have sudden or unexpected onset."