Compiled with the most sophisticated chromatographic and spectrometric instruments available, this complete and self-contained seven-volume reference provides forensic, toxicology, and clinical laboratories with up-to-date information on 1,600 drugs and drug-related compounds-one of the largest collections of analytical data generated from a single source. Instrumental Data for Drug Analysis contains timely, quality data presented in a large, easily usable format. It is an essential reference in the libraries of all toxicology, analytical chemistry, and forensic specialists and laboratories.

With the addition of this fifth volume, Instrumental Data for Drug Analysis, Second Edition is the definitive work on drug analysis. The complete five-volume set contains over 6,000 spectra on 1,600 drugs and related compounds, incorporating numerous chromatographic and spectrometric instruments, and includes a total of 13 appendices. Professionals working in forensic, crime, clinical, and toxicological laboratories will find this volume to be an invaluable reference that they will rely on daily. Among volume five's features are: monographs for each compound - including chemical titles, molecular formula and weights, and mass spectra data on over 250 drug derivatives.

Compiled with the most sophisticated chromatographic and spectrometric instruments available, this complete and self-contained seven-volume reference provides forensic, toxicology, and clinical laboratories with up-to-date information on 1,600 drugs and drug-related compounds-one of the largest collections of analytical data generated from a single source. Instrumental Data for Drug Analysis contains timely, quality data presented in a large, easily usable format. It is an essential reference in the libraries of all toxicology, analytical chemistry, and forensic specialists and laboratories.

This book focuses on the role of the nervous system in echinoderm regeneration taking into account the neurotrophic control of regeneration and the specific involvement of neurally derived factors in regulating cellular phenomena such as proliferation, migration and differentiation.

This classic book will meet the needs of food and agricultural industries in both their research and business needs. Learn the fundamentals of applying statistics to the business and research needs in the food and agricultural industries. Statistical Methods for Food and Agriculture is a practical, hands-on resource that explores how statistics, a relatively recent development for science and business, facilitates the decision-making process. The range of techniques and applications explained and demonstrated in each of the four major sections of this volume provides a substantial course of study for those in business, government, and universities dealing with food, agriculture, and economics. Part I provides an introduction to the uses of statistics today, including basic concepts and definitions. Part II examines the statistical needs of the food researcher. The emphasis is on design of planned experiments, the analysis of data generated by planned experiments, and decision making in a research environment. Part III deals with statistical procedures that have a wide range of uses for the researcher and business analyst in both business and research situations. Part IV focuses on those statistical methods that have primarily a business application. This important volume is sufficiently detailed to enable the reader to learn and develop without outside assistance. References lead to more detailed presentations for those desiring additional specialized information, and helpful exercises at the end of each chapter permit the book?s use as a textbook as well.

This book is a concise and practical tool recommended for quick revision, rote memorization, and self-assessment of knowledge in forensic psychiatry. It is useful for forensic psychiatrists, psychologists, social workers, criminologists, mental health law attorneys and general psychiatrists.

Molecular biologists are performing increasingly large and complicated experiments, but often have little background in data analysis. The book is devoted to teaching the statistical and computational techniques molecular biologists need to analyze their data. It explains the big-picture concepts in data analysis using a wide variety of real-world molecular biological examples such as eQTLs, ortholog identification, motif finding, inference of population structure, protein fold prediction and many more. The book takes a pragmatic approach, focusing on techniques that are based on elegant mathematics yet are the simplest to explain to scientists with little background in computers and statistics.

Analyze Repeated Measures Studies Using Bayesian Techniques Going beyond standard non-Bayesian books, Bayesian Methods for Repeated Measures presents the main ideas for the analysis of repeated measures and associated designs from a Bayesian viewpoint. It describes many inferential methods for analyzing repeated measures in various scientific areas, especially biostatistics. The author takes a practical approach to the analysis of repeated measures. He bases all the computing and analysis on the WinBUGS package, which provides readers with a platform that efficiently uses prior information. The book includes the WinBUGS code needed to implement posterior analysis and offers the code for download online. Accessible to both graduate students in statistics and consulting statisticians, the book introduces Bayesian regression techniques, preliminary concepts and techniques fundamental to the analysis of repeated measures, and the most important topic for repeated measures studies: linear models. It presents an in-depth explanation of estimating the mean profile for repeated measures studies, discusses choosing and estimating the covariance structure of the response, and expands the representation of a repeated measure to general mixed linear models. The author also explains the Bayesian analysis of categorical response data in a repeated measures study, Bayesian analysis for repeated measures when the mean profile is nonlinear, and a Bayesian approach to missing values in the response variable.

Advances in pharmacogenomics and proteomics, along with the introduction of recombinant DNA technology, have expanded the applications of pharmacology to encompass a range of disciplines. Biomedical researchers, protein specialists, and molecular biologists are all involved in the development and delivery of novel drugs. Therefore, students in a variety of life sciences now require grounding in pharmacology. Adding much new material, Introduction to Pharmacology, Third Edition familiarizes students with the curative action of specific drugs, along with current research and the multifaceted role of pharmacology in society. New to the third edition Chapters on smooth muscle pharmacology covering gastrointestinal and pulmonary pharmacology Pharmacology advances at the molecular level The historical background of the Watson Crick model of DNA Cutting edge topics such as RNA interference and dopamine signaling The text begins with a discussion on the absorption, distribution, metabolism, and elimination of drugs. Much emphasis is placed on pharmacokinetic aspects: how drugs produce an effect and the quantification of these effects for comparative purposes. Also the text describes substance abuse pharmacology and the evolution of drug laws. Several chapters deal with the development of drugs and challenges faced in drug discovery. Identifying both the therapeutic and toxicological aspects of drug use, Introduction to Pharmacology employs contemporary examples to help students become familiar with drug development and treatment, as well as possible adverse affects, and the impact of drug research and use on society today and into the future.

An understanding of statistical principles and methods is essential for any scientist but is particularly important for those in the life sciences. The field biologist faces very particular problems and challenges with statistics as "real life" situations such as collecting insects with a sweep net or counting seagulls on a cliff face can hardly be expected to be as reliable or controllable as a laboratory-based experiment. Acknowledging the peculiarities of field-based data and its interpretation, Practical Statistics for Field Biology introduces readers to the principles and methods of statistical analysis allowing them to understand research reports in journals, decide on the most appropriate statistical tests for their own problems and finally to analyse and present their findings. To enhance the usefulness of this book, the new edition incorporates the more advanced method of multivariate analysis, introducing the nature of multivariate problems and describing the techniques of principal components analysis, cluster analysis and discriminant analysis which are all applied to biological examples. An appendix detailing the statistical computing packages available has also been included. Practical Statistics for Field biology will be of interest to undergraduates studying ecology, biology, and earth and environmental sciences. In addition, it will be useful for postgraduates who are not familiar with the application of multivariate techniques and practising field biologists working in these areas.

Review of the First Edition

"In summary, Practical Statistics for Field Biology is an excellent introductory text for first and second year undergraduate courses in biology." Trends in Ecology & Evolution

What the lecturers said about the First Edition: "An excellent introductory guide to statistics." "Applicable examples in an understandable text."

A "how to" guide for applying statistical methods to biomarker data analysis Presenting a solid foundation for the statistical methods that are used to analyze biomarker data, Analysis of Biomarker Data: A Practical Guide features preferred techniques for biomarker validation. The authors provide descriptions of select elementary statistical methods that are traditionally used to analyze biomarker data with a focus on the proper application of each method, including necessary assumptions, software recommendations, and proper interpretation of computer output. In addition, the book discusses frequently encountered challenges in analyzing biomarker data and how to deal with them, methods for the quality assessment of biomarkers, and biomarker study designs. Covering a broad range of statistical methods that have been used to analyze biomarker data in published research studies, Analysis of Biomarker Data: A Practical Guide also features: A greater emphasis on the application of methods as opposed to the underlying statistical and mathematical theory The use of SAS(R), R, and other software throughout to illustrate the presented calculations for each example Numerous exercises based on real-world data as well as solutions to the problems to aid in reader comprehension The principles of good research study design and the methods for assessing the quality of a newly proposed biomarker A companion website that includes a software appendix with multiple types of software and complete data sets from the book's examples Analysis of Biomarker Data: A Practical Guide is an ideal upper-undergraduate and graduate-level textbook for courses in the biological or environmental sciences. An excellent reference for statisticians who routinely analyze and interpret biomarker data, the book is also useful for researchers who wish to perform their own analyses of biomarker data, such as toxicologists, pharmacologists, epidemiologists, environmental and clinical laboratory scientists, and other professionals in the health and environmental sciences.

Provides a unique tableau of the funeral director's world. As such, it is a contribution to the growing literature on death and dying. Like the study of deviance which aids understanding of the norms of society, the sociology of death uncovers many insights into the very structures and patterns which shape life.

Authoritative resource presenting techniques and technologies to sustainably neutralize environmental contamination in aquatic plants, microorganisms, and more Two thirds of the Earth is covered with aquatic habitats that play a key role in stabilizing the global environment and providing a wide variety of services to increasing human needs. Nevertheless, anthropogenic activities are rapidly destroying the quality of both fresh and marine waters globally, due to excessive use of chemicals, fertilizers and pollution from suburban and industrial areas eventually making their way into the aquatic world. Aquatic Contamination: Tolerance and Bioremediation presents the broader spectrum of biological applicability of microbes with better understanding of cellular mechanisms for remediation of aquatic contaminants. The book also focuses on practices involved in molecular and genetic approaches, necessary to achieve targets of bioremediation and phytoremediation to solve global water contamination problems. Such approaches pave the way for the utilization of biological assets to design new, efficient, and environmentally sound remediation strategies by inculcating genomic techniques at cellular and molecular levels with model assessment. Aquatic Contamination provides a comprehensive background for readers interested in all perspectives of the contamination of aquatic environs. It covers various research aspects which are being carried out globally to understand simulation models in the assessment of xenobiotics, role of genomics, transgenic plants, and microbial enzymes for degradation and removal of toxic substances in aquatic environs. Key features include: Extensive coverage of interactions between plant, metals and microbes including the influence of biotic and abiotic factors Comprehensive discussion of the details of molecular mechanisms from assimilation to detoxification levels Exploration of the enzymatic approaches of potential plants acting as hyper-accumulators for contaminants in aquatic environs Details of sustainable tools such as transgenic plants for the manipulation of important functional microbial genes to achieve higher certainty of bioremediation Details of advances in tools and models like micro-arrays and simulation models for the complete assessment of xenobiotic compounds from cellular to degradation hierarchies Aquatic Contamination: Tolerance and Bioremediation will be substantially helpful to environmentalists, microbiologists, biotechnologists and scientists, providing essential information on various modern technologies for the remediation of contaminants in aquatic ecosystems.

Well-illustrated throughout and with in-depth analyses, Nutrition, Diet Therapy, and the Liver provides a holistic understanding of the causative elements that precipitate liver disease and the nutritional factors and regimens that reverse deteriorating hepatic function. This up-to-date resource also incorporates emerging fields of science and significant discoveries. With contributions from leading experts of international repute in their respective fields, the book first emphasizes the important role nutrition plays not only in the prevention of liver disease but also in the reversal of liver dysfunction. The second section covers various aspects of alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) as well as the consequent steatohepatitis that encompasses the whole spectrum of triglyceride accumulation, inflammation, fibrosis, and end-stage cirrhosis of the liver. The book then focuses on the mounting evidence in support of alcohol abuse, hepatitis viruses, and immune diseases as key predisposing factors in the incidence of hepatocellular carcinomas. The final section evaluates the importance of nutrition in the treatment of liver diseases in infants versus adults, including recovery after liver transplantation.

During the past decade since the first edition of this practical work was published, global prevalence of obesity has increased by epic proportions, and physical fitness levels have continued to decline. Nutrition, Physical Activity, and Health in Early Life, Second Edition analyzes cutting-edge longitudinal and cross-sectional data on morphological, nutritional, and functional characteristics related to environmental factors to assess how the lifestyle choices we make when we're young deeply impact overall health and wellness throughout our lives. Includes Step-by-Step Nutrition and Exercise Plans Extensively revised and updated, this definitive second edition synthesizes new, original research findings related to anthropometric and body composition data, dietary intake, cardiorespiratory function, motor and psychomotor skills, muscle strength, and biochemical and physiological parameters of preschool-age children. The book supplies ready-to-implement nutrition and exercise plans that are appropriate for children in this age group. Almost tripling the number of references, the text includes new chapters that address the role of genetic factors in addition to prevention techniques, consequences, and treatment of obesity. It also compares body mass index, body composition, and the shifts of adiposity rebound on an international scale. Nutrition, Physical Activity, and Health in Early Life, Second Edition emphasizes that to preserve a high-quality of life no matter your age, it is crucial that a foundation of healthy nutrition and optimal physical activity, which increases the level of physical fitness, be cemented early on. In effect, this book illustrates why early prevention always trumps a cure.

The Visible Human Project is a critical investigation of the spectacular, three-dimensional recordings of real human bodies - dissected, photographed and converted into visual data files - made by the US National Library of Medicine in Baltimore. Catherine Waldby uses new ideas from cultural studies, science studies and social studies of the computer to situate the Visible Human Project in its historical and cultural context, and to consider the meanings such an object has within a computerised culture.
In this fascinating and important book, Catherine Waldby explores how advances in medical technologies have changed the way we view and study the human body, and places the VHP within the history of technologies such as the X-ray and CT-scan, which allow us to view the human interior.
Bringing together medical conceptions of the human body with theories of visual culture from Foucault to Donna Haraway, Waldby links the VHP to a range of other biomedical projects, such as the Human Genome Project and cloning, which approach living bodies as data sources. She argues that the VHP is an example of the increasingly blurred distinction between `living' and 'dead' human bodies, as the bodies it uses are digitally preserved as a resource for living bodies, and considers how computer-based biotechnologies affect both medical and non-medical meanings of the body's life and death, its location and its limits.

eBook available with sample pages: HB:0415174058

The Visible Human Project is a critical investigation of the spectacular, three-dimensional recordings of real human bodies - dissected, photographed and converted into visual data files - made by the US National Library of Medicine in Baltimore. Catherine Waldby uses new ideas from cultural studies, science studies and social studies of the computer to situate the Visible Human Project in its historical and cultural context, and to consider the meanings such an object has within a computerised culture.
In this fascinating and important book, Catherine Waldby explores how advances in medical technologies have changed the way we view and study the human body, and places the VHP within the history of technologies such as the X-ray and CT-scan, which allow us to view the human interior.
Bringing together medical conceptions of the human body with theories of visual culture from Foucault to Donna Haraway, Waldby links the VHP to a range of other biomedical projects, such as the Human Genome Project and cloning, which approach living bodies as data sources. She argues that the VHP is an example of the increasingly blurred distinction between `living' and 'dead' human bodies, as the bodies it uses are digitally preserved as a resource for living bodies, and considers how computer-based biotechnologies affect both medical and non-medical meanings of the body's life and death, its location and its limits.

Sustained-Release Injectable Products focuses on the development process for sustained-release versions of drugs and delivery systems and administration routes. From the rationale and basic product development principles to regulatory issues and the approval process, expert contributions address virtually every aspect. They bring together common threads that apply to any sustained-release formulation, such as scale-up, safety, biocompatibility, analytical challenges, and quality assurance.

First responders confronted by forensic cases are forced to consider the competing concerns of administering proper medical treatment while at the same time safeguarding vital evidence. Forensic Science in Healthcare: Caring for Patients, Preserving the Evidence presents precise on-scene protocol designed to ensure that the actions of the response team provide the necessary care and yet maintain the integrity of the evidence for legal purposes. Following an introduction to forensics, the book explains how to recognize and identify patients with forensic issues, offers guidelines on proper documentation, and provides tips on forensic photography and capturing critical images. It reviews basic principles of evidence collection before moving into specific case scenarios, including domestic violence, sexual assault, child and elder abuse, youth violence, and death investigation. The book also examines occupational concerns for forensic personnel as well as legal issues such as testifying in depositions and in court. Enhanced with photographs, illustrations, templates for documentation, and case-specific recommendations, this one-stop reference provides first responders with practical understanding of the steps that should be followed to ensure not only patient protection but evidence preservation.

Succeed in your biology course with this updated Sixth Edition of BIOLOGY TODAY AND TOMORROW WITHOUT PHYSIOLOGY. Packed with real-world applications, the book offers chunked content in a clear, straightforward writing style, beautiful art and a variety of in-text learning tools. The accompanying MindTap for Biology includes multimedia instruction, assessments, videos, personalized study tools and more. With this easy-to-read, engaging text, you'll learn about biology from the perspective of issues relevant to your daily life.

Protecting Watershed Areas: Case of the Panama Canal provides foresters, hydrologists, and park managers with a case study of the Panama Canal watershed area to help you make the most of your efforts in protecting ecological areas. Through this unique book, you will discover how the Carter-Torrijos treaty that will return the Panama Canal to the Republic of Panama on December 31, 1999 will affect the 2.6 million inhabitants of that area as well as this complex ecosystem. This valuable book includes a focus on both technical and biological observations in the field as well as library research to help you make the most of book learning and field research in your endeavors to protect forest reserves and other protected areas. Protecting Watershed Areas offers you insight into the Panama Canal area through informal interviews, key informants, field data, and research that focuses on both the technical and biological aspects of environmental management, such as agroforestry and reforestation, of environmental management and on policy and institutional dimensions of management to provide you with a unique perspective of the dynamics of this area. The Panama canal watershed area is one of the world?s most complex managed ecosystems and through this insightful volume, you will find new ways to deal with the myriad of problems you may encounter in ecosystem management, such as: realizing that single resource management is no longer adequate and taking a more holistic approach to management, such as taking into consideration whole ecosystems or watersheds will enable you to fully protect the area you are trying to serve discovering how the trend of privitization and nongovernmental ownership of protected areas impacts the job of managing our precious national resources understanding that for effective and stable protected area management to occur, you must have a clear understanding of the historical and social context that has shaped the particular circumstances of each site recognizing larger national and international factors in order to control the often devastating effects of tourism on protected areas creating clear directives and priorities before developing conservation programs to make program implementation easierInformative and insightful, Protecting Watershed Areas examines the most current ideas in protected areas management through a unique case study of the Panama Canal. This essential book provides you with several answers to the challenges facing Panama that you can apply to forest reserve and other protected areas programs around the globe due to the paramount importance of developing sustainable land-use systems. With Protecting Watershed Areas, you will discover how to effectively balance securing goods and services from a region, such as farming and tourism without threatening the overall integrity of the ecological systems and meeting human needs and values.

Explores a Range of Multiscale Biomechanics/Mechanobiology Concepts Cell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forces in cell-matrix interactions. Providing material in each chapter that builds on the previous chapters, it effectively integrates length scales and contains, for each length scale, key experimental observations and corresponding quantitative theoretical models. Summarizes the Three Hierarchical Levels of Cell Mechanics The book contains 14 chapters and is organized into three sections. The first section focuses on the molecular level, the second section details mechanics at the cellular level, and the third section explores cellular mechanics at the tissue level. The authors offer a thorough description of the roles of mechanical forces in cell and tissue biology, and include specific examples. They incorporate descriptions of associated theoretical models, and provide the data and modeling framework needed for a multi-scale analysis. In addition, they highlight the pioneering studies in cell-matrix mechanics by Albert K. Harris. The topics covered include: The passive and active mechanical properties of cytoskeletal polymers and associated motor proteins along with the behavior of polymer networks The mechanical properties of the cell membrane, with an emphasis on membrane protein activation caused by membrane forces The hierarchical organization of collagen fibrils, revealing that a delicate balance exists between specific and nonspecific interactions to result in a structure with semicrystalline order as well as loose associations The roles of matrix mechanical properties on cell adhesion and function along with different mechanical mechanisms of cell-cell interactions The effects of mechanical loading on cell cytoskeletal remodeling, summarizing various modeling approaches that explain possible mechanisms regulating the alignment of actin stress fibers in response to stretching The mechanical testing of cell-populated collagen matrices, along with theory relating the passive and active mechanical properties of the engineered tissues Cell migration behavior in 3-D matrices and in collective cell motility The role of mechanics in cartilage development The roles of both cellular and external forces on tissue morphogenesis The roles of mechanical forces on tumor growth and cancer metastasis Cell and Matrix Mechanics succinctly and systematically explains the roles of mechanical forces in cell-matrix biology. Practitioners and researchers in engineering and physics, as well as graduate students in biomedical engineering and mechanical engineering related to mechanobiology, can benefit from this work.

An insider's view on bringing extinct species back to life Could extinct species, like mammoths and passenger pigeons, be brought back to life? In How to Clone a Mammoth, Beth Shapiro, an evolutionary biologist and pioneer in ancient DNA research, addresses this intriguing question by walking readers through the astonishing and controversial process of de-extinction. From deciding which species should be restored to anticipating how revived populations might be overseen in the wild, Shapiro vividly explores the extraordinary cutting-edge science that is being used to resurrect the past. Considering de-extinction's practical benefits and ethical challenges, Shapiro argues that the overarching goal should be the revitalization and stabilization of contemporary ecosystems. Looking at the very real and compelling science behind an idea once seen as science fiction, How to Clone a Mammoth demonstrates how de-extinction will redefine conservation's future.

Covers new trace evidence techniques and expanding areas of analysis, along with key theory and applications Developed around the need for updated information in the disciplines of trace evidence the Handbook of Trace Evidence Analysis focuses on the increasing awareness and need for validation, modern methods for addressing and controlling contamination, the shift towards incorporating statistical analyses into the interpretation phase and cutting edge research into new forensic science methods and their application. Beginning with an overview of the topic and discussing the important role that information derived from trace materials can provide during investigations, the book then presents chapters on key techniques. The first being the critical nature of microscopy, and the methods employed for the recognition, collection, and preservation of trace evidence. Subsequent chapters review the core disciplines of trace evidence examination: paints and polymers, hairs, fibers and textiles and glass. Each chapter contains in-depth discussions on the origin of the materials involved, including any natural or synthetic processes involved in their production, the nuances involved in their detection, and the methods of analysis that are used to extract valuable information from samples. In addition, suggested workflows in method and testing selections, as well as addressing specific scientific challenges as well as the limitations of knowledge on the transfer, persistence and background abundance of trace materials are discussed. The book ends by examining the interpretation of trace evidence findings from a historical perspective and examining the methods that are currently being developed. Provides an in-depth introduction to the general area of trace evidence and discusses current and new techniques Consolidates trace evidence and materials categories of testing into one reference series Offers a detailed focus on technical approaches and guidelines to trace evidence Includes analytical schemes/workflows and valuable guides for the interpretation of data and results The Handbook of Trace Evidence will appeal to forensic science academics, students, and practitioners in the trace evidence and materials science disciplines, as well as DNA analysts, toxicologists, forensic anthropologists, crime laboratory managers, criminal justice students and practitioners, and legal professionals. It would also be a valuable resource for every crime laboratory reference library.