In recent years, significant advancements have been made in the management of nutritional deficiency using genome engineering--enriching the nutritional properties of agricultural and horticultural crop plants such as wheat, rice, potatoes, grapes, and bananas. To meet the demands of the rapidly growing world population, researchers are developing a range of new genome engineering tools and strategies, from increasing the nutraceuticals in cereals and fruits, to decreasing the anti-nutrients in crop plants to improve the bioavailability of minerals and vitamins. Genome Engineering for Crop Improvement provides an up-to-date view of the use of genome editing for crop bio-fortification, improved bioavailability of minerals and nutrients, and enhanced hypo-allergenicity and hypo-immunogenicity. This volume examines a diversity of important topics including mineral and nutrient localization, metabolic engineering of carotenoids and flavonoids, genome engineering of zero calorie potatoes and allergen-free grains, engineering for stress resistance in crop plants, and more. Helping readers deepen their knowledge of the application of genome engineering in crop improvement, this book: Presents genetic engineering methods for developing edible oil crops, mineral translocation in grains, increased flavonoids in tomatoes, and cereals with enriched iron bioavailability Describes current genome engineering methods and the distribution of nutritional and mineral composition in important crop plants Offers perspectives on emerging technologies and the future of genome engineering in agriculture Genome Engineering for Crop Improvement is an essential resource for academics, scientists, researchers, agriculturalists, and students of plant molecular biology, system biology, plant biotechnology, and functional genomics.

This is a book about fishermen's reasons for obeying fisheries law. The fish harvesting industry has become subject to state interference to an increasing extent over the past twenty years. As natural resources become scarce and subsequent fisheries regulations abound, the question of law-abidingness is brought to the public agenda. However, there is still little empirical data as regards the dynamics of compliance in this field, and this book aims to meet a demand for in-depth knowledge. The cases studied can be regarded as instances of economies dependent on the harvesting of natural resources for both household and the market, and the study aims to contribute to the building of more adequate theory on the dynamics of compliance in such economies. However, focusing on a specific type of setting seldom constitutes a safe escape route for getting away from more pervasive sociological questions, and it certainly does not in this case. As any attempt to explain social phenomena, this study is faced with the fundamental sociological question of how the acts of individuals can best be understood. The question concerns the interface between the individual and the collectivity - between collective morality and self-interest. It thus deals with classical sociological issues such as the nature and regulatory capacity of group norms and sanctions, and the forms and roles of rationality and strategic action.

This clear, concise Complete Revision & Practice book from CGP is a perfect way to prepare for the Edexcel A A-Level Biology exams - it covers every topic from both years of the course. It's fully up-to-date for the new exam specifications for 2015 and beyond, with straightforward explanations, helpful examples and full-colour diagrams throughout. Practice questions and exam-style questions (with answers) are included for every topic, and the book is rounded off with a section of in-depth advice on Practical Skills. And finally, a free Online Edition of the whole book is included - just use the code printed inside the book to access it on your PC, Mac or tablet!

Analysis of Failure and Survival Data is an essential textbook for graduate-level students of survival analysis and reliability and a valuable reference for practitioners. It focuses on the many techniques that appear in popular software packages, including plotting product-limit survival curves, hazard plots, and probability plots in the context of censored data. The author integrates S-Plus and Minitab output throughout the text, along with a variety of real data sets so readers can see how the theory and methods are applied. He also incorporates exercises in each chapter that provide valuable problem-solving experience.

In addition to all of this, the book also brings to light the most recent linear regression techniques. Most importantly, it includes a definitive account of the Buckley-James method for censored linear regression, found to be the best performing method when a Cox proportional hazards method is not appropriate.

Applying the theories of survival analysis and reliability requires more background and experience than students typically receive at the undergraduate level. Mastering the contents of this book will help prepare students to begin performing research in survival analysis and reliability and provide seasoned practitioners with a deeper understanding of the field.

First volume selling primarily in the United States, push for more global promotion. "non-invasivel" related healing modalities and environmental medicine are both very hot topics. There are not any existing books with this dual focus that have an accompanying successful volume on nutrition and integrative medicine.

Most researchers would be amazed to discover that opinions they have about cherished themes in biology and medicine are biased. Van der Steen and Ho contend that logic and methodology are not well applied in biology and medicine, arguing that the impact of social and moral factors on claims within these two disciplines is underestimated. In response to this situation, Van der Steen and Ho present tools from logic and ethics for assessing existing literature. These tools will help to create sound articles and materials in the life sciences.

After reviewing logic and methodological approaches, broad guidelines are used to place science in a social context. Examples from life sciences illustrate the implementation of logic, methodology, and guidelines in forty-five brief case studies. Each study includes comments on quoted and paraphrased passages from a single article or book. Cross-references facilitate the assimilation of lessons from the text. Students, researchers, and scholars in biology, biomedicine, philosophy, and ethics as applied to the life sciences will find this guide useful in improving their research and writing skills.

Sample Sizes for Clinical Trials, Second Edition is a practical book that assists researchers in their estimation of the sample size for clinical trials. Throughout the book there are detailed worked examples to illustrate both how to do the calculations and how to present them to colleagues or in protocols. The book also highlights some of the pitfalls in calculations as well as the key steps that lead to the final sample size calculation. Features: Comprehensive coverage of sample size calculations, including Normal, binary, ordinal, and survival outcome data Covers superiority, equivalence, non-inferiority, bioequivalence and precision objectives for both parallel group and crossover designs Highlights how trial objectives impact the study design with respect to both the derivation of sample formulae and the size of the study Motivated with examples of real-life clinical trials showing how the calculations can be applied New edition is extended with all chapters revised, some substantially, and four completely new chapters on multiplicity, cluster trials, pilot studies, and single arm trials The book is primarily aimed at researchers and practitioners of clinical trials and biostatistics, and could be used to teach a course on sample size calculations. The importance of a sample size calculation when designing a clinical trial is highlighted in the book. It enables readers to quickly find an appropriate sample size formula, with an associated worked example, complemented by tables to assist in the calculations.

In recent years, systems biology seems to have encountered insurmountable obstacles. Precision medicine faces the problem of integration in disease regulation, despite the establishment of biomarker systems and the continuous discovery of new targeted drugs. Towards Holistic Medicine explores the development of modern medicine and the future medical model in the broader perspective of Chinese and Western medicine, biology, and even the methodological evolution of natural science in recent centuries. The book discusses how modern medicine will move past systems biology and precision medicine and toward holistic medicine.

This book systematically addresses all the major available direct and enabling technologies which have contributed to the revolutionized research and development, thus improvements to existing vaccines. Its target audience is both research and development workers in the field, as well as health-care personnel who use vaccines. It should serve as an invaluable source-book in the vaccine field.

Many athletes suffer health and sports consequences related to inadequate nutrition to meet their sports demands. It often goes unrecognized and untreated if they do not have the stereotypical diagnosis of an “eating disorder.” Highly marketable for those looking to gain an extra edge above the competition by maximizing their health through appropriate nutrition and mental work. The book has background information on the problem and serves as an instruction manual for coaches and parents. Female athletes’ personal narratives are dispersed within the information.

This revised and updated second edition is an accessible companion designed to help science and technology students develop the knowledge, skills and strategies needed to produce clear and coherent academic writing in their university assignments. Using authentic texts to explore the nature of scientific writing, the book covers key areas such as scientific style, effective sentence and paragraph structure, and coherence in texts and arguments. Throughout the book, a range of tasks offers the opportunity to put theory into practice. The explorative tasks allow you to see how language works in a real scientific context, practice and review tasks consolidate learning and help you to develop your own writing skills, and reflective tasks encourage you to think about your own knowledge and experience, and bring this to bear on your own writing journey at university. Key features of the new edition include: * Updated content and additional tasks throughout * New chapters, covering writing in the sciences and writing at university * The introduction of reflective tasks * Up-to-date examples of authentic scientific writing Clear, engaging and easy-to-use, this is an invaluable tool for the busy science or technology student looking to improve their writing and reach their full academic potential.

This fantastic CGP Exam Practice Workbook is the perfect companion for Year 1 & 2 of AQA A-Level Biology. It's packed with ultra-realistic exam questions covering every topic students need to know, including a section of mixed (synoptic) questions. We've added in exam tips throughout to make sure there are no unpleasant surprises in their exams! To round things off there are fully worked answers and mark schemes for every question. For study notes and even more practice don't miss the CGP AQA A-Level Biology Complete Revision & Practice guide (9781789080261).

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The biochemistry/USMLE (R) review you've been waiting for . . . clear, concise, high yield, and clinically relevant INCLUDES AN ONLINE VIDEO LECTURE FOR EVERY CHAPTER! The goal of Fundamentals of Biochemistry: Medical Course & Step 1 Review is to make biochemistry an approachable, clinically relevant subject for your first years of medical school, and, most importantly, when you prepare to take the USMLE (R) Step 1 examination. The authors believe that when biochemistry is put in a clinical context, learning and understanding it becomes much less complicated, as all the pieces of the "puzzle" fall into place. A SELF-CONTAINED, HIGH-YIELD GUIDE UNLIKE ANY OTHER You will find Fundamentals of Biochemistry: Medical Course & Step 1 Review to be a self-contained guide to high-yield biochemistry, with a strong focus on the topics you are most likely to see on the USMLE (R) Step 1 exam. You can select any chapter and find a self-contained summary of the relevant topic. The authors begin with the basics of the cell and DNA, and protein synthesis, then cover the central aspects of metabolism, and finish with nutrition and genetics. EASY-TO-ABSORB CHAPTERS ENHANCED BY COMPANION ONLINE VIDEOS The information is delivered in a simple outline format that pinpoints the high-yield information you need to know. Each chapter is also presented as a lecture, in video format, so you can review the topic in real time and add additional notes as you learn each topic or review them later.

Infrared and Raman Spectroscopy of Biological Materials facilitates a comprehensive and through understanding of the latest developments in vibrational spectroscopy. It contains explains key breakthroughs in the methodologies and techniques for infrared, near-infrared, and Raman spectroscopy. Topics include qualitative and quantitative analysis, biomedical applications, vibrational studies of enzymatic catalysis, and chemometrics.

Despite their importance in terms of employment and income generation, inshore fisheries have been a neglected area of study. The review of the common fisheries policy, especially in the light of the need to re-examine the derogation which reserves access to the inshore zone to coastal state vessels, provides an opportunity to redress the balance. With contributions from leading authorities on fisheries management, the book takes an in-depth look at seven European countries, examining the basis for the definition of inshore fisheries, evaluating their status, and describing the salient characteristics of their management. The national studies form the basis for cross-cultural analyses of the social organisation, cultural norms, economic objectives, and institutional structures of inshore fisheries in Europe. Finally, a number of key issues relating to the future of inshore fisheries management in a more integrated approach are examined. Overall the volume reaffirms the invaluable role played by inshore fisheries in the local and regional economies of Europe's complex coastline.

Series Information:
Studies in Philosophy

Topical and transdermal drug delivery systems (TDDs) have several advantages over traditional drug delivery methods, as they can be less invasive, more sanitary, more cost-effective, and may result in better patient compliance. TDDs play a significant role in therapeutics with a variety of preparations and approaches designed by expert formulation scientists. This volume integrates a wide variety of case studies, research, and theories to reveal their diversity and capture the novel approaches of transdermal and topical drug delivery employed by developers and content experts in the field. It provides an abundance of important information and state-of-the-art research on topical and transdermal drug delivery systems and addresses the basics of drug delivery systems, strategies to enhance permeation across membranes, and formulation and evaluation of diverse dosage forms. The volume presents an evaluation of the pros and cons of conventional drug delivery systems against TDDs and discusses the nuances of micro- and nano-systems in TDDs. The extraordinary packages of nano systems (vesicular systems, polymeric nanoparticles, nanoemulsion and dendrimers) are broadly discussed, and their applications are reviewed through a transdermal route. The book looks at TDDs and the main nanoparticles used in skin diseases and lesions of the aging, such as psoriasis, vitiligo, cancer, lesions of the aging and others. Chapters also discuss polymeric micelles in topical and transdermal delivery; microneedles; emulsion, nanoemulsion and microemulsion; TDDs in pulmonary drug delivery systems; nanoencapsulated nasal drug delivery systems; skin sensitivity and irritation testing for transposing transdermal drug delivery systems; and regulatory aspects of drug development for dermal products. Topical and Transdermal Drug Delivery Systems: Applications and Prospects will be a valuable resource for pharmaceutical scientists and researchers, industry professionals, and academicians and students of the pharmaceutical and biomedical sciences.

This book presents a general introduction to the measurement of the biological effects of pollution on the marine environment.

This updated book reflects improvements in a variety of techniques used to study the aptamer field. Beginning with a section on selection procedures, the volume continues with methods to characterize aptamers' interaction and structural properties by biophysical approaches, as well as a variety of applications that have been adapted to the aptamer compound class. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Nucleic Acid Aptamers: Selection, Characterization, and Application, Second Edition serves as an ideal guide for researchers aiming to further our understanding of aptamer biology and more.

The current edition of Video Microscopy has been totally revised to reflect the advances in the tools for electronic imaging, processing, recording, and analysis, as well as applications that are being made in video microscopy and related modes of electronic imaging. The less spiral organization of the revised edition reflects an audience expected to be more experi enced in video and computer image processing than in the earlier days when coupling of video equipment and computers to the light microscope was still considered to be a novelty. Nevertheless, we have emphasi2;ed the how-tos, as well as the fundamental principles, involved in imaging and processing ih the light microscope, the human visual system, video and related electronic imaging, and the digital image processor in the hope that the reader will develop enough understanding, not only to apply rationally what is available, but also to contribute actively to the development of this evolving field. In the text, the terms appearing in the Glossary are printed in bold type, generally, at first appearance. Italics are used for emphasis.

This volume on the ecology of Mauritanian coastal waters and in particular the Banc d'Arguin, explores the functioning of this remarkable coastal wetland. Major questions concern the interaction between the Banc d'Arguin ecosystem on the one hand, and the adjoining systems of the open ocean with its intensive upwelling phenomena and the Sahara desert on the other.