Exam Board: Edexcel Level: A level Subject: Science / Biology First teaching: September 2015 First exams: June 2017 Revise smart and save! Designed for hassle-free classroom and independent study, our Revision Guides are designed to complement the Student Books with a range of specially designed features such as: One-topic-per-page format Worked examples with exemplar answers 'Now Try This' practice questions Knowledge checks and skills checks Includes FREE online edition! With a one-to-one page correspondence between this Revision Guide and the companion Edexcel AS/A level Biology Revision Workbook, the hugely popular REVISE series offers the best value available for A level students.

This detailed volume spotlights methods to investigate a variety of virus-host interactions in humans, other mammals, fish, or insects. It explores viruses such as white spot syndrome virus (WSSV), honeybee viruses, Nipah virus, EBV, SVCV, HSV-1, HIV-1, A H1N1, and SARS-CoV-2, as well as applications of techniques such as qPCR, serum antibody responses, 4C analysis, cell membrane fusion, biosensors, computational modelling, quantitative proteomics, and other genetic tools to decipher those viral infections and interactions. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Virus-Host Interactions: Methods and Protocols serves as a valuable resource for researchers both in academia and in the biosciences industry who are engaged in the search for a better understanding of threatening virus-hosts interactions, virus detection, their characterization, and ultimately their taming and control.

Kweken van bollen in kamer en kas' is the original edition in Dutch of the reference handbook for growing bulbs in a room and greenhouse. Originally published in 1999.

This handbook and ready reference presents a combination of statistical, information-theoretic, and data analysis methods to meet the challenge of designing empirical models involving molecular descriptors within bioinformatics. The topics range from investigating information processing in chemical and biological networks to studying statistical and information-theoretic techniques for analyzing chemical structures to employing data analysis and machine learning techniques for QSAR/QSPR.
The high-profile international author and editor team ensures excellent coverage of the topic, making this a must-have for everyone working in chemoinformatics and structure-oriented drug design.

Doubled haploid technology is an important tool for plant breeding. It allows for significant time reduction in the achievement of homozygous breeding lines of value in crop improvement.

This volume provides an excellent overview of haploid induction and the application of doubled haploids. The authors emphasize advances made in the understanding of microspore embryogenesis, but treat also advances in gynogenesis and the manipulation of parthenogenetic haploid development.

The text contains a thorough discussion of the application of haploidy to the improvement of a number of species from various families, including Brassicaceae, Poaceae, and Solanaceae. The various methods applicable to these species are described in detail. Each chapter contains critical evaluation of the scientific literature and an extensive list of references. This volume is ideally suited for plant breeders, geneticists, and plant cell biologists.

The present monograph analyses the FitzHugh-Nagumo (F-N) model Le., the Cauchy problem for some generalized Van der Pol equation depending on three real parameters a, band c. This model, given in (1. 1. 17), governs the initiation of the cardiac impulse. The presence of the three parameters leads to a large variety of dy namics, each of them responsible for a specific functioning of the heart. For physiologists it is highly desirable to have aglobai view of all possible qualitatively distinct responses of the F-N model for all values of the pa rameters. This reduces to the knowledge of the global bifurcation diagram. So far, only a few partial results appeared and they were spread through out the literature. Our work provides a more or less complete theoretical and numerical investigation of the complex phase dynamics and bifurca tions associated with the F-N dynamical system. This study includes the static and dynamic bifurcations generated by the variation of a, band c and the corresponding oscillations, of special interest for applications. It enables one to predict all possible types of initiations of heart beats and the mechanism of transformation of some types of oscillations into others by following the dynamics along transient phase space trajectories. Of course, all these results hold for the F-N model. The global phase space picture enables one to determine the domain of validity of this model."

The main objective of this book is to systematically describe the basic principles of the most widely used techniques for the analysis of physical, structural, and compositional properties of solids with a spatial resolution of approxi mately 1 m or less. Many books and reviews on a wide variety of microanalysis techniques have appeared in recent years, and the purpose of this book is not to replace them. Rather, the motivation for combining the descriptions of various mi croanalysis techniques in one comprehensive volume is the need for a reference source to help identify microanalysis techniques, and their capabilities, for obtaining particular information on solid-state materials. In principle, there are several possible ways to group the various micro analysis techniques. They can be distinguished by the means of excitation, or the emitted species, or whether they are surface or bulk-sensitive techniques, or on the basis of the information obtained. We have chosen to group them according to the means of excitation. Thus, the major parts of the book are: Electron Beam Techniques, Ion Beam Techniques, Photon Beam Techniques, Acoustic Wave Excitation, and Tunneling of Electrons and Scanning Probe Microscopies. We hope that this book will be useful to students (final year undergrad uates and graduates) and researchers, such as physicists, material scientists, electrical engineers, and chemists, working in a wide variety of fields in solid state sciences."

Singularities in Fluids, Plasmas and Optics, which contains the proceedings of a NATO Workshop held in Heraklion, Greece, in July 1992, provides a survey of the state of the art in the analysis and computation of singularities in physical problems drawn from fluid mechanics, plasma physics and nonlinear optics. The singularities include curvature singularities on fluid interfaces, the onset of turbulence in 3-D inviscid flows, focusing singularities for laser beams, and magnetic reconnection. The highlights of the book include the nonlinear Schr dinger equation for describing laser beam focusing, the method of complex variables for the analysis and computation of singularities on fluid interfaces, and studies of singularities for the 3-D Euler equations. The book is suitable for graduate students and researchers in these areas.

Richard Owen (1804-92) was, after Darwin, the most important figure in Victorian natural history. He was, for most of the six decades of his career, Britain's foremost comparative anatomist and vertebrate palaeontologist. Leader of the nineteenth-century museum movement, he founded London's monumental Natural History Museum, wrote and published copiously and won every professional honour. Positioned at the cutting edge of Victorian science, his work attracted enormous general interest, and he himself came to symbolise 'natural history' in the public mind. His company was sought by royalty (Prince Albert), prime ministers (especially Sir Robert Peel), and by contemporary literati such as Charles Dickens. Owen was, however, a controversial figure whose disagreements with colleagues developed into epic power struggles, the most notorious of which were with Darwin and Huxley. As the most renowned opponent of natural selection, Owen was type-cast as a Cuvierian creationist and became the bete noire of the Darwinian evolution debate. In this comprehensive intellectual and scientific biography, Nicolaas Rupke argues that Owen was no simple-minded anti-evolutionist and, moreover, should be freed from the distortion of the evolution dispute that was only a minor part of his work, yet has come to dominate his memory. Using the museum movement as the primary context of explanation, Rupke throws new light on a wide area of Owen's activities. He reveals the central division in Owen's scientific oeuvre between the functionalism of Oxbridge natural theology and the transcendentalism of German nature philosophy. This epistemological duality confused and puzzled his contemporaries as well as laterhistorians. But as Rupke convincingly demonstrates, it was a fundamental extension of the intellectual and political manoeuvering for control of Victorian cultural institutions, and an inextricable part of the rise to public authority of the most articulate proponents of the scientific study of nature.

The intestinal protozoan Giardia was first described over 300 years ago in 1681 by Leeuwenhoek, from his own stools. In his description of Giardia, he noted the size, movement, and morphology of the organism, and associated its presence with the diarrheic nature of his stools and his dietary habits. This truly remarkable account contains the first description of Giardia in morphologic, pathogenic, and epidemiologic terms. Our knowledge of the organisms in the genus Giardia has advanced tremendously in the past two decades. With the advent of new tech nologies, including techniques in electron microscopy, biochemistry, immunochemistry, tissue culture, and physiology, a tidal wave of information has appeared on the organization and function of this parasitic protozoan and its interaction with its host. The purpose of this book is to celebrate the tricentennial discovery of Giardia by Leeuwenhoek by presenting the above-mentioned advances in our knowledge of Giardia and giardiasis. In the first section of this book, the dominant theme is the biology of the organism and the correlation of structure-function relationships."

In recent years, significant advancements have been made in the management of nutritional deficiency using genome engineering--enriching the nutritional properties of agricultural and horticultural crop plants such as wheat, rice, potatoes, grapes, and bananas. To meet the demands of the rapidly growing world population, researchers are developing a range of new genome engineering tools and strategies, from increasing the nutraceuticals in cereals and fruits, to decreasing the anti-nutrients in crop plants to improve the bioavailability of minerals and vitamins. Genome Engineering for Crop Improvement provides an up-to-date view of the use of genome editing for crop bio-fortification, improved bioavailability of minerals and nutrients, and enhanced hypo-allergenicity and hypo-immunogenicity. This volume examines a diversity of important topics including mineral and nutrient localization, metabolic engineering of carotenoids and flavonoids, genome engineering of zero calorie potatoes and allergen-free grains, engineering for stress resistance in crop plants, and more. Helping readers deepen their knowledge of the application of genome engineering in crop improvement, this book: Presents genetic engineering methods for developing edible oil crops, mineral translocation in grains, increased flavonoids in tomatoes, and cereals with enriched iron bioavailability Describes current genome engineering methods and the distribution of nutritional and mineral composition in important crop plants Offers perspectives on emerging technologies and the future of genome engineering in agriculture Genome Engineering for Crop Improvement is an essential resource for academics, scientists, researchers, agriculturalists, and students of plant molecular biology, system biology, plant biotechnology, and functional genomics.

A new and innovative account of British sociology's intellectual origins that uses previously unknown archival resources to show how the field's forgotten roots in a late nineteenth and early twentieth-century debate about biology can help us understand both its subsequent development and future potential.

Rapid regeneration of city areas has placed the quality of urban design high on public and policy agendas worldwide. This work examines the achievement of quality in the urban environment, in a planning context. Tracing urban design from its roots, the authors draw on both historical and current practices to examine the key physical, political and economic forces at play and the social pressures and impacts brought about by both failures and achievements in urban design. This illustrated critique of towns and cities draws on examples from across Western Europe, South Africa and USA to examine both public and private sector development practices, controls and fiscal policies within a diverse range of localities. The authors indicate the need for a reinstitution of region-provincial approaches, for closer co-ordination bewteen sectors, and revised fiscal policies in planning and development in order to enhance the quality of urban social experience and environments.

The maths needed to succeed in A Level Science is harder now than ever before. Suitable for all awarding bodies, this practical handbook addresses all of the maths skills needed for A Level Biology specifications. Worked examples, practice questions, 'remember points' and 'stretch yourself' questions give students the key knowledge and then the opportunity to practise and build confidence.

This updated book reflects improvements in a variety of techniques used to study the aptamer field. Beginning with a section on selection procedures, the volume continues with methods to characterize aptamers' interaction and structural properties by biophysical approaches, as well as a variety of applications that have been adapted to the aptamer compound class. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Nucleic Acid Aptamers: Selection, Characterization, and Application, Second Edition serves as an ideal guide for researchers aiming to further our understanding of aptamer biology and more.

Carefully delineating each step in the formation of the lung, Lung Growth and Development examines prenatal and postnatal lung development...the regulation of surfactant protein gene expression and models for the analysis of epithelial gene transcription and function...cellular differentiation and the role of mesenchymal cells...airway gland growth and differentiation...growth regulation in the tracheobronchial epithelium and mucociliary differentiation...embryonic precursors of the pulmonary nervous system and the development of lung innervation...Clara cells, airway smooth muscle development, cell interactions in vessel formation, and the surfactant system...respiratory distress syndrome, bronchopulmonary dysplasia, and compensatory lung growth...and more. Written by over 30 international experts, Lung Growth and Development is a practical guide for pulmonologists and pulmonary disease specialists, physiologists, molecular and cellular biologists, pathologists, neonatalogists and pediatricians, anatomists, pathologists, and graduate-level and medical school students in these disciplines.

A myriad of different scenarios await those entering the field of forensic pathology, ranging from gunshot wounds to asphyxiation to explosives to death from addiction. Essential Forensic Pathology: Core Studies and Exercises helps prepare pathologists in training by establishing what they must know about the most common death scenes they will encounter. The book begins by discussing the coaching objectives in medical education and follows with a description of the 15 different rotations of the forensic pathology resident. Using a consistent and concise format, the book describes the facility where the rotation takes place, the necessary skills, the laboratory equipment, and other components of the rotation. The main portion of the book presents forensic pathology essentials in the form of learning objectives-each delineated with a code: "M" for items students must know, and "S" for those they must do. This section begins by discussing the government's role, describes medical examiner and coroner systems, and analyzes the academic discipline of forensic pathology. Next, the book focuses on hands-on elements of forensic pathology, with chapters on scene investigation, identification, and postmortem changes (signs of death). Objectives are also presented for various causes of death, including gunshot wounds, stab wounds, asphyxiation, sex-related death, and death from addiction. Additional chapters cover bombs and explosive devices, mental disease, epidemics, and issues related to forensic entomology. Each chapter contains a list of pertinent vocabulary and references for further study. By mastering the objectives contained in each chapter of this manual, forensic pathology students will be ready to pass certification exams and work confidently in the field.

Law and Evidence: A Primer for Criminal Justice, Criminology, and Legal Studies, Third Edition introduces the complex topic of evidence law in a straightforward and accessible manner. The use and function of evidence in both criminal and civil cases is examined to offer a complete understanding of how evidence principles play out in the real world of litigation and advocacy. This revised Third Edition includes new discussions of rules and case law analysis, forensic cases, and evidentiary software programs. Key Features: Every chapter contains new legal authority that apples to traditional legal principles relevant to evidence law Offers full coverage of evidentiary codes and statutes Provides practical forms, checklists, and additional tools throughout for use by current and future practitioners Course ancillaries including PowerPointTM lecture slides and an Instructor's Manual with Test Bank are available with qualified course adoption.

Knowledge of the three-dimensional structure of a protein is absolutely required for the complete understanding of its function. The spatial orientation of amino acids in the active site of an enzyme demonstrates how substrate specificity is defined, and assists the medicinal chemist in the design of s- cific, tight-binding inhibitors. The shape and contour of a protein surface hints at its interaction with other proteins and with its environment. Structural ana- sis of multiprotein complexes helps to define the role and interaction of each individual component, and can predict the consequences of protein mutation or conditions that promote dissociation and rearrangement of the complex. Determining the three-dimensional structure of a protein requires milligram quantities of pure material. Such quantities are required to refine crystallization conditions for X-ray analysis, or to overcome the sensitivity limitations of NMR spectroscopy. Historically, structural determination of proteins was limited to those expressed naturally in large amounts, or derived from a tissue or cell source inexpensive enough to warrant the use of large quantities of cells. H- ever, with the advent of the techniques of modern gene expression, many p- teins that are constitutively expressed in minute amounts can become accessible to large-scale purification and structural analysis.