Evolution of Fossil Ecosystems describes all of the main Fossil Lagerstatten (sites of exceptional fossil preservation) from around the world in a chronological order. It covers the history of research, stratigraphy and taphonomy, main faunal and floral elements, and the palaeoecology of each site and gives a comparison with coeval sites around the world. It includes all of the well-known fossil sites, such as the Burgess Shale, the Solnhofen Limestone, Mazon Creek, Rancho La Brea etc., and includes an appendix giving information on how to visit the sites and where to see the fossils in museum displays. Available now in its second edition, Lagerstatten included for the first time include Chengjiang, the Herefordshire Nodules and the Jehol Group. A welcome addition to the list of important localities of Cenozoic age is the White River Group, which preserves the finest examples of mammals around the Eocene-Oligocene boundary, including many now-extinct groups. The book is beautifully illustrated throughout with over 450 colour photographs and diagrams, and it is extensively referenced. Evolution of Fossil Ecosystems is essential reading to a wide range of students and professionals in palaeontology and related sciences, and to amateur enthusiasts.

Following its bestselling predecessor, Dimensions of Food, Eighth Edition, provides beneficial classroom and independent, instructive material for students. Instructors will find that this textbook's organization makes it easy to use and very flexible for teaching. A variety of stimulating experiences allow the student to explore and comprehend the numerous dimensions of food. Part I of this lab manual contains an analysis of economic, nutritional, palatability, chemical, sanitary, and food processing dimensions of food. Part II allows students to analyze the structural and functional properties of foods such as starches, fruits and vegetables, eggs, dairy, meat, poultry and fish, fats and oils, sweeteners, and baked goods. Part III features information on microwave cooking, and Part IV concludes with beneficial ideas on meal planning. All chapters in this informative and interactive insight into food science contain learning objectives, exercises, recipes, summary questions, and updated Dietitian's Notes. Contains several helpful Appendices on topics including: Food Guides and Dietary Guidelines, Food Equivalents, Portions, Food Allergens, Food Additives, Legislation, Foodborne Illness, Cooking Terms, Herbs and Spices, and Plant Proteins.

Cyberfeminism and Artificial Life examines construction, manipulation and re-definition of life in contemporary technoscientific culture. It takes a critical political view of the concept of life as information, tracing this through the new biology and the changing discipline of artificial life and its manifestation in art, language, literature, commerce and entertainment. From cloning to computer games, and incorporating an analysis of hardware, software and 'wetware', Sarah Kember demonstrates how this relatively marginal field connects with, and connects up global networks of information systems.
Ultimately, this book aims to re-focus concern on the ethics rather than on the 'nature' of life-as-it-could-be.

Statistical Approaches in Oncology Clinical Development : Current Paradigm and Methodological Advancement presents an overview of statistical considerations in oncology clinical trials, both early and late phase of development. It illustrates how novel statistical methods can enrich the design and analysis of modern oncology trials. The authors include many relevant real life examples from the pharmaceutical industry and academia based on their first-hand experience. Along with relevant references, the book highlights current regulatory views. The book covers all aspects of cancer clinical trial starting from early phase development. The early part of the book covers novel phase I dose escalation design, exposure response analysis, and innovative phase II design. This includes early development strategy for cancer immunotherapy trials. The contributors also emphasized the role of biomarker and modern era of precision medicine. The second part focuses on the late stage development. This includes the application of adaptive design, safety analysis, and quality of life (QoL) data analysis. The final part discusses current regulatory perspective and challenges. Features: Covers a wide spectrum of topics related to real-life statistical challenges in oncology clinical trials. Provides a comprehensive overview of novel statistical methods to improve trial design and statistical analysis. Detailed case studies illustrate the real life applications. Satrajit Roychoudhury is a Senior Director and a member of the Statistical Research and Innovation group in Pfizer Inc. Prior to joining; he was a member of Statistical Methodology and consulting group in Novartis. He has 11 years of extensive experience in working with different phases of clinical trial. His area of research includes early phase oncology trials, survival analysis, model informed drug development, and use of Bayesian methods in clinical trials. He is industry co-chair for the ASA Biopharmaceutical Section Regulatory-Industry Workshop and has provided statistical training in major conferences including the Joint Statistical Meetings, ASA Biopharmaceutical Section Regulatory-Industry Workshop, and ICSA Applied Statistics Symposium. Soumi Lahiri has 12 years of extensive experience in working different therapeutic areas. She is the former Director of Biostatistics in Clinical Oncology, GlaxoSmithKline. She has also worked in the oncology division of Novartis Pharmaceutical Company for two years. She is an active member of the ASA Biopharmaceutical section and former chair of the membership committee.

We regularly find ourselves in food environments that promote the consumption of high fat and sugary foods rather than encouraging us to eat more fruit and vegetables. However, because of increased media attention, people are becoming more interested in alternative approaches to improving the many food-related decisions we make daily. Transforming Food Environments features evidence from several disciplines exploring initiatives that have improved food environments and discusses the importance of achieving success in equitable and sustainable ways. The book presents information on diverse food environments followed by methods that help readers become aware of the design of interventions and food policies. It covers food environments in schools, workplaces, and community centres as well as fast food establishments and food marketing. The book presents methods to help encourage better food choices and purchase of healthier foods. It explores persuasion tactics used by health professionals such as changing availability and/or price, using nudging techniques, and food labelling. Led by Editor Charlotte Evans, Associate Professor of Nutritional Epidemiology and Public Health Nutrition at the University of Leeds; and written by an international range of authors from countries including the US, Canada, Australia, New Zealand, Japan and the United Kingdom, this multidisciplinary book appeals to students, researchers, public health professionals and policy makers. It also raises awareness and provides a comprehensive treatment of the importance of our environments on food choice.

Bioinformatics, the use of computers to address biological questions, has become an essential tool in biological research. It is one of the critical keys needed to unlock the information encoded in the flood of data generated by genome, protein structure, transcriptome and proteome research.
Bioinformatics: Genes, Proteins & Computers covers both the more traditional approaches to bioinformatics, including gene and protein sequence analysis and structure prediction, and more recent technologies such as datamining of transcriptomic and proteomic data to provide insights on cellular mechanisms and the causes of disease.

The book provides insight on the osteology, myology, phylogeny and evolution of Osteichthyes. It not only provides an extensive cladistic analysis of osteichthyan higher-level inter-relationships based on a phylogenetic comparison of 356 characters in 80 extant and fossil terminal taxa representing all major groups of Osteichthyes, but also analyses various terminal taxa and osteological characters. And also provides a general discussion on issues such as the comparative anatomy, homologies and evolution of osteichthyan cranial and pectoral muscles, the development of zebrafish cephalic muscles and the implications for evolutionary developmental studies, the origin homologies and evolution of one of the most peculiar and enigmatic structural complexes of osteichthyans, the Weberian apparatus, and the use of myological versus osteological characters in phylogenetic reconstructions.

A complete guide to the drug development outsourcing relationship, sponsor companies and CROs alike will appreciate the industry-wide analysis, practical, how-to advice, and helpful charts and checklists provided by Outsourcing in Clinical Drug Development. A panel of experts discuss supplier identification and selection, financial considerations, and the ethical issues. They cover contracting out laboratory analysis, data management, and statistical services, and the effects of outsourcing on quality assurance. Whether readers are just exploring the possibility of outsourcing or already involved in long-term strategic outsourcing partnerships, this book is an invaluable resource.

Many current public health actions and policies aimed at older people revolve around the often prevailing view that failing health is a consequence of ageing. It is now clear that it is possible to postpone or even prevent much of the age-related decline in health that was once thought inevitable. Future policies must recognise this changing paradigm, and, using a multi-disciplinary approach, integrate fully the changing needs of older people into all areas of public policy including health, nutrition, social support, housing, and economic security. Derived from the 47th Annual Symposium of the Society for the Study of Human Biology in November 2005, Ageing Well: Nutrition, Health, and Social Interventions highlights important health and social factors affecting quality of life in older age, and reviews possible interventions aimed at the prevention or amelioration of problems that reduce the potential for ageing well. Covering a wide range of topics, contributors address the nutritional vulnerability and specific nutritional needs of older adults and confirm the necessity of appropriate diet and exercise in order to maintain both physical and cognitive health. Reminiscence, social interaction and support are highlighted as crucial for the preservation of identity, health and emotional well-being. Other chapters are concerned with socio-economic differences in the extent of age-related changes in health, resulting particularly from poor quality housing and lack of family support networks. The book includes an examination of the economic consequences for health care systems and pension schemes of ageing populations, provides insight into the methodology of evaluating the cost-effectiveness of interventions, and outlines how the minimum cost of healthy living for the 65 plus population can be estimated. Bringing together the very latest information on successful ageing, Ageing Well: Nutrition, Health, and Social Interventions presents an up

Theory of Drug Development presents a formal quantitative framework for understanding drug development that goes beyond simply describing the properties of the statistics in individual studies. It examines the drug development process from the perspectives of drug companies and regulatory agencies. By quantifying various ideas underlying drug development, the book shows how to systematically address problems, such as: Sizing a phase 2 trial and choosing the range of p-values that will trigger a follow-up phase 3 trial Deciding whether a drug should receive marketing approval based on its phase 2/3 development program and recent experience with other drugs in the same clinical area Determining the impact of adaptive designs on the quality of drugs that receive marketing approval Designing a phase 3 pivotal study that permits the data-driven adjustment of the treatment effect estimate Knowing when enough information has been gathered to show that a drug improves the survival time for the whole patient population Drawing on his extensive work as a statistician in the pharmaceutical industry, the author focuses on the efficient development of drugs and the quantification of evidence in drug development. He provides a rationale for underpowered phase 2 trials based on the notion of efficiency, which leads to the identification of an admissible family of phase 2 designs. He also develops a framework for evaluating the strength of evidence generated by clinical trials. This approach is based on the ratio of power to type 1 error and transcends typical Bayesian and frequentist statistical analyses.

Mathematical Morphology in Geomorphology and GISci presents a multitude of mathematical morphological approaches for processing and analyzing digital images in quantitative geomorphology and geographic information science (GISci). Covering many interdisciplinary applications, the book explains how to use mathematical morphology not only to perform quantitative morphologic and scaling analyses of terrestrial phenomena and processes, but also to deal with challenges encountered in quantitative spatial reasoning studies. For understanding the spatiotemporal characteristics of terrestrial phenomena and processes, the author provides morphological approaches and algorithms to: Retrieve unique geomorphologic networks and certain terrestrial features Analyze various geomorphological phenomena and processes via a host of scaling laws and the scale-invariant but shape-dependent indices Simulate the fractal-skeletal-based channel network model and the behavioral phases of geomorphologic systems based on the interplay between numeric and graphic analyses Detect strategically significant sets and directional relationships via quantitative spatial reasoning Visualize spatiotemporal behavior and generate contiguous maps via spatial interpolation Incorporating peer-reviewed content, this book offers simple explanations that enable readers-even those with no background in mathematical morphology-to understand the material. It also includes easy-to-follow equations and many helpful illustrations that encourage readers to implement the ideas.

The first edition of this book, Basic Concepts in Organ Procurement, Perfusion and Preservation for Transplantation, was published 27 years ago, in 1982 when organ procurement and preservation began to advance in the study of the best ways to preserve organs for transplantation. The second edition, Organ Procurement and Preservation for Transplantation, 2nd Edition, followed 15 years later, in 1997, with the goal of finding common denominators in the best preservation techniques for transplantation. In this current third edition, 11 years after the second edition, similar goals are still pursued of defining the best preservation methods, but there is now more evidence, including results, and new advances have reached publication and are being incorporated into ischemia and reperfusion techniques and organ preservation studies. Many preservation solutions have been introduced, important preservation solution components have been better defined, and improved perfusion methods are being considered, especially for the increasing number of organ donors with non-beating hearts who are being sought for transplantation. This edition (2009) engaged experts in the field of organ preservation to review, update, and rewrite each of the chapters. Crafted in collaboration with Luis H. Toledo-Pereyra, the text is eminently informative and easily understandable. Each solid organ that can be transplanted has an entire chapter devoted to the particular methods of its preservation. One chapter apiece, in other words, features insights on the preservation of the kidney, the liver, the pancreas, the small bowel, the heart, and the heart-lung. The title of the present book has been shortened to better represent its content. Thus, Organ Preservation for Transplantation, 3rd Edition, demonstrates a more accurate depiction of its current status. Nevertheless, the goal of this book remains exactly the same as in the first edition, that is "to analyze the most important aspects of organ procurement, perfusion and preservation for transplantation".

Cowan's, Microbiology:A Systems Approach is the perfect book for all students. Whether yourstudents have prerequisite knowledge of biology or chemistry, this textbookwill help them learn the fascinating world of microbiology. Students interestedin allied health or nursing, will love this book for its balanced coverage ofthe basics and clinical applications.

This reference outlines important applications of statistics for each stage of pharmaceutical development to ensure the valid design, analysis, and assessment of drug products under investigation in order to establish the safety and efficacy of pharmaceutical compounds. Reinforcing the role of good statistical practices (GSP) in drug research and formulation, Statistics in Drug Research is an essential source for biostatisticians; pharmacologists; clinical, industrial, and research pharmacists; statisticians and applied statisticians; biometricians; quality control personnel; drug regulatory personnel; and upper-level undergraduate and graduate students in these disciplines.

Written to help companies comply with GMP, GLP, and validation requirements imposed by the FDA and regulatory bodies worldwide, Quality Control Training Manual: Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories presents cost-effective training courses that cover how to apply advances in the life sciences to produce commercially viable biotech products and services in terms of quality, safety, and efficacy. This book and its accompanying downloadable resources comprise detailed text, summaries, test papers, and answers to test papers, providing an administrative solution for management. Provides the FDA, Health Canada, WHO, and EMEA guidelines directly applicable to pharmaceutical laboratory-related issues Offers generic formats and styles that can be customized to any organization and help management build quality into routine operations to comply with regulatory requirements Contains ready-to-use training courses that supply a good source of training material for experienced and inexperienced practitioners in the biotechnology/biopharmaceutical industries Includes downloadable resources with downloadable training courses that can be adopted and directly customized to a particular organization Supplies ready-to-use test papers that allow end users to record all raw data up to the issuance of the attached certificate The biotechnology/bioscience industries are regulated worldwide to be in compliance with cGMP and GLP principles, with particular focus on safety issues. Each company must create a definite training matrix of its employees. The training procedures in this book enable end users to understand the principles and elements of manufacturing techniques and provide documentation language ranging from the generic to the specific. The training courses on the downloadable resources supply valuable tools for developing training matrices to achieve FDA, Health Canada, EMEA, MHRA UK, WHO, and GLP compliance.

Compiled with the most sophisticated chromatographic and spectrometric instruments available, this complete and self-contained seven-volume reference provides forensic, toxicology, and clinical laboratories with up-to-date information on 1,600 drugs and drug-related compounds-one of the largest collections of analytical data generated from a single source. Instrumental Data for Drug Analysis contains timely, quality data presented in a large, easily usable format. It is an essential reference in the libraries of all toxicology, analytical chemistry, and forensic specialists and laboratories.

Unprecedented advances in genetics and biotechnology have brought profound new insights into human biological variation. These present challenges and opportunities for understanding the origins of human nature, the nature of difference, and the social practices these sustain. This provides an opportunity for cooperation between the biological and social sciences one that is capable of prompting a synergistic exchange of ideas with far-reaching implications. The Nature of Differencecritically analyses biological explanations for morality, criminality, race, sexuality, and disability. Based on the 45th annual symposium of the Society for the Study of Human Biology, this work synthesizes the perspectives of established experts in the field of human biology with those studying the social meanings of human biological variation and scientific practices in human biological research. Some questions addressed by The Nature of Difference: Is there a biological basis for morality, criminality, witchcraft, sexuality or disability? What do comparisons of humans and apes tell us about society? How do people draw on scientific methods to justify racism? Why do geneticists continue to use racial categories in their research? Do ethical guidelines constrain or facilitate research into human biology? Can science and society escape from biological determinism? As biotechnology expands the frontiers of what we know and what we are able to do, and as the genomic revolution moves out of the laboratory and into our daily lives, we are faced with a number of pressing social issues that need to be resolved. Offering an unparall

Much has happened in the area of bulk pharmaceutical good manufacturing practice (GMP) and validation since the first publication of Validation of Active Pharmaceutical Ingredients. Revised, updated, and expanded, this second edition includes new chapters addressing postapproval changes, technology transfer, international cGMP guidelines/FDA guidance progress, and facility inspection issues. The basic philosophy and principles of GMP and validation have not changed, but new terminology had been introduced, and old terminology had been better defined, improving the understanding of related concepts and principles. The book gives you a working knowledge of the regulatory process that will facilitate your organization's compliance with regulations.

Using time-to-event analysis methodology requires careful definition of the event, censored observation, provision of adequate follow-up, number of events, and independence or "noninformativeness" of the censoring mechanisms relative to the event. Design and Analysis of Clinical Trials with Time-to-Event Endpoints provides a thorough presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest. After reviewing time-to-event endpoint methodology, clinical trial issues, and the design and monitoring of clinical trials, the book focuses on inferential analysis methods, including parametric, semiparametric, categorical, and Bayesian methods; an alternative to the Cox model for small samples; and estimation and testing for change in hazard. It then presents descriptive and graphical methods useful in the analysis of time-to-event endpoints. The next several chapters explore a variety of clinical trials, from analgesic, antibiotic, and antiviral trials to cardiovascular and cancer prevention, prostate cancer, astrocytoma brain tumor, and chronic myelogonous leukemia trials. The book then covers areas of drug development, medical practice, and safety assessment. It concludes with the design and analysis of clinical trials of animals required by the FDA for new drug applications. Drawing on the expert contributors' experiences working in biomedical research and clinical drug development, this comprehensive resource covers an array of time-to-event methods and explores an assortment of real-world applications.

The dangers and drawbacks inherent in radioactivity-based methods along with a demonstrated and dramatic increase in sensitivity have precipitated a major shift towards luminescence measurements and visualization techniques. Their use has now spread even to traditional clinical environments, and their applications have grown from clinical assays to DNA sequencing, antioxidant detection, and high-throughput screening.

Luminescence Biotechnology: Instruments and Applications furnishes a thorough w review of the principles and applications of luminescence. With a consistent focus on practical considerations, contributions from a team of internationally acclaimed authors take you from the fundamentals of the different luminescence-based assay systems, calculation methods, and instruments through the spectrum of applications and latest research advances. Topics include gene and protein assays, oxidative stress and tissue aging, applications of luminescent microspheres, and proton image analysis.

This book clearly identifies the advantages of luminescence over other assay techniques, discusses its potential pitfalls, and illustrates the broad range of its utility. Whether you are a newcomer to the field or a seasoned professional, this book provides a wealth of information that will bring you quickly up to date on the technology, recent research developments, and cutting-edge applications.

The use of statistics in biology, medicine, engineering, and the sciences has grown dramatically in recent years and having a basic background in the subject has become a near necessity for students and researchers in these fields. Although many introductory statistics books already exist, too often their focus leans towards theory and few help readers gain effective experience in using a standard statistical software package.

Designed to be used in a first course for graduate or upper-level undergraduate students, Basic Statistical Methods and Models builds a practical foundation in the use of statistical tools and imparts a clear understanding of their underlying assumptions and limitations. Without getting bogged down in proofs and derivations, thorough discussions help readers understand why the stated methods and results are reasonable. The use of the statistical software Minitab is integrated throughout the book, giving readers valuable experience with computer simulation and problem-solving techniques. The author focuses on applications and the models appropriate to each problem while emphasizing Monte Carlo methods, the Central Limit Theorem, confidence intervals, and power functions.

The text assumes that readers have some degree of maturity in mathematics, but it does not require the use of calculus. This, along with its very clear explanations, generous number of exercises, and demonstrations of the extensive uses of statistics in diverse areas applications make Basic Statistical Methods and Models highly accessible to students in a wide range of disciplines.

This work provides current models, tools, and examples for the formulation and evaluation of scientific hypotheses in causal terms. It introduces a new method of model parametrization, and illustrates structural equations and graphical elements for complex causal systems.

Essentials of Environmental Science is ideal for a one-semester course. It takes the same non-biased approach as its parent text, teaching students to think critically about data presented. In addition to being briefer, Essentials is even more accessible placing less emphasize on math calculations. The coverage of ecology, agriculture, energy, and water has also been streamlined to provide a more focused treatment of the science concepts.

Her Brentwood home became a hotbed for homicide. But in the wake of intense public and media attention, one saliant and hard truth was often overlooked: the murder of Nicole Brown-Simpson, while brutal and heinous in its form, was just one of thousands of homicides committed during that same year. Most escaped the scrutiny of public interest. Many never made it to trial, and still others were dismissed as natural deaths-perfect crimes that remain forever unsolved. How, then, do investigators solve a murder when the trail goes cold? Like mariners navigating without landmarks under a starless night sky-lacking a reliable witness or smoking gun-they plot their course through the clues by applying their own style of Dead Reckoning, reconstructing the crime by disciplined observation, careful reasoning, and experience. Dead Reckoning: The Art of Forensic Detection examines the applications of logic and science to decipher chaotic death scenes and difficult cases, and to derive orderly explanations from their jumbled clues. The 10 case studies in this book illustrate the powers of observation exercised in reading the signs, identifying them as clues, and reasoning from them to the best explanation. For investigators, as well as forensic pathologists, coroners, prosecutors, and defense attorneys, Dead Reckoning: The Art of Forensic Detection stresses the importance of trusting your own observations even in the wake of contradictory evidence.

This book focuses on analytical similarity assessment in biosimilar product development following the FDA's recommended stepwise approach for obtaining totality-of-the-evidence for approval of biosimilar products. It covers concepts such as the tiered approach for assessment of similarity of critical quality attributes in the manufacturing process of biosimilar products, models/methods like the statistical model for classification of critical quality attributes, equivalence tests for critical quality attributes in Tier 1 and the corresponding sample size requirements, current issues, and recent developments in analytical similarity assessment.