Despite 40 years of aggressive pharmaceutical and surgical interventions, coronary artery disease remains the number one killer of women and men in Western civilization. Cardiovascular disease, more than ever, demonstrates the landscape has changed so significantly, that new information must be given to the young and old health professionals seeing patients on a day to day basis. Dr. Sinatra has 40 plus years of experience in cardiovascular disease and is board-certified in internal medicine and cardiology. Dr. Mark Houston practices integrative nutritional preventive cardiology and has superb expertise in hypertension, and dyslipidemia which are major factors in the genesis of cardiovascular disease. The information in this book will give doctors-to-be, and even doctors-that-are the overlooked information they need for a balanced approach to cardiovascular treatment that includes a healing/healthy diet, nutritional supplementation, exercise and weight management. Those are crucial and powerful additions to the toolbox with which to maintain health and fix problems. That's the integrative approach that Dr. Sinatra, Dr Houston and his fellow authors, have been using with great success for decades. The Table of Contents shows a true revision - all new material - this is more of a companion volume to the original edition.

This volume features contributions from participants of an ESRF Workshop on "Systems Biology" held in Berkeley, USA, in November 2005. Significant progress has been made in developing technologies that enable systems interrogations at a molecular level. Overwhelming data sets are generated ever faster, providing enormous detail. In order to be useful, however, all these data must be appropriately integrated, analyzed in the context of all other information available and eventually modelled, enabling predictions for therapeutic interventions. Recent successes and challenges of applying systems level measurements to the different steps of drug discovery and development in the pharmaceutical industry are summarized.

The first "Big History" written from the perspective of a biologist Summarizes multiple perspectives of history Documents the unique conditions for the emergence of life Speculates on the future

Emphasis in agricultural production has shifted from mere quantity to quality products. Practical experience and scientific investigations have shown that, of the various culture measures, balanced fertilization above all exerts a considerable influence on the quality of agricultural products. Simply adding more of what the crop has already absorbed to capacity is unproductive, expensive, wasteful and damaging to the environment. Therefore, balanced crop nutrition increases crop quality, safeguards natural resources and brings benefit to the farmer. Otherwise rapid population growth and severe urbanization will exhaust our natural resources.

-Describes the basic ideas underlying each concept and model. -Includes R, SAS, SPSS and Stata programming codes for all the examples -Features significantly expanded Chapters 4, 5, and 8 (Chapters 4-6, and 9 in the second edition. -Expands discussion for subtle issues in longitudinal and clustered data analysis such as time varying covariates and comparison of generalized linear mixed-effect models with GEE.

This book addresses topics of mobile multi-agent systems, pattern formation, biological modelling, artificial life, unconventional computation, and robotics. The behaviour of a simple organism which is capable of remarkable biological and computational feats that seem to transcend its simple component parts is examined and modelled. In this book the following question is asked: How can something as simple as Physarum polycephalum - a giant amoeboid single-celled organism which does not possess any neural tissue, fixed skeleton or organised musculature - can approximate complex computational behaviour during its foraging, growth and adaptation of its amorphous body plan, and with such limited resources? To answer this question the same apparent limitations as faced by the organism are applied: using only simple components with local interactions. A synthesis approach is adopted and a mobile multi-agent system with very simple individual behaviours is employed. It is shown their interactions yield emergent behaviour showing complex self-organised pattern formation with material-like evolution. The presented model reproduces the biological behaviour of Physarum; the formation, growth and minimisation of transport networks. In its conclusion the book moves beyond Physarum and provides results of scoping experiments approximating other complex systems using the multi-agent approach. The results of this book demonstrate the power and range of harnessing emergent phenomena arising in simple multi-agent systems for biological modelling, computation and soft-robotics applications. It methodically describes the necessary components and their interactions, showing how deceptively simple components can create powerful mechanisms, aided by abundant illustrations, supplementary recordings and interactive models. It will be of interest to those in biological sciences, physics, computer science and robotics who wish to understand how simple components can result in complex and useful behaviours and who wish explore the potential of guided pattern formation themselves.

Begins a series publishing courses and educational seminars organized by the Commission of European Communities' Joint Research Centre at Ispra, Italy. Perhaps as the series matures, responsible parties will see the wisdom of not trusting authors to present readable typescripts, of mentioning where

This book explains how to analyze independent data from factorial designs without having to make restrictive assumptions, such as normality of the data, or equal variances. The general approach also allows for ordinal and even dichotomous data. The underlying effect size is the nonparametric relative effect, which has a simple and intuitive probability interpretation. The data analysis is presented as comprehensively as possible, including appropriate descriptive statistics which follow a nonparametric paradigm, as well as corresponding inferential methods using hypothesis tests and confidence intervals based on pseudo-ranks. Offering clear explanations, an overview of the modern rank- and pseudo-rank-based inference methodology and numerous illustrations with real data examples, as well as the necessary R/SAS code to run the statistical analyses, this book is a valuable resource for statisticians and practitioners alike.

Diese Kompaktausgabe der Enzyklopadie der Holzgewachse, des unangefochtenen Standardwerkes der Dendrologie, beschreibt die in Mitteleuropa heimischen Baumarten, einschlieA lich aller jemals gekA1/4rten Baume des Jahres. Nach dem aktuellsten Stand des Wissens werden rund fA1/4nfzig Arten aus vierundzwanzig Gattungen vorgestellt, darunter haufig vorkommende wie WeiA tanne oder Sommerlinde, aber auch heimische Exoten wie Schneebirne oder Zirbelkiefer. Zahlreiche Farbfotos und Schemazeichnungen veranschaulichen Wuchsform und morphologische Besonderheiten wie Rinde, Laub und FrA1/4chte. Wichtige Aspekte zu A-kologie, Klima, Standort, Waldbau und Nutzung durch den Menschen wurden in bewahrter Qualitat zusammengestellt und von ausgewiesenen Fachleuten redigiert. Ein einzigartiger A berblick A1/4ber die heimische Gehoelzflora, fA1/4r alle Baumkenner und solche, die es werden wollen.

This detailed volume spotlights methods to investigate a variety of virus-host interactions in humans, other mammals, fish, or insects. It explores viruses such as white spot syndrome virus (WSSV), honeybee viruses, Nipah virus, EBV, SVCV, HSV-1, HIV-1, A H1N1, and SARS-CoV-2, as well as applications of techniques such as qPCR, serum antibody responses, 4C analysis, cell membrane fusion, biosensors, computational modelling, quantitative proteomics, and other genetic tools to decipher those viral infections and interactions. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Virus-Host Interactions: Methods and Protocols serves as a valuable resource for researchers both in academia and in the biosciences industry who are engaged in the search for a better understanding of threatening virus-hosts interactions, virus detection, their characterization, and ultimately their taming and control.

Papers presented at the Schliersee Meeting on Nucleo-mitochondrial Interactions, held July 19-23, 1983.

I was pleased and at the same time filled with some misgivings when Professors Alberto Giotti end Ryan Huxtable asked me to introduce this book. The book is the outcome of the Symposium held in Firenze-San Miniato (PI), October 6-9, 1986. The symposium was entitled "Sulfur Amino Acids, Peptides and Related Compounds" and was the 7th international symposium on taurine ssnd assooiated substances. It is always difficult to introduce, with the right brevity end emphasis, a topic which has been studied in depth by numerous experte. Nevertheless, I shall do my best to give a historical perspeotive of the subjects of the meeting which I consider to be very important for the frontiers of researoh on taurine. ~he following topios have also beoome coherent areas of study during the development of researoh on taurine: metabolism, nutrition, neurochemistry, cardiovasoular regulation. Although taurine was isolated in 1821 by ~iedman and Gmel1n, its only biochemioal role known at the time was the synthesis of bile saIte in mammalian tissue. There has been an inoreasing interest in the biologioal action of taurine from metabolio aspects to other biologioal aspects (nutrition, development, eto.). In 1975 it was first demonstrated that taurine deprivation produoed retinal degeneration in cats; more reoent studies showed that a taurine-free diet or the administration of taurine transport inhibitors caused retinal degeneration in other mammlas. More reoent studies have pointed out the role of taurine in development, and the first part of this book is dedicated to these topios.

Modern computer-intensive statistical methods play a key role in solving many problems across a wide range of scientific disciplines. Like its bestselling predecessors, the fourth edition of Randomization, Bootstrap and Monte Carlo Methods in Biology illustrates a large number of statistical methods with an emphasis on biological applications. The focus is now on the use of randomization, bootstrapping, and Monte Carlo methods in constructing confidence intervals and doing tests of significance. The text provides comprehensive coverage of computer-intensive applications, with data sets available online. Features Presents an overview of computer-intensive statistical methods and applications in biology Covers a wide range of methods including bootstrap, Monte Carlo, ANOVA, regression, and Bayesian methods Makes it easy for biologists, researchers, and students to understand the methods used Provides information about computer programs and packages to implement calculations, particularly using R code Includes a large number of real examples from a range of biological disciplines Written in an accessible style, with minimal coverage of theoretical details, this book provides an excellent introduction to computer-intensive statistical methods for biological researchers. It can be used as a course text for graduate students, as well as a reference for researchers from a range of disciplines. The detailed, worked examples of real applications will enable practitioners to apply the methods to their own biological data.

Russell/Hertz/McMillan, BIOLOGY: THE DYNAMIC SCIENCE 4e and MindTap teach Biology the way scientists practice it by emphasizing and applying science as a process. You learn not only what scientists know, but how they know it, and what they still need to learn. The authors explain complex ideas clearly and describe how biologists collect and interpret evidence to test hypotheses about the living world. Throughout, Russell and MindTap provide engaging applications, develop quantitative analysis and mathematical reasoning skills, and build conceptual understanding.

This book presents a comprehensive typology and a comprehensible description of spatiotemporal models used in population dynamics. The main types included are: reaction-diffusion systems, patch models, matapopulation approaches, host parasitoid models, cellular automata (interacting particle systems), tessellations and distance models. The models are introduced through examples and with informative verbal explanations to help understanding. Some of the cellular automation examples are models not yet published elsewhere. Possible extensions of certain model types are suggested.

By the year 2050, the world's population is expected to reach nine billion. To feed and sustain this projected population, world food production must increase by at least 50 percent on much of the same land that we farm today. To meet this staggering challenge, scientists must develop the technology required to achieve an "evergreen" revolution -- one that increases crop productivity without degrading natural resources. With 30 percent new material, the updated and revised third edition of Growth and Mineral Nutrition of Field Crops covers all aspects of crop growth and mineral nutrition that contribute to sustainable, high-yield agriculture. Bringing together international scientific knowledge of crop production and the impacts of agriculture on the environment, this book: * Includes two new chapters on remediation of heavy-metal contaminated soils and cover crops * Covers theoretical and practical aspects of mineral nutrition of field crops * Provides recommendations for judicious use of fertilizers, which will reduce cost of crop production and enhance high crop yields without risking environmental pollution * Provides growth patterns for annual crops and forages * Includes a handful of color pictures of nutrient deficiencies for easy diagnostic purposes To make the book as practical as possible, each chapter is supported by experimental results and extensive references. A large number of figures and tables are also included to save readers time when researching. The overall emphasis of this reference is on the soil's ability to sustain high crop yields and a healthy human population.

This three-volume set of Pharmaceutical Dosage Forms: Parenteral Medications is an authoritative, comprehensive reference work on the formulation and manufacture of parenteral dosage forms, effectively balancing theoretical considerations with the practical aspects of their development. As such, it is recommended for scientists and engineers in the pharmaceutical industry and academia, and will also serve as an excellent reference and training tool for regulatory scientists and quality assurance professionals.

First published in 1984 (as two volumes) and then last revised in 1993 (when it grew to three volumes), this latest revision will address the plethora of changes in the science and considerable advances in the technology associated with these products and routes of administration. The third edition of this book maintains the features that made the last edition so popular but comprises several brand new chapters, revisions to all other chapters, as well as high quality illustrations.

Volume one presents:

A historical perspective of injectable drug therapy, common routes of administration, and biopharmaceutics of NCEs and NBEs.

An in-depth discussion on the preformulation and formulation of small and large molecules, including ophthalmic dosage forms.

A presentation of parenteral primary packaging options - glass and plastic containers, as well as elastomeric closures.

A definitive chapter on container-closure integrity.

New chapters on solubility and solubilization, formulation of depot delivery systems and biophysical/biochemical characterization of proteins.

Volume two presents:

Chapters on aseptic facility design, environmental monitoring, and cleanroom operations.

A comprehensive chapter on pharmaceutical water systems.

A discussion of quality attributes of sterile dosage forms, including particulate matter, endotoxin, and sterility testing.

A detailed chapter on processing of parenteral drug products (SVPs and LVPs).

Presentations on widely used sterilization technologies steam, gas / chemical, radiation, filtration and dry heat.

An in-depth chapter on lyophilization.

Volume three presents:

An in-depth discussion of regulatory requirements, quality assurance, risk assessment and mitigation, and extractables/leachables.

Specific chapters on parenteral administrations devices, injection site pain assessment, and parenteral product specifications and stability testing.

Forward-thinking discussions on the future of parenteral product manufacturing, and siRNA delivery systems.

New chapters covering recent developments in the areas of visual inspection, quality by design (QbD), process analytical technology (PAT) and rapid microbiological methods (RMM ), and validation of drug product manufacturing process.

This book introduces advanced semantic web technologies, illustrating their utility and highlighting their implementation in biological, medical, and clinical scenarios. It covers topics ranging from database, ontology, and visualization to semantic web services and workflows. The volume also details the factors impacting on the establishment of the semantic web in life science and the legal challenges that will impact on its proliferation.