The screech of rubber against asphalt. And then the crash: a violent two-car collision resulting in a twisted mass of metal, plastic, and glass-and worse, the deaths of both drivers. Accident reconstruction is but one phase of road traffic fatality (RTF) cases. Even as police officers draw their last diagram, interview their last witness, and reconstruct their final scenario, a different team of investigators works diligently on solving another puzzle: determining how the victims actually died. Investigation of Road Traffic Fatalities: An Atlas covers the issues that face medical examiners and coroners in determining the nature and extent of RTF injuries as well as the cause, manner, and circumstances of death. Also ideal for medicolegal death investigators and law enforcement personnel who work with medical examiners and coroners during RTF investigations, this Atlas covers everything from "Typical road traffic fatality injuries" to "Injuries caused by safety/restraint devices" and "Autopsy and toxicology testing." For anyone involved in RTF probes, Investigation of Road Traffic Fatalities: An Atlas is essential reading.

For nearly forty years, using recombinant DNA tools, researchers, and then businesses, have genetically engineered organisms by transferring naturally occurring genes from one organism into another. Doing so modifies the genetic code of living cells, imparting new traits and achieving desired results; this is done in the production of proteins, pharmaceuticals, and seeds. Synthetic biology, argues Solomon, could free scientists from the need to find natural genes to make such desired modifications.Synthetic biology permits more complex and sophisticated bioengineering than what can be achieved through previous genetic modification techniques. Drawing on non-biological scientific and engineering disciplines, including information technology and nanotechnology, synthetic biology strives to rearrange an organism's genes on a far wider scale by rewriting its genetic code, the chemical instructions need to design, assemble, and operate a species. By allowing the writing of artificial genetic codes, synthetic biology can transform existing industries and spawn new ones, creating new products as well as radically reshaping existing items.Arguing for self-regulation by the scientific and business communities, Lewis D. Solomon recommends a policy framework that would guard against governmental overregulation, which could create a barrier to innovation. Although synthetic biotechnology holds considerable social and economic potential, absent a nurturing regulatory climate, it may prove difficult to translate research discoveries into commercially viable applications.

Charles Darwin is well-known throughout the world for his revolutionary work from 1859; The Origin of Species, the foundational study of evolution which greatly challenged the near-universal belief in the Christian world, at that time, of creationism. Originally published in 1928, Dorsey attempts to provide a detailed account of the scientist's life and personality informed by letters, published works and an autobiography written by Darwin. Darwin's life was full of challenges both in his personal life as well as his career and The Evolution of Charles Darwin explores all aspects of his life from birth to death emphasising the great impact his work had in the scientific community and humanity as a whole.

Makes mathematical and statistical analysis understandable to even the least math-minded biology student This unique textbook aims to demystify statistical formulae for the average biology student. Written in a lively and engaging style, Statistics for Terrified Biologists, 2nd Edition draws on the author's 30 years of lecturing experience to teach statistical methods to even the most guarded of biology students. It presents basic methods using straightforward, jargon-free language. Students are taught to use simple formulae and how to interpret what is being measured with each test and statistic, while at the same time learning to recognize overall patterns and guiding principles. Complemented by simple examples and useful case studies, this is an ideal statistics resource tool for undergraduate biology and environmental science students who lack confidence in their mathematical abilities. Statistics for Terrified Biologists presents readers with the basic foundations of parametric statistics, the t-test, analysis of variance, linear regression and chi-square, and guides them to important extensions of these techniques. It introduces them to non-parametric tests, and includes a checklist of non-parametric methods linked to their parametric counterparts. The book also provides many end-of-chapter summaries and additional exercises to help readers understand and practice what they've learned. Presented in a clear and easy-to-understand style Makes statistics tangible and enjoyable for even the most hesitant student Features multiple formulas to facilitate comprehension Written by of the foremost entomologists of his generation This second edition of Statistics for Terrified Biologists is an invaluable guide that will be of great benefit to pre-health and biology undergraduate students.

Introductory Mathematics for the Life Sciences offers a straightforward introduction to the mathematical principles needed for studies in the life sciences. Starting with the basics of numbers, fractions, ratios, and percentages, the author explains progressively more sophisticated concepts, from algebra, measurement, and scientific notation through the linear, power, exponential, and logarithmic functions to introductory statistics. Worked examples illustrate concepts, applications, and interpretations, and exercises at the end of each chapter help readers apply and practice the skills they develop. Answers to the exercises are posted at the end of the text.

The use of statistics is fundamental to many endeavors in biology and geology. For students and professionals in these fields, there is no better way to build a statistical background than to present the concepts and techniques in a context relevant to their interests. Statistics with Applications in Biology and Geology provides a practical introduction to using fundamental parametric statistical models frequently applied to data analysis in biology and geology. Based on material developed for an introductory statistics course and classroom tested for nearly 10 years, this treatment establishes a firm basis in models, the likelihood method, and numeracy. The models addressed include one sample, two samples, one- and two-way analysis of variance, and linear regression for normal data and similar models for binomial, multinomial, and Poisson data. Building on the familiarity developed with those models, the generalized linear models are introduced, making it possible for readers to handle fairly complicated models for both continuous and discrete data. Models for directional data are treated as well. The emphasis is on parametric models, but the book also includes a chapter on the most important nonparametric tests. This presentation incorporates the use of the SAS statistical software package, which authors use to illustrate all of the statistical tools described. However, to reinforce understanding of the basic concepts, calculations for the simplest models are also worked through by hand. SAS programs and the data used in the examples and exercises are available on the Internet.

The book opens with a survey by Dr. Motron Cowan of biotin-responsive metabolic disorders of children. A group of Japanese researchers then present their latest data on the complex interactions between vitamin D and parathyroid hormone (PTH) in bone calcification. Dr. Maxine Briggs reviews the prolific published information relating vitramin C to infectious diseases and presents the results of an 8 year study into the prophylactic value of high-dose ascorbic acid (AA) and the common cold. Professor Kristoffersen and Dr. Rolschau review the effects of vitamin supplements during pregnancy and intrauterine growth. Possible protective effects of vitamin A and other retinoids against cancer are discussed by Dr. Jill Blunck, while Dr. Sue Tonkin describes her results on the interaction between oral contraceptives and riboflavin. Finally, the possible prevention of neural tube defects by vitamin supplements by Professor Laurence. It is hoped that this collection of papers on the frontiers of vitamin research will be of wide interest to medical and scientific workers interested in the exciting and controversial used and functions of vitamins.

More than a checklist of audit questions, this guidebook provides proven methods and techniques for performing effective audits that serve your department, your company, and you. Topics covered relate to the four key competencies essential for successful GMP audits. Includes the rationale for auditing as an important quality tool, along with the audit cycle, broken into five distinct phases. To focus the power of auditing on a particular situation, several different types of audits are presented, as are more than a dozen audit approaches with general questions to answer and specific items to examine. These tools will help you prepare checklists and standards so audits become more effective, consistent, and standardized. The book includes profiles of seasoned professionals in drug and device auditing, who share their experiences (the good and the bad)

This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches.

Handbook of Forensic Pathology, Second Edition is an up-to-date, concise manual illustrating all core aspects of modern forensic pathology. This edition retains the outline format of the original, which allows for quick access and rapid assimilation. Written in no-nonsense, easily understandable language, this precise and thorough yet compact resource contains extensively detailed entries from two of the nation's foremost authorities on gunshot wounds and forensic pathology. With numerous instructional charts and diagrams and color photographs, it organizes a wealth of instructional and immediately applicable information. Features of the second edition include a chapter on nursing home death, added information on gunshot residue, and research on tasers, pepper spray, and excited delirium syndrome. Introducing medicolegal casework and documentation, this book explains protocols for the collection and recovery of evidence and DNA analysis and lists factors used to determine time of death and identity of the deceased. It identifies the natural causes of death in children and adults before devoting the remaining chapters to the myriad of non-natural causes including homicide, suicide, accidental, and undetermined. With meticulous detail and instant access to extensive information, this handbook is an indispensable tool for forensic pathologists, law enforcement, and legal personnel, as well as pathologists in training.

This third volume in the Forensic Pathology Atlases: Causes of Death Series provides an overview of the types, mechanisms, and physical findings associated with deaths involving asphyxia. Asphyxia and Drowning serves as a basic framework for an extensive pictorial representation of findings associated with these types of deaths. It helps the reader to gain a better understanding of the processes leading to asphyxiation, to recognize the associated physical findings, and better appreciate the difficulties in evaluating asphyxiation deaths.

The composition of portfolios is one of the most fundamental and important methods in financial engineering, used to control the risk of investments. This book provides a comprehensive overview of statistical inference for portfolios and their various applications. A variety of asset processes are introduced, including non-Gaussian stationary processes, nonlinear processes, non-stationary processes, and the book provides a framework for statistical inference using local asymptotic normality (LAN). The approach is generalized for portfolio estimation, so that many important problems can be covered. This book can primarily be used as a reference by researchers from statistics, mathematics, finance, econometrics, and genomics. It can also be used as a textbook by senior undergraduate and graduate students in these fields.

An estimated 1 in 20 patients are admitted to the hospital due to problems with their medication and 1 in 100 hospitalized patients are harmed due to medication errors during their stay. The prescribing of medications is the most common health care intervention and medication safety is relevant to all health care professionals and patients, in all health care settings. Safety in Medication Use provides an overview of the theory and practice of medication safety, summarizing the international literature and practical suggestions for local practice Each chapter is written by one or more authors from around the world who were chosen because of their standing in their field. The book covers three broad areas: problems in the medication use process, approaches to understanding and resolving them, and putting solutions into practice. Topics discussed include: Measuring medication errors Improvement science Safety culture Incident reporting and feedback approaches Educational interventions Communication between health care professionals Interventions for safer work systems Electronic prescribing and medication administration record systems Innovations in dispensing Patient involvement in medication safety Each chapter is a primer on the topic, drawing on the international literature, with the chapters on solutions followed by an "expert summary" of the implications for practice. This valuable resource describes an international body of work that shows not only how widespread medication errors are, but also discusses interventions that can reduce such errors to improve patient safety.

This book covers several of the statistical concepts and data analytic skills needed to succeed in data-driven life science research. The authors proceed from relatively basic concepts related to computed p-values to advanced topics related to analyzing highthroughput data. They include the R code that performs this analysis and connect the lines of code to the statistical and mathematical concepts explained.

Officer-Involved Shootings and Use of Force: Practical Investigative Techniques, Second Edition continues to provide sound and sober models, protocols, and procedures to handle the highly charged fall-out from officer involved shootings. Written by cops for cops, it is designed to address the needs of the agency, the rights of the employee, and the concerns of the public, and give law enforcement the policies and tools to properly investigate and document this high profile area. Updated and expanded, the second edition welcomes contributions from Randy Dickson, one of the nation's leading experts, who presents new recommendations for post-incident support and the emotional aspect of these traumatic events, including the potential for Post Traumatic Stress Disorder suffered by the officer. Other new chapters include a study of incidents involving less lethal weapons, such as Tasers, a model policy for documenting these incidents, and the latest findings on positional asphyxia and Excited Delirium Deaths. The book also includes additional information on report writing and the proper handling of media and public information policy. The author offers expert tips on procedures including handling suspects, interviewing witnesses and employees, and investigating the scene, as well as critical points for working with assisted suicides. New, up-to-date case studies illustrate and explain the need for consistent, reliable protocols to protect the agency, the officer, and the public from unnecessary litigation, public distrust, media frenzy, and harm to either the agency's or the officer's reputation. Applicable to all levels including city, county, state, and federal law enforcement, thisSecond Editioncontains anoutstanding presentation of guidelines, authority, and assignment responsibility to establish the best organizational team structure to investigate [officer-involved] shootings, says Larry Moore, Certified Emergency Manager, Knoxville, Ten

It fills a void in the resources available to researchers and practitioners in forensic hair examination by providing photographic archetypes for the microscopic characteristics of human hair and the variates of the characteristics seen in forensic examinations, including curl; color; pigment distribution and density; cortical fusi; and ovoid bodies. These illustrations provide a uniform basis for describing the characteristics and their variations for forensic professionals in differing geographical areas. The documentation of hair characteristics using the scoring system outlined in this atlas allows researchers to develop data regarding the frequency of characteristics within the hairs of one or more individuals and the assessment of whether certain hair characteristics are co-dependent.

An introductory text for students taking a first course in statistics-in fields as diverse as engineering, business, chemistry, and biology-Essential Statistics: Fourth Edition thoroughly updates and enhances the hugely successful third edition. It presents new information on modern statistical techniques such as Analysis of Variance (ANOVA), and software such as MINITAB for WINDOWS. An experienced former lecturer, the author communicates to students in his trademark easy-to-follow style. Keeping complex mathematical theory to a minimum, Rees presents a wealth of fully explained worked examples throughout the text. In addition, the end-of-chapter Worksheets relate to a variety of fields-enabling students to see the relevance of the numerous methods to their study areas. Essential Statistics: Fourth Edition emphasizes the principles and assumptions underlying the statistical methods, thus providing the tools needed for students to use and interpret statistical data effectively.

Written by experts with a combined 50 years of experience teaching and researching in the field of domestic abuse, Intimate Partner Violence: Effective Procedure, Response, and Policy provides practical instruction for practitioners and lay people responding to domestic violence, as well as ideas for policymakers working to create solutions to the violence. Narratives by victims of intimate partner abuse provide a framework from which students and practitioners can assess address problems of domestic abuse. This book focuses on what can be practically done to address the problem of domestic violence for individual practitioners as well as policymakers, lawmakers, and criminal justice practitioners.

Parasitology Highly detailed textbook on parasites and parasite relationships The fully revised edition of Parasitology: An Integrated Approach holds true to its engaging and easy-to-read approach. It comprehensively covers the complex and dynamic interaction between the parasite and its host ranging from invertebrates to vertebrates. Following an integrated approach, the authors explain how the study of parasites requires an understanding of biological concepts such as growth and reproduction, molecular biology, biochemistry, immunology, and pathology. In this second edition, they further address parasites and parasite relationships in the grand scheme of global changes and their impact. This textbook also reviews the often-neglected positive aspects of parasite infections and how humans have used parasites for their own advantage. Parasitology: An Integrated Approach, 2nd edition includes supplementary learning resources such as self-assessment quizzes, practical exercises, and an extensive collection of photographs. Now includes parasite life cycles in colour Strong focus on parasite interactions with other pathogens such as bacteria and viruses Discusses major advancements in the field of parasite diagnostics Additional image material and learning resources (quizzes, practical exercises) provided online A valuable and comprehensive learning resource for undergraduate students in the biological, biomedical and veterinary sciences and in medicine. It is also of interest to postgraduates and professionals with an interest including but not limited to parasitology, animal welfare, ecology, and medical microbiology.

This book focuses on a diverse range of disciplines, including pharmacy, sociology, social policy, psychology, anthropology, history and health economics, with contributors each bringing a unique perspective and insight into the practice of pharmacy.

We have previously described the syntheses of both magnetic and nonmagnetic polymeric microspheres, and we have reported their application in removal of neuroblastoma cells from normal cells in bone marrow, in the separation of red blood cells, and the separation of human B and T lymphocytes. In the present study, we describe a series of hydrophilic microspheres consisting of (1) poly-HEMA and (2) a copolymer sequence of HEMA-acrolein microspheres.

Covering one of the most important research topics in cancer biology, this is an ideal ready reference for oncologists, cell biologists, pharmaceutists, pathologists, molecular biologists, internists, and researchers working in the pharmaceutical industry.
Following an introduction that provides an overview of tumor angiogenesis, the book goes on to look at mechanisms of angiogenesis and lymphangiogenesis, signal transduction, therapeutic approaches in combination with established treatments, and concludes with a section on imaging and biomarkers in angiogenesis.

In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design. Its main aims are to introduce the theoretical framework and algorithms, discuss the range of validity, strengths and limitations of each methodology, and present applications to real world problems in the drug discovery arena. Special emphasis has been given to the emerging and most pressing methodological challenges in in silico drug discovery and design. The book assumes a basic knowledge of physical principles and molecular modeling. Particular attention has been paid to outline the underlying physico-chemical foundation of the methods described, thus providing the necessary background to avoid a "black-box" approach. In each self-contained chapter, this is presented together with the latest developments and applications, and the challenges that lie ahead. Assembling a unique team of experts to weigh in on the most important issues influencing modern computational drug discovery and design, this book constitutes both a desktop reference to academic and industrial researchers in the field, and a textbook for students in the area of molecular modeling and drug discovery. Comprised of 18 chapters and divided into three parts, this book: Provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design Outlines the underlying physico-chemical foundation of the methods described Presents several applications of computational methods to real world problems in the drug design field Helps to avoid a "black-box" approach to in silico drug discovery Constitutes an actual textbook for students in the area of molecular modeling and drug discovery Gives the reader the adequate background to face the current challenges of the field In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications describes the theoretical framework, methods, practical applications and case examples relevant to computer-aided drug lead discovery and design. This text will surely aid in understanding the underlying physical foundation of computational tools and their range of application, thus facilitating the interpretation of simulation results.

Nature converts molecules into edible structures, most of which are then transformed into products in factories and kitchens. Tasty food structures enter our mouths and different sensations invade our bodies. By the time these structures reach our cells, they have been broken back down into molecules that serve as fuel and raw materials for our bodies. Drawing from the physical and engineering sciences, food technology, nutrition, and gastronomy, Edible Structures: The Basic Science of What We Eat examines the importance of food structures the supramolecular assemblies and matrices that are created by nature and when we cook rather than the basic chemical compounds that are the more traditional focus of study. The central objectives of this book are to address the pressing food trends of this century, including: Growing evidence that flavorful food structures are important for the delivery of the nutritious and healthful food molecules from which they are made A need to understand and control how food structures are created and presented as products that respond to nutritional requirements Opportunities to design certain foods to better suit the needs of modern lifestyles The empowerment of consumers and the appearance of the axis that connects the food we eat with our brain, digestive system, and the cells in our body The separation between a knowledgeable gourmet "elite" and the rest of the population who simply want to eat quick meals as cheaply as possible Entertaining and informative, Edible Structures: The Basic Science of What We Eat uses scientific yet understandable terms throughout to facilitate the communication between experts and the educated public, especially those who are curious, love to cook and innovate in the kitchen and/or want to enjoy good food. The language and concepts presented in this book giv

Analysis of Failure and Survival Data is an essential textbook for graduate-level students of survival analysis and reliability and a valuable reference for practitioners. It focuses on the many techniques that appear in popular software packages, including plotting product-limit survival curves, hazard plots, and probability plots in the context of censored data. The author integrates S-Plus and Minitab output throughout the text, along with a variety of real data sets so readers can see how the theory and methods are applied. He also incorporates exercises in each chapter that provide valuable problem-solving experience. In addition to all of this, the book also brings to light the most recent linear regression techniques. Most importantly, it includes a definitive account of the Buckley-James method for censored linear regression, found to be the best performing method when a Cox proportional hazards method is not appropriate.Applying the theories of survival analysis and reliability requires more background and experience than students typically receive at the undergraduate level. Mastering the contents of this book will help prepare students to begin performing research in survival analysis and reliability and provide seasoned practitioners with a deeper understanding of the field.