This book is intended as an overview at an undergraduate or early university level and describes the effects of spaceflight at cellular and organism levels. Past, current, and future research on the effects of gravity - or its absence - and ionizing radiation on the evolution, development, and function of living organisms is presented in layman's terms by researchers who have been active in this field. The purpose is to enlighten science and non-science readers to the benefits of space biology research for conducting basic and applied research to support human exploration of space and to take advantage of the space environment as a laboratory for scientific, technological, and commercial research. The first chapters present an overview of the major focuses of space research in biology, as well as the history and the list of animals and plants that have flown in space to date.

Die Neuauflage dieses uberaus renommierten Lehrbuchs wurde als Antwort auf die rasanten Fortschritte in dem Fachgebiet vollstandig aktualisiert und prasentiert neue leistungsstarke Methoden und Konzepte in der Biotechnologie, u.a. Genome Editing, reprogrammierte Stammzellen und personalisierte Medizin. Auf eine Einfuhrung in die Grundlagen der Molekular- und Zellbiologie folgt eine Beschreibung der Standardverfahren, darunter Aufreinigung und Analyse von Biomolekulen, Verfahren der Klonierung, Gen-Expressionssysteme, Methoden des Genome Editing, Protein-Labeling und In-situ-Verfahren, Standard- und hochaufloesende Mikroskopie. Der dritte Teil legt den Schwerpunkt auf wichtige Forschungs- und Anwendungsgebiete, von der funktionalen Genomik, Proteomik und Bioinformatik bis hin zu Drug Targeting, rekombinante Antikoerper und Systembiologie. Der letzte Teil wirft einen Blick auf Unternehmen der Biotechnologie und untersucht Fragestellungen des geistigen Eigentums, den Rechtsrahmen fur pharmazeutische Produkte und das Zusammenspiel von Startup- und groesseren Unternehmen. Die Inhalte sind durchgangig uberaus ansprechend illustriert, mit Hunderten von farbigen Diagrammen und Fotos. Dieses Lehrbuch vermittelt Studenten und Berufspraktikern der Biowissenschaften, Pharmazie und Biochemie alles Wissenswerte rund um die molekulare Biotechnologie.

This book is addressed to students, researchers and academics who have barely heard of the emerging young science of Biosemiotics, and who want to know more about it. Written by many of the fielda (TM)s major contributors, it provides a highly qualified introduction to Biosemiotics and illustrates the most recent views in its background and development.

Combining research approaches from biology, philosophy and linguistics, the field of Biosemiotics proposes that animals, plants and single cells all engage in semiosis a" the conversion of objective signals into conventional signs. This has important implications and applications for issues ranging from natural selection to animal behavior and human psychology, leaving biosemiotics at the cutting edge of the research on the fundamentals of life.

Drawing on an international expertise, the book details the history and study of biosemiotics, and provides a state-of-the-art summary of the current work in this new field. And, with relevance to a wide range of disciplines a" from linguistics and semiotics to evolutionary phenomena and the philosophy of biology a" the book provides an important text for both students and established researchers, while marking a vital step in the evolution of a new biological paradigm.

Marcello Barbieri is University Professor of Embryology at the University of Ferrara, Italy, President of the Italian Association for Theoretical Biology and Editor-in-Chief of the Journal of Biosemiotics.

This dictionary is intended as a guide to the terminology used in a wide range of animal-related programmes of study including agriculture, animal care, animal management, animal production, animal welfare, veterinary nursing, wildlife conservation and zoo biology. In total it contains over 5,300 entries. It contains a wide range of terms used in the fields of veterinary science, physiology and zoology, as students whose primary interests are animal welfare or zoo biology also need to have some understanding of disease, how animal bodies function and how animals are classified. It also contains some legal terms, and reference to some legal cases, to help students understand how the protection, use and conservation of animals is regulated by the law. Some people, famous animals, literature and films have influenced the way we think about, and behave towards, animals. For this reason, the book includes references to important books about animals, famous animals who have starred in films or been the subject of scientific studies, along with short biographies of famous scientists and others who have studied animals or established conservation or animal welfare organisations.

Exam Board: AQA Level: AS/A-level Subject: Biology First Teaching: September 2015 First Exam: June 2016 Ensure your students get to grips with the core practicals and develop the skills needed to succeed with an in-depth assessment-driven approach that builds and reinforces understanding; clear summaries of practical work with sample questions and answers help to improve exam technique in order to achieve higher grades. Written by an experienced teacher, this Student Guide for practical Biology: - Help students easily identify what they need to know with a concise summary of required practical work examined in the A-level specifications. - Consolidate understanding of practical work, methodology, mathematical and other skills out of the laboratory with exam tips and knowledge check questions, with answers in the back of the book. - Provide plenty of opportunities for students to improve exam technique with sample answers, examiners tips and exam-style questions. - Offer support beyond the Student books with coverage of methodologies and generic practical skills not focused on in the textbooks.

Toby K. Eisenstein Symposium Committee Chairperson Temple University School of Medicine Philadelphia, Pennsylvania 19140 This symposium is the thirteenth biennial clinical microbiology program sponsored by the Eastern Pennsylvania Branch of the American Society for Microbiology in cooperation with the Philadelphia area medical schools and the Bureau of Laboratories of the Pennsylvania Department of Health. This year a generous contribution from Merck, Sharp and Dohme has helped to make the program a reality. The subject matter for this symposium represents an attractive spectrum of medical, biological and molecular approaches to the practical solution of a public health prob1em--name1y, prevention of infection with the hepatitis B virus. The symposium may be unique in that it focuses on a product which was first marketed less than three months ago, but included in the program are presen tations on two new approaches to hepatitis B vaccine production which may replace the one which is newly unveiled. The rapidity of progress in our present era of biological research is indeed astonishing."

A knowledge of how plants have responded to environmental change in the past is our principal source of evidence for predicting how they might respond to the new environments of the future and a knowledge of past climates may enable us to assess more clearly the human contribution to the climatic changes of the future. This book aims to present the results of investigations into the history of the world's plant cover over the last 65 million years, not the methods by which these results have been achieved, and to document a selection of published accounts, both general and specific, for further reading. The book is organized into four main sections, dealing successively with the tenet that modern plant distributions and communities have been moulded by long-term environmental change, the nature of global environmental change over the last 65 million years, the ways in which plants and plant communities have responded to environmental change, and the global history of forest, dryland and coldland communities over the last 65 million years. The final chapter considers the future.

During the last two decades, structural equation modeling (SEM) has emerged as a powerful multivariate data analysis tool in social science research settings, especially in the fields of sociology, psychology, and education. Although its roots can be traced back to the first half of this century, when Spearman (1904) developed factor analysis and Wright (1934) introduced path analysis, it was not until the 1970s that the works by Karl Joreskog and his associates (e. g., Joreskog, 1977; Joreskog and Van Thillo, 1973) began to make general SEM techniques accessible to the social and behavioral science research communities. Today, with the development and increasing avail ability of SEM computer programs, SEM has become a well-established and respected data analysis method, incorporating many of the traditional analysis techniques as special cases. State-of-the-art SEM software packages such as LISREL (Joreskog and Sorbom, 1993a, b) and EQS (Bentler, 1993; Bentler and Wu, 1993) handle a variety of ordinary least squares regression designs as well as complex structural equation models involving variables with arbitrary distributions. Unfortunately, many students and researchers hesitate to use SEM methods, perhaps due to the somewhat complex underlying statistical repre sentation and theory. In my opinion, social science students and researchers can benefit greatly from acquiring knowledge and skills in SEM since the methods-applied appropriately-can provide a bridge between the theo retical and empirical aspects of behavioral research."

This volume discusses the vaccine development process and the role delivery concepts contribute to a global goal of effective health outcomes. The chapters in this book cover a wide range of topics such as antigen discovery methods; genetic and protein antigen preparation; preparation of viral vaccines as VLPs; viral and non-viral gene delivery; needle-less or non-invasive delivery technology; vaccine storage; and vaccine administration and assessment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics; lists of the necessary materials and reagents; step-by-step, readily reproducible laboratory protocols; and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Vaccine Delivery Technology: Methods and Protocols is a valuable resource for both novice and expert researchers, in and outside the field, who would like to gain insight into the impactful field of vaccines. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Quantities, Symbols, Units, and Abbreviations in the Life Sciences is a reliable compilation of the most up-to-date recommendations for using units, symbols, abbreviations, and acronyms in scientific publications across the biological sciences. Drawing on the authority of the various nomenclature committees of the many international societies in the biosciences, as well as on the editors of prestigious scientific journals, and on eminent individuals active in scientific publishing, this essential reference provides authors and editors with easy access to the authoritative usage of the universally accepted terms they need for clear scientific communication. The compiled symbols, units, and abbreviations are defined, with commentary and some etymological background frequently provided. The diverse scope of disciplines treated includes biochemistry, molecular biology, medicine, genetics, immunology, and virology, plus appropriate sections on mathematics, physics, and chemistry.

Coding, Shaping, Making combines inspiration from architecture, mathematics, biology, chemistry, physics and computation to look towards the future of architecture, design and art. It presents ongoing experiments in the search for fundamental principles of form and form-making in nature so that we can better inform our own built environment. In the coming decades, matter will become encoded with shape information so that it shapes itself, as happens in biology. Physical objects, shaped by forces as well, will begin to design themselves based on information encoded in matter they are made of. This knowledge will be scaled and trickled up to architecture. Consequently, architecture will begin to design itself and the role of the architect will need redefining. This heavily illustrated book highlights Haresh Lalvani's efforts towards this speculative future through experiments in form and form-making, including his work in developing a new approach to shape-coding, exploring higher-dimensional geometry for designing physical structures and organizing form in higher-dimensional diagrams. Taking an in-depth look at Lalvani's pioneering experiments of mass customization in industrial products in architecture, combined with his idea of a form continuum, this book argues for the need for integration of coding, shaping and making in future technologies into one seamless process. Drawing together decades of research, this book will be a thought-provoking read for architecture professionals and students, especially those interested in the future of the discipline as it relates to mathematics, science, technology and art. It will also interest those in the latter fields for its broader implications.

The modern developments in mathematical biology took place roughly between 1920 and 1940, a period now referred to as the "Golden Age of Theoretical Biology." The eminent Italian mathematician Vito Volterra played a decisive and widely acknowledged role in these developments. Volterra's specific project was to transfer the model and the concepts of classical mechanics to biology, constructing a sort of "rational mechanics" and an "analytic mechanics" of biological associations. The new subject was thus to be equipped with a solid experimental or at least empirical basis, also in this case following the tried and tested example of mathematical physics. Although very few specific features of this reductionist programme have actually survived, Volterra's contribution was decisive, as is now universally acknowledged, in encouraging fresh studies in the field of mathematical biology. Even today, the primary reference in the literature of the field of population dynamics consists of Volterra's work and the descriptive schemata (the "models," in modern parlance) he proposed. The present book aims to fill this historiographic gap by providing an exhaustive collection of the correspondence between Volterra and numerous other scientists on the topic of mathematical biology. The book begins with an introductory essay by Ana MillAn Gasca, which aims at giving a picture of the research field of biomathematics in the "Golden Age," and shows the importance of the correspondence in this context. This is followed by a transcript of the correspondence ordered by the correspondent's name. Each item is preceded by a biographical profile of the correspondent and accompanied by notes containing informationand references to facilitate understanding. The book will be found useful not only by science historians but also by all those - in particular, biomathematicians and biologists - with an interest in the origins of and events in a branch of learning that has undergone an astonishing development. Many of the problems discussed - in particular that of empirical verification - appear extremely topical even today and in some cases could even fuel reflection on topics still open to research.

This graduate-level text provides a survey of the logic and reasoning underpinning statistical analysis, as well as giving a broad-brush overview of the various statistical techniques that play a major roll in scientific and social investigations. Arranged in rough historical order, the text starts with the ideas of provability that underpin statistical methods and progresses through the developments of the nineteenth and twentieth centuries to modern concerns and solutions. Assuming only a basic level of Mathematics and with numerous examples and illustrations, this text presents a valuable resource not only to the experienced researcher but also to the student, by complementing courses in a wide range of substantive areas and enabling the reader to rise above the details in order to see the overall structure of the subject.

Exam Board: Edexcel Level: A level Subject: Science / Biology First teaching: September 2015 First exams: June 2017 An ActiveBook is included with every Student Book, giving your students easy online access to the content in the Student Book. They can make it their own with notes, highlights and links to their wider reading. Perfect for supporting work and revision activities. Student Book 1 supports a standalone AS course and provides the first year of a two-year A level course; Student Books 1 and 2 together support the full A level course. A cumulative approach to learning constantly builds on what has previously been taught. The chapter openers highlight prior learning requirements and link to future learning. The required maths skills are highlighted at the start of each chapter providing opportunities for students to check understanding and remedy gaps. Bigger spreads require students to read real-life material that's relevant to the course and use knowledge in new contexts. Accompanying questions require students to analyse how scientists write, think critically and consider issues. Preparing for your exams sections highlight the key differences between preparing for an AS and full A level exam. Practice question spreads provide opportunities for students to regularly check their understanding using questions written in the style of the new exams from day one.

This revised and updated second edition is an accessible companion designed to help science and technology students develop the knowledge, skills and strategies needed to produce clear and coherent academic writing in their university assignments. Using authentic texts to explore the nature of scientific writing, the book covers key areas such as scientific style, effective sentence and paragraph structure, and coherence in texts and arguments. Throughout the book, a range of tasks offers the opportunity to put theory into practice. The explorative tasks allow you to see how language works in a real scientific context, practice and review tasks consolidate learning and help you to develop your own writing skills, and reflective tasks encourage you to think about your own knowledge and experience, and bring this to bear on your own writing journey at university. Key features of the new edition include: * Updated content and additional tasks throughout * New chapters, covering writing in the sciences and writing at university * The introduction of reflective tasks * Up-to-date examples of authentic scientific writing Clear, engaging and easy-to-use, this is an invaluable tool for the busy science or technology student looking to improve their writing and reach their full academic potential.

Agent-based modeling is a new technique for understanding how the dynamics of biological, social, and other complex systems arise from the characteristics and behaviors of the agents making up these systems. This innovative textbook gives students and scientists the skills to design, implement, and analyze agent-based models. It starts with the fundamentals of modeling and provides an introduction to NetLogo, an easy-to-use, free, and powerful software platform. Nine chapters then each introduce an important modeling concept and show how to implement it using NetLogo. The book goes on to present strategies for finding the right level of model complexity and developing theory for agent behavior, and for analyzing and learning from models. Agent-Based and Individual-Based Modeling features concise and accessible text, numerous examples, and exercises using small but scientific models. The emphasis throughout is on analysis--such as software testing, theory development, robustness analysis, and understanding full models--and on design issues like optimizing model structure and finding good parameter values. * The first hands-on introduction to agent-based modeling, from conceptual design to computer implementation to parameterization and analysis* Provides an introduction to NetLogo with nine chapters introducing an important modeling concept and showing how to implement it using NetLogo * Filled with examples and exercises, with updates and supplementary materials at http://www.railsback-grimm-abm-book.com/ * Designed for students and researchers across the biological and social sciences * Written by leading practitioners Leading universities that have adopted this book include: * Amherst College * Brigham Young University * Carnegie Mellon University* Cornell University * Miami University * Northwestern University * Old Dominion University * Portland State University * Rhodes College * Susquehanna University * University College, Dublin * University of Arizona* University of British Columbia* University of Michigan * University of South Florida* University of Texas at Austin * University of Virginia

This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases.Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research.

Sedert die tweede druk van die tweede uitgawe in 1975 was Die siel van die mier egter slegs as ’n skaars tweedehandse eksemplaar beskikbaar. Hierdie uitgawe is verryk deur ’n inleidende besinning oor die vraag of Maeterlinck, die Belgiese Nobelpryswenner, Marais se teorie oor die termietnes as organiese eenheid oorgeneem het. Origens blyk dit uit die verskillende drukke en uitgawes hoe Afrikaans in die jare twintig van die twintigste eeu nog op weg was om ’n wetenskaplike woordeskat te vind en die addendum bevat artikels wat vandag slegs met moeite uit ou tydskrifte en koerante opgediep kan word.

The Psychology of Death Investigations outlines definitively how behavioral evidence can often provide the necessary components and "missing pieces" to complement physical evidence as an essential tool for incident reconstruction. In order to determine the direction of an investigation and to prioritize leads, if necessary, death investigators must establish the manner of a death: natural, accident, homicide or suicide. The most overlooked aspect of death investigation is the psychological dimension, which can provide unique leads, correct false assumptions, enhance investigative awareness, and solve cases in surprising ways. In an estimated 10-20% of cases, the manner of death cannot be determined, or worse, has been erroneously categorized. Since many jurisdictions can't afford behavioral consultants, this book has been written to provide practical information for a basic psychological analysis. If the circumstances surrounding a death are equivocal, psychological consultants can compile information retrospectively about a deceased person's mental state and possible motive to assist with unravelling ambiguity about the manner of death. This is the primary function of a psychological autopsy, and, as such, this is the first book of its kind dedicated solely to the topic. In the event that the manner of death is determined to be a homicide, behavioral profiling can help to focus the potential pool of suspects. Professionals and students alike will benefit from the exercise of cognitive awareness and the application of psychological logic presented. Psychologists, medical examiners, coroners, attorneys, fraud examiners, law enforcement personnel, death and homicide investigators, and students enrolled in criminal profiling, forensic psychology, and criminal justice programs will find this text to be a compelling and insightful reference to add to their professional toolkit.