Sedert die tweede druk van die tweede uitgawe in 1975 was Die siel van die mier egter slegs as ’n skaars tweedehandse eksemplaar beskikbaar. Hierdie uitgawe is verryk deur ’n inleidende besinning oor die vraag of Maeterlinck, die Belgiese Nobelpryswenner, Marais se teorie oor die termietnes as organiese eenheid oorgeneem het. Origens blyk dit uit die verskillende drukke en uitgawes hoe Afrikaans in die jare twintig van die twintigste eeu nog op weg was om ’n wetenskaplike woordeskat te vind en die addendum bevat artikels wat vandag slegs met moeite uit ou tydskrifte en koerante opgediep kan word.

This book presents a collection of chapters on modern bioelectrochemistry focusing on new materials for biodevice, bioelectrosynthesis and bioenergy. The chapters cover protein engineering, semiconductors, biorecognition, graphene-based bioelectronics, bioelectrosynthesis, biofuel cells, bioinspired batteries and biophotovoltaics.

This book confronts the hotly debated claim that language is a species specific trait of humans. It also considers the notion that disentangling the evolutionary history of language is one of science's hardest problems. Building on the recent conceptual breakthroughs of the EvoDevo paradigm, Balari and Lorenzo argue that language is not so exceptional after all. It is, rather, just the human version of a fairly common and conservative organic system which they call the Central Computational Complex. The authors also propose that interspecies variation of this organ is restricted to (i) accessible memory resources, and (ii) patterns of external connectivity, both being the result of perturbations on the system underlying its development. The book, written accessibly for both biologists and linguists, offers a fresh perspective on language as a naturally evolved phenomenon.

This book presents modern methods and real-world applications of compositional data analysis. It covers a wide variety of topics, ranging from an updated presentation of basic concepts and ideas in compositional data analysis to recent advances in the context of complex data structures. Further, it illustrates real-world applications in numerous scientific disciplines and includes references to the latest software solutions available for compositional data analysis, thus providing a valuable and up-to-date guide for researchers and practitioners working with compositional data. Featuring selected contributions by leading experts in the field, the book is dedicated to Vera Pawlowsky-Glahn on the occasion of her 70th birthday.

Microbiology is a comprehensive textbook that facilitates a thorough understanding of the scope, nature, and complexity of the science of microscopic organisms. It gives a balanced presentation of foundational concepts, real-world applications, and current research and experimentation. The text approaches the subject within the context of exploration and experimentation, integrating a wealth of classroom-tested pedagogical features. The material is organized around the three pillars of physiology, ecology, and genetics - helping students appreciate the interconnected and dynamic nature of microbiology and explore the relationship between different types of microbes, other organisms, and the environment. This international adaptation contains up-to-date coverage of topics including DNA replication and gene expression, viral pathogenesis, microbial biotechnology, adaptive immunity, the control of infectious diseases, and the microbiology of food and water. It also offers integrated coverage of SARS-CoV-2 and the impacts of COVID-19, relating it to the importance of an interdisciplinary response to a global pandemic. It also focuses on strengthening the organization of the content and updating the end of chapter problems

In recent years there has been rapid progress in the development of signal processing in general, and more specifically in the application of signal processing and pattern analysis to biological signals. Techniques, such as parametric and nonparametric spectral estimation, higher order spectral estimation, time-frequency methods, wavelet transform, and identifi cation of nonlinear systems using chaos theory, have been successfully used to elucidate basic mechanisms of physiological and mental processes. Similarly, biological signals recorded during daily medical practice for clinical diagnostic procedures, such as electroen cephalograms (EEG), evoked potentials (EP), electromyograms (EMG) and electrocardio grams (ECG), have greatly benefitted from advances in signal processing. In order to update researchers, graduate students, and clinicians, on the latest developments in the field, an International Symposium on Processing and Pattern Analysis of Biological Signals was held at the Technion-Israel Institute of Technology, during March 1995. This book contains 27 papers delivered during the symposium. The book follows the five sessions of the symposium. The first section, Processing and Pattern Analysis of Normal and Pathological EEG, accounts for some of the latest developments in the area of EEG processing, namely: time varying parametric modeling; non-linear dynamic modeling of the EEG using chaos theory; Markov analysis; delay estimation using adaptive least-squares filtering; and applications to the analysis of epileptic EEG, EEG recorded from psychiatric patients, and sleep EEG."

The Editors would like to thank the authors of the papers at the Advanced Research Workshops for their excellent presentations at the workshops and the production of their drafts. We are indebted to those who helped in the preparation of this volume. We should particularly like to acknowledge the help of Piers Millett, who compiled the papers, set them into camera-ready format and produced the index and Dr. Simon Whitby who made the final changes to the manuscript. Any remaining errors are, of course, our responsibility. Malcolm R. Dando Cyril Klement Marian Negut Graham S. Pearson IX ACHIEVING SECURITY BENEFITS FROM TECHNICAL COOPERATION UNDER THE BIOLOGICAL AND TOXIN WEAPONS CONVENTION GRAHAM S. PEARSON Visiting Professor of International Security, Department of Peace Studies, University of Bradford, Bradford, West Yorkshire BD7 IDP, UK 1. Background l The Biological and Toxin Weapons Convention which opened for signature in 1972 2 and entered into force in 1975 currently has 144 States Parties and 18 Signatory States Article I of the Convention is all-embracing in its complete prohibition of biological weapons stating that: Each State Party to this Convention undertakes never in any circumstances to develop, produce, stockpile or otherwise acquire or retain: (1) Microbial or other biological agents, or toxins whatever their origin or method of production, of types and in quantities that have no justification for prophylactic, protective or other peaceful purposes; (2) Weapons, equipment or means of delivery designed to use such

I Principles 1 1 Models of Systems 3 1. 1 Systems. Models. and Modeling . . . . . . . . . . . . . . . . . . . . 3 1. 2 Uses of Scientific Models . . . . . . . . . . . . . . . . . . . . . . . . 4 1. 3 Example: Island Biogeography . . . . . . . . . . . . . . . . . . . . . 6 1. 4 Classifications of Models . . . . . . . . . . . . . . . . . . . . . . . . 10 1. 5 Constraints on Model Structure . . . . . . . . . . . . . . . . . . . . . 12 1. 6 Some Terminology . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 1. 7 Misuses of Models: The Dark Side . . . . . . . . . . . . . . . . . . . 13 1. 8 Exercises . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2 The Modeling Process 17 2. 1 Models Are Problems . . . . . . . . . . . . . . . . . . . . . . . . . . 17 2. 2 Two Alternative Approaches . . . . . . . . . . . . . . . . . . . . . . 18 2. 3 An Example: Population Doubling Time . . . . . . . . . . . . . . . . 24 2. 4 Model Objectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 2. 5 Exercises . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 3 Qualitative Model Formulation 32 3. 1 How to Eat an Elephant . . . . . . . . . . . . . . . . . . . . . . . . . 32 3. 2 Forrester Diagrams . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 3. 3 Examples . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 3. 4 Errors in Forrester Diagrams . . . . . . . . . . . . . . . . . . . . . . 44 3. 5 Advantages and Disadvantages of Forrester Diagrams . . . . . . . . . 44 3. 6 Principles of Qualitative Formulation . . . . . . . . . . . . . . . . . . 45 3. 7 Model Simplification . . . . . . . . . . . . . . . . . . . . . . . . . . 47 3. 8 Other Modeling Problems . . . . . . . . . . . . . . . . . . . . . . . . 49 viii Contents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3. 9 Exercises 53 4 Quantitative Model Formulation: I 4. 1 From Qualitative to Quantitative . . . . . . . . . . . . . . . . . Finite Difference Equations and Differential Equations 4. 2 . . . . . . . . . . . . . . . . 4. 3 Biological Feedback in Quantitative Models . . . . . . . . . . . . . . . . . . . . . . . . . . 4. 4 Example Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4. 5 Exercises 5 Quantitative Model Formulation: I1 81 . . . . . . . . . . . . . . . . . . . . . . . . . . . 5. 1 Physical Processes 81 . . . . . . . . . . . . . . . 5. 2 Using the Toolbox of Biological Processes 89 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5. 3 Useful Functions 96 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5. 4 Examples 102 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5. 5 Exercises 104 6 Numerical Techniques 107 . . . . . . . . . . . . . . . . . . . . . . . 6. 1 Mistakes Computers Make 107 . . . . . . . . . . . . . . . . . . . . . . . . . . 6. 2 Numerical Integration 110 . . . . . . . . . . . . . . . . 6. 3 Numerical Instability and Stiff Equations 115 . . . . . . . . . . . . . .

This book covers classic epidemiological designs that use a reference/control group, including case-control, case-cohort, nested case-control and variations of these designs, such as stratified and two-stage designs. It presents a unified view of these sampling designs as representations of an underlying cohort or target population of interest. This enables various extended designs to be introduced and analysed with a similar approach: extreme sampling on the outcome (extreme case-control design) or on the exposure (exposure-enriched, exposure-density, countermatched), designs that re-use prior controls and augmentation sampling designs. Further extensions exploit aggregate data for efficient cluster sampling, accommodate time-varying exposures and combine matched and unmatched controls. Self-controlled designs, including case-crossover, self-controlled case series and exposure-crossover, are also presented. The test-negative design for vaccine studies and the use of negative controls for bias assessment are introduced and discussed. This book is intended for graduate students in biostatistics, epidemiology and related disciplines, or for health researchers and data analysts interested in extending their knowledge of study design and data analysis skills. This book Bridges the gap between epidemiology and the more mathematically oriented biostatistics books. Assembles the wealth of epidemiological knowledge about observational study designs that is scattered over several decades of scientific publications. Illustrates the performance of methods in real research applications. Provides guidelines for implementation in standard software packages (Stata, R). Includes numerous exercises, covering simple mathematical proofs, consideration of proposed or published designs, and practical data analysis.

This unique collection highlights the central role played by modeling in general, and the modeling of mechanical considerations that have an effect on living matter. The volume collects several survey papers by actively working specialists, dealing with some of the most important problems both theoretical and practical in biomechanics. Written in a user-friendly style, these papers clearly explain both the biomedical and mechanical backgrounds associated with complex phenomena. This book may be used in interdisciplinary introductory courses covering various biomechanical topics for graduate students in applied mathematics, engineering, and biomedicine.

"RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects"--Provided by publisher.

Practical Analysis and Reconstruction of Shooting Incidents, Second Edition presents a holistic approach to shooting incident analysis and reconstruction, covering the entire spectrum of related sub-disciplines of forensic science. The book reviews basic firearm design and function, ammunition components, and terminology, explaining what constitutes pertinent evidence and appropriate results relative to autopsies, forensic laboratory analysis, and reenactments. The second edition features numerous additions including: Four new chapters Complete and extensive updates to all 16 original chapters Three case studies contributed by renowned professionals in the field New and revised exercises at the ends of chapters, with answers provided An expanded glossary of terminology Nearly 340 figures and illustrations, with several in full color New and updated references and suggested readings Appendices containing relevant terminology, checklists, and other resources The book details the mathematics of shooting reconstruction in clear, precise language that allows readers-both those with and without extensive science backgrounds-to apply a logical thought process to the evaluation of shooting scene evidence in order to establish the probable related events to the shooting incident. This new edition provides up-to-date information for field investigators to recognize, preserve, document, and interpret the physical evidence typically found after shooting incidents. In addition to the hundreds of illustrations, the book uses both case studies and step-by-step outlines to clearly describe the required analytical processes involved in reconstructing and interpreting shooting incident scenes.

Why is life the way it is? Bacteria evolved into complex life just once in four billion years of life on earth-and all complex life shares many strange properties, from sex to ageing and death. If life evolved on other planets, would it be the same or completely different? In The Vital Question, Nick Lane radically reframes evolutionary history, putting forward a cogent solution to conundrums that have troubled scientists for decades. The answer, he argues, lies in energy: how all life on Earth lives off a voltage with the strength of a bolt of lightning. In unravelling these scientific enigmas, making sense of life's quirks, Lane's explanation provides a solution to life's vital questions: why are we as we are, and why are we here at all? This is ground-breaking science in an accessible form, in the tradition of Charles Darwin's The Origin of Species, Richard Dawkins' The Selfish Gene, and Jared Diamond's Guns, Germs and Steel.

For CXC students who want to prepare fully for their exams, CXC Study Guides are a series of titles that provide students with additional support to pass the exam. CXC Study Guides are a unique product that have been written by experienced examiners at CXC and carry the board's exclusive branding.

In his beautifully written prose, Dr Jonathan Reisman - physician, adventure traveller and naturalist - allows readers to navigate their insides like an explorer discovering a new world. Through his offbeat adventures in healthcare and travel, Reisman discovers new perspectives on the body: a trip to the Alaskan Arctic reveals that fat is not the enemy, but the hero; a stint in the Himalayas uncovers the boundary where the brain ends and the mind begins; and eating a sheep's head in Iceland offers a lesson in empathy. By relating his experiences in far-flung lands and among unique cultures back to the body's inner workings, he shows how our organs live inextricably intertwined lives in an internal ecosystem that reflects the natural world around us. Reisman's unique perspective on the natural world and his expert wielding of wit ultimately helps us make sense of our lives, our bodies and our world in a way readers have never before imagined. 'An elegant, elegiac, and deeply enjoyable meander through human anatomy . . . the images Reisman conjures will linger long after you've devoured his delightful prose.' - Nicola Twilley, co-author of Until Proven Safe and co-host of Gastropod podcast

The Psychology of Death Investigations outlines definitively how behavioral evidence can often provide the necessary components and "missing pieces" to complement physical evidence as an essential tool for incident reconstruction. In order to determine the direction of an investigation and to prioritize leads, if necessary, death investigators must establish the manner of a death: natural, accident, homicide or suicide. The most overlooked aspect of death investigation is the psychological dimension, which can provide unique leads, correct false assumptions, enhance investigative awareness, and solve cases in surprising ways. In an estimated 10-20% of cases, the manner of death cannot be determined, or worse, has been erroneously categorized. Since many jurisdictions can't afford behavioral consultants, this book has been written to provide practical information for a basic psychological analysis. If the circumstances surrounding a death are equivocal, psychological consultants can compile information retrospectively about a deceased person's mental state and possible motive to assist with unravelling ambiguity about the manner of death. This is the primary function of a psychological autopsy, and, as such, this is the first book of its kind dedicated solely to the topic. In the event that the manner of death is determined to be a homicide, behavioral profiling can help to focus the potential pool of suspects. Professionals and students alike will benefit from the exercise of cognitive awareness and the application of psychological logic presented. Psychologists, medical examiners, coroners, attorneys, fraud examiners, law enforcement personnel, death and homicide investigators, and students enrolled in criminal profiling, forensic psychology, and criminal justice programs will find this text to be a compelling and insightful reference to add to their professional toolkit.

Intended for those who train and handle cadaver dogs, this book also encompasses information for those who work closely with them, such as police, death investigators, and anthropologists. Its interdisciplinary approach is useful to any member of a forensic team who regularly participates in or evaluates the results of the human remains search effort. Cadaver Dog Handbook sets out the principles and procedures for the training and handling of dogs for the location of human remains. It explains scent theory and its applications, introduces basic training and searching strategies/tactics, and covers the legal and taphonomic issues associated with dog searches. Intended for those who train and handle cadaver dogs, this book also encompasses information for those who work closely with them, such as police, death investigators, and anthropologists. Its interdisciplinary approach is useful to any member of a forensic team who regularly participates in or evaluates the results of the human remains search effort.

Exam Board: WJEC, Eduqas Level: AS/A-level Subject: Biology First Teaching: September 2015 First Exam: Summer 2016 Reinforce students' understanding throughout their course with clear topic summaries and sample questions and answers to help your students target higher grades. Written by experienced teacher Andy Clarke, our Student Guides are divided into two key sections, content guidance and sample questions and answers. Content guidance will: - Develop students' understanding of key concepts and terminology; this guide covers biodiversity and physiology of body systems. - Consolidate students' knowledge with 'knowledge check questions' at the end of each topic and answers in the back of the book. Sample questions and answers will: - Build students' understanding of the different question types, so they can approach each question with confidence. - Enable students to target top grades with sample answers and commentary explaining exactly why marks have been awarded.

Presents algorithmic techniques for solving problems in bioinformatics, including applications that shed new light on molecular biology

This book introduces algorithmic techniques in bioinformatics, emphasizing their application to solving novel problems in post-genomic molecular biology. Beginning with a thought-provoking discussion on the role of algorithms in twenty-first-century bioinformatics education, Bioinformatics Algorithms covers:

General algorithmic techniques, including dynamic programming, graph-theoretical methods, hidden Markov models, the fast Fourier transform, seeding, and approximation algorithms

Algorithms and tools for genome and sequence analysis, including formal and approximate models for gene clusters, advanced algorithms for non-overlapping local alignments and genome tilings, multiplex PCR primer set selection, and sequence/network motif finding

Microarray design and analysis, including algorithms for microarray physical design, missing value imputation, and meta-analysis of gene expression data

Algorithmic issues arising in the analysis of genetic variation across human population, including computational inference of haplotypes from genotype data and disease association search in case/control epidemiologic studies

Algorithmic approaches in structural and systems biology, including topological and structural classification in biochemistry, and prediction of protein-protein and domain-domain interactions

Each chapter begins with a self-contained introduction to a computational problem; continues with a brief review of the existing literature on the subject and an in-depth description of recent algorithmic and methodological developments; and concludes with a brief experimental study and a discussion of open research challenges. This clear and approachable presentation makes the book appropriate for researchers, practitioners, and graduate students alike.