Knowledge of the three-dimensional structure of a protein is absolutely required for the complete understanding of its function. The spatial orientation of amino acids in the active site of an enzyme demonstrates how substrate specificity is defined, and assists the medicinal chemist in the design of s- cific, tight-binding inhibitors. The shape and contour of a protein surface hints at its interaction with other proteins and with its environment. Structural ana- sis of multiprotein complexes helps to define the role and interaction of each individual component, and can predict the consequences of protein mutation or conditions that promote dissociation and rearrangement of the complex. Determining the three-dimensional structure of a protein requires milligram quantities of pure material. Such quantities are required to refine crystallization conditions for X-ray analysis, or to overcome the sensitivity limitations of NMR spectroscopy. Historically, structural determination of proteins was limited to those expressed naturally in large amounts, or derived from a tissue or cell source inexpensive enough to warrant the use of large quantities of cells. H- ever, with the advent of the techniques of modern gene expression, many p- teins that are constitutively expressed in minute amounts can become accessible to large-scale purification and structural analysis.

This book contains contributions from leading researchers in biomechanics, nanomechanics, tribology, contact mechanics, materials science and applications on various experimental techniques including atomic force microscopy (AFM) for studying soft, biomimetic and biological materials and objects. Biologists, physicists, researchers applying methods of contact mechanics and researchers testing materials using indentation techniques along with many other applied scientists will find this book a useful addition to their libraries. Moreover, several reviews in this book are written as introductions to several important and rather sophisticated research areas such as depth-sensing indentation, studying of biological cells by AFM probes, mechanics of adhesive contact and contact between viscoelastic (hereditary elastic) solids. The book containing new theoretical models, results of experimental studies and numerical simulations, along with reviews of above mentioned areas of contact mechanics in application to biological systems, would be beneficial for researchers in many areas of biology, medicine, engineering, mechanics and biomimetics.

A comprehensive review of the challenges that exist in patient accessibility to advanced therapy medicinal products (ATMPs), presenting clinical trials, marketing authorization, HTA, pricing, reimbursement, affordability, payment and partnership agreements of RMs and commercialisation. Specfically, we investigated how COVID-19 has impacted the RMs industry by elaborating on the disruptions it caused but also the new opportunities it brought. The ultimate goal of this work is to make strategic recommendations for manufacturers and decisions-markers on effective strategies to address the above obstacles and facilitate patient access to promising regenerative medicines. Features : Regenerative medicine (RM) is an emerging interdisciplinary field aiming to replace or regenerate human cells, tissues, or organs in order to restore normal functions. Regenerative medicine holds the promise of revolutionising treatment in the 21st century. RMs bring new hope for some previously untreatable diseases, as well as holding promise for the treatment of common chronic diseases. Rapid advancements in biotechnology and improved understanding of disease pathophysiology have attracted tremendous interests in the development of RMs. Discusses the high cost of RMs which may challenge the sustainability of healthcare insurers (public and private).

Investigating Sexual Assault Cases, Second Edition serves as an essential textbook for courses in investigating rape and sexual assault. As with the first edition, this second edition includes the latest research and techniques in coverage of victimology, offender typology, investigative techniques, interviewing, and legal implications. This new, second edition includes chapters on child victims and molestation, sexual homicides as potentially staged events, grooming, interviewing techniques, and same-sex, elder, and special populations as victims of sexual assault. The book fills a current void in the body of literature on the topics of rape and sex crime investigation. Many previous writings, while informative, do not address all the investigative processes necessary for an investigation to be thorough and complete. By providing a fresh approach to the topic, the author aims to augment those writings and, ultimately, improving the reader' awareness by being much more attuned to the needs of-and taking investigative cures from-the victim. Key Features: Outlines the complete investigative process for sexual assault cases, from evidence collection and interviews to court and legal proceedings Addresses victims and victimology, offender typology, the importance of the investigative interviewing process, and working with attorneys Includes new chapters on grooming, sexual homicides, SAFE examinations, and child-specific interviewing techniques Added coverage looks at same-sex crimes, crimes against men, elder victims, and assault of vulnerable populations In addition to being used in coursework in Forensic Science and Criminal justice programs, Investigating Sexual Assault Cases, Second Edition will serve as an essential reference for police detectives, criminal and death investigators, legal professionals, sexual assault nurses, and those who provide health, and mental health, services to populations experiencing sexual assault.

This book brings together scientists from all over the world who have defined and developed the field of Coordination Dynamics. Grounded in the concepts of self-organization and the tools of nonlinear dynamics, appropriately extended to handle informational aspects of living things, Coordination Dynamics aims to understand the coordinated functioning of a variety of different systems at multiple levels of description. The book addresses the themes of Coordination Dynamics and Dynamic Patterns in the context of the following topics: Coordination of Brain and Behavior, Perception-Action Coupling, Control, Posture, Learning, Intention, Attention, and Cognition.

Objective establishment of the truth is the goal of any good crime scene investigator. This demands a consideration of all evidence available using proven scientific methodologies to establish objective snapshots of the crime. The majority of forensic disciplines shed light on the "who" of a crime, bloodstain pattern analysis is one of the most important disciplines to address "what" happened. Understanding the discipline, its underlying scientific basis, and how best to apply this knowledge is crucial in the investigator's quest for the truth. Internationally known experts in crime scene analysis, Tom Bevel and Ross M. Gardner explore bloodstain pattern analysis in depth, explaining what it is, how it is used, and the practical methodologies employed to achieve defensible results. Bloodstain Pattern Analysis with an Introduction to Crime Scene Reconstruction, Third Edition: Presents a specific and detailed taxonomy of bloodstain pattern characteristics Offers a full-color fold-out Decision Map to guide analysts through the classification process Uses full-color photos and diagrams to illustrate concepts Describes the theory, principles, and methodology for crime scene reconstruction Details proven, applicable scientific methodologies Emphasizes observable and reproducible results to mitigate accusations of subjectivity in evidence and testimony Provides more than 60% new or significantly revised information Offering practical advice and tips for novices and experienced professionals, this book employs clear, lucid, and reasoned scientific arguments to provide the tools to guide and focus any investigative effort. Captain Tom Bevel is a 27-year veteran of the Oklahoma City Police Department, retiring in 1996 as Commander of the Homicide, Robbery, Missing Persons, and Unsolved Homicide units. He is held in high esteem as a qualified expert in crime scene reconstruction and bloodstain pattern analysis in state, federal, and foreign courts. His knowledge and expertise as a crime scene consultant has been sought after in 45 US states and 11 foreign countries. He owns a forensic education and consulting company in his home state of Oklahoma. Ross M. Gardner retired as a Command Sergeant Major and Special Agent in 1999 after serving a total of 24 years in US Army law enforcement. Certified by the International Association for Identification as a Senior Crime Analyst for the past 16 years, Gardner is an active instructor and consultant throughout the United States in crime scene analysis, bloodstain pattern analysis, and crime scene investigation.

Biology is in the midst of a era yielding many significant discoveries and promising many more. Unique to this era is the exponential growth in the size of information-packed databases. Inspired by a pressing need to analyze that data, Introduction to Computational Biology explores a new area of expertise that emerged from this fertile field- the combination of biological and information sciences.

This introduction describes the mathematical structure of biological data, especially from sequences and chromosomes. After a brief survey of molecular biology, it studies restriction maps of DNA, rough landmark maps of the underlying sequences, and clones and clone maps. It examines problems associated with reading DNA sequences and comparing sequences to finding common patterns. The author then considers that statistics of pattern counts in sequences, RNA secondary structure, and the inference of evolutionary history of related sequences.

Introduction to Computational Biology exposes the reader to the fascinating structure of biological data and explains how to treat related combinatorial and statistical problems. Written to describe mathematical formulation and development, this book helps set the stage for even more, truly interdisciplinary work in biology.

This new volume presents an array of new and emerging techniques in the food processing sector, focusing on the extraction, encapsulation, and health benefits of bioactive Compounds. It illustrates various applications of novel food processing extraction and encapsulation techniques along with the health and safety aspects of plant-derived bioactive compounds and functional foods Some of the sustainable and green extraction techniques discussed include novel extraction techniques, such as microwave-assisted extraction (MAE), ultrasonic assisted extraction (UAE), supercritical fluid extraction (SFE), accelerated solvent extraction (ASE), and rapid solid-liquid extraction (RSLE). The volume also covers the principles and methods of encapsulation, its role and application in protection and stabilization and as a targeted delivery system for enhanced nutritional health benefits. Various encapsulation methods, such as spray drying, spray cooling/chilling, fluidized bed coating, coacervation, liposome entrapment, extrusion, inclusion complexation, etc., are discussed in detail for application in the food industry. Novel Processing Methods for Plant-Based Health Foods: Extraction, Encapsulation, and Health Benefits of Bioactive Compounds also highlights the potential of nutraceuticals and biological active compounds in human health, various sources, consumers’ acceptance, safety aspects, and their application in development of functional foods. This volume offers many tremendous applications in different areas of the food industry, including in food processing, preservation, health-promoting properties, and safety and quality evaluation of plant-based foods. The book provides a wealth of information and will be an excellent reference material for researchers, scientists, students, growers, traders, processors, industry professionals, and others on the emerging food processing approaches for extraction and encapsulation of plant-based bioactive compounds and health-promoting properties of plant-derived nutraceuticals and safety aspects in production of functional foods.

Beginning his work on the monograph to be published in English, this author tried to present more or less general notions of the possibilities of mathematics in the new and rapidly developing science of infectious immunology, describing the processes of an organism's defence against antigen invasions. The results presented in this monograph are based on the construc tion and application of closed models of immune response to infections which makes it possible to approach problems of optimizing the treat ment of chronic and hypertoxic forms of diseases. The author, being a mathematician, had creative long-Iasting con tacts with immunologists, geneticist, biologists, and clinicians. As far back as 1976 it resulted in the organization of a special seminar in the Computing Center of Siberian Branch of the USSR Academy of Sci ences on mathematical models in immunology. The seminar attracted the attention of a wide circle of leading specialists in various fields of science. All these made it possible to approach, from a more or less united stand point, the construction of models of immune response, the mathematical description of the models, and interpretation of results."

A BBC RADIO 4 BOOK OF THE WEEK An original and revelatory journey through the three-billion-year history of slime - a substance upon which we and our world depend. Slime is an ambiguous thing. It exists somewhere between a solid and liquid. It inspires revulsion even while it compels our fascination. It is a both a vehicle for pathogens and the strongest weapon in our immune system. Most of us know little about it and yet it is the substance on which our world turns. Slime exists at the interfaces of all things: between the different organs and layers in our bodies, and between the earth, water, and air in the environment. It is often produced in the fatal encounter between predator and prey, and it is a vital presence in the reproductive embrace between female and male. In this ground-breaking and fascinating book, Susanne Wedlich leads us on a scientific journey through the 3 billion year history of slime, from the part it played in the evolution of life on this planet to the way it might feature in the post-human future. She also explores the cultural and emotional significance of slime, from its starring role in the horror genre to its subtle influence on Art Nouveau. Slime is what connects Patricia Highsmith's fondness for snails, John Steinbeck's aversion to hagfish, and Emperor Hirohito's passion for jellyfish, as well as the curious mating practices of underwater gastropods and the miraculous functioning of the human gut. Written with authority, wit and eloquence, Slime brings this most nebulous and neglected of substances to life. Rich and strange... a deft cultural history of the idea of slime as well as an up-to-the-minute exegesis of its science - Daily Telegraph

Elastic and inelastic scattering in transmission electron microscopy (TEM) are important research subjects. For a long time, I have wished to systematically summarize various dynamic theories associated with quantitative electron micros copy and their applications in simulations of electron diffraction patterns and images. This wish now becomes reality. The aim of this book is to explore the physics in electron diffraction and imaging and related applications for materials characterizations. Particular emphasis is placed on diffraction and imaging of inelastically scattered electrons, which, I believe, have not been discussed exten sively in existing books. This book assumes that readers have some preknowledge of electron microscopy, electron diffraction, and quantum mechanics. I anticipate that this book will be a guide to approaching phenomena observed in electron microscopy from the prospects of diffraction physics. The SI units are employed throughout the book except for angstrom (A), which is used occasionally for convenience. To reduce the number of symbols used, the Fourier transform of a real-space function P'(r), for example, is denoted by the same symbol P'(u) in reciprocal space except that r is replaced by u. Upper and lower limits of an integral in the book are (-co, co) unless otherwise specified. The (-co, co) integral limits are usually omitted in a mathematical expression for simplification. I very much appreciate opportunity of working with Drs. J. M. Cowley and J. C. H. Spence (Arizona State University), J."

Counterfeit drugs continue to infiltrate the drug market in the United States, causing illness and death. This book addresses this issue and examines the recent trends in drug counterfeiting over the past 5-10 years. The text shows perspectives from crime lab and toxicology lab personnel and academic researchers, and includes topics such as a history of cases and issues with counterfeit drugs, trends observed in forensic labs, instrumental methods and approaches used in detecting counterfeit medicines, and policy approaches for controlling counterfeit drugs. There is a focus on ways to reduce counterfeit drugs in the market, to help improve the health and safety of people all over the world. Features : Focuses on recent (5-10) year trends in counterfeit drugs and analysis. Shows perspectives from crime lab and toxicology lab personnel and academic researchers. Focuses on drugs seized by law enforcement and approaches to reducing counterfeit medicine in the market. Discusses the detection and analysis of counterfeit drugs, and appropriate tools for combating this issue. Emphasizes the global impact of illegal medicines.

Prevention and treatment of cardiometabolic disorders by lifestyle management is the most understood and effective applications of this emerging field. The focus of this book on prediabetes, diabetes and cardiometabolic diseases is timely and will be a welcome addition to clinicians who wish to gain more knowledge and competence in the area. This book will focus on the metabolic syndrome, which is the largest non-communicable disease of our time, and lifestyle approaches that drastically reduce the risks and adverse effects of this condition. Presents a detailed review of clinical evidence and guide for implementation. Provides a toolkit to counter both the high cost of medications and the need to address metabolic disorders associated with insulin resistance early, before or simultaneous to when medications are indicated.

This book is a practical guide for individuals responsible for creating products that are safe, effective, usable, and satisfying in the hands of the intended users. The contents are intended to reduce the number of use errors involving medical devices that have led to injuries and deaths. The book presents the strong connection between user interface requirements and risk management for medical devices and instructs readers how to develop specific requirements that are sufficiently comprehensive and detailed to produce good results - a user-friendly product that is likely to be used correctly. The book's tutorial content is complemented by many real-world examples of user interface requirements, including ones pertaining to an inhaler, automated external defibrillator, medical robot, and mobile app that a patient might use to manage her diabetes. The book is intended for people representing a variety of product development disciplines who have responsibility for producing safe, effective, usable, and satisfying medical devices, including those who are studying or working in human factors engineering, psychology, mechanical engineering, biomedical engineering, systems engineering, software programming, technical writing, industrial design, graphic design, and regulatory affairs.

In this captivating book Anthony Synnott explores a subject which has been woefully ignored: our bodies. He surveys the history for thinking about the body and the senses, then focuses on specific themes: gender, beauty, the face, hair, touch, smell and sight. He concludes with a review of classical and contemporary theories of the body and the senses. Thinking about the body will never be the same after reading this book.

eBook available with sample pages: 020320154X

From the Authors' Preface The advances made in the area of controlled drug delivery during the last two decades are remarkable ....Of the many polymeric materials, biodegradable hydrogels present unique advantages and opportunities in the development of ...delivery devices....We have undertaken the challenge of putting together information relevant to biodegradable hydrogels in one place. This book covers the mechanisms of biodegradation, types of biodegradable hydrogels,chemical and physical gels, chemical and enzymatic degradation, and examples of biodegradable drug delivery systems.

This book is a cohesive guide to the available methods that can be used in population viability analysis. It is therefore extremely valuable to both the practitioner of conservation biology and the theoretical population biologist.

Originally published in 1995, The Antievolution Pamphlets of Harry Rimmer is the sixth volume in the series, Creationism in Twentieth Century America. The volume brings together original sources from the prominent evangelist and pastor Harry Rimmer. The consortium of pamphlets in this volume detail Rimmer’s antievolutionist sentiments, a notion which characterized his early writings. The pamphlets detail Rimmer’s rhetoric on evolution and science from the early part of the 20th century as he travelled across America to disseminate his writings. The works in this volume address Rimmer’s polemic on the danger posed by modern science and the consequential disassociation with religion. While Rimmer did not discount science itself, he argued for, what he termed, ‘true science’, claiming that modern science was based only in scientific opinion and not fact. As a self-proclaimed scientist, these writings take a unique view of the relationship between religion and science from this period through Rimmer’s dual nature as both scientist and pastor. This volume will be of great interest to historians of natural history, science and religion.

Originally published in 1995, The Selected Works of George McCready Price is the seventh volume in the series, Creationism in Twentieth Century America, reissued in 2021. The volume brings together the original writings and pamphlets of George McCready Price, a leading creationist of the early antievolution crusade of the 1920s. McCready Price labelled himself the ‘principal scientific authority of the Fundamentalists’ and as a self-taught scientist he enjoyed more scientific repute amongst fundamentalists of the time. This interesting and unique collection of original source material includes five of his writings between 1906 and 1924, challenging the new Darwinian theory of evolution and natural selection through his writings on the natural sciences. His literature covers the topics of evolution and biology and critiques biological arguments for evolution. He also wrote widely on geology offering his own alternative argument of ‘flood geography’ in opposition to the Darwinian theory concerning palaeontology and geology. This volume will be of interest to historians of natural history and the creationism movement, as well as scholars of religion and American history.

The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases. Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas. Key Features: Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and "WELLNESS" molecule Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals Presents flavonoid-based functional foods Discusses the flavonoid nutraceuticals market and future trends Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.

4.1.1 Demographic significance Confined populations grow more rapidly than populations from which dispersal is permitted (Lidicker, 1975; Krebs, 1979; Tamarin et at., 1984), and demography in island populations where dispersal is restricted differs greatly from nearby mainland populations (Lidicker, 1973; Tamarin, 1977, 1978; Gliwicz, 1980), clearly demonstrating the demographic signi ficance of dispersal. The prevalence of dispersal in rapidly expanding populations is held to be the best evidence for presaturation dispersal. Because dispersal reduces the growth rate of source populations, it is generally believed that emigration is not balanced by immigration, and that mortality of emigrants occurs as a result of movement into a 'sink' of unfavourable habitat. If such dispersal is age- or sex-biased, the demo graphy of the population is markedly affected, as a consequence of differ ences in mortality in the dispersive sex or age class. Habitat heterogeneity consequently underlies this interpretation of dispersal and its demographic consequences, although the spatial variability of environments is rarely assessed in dispersal studies."

Crime scene reconstruction (CSR) is today's hot topic. The immense proliferation of television, print, and electronic media directed at this area has generated significant public interest, albeit occasionally encouraging inaccurate perceptions. Practical Crime Scene Analysis and Reconstruction bridges the gap between perception and reality, helping readers understand the nature of the scientific method and teaching the proper application of its components. A proven methodology The book begins by recounting the history of crime scene analysis and exploring fundamental principles. Then the authors introduce their proven methodology, known as Event Analysis. This technique defines specific actions, discusses the order of those actions, and offers significant insight into determining what did or did not happen in the course of the incident under investigation. Using case studies and more than 200 color photos, the book demonstrates this method and how it can be used to explain clues that would otherwise be puzzling or ambiguous. Practical advice from the crime scene to the courtroom The authors show how to resolve significant questions that arise in the course of CSR through the use of an event analysis worksheet. The book also discusses crime scene protocol, bloodstain pattern analysis, gunshot investigation, and forensic pathology and the human body. The final chapters provide instruction on writing crime scene reports, discuss ethical issues, and give advice on courtroom presentation. Includes color photos demonstrating the science of CSR on: Superposition Timing and sequence Bloodstain analysis Ballistics Wound patterns