"Approximately 65% of our population is overweight and 12% are morbidly obese. This is despite more than 25 years of attempted medical management. Clearly all current efforts have failed to control this enormous problem. Could it be that we have failed to recognize the cause of the disease and therefore have misdirected our efforts?" Alfredo Fernandez, MD, FASMBS, Surgeon, Tampa, Florida Reducing obesity through bariatric surgery provides a sustainable weight loss regimen, because it restricts the size of the stomach and limits food intake. However, the surgery limits the amount of nutrients absorbed by the stomach and small intestine. This book provides a comprehensive, practical guide on pre- and post-nutrition considerations in bariatric patients. It describes surgeries including gastric bypass, lap band, and sleeve; nutrition protocols for surgery patients; pregnancy considerations- pre- and post-surgery; food consumption post-surgery; advancing healthy food intake after surgery; minimizing negative side effects; and recommendations to maintain healthy diet. This nutritional guide provides health care practitioners descriptions and answers to the many questions bariatric surgery patients need to know and ask in support group meetings and individual counseling sessions. The first chapter focuses on Selling Obesity and Food as a Cheap and Legal Drug, outlining how food advertising, portion size increases, and food frauds have contributed to the obesity crisis. New research into gut hormones, microbiome influence on obesity, firmicutes, and histamine are included, as well as pregnancy after bariatric surgery and lifestyle changes eating, sleep, hydration, stress management needed for success after surgery. Many health care practitioners will use the Post Op Discharge Diet stages of progression to explain how the patient needs to prepare for their liquid diet and overcome numerous issues like dumping syndrome, hypoglycemia, a

A number of books written by statisticians address the mathematical optimization of biological systems, but do not directly address statistical optimization. Statistical Optimization of Biological Systems covers the optimization of bioprocess systems in its entirety, devoting much-needed attention to the experimental optimization of biological systems using statistical techniques. Employing real-life bioprocess optimization problems and their solutions as examples, this book: Describes experimental design from identifying process variables to selecting a screening design, applying response surface methodology, and conducting regression modeling Demonstrates the statistical analysis and optimization of different experimental designs, the results of which are used to establish important variables and optimum settings Details the optimization techniques employed to determine optimum levels of the process variables for both single- and multiple-response systems Discusses important experimental designs, such as evolutionary operation programs and Taguchi's designs Delineates the concept of hybrid experimental design using the essence of a genetic algorithm Statistical Optimization of Biological Systems examines the complex nature of biological systems, the need for optimization, and the rationale of statistical and non-statistical optimization methods. More importantly, the book explains how to successfully apply mathematical and statistical techniques to the optimization of biological systems.

Simultaneous confidence bands enable more intuitive and detailed inference of regression analysis than the standard inferential methods of parameter estimation and hypothesis testing. Simultaneous Inference in Regression provides a thorough overview of the construction methods and applications of simultaneous confidence bands for various inferential purposes. It supplies examples and MATLAB (R) programs that make it easy to apply the methods to your own data analysis. The MATLAB programs, along with color figures, are available for download on www.personal.soton.ac.uk/wl/mybook.html Most of the book focuses on normal-error linear regression models. The author presents simultaneous confidence bands for a simple regression line, a multiple linear regression model, and polynomial regression models. He also uses simultaneous confidence bands to assess part of a multiple linear regression model with the zero function, to compare two regression models, and to evaluate more than two regression models. The final chapter demonstrates the use of simultaneous confidence bands in generalized linear regression models, such as logistic regression models. This book shows how to employ simultaneous confidence bands to make useful inferences in regression analysis. The topics discussed can be extended to functions other than parametric regression functions, offering novel opportunities for research beyond linear regression models.

Crime perpetrated by healthcare professionals is increasingly pervasive in today's hospitals and other healthcare settings. Patients, coworkers, and employers are vulnerable to exploitation, fraud, abuse, and even murder. Investigative journalist Kelly M. Pyrek interviews experts who provide accounts concerning the range of criminality lurking in the healthcare setting in Healthcare Crime: Investigating Abuse, Fraud, and Homicide by Caregivers. Examines the root causes and the opportunities The book begins by offering perspectives on how the stressors inherent in the healthcare profession can contribute to aberrant behavior by medical practitioners. It then examines breaches of patient privacy, which can easily occur in today's age of technology. Highlighting appalling cases of exploitation, the book also suggests guidelines to safeguard patient privacy. Identifies the victims most at risk, and those who are their greatest threats In a chapter on abuse and assault, the book cites psychological studies that explain the root causes of victimization. It highlights the patient populations most at risk: disabled, psychiatric, and elderly, and identifies the chief victimizers: physicians, psychiatrists, dentists, pediatricians, and nursing assistants and aides. The book also examines the types of financial fraud and theft that can be perpetrated against not only patients but also employers and government agencies, and provides expert insight on how to take preventative measures. Discusses notorious serial murders in the medical profession Providing accounts of well-known healthcare-related homicides and suspicious deaths, the book also presents insights from forensic and serial murder experts as to why these incidents occur, warning signs to watch out for, and how to conduct a proper investigation. The final chapter examines simple, straightforward strategies for improving the level of quality of care and safety provided by healthcare institutions. With greater accountability and oversight, patients can once again feel secure that their providers are embracing the maxim "Above all, do no harm."

With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.

Nutrition manuals and textbooks are usually written to meet the needs of nutritionists or would-be nutritionists. This manual has been written to meet the needs of health professionals who are not nutritionists, including physicians, nurses and pharmacists. The aim is to acquaint readers in these professions with the principles of nutrition and the application of nutrition to the better delivery of health care.

Definitive Treatment of the Numerical Simulation of Bioheat Transfer and Fluid Flow Motivated by the upwelling of current interest in subjects critical to human health, Advances in Numerical Heat Transfer, Volume 3 presents the latest information on bioheat and biofluid flow. Like its predecessors, this volume assembles a team of renowned international researchers who cover both fundamentals and applications. It explores ingenious modeling techniques and innovative numerical simulation for solving problems in biomedical engineering. The text begins with the modeling of thermal transport by perfusion within the framework of the porous-media theory. It goes on to review other perfusion models, different forms of the bioheat equation for several thermal therapies, and thermal transport in individual blood vessels. The book then describes thermal methods of tumor detection and treatment as well as issues of blood heating and cooling during lengthy surgeries. It also discusses how the enhancement of heat conduction in tumor tissue by intruded nanoparticles improves the efficacy of thermal destruction of the tumor. The final chapters focus on whole-body thermal models, issues concerning the thermal treatment of cancer, and a case study on the thermal ablation of an enlarged prostate.

""The text is well written and amply interspaced with tables so that it is very informative and not too heavy to read, which is an almost unique combination in scientific books "" -International Poultry Production, Volume 18, Number 1, and International Food Hygiene, Volume 20, Number 7

The records of human gastrointestinal illness gathered by national and international bodies concerned with matters relating to public health clearly demonstrate that "Campylobacter" spp. are the most frequently identified bacteria causing infectious intestinal disease. This new book provides up to date information about the species of "Campylobacter" most often associated with food poisoning, namely "C. jejuni" and "C. coli."

Like "Salmonella" spp., "Campylobacter" spp. are zoonotic agents. Many different domestic and wild animal, avian, and also insect reservoirs of these organisms have been identified. They are also widespread in the environment and have been found to survive in both soil and natural waters.

Part of the authors' "Practical Food Microbiology Series," which includes books covering "Listeria monocytogenes," "E. coli," "Clostridium botulinum" and "Salmonella" spp., this book again offers a practical treatment of "Campylobacter" spp., drawing on real-life cases to highlight effective means of controlling these pathogenic microorganisms in foods.

Each volume in the series has been devised to provide practical and accurate information about specific microorganisms of concern to public health. This new book includes information concerning the taxonomy of "Campylobacter" spp. and methods used for their isolation and characterisation, the illnesses caused by them, the occurrences of outbreaks of illness and their investigation, and the lessons that can be learnt from these. Also discussed are the sources of these organisms, routes by which they may contaminate foods, factors affecting their survival and growth and, importantly, means for the control of "Campylobacter" spp. and their subsequent impact on public health.
The information in this book is designed for use by those in the food industry working in manufacturing, retailing and quality assurance and those in associated professional sectors, e.g. health, and students in each of these areas. This book is an invaluable tool and essential reference for all food microbiologists.

The First Book Dedicated to This Class of Longitudinal Models Although antedependence models are particularly useful for modeling longitudinal data that exhibit serial correlation, few books adequately cover these models. By gathering results scattered throughout the literature, Antedependence Models for Longitudinal Data offers a convenient, systematic way to learn about antedependence models. Illustrated with numerous examples, the book also covers some important statistical inference procedures associated with these models. After describing unstructured and structured antedependence models and their properties, the authors discuss informal model identification via simple summary statistics and graphical methods. They then present formal likelihood-based procedures for normal antedependence models, including maximum likelihood and residual maximum likelihood estimation of parameters as well as likelihood ratio tests and penalized likelihood model selection criteria for the model's covariance structure and mean structure. The authors also compare the performance of antedependence models to other models commonly used for longitudinal data. With this book, readers no longer have to search across widely scattered journal articles on the subject. The book provides a thorough treatment of the properties and statistical inference procedures of various antedependence models.

Through nine successful editions, and for over 45 years, Biogeography: An Ecological and Evolutionary Approach has provided a thorough and comprehensive exploration of the varied scientific disciplines and research that are essential to understanding the subject. The text, noted for its clear and engaging style of writing, has been praised for its solid background in historical biogeography and basic biology, that is enhanced and illuminated by discussions of current research. This new edition incorporates the exciting changes of the recent years and presents a thoughtful exploration of the research and controversies that have transformed our understanding of the biogeography of the world. New themes and topics in this tenth edition include: Next generation genetic technologies and their use in historical biogeography, phylogeography and population genomics Biogeographical databases and biodiversity information systems, which are becoming increasingly important for biogeographical research An introduction to functional biogeography and its applications to community assembly, diversity gradients and the analysis of ecosystem functioning Updated case studies focusing on island biogeography, using the latest phylogenetic studies Biogeography: An Ecological and Evolutionary Approach reveals how the patterns of life that we see today have been created by the two great Engines of the Planet: the Geological Engine, plate tectonics, which alters the conditions of life on the planet, and the Biological Engine, evolution, which responds to these changes by creating new forms and patterns of life.

Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Biosensors in Drug Discovery Programs: Microtissue Engineering for High Throughput Screening provides the latest information - from theory to practice - on challenges and opportunities for incorporating 3D cell-based biosensors or assays in drug discovery programs. The book supplies a historical perspective and defines the problem 3D cultures can solve. It also discusses how genomics and combinatorial chemistry have changed the way drug are discovered and presents data from the literature to underscore the less-than-desirable pharmaceutical industry performance under the new paradigm. The author uses results from his lab and those of other investigators to show how 3D micro environments create cell culture models that more closely reflect normal in vivo-like cell morphology and function. He makes a case for validated biomarkers for three-dimensionality in vitro and discusses the advantages and disadvantages of promising tools in the search of these biomarkers. The book concludes with case studies of drugs that were abandoned late in the discovery process, which would have been discarded early if tested with 3D cultures. Dr. Kisaalita presents evidence in support of embracing 3D cell-based systems for widespread use in drug discovery programs. He goes to the root of the issue, establishing the 3D cell-based biosensor physiological relevance by comparing 2D and 3D culture from genomic to functional levels. He then assembles the bioengineering principles behind successful 3D cell-based biosensor systems. Kisaalita also addresses the challenges and opportunities for incorporating 3D cell-based biosensors or cultures in current discovery and pre-clinical development programs. This book makes the case for widespread adoption of 3D cell-based systems, rendering their 2D counterparts, in the words of Dr. Kisaalita "quaint, if not archaic" in the near future.

Officially, the use of biomass for energy meets only 10-13% of the total global energy demand of 140 000 TWh per year. Still, thirty years ago the official figure was zero, as only traded biomass was included. While the actual production of biomass is in the range of 270 000 TWh per year, most of this is not used for energy purposes, and mostly it is not used very efficiently. Therefore, there is a need for new methods for converting biomass into refined products like chemicals, fuels, wood and paper products, heat, cooling and electric power. Obviously, some biomass is also used as food - our primary life necessity. The different types of conversion methods covered in this volume are biogas production, bio-ethanol production, torrefaction, pyrolysis, high temperature gasifi cation and combustion. This book covers the suitability of different methods for conversion of different types of biomass. Different versions of the conversion methods are presented - both existing methods and those being developed for the future. System optimization using modeling methods and simulation are analyzed to determine advantages and disadvantages of different solutions. Many international experts have contributed to provide an up-to-date view of the situation all over the world. These global perspectives and the inclusion of so much expertise of distinguished international researchers and professionals make this book unique. This book will prove useful and inspiring to professionals, engineers, researchers and students as well as to those working for different authorities and organizations.

A thorough overview of nanobiotechnology and its place in advances in applied science and engineering, The Nanobiotechnology Handbook combines contributions from physics, bioorganic and bioinorganic chemistry, molecular and cellular biology, materials science, and medicine as well as from mechanical, electrical, chemical, and biomedical engineering to address the full scope of current and future developments. World-class experts discuss the role of nanobiotechnology in bioanalysis, biomolecular and biomedical nanotechnology, biosensors, biocatalysis and biofuel, and education and workforce development. It includes downloadable resources that contain all figures in the book. The book begins with discussions of biomimetic nanotechnology, including a comprehensive overview of DNA nanostructure and DNA-inspired nanotechnology, aptamer-functionalized nanomaterials as artificial antibodies, artificial enzymes, molecular motors, and RNA structures and RNA-inspired nanotechnology. It shows how nanotechnology can be inspired by nature as well as adverse biological events in diagnostic and therapeutic development. From there, the chapters cover major important and widely used nanofabrication techniques, applications of nanotechnology for bioprocessing followed by coverage of the applications of atomic force microscopy (AFM), optical tweezers and nanofluidics as well as other nanotechnology-enabled biomolecular and cellular manipulation and detection. Focusing on major research trends, the book highlights the importance of nanobiotechnology to a range of medical applications such as stem cell technology and tissue engineering, drug development and delivery, imaging, diagnostics, and therapeutics. And with coverage of topics such as nanotoxicity, responsible nanotechnology, and educational and workforce development, it provides a unique overview and perspective of nanobiotechnology impacts from a researcher's, entrepreneur's, economist's and educator's point of view. It provides a resource for current applications and future development of nanobiotechnology.

Nanostructured materials with multiple components and complex structures are the current focus of research and are expected to develop further for material designs in many applications in electrochemical, colloidal, medical, pharmaceutical, and several other fields. This book discusses complex nanostructured systems exemplified by nanoporous silicates, spontaneously formed gels from silica-nanocolloidal solutions, and related systems, and examines them using molecular dynamics simulations. Nanoporous materials, nanocolloidal systems, and gels are useful in many applications and can be used in electric devices and storage, and for gas, ion, and drug delivery. The book gives an overview of the history, current status, and frontiers of the field. It also discusses the fundamental aspects related to the common behaviors of some of these systems and common analytical methods to treat them.

Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer markers that are under development or currently in use. It deals with a majority of commonly prevalent cancers and can help anyone working in the health-care industry to recommend or develop early diagnostics, at-risk tests, and prognostic biomarkers for various cancers. It explores the practice of determining biomarkers by their characteristics and relative methodologies, and presents the most recent data as well as a number of current and upcoming early diagnostic noninvasive molecular markers for many common cancers. It also considers the sensitivity and specificity of markers, biomarker market, test providers, and patent information. Approximately 30-35 Cancer Specific Noninvasive Molecular Diagnostic Markers in a Single Volume The book details the general and technical aspects of noninvasive cancer markers. It covers imaging, cutting-edge molecular technologies for biomarker development, and noninvasive or minimally invasive sources of molecular markers, as well as quality control and ethical issues in cancer biomarker discovery. It also provides a detailed account of brain, head and neck, and oral cancer markers, and provides information on a number of gastrointestinal cancers, lung cancer, and mesothelioma markers. Emphasizes the Importance of Volatile Markers in Early Cancer Diagnosis Presents noninvasive early molecular markers in urological cancers Describes gynecological and endocrine cancer markers Details noninvasive markers of breast, ovarian, cervical, and thyroid cancers Addresses hematological malignancies Contains information on noninvasive molecular markers in myelodysplastic syndromes, acute myeloid leukemia, Hodgkin's lymphoma, and multiple myeloma Provides comprehensive information on diagnostic and prognostic biomarkers in cutaneous melanoma This text considers molecular technologies for biomarker development, noninvasive or minimally invasive sources of molecular markers, and quality control and ethical issues in cancer biomarker discovery.

Applying Properties of Animals Skins to Inspire Architectural Envelopes Biology influences design projects in many ways; the related discipline is known as biomimetics or biomimicry. Using the animal kingdom as a source of inspiration, Ilaria Mazzoleni seeks to instill a shift in thinking about the application of biological principles to design and architecture. She focuses on the analysis of how organisms have adapted to different environments and translates the learned principles into the built environment. To illustrate the methodology, Mazzoleni draws inspiration from the diversity of animal coverings, referred to broadly as skin, and applies them to the design of building envelopes through a series of twelve case studies. Skin is a complex organ that performs a multitude of functions; namely, it serves as a link between the body and the environment. Similarly, building envelopes act as interfaces between their inhabitants and external elements. The resulting architectural designs illustrate an integrative methodology that allows architecture to follow nature. "Ilaria Mazzoleni, in collaboration with biologist Shauna Price, has developed a profound methodology for architectural and design incentives that anticipates and proposes novel ways to explore undiscovered biological inspirations for various audiences."-Yoseph Bar-Cohen

Although batch processing has existed for a long time, designing these processes and unit operations has been considered an onerous task that required computational efforts. Design of these processes is made more complex because of the time dependent nature of the process and the allowable flexibility. More often than not, every unit encounters optimal control problems. Therefore, traditional design books have not covered batch processing in detail. Filling this void, Batch Processing: Modeling and Design describes various unit operations in batch and bio-processing as well as design methods for these units. Topics include: Batch distillation operating modes and configurations Batch absorption operations based on the solubility difference Batch adsorption based on differential affinity of various soluble molecules to solid absorbents Batch chromatography for measuring a wide variety of thermodynamic, kinetic, and physico-chemical properties Batch crystallization where a phase is used to find the supersaturation at which point material crystallizes Batch drying that stresses the phase diagram of water to describe this operation Batch filtration using a porous medium or screen to separate solids from liquids Batch centrifugation where centrifugal force is used for separation Batch processes are widely used in pharmaceutical, food, and specialty chemicals where high value, low volume products are manufactured. Recent developments in bio-based manufacturing also favor batch processes because feed variations can be easily handled in batch processes. Further, the emerging area of nanomaterials manufacturing currently uses batch processes as they are low volume, high energy intensive processes. With examples, case studies, and more than 100 homework problems, this book describes the unit operations in batch and bioprocessing and gives students a thorough grounding in the numerical methods necessary to solve these design problems.

This is a review of what needs to be done to realize the potential of monoclonal antibodies. It assesses the competing technologies with advice on the best approach for a particular situation. Monoclonal antibodies have revolutionized immunology and are now promising to have a similar impact on clinical medicine. Recent developments should overcome many of the difficulties experienced in the past which has seen a great deal of talk about the therapeutic applications of monoclonal antibodies, but very little routine therapy.

Addressing medium- and long-term expectations for human health, this book reviews current scientific and technical developments in nanotechnology for biomedical, agrofood, and environmental applications. This collection of perspectives on the ethical, legal, and societal implications of bionanotechnology provides unique insight into contemporary technological developments. Readers with a technical background will benefit from the overview of the state-of-the-art research in their field, while readers with a social science background will benefit from the discussion of realistic prospects of nanotechnology. The text also includes a glossary as well as extensive end-of-chapter references.

Nanoscale techniques and devices have had an explosive influence on research in life sciences and bioengineering. Reflecting this influence, Nanopatterning and Nanoscale Devices for Biological Applications provides valuable insight into the latest developments in nanoscale technologies for the study of biological systems. Written and edited by experts in the field, this first-of-its-kind collection of topics: Covers device fabrication methods targeting the substrate on the nanoscale through surface modification Explores the generation of nanostructured biointerfaces and bioelectronics elements Examines microfluidically generated droplets as reactors enabling nanoscale sample preparation and analysis Gives an overview of key biosensors and integrated devices with nanoscale functionalities Discusses the biological applications of nanoscale devices, including a review of nanotechnology in tissue engineering Readers gain a deep understanding of the cutting-edge applications of nanotechnologies in biological engineering, and learn how to apply the relevant scientific concepts to their own research. Nanopatterning and Nanoscale Devices for Biological Applications is the definitive reference for researchers in engineering, biology, and biomedicine, and for anyone exploring the newest trends in this innovative field.

A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics research and novel technologies, supplying a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics, metagenomics, toxicogenomics, immunomics, nutrigenomics, diabetes, neurology, cardiology, and cancer to name just a few. The book begins with an overview of omics and omic technologies such as cellomics, glycomics, and lipidomics. It also discusses bioinformatics, demonstrating how it can be a tool in omics, and examines the various approaches of omics technology in toxicology research and applications in biomedical sciences. While there are a long list of omics books available, most focus narrowly on one area. Presenting a wide view of the current status of integrative omics, this resource contains complete coverage of omics in research and therapy, ranging from neuroscience to cardiology. It collates recent developments in the field into a state-of-the-art framework for this discipline.

Global energy use is approximately 140 000 TWh per year. Interestingly, biomass production amounts to approximately 270 000 TWh per year, or roughly twice as much, whereas the official figure of biomass use for energy applications is 10-13% of the global energy use. This shows that biomass is not a marginal energy resource but more than capable of meeting all our energy and food needs, provided it is used efficiently. The use of food in generating energy has been extensively debated, but there is actually no need for it given the comprehensive resources available from agriculture and forestry waste. This book discusses the biomass resources available and aspects like efficient energy use. One way of using energy efficiently is to use waste biomass or cellulosic materials in biorefineries, where production of fibers and products from fibers is combined with production of most chemicals we need in our daily life. Such products include clothes, soap, perfume, medicines etc. Conventional pulp and paper applications, bio-fuel for vehicles and even fuel for aviation as well as heat and power production are covered. The problem with biomass is not availability, but the difficulty to use the resources efficiently without harming the long-term productivity. This book covers all types of resources on a global scale, making it unique. Many researchers from all over the world have contributed to give a good coverage of all the different international perspectives. This book will provide facts and inspiration to professionals, engineers, researchers, and students as well as to those working for various authorities and organizations.

Provides theoretical insights and justification of the statistical procedures for the analysis of high-dimensional data Presents a general framework of regularization methods Covers feature screening for ultrahigh-dimensional data Describes large-scale covariance estimation

Although many significant advances have been made in biological specimen preparation during the past 20 years no new practical guide to the techniques has been published in this time. As a result of the recent resurgence of interest in light microscopy, particularly confocal techniques, this up-to-date book should benefit both the professional and amateur alike.