A "health disparity" refers to a higher burden of illness, injury, disability, or mortality experienced by one group relative to another. These disparities may be due to many factors including age, income, race, etc. This book will focus on their estimation, ranging from classical approaches including the quantification of a disparity, to more formal modelling, to modern approaches involving more flexible computational approaches. Features: * Presents an overview of methods and applications of health disparity estimation * First book to synthesize research in this field in a unified statistical framework * Covers classical approaches, and builds to more modern computational techniques * Includes many worked examples and case studies using real data * Discusses available software for estimation The book is designed primarily for researchers and graduate students in biostatistics, data science, and computer science. It will also be useful to many quantitative modelers in genetics, biology, sociology, and epidemiology.

Statistical methods are becoming more important in all biological fields of study. Biometry deals with the application of mathematical techniques to the quantitative study of varying characteristics of organisms, populations, species, etc. This book uses examples based on genuine data carefully chosen by the author for their special biological significance. The chapters cover a broad spectrum of topics and bridge the gap between introductory biological statistics and advanced approaches such as multivariate techniques and nonlinear models. A set of statistical tables most frequently used in biometry completes the book.

Applying current theory and research, this book links the development of sex differences in cognition to biological foundations, multiple social processes, and contextual factors. Areas covered include evolutionary biology, neuroscience, social roles, and cultural contextualism and the issues of the onset, causes, developmental trajectories, and patterns in children's and adolescents' thinking, problem-solving, academic performance, and social conditions that are related to behaviors in each of these areas. An edited volume with chapters by leading scholars, this book is meant for use by graduate students, researchers, and practitioners in the fields of developmental cognitive and psychology, learning and socialization, biology, and education. Cognitive domains addressed include language and verbal abilities, mathematical and quantitative abilities, spatial abilities, and social cognition.

What should the average person know about science? Because science is so central to life in the 21st century, science educators and other leaders of the scientific community believe that it is essential that everyone understand the basic concepts of the most vital and far-reaching disciplines. Biotechnology 101 does exactly that. This accessible volume provides readers - whether students new to the field or just interested members of the lay public - with the essential ideas of biotechnology using a minimum of jargon and mathematics. Concepts are introduced in a progressive order so that more complicated ideas build on simpler ones, and each is discussed in small, bite-sized segments so that they can be more easily understood. Biotechnology 101 provides an introduction to all the areas of biotechnology, covering such topics as: BLA History of the Science Behind Biotechnology BLThe Tools of Biotechnology BLBiotechnology Innovations BLPrincipal people of Biotechnology BLBiotechnology in Everyday Life BLEthical Issues of Biotechnology This short volume will enable students and lay people to understand the basics of one of the most important scientific fields of endeavor for the future.

The book is devoted to the study of limit theorems and stability of evolving biologieal systems of "particles" in random environment. Here the term "particle" is used broadly to include moleculas in the infected individuals considered in epidemie models, species in logistie growth models, age classes of population in demographics models, to name a few. The evolution of these biological systems is usually described by difference or differential equations in a given space X of the following type and dxt/dt = g(Xt, y), here, the vector x describes the state of the considered system, 9 specifies how the system's states are evolved in time (discrete or continuous), and the parameter y describes the change ofthe environment. For example, in the discrete-time logistic growth model or the continuous-time logistic growth model dNt/dt = r(y)Nt(l-Nt/K(y)), N or Nt is the population of the species at time n or t, r(y) is the per capita n birth rate, and K(y) is the carrying capacity of the environment, we naturally have X = R, X == Nn(X == Nt), g(x, y) = r(y)x(l-xl K(y)) , xE X. Note that n t for a predator-prey model and for some epidemie models, we will have that X = 2 3 R and X = R , respectively. In th case of logistic growth models, parameters r(y) and K(y) normaIly depend on some random variable y.

NEW! Now in full color! With its distinctive investigative approach to learning, this best-selling laboratory manual is now more engaging than ever, with full-color art and photos throughout. As always, the lab manual encourages students to participate in the process of science and develop creative and critical-reasoning skills. The Eighth Edition includes major revisions that reflect new molecular evidence and the current understanding of phylogenetic relationships for plants, invertebrates, protists, and fungi. The sequence of the lab topics has been reorganized to reflect the closer relationship of the fungi and animal kingdoms. A new lab topic, "Fungi," has been added, providing expanded coverage of the major fungi groups. The "Protists" lab topic has been revised and expanded with additional examples of all the major clades. Both lab topics include suggestions and exercises for open-inquiry investigations. In the new edition, population genetics is covered in one lab topic with new problems and examples that connect ecology, evolution, and genetics.

This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry professionals a comprehensive source of information on all facets of label-free biosensing and the future trends in this flourishing field. Highlights of the subjects covered include label-free biosensing with: * semiconductor field-effect devices such as nanomaterial-modified capacitive electrolyte-insulator-semiconductor structures, silicon nanowire transistors, III-nitride semiconductor devices and light-addressable potentiometric sensors * impedimetric biosensors using planar and 3D electrodes * nanocavity and solid-state nanopore devices * carbon nanotube and graphene/graphene oxide biosensors * electrochemical biosensors using molecularly imprinted polymers * biomimetic sensors based on acoustic signal transduction * enzyme logic systems and digital biosensors based on the biocomputing concept * heat-transfer as a novel transducer principle * ultrasensitive surface plasmon resonance biosensors * magnetic biosensors and magnetic imaging devices

What is Control Thought?

As explained in author Roy Messier's" The Power of Control Thought," it is learning to listen to the type of thoughts we are having and then learning how to control them. When our mind accepts an idea as true, it then becomes true for us. We have the power within to make anything happen in our lives. Control Thought is a daily guardian in every person's life.

"Bedtime Thoughts" presents a series of brief excerpts from "The Power of Control Thought" designed to be read whenever you have a few minutes. Whether you keep it on your nightstand or at your desk at work, the thoughts offered in this collection can remind you of the effect that Control Thought can have in your everyday life.

You are the orchestra and the conductor of your life; let your attitude be heard and felt all around you with Bedtime Thoughts. There is one Power, that which is within. There is one true law, and that is your own Spirit. It is the only immutable Power we know; our intuition and inspiration all come from the direction in which we turn our thoughts.

Ethnobiology and ethnoecology have become very popular in recent years. Particularly in the last 20 years, many manuals of methods have published the most classical approaches to the subject. There have been, however, many advances in research as a result of interaction with different disciplines, but also due to more recent results, new original and interesting questions. This handbook provides the current state of the art methods and techniques in ethnobiology and ethnoecology, and related fields. This new volume, besides bringing new and original aspects of what is found in the literature, fills some of the gaps in volume one by including the most systematic and extensive treatment of methods and techniques in qualitative research. Along with the various methods covered in the individual chapters, the handbook also includes an extensive bibliography that details the current literature in the field.

Combination products are therapeutic and diagnostic products that combine drugs, devices, and/ or biological products. According to the US Food and Drug Administration (FDA), “a combination product is one composed of any combination of a drug and a device; a biological product and a device; a drug and a biological product; or a drug, device and a biological product.” Examples include prefilled syringes, pen injectors, autoinjectors, inhalers, transdermal patches, drug-eluting stents, and kits containing drug administration devices co-packaged with drugs and/or biological products. This handbook provides the most up-to-date information on the development of combination products, from the technology involved to successful delivery to market. The authors present important and up-to-the-minute pre- and post-market reviews of combination product regulations, guidance, considerations and best practices. This handbook: • Brings clarity of understanding for combination products guidance and regulations • Reviews the current state-of-the-art considerations and best practices spanning the combination product lifecycle, pre-market through post-market • Reviews medical product classification and assignment issues faced by global regulatory authorities and industry The editor is a recognized international Combination Products and Medical Device expert with over 35 years of industry experience and has an outstanding team of contributors. Endorsed by AAMI – Association for the Advancement of Medical Instrumentation.

Some assumptions about biology are so deeply rooted in our thinking that they seem beyond question. These concepts - expressed in playful jargon - are our sacred bovines. With a light-hearted spirit, Douglas Allchin sets out to challenge many of these common beliefs about science and life. Allchin draws on fascinating insights from science to illustrate the ironies in many widespread beliefs. Be prepared to challenge the notion that male and female are fixed natural categories. Or that evolution implies cutthroat competition in human society. Or that we struggle against a fundamental immoral nature. Or that genes establish our identity. Or that science progresses through rare leaps of genius. Or that politics and emotions inevitably taint good science. Sacred Bovines revels in revelations about the nature of science. Reflecting on the many errors in commonly accepted, everyday ideas also fosters creative thinking. How do we challenge assumptions? How do we think outside the box? The many examples here provide inspiration and guidance, further elaborated in a retrospective epilogue. An additional "Afterword for Teachers" highlights how the essays can foster learning about the nature of science and describes some practical classroom strategies.

High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques.
The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates.
Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff.
.Shows the reader exactly how to perform modern bioanalytical sample preparation techniques, complete with detailed strategies
.Thorough literature review and summary of published information
.Detailed discussion and examples of the method development process"

This text expounds in a logical and scientific manner the idea that life did not originate on earth, but was added to it from the comets. When Fred Hoyle and Chandra Wickramasinghe first made this proposal in the 1970s, they had few takers - because the theory flew in the face of established beliefs. This text argues that in recent years, evidence to support this theory has accumulated from many different directions and grown to the point of being compelling. This work should be of value to readers interested in general science, the origin of man and the meaning of life.

At the dawn of the 21st century, biotechnology is emerging as a key enabling technology for sustainable environmental protection and stewardship. Biotechnology for the Environment: Strategy and Fundamentals captures the dynamism of environmental biotechnology as it addresses the molecular functioning of microorganisms as cleanup agents, their communal interactions in natural and polluted ecosystems, and the foundations of practical bioremediation processes. Chapters on biological pollution control in the chemical industry, biodegradation of persistent molecules (halogenated compounds, polycyclic aromatic hydrocarbons, polychlorinated biphenyls, pesticides, detergents, etc.), microbial diversity with impact on global change, bioaugmentation strategies, and sensors for ecotoxicological monitoring, will be of value to environmental scientists, engineers, and decision-makers involved in the development, evaluation, or implementation of biological treatment systems.

For information on Soil Remediation, see Focus on Biotechnology volume 3B, and for information on Waste Water and Waste Gas Handling, see Focus on Biotechnology volume 3C.

Metastasis to bone is a common event in cancer. However, due to the skeleton's unique structure, exploring how cancer cells target the skeleton and interact with the bone microenvironment is challenging. The Biology of Skeletal Metastases covers areas that are important to both clinicians and basic scientists seeking an enhanced understanding of mechanisms of skeletal metastasis, as well as descriptions of cutting edge therapies for skeletal metastases.

Both increased efforts by many investigators and advances in research methodologies have provided a wealth of information in the area of skeletal metastases. The Biology of Skeletal Metastases brings together experts to describe these many advances. This book provides background in basic bone biology and biology of metastasis for novice investigators and highlights many advances in this challenging field for the experienced investigator.

Is talent the only key to scientific success? In fact, the answer is: No'. Management and organisation do make a real, significant difference between success and failure in science. This book presents a clear survey of the critical success factors in biomedical research laboratories. Based on an international, comparative study of 71 research laboratories in medical faculties, large health research institutes and innovative pharmaceutical companies, ready-to-use guidelines are offered to those who are responsible for the management of research groups. Dr. Omta is biochemist and has played a key role in the development of the EU Biotechnology Network. He has performed the comparative study for this book in the position of Managing Director of the Institute for Research in Extramural Medicine in Amsterdam. The author has recently been appointed as Associate Professor at the Faculty of Management and Organisation at the University of Groningen, the Netherlands. This work is a unique guide for heads, professors, or managers of (biomedical) research laboratories in universities, research institutes and innovative pharmaceutical companies, who are seeking rational tools for increasing the performance and effectiveness of their research groups.