Russell/Hertz/McMillan, BIOLOGY: THE DYNAMIC SCIENCE 4e and MindTap teach Biology the way scientists practice it by emphasizing and applying science as a process. You learn not only what scientists know, but how they know it, and what they still need to learn. The authors explain complex ideas clearly and describe how biologists collect and interpret evidence to test hypotheses about the living world. Throughout, Russell and MindTap provide engaging applications, develop quantitative analysis and mathematical reasoning skills, and build conceptual understanding.

This three-volume set of Pharmaceutical Dosage Forms: Parenteral Medications is an authoritative, comprehensive reference work on the formulation and manufacture of parenteral dosage forms, effectively balancing theoretical considerations with the practical aspects of their development. As such, it is recommended for scientists and engineers in the pharmaceutical industry and academia, and will also serve as an excellent reference and training tool for regulatory scientists and quality assurance professionals.

First published in 1984 (as two volumes) and then last revised in 1993 (when it grew to three volumes), this latest revision will address the plethora of changes in the science and considerable advances in the technology associated with these products and routes of administration. The third edition of this book maintains the features that made the last edition so popular but comprises several brand new chapters, revisions to all other chapters, as well as high quality illustrations.

Volume one presents:

A historical perspective of injectable drug therapy, common routes of administration, and biopharmaceutics of NCEs and NBEs.

An in-depth discussion on the preformulation and formulation of small and large molecules, including ophthalmic dosage forms.

A presentation of parenteral primary packaging options - glass and plastic containers, as well as elastomeric closures.

A definitive chapter on container-closure integrity.

New chapters on solubility and solubilization, formulation of depot delivery systems and biophysical/biochemical characterization of proteins.

Volume two presents:

Chapters on aseptic facility design, environmental monitoring, and cleanroom operations.

A comprehensive chapter on pharmaceutical water systems.

A discussion of quality attributes of sterile dosage forms, including particulate matter, endotoxin, and sterility testing.

A detailed chapter on processing of parenteral drug products (SVPs and LVPs).

Presentations on widely used sterilization technologies steam, gas / chemical, radiation, filtration and dry heat.

An in-depth chapter on lyophilization.

Volume three presents:

An in-depth discussion of regulatory requirements, quality assurance, risk assessment and mitigation, and extractables/leachables.

Specific chapters on parenteral administrations devices, injection site pain assessment, and parenteral product specifications and stability testing.

Forward-thinking discussions on the future of parenteral product manufacturing, and siRNA delivery systems.

New chapters covering recent developments in the areas of visual inspection, quality by design (QbD), process analytical technology (PAT) and rapid microbiological methods (RMM ), and validation of drug product manufacturing process.

This book demonstrates the usefulness of tools from statistical mechanics for biology. It includes the new tendencies in topics like membranes, vesicles, microtubules, molecular motors, DNA, protein folding, phase transitions in biological systems, evolution, population dynamics, neural systems and biological oscillators, with special emphasis on the importance of statistical mechanics in their development. The book addresses researchers and graduate students.

Mammalian cells are to a large extent controlled by the environment. Dif- fusible factors (growth factors, cytokines, and hormones) released by oth- er cells in the body bind to and activate receptors localized at the cell sur- face. In the case of the fibroblast growth factor receptor, there seems to be receptors both at the plasma membrane and in the nucleus. Cellular recep- tors control growth, apoptosis, immune function, differentiation, develop- and upon dysregulation, cancer progression and metastasis. Upon li- ment, gand binding, most receptors are internalized. However, the mechanisms of endocytosis are diverse, and receptors are taken into cells from different membrane microdomains. Activation of receptors results in two important interconnected processes, namely, signal transduction and endocytosis. In- terestingly, signal transduction controls endocytosis and endocytosis con- trols signalling. In both processes sequential formation of transient protein machineries is crucial. Currently, characterization of such complex ma- chineries is advancing rapidly. It has recently become appreciated that sev- eral post-translational modifications directly control the affinity of pro- tein-protein interactions. This volume of Current Topics in Microbiology and Immunology focuses on the recent understanding of signalling from in- ternalized activated growth factor receptors. This includes information on pathways by which the rate and specificity of endocytosis and intracellular sorting are controlled. It further includes information on how specialized signalling and trafficking platforms are formed at the plasma membrane and on intracellular vesicles.

This book provides the readers with a timely guide to the application of biomimetic principles in architecture and engineering design. As a result of a combined effort by two internationally recognized authorities, the biologist Werner Nachtigall and the architect Goeran Pohl, the book describes the principles which can be used to compare nature and technology, and at the same time it presents detailed explanations and examples showing how biology can be used as a source of inspiration and "translated" in building and architectural solutions (biomimicry). Even though nature cannot be directly copied, the living world can provide architects and engineers with a wealth of analogues and inspirations for their own creative designs. But how can analysis of natural entities give rise to advanced and sustainable design? By reporting on the latest bionic design methods and using extensive artwork, the book guides readers through the field of nature-inspired architecture, offering an extraordinary resource for professional architects, engineers, designers and urban planners, as well as for university teachers, researchers and students. Natural evolution is seen throughout the book as a powerful resource that can serve architecture and design by providing innovative, optimal and sustainable solutions.

- Presents the reasons behind the decisions taken by automated algorithms - Frames eXplainable AI as a bridge between computer scientists and physicians - Emphasizes transparency in data analysis within healthcare - Covers computer vision and deep learning in tandem - Creates space to discuss human-AI relationships in future healthcare

vi on geometric probability is included, students can be expected to create a few simple programs like those shown, but for other geometries. I am indebted to Tom Hare for critical reviews of the material and an endless enthusiasm to debate and derive stereological relationships; to John Matzka at Plenum Press for patiently instructing me in the intricacies of typesetting; to Chris Russ for helping to program many of these measurement techniques; and especially to Helen Adams, both for her patience with my creative fever to write yet another book, and for pointing out that the title, which I had intended to contrast to "theoretical stereology," can also be understood as the antonym of "impractical stereology." John C. Russ Raleigh, NC July, 1986 Chapter 1: Statistics 1 Accuracy and precision 1 The mean and standard deviation 5 Distributions 7 Comparison 13 Correlation 18 Nonlinear fitting 19 Chapter 2: Image Types 23 Planar sections 23 Projected images 25 Finite sections 28 Space-filling structures and dispersed phases 29 Types of images and contrast mechanisms 31 Sampling 32 Chapter 3: Manual Methods 35 Volume fraction 35 Surface density 38 Contiguity 41 Mean intercept length 42 Line density 43 Grain size determination 55 Curvature 48 Reticles to aid counting 49 Magnification and units 51 Chapter4: Size Distributions 53 Intercept length in spheres 53 Nonspherical shapes 57 Corrections for finite section thickness 59 Lamellae 61 Measurement of profile size 62 Nonspherical particles 69 vii Contents viii Chapter 5: Computer Metlwds 73

In order to become a registered dietitian starting in January 2024, candidates will have to obtain a graduate degree from the present requirement of a bachelor's degree. Currently in the United States, there are ~ 3,000 dietitians graduating each year. While some of these candidates will choose other graduate pathways such as Food Science or an MBA, the vast majority will likely obtain a graduate degree of Masters of Science in Nutrition and Dietetics. An anticipated 2,000 dietitians per year will enroll in a graduate degree program that will in turn expect them to take in course in pediatric nutrition. Chapter design in ADIME format (see standard blurb) will prepare individuals on how to document a pediatric assessment. This book is written by practicing experts in the field and will represent presence throughout the United States. While this book is written to fulfil needs of the dietetic student population, it serves as a resource for the practicing pediatric dietitian.

Arbeitshypothesen sind revidierbar, deklarierten Wahrheiten nicht, sie verkalken zum System; Arbeitshypothesen passen sich den Menschen an, den deklarierten Wahrheiten wird der Mensch angepajJt; die ersten kann mann verwerfen, von den anderen wird man verworfen. FRIEDRICH DORRBNMATI, Nachgedanken Working hypotheses can be revised, ' declared truths cannot-they calcify into dogma. Working hypotheses adapt to people-people adapt to declared truths. One can reject the first but be rejected by the latter. The concept of electron crystallography, i.e., the quantitative use of electron diffraction intensities to solve crystal structures, is by no means new. Based on extensive pioneering efforts on organic and inorganic substances, two major works on electron diffraction structure analysis (or "electronography" as it was then known in Moscow) appeared in English translation during the 19608. These books are B. K. Vainshtein, Strukturnaya Elektronografiya (Structure Analysis by Electron Diffrac tion, translated by E. Feigl andJ. A. Spink, Pergamon Press, Oxford, 1964), and B. B."

Stephen J. Gould s greatest contribution to science is a revised version of the theory of evolution which offers today a useful framework for understanding progress in many evolutionary fields. His intuitions about the conjunction of evolution and development, the role of ecological factors in speciation, the multi-level interpretation of the units of selection, and the interplay between functional pressures and constraints all represent fruitful lines of experimental research. His opposition to the progressive representations of evolution, the gene-centered view of natural history, or the adaptationist just-so stories has also left its mark on current biology.

In May 2012, at the Istituto Veneto di Scienze, Lettere ed Arti in Venice, an international panel of scientists and philosophers discussed Stephen J. Gould s legacy, ten years after his death. This book presents a selection of those contributions, chosen for their interest and importance. A broad range of themes are covered: Gould s contribution to evolutionary theory, including the concept of punctuated equilibria and the importance of his pluralism; the Gouldian view of genome and development; Gould s legacy in anthropology; and, finally, the significance of his thought for the human sciences.

This book provides a fascinating appraisal of the cultural legacy of one of the world s greatest popular writers in the life sciences. This is the first time that scientists including some of Gould s personal friends and co-authors of papers of momentous importance such as Niles Eldredge have come together to strike a balanced view of Gould's intellectual heritage."

Suitable for both concept- and context-led approaches, this Revision Guide is Edexcel's own resource for the 2008 Edexcel GCE Biology specification. Written by experienced examiners, it features guidance from the people who write and mark exam papers and draws on real exam data from Edexcel's ResultsPlus service. 'ResultsPlus' Examiner feedback draws on examiner expertise and real past exam data to help students avoid common pitfalls and build better answers. Exam-style questions - including the multiple-choice style - offer plenty of practice ahead of the exam. Worked examples provide step-by-step guidance on how totackle exam questions. Guidance on Practical Assessment helps students to write better AS visit/case study and practical reports. Thinking tasks, quick questions and checklistsenable students to track their own progress and revise more effectively.

Suitable for both concept- and context-led approaches, this book features: 'ResultsPlus' Examiner feedback which draws on past exam data to help students avoid common pitfalls and build better answers. Exam-style questions - including the multiple-choice style - to offer plenty of practice ahead of the exam. Worked examples that provide step-by-step guidance on how to tackle exam questions. Guidance on Practical Assessment helps students to write better AS visit/case study and practical reports. Thinking tasks, quick questions and checklists enable students to track their own progress and revise more effectively.

What makes a biological entity an individual? Jack Wilson shows that past philosophers have failed to explicate the conditions an entity must satisfy to be a living individual. He explores the reason for this failure and explains why we should limit ourselves to examples involving real organisms rather than thought experiments. This book explores and resolves paradoxes that arise when one applies past notions of individuality to biological examples beyond the conventional range, and presents a new analysis of identity and persistence.

In the last fifty years our butterfly populations have declined by more than eighty per cent and butterflies are now facing the very real prospect of extinction. It is hard to remember the time when fields and meadows were full of these beautiful, delicate creatures - today we rarely catch a glimpse of the Wild Cherry Sphinx moths, Duke of Burgundy or the even once common Small Tortoiseshell butterflies. The High Brown Fritillary butterfly and the Stout Dart Moth have virtually disappeared. The eminent entomologist and award-winning author Josef H. Reichholf began studying butterflies in the late 1950s. He brings a lifetime of scientific experience and expertise to bear on one of the great environmental catastrophes of our time. He takes us on a journey into the wonderful world of butterflies - from the small nymphs that emerge from lakes in air bubbles to the trusting purple emperors drunk on toad poison - and immerses us in a world that we are in danger of losing forever. Step by step he explains the science behind this impending ecological disaster, and shows how it is linked to pesticides, over-fertilization and the intensive farming practices of the agribusiness. His book is a passionate plea for biodiversity and the protection of butterflies.

Despite 40 years of aggressive pharmaceutical and surgical interventions, coronary artery disease remains the number one killer of women and men in Western civilization. Cardiovascular disease, more than ever, demonstrates the landscape has changed so significantly, that new information must be given to the young and old health professionals seeing patients on a day to day basis. Dr. Sinatra has 40 plus years of experience in cardiovascular disease and is board-certified in internal medicine and cardiology. Dr. Mark Houston practices integrative nutritional preventive cardiology and has superb expertise in hypertension, and dyslipidemia which are major factors in the genesis of cardiovascular disease. The information in this book will give doctors-to-be, and even doctors-that-are the overlooked information they need for a balanced approach to cardiovascular treatment that includes a healing/healthy diet, nutritional supplementation, exercise and weight management. Those are crucial and powerful additions to the toolbox with which to maintain health and fix problems. That's the integrative approach that Dr. Sinatra, Dr Houston and his fellow authors, have been using with great success for decades. The Table of Contents shows a true revision - all new material - this is more of a companion volume to the original edition.

This easy-to-follow manual describes tested procedures used to prepare biological samples for scanning and transmission electron microscopy, as well as methods for cytochemistry, immunocytochemistry, and scientific photography. The work is structured to clearly define testing objectives, necessary materials, procedural steps, and expected results; a list of references and trouble shooting techniques round out the text.

"Understanding Biostatistics" looks at the fundamentals of biostatistics, using elementary statistics to explore the nature of statistical tests.

This book is intended to complement first-year statistics and biostatistics textbooks. The main focus here is on ideas, rather than on methodological details. Basic concepts are illustrated with representations from history, followed by technical discussions on what different statistical methods really mean. Graphics are used extensively throughout the book in order to introduce mathematical formulae in an accessible way.

Key features: Discusses confidence intervals and p-values in terms of confidence functions. Explains basic statistical methodology represented in terms of graphics rather than mathematical formulae, whilst highlighting the mathematical basis of biostatistics. Looks at problems of estimating parameters in statistical models and looks at the similarities between different models. Provides an extensive discussion on the position of statistics within the medical scientific process. Discusses distribution functions, including the Guassian distribution and its importance in biostatistics.

This book will be useful for biostatisticians with little mathematical background as well as those who want to understand the connections in biostatistics and mathematical issues.