In the last fifty years our butterfly populations have declined by more than eighty per cent and butterflies are now facing the very real prospect of extinction. It is hard to remember the time when fields and meadows were full of these beautiful, delicate creatures - today we rarely catch a glimpse of the Wild Cherry Sphinx moths, Duke of Burgundy or the even once common Small Tortoiseshell butterflies. The High Brown Fritillary butterfly and the Stout Dart Moth have virtually disappeared. The eminent entomologist and award-winning author Josef H. Reichholf began studying butterflies in the late 1950s. He brings a lifetime of scientific experience and expertise to bear on one of the great environmental catastrophes of our time. He takes us on a journey into the wonderful world of butterflies - from the small nymphs that emerge from lakes in air bubbles to the trusting purple emperors drunk on toad poison - and immerses us in a world that we are in danger of losing forever. Step by step he explains the science behind this impending ecological disaster, and shows how it is linked to pesticides, over-fertilization and the intensive farming practices of the agribusiness. His book is a passionate plea for biodiversity and the protection of butterflies.

Gives a convenient summary of trials in Gynecologic Oncology Supplies an invaluable revision primer for those undertaking certification Provides a uniquely up-to-date resource

A comprehensive review of the challenges that exist in patient accessibility to advanced therapy medicinal products (ATMPs), presenting clinical trials, marketing authorization, HTA, pricing, reimbursement, affordability, payment and partnership agreements of RMs and commercialisation. Specfically, we investigated how COVID-19 has impacted the RMs industry by elaborating on the disruptions it caused but also the new opportunities it brought. The ultimate goal of this work is to make strategic recommendations for manufacturers and decisions-markers on effective strategies to address the above obstacles and facilitate patient access to promising regenerative medicines. Features : Regenerative medicine (RM) is an emerging interdisciplinary field aiming to replace or regenerate human cells, tissues, or organs in order to restore normal functions. Regenerative medicine holds the promise of revolutionising treatment in the 21st century. RMs bring new hope for some previously untreatable diseases, as well as holding promise for the treatment of common chronic diseases. Rapid advancements in biotechnology and improved understanding of disease pathophysiology have attracted tremendous interests in the development of RMs. Discusses the high cost of RMs which may challenge the sustainability of healthcare insurers (public and private).

This text emphasizes the importance of artificial intelligence techniques in the field of biological computation. It also discusses fundamental principles that can be applied beyond bio-inspired computing. It comprehensively covers important topics including data integration, data mining, machine learning, genetic algorithms, evolutionary computation, evolved neural networks, nature-inspired algorithms, and protein structure alignment. The text covers the application of evolutionary computations for fractal visualization of sequence data, artificial intelligence, and automatic image interpretation in modern biological systems. The text is primarily written for graduate students and academic researchers in areas of electrical engineering, electronics engineering, computer engineering, and computational biology. This book: * Covers algorithms in the fields of artificial intelligence, and machine learning useful in biological data analysis. * Discusses comprehensively artificial intelligence and automatic image interpretation in modern biological systems. * Presents the application of evolutionary computations for fractal visualization of sequence data. * Explores the use of genetic algorithms for pair-wise and multiple sequence alignments. * Examines the roles of efficient computational techniques in biology.

Foundation Mathematics for Biosciences provides an accessible and clear introduction to mathematical skills for students of the biosciences. The book chapters cover key topic areas and their associated techniques, thereby presenting the maths in context. A student focused pedagogical approach will help students build their confidence, develop their understanding and learn how to apply mathematical techniques within their studies. Students will be able to use the book as a resource to complement their theory-based textbooks and to prepare themselves for practical classes, tutorials and research projects. Key features The book progresses in a logical manner, opening with fundamental problems and then building to more complex calculations aligned to different disciplines in the biosciences. * Worked examples with detailed solutions provide step-by-step guidance through each calculation to help students build their practical skills. * Important rules and key points are highlighted in text boxes to help students consolidate their understanding of techniques and theory. * Illustrations provide insight into what students are likely to encounter in the laboratory. * Self-assessment questions are provided throughout to enable students to manage their learning and track their progress. * Learning objectives and key terms also help students to monitor their study. Suitable for students on courses from the pure end of the spectrum to more applied courses such as biomedical sciences, microbiology, molecular biology, physiology, and forensics. Dr Ela Bryson is Senior Lecturer in Molecular Biology at the School of Life and Medical Sciences at the University of Hertfordshire Dr Jackie Willis is Associate Dean of the School of Life and Medical Sciences at the University if Hertfordshire This book can be supported by MyMathLabGlobal, an online teaching and learning platform designed to build and test your understanding. The book and the MyMathLabGlobal system provide a range of benefits including: * A tool for the diagnosis of existing strengths and weaknesses in maths * A comprehensive set of algorithmically generated questions that can be used by students to practise and develop their skills in an independent and flexible manner and by the tutor to evaluate progress Need extra support? Were you looking for the book with access to MyXLab? This product is the book alone, and does NOT come with access to MyMathLabGlobal. Buy Title with MyMathLabGlobal access card (9780273774655) if you need access to MyMathLabGlobal as well, and save money on this resource. Ask your instructor about using MyLab.

With the growing interest in and use of big data analytics in many industries and in many research fields around the globe, this new volume addresses the need for a comprehensive resource on the core concepts of big data analytics along with the tools, techniques, and methodologies. The book gives the why and the how of big data analytics in an organized and straightforward manner, using both theoretical and practical approaches. The book's authors have organized the contents in a systematic manner, starting with an introduction and overview of big data analytics and then delving into pre-processing methods, feature selection methods and algorithms, big data streams, and big data classification. Such terms and methods as swarm intelligence, data mining, the bat algorithm and genetic algorithms, big data streams, and many more are discussed. The authors explain how deep learning and machine learning along with other methods and tools are applied in big data analytics. The last section of the book presents a selection of illustrative case studies that show examples of the use of data analytics in industries such as health care, business, education, and social media. Research Practitioner's Handbook on Big Data Analytics will be a valuable addition to the libraries of practitioners in data collection in many industries along with research scholars and faculty in the domain of big data analytics. The book can also serve as a handy textbook for courses in data collection, data mining, and big data analytics.

This new volume, Advances in Food Process Engineering: Novel Processing, Preservation and Decontamination of Foods, highlights a selection of novel applications for food processing, food preservation, and food decontamination methods. The book discusses novel food processing methods, exploring the principles, benefits, and techniques used; recent developments and applications of ultrasonication; supercritical fluid extraction and supercritical fluid chromatography; extrusion technology; advanced drying and dehydration technologies; and encapsulation methods as important tools in the processing of food. Chapters on membrane technology in food processing address the basic membrane processing technologies along with their advantages and disadvantages, including membrane modules, types of membranes, and membrane technologies as well as various applications of membrane process in dairy processing, food and starch processing, beverage processing, sugar manufacturing, oil processing, and treatment of industrial food processing waste. Mathematical modeling in food processing is also considered in the volume. Chapters present the application and use of mathematical models for measuring and regulating fermentation procedures as well as provide an understanding of how the hydration kinetics of grains can help in optimization and scaling of processes on a large industrial scale. Topics on decontamination methods for foods are included, such as an overview of concepts, basic principles, potential applications, and prospects and limitations of cold plasma technology and irradiation in the food processing sector has been summarized. This volume provides excellent reference material for researchers, scientists, students, growers, traders, processors, industries, and others on novel food processing and preservation techniques.

Nowadays, raw biological data can be easily stored as databases in computers but extracting the required information is the real challenge for researchers. For this reason, bioinformatics tools perform a vital role in extracting and analyzing information from databases. Bioinformatics Tools and Big Data Analytics for Patient describes the applications of bioinformatics, data management, and computational techniques in clinical studies and drug discovery for patient care. The book gives details about the recent developments in the fields of artificial intelligence, cloud computing, and data analytics. It highlights the advances in computational techniques used to perform intelligent medical tasks. Features: Presents recent developments in the fields of artificial intelligence, cloud computing, and data analytics for improved patient care. Describes the applications of bioinformatics, data management, and computational techniques in clinical studies and drug discovery. Summarizes several strategies, analyses, and optimization methods for patient healthcare. Focuses on drug discovery and development by cloud computing and data-driven research The targeted audience comprises academics, research scholars, healthcare professionals, hospital managers, pharmaceutical chemists, the biomedical industry, software engineers, and IT professionals.

Environmental Science:A Global Concern is a comprehensive presentation of environmental sciencefor non-science majors which emphasizes critical thinking, environmentalresponsibility, and global awareness. This book is intended for use in a one ortwo-semester course in environmental science, human ecology, or environmentalstudies at the college or advanced placement high school level.

The book is an introduction to nanomedicine informed by a philosophical reflection about the domain and recent developments. It is an overview of the field, sketching out the main areas of current investment and research. The authors present some case-studies illustrating the different areas of research (nanopharmacy, theranostics and patient monitoring) as well as reflecting on the risks that accompany it, such as unanticipated impacts on human health and environmental toxicity. This introduction to a fast-growing field in modern medical research is of great interest to researchers working in many disciplines as well as the general public. In addition to an overview of the work currently ongoing, the authors critically assess these projects from an ethical and philosophical perspective. Key Features Provides an overview of nanomedicine Employs a reflective and coherent critical evaluation of the benefits and risks of nanomedicine Written in an accessible manner intended for a wide audience Related Titles Hehenberger, M. Nanomedicine: Science, Business, and impact (ISBN 978-9-8146-1376-7). Beg, S., et al. Nanomedicine for the treatment of Disease: From Concept to Application (ISBN 978-1-7746-3443-1) Brenner, S. The Clinical Nanomedicine Handbook (ISBN 978-1-1380-7578-8)

The book is an introduction to nanomedicine informed by a philosophical reflection about the domain and recent developments. It is an overview of the field, sketching out the main areas of current investment and research. The authors present some case-studies illustrating the different areas of research (nanopharmacy, theranostics and patient monitoring) as well as reflecting on the risks that accompany it, such as unanticipated impacts on human health and environmental toxicity. This introduction to a fast-growing field in modern medical research is of great interest to researchers working in many disciplines as well as the general public. In addition to an overview of the work currently ongoing, the authors critically assess these projects from an ethical and philosophical perspective. Key Features Provides an overview of nanomedicine Employs a reflective and coherent critical evaluation of the benefits and risks of nanomedicine Written in an accessible manner intended for a wide audience Related Titles Hehenberger, M. Nanomedicine: Science, Business, and impact (ISBN 978-9-8146-1376-7). Beg, S., et al. Nanomedicine for the treatment of Disease: From Concept to Application (ISBN 978-1-7746-3443-1) Brenner, S. The Clinical Nanomedicine Handbook (ISBN 978-1-1380-7578-8)

Combination products are therapeutic and diagnostic products that combine drugs, devices, and/ or biological products. According to the US Food and Drug Administration (FDA), “a combination product is one composed of any combination of a drug and a device; a biological product and a device; a drug and a biological product; or a drug, device and a biological product.” Examples include prefilled syringes, pen injectors, autoinjectors, inhalers, transdermal patches, drug-eluting stents, and kits containing drug administration devices co-packaged with drugs and/or biological products. This handbook provides the most up-to-date information on the development of combination products, from the technology involved to successful delivery to market. The authors present important and up-to-the-minute pre- and post-market reviews of combination product regulations, guidance, considerations and best practices. This handbook: • Brings clarity of understanding for combination products guidance and regulations • Reviews the current state-of-the-art considerations and best practices spanning the combination product lifecycle, pre-market through post-market • Reviews medical product classification and assignment issues faced by global regulatory authorities and industry The editor is a recognized international Combination Products and Medical Device expert with over 35 years of industry experience and has an outstanding team of contributors. Endorsed by AAMI – Association for the Advancement of Medical Instrumentation.

Originally developed for the author's course at Union College, this text is directed at life science students who need to understand the connections of fundamental physics to modern biology and medicine. To aid learning, each chapter contains open-ended questions, multiple-choice questions and quantitative problems.

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics. Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results. The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations. The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language. The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments. Features Offers first-hand, in-depth guidance on Mendelian randomization from leaders in the field Makes the diverse aspects of Mendelian randomization understandable to newcomers Illustrates technical details using data from applied analyses Discusses possible future directions for research involving Mendelian randomization Software code is provided in the relevant chapters and is also available at the supplementary website This book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data. New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues. Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added. The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development

Topical and transdermal drug delivery systems (TDDs) have several advantages over traditional drug delivery methods, as they can be less invasive, more sanitary, more cost-effective, and may result in better patient compliance. TDDs play a significant role in therapeutics with a variety of preparations and approaches designed by expert formulation scientists. This volume integrates a wide variety of case studies, research, and theories to reveal their diversity and capture the novel approaches of transdermal and topical drug delivery employed by developers and content experts in the field. It provides an abundance of important information and state-of-the-art research on topical and transdermal drug delivery systems and addresses the basics of drug delivery systems, strategies to enhance permeation across membranes, and formulation and evaluation of diverse dosage forms. The volume presents an evaluation of the pros and cons of conventional drug delivery systems against TDDs and discusses the nuances of micro- and nano-systems in TDDs. The extraordinary packages of nano systems (vesicular systems, polymeric nanoparticles, nanoemulsion and dendrimers) are broadly discussed, and their applications are reviewed through a transdermal route. The book looks at TDDs and the main nanoparticles used in skin diseases and lesions of the aging, such as psoriasis, vitiligo, cancer, lesions of the aging and others. Chapters also discuss polymeric micelles in topical and transdermal delivery; microneedles; emulsion, nanoemulsion and microemulsion; TDDs in pulmonary drug delivery systems; nanoencapsulated nasal drug delivery systems; skin sensitivity and irritation testing for transposing transdermal drug delivery systems; and regulatory aspects of drug development for dermal products. Topical and Transdermal Drug Delivery Systems: Applications and Prospects will be a valuable resource for pharmaceutical scientists and researchers, industry professionals, and academicians and students of the pharmaceutical and biomedical sciences.

The newest edition of Knisely's Student Handbook for Writing in Biology is the helping hand your students are looking for, offering the support they need to write within the conventions of biology. Topics range from reading technical literature and writing scientific papers, to preparing lab reports and giving oral presentations of scientific findings. Students get practical advice from MS Office appendices, tutorial videos, and various checklists. Examples and resources throughout the text show not just what to do, but how to do it. The newest edition mirrors the ways students use online resources and social media platforms for research, making sure the information is both credible and relevant. A new statistics chapter covers the application of descriptive statistics to actual datasets and selected tests of significance. The newest edition of Knisely's Student Handbook for Writing in Biology is the helping hand your students are looking for, offering the support they need to write within the conventions of biology. Topics range from reading technical literature and writing scientific papers, to preparing lab reports and giving oral presentations of scientific findings. Students get practical advice from MS Office appendices, tutorial videos, and various checklists. Examples and resources throughout the text show not just what to do, but how to do it. The newest edition mirrors the ways students use online resources and social media platforms for research, making sure the information is both credible and relevant. A new statistics chapter covers the application of descriptive statistics to actual datasets and selected tests of significance. The newest edition of Knisely's Student Handbook for Writing in Biology is the helping hand your students are looking for, offering the support they need to write within the conventions of biology. Topics range from reading technical literature and writing scientific papers, to preparing lab reports and giving oral presentations of scientific findings. Students get practical advice from MS Office appendices, tutorial videos, and various checklists. Examples and resources throughout the text show not just what to do, but how to do it. The newest edition mirrors the ways students use online resources and social media platforms for research, making sure the information is both credible and relevant. A new statistics chapter covers the application of descriptive statistics to actual datasets and selected tests of significance.

-Describes the basic ideas underlying each concept and model. -Includes R, SAS, SPSS and Stata programming codes for all the examples -Features significantly expanded Chapters 4, 5, and 8 (Chapters 4-6, and 9 in the second edition. -Expands discussion for subtle issues in longitudinal and clustered data analysis such as time varying covariates and comparison of generalized linear mixed-effect models with GEE.

Women are contributing to disciplines once the sole domain of men. Field biology has been no different. The history of women field biologists, embedded in a history largely made and recorded by men, has never been written. Compilations of biographies have been assembled, but the narrative-their story-has never been told. In part, this is because many expressed their passion for nature as writers, artists, collectors, and educators during eras when women were excluded from the male-centric world of natural history and science. The history of women field biologists is intertwined with men's changing views of female intellect and with increasing educational opportunities available to women. Given the preponderance of today's professional female ecologists, animal behaviorists, systematists, conservation biologists, wildlife biologists, restoration ecologists, and natural historians, it is time to tell this story-the challenges and hardships they faced and still face, and the prominent role they have played and increasingly play in understanding our natural world. For a broader perspective, we profile selected European women field biologists, but our primary focus is the journey of women field biologists in North America. Each woman highlighted here followed a unique path. For some, personal wealth facilitated their work; some worked alongside their husbands. Many served as invisible assistants to men, receiving little or no recognition. Others were mavericks who carried out pioneering studies and whose published works are still read and valued today. All served as inspiration and proved to the women who would follow that women are as capable as men at studying nature in nature. Their legacy lives on today. The 75 female field biologists interviewed for this book are further testament that women have the intellect, stamina, and passion for fieldwork.

Estimation of the Time Since Death remains the foremost authoritative book on scientifically calculating the estimated time of death postmortem. Building on the success of previous editions which covered both the early and later postmortem periods this edition includes a new chapter on DNA/RNA degradation and further new content on drug testing in hair, thus widening the scope of the material. Chapters have been improved, updated and expanded, and include new and additional images to enhance the text. A unique work of synthesis combining rigorous science with practical guidance, this update reinforces the book's reputation as an invaluable resource - and also the standard - for the estimation of the time since death.

This volume focuses on the family Euphorbiaceae. They are well defined tribe which includes ten other small genera of tropical and sub-tropical regions. Euphorbia are annual, biennial or perennial herbs, shrubs or trees, sometimes succulent and unarmed or spiny, with a milky usually caustic latex.

Investigating Sexual Assault Cases, Second Edition serves as an essential textbook for courses in investigating rape and sexual assault. As with the first edition, this second edition includes the latest research and techniques in coverage of victimology, offender typology, investigative techniques, interviewing, and legal implications. This new, second edition includes chapters on child victims and molestation, sexual homicides as potentially staged events, grooming, interviewing techniques, and same-sex, elder, and special populations as victims of sexual assault. The book fills a current void in the body of literature on the topics of rape and sex crime investigation. Many previous writings, while informative, do not address all the investigative processes necessary for an investigation to be thorough and complete. By providing a fresh approach to the topic, the author aims to augment those writings and, ultimately, improving the reader' awareness by being much more attuned to the needs of-and taking investigative cures from-the victim. Key Features: Outlines the complete investigative process for sexual assault cases, from evidence collection and interviews to court and legal proceedings Addresses victims and victimology, offender typology, the importance of the investigative interviewing process, and working with attorneys Includes new chapters on grooming, sexual homicides, SAFE examinations, and child-specific interviewing techniques Added coverage looks at same-sex crimes, crimes against men, elder victims, and assault of vulnerable populations In addition to being used in coursework in Forensic Science and Criminal justice programs, Investigating Sexual Assault Cases, Second Edition will serve as an essential reference for police detectives, criminal and death investigators, legal professionals, sexual assault nurses, and those who provide health, and mental health, services to populations experiencing sexual assault.

Defines the term "cognitive evidence" and describes the process for retrieving reliable evidence in a way that maintains integrity throughout the interviewing process Outlines guidance on developing a mindful—rather than prescriptive or rote—approaches to conducting eyewitness interviews Provides guidance for analyzing interviews and improving the interview process Presents specific procedures to interview an eyewitness for a criminal event for both victims and witnesses

Explores text mining and IoT applications for monitoring and controlling smart industrial systems Describes the key principles and techniques for Big-data analytics, security, and optimization for industrial applications. Provides context-aware insights, human-centric industry, smart computing for next-generation industry