Head injuries are commonplace. Though most patients survive, the consequences, both physical and social, can be devastating. The methods of initial assessment and management can have a crucial effect on determining the outcome of the injury, and long-term effects. However, only a minority of head-injured patients are cared for by Neurosurgeons. The majority are seen by non-specialists, often junior doctors and nurses, and treated in district hospitals where specialist neurosurgical assistance is unavailable. As a guide for doctors and nurses working in the A & E department, or the Orthopaedic or General Surgical Ward, the emphasis of this book is on the early management of the head- injured patient. New to the second edition are chapters on managing the 'disturbed' head injured patient, a chapter of special value to nurses (who often have to deal with this difficult task). A new chapter on anaesthesia and head injuries has also been added, with other chapters significantly revised to reflect the crucial role played by anaesthetists in head injury management. Providing practical advice on the early treatment of minor head injuries, and the management of major head injuries, the book provides advice that will be essential in ensuring effective treatment of these patients. From reviews of first edition: '... an excellent account of the management of head injuries... this one certainly fulfils its stated aim and is to be recommended.' JOURNAL OF NEUROLOGY, NEUROSCIENCE, AND PSYCHIATRY '... concise and well-referenced... a worthwhile addition to an A& E department's bookshelves.' NURSING TIMES 'The text is easy to read, and is of particular use to non-specialist staff... Useful as an introduction for junior neurosurgeons in training.' ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND

This practical guide provides a focus on the implementation of healthcare simulation operations, as well as the type of professional staff required for developing effective programs in this field. Though there is no single avenue in which a person pursues the career of a healthcare simulation technology specialist (HSTS), this book outlines the extensive knowledge and variety of skills one must cultivate to be effective in this role. This book begins with an introduction to healthcare simulation, including personnel, curriculum, and physical space. Subsequent chapters address eight knowledge/skill domains core to the essential aspects of an HSTS. To conclude, best practices and innovations are provided, and the benefits of developing a collaborative relationship with industry stakeholders are discussed. Expertly written text throughout the book is supplemented with dozens of high-quality color illustrations, photographs, and tables. Written and edited by leaders in the field, Comprehensive Healthcare Simulation: Operations, Technology, and Innovative Practice is optimized for a variety of learners, including healthcare educators, simulation directors, as well as those looking to pursue a career in simulation operations as healthcare simulation technology specialists.

Anaesthetic trainees often have enormous trouble understanding the quantitative aspects of the basic sciences underlying clinical anaesthetic practice. The subjects of pharmokinetics and statistics are often unpopular with trainees, and studied with little enthusiasm. In spite of their reluctance, this is an area that they are required to study and understand as a core part of their training for postgraduate exams. Mathematics and statistics for anaesthetists presents simple mathematical ideas, and explains how these can be used to model and understand problems which arise in clinical anaesthesia. The common features of the underlying mathematics are emphasised through a pictorial/graphical approach, in preference to vast amounts of algebra. The book presents statistics in an informal and less intimidating style that most standard statistical texts, incorporating illustrations and cartoons throughout. The book will be valuable to anaesthetists, in guiding them through what can be an intimidating part of their training.

This book is a comprehensive guide to Targeted Drug Delivery (TDD), also known as Intrathecal Drug Delivery (IDD), and offers an overview to this unique form of treatment. The medication is delivered by intrathecal pumps and is less common than some other techniques for interventional pain management, but is essential in conditions such as refractory pain, cancer pain, multifocal pain, severe spasticity, and in patients who are not candidates for surgical correction of their underlying condition. This book is the first source to describe both the optimal surgical implantation and patient management aspect of this therapy, and thus will be a valuable single reference guide for interventional radiologists, anesthesiologists, physiatrists, oncologists, neurologists, spine surgeons, palliative care physicians, and primary care physicians.

This book provides readers with an anaesthesia-focused alternative to general physiology textbooks. The new edition has been reorganised with the trainee anaesthesist in mind, into shorter bite-sized chapters ideal for exam revision. The content includes the physiology of all major organ systems, with specific emphasis on the nervous, respiratory, and cardiovascular systems as well as special sections on pain, aging, specific environments and obesity. Alongside the learning objectives, reflection points and a handy summary of physiological equations and tables, there is greater emphasis on clinical application in this fourth edition, with applied physiology included in almost every section.

Table of Contents

Preface to the first edition

Preface to the second edition

Preface to the third edition

Preface to fourth edition

Acknowledgements

Authors

Contributors

Section One: Basic Cell Physiology

1. Cell Components and Function

2. Physiology of Excitable Cells

3. Neurotransmitters and Receptors, Ion Channels, G Proteins and Second Messengers

Section Two: Physiology of the Nervous System

4. Neuronal Function

5. Blood–Brain Barrier and Cerebrospinal Fluid (CSF)

6. Cerebral Circulation

7. Spinal Cord: Anatomical and Physiological Features

8. Sensory System

9. Motor Function and Control: Descending Tracts

10. Autonomic Nervous System

11. Consciousness, EEG, Sleep and Emotions

Section Three: Muscle Physiology

12. Striated Muscles: Skeletal and Cardiac Muscles

13. Muscle Spindles, Golgi Tendon Organs and Spinal Reflexes

14. Smooth Muscle

Section Four: Respiratory Physiology

15. Functions of the Respiratory System

16. Mechanical Properties of the Lungs

17. Gas Exchange in the Lungs

18. Carriage of Oxygen in Blood

19. Carbon Dioxide Carriage in Blood

20. Pulmonary Circulation

21. Control of Ventilation

22. Applied Respiratory Physiology

Section Five: Cardiovascular Physiology

23. Functions of the Cardiovascular System

24. Electrical Properties of the Heart

25. Mechanical Events of the Cardiac Cycle

26. Pressure–Volume Loop of the Left Ventricle

27. Physical Factors Governing Blood Flow Through Vessels

28. The Systemic Circulation

29. Microcirculation

30. Venous Return and Vascular Function

31. Regulation of Arterial Blood Pressure

32. Integrated Cardiovascular Responses

Section Six: Gastrointestinal Physiology

33. Saliva, Swallowing, and Lower Oesophageal Sphincter

34. Stomach: Gastric Secretions, Motility, Digestion and Vomiting

35. The Small Intestine: Secretions, Digestion and Motility

36. The Large Intestine

Section Seven: Liver Physiology

37. Functions of the Liver

38. Liver Blood Flow

39. Liver Function Tests and Physiological Features of Liver Failure

Section Eight: Renal Physiology

40. Functions of the Kidneys and Functional Anatomy

41. Renal Blood Flow

42. Glomerular Filtration

43. Tubular Function

44. The Loop of Henle and Production of Concentrated Urine: Counter-Current Mechanisms of the Kidney

45. Overview of Renal Control of Acid–Base Balance

46. Applied Physiology: Renal Failure

Section Nine: Acid–Base Physiology

47. Basic Concepts of Acid–Base Physiology

48. Compensatory Mechanisms in Acid–Base Disorders

49. Clinical Aspects of Acid–Base Control

50. Anion Gap and Stewart’s Strong Ion Difference

Section Ten: Physiology of Blood

51. Cellular Components of Blood

52. Plasma: The Non-Cellular Components of Blood

53. Haemostasis

54. Blood Transfusion

Section Eleven: Physiology of the Immune System

55. Immune System and Innate Immunity

56. Acquired Immunity

57. Cytokines

58. Hypersensitivity

Section Twelve: Endocrine Physiology

59. General Aspects of Endocrine Physiology

60. Pituitary Gland

61. Hormones of the Pancreas

62. Thyroid Hormones and Calcium Metabolism

63. Hormones of the Adrenal Gland

64. Erythropoietin, Atrial Natriuretic Peptide and Sex Hormones

Section Thirteen: Metabolism, Nutrition, Exercise and Temperature Regulation

65. Metabolism

66. Nutrition

67. Exercise Physiology

68. Temperature Regulation

Section Fourteen: Physiology of Pain

69. Peripheral Mechanisms of Pain

70. Central Modulation of Pain

71. Pain Sensitization

Section Fifteen: Physiology of Pregnancy, Placenta, Neonate, Ageing and Obesity

72. Physiology of Pregnancy

73. Physiology of the Placenta

74. Physiology of the Neonate

75. Physiology of Ageing

76. Physiology of Obesity

Section Sixteen: Special Environments

77. Physiology Related to Special Environments

Further reading

Index

　

This manual describes in simple language the clinical and technical skills of an anaesthetic assistant. The key learning points are highlighted, and a comprehensive up-to-date reading list is included to guide the trainee to areas of further reading.

Cardiac Anaesthesia: A Practical Approach is the first concise reference text to cover all aspects of cardiac anaesthesia. Aimed at trainee anaesthetists and cardiac anaesthetic nurses, the book presents clear and concise guidelines enabling the medical practitioner with little or no cardiac experience to develop and practise the required skills. For convenience the book has been divided into three main sections: Anatomy, physiology, and pharmacology Anaesthesia for adults Anaesthesia for children For both adults and children, the book explains how to prepare the patient for cardiac surgery, presents instructions on anaesthesia for different types of cardiac surgery, and provides information on postoperative care. Cardiac Anaesthesia: a practical handbook will be an essential guide for anaesthetists in training, and nurses involved in the care of cardiac patients.

This concise reference provides a core curriculum for those who have to look after critically ill children. Early recognition of those children who need intensive care, prompt resuscitation, and safe transportation to specialized units are the keys to success for the sickest children. Management of the common disorders is covered in a practical manner, as are the legal and ethical considerations.

Regional anaesthesia is currently undergoing a renaissance in paediatric anaesthetic practice, particularly in day case surgery, for post-operative pain relief and in ex-premature babies. However, most practical textbooks of local anaesthetic technique are not written with small children, and particularly newborn infants, in mind.

This practical manual has been designed to aid both those aiming to refresh their knowledge of the techniques of regional anaesthesia in babies and children, and those learning these methods for the first time. Whilst it is not intended as a substitute for direct trainig by experts, its clear and concise text and simple diagrams make it an ideal companion to 'hands on' training in the operating theatre. Both authors have extensive experience of teaching anaestheitc trainees.

The two introductory chapters of this book describe the relevant pharmacological and biological differences between infants, children and adults, and the general practical aspects of regional anaesthesia. The book is then divided into sections describing the nerve blocks of the major anatomical regions of the body. The descriptions of the different blocks can be read independently and include the relevant anatomy, indications, specific contraindictions, equipment, drugs and dosages, Each description concludes with a step-by-step guide to the block illustrated with photographs and simple diagrams.

This book highlights remarkable new endoscopic, laparoscopic, and thoracoscopic approaches to the removal of surgical lesions for different pathologic conditions under general endotracheal anesthesia in infants and children. It details how newer techniques in airway management, monitoring, regional nerve blocks for these innovative minimally invasive approaches have resulted in a decrease in intraoperative and postoperative morbidity and early recovery process after pediatric anesthesia. This unique book contains features that provide the audience with several clinical scenarios where exceptional surgical outcomes are achieved with optimum pre-op preparation via collaborative team efforts. To date there is no other textbook emphasizing the anesthetic and surgical management during the most innovative advances in endoscopic surgery in children. Per oral endoscopic myotomy (POEM) for the definitive treatment of achalasia in children is probably the most advanced endoscopic surgery done successfully in children. POEM is the best example of endoscopic surgery performed via natural orifices known as the Natural orifice transluminal endoscopic surgery (NOTES). Another new laparoscopic surgical intervention -Median Arcuate Ligament surgical release for Median Arcuate Ligament Syndrome (MALS) for patients with Postural Orthostatic Tachycardia Syndrome (POTS) is described with established perioperative protocols emphasizing the need for early admission, intravenous hydration, and premedication. Novel approaches in the anesthetic management in children with short bowel syndrome for bowel lengthening techniques like the serial transverse enteroplasty (STEP) and in teenagers for laparoscopic bariatric surgery with adjustable gastric banding (AGB) and vertical sleeve gastrectomy (VSG) for morbid obesity are new areas that would enlighten the readers. Anesthetic Management in Pediatric General Surgery is an invaluable resource for pediatric anesthesiologists, surgeons, and their trainees specializing in the care of pediatric patients.

Fundamentals of Anaesthesia is the gold standard text for the Primary FRCA, encapsulating the basic principles of modern anaesthesia in one easily accessible volume. Written and edited by experts with extensive FRCA examination experience, this text deliberately blends the expertise of invited authors in an unrivalled consistency of style more akin to that of a single author text. All of the subject matter required to pass the exam is condensed into an easy-to-read format. This fully updated fourth edition includes new guidelines, an improved chapter structure, and a new section on clinical ultrasound. The generous use of summary boxes, bullet points, tables and diagrams creates a text that is clear, concise and easy to navigate. Each section covers one of the four components of the SOE. This is a unique revision aid for the Primary FRCA and an essential companion for all exam candidates.

This comprehensive book is written to inform and improve outcomes of patients in need of blood management during surgical procedures. Information is presented in an accessible format, allowing for immediate use in clinical practice. Beginning with an overview of the history of blood transfusions, early chapters present the foundational information needed to comprehend information in later chapters. Nuanced procedures, drugs, and techniques are covered, including new biologicals to assist clotting and blood substitutes. Further discussions focus on potential complications seen in blood transfusions, such as diseases of the coagulation system, pathogen transmissions, and acute lung injuries. Chapters also examine the complexities of treating specific demographics, of which include the geriatric patient and patients suffering from substance abuse. Essentials of Blood Product Management in Anesthesia Practice is an invaluable guide for anesthesiologists, surgeons, trauma physicians, and solid organ transplant providers.

This book comprehensively addresses the use of pulmonary function measurement for the evaluation, screening and timing of noninvasive mechanical ventilation (NIMV) from hospital to home care. To do so, it describes three clinical stages of NIMV support: before NIV, to detect early markers and determine whether NIV is appropriate; during NIV, to evaluate NIV response; and in long-term NIV support. Additionally, it assesses a range of complementary health care organizations (pulmonary function labs, pneumology wards, semi-intensive care units and home mechanical ventilation programs), techniques (chest physiotherapy/airway secretions, etc.) and applications. In closing, the book offers practical recommendations on how noninvasive ventilation and lung function measurement can improve outcomes and quality of life, making it a valuable resource for all specialists, e.g. intensivists and pneumologists, as well as anesthesiologists and therapists.

Pain is something that everyone feels but has always been difficult to understand and investigate due to its subjective nature. Practical Pain Management is written for all those involved in the care of people suffering from pain. The authors explain why pain is so often disregarded and poorly managed by clinicians. With an emphasis on the practical management of both chronic and acute pain, the book explores the mechanisms involved in pain percepetion, the use of analgesic drugs, local anesthetics, nerve blocks and stimulation techniques. The rehabilitation and care of patients whose pain cannot be adequately relieved is also considered and some ways in which specialist pain services can help with chronic pain syndromes are described. This comprehensive guide will help all those caring for patients in pain to have a better understanding of pain and to work more effectively towards its management.

This book discusses all thoracic diseases of surgical interest, from thorax malformations to airways disorders. It is divided into six main sections; the first two analyze general aspects, while the following three focus on malformations of the thorax, airways, esophagus and diaphragm. The final section describes the main pediatric tumors involving the chest and internal thoracic organs. Each chapter starts with a classification of the main pathologies related to the anatomical region considered. For each pathology, the various aspects of the diagnostic-therapeutic procedure are described in details - from the clinical presentation and diagnosis to the pre-operative preparation, the surgical aspects, and the post-operative course. Possible future developments are also evaluated. The volume will be a useful tool for specialists in pediatric and thoracic surgery, but will also represent an educational resource for medical and nursing students.

The 2nd edition of this book describes the recent techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill, defined as those who have acute failure of at least one organ, due to either a pathological condition or a medical intervention, and require intensive care treatment. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as noninvasive mechanical ventilation, protective ventilation, prone positioning, intravenous salbutamol in ARDS, high-frequency oscillatory ventilation, mild hypothermia after cardiac arrest, daily interruption of sedatives, tranexamic acid, diaspirin cross-linked hemoglobin, albumin, growth hormone, glutamine supplementation, tight glucose control, supranormal oxygen delivery, and hydroxyethyl starch in sepsis. The topics selection was performed with the help of hundreds of specialists from dozens of countries; they expressed via web if they agreed or not with these topics and if they used them in their daily clinical practice. The clear text is supported by "how to do" sections and "key point" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in Critically Ill Patients is of interest for a wide variety of specialists, including intensivists, emergency doctors, and anesthesiologists.

"Extracorporeal Membrane Oxygenation : An Interdisciplinary Problem-Based Learning Approach" provides an overview of the latest techniques, management strategies and technology surrounding the clinical use of ECMO. This interdisciplinary book reviews the most common scenarios of ECMO in 62 chapters exploring the conditions and problems arising in ECMO practice. Each chapter begins with a stem case, followed by open questions to encourage critical thinking and enable the reader to follow the management strategies of the authors, who are world leaders in the field. Followed by an evidence-based discussion, each chapter concludes with multiple-choice questions for self-assessment. This book is current in its knowledge of organ systems and management and keeps pace with new ECMO technology and surgical techniques coupled with current guidelines for management. Starting with the history of ECMO to technical aspects, circuit biocompatibility and interaction with blood, drugs and flow physics, the volume continues into pediatric and adult sections, focussing on both respiratory and cardiovascular support, followed by a section on trauma. The volume then concludes with a section on neurologic complications and ethics, as well as rehabilitation and ambulation of ECMO patients. In addition, to reflect the current global health situation, this book also includes a chapter on ECMO management in patients suffering with COVID-19, to cover the most urgent and pressing questions around ECMO during the ongoing pandemic. This is the first ECMO book on the market to utilise a problem-based learning approach and as such is an important unprecedented project on ECMO education.

This book provides a practically applicable guide on how to develop essential microsurgery skills and successfully perform a range of procedures. Emphasis is placed within each chapter on equipping the reader with the necessary information to enable them to develop a strong foundational knowledge of every technique covered with clear step-by-step guides on how to perform a range of methodologies. Helpful tips are provided on how to avoid common pitfalls and enhance skill acquisition. Accompanying video material also reinforces the key points detailed. Topics covered include how to develop skills utilizing the porcine model of flap harvesting along with the use of animal models for techniques such as vascular anastomoses, anesthesia, and exposure of relevant recipient vessels. Microsurgery Manual for Medical Students and Residents is a detailed resource on how to acquire core microsurgery skills, making it an ideal resource for medical students and trainees seeking a resource on how to further develop their skills.

This specially-designed, practical, easy-to-use handbook presents reference data for health professionals, especially clinical geneticists, evaluating children and adults with abnormal features or syndromes. Using a mixture of graphs, tables, and charts, it presents information clinicians require to define 'normal' patterns of growth for various parts of the body, and provides the standards against which to compare possible congenital abnormalities. Numerous illustrations help to explain exactly how standardized measurements should be taken to ensure accurate and comparable documentation of growth patterns.

This comprehensive book is written to inform and improve outcomes of patients in need of blood management during surgical procedures. Information is presented in an accessible format, allowing for immediate use in clinical practice. Beginning with an overview of the history of blood transfusions, early chapters present the foundational information needed to comprehend information in later chapters. Nuanced procedures, drugs, and techniques are covered, including new biologicals to assist clotting and blood substitutes. Further discussions focus on potential complications seen in blood transfusions, such as diseases of the coagulation system, pathogen transmissions, and acute lung injuries. Chapters also examine the complexities of treating specific demographics, of which include the geriatric patient and patients suffering from substance abuse. Essentials of Blood Product Management in Anesthesia Practice is an invaluable guide for anesthesiologists, surgeons, trauma physicians, and solid organ transplant providers.

This book gathers the proceedings of the 17th International Conference on Intracranial Pressure and Neuromonitoring, held in Leuven, Belgium in September 2019. It provides an overview of the current understanding, underlying research and future perspectives concerning pathophysiology, biophysics, monitoring and management in traumatic and non-traumatic acute brain injury, hydrocephalus and spinal cord injury, including cerebrovascular autoregulation impairment in neurological as well as non-neurological diseases. The peer-reviewed contributions were prepared by specialists in neurosurgery, neurointensive care and neuroanesthesiology, as well as prominent experts from the fields of physiology, clinical and biomedical engineering, mathematics and informatics. The book continues the time-honored tradition of publishing key presentations from the ICP Conferences in order to facilitate their dissemination within the clinical and research community.

Although most clinicians are aware of the problem of antimicrobial resistance, most also underestimate its significance in their own hospital. The incorrect and inappropriate use of antibiotics and other antimicrobials, as well as poor prevention and poor control of infections, are contributing to the development of such resistance. Appropriate use of antibiotics and compliance with infection prevention and control measures should be integral aspects of good clinical practice and standards of care. However, these activities are often inadequate among clinicians, and there is a considerable gap between the best evidence and actual clinical practice. In hospitals, cultural determinants influence clinical practice, and improving behaviour in terms of infection prevention and antibiotics-prescribing practice remains a challenge. Despite evidence supporting the effectiveness of best practices, many clinicians fail to implement them, and evidence-based processes and practices that are known to optimize both the prevention and the treatment of infections tend to be underused. Addressing precisely this problem, this volume offers an essential toolkit for all surgeons and intensivists interested in improving their clinical practices.

This book is a comprehensive guide to ophthalmic anaesthesia detailing different types of anaesthesia, techniques, subsequent effects and possible complications. Divided into six sections the book begins with basic clinical knowledge including anatomy and physiology and the effects of ocular medications. The following sections examine the techniques and uses of regional anaesthesia, concluding with a chapter on emergencies in ocular surgery. The second half of the book covers general anaesthesia covering the physiological and pharmacological effects on the eye, and its use for numerous subspecialty surgical procedures including for examination and diagnosis, for paediatric surgeries, vitreoretinal surgery, glaucoma, emergency eye surgery and more. The final section is dedicated to the causes and management of chronic ophthalmic pain. Each chapter features an abstract and 'nuggets of wisdom' providing useful points on the topic. Nearly 200 clinical images and tables enhance learning. Key Points Comprehensive guide to ophthalmic anaesthesia covering types, techniques, effects and complications Discusses both regional and general anaesthesia for numerous ocular surgeries Includes chapters on emergencies in ocular surgical procedures Each chapter includes an abstract and 'nuggets of wisdom'

This extensive and yet easy-to-read book covers technical aspects of the management of difficult acute cholecystitis. It discusses diagnostic evaluation, treatment, and strategies for avoiding and managing complications based on both evidence-based data and the experiences of the editor and the international contributors. Further, it analyses the latest guidelines to find the best clinical applications. Each chapter describes the current diagnostic and management strategies, focusing on a possible risk stratification by scores proposed in literature. Lastly, the book describes the relevant technical considerations and tips and tricks, explaining them in full. Illustrated throughout and including line graphs depicting fundamental anatomic and technical principles, making it easy-to understand, it is a useful toolkit for all residents, fellows and general surgeons needing a guide to the treatment of difficult acute cholecystits.

Oxford Specialist Handbooks in Anaesthesia offer a concise, didactic way for medical and nursing staff to access practical management advice that is portable, accessible, and reliable. Anaesthesia for Emergency Care provides essential information for trainees, staff doctors, and consultants who are expected to anaesthetize patients for emergency surgery and other life-saving interventions. It includes concise advice on providing anaesthesia in the operating suite and in other locations, such as the emergency department, radiology department, and out of hospital. The book supports the curriculum for the CCT in Anaesthetics and covers many items across all three levels of the Royal College of Anaesthetists CPD matrix.