Propelled by the success of the sequencing of the human and many related genomes, molecular and cellular biology has delivered significant scientific breakthroughs. Mathematics (broadly defined) continues to play a major role in this effort, helping to discover the secrets of life by working collaboratively with bench biologists, chemists and physicists.

Because of its outstanding record of interdisciplinary research and training, the IMA was an ideal venue for the 2007-2008 IMA thematic year on Mathematics of Molecular and Cellular Biology. The kickoff event for this thematic year was a tutorial on Mathematics of Nucleic Acids, followed by the workshop Mathematics of Molecular and Cellular Biology, held September 15--21 at the IMA. This volume is dedicated to the memory of Nicholas R. Cozzarelli, a dynamic leader who fostered research and training at the interface between mathematics and molecular biology. It contains a personal remembrance of Nick Cozzarelli, plus 15 papers contributed by workshop speakers. The papers give an overview of state-of-the-art mathematical approaches to the understanding of DNA structure and function, and the interaction of DNA with proteins that mediate vital life processes.

This book presents fractional difference, integral, differential, evolution equations and inclusions, and discusses existence and asymptotic behavior of their solutions. Controllability and relaxed control results are obtained. Combining rigorous deduction with abundant examples, it is of interest to nonlinear science researchers using fractional equations as a tool, and physicists, mechanics researchers and engineers studying relevant topics. Contents Fractional Difference Equations Fractional Integral Equations Fractional Differential Equations Fractional Evolution Equations: Continued Fractional Differential Inclusions

Commutative Algebra, Singularities and Computer Algebra presents current trends in commutative algebra, algebraic combinatorics, singularity theory and computer algebra, and highlights the interaction between these disciplines. Contributions by leading international mathematicians thoroughly discuss topics in: modules theory, integrally closed ideals and determinantal ideals, singularities in projective spaces and Castelnuovo-Mumford regularity, Groebner and SAGBI basis, and the use of the computer packages Bergman, CoCoA and SINGULAR.

The aim of this volume is to present the state of the art in the mathematical analysis of transport and mixing phenomena in fluids and associated problems. It supplements current literature on the subject with a unique blend of contributions that touch upon both theoretical as well as modeling questions and showcase a variety of techniques, from the analysis of partial differential equations, to harmonic analysis, to computational methods. The volume contains the expanded notes from lectures by leading experts in the field at the Summer School "Transport, Fluids, and Mixing" held in Levico Terme, Italy, July 19-24, 2015.

This handbook is volume II in a series collecting mathematical state-of-the-art surveys in the field of dynamical systems. Much of this field has developed from
interactions with other areas of science, and this volume shows how concepts of dynamical systems further the understanding of mathematical issues that arise in applications. Although modeling issues are addressed, the central theme is the mathematically rigorous investigation of the resulting differential equations and their dynamic behavior. However, the authors and editors have made an effort to ensure readability on a non-technical level for mathematicians from other fields and for other scientists and engineers.

The eighteen surveys collected here do not aspire to encyclopedic completeness, but present selected paradigms. The surveys are grouped into those emphasizing finite-dimensional methods, numerics, topological methods, and partial differential equations. Application areas include the dynamics of neural networks, fluid flows, nonlinear optics, and many others.

While the survey articles can be read independently, they deeply share recurrent themes from dynamical systems. Attractors, bifurcations, center manifolds, dimension reduction, ergodicity, homoclinicity, hyperbolicity, invariant and inertial manifolds, normal forms, recurrence, shift dynamics, stability, to name
just a few, are ubiquitous dynamical concepts throughout the articles.

The topic of the 2010 Abel Symposium, hosted at the Norwegian Academy of Science and Letters, Oslo, was Nonlinear Partial Differential Equations, the study of which is of fundamental importance in mathematics and in almost all of natural sciences, economics, and engineering. This area of mathematics is currently in the midst of an unprecedented development worldwide. Differential equations are used to model phenomena of increasing complexity, and in areas that have traditionally been outside the realm of mathematics. New analytical tools and numerical methods are dramatically improving our understanding of nonlinear models. Nonlinearity gives rise to novel effects reflected in the appearance of shock waves, turbulence, material defects, etc., and offers challenging mathematical problems. On the other hand, new mathematical developments provide new insight in many applications. These proceedings present a selection of the latest exciting results by world leading researchers.

Analytical solutions to the orbital motion of celestial objects have been nowadays mostly replaced by numerical solutions, but they are still irreplaceable whenever speed is to be preferred to accuracy, or to simplify a dynamical model. In this book, the most common orbital perturbations problems are discussed according to the Lie transforms method, which is the de facto standard in analytical orbital motion calculations.

The book contains seven refereed research papers on locally compact quantum groups and groupoids by leading experts in the respective fields. These contributions are based on talks presented on the occasion of the meeting between mathematicians and theoretical physicists held in Strasbourg from February 21 to February 23, 2002. Topics covered are: various constructions of locally compact quantum groups and their multiplicative unitaries; duality theory for locally compact quantum groups; combinatorial quantization of flat connections associated with SL(2,c); quantum groupoids, especially coming from Depth 2 Extensions of von Neumann algebras, C*-algebras and Rings. Many mathematical results are motivated by problems in theoretical physics. Historical remarks set the results presented in perspective. Directed at research mathematicians and theoretical physicists as well as graduate students, the volume will give an overview of a field of research in which great progress has been achieved in the last few years, with new ties to many other areas of mathematics and physics.

The Inverse and Ill-Posed Problems Series is a series of monographs publishing postgraduate level information on inverse and ill-posed problems for an international readership of professional scientists and researchers. The series aims to publish works which involve both theory and applications in, e.g., physics, medicine, geophysics, acoustics, electrodynamics, tomography, and ecology.

From cell division to heartbeat, clocklike rhythms pervade the activities of every living organism. The cycles of life are ultimately biochemical in mechanism but many of the principles that dominate their orchestration are essentially mathematical. The Geometry of Biological Time describes periodic processes in living systems and their non-living analogues in the abstract terms of nonlinear dynamics. Enphasis is given in phase singularities, waves, and mutual synchronization in tissues composed of many clocklike units. Also provided are descriptions of the best-studied experimental systems such as chemical oscillators, pacemaker neurons, circadian clocks, and excitable media organized into biochemical and bioelectrical wave patterns in two and three dimensions. No theoretical background is assumed; the required notions are introduced through an extensive collection of pictures and easily understood examples. This extensively updated new edition incorporates the fruits of two decades' further exploration guided by the same principles. Limit cycle theories of circadian clocks are now applied to human jet lag and are understood in terms of the molecular genetics of their recently discovered mechanisms. Supercomputers reveal the unforeseen architecture and dynamics of three-dimensional scroll waves in excitable media. Their role in life-threatening electrical aberrations of the heartbeat is exposed by laboratory experiments and corroborated in the clinic. These developments trace back to three basic mathematical ideas.

This book collects the works presented at the 8th International Conference on Complex Networks (CompleNet) 2017 in Dubrovnik, Croatia, on March 21-24, 2017. CompleNet aims at bringing together researchers and practitioners working in areas related to complex networks. The past two decades has witnessed an exponential increase in the number of publications within this field. From biological systems to computer science, from economic to social systems, complex networks are becoming pervasive in many fields of science. It is this interdisciplinary nature of complex networks that CompleNet aims at addressing. The last decades have seen the emergence of complex networks as the language with which a wide range of complex phenomena in fields as diverse as physics, computer science, and medicine (to name a few) can be properly described and understood. This book provides a view of the state-of-the-art in this dynamic field and covers topics such as network controllability, social structure, online behavior, recommendation systems, and network structure.

This timely book deals with a current topic, i.e. the applications of metaheuristic algorithms, with a primary focus on optimization problems in civil engineering. The first chapter offers a concise overview of different kinds of metaheuristic algorithms, explaining their advantages in solving complex engineering problems that cannot be effectively tackled by traditional methods, and citing the most important works for further reading. The remaining chapters report on advanced studies on the applications of certain metaheuristic algorithms to specific engineering problems. Genetic algorithm, bat algorithm, cuckoo search, harmony search and simulated annealing are just some of the methods presented and discussed step by step in real-application contexts, in which they are often used in combination with each other. Thanks to its synthetic yet meticulous and practice-oriented approach, the book is a perfect guide for graduate students, researchers and professionals willing to applying metaheuristic algorithms in civil engineering and other related engineering fields, such as mechanical, transport and geotechnical engineering. It is also a valuable aid for both lectures and advanced engineering students.

This volume reflects the state of the art of numerical simulation of transitional and turbulent flows and provides an active forum for discussion of recent developments in simulation techniques and understanding of flow physics. Following the tradition of earlier DLES workshops, these papers address numerous theoretical and physical aspects of transitional and turbulent flows. At an applied level it contributes to the solution of problems related to energy production, transportation, magneto-hydrodynamics and the environment. A special session is devoted to quality issues of LES. The ninth Workshop on 'Direct and Large-Eddy Simulation' (DLES-9) was held in Dresden, April 3-5, 2013, organized by the Institute of Fluid Mechanics at Technische Universitat Dresden. This book is of interest to scientists and engineers, both at an early level in their career and at more senior levels.

The Palm theory and the Loynes theory of stationary systems are the two pillars of the modern approach to queuing. This book, presenting the mathematical foundations of the theory of stationaryqueuing systems, contains a thorough treatment of both of these.

This approach helps to clarify the picture, in that it separates the task of obtaining the key system formulas from that of proving convergence to a stationary state and computing its law.

The theory is constantly illustrated by classical results and models: Pollaczek-Khintchin and Tacacs formulas, Jackson and Gordon-Newell networks, multiserver queues, blocking queues, loss systems etc., but it also contains recent and significant examples, where the tools developed turn out to be indispensable.

Several other mathematical tools which are useful within this approach are also presented, such as the martingale calculus for point processes, or stochastic ordering for stationary recurrences.

This thoroughly revised second edition contains substantial additions - in particular, exercises and their solutions - rendering this now classic reference suitable for use as a textbook.

This second edition is an enlarged, completely updated, and extensively revised version of the authoritative first edition. It is devoted to the detailed study of illuminating specific problems of nonlinear elasticity, directed toward the scientist, engineer, and mathematician who wish to see careful treatments of precisely formulated problems. Special emphasis is placed on role of nonlinear material response. The mathematical tools from nonlinear analysis are given self-contained presentations where they are needed. This book begins with chapters on (geometrically exact theories of) strings, rods, and shells, and on the applications of bifurcation theory and the calculus of variations to problems for these bodies. The book continues with chapters on tensors, three-dimensional continuum mechanics, three-dimensional elasticity, large-strain plasticity, general theories of rods and shells, and dynamical problems. Each chapter contains a wealth of interesting, challenging, and tractable exercises.

This book covers high-transition temperature (Tc) s-wave superconductivity and the neighboring Mott insulating phase in alkali-doped fullerides. The author presents (1) a unified theoretical description of the phase diagram and (2) a nonempirical calculation of Tc. For these purposes, the author employs an extension of the DFT+DMFT (density-functional theory + dynamical mean-field theory). He constructs a realistic electron-phonon-coupled Hamiltonian with a newly formulated downfolding method. The Hamiltonian is analyzed by means of the extended DMFT. A notable aspect of the approach is that it requires only the crystal structure as a priori knowledge. Remarkably, the nonempirical calculation achieves for the first time a quantitative reproduction of the experimental phase diagram including the superconductivity and the Mott phase. The calculated Tc agrees well with the experimental data, with the difference within 10 K. The book provides details of the computational scheme, which can also be applied to other superconductors and other phonon-related topics. The author clearly describes a superconducting mechanism where the Coulomb and electron -phonon interactions show an unusual cooperation in the superconductivity thanks to the Jahn-Teller nature of the phonons.

This volume presentsa selection of survey and research articles based on invited lectures and contributed talks presented at the Workshop on Fluid Dynamics in Porous Media that was held in Coimbra, Portugal, inSeptember 12-14, 2011. The contributions are devoted to mathematical modeling, numerical simulation and their applications, providing the readers a state-of-the-art overview on the latest findings and new challenges on the topic. The book includes research work of worldwide recognized leaders in their respective fields and presents advances in both theory and applications, making it appealing to a vast range of audience, in particular mathematicians, engineers and physicists."

Based on the author's lecture notes and research, this well-illustrated and comprehensive text is one of the first to provide an introduction to image registration with particular emphasis on numerical methods in medical imaging. Ideal for researchers in industry and academia, it is also a suitable study guide for graduate mathematicians, computer scientists, engineers, medical physicists, and radiologists. Image registration is utilised whenever information obtained from different viewpoints needs to be combined or compared and unwanted distortion needs to be eliminated. For example, CCTV images, ultrasound images, brain scan images, fingerprint and retinal scanning. Modersitzki's book provides a systematic introduction to the theoretical, practical, and numerical aspects of image registration, with special emphasis on medical applications. Various techniques are described, discussed and compared using numerous illustrations. The text starts with an introduction to the mathematical principles and the motivating example of the Human Neuroscanning Project whose aim is to build an atlas of the human brain through reconstructing essential information out of deformed images of sections of a prepared brain. The introduction is followed by coverage of parametric image registrations such as landmark based, principal axes based, and optimal affine linear registration. Basic distance measures like sum of squared differences, correlation, and mutual information are also discussed. The next section is devoted to state-of-the-art non-parametric image registrations where general variational based framework for image registration is presented and used to describe and compare well-known and new image registration techniques. Finally, efficient numerical schemes for the underlying partial differential equations are presented and discussed. This text treats the basic mathematical principles, including aspects from approximation theory, image processing, numerics, partial differential equations, and statistics, with a strong focus on numerical methods in image processing. Providing a systematic and general framework for image registration, the book not only presents state-of-the-art concepts but also summarises and classifies the numerous techniques to be found in the literature.

This concise, fast-paced text introduces the concepts and applications behind plane networks. It presents fundamental material from linear algebra and differential equations, and offers several different applications of the continuous theory. Practical problems, supported by MATLAB files, underscore the theory; additional material can be downloaded from the author's website.

Static hedge portfolios for barrier options are very sensitive with respect to changes of the volatility surface. To prevent potentially significant hedging losses this book develops a static super-replication strategy with market-typical robustness against volatility, skew and liquidity risk as well as model errors. Empirical results and various numerical examples confirm that the static superhedge successfully eliminates the risk of a changing volatility surface. Combined with associated sub-replication strategies this leads to robust price bounds for barrier options which are also relevant in the context of dynamic hedging. The mathematical techniques used to prove appropriate existence, duality and convergence results range from financial mathematics, stochastic and semi-infinite optimization, convex analysis and partial differential equations to semidefinite programming.

Methods of global analysis and stochastic analysis are most often applied in mathematical physics as separate entities, thus forming important directions in the field. However, while combination of the two subject areas is rare, it is fundamental for the consideration of a broader class of problems.

This book develops methods of Global Analysis and Stochastic Analysis such that their combination allows one to have a more or less common treatment for areas of mathematical physics that traditionally are considered as divergent and requiring different methods of investigation.

Global and Stochastic Analysis with Applications to Mathematical Physics covers branches of mathematics that are currently absent in monograph form. Through the demonstration of new topics of investigation and results, both in traditional and more recent problems, this book offers a fresh perspective on ordinary and stochastic differential equations and inclusions (in particular, given in terms of Nelson's mean derivatives) on linear spaces and manifolds. Topics covered include classical mechanics on non-linear configuration spaces, problems of statistical and quantum physics, and hydrodynamics.

A self-contained book that provides a large amount of preliminary material and recent results which will serve to be a useful introduction to the subject and a valuable resource for further research. It will appeal to researchers, graduate and PhD students working in global analysis, stochastic analysis and mathematical physics.

This volume explores the emerging and current, cutting-edge theories and methods of modeling, optimization, dynamics and bio economy. It provides an overview of the main issues, results and open questions in these fields as well as covers applications to biology, economy, energy, industry, physics, psychology and finance.

The majority of the contributed papers for this volume come from the participants of the International Conference on Modeling, Optimization and Dynamics (ICMOD 2010), a satellite conference of EURO XXIV Lisbon 2010, which took place at Faculty of Sciences of University of Porto, Portugal and from the Berkeley Bio economy Conference 2012, at the University of California, Berkeley, USA.

The book focuses classical oligopoly theory as developed in 1840-1940. By the end of this period oligopoly came under the spell of game theory in its probabilistic equilibrium format. Work by Cournot, von Stackelberg, Palander, and Hotelling, causal and dynamic in essence, but ignored, is reconsidered in the light of modern dynamics using topology and numerics. As particular features, von Stackelberg leadership is included in the dynamic Cournot model, the Hotelling problem is solved with elastic demand, thus skipping the absurd idea of quadratic transportation costs. Further, it is shown that the celebrated destabilisation of Cournot equilibrium under increased competition is due to mistakenly assuming constant returns, and that the whole idea of rational expectations is untenable in dynamic oligopoly. Early original ideas in oligopoly theory, such as coexistence and multiplicity of attractors are focused again after many undeserved decades of oblivion.

This book introduces mathematicians, physicists, and philosophers to a new, coherent approach to theory and interpretation of quantum physics, in which classical and quantum thinking live peacefully side by side and jointly fertilize the intuition. The formal, mathematical core of quantum physics is cleanly separated from the interpretation issues. The book demonstrates that the universe can be rationally and objectively understood from the smallest to the largest levels of modeling. The thermal interpretation featured in this book succeeds without any change in the theory. It involves one radical step, the reinterpretation of an assumption that was virtually never questioned before - the traditional eigenvalue link between theory and observation is replaced by a q-expectation link: Objective properties are given by q-expectations of products of quantum fields and what is computable from these. Averaging over macroscopic spacetime regions produces macroscopic quantities with negligible uncertainty, and leads to classical physics. - Reflects the actual practice of quantum physics. - Models the quantum-classical interface through coherent spaces. - Interprets both quantum mechanics and quantum field theory. - Eliminates probability and measurement from the foundations. - Proposes a novel solution of the measurement problem.