DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive. This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?. A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.

These lecture notes are dedicated to the most recent theoretical applications of Black Hole solutions in high-energy physics. The main motivation of this volume is to present the latest black hole backgrounds that are relevant for gauge/gravity correspondence. Leading scientists in the field explain effective techniques for finding singular and cosmological solutions embedded in gauged supergravity, shedding light on underlying properties and symmetries. Starting from a basic level, the mathematical structures underlying black holes and cosmologies are revealed, helping the reader grasp the connection between theoretical approaches and physical observations with insights into possible future developments from both a theoretical and experimental point of view. The topics covered in this volume are based on lectures delivered during the "Theoretical Frontiers in Black Holes and Cosmology" school, held in Natal in June 2015.

This contributed volume presents computational models of diabetes that quantify the dynamic interrelationships among key physiological variables implicated in the underlying physiology under a variety of metabolic and behavioral conditions. These variables comprise for example blood glucose concentration and various hormones such as insulin, glucagon, epinephrine, norepinephrine as well as cortisol. The presented models provide a powerful diagnostic tool but may also enable treatment via long-term glucose regulation in diabetics through closed-look model-reference control using frequent insulin infusions, which are administered by implanted programmable micro-pumps. This research volume aims at presenting state-of-the-art research on this subject and demonstrating the potential applications of modeling to the diagnosis and treatment of diabetes. The target audience primarily comprises research and experts in the field but the book may also be beneficial for graduate students.

As it was already seen in the first volume of the present book, its guideline is precisely the mathematical model of mechanics. The classical models which we refer to are in fact models based on the Newtonian model of mechanics, on its five principles, i. e. : the inertia, the forces action, the action and reaction, the parallelogram and the initial conditions principle, respectively. Other models, e. g. , the model of attraction forces between the particles of a discrete mechanical system, are part of the considered Newtonian model. Kepler's laws brilliantly verify this model in case of velocities much smaller than the light velocity in vacuum. The non-classical models are relativistic and quantic. Mechanics has as object of study mechanical systems. The first volume of this book dealt with particle dynamics. The present one deals with discrete mechanical systems for particles in a number greater than the unity, as well as with continuous mechanical systems. We put in evidence the difference between these models, as well as the specificity of the corresponding studies; the generality of the proofs and of the corresponding computations yields a common form of the obtained mechanical results for both discrete and continuous systems. We mention the thoroughness by which the dynamics of the rigid solid with a fixed point has been presented. The discrete or continuous mechanical systems can be non-deformable (e. g.

In April 2007, the Deutsche Forschungsgemeinschaft (DFG) approved the Priority Program 1324 "Mathematical Methods for Extracting Quantifiable Information from Complex Systems." This volume presents a comprehensive overview of the most important results obtained over the course of the program. Mathematical models of complex systems provide the foundation for further technological developments in science, engineering and computational finance. Motivated by the trend toward steadily increasing computer power, ever more realistic models have been developed in recent years. These models have also become increasingly complex, and their numerical treatment poses serious challenges. Recent developments in mathematics suggest that, in the long run, much more powerful numerical solution strategies could be derived if the interconnections between the different fields of research were systematically exploited at a conceptual level. Accordingly, a deeper understanding of the mathematical foundations as well as the development of new and efficient numerical algorithms were among the main goals of this Priority Program. The treatment of high-dimensional systems is clearly one of the most challenging tasks in applied mathematics today. Since the problem of high-dimensionality appears in many fields of application, the above-mentioned synergy and cross-fertilization effects were expected to make a great impact. To be truly successful, the following issues had to be kept in mind: theoretical research and practical applications had to be developed hand in hand; moreover, it has proven necessary to combine different fields of mathematics, such as numerical analysis and computational stochastics. To keep the whole program sufficiently focused, we concentrated on specific but related fields of application that share common characteristics and as such, they allowed us to use closely related approaches.

This volume, setting out the theory of positive maps as it stands today, reflects the rapid growth in this area of mathematics since it was recognized in the 1990s that these applications of C*-algebras are crucial to the study of entanglement in quantum theory. The author, a leading authority on the subject, sets out numerous results previously unpublished in book form. In addition to outlining the properties and structures of positive linear maps of operator algebras into the bounded operators on a Hilbert space, he guides readers through proofs of the Stinespring theorem and its applications to inequalities for positive maps.

The text examines the maps positivity properties, as well as their associated linear functionals together with their density operators. It features special sections on extremal positive maps and Choi matrices. In sum, this is a vital publication that covers a full spectrum of matters relating to positive linear maps, of which a large proportion is relevant and applicable to today s quantum information theory. The latter sections of the book present the material in finite dimensions, while the text as a whole appeals to a wider and more general readership by keeping the mathematics as elementary as possible throughout."

This book describes a relatively new approach for the design of electromagnetic metamaterials. Numerical optimization routines are combined with electromagnetic simulations to tailor the broadband optical properties of a metamaterial to have predetermined responses at predetermined wavelengths. After a review of both the major efforts within the field of metamaterials and the field of mathematical optimization, chapters covering both gradient-based and derivative-free design methods are considered. Selected topics including surrogate-base optimization, adaptive mesh search, and genetic algorithms are shown to be effective, gradient-free optimization strategies. Additionally, new techniques for representing dielectric distributions in two dimensions, including level sets, are demonstrated as effective methods for gradient-based optimization. Each chapter begins with a rigorous review of the optimization strategy used, and is followed by numerous examples that combine the strategy with either electromagnetic simulations or analytical solutions of the scattering problem. Throughout the text, we address the strengths and limitations of each method, as well as which numerical methods are best suited for different types of metamaterial designs. This book is intended to provide a detailed enough treatment of the mathematical methods used, along with sufficient examples and additional references, that senior level undergraduates or graduate students who are new to the fields of plasmonics, metamaterials, or optimization methods; have an understanding of which approaches are best-suited for their work and how to implement the methods themselves.

The book provides strong evidence that research on the cognitive processes from arithmetic thought to algebraic thought should take into consideration the socio-cultural context. It is an important contribution to the literature on linguistic structure in comparative studies related to Chinese student mathematics learning.

This book not only makes a great contribution to research in mathematics education, the findings of this study also addressed insightful approaches and thoughts of understanding the development of algebraic thinking in cultural contexts for classroom teachers. Using written Chinese language from different theoretical references provided wonderful approaches for understanding student algebra cognitive development in a different way and calls educators for to pay special attention to an epistemological and linguistic view of algebraic development. The findings inform classroom teachers that the cultural context plays an important role in student learning mathematics. A typical analysis of the cognitive dimension involved in some in the historical and cultural contexts is a great resource for classroom teachers.

I really enjoyed reading this book and learned a lot from its compelling analysis.

Shuhua An, Associate Professor and Director of Graduate Program in Mathematics Education, California State University, Long Beach

The book you hold in your hands is the outcome of the "2014 Interdisciplinary Symposium on Complex Systems" held in the historical city of Florence. The book consists of 37 chapters from 4 areas of Physical Modeling of Complex Systems, Evolutionary Computations, Complex Biological Systems and Complex Networks. All 4 parts contain contributions that give interesting point of view on complexity in different areas in science and technology. The book starts with a comprehensive overview and classification of complexity problems entitled Physics in the world of ideas: Complexity as Energy" , followed by chapters about complexity measures and physical principles, its observation, modeling and its applications, to solving various problems including real-life applications. Further chapters contain recent research about evolution, randomness and complexity, as well as complexity in biological systems and complex networks. All selected papers represent innovative ideas, philosophical overviews and state-of-the-art discussions on aspects of complexity. The book will be useful as an instructional material for senior undergraduate and entry-level graduate students in computer science, physics, applied mathematics and engineering-type work in the area of complexity. The book will also be valuable as a resource of knowledge for practitioners who want to apply complexity to solve real-life problems in their own challenging applications.

Here, the authors present modern mathematical methods to solve problems of differential-operator inclusions and evolution variation inequalities which may occur in fields such as geophysics, aerohydrodynamics, or fluid dynamics. For the first time, they describe the detailed generalization of various approaches to the analysis of fundamentally nonlinear models and provide a toolbox of mathematical equations. These new mathematical methods can be applied to a broad spectrum of problems. Examples of these are phase changes, diffusion of electromagnetic, acoustic, vibro-, hydro- and seismoacoustic waves, or quantum mechanical effects. This is the second of two volumes dealing with the subject.

These proceedings from the 2012 symposium on "Chaos, complexity and leadership" reflect current research results from all branches of Chaos, Complex Systems and their applications in Management. Included are the diverse results in the fields of applied nonlinear methods, modeling of data and simulations, as well as theoretical achievements of Chaos and Complex Systems. Also highlighted are Leadership and Management applications of Chaos and Complexity Theory.

This volume collects a selection of refereed papers of the more than one hundred presented at the InternationalConference MAF 2008 - Mathematicaland Statistical Methods for Actuarial Sciences and Finance. The conference was organised by the Department of Applied Mathematics and theDepartment ofStatisticsoftheUniversityCa'Foscari Venice(Italy), withthec- laborationofthe Department ofEconomics and StatisticalSciences ofthe University ofSalerno(Italy).Itwas heldinVenice, fromMarch 26to28,2008, attheprestigious CavalliFranchettipalace, alongGrand Canal, oftheIstitutoVenetodiScienze, Lettere ed Arti. This conference was the ?rst international edition of a biennial national series begunin2004, whichwas bornof thebrilliantbeliefofthe colleagues -and friends- oftheDepartmentofEconomicsandStatisticalSciences oftheUniversityofSalerno: the idea following which the cooperation between mathematicians and statisticians in working in actuarial sciences, in insurance and in ?nance can improve research on these topics. The proof of this consists in the wide participation in these events. In particular, with reference to the 2008 internationaledition: - More than 150 attendants, both academicians and practitioners; - More than 100 accepted communications, organised in 26 parallel sessions, from authors coming from about twenty countries (namely: Canada, Colombia, Czech Republic, France, Germany, Great Britain, Greece, Hungary, Ireland, Israel, Italy, Japan, Poland, Spain, Sweden, Switzerland, Taiwan, USA); - two plenary guest-organised sessions; and - aprestigiouskeynotelecturedeliveredbyProfessorWolfgangHa ]rdleoftheH- boldt Universityof Berlin (Germany)

This volume, dedicated to Carl Pearcy on the occasion of his 60th birthday, presents recent results in operator theory, nonselfadjoint operator algebras, measure theory and the theory of moments. The articles on these subjects have been contributed by leading area experts, many of whom were associated with Carl Pearcy as students or collaborators. The book testifies to his multifaceted interests and includes a biographical sketch and a list of publications.

This book collects the proceedings of the Algebra, Geometry and Mathematical Physics Conference, held at the University of Haute Alsace, France, October 2011. Organized in the four areas of algebra, geometry, dynamical symmetries and conservation laws and mathematical physics and applications, the book covers deformation theory and quantization; Hom-algebras and n-ary algebraic structures; Hopf algebra, integrable systems and related math structures; jet theory and Weil bundles; Lie theory and applications; non-commutative and Lie algebra and more.

The papers explore the interplay between research in contemporary mathematics and physics concerned with generalizations of the main structures of Lie theory aimed at quantization and discrete and non-commutative extensions of differential calculus and geometry, non-associative structures, actions of groups and semi-groups, non-commutative dynamics, non-commutative geometry and applications in physics and beyond.

The book benefits a broad audience of researchers and advanced students.

This book is an attempt to provide a uni?ed methodology to derive models for fatigue life. This includes S-N, ?-N and crack propagation models. This is not a conventional book aimed at describing the fatigue fundamentals, but rather a book in which the basic models of the three main fatigue approaches, the stress-based, the strain-based and the fracture mechanics approaches, are contemplated from a novel and integrated point of view. On the other hand, as an alternative to the preferential attention paid to deterministic models based on the physical, phenomenological and empirical description of fatigue, their probabilistic nature is emphasized in this book, in which stochastic fatigue and crack growth models are presented. This book is the result of a long period of close collaborationbetween its two authors who, although of di?erent backgrounds, mathematical and mechanical, both have a strong sense of engineering with respect to the fatigue problem. When the authors of this book ?rst approached the fatigue ?eld in 1982 (twenty six years ago), they found the following scenario: 1. Linear, bilinear or trilinear models were frequently proposed by relevant laboratoriesandacademiccenterstoreproducetheW] ohler?eld. Thiswas the case of well known institutions, which justi?ed these models based on clientrequirementsorpreferences. Thisledtotheinclusionofsuchmodels and methods as, for example, the up-and-down, in standards and o?cial practical directives (ASTM, Euronorm, etc.), which have proved to be unfortunate."

This book deals with the problem of dynamics of bodies with time-variable mass and moment of inertia. Mass addition and mass separation from the body are treated. Both aspects of mass variation, continual and discontinual, are considered. Dynamic properties of the body are obtained applying principles of classical dynamics and also analytical mechanics. Advantages and disadvantages of both approaches are discussed. Dynamics of constant body is adopted, and the characteristics of the mass variation of the body is included. Special attention is given to the influence of the reactive force and the reactive torque. The vibration of the body with variable mass is presented. One and two degrees of freedom oscillators with variable mass are discussed. Rotors and the Van der Pol oscillator with variable mass are displayed. The chaotic motion of bodies with variable mass is discussed too. To support learning, some solved practical problems are included.

The series is designed to bring together those mathematicians who are seriously interested in getting new challenging stimuli from economic theories with those economists who are seeking effective mathematical tools for their research. A lot of economic problems can be formulated as constrained optimizations and equilibration of their solutions. Various mathematical theories have been supplying economists with indispensable machineries for these problems arising in economic theory. Conversely, mathematicians have been stimulated by various mathematical difficulties raised by economic theories.

This book explores finite element methods for incompressible flow problems: Stokes equations, stationary Navier-Stokes equations and time-dependent Navier-Stokes equations. It focuses on numerical analysis, but also discusses the practical use of these methods and includes numerical illustrations. It also provides a comprehensive overview of analytical results for turbulence models. The proofs are presented step by step, allowing readers to more easily understand the analytical techniques.

It is the aim of INDICES to document recent explorations in the various fields of philosophical logic and formal linguistics and their applications in other disciplines. The main emphasis of this series is on self-contained monographs covering particular areas of recent research and surveys of methods, problems, and results in all fields of inquiry where recourse to logical analysis and logical methods has been fruitful. INDICES will contain monographs dealing with the central areas of philosophical logic (extensional and intensional systems, indexical logics, non-classical logics, philosophy of logic, etc.) as well as studies in which these systems are applied to specific issues in philosophy, in the formal semantics of natural languages, the foundations of linguistic theory, in computational linguistics, and in theoretical computer science. Constructive type theory was first presented in 1970, by the Swedish logician Per Martin-Lof. It has become one of the main approaches used in the foundations of mathematics and computer science. But it has remained relatively unknown among linguists and philosophers, although it provides a considerable extension of the concepts and techniques of logic. The book first gives an introduction to type theory from the point of view of linguistics and the philosophy of language. Type theory is then applied in the areas of quantification, anaphora, temporal reference, and the structure of text and discourse. By virtue of the type-theoretical concepts of proof object and context, various phenomena of dependence and progression in language can be discussed in precise terms, and several well-known problems can be solved. A categorial grammar is presented togenerate formally a fragment of English, together with an example of a computer implementation.

Focuses on acquiring spatial models of physical environments through mobile robots

The robotic mapping problem is commonly referred to as SLAM (simultaneous localization and mapping).

3D maps are necessary to avoid collisions with complex obstacles and to self-localize in six degrees of freedom (x-, y-, z-position, roll, yaw and pitch angle)

New solutions to the 6D SLAM problem for 3D laser scans are proposed and a wide variety of applications are presented

This book explores the life and scientific legacy of Manfred Schroeder through personal reflections, scientific essays and Schroeder s own memoirs. Reflecting the wide range of Schroeder s activities, the first part of the book contains thirteen articles written by his colleagues and former students. Topics discussed include his early, pioneering contributions to the understanding of statistical room acoustics and to the measurement of reverberation time; his introduction of digital signal processing methods into acoustics; his use of ray tracing methods to study sound decay in rooms and his achievements in echo and feedback suppression and in noise reduction. Other chapters cover his seminal research in speech processing including the use of predictive coding to reduce audio bandwidth which led to various code-excited linear prediction schemes, today used extensively for speech coding. Several chapters discuss Schroeder s work in low-peak factor signals, number theory, and maximum-length sequences with key applications in hearing research, diffraction gratings, artificial reverberators and de-correlation techniques for enhancing subjective envelopment in surround sound. In style, the articles range from truly scientific to conversationally personal. In all contributions, the relationship between the current research presented and Manfred Schroeder s own fields of interest is, in general, evident. The second part of the book consists of Schroeder s own memoirs, written over the final decade of his life. These recollections shed light on many aspects not only of Schroeder s life but also on that of many of his colleagues, friends and contemporaries. They portray political, social and scientific events over a period that extends from pre-war to the present. These memoirs, written in an inimitable and witty style, are full of information, entertaining and fun to read, providing key insight into the life and work of one of the greatest acousticians of the 20th century."

The revised edition of this advanced textbook provides the reader with a solid grounding in the formalism of classical mechanics, underlying a number of powerful mathematical methods that are widely used in modern theoretical and mathematical physics. It reviews the fundamentals of Lagrangian and Hamiltonian mechanics, and goes on to cover related topics such as canonical transformations, integral invariants, potential motion in geometric setting, symmetries, the Noether theorem and systems with constraints. While in some cases the formalism is developed beyond the traditional level adopted in the standard textbooks on classical mechanics, only elementary mathematical methods are used in the exposition of the material. New material for the revised edition includes additional sections on the Euler-Lagrange equation, the Cartan two-form in Lagrangian theory, and Newtonian equations of motion in context of general relativity. Also new for this edition is the inclusion of problem sets and solutions to aid in the understanding of the material presented. The mathematical constructions involved are explicitly described and explained, so the book is a good starting point for the student new to this field. Where possible, intuitive motivations are replaced by explicit proofs and direct computations, preserving the level of rigor that makes the book useful for more advanced students intending to work in one of the branches of the vast field of theoretical physics. To illustrate how classical-mechanics formalism works in other branches of theoretical physics, examples related to electrodynamics, as well as to relativistic and quantum mechanics, are included.

This thesis provides an introduction to the physics of the Standard Model and beyond, and to the methods used to analyse Large Hadron Collider (LHC) data. The 'hierarchy problem', astrophysical data and experiments on neutrinos indicate that new physics can be expected at the now accessible TeV scale. This work investigates extensions of the Standard Model with gravitons and gravitinos (in the context of supergravity). The production of these particles in association with jets is studied as one of the most promising avenues for researching new physics at the LHC. Advanced simulation techniques and tools, such as algorithms allowing the computation of Feynman graphs and helicity amplitudes are first developed and then employed.

In the present work, the target station of the accelerator-driven neutron source HBS is optimized in comprehensive parameter studies using the Monto-Carlo method. The dependence of the most important performance characteristics of such a system on the external parameters is investigated neglecting technical and mechanical limitations. In this way, qualitative and quantitative statements for all possible configurations and envisaged applications can be derived and should be considered in the detailed planning of such facilities. For this purpose, different scenarios are considered that place completely different requirements on the design of the target station. The central statements derived in this thesis can be transferred to any framework conditions, such as different accelerator energies, so that these results can be used in the development of other neutron sources, which together with the HBS form a European network and provide a prosperous community in neutron science.

This monograph presents recursion theory from a generalized point of view centered on the computational aspects of definability. A major theme is the study of the structures of degrees arising from two key notions of reducibility, the Turing degrees and the hyperdegrees, using techniques and ideas from recursion theory, hyperarithmetic theory, and descriptive set theory. The emphasis is on the interplay between recursion theory and set theory, anchored on the notion of definability. The monograph covers a number of fundamental results in hyperarithmetic theory as well as some recent results on the structure theory of Turing and hyperdegrees. It also features a chapter on the applications of these investigations to higher randomness.