This textbook provides a concise introduction and useful overview of the field of human population genomics, making the highly technical and contemporary aspects more accessible to students and researchers from various fields. Over the past decade, there has been a deluge of genetic variation data from the entire genome of individuals from many populations. These data have allowed an unprecedented look at human history and how natural selection has impacted humans during this journey. Simultaneously, there have been increased efforts to determine how genetic variation affects complex traits in humans. Due to technological and methodological advances, progress has been made at determining the architecture of complex traits. Split in three parts, the book starts with the basics, followed by more advanced and current research. The first part provides an introduction to essential concepts in population genetics, which are relevant for any organism. The second part covers the genetics of complex traits in humans. The third part focuses on applying these techniques and concepts to genetic variation data to learn about demographic history and natural selection in humans. This new textbook aims to serve as a gateway to modern human population genetics research for those new to the field. It provides an indispensable resource for students, researchers and practitioners from disparate areas of expertise.

The book covers fundamentals of the theory of optimal methods for solving ill-posed problems, as well as ways to obtain accurate and accurate-by-order error estimates for these methods. The methods described in the current book are used to solve a number of inverse problems in mathematical physics. Contents Modulus of continuity of the inverse operator and methods for solving ill-posed problems Lavrent'ev methods for constructing approximate solutions of linear operator equations of the first kind Tikhonov regularization method Projection-regularization method Inverse heat exchange problems

This book provides a comprehensive overview of different biomedical data types, including both clinical and genomic data. Thorough explanations enable readers to explore key topics ranging from electrocardiograms to Big Data health mining and EEG analysis techniques. Each chapter offers a summary of the field and a sample analysis. Also covered are telehealth infrastructure, healthcare information association rules, methods for mass spectrometry imaging, environmental biodiversity, and the global nonlinear fitness function for protein structures. Diseases are addressed in chapters on functional annotation of lncRNAs in human disease, metabolomics characterization of human diseases, disease risk factors using SNP data and Bayesian methods, and imaging informatics for diagnostic imaging marker selection. With the exploding accumulation of Electronic Health Records (EHRs), there is an urgent need for computer-aided analysis of heterogeneous biomedical datasets. Biomedical data is notorious for its diversified scales, dimensions, and volumes, and requires interdisciplinary technologies for visual illustration and digital characterization. Various computer programs and servers have been developed for these purposes by both theoreticians and engineers. This book is an essential reference for investigating the tools available for analyzing heterogeneous biomedical data. It is designed for professionals, researchers, and practitioners in biomedical engineering, diagnostics, medical electronics, and related industries.

This work uses techniques of optimization and operations research to develop the first comprehensive survey of the entire field of the optimization of resource, production, and distribution systems. Sten Thore proposes an "economic logistics" that is similar to the well-known concept of military logistics, but which is expanded to include such features as the optimal location of plants, inventories and retail outlets, and the management of hierarchical multi-echelon production, inventory, and distribution systems. The study of individual features of this supply process is familiar from operations research, but Thore joins these elements together into larger analytic structures encompassing the production and distribution system in an entire industry. Following an introductory chapter and a review of the saddle-point theory, coauthored with W. W. Cooper, Thore explores the three dimensions of the supply process synthesis: the spatial dimension (as in simple transportation systems), the vertical dimension (extending from resources to finished consumer goods, as in activity analysis), and the time dimension (as in inventory accumulation and investment). The combination of these then leads to models of such diverse subjects as regional warehouse systems, activity analysis and activity networks, multi-stage warehouse systems of intermediate goods, distribution networks, and spatial equilibrium. Each chapter contains its own exercises which are solved numerically and discussed in great detail, and illustrate such optimization techniques as linear and nonlinear programming, goal programming and goal focusing, chance-constrained programming, and infinite games. This work is designed for use ingraduate courses in economics and mathematics modeling, and will also be a useful addition to college and university library collections.

The present volume contains the Proceedings of the International Conference on Spectral Theory and Mathematical Physics held in Santiago de Chile in November 2014. Main topics are: Ergodic Quantum Hamiltonians, Magnetic Schroedinger Operators, Quantum Field Theory, Quantum Integrable Systems, Scattering Theory, Semiclassical and Microlocal Analysis, Spectral Shift Function and Quantum Resonances. The book presents survey articles as well as original research papers on these topics. It will be of interest to researchers and graduate students in Mathematics and Mathematical Physics.

Provides the necessary skills to solve problems in mathematical statistics through theory, concrete examples, and exercises With a clear and detailed approach to the fundamentals of statistical theory, Examples and Problems in Mathematical Statistics uniquely bridges the gap between theory andapplication and presents numerous problem-solving examples that illustrate the relatednotations and proven results. Written by an established authority in probability and mathematical statistics, each chapter begins with a theoretical presentation to introduce both the topic and the important results in an effort to aid in overall comprehension. Examples are then provided, followed by problems, and finally, solutions to some of the earlier problems. In addition, Examples and Problems in Mathematical Statistics features: * Over 160 practical and interesting real-world examples from a variety of fields including engineering, mathematics, and statistics to help readers become proficient in theoretical problem solving * More than 430 unique exercises with select solutions * Key statistical inference topics, such as probability theory, statistical distributions, sufficient statistics, information in samples, testing statistical hypotheses, statistical estimation, confidence and tolerance intervals, large sample theory, and Bayesian analysis Recommended for graduate-level courses in probability and statistical inference, Examples and Problems in Mathematical Statistics is also an ideal reference for applied statisticians and researchers.

This book explores the use of numerical relativity (NR) methods to solve cosmological problems, and describes one of the first uses of NR to study inflationary physics. NR consists in the solution of Einstein's Equation of general relativity, which governs the evolution of matter and energy on cosmological scales, and in systems where there are strong gravitational effects, such as around black holes. To date, NR has mainly been used for simulating binary black hole and neutron star mergers like those detected recently by LIGO. Its use as a tool in fundamental problems of gravity and cosmology is novel, but rapidly gaining interest. In this thesis, the author investigates the initial condition problem in early universe cosmology - whether an inflationary expansion period could have "got going" from initially inhomogeneous conditions - and identifies criteria for predicting the robustness of particular models. State-of-the-art numerical relativity tools are developed in order to address this question, which are now publicly available.

The book discusses three classes of problems: the generalized Nash equilibrium problems, the bilevel problems and the mathematical programming with equilibrium constraints (MPEC). These problems interact through their mathematical analysis as well as their applications. The primary aim of the book is to present the modern tool of variational analysis and optimization, which are used to analyze these three classes of problems. All contributing authors are respected academicians, scientists and researchers from around the globe. These contributions are based on the lectures delivered by experts at CIMPA School, held at the University of Delhi, India, from 25 November-6 December 2013, and peer-reviewed by international experts. The book contains five chapters. Chapter 1 deals with nonsmooth, nonconvex bilevel optimization problems whose feasible set is described by using the graph of the solution set mapping of a parametric optimization problem. Chapter 2 describes a constraint qualification to MPECs considered as an application of calmness concept of multifunctions and is used to derive M-stationarity conditions for MPEC. Chapter 3 discusses the first- and second-order optimality conditions derived for a special case of a bilevel optimization problem in which the constraint set of the lower level problem is described as a general compact convex set. Chapter 4 concentrates the results of the modelization and analysis of deregulated electricity markets with a focus on auctions and mechanism design. Chapter 5 focuses on optimization approaches called reflection methods for protein conformation determination within the framework of matrix completion. The last chapter (Chap. 6) deals with the single-valuedness of quasimonotone maps by using the concept of single-directionality with a special focus on the case of the normal operator of lower semi-continuous quasiconvex functions.

This book presents a collection of invited research and review contributions on recent advances in (mainly) theoretical condensed matter physics, theoretical chemistry, and theoretical physics. The volume celebrates the 90th birthday of N.H. March (Emeritus Professor, Oxford University, UK), a prominent figure in all of these fields. Given the broad range of interests in the research activity of Professor March, who collaborated with a number of eminent scientists in physics and chemistry, the volume embraces quite diverse topics in physics and chemistry, at various dimensions and energy scales. One thread connecting all these topics is correlation in aggregated states of matter, ranging from nuclear physics to molecules, clusters, disordered condensed phases such as the liquid state, and solid state physics, and the various phase transitions, both structural and electronic, occurring therein. A final chapter leaps to an even larger scale of matter aggregation, namely the universe and gravitation. A further no less important common thread is methodological, with the application of theoretical physics and chemistry, particularly density functional theory and statistical field theory, to both nuclear and condensed matter.

This monograph presents a broad treatment of developments in an area of constructive approximation involving the so-called "max-product" type operators. The exposition highlights the max-product operators as those which allow one to obtain, in many cases, more valuable estimates than those obtained by classical approaches. The text considers a wide variety of operators which are studied for a number of interesting problems such as quantitative estimates, convergence, saturation results, localization, to name several. Additionally, the book discusses the perfect analogies between the probabilistic approaches of the classical Bernstein type operators and of the classical convolution operators (non-periodic and periodic cases), and the possibilistic approaches of the max-product variants of these operators. These approaches allow for two natural interpretations of the max-product Bernstein type operators and convolution type operators: firstly, as possibilistic expectations of some fuzzy variables, and secondly, as bases for the Feller type scheme in terms of the possibilistic integral. These approaches also offer new proofs for the uniform convergence based on a Chebyshev type inequality in the theory of possibility. Researchers in the fields of approximation of functions, signal theory, approximation of fuzzy numbers, image processing, and numerical analysis will find this book most beneficial. This book is also a good reference for graduates and postgraduates taking courses in approximation theory.

This book features selected papers presented at the Fourth International Conference on Nanoelectronics, Circuits and Communication Systems (NCCS 2018). Covering topics such as MEMS and nanoelectronics, wireless communications, optical communications, instrumentation, signal processing, the Internet of Things, image processing, bioengineering, green energy, hybrid vehicles, environmental science, weather forecasting, cloud computing, renewable energy, RFID, CMOS sensors, actuators, transducers, telemetry systems, embedded systems, and sensor network applications in mines, it offers a valuable resource for young scholars, researchers, and academics alike.

Few-body physics covers a rich and wide variety of phenomena, ranging from the very lowest energy scales of atomic and molecular physics to high-energy particle physics. The papers contained in the present volume provide an apercu of recent progress in the field from both the theoretical and experimental perspectives and are based on work presented at the "22nd International Conference on Few-Body Problems in Physics". This book is geared towards academics and graduate students involved in the study of systems which present few-body characteristics and those interested in the related mathematical and computational techniques.

The thesis presents a tool to create rubble pile asteroid simulants for use in numerical impact experiments, and provides evidence that the asteroid disruption threshold and the resultant fragment size distribution are sensitive to the distribution of internal voids. This thesis represents an important step towards a deeper understanding of fragmentation processes in the asteroid belt, and provides a tool to infer the interior structure of rubble pile asteroids. Most small asteroids are 'rubble piles' - re-accumulated fragments of debris from earlier disruptive collisions. The study of fragmentation processes for rubble pile asteroids plays an essential part in understanding their collisional evolution. An important unanswered question is "what is the distribution of void space inside rubble pile asteroids?" As a result from this thesis, numerical impact experiments can now be used to link surface features to the internal structure and therefore help to answer this question. Applying this model to asteroid Steins, which was imaged from close range by the Rosetta spacecraft, a large hill-like structure is shown to be most likely primordial, while a catena of pits can be interpreted as evidence for the existence of fracturing of pre-existing internal voids.

Rational extended thermodynamics (RET) is the theory that is applicable to nonequilibrium phenomena out of local equilibrium. It is expressed by the hyperbolic system of field equations with local constitutive equations and is strictly related to the kinetic theory with the closure method of the hierarchies of moment equations. The book intends to present, in a systematic way, new results obtained by RET of gases in both classical and relativistic cases, and it is a natural continuation of the book "Rational Extended Thermodynamics beyond the Monatomic Gas" by the same authors published in 2015. However, this book addresses much wider topics than those of the previous book. Its contents are as follows: RET of rarefied monatomic gases and of polyatomic gases; a simplified RET theory with 6 fields being valid far from equilibrium; RET where both molecular rotational and vibrational modes exist; mixture of gases with multi-temperature. The theory is applied to several typical topics (sound waves, shock waves, etc.) and is compared with experimental data. From a mathematical point of view, RET can be regarded as a theory of hyperbolic symmetric systems, of which it is possible to conduct a qualitative analysis. The book represents a valuable resource for applied mathematicians, physicists, and engineers, offering powerful models for many potential applications such as reentering satellites into the atmosphere, semiconductors, and nanoscale phenomena.

Composed of contributions from leading experts in quantum foundations, this volume presents viewpoints on a number of complex problems through informational, probabilistic, and mathematical perspectives and features novel mathematical models of quantum and subquantum phenomena. Rich with multi-disciplinary mathematical content, this book includes applications of partial differential equations in quantum field theory, differential geometry, oscillatory processes and vibrations, and Feynman integrals for quickly growing potential functions. Due to rapid growth in the field in recent years, this volume aims to promote interdisciplinary collaboration in the areas of quantum probability, information, communication and foundation, and mathematical physics. Many papers discuss complex yet novel problems that depart from the mainstream of quantum physical studies. Others devote explanation to fundamental problems of the conventional quantum theory, including its mathematical formalism. Overall, authors cover a diverse set of topics, including quantum and classical field theory and oscillatory processing, quantum mechanics from a Darwinian evolutionary perspective, and biological applications of quantum theory. Together in one volume, these essays will be useful to experts in the corresponding areas of quantum theory. Theoreticians, experimenters, mathematicians, and even philosophers in quantum physics and quantum probability and information theory can consider this book a valuable resource.

This is a book about the Hilbert space formulation of quantum mechanics and its measurement theory. It contains a synopsis of what became of the Mathematical Foundations of Quantum Mechanics since von Neumann's classic treatise with this title. Fundamental non-classical features of quantum mechanics-indeterminacy and incompatibility of observables, unavoidable measurement disturbance, entanglement, nonlocality-are explicated and analysed using the tools of operational quantum theory. The book is divided into four parts: 1. Mathematics provides a systematic exposition of the Hilbert space and operator theoretic tools and relevant measure and integration theory leading to the Naimark and Stinespring dilation theorems; 2. Elements develops the basic concepts of quantum mechanics and measurement theory with a focus on the notion of approximate joint measurability; 3. Realisations offers in-depth studies of the fundamental observables of quantum mechanics and some of their measurement implementations; and 4. Foundations discusses a selection of foundational topics (quantum-classical contrast, Bell nonlocality, measurement limitations, measurement problem, operational axioms) from a measurement theoretic perspective. The book is addressed to physicists, mathematicians and philosophers of physics with an interest in the mathematical and conceptual foundations of quantum physics, specifically from the perspective of measurement theory.

The book provides a comprehensive introduction and a novel mathematical foundation of the field of information geometry with complete proofs and detailed background material on measure theory, Riemannian geometry and Banach space theory. Parametrised measure models are defined as fundamental geometric objects, which can be both finite or infinite dimensional. Based on these models, canonical tensor fields are introduced and further studied, including the Fisher metric and the Amari-Chentsov tensor, and embeddings of statistical manifolds are investigated. This novel foundation then leads to application highlights, such as generalizations and extensions of the classical uniqueness result of Chentsov or the Cramer-Rao inequality. Additionally, several new application fields of information geometry are highlighted, for instance hierarchical and graphical models, complexity theory, population genetics, or Markov Chain Monte Carlo. The book will be of interest to mathematicians who are interested in geometry, information theory, or the foundations of statistics, to statisticians as well as to scientists interested in the mathematical foundations of complex systems.

Young traces the evolution of the term information from its general linguistic use into the mainstream of modern science, proposing an entirely new definition of information as a mass-energy phenomenon. He demonstrates that: information is in all cases a form phenomenon; both form and information are mass-energy rather than abstract phenomena; mind can be viewed as a mass-energy rather form-manipulating process; form constitutes a mechanism immanent in the physical universe via which mass-energy systems can communicate informationally and control their own energetic activities.

This book introduces the fundamentals of computer vision (CV), with a focus on extracting useful information from digital images and videos. Including a wealth of methods used in detecting and classifying image objects and their shapes, it is the first book to apply a trio of tools (computational geometry, topology and algorithms) in solving CV problems, shape tracking in image object recognition and detecting the repetition of shapes in single images and video frames. Computational geometry provides a visualization of topological structures such as neighborhoods of points embedded in images, while image topology supplies us with structures useful in the analysis and classification of image regions. Algorithms provide a practical, step-by-step means of viewing image structures. The implementations of CV methods in Matlab and Mathematica, classification of chapter problems with the symbols (easily solved) and (challenging) and its extensive glossary of key words, examples and connections with the fabric of CV make the book an invaluable resource for advanced undergraduate and first year graduate students in Engineering, Computer Science or Applied Mathematics. It offers insights into the design of CV experiments, inclusion of image processing methods in CV projects, as well as the reconstruction and interpretation of recorded natural scenes.

This book covers various algorithmic developments in the perfect reconstruction cosine/sine-modulated filter banks (TDAC-MDCT/MDST or MLT, MCLT, low delay MDCT, complex exponential/cosine/sine-modulated QMF filter banks), and near-perfect reconstruction QMF banks (pseudo-QMF banks) in detail, including their general mathematical properties, matrix representations, fast algorithms and various methods to integer approximations being recently a new transform technology for lossless audio coding. Each chapter will contain a number of examples and will conclude with problems and exercises. The book reflects the research efforts/activities and achieved results of the authors in the time period over the last 20 years.

This book - specifically developed as a novel textbook on elementary classical mechanics - shows how analytical and numerical methods can be seamlessly integrated to solve physics problems. This approach allows students to solve more advanced and applied problems at an earlier stage and equips them to deal with real-world examples well beyond the typical special cases treated in standard textbooks. Another advantage of this approach is that students are brought closer to the way physics is actually discovered and applied, as they are introduced right from the start to a more exploratory way of understanding phenomena and of developing their physical concepts. While not a requirement, it is advantageous for the reader to have some prior knowledge of scientific programming with a scripting-type language. This edition of the book uses Python, and a chapter devoted to the basics of scientific programming with Python is included. A parallel edition using Matlab instead of Python is also available. Last but not least, each chapter is accompanied by an extensive set of course-tested exercises and solutions.

This book covers important concepts and applications of contemporary physics. The book emphasizes logical development of the subject and attempts to maintain rigor in the analytical discussions. The text has been presented in a concise and lucid manner. A modern description of properties and interaction of particle is given along with discussions on topics such as cosmology, laser and applications. The concepts are illustrated by numerous worked examples. Selected problems given at the end of each chapter help students to evaluate their skills. The book with its simple style, comprehensive and up-to-date coverage is highly useful for physics students. The detailed coverage and pedagogical tools make this an ideal book also for the engineering students studying core courses in physics.

An increasing complexity of models used to predict real-world systems leads to the need for algorithms to replace complex models with far simpler ones, while preserving the accuracy of the predictions. This three-volume handbook covers methods as well as applications. This third volume focuses on applications in engineering, biomedical engineering, computational physics and computer science.

This book is a self-contained elementary study for nonsmooth analysis and optimization, and their use in solution of nonsmooth optimal control problems. The first part of the book is concerned with nonsmooth differential calculus containing necessary tools for nonsmooth optimization. The second part is devoted to the methods of nonsmooth optimization and their development. A proximal bundle method for nonsmooth nonconvex optimization subject to nonsmooth constraints is constructed. In the last part nonsmooth optimization is applied to problems arising from optimal control of systems covered by partial differential equations. Several practical problems, like process control and optimal shape design problems are considered.