Infectious diseases as a specialty suffers from many unique challenges stemming from lower salaries compared to other medical specialties and difficulty keeping the younger demographic within the field. With emerging infections, new diagnostic and research tools, and changing migration patterns, these problems are amplified; infectious disease specialists are in higher demand than ever with fewer and fewer specialists available to support patients and colleagues outside of the field. To meet these increasing challenges, it is vital for the workforce of the future to have the best training possible. This book aims to provide this support. As trainees, all physicians face clinical infectious disease scenarios on a daily basis. They receive basic training in common infections, giving them the tools needed for initial diagnostic studies and empiric treatment. This approach, however, still leaves them struggling with nuances of treating common infections, infections that masquerade as other diseases, rare infection, advanced diagnostics, complicating medical conditions, and a wide range of medical complexities. Important clinical microbiology details and host susceptibility risks will be highlighted when discussing uncommon infections. Each chapter begins by defining a distinct clinical infectious disease problem and the most common cause(s). The next section of each chapter identifies the key questions to consider, including other possible pathogens, medical history, alternate microbiologic diagnoses, instances of unexpected result. This book is the only academic text designed specifically to meet this challenge by targeting learners at all levels. To do this, the text incorporate 30-40 common clinical infectious disease scenarios in both adult and pediatric hosts. It includes easy-to-access "tips and tricks" for when to look further or consider possibilities that are unusual that is useful for someone who is new to the information or has limited experience within infectious diseases. The text heavily features teaching and learning tools, including call out boxes that prioritizes infectious etiologies, host risk factors, important microbiologic clues, and important clinical history clues. The text also includes review questions and quiz-like challenges to reinforce the concepts. Written by experts in the field Clinical Infectious Diseases is the most cutting-edge academic resource for all medical students, fellows, residents, and trainees, including infectious disease specialists in both adult and pediatric care, internal medicine specialists, and hospitalists.

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

'Consider the most common mosquito on Earth. This soft, little, dusty-brown insect is Culex Pipiens. You've seen her land on your arm. You have caught her just at the end of her feeding, her translucent belly swelling red with your very own blood. At such a moment, you can be forgiven for failing to notice what an elegant and hardy thing she is. But she is . . . ' No creature has touched directly the lives of more human beings than the mosquito. She has been a nuisance, a pollinator of plants and an angel of death all over the globe. And throughout history, much of our trouble with the mosquito has been caused by man himself. Professor Andrew Spielman has dedicated his life to understanding this insect. In Mosquito he tells the story of man's struggle to live with the mosquito, from the defeat of Sir Francis Drake's fleet, to the death of thousands of Frenchmen working on the Panama Canal and to the recent panic over the West Nile Virus in New York. And he shows us how we have accelerated the spread of disease, describing the catastrophic failures of mosquito control which have ensured that - even now - one person dies of malaria every twelve seconds.

"Antibody Fc" is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.

Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.
Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitroCovers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodiesColor illustrations enhance explanations of the immune system

Love and marriage, children and family, death and grief. Life touches everyone the same, but living under lockdown? It changes us alone. A man abroad wanders the stag-and-hen-strewn streets of Newcastle, as news of the virus at home asks him to question his next move. An exhausted nurse struggles to let go, having lost a much-loved patient in isolation. A middle-aged son, barred from his mother's funeral, wakes to an oncoming hangover of regret. Told with Doyle's signature warmth, wit and extraordinary eye for the richness that underpins the quiet of our lives, Life Without Children cuts to the heart of how we are all navigating loss, loneliness and the shifting of history underneath our feet. 'Life Without Children is boldly exhilarating, with its revelations of quiet love and the sheer charm of the characters' voices' Sunday Times 'Quietly devastating...shivers with emotion' Financial Times 'In the stripping away of everyday anxieties, the virus reveals what matters most, those qualities that are always at the heart of Doyle's fiction: love and connection' Observer 'Moving...and beautiful' Daily Mail

'The authors of this absorbing book have a strong command of detail, context and narrative structure... the results are impressively claustrophobic.' - Times Literary Supplement 'Gripping... The authors skillfully capture the fear and claustrophobia. A riveting real-life drama.' - Kirkus 'Cabin Fever is riveting, taut, and extensively researched. Smith and Franklin have written a page-turning adventure that will keep you reading late into the night.' - Martin Dugard, #1 New York Times bestselling author of Taking Paris 'A gripping account of how an invisible stowaway - the Covid-19 virus - transformed a fun-filled luxury cruise into an unimaginable nightmare.' - Sara Gay Forden, bestselling author of House of Gucci 'Extensive first-hand testimony and the authors' brisk, matter-of-fact style enrich this propulsive account of how a holiday cruise turned into a nightmare. Readers will be riveted.' - Publishers Weekly In early 2020, the world was on edge. An ominous virus was spreading and no one knew what the coming weeks would bring. Far from the hotspots, the cruise ship Zaandam was preparing to sail from Buenos Aires loaded with 1,200 passengers - British, American, Australian, European and South American tourists, plus 600 crew. Most passengers were over the age of 65. There was concern about the virus in the news but that was oceans away. Escaping to sea at the ends of the earth for a few weeks seemed like it might be a good option. The cruise line had said the voyage would go ahead as scheduled and it would be safe. Within days, people aboard the Zaandam began to fall sick. The world's ports shut down. Zaandam became a top story on the news and was denied safe harbour everywhere. With only two doctors aboard and few medical supplies to test for or treat Covid-19, and with dwindling food and water, the ship wandered the oceans on an unthinkable journey. Cabin Fever is a riveting narrative thriller, taking readers behind the scenes of the ship's complex workings, and below decks into the personal lives of passengers and crew who were caught unprepared for the deadly ordeal that lay ahead. It is a story layered with moments of peril, perseverance and kindness. A remarkable tale that is filled with individual acts of heroism and the struggles and the tragedies of the crew and passengers.

Bringing the hard-to-quantify aspects of lived experience to analysis, and emphasizing what might be lost in interventions if cultural insights are absent, this book includes case studies from across the Asia and Pacific regions -Bangladesh, Malaysia, New Guinea, Indonesia, Thailand, South Korea, Australia, New Zealand, Tuvalu and the Cook Islands. When Culture Impacts Health offers conceptual, methodological and practical insights into understanding and successfully mediating cultural influences to address old and new public health issues including safe water delivery, leprosy, Attention Deficit Hyperactivity Disorder and body image. It contains useful methodological tools - how to map cultural consensus, measure wealth capital, conduct a cultural economy audit, for example. It provides approaches for discerning between ethnic and racial constructs and for conducting research among indigenous peoples. The book will be indispensible for culture and health researchers in all regions.
Discusses global application of case descriptionsDemonstrates how a cultural approach to health research enriches and informs our understanding of intractable public health problemsCovers methods and measurements applicable to a variety of cultural research approaches as well as actual research resultsCase studies include medical anthropology, cultural epidemiology, cultural history and social medicine perspectives

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

As the outbreak of a new and deadly form of coronavirus dominates headlines and triggers fear and global recession, now is a good time to reflect on the history and science of transmissible diseases. Behind every disease is a story, from the natural history of the disease and its course in the individual, to the tale of the disease's description, discovery and treatment. From the impact of tuberculosis on English dynastic history to the makeup of our DNA; from the deadliest plagues of the ancient world to twenty-first century pandemics; and from the ravages of the Black Death to the discovery of antibodies, transmissible diseases have an incredible variety of tales to tell.

Contagion explores some of the most notorious, grisly, and pernicious communicable diseases in history, revealing their hidden stories. In addition to discussing their symptoms, causes, prevention, and treatment, Richard Gunderman also discusses their impact on notable figures in history, from soldiers to monarchs; the extraordinary contributions of the scientists and physicians who battled them; as well as their impacts on world history and human evolution. Here are the exploits of Edward Jenner, who invented the first vaccine; John Snow, the first person to study disease scientifically; Louis Pasteur, who established the germ theory of infection, along with a myriad other remarkable stories in the never ending struggle between humanity and disease. The narrative is brought right up to date with the desperate battle to stem the Covid-19 pandemic and discover a vaccine.

Renowned medical expert Dr Richard Gunderman shows how disease has shaped the evolution of our species and, if we don't take the proper steps, may yet threaten our very existence on this planet.

In the past few decades, there have been great advances in the phylogenetic classification of infectious diseases of man. "Taxonomic Guide to Infectious Diseases" organizes this information into a standard biological classification and provides a short, clinically-oriented description of every genus (class) of infectious organism. It covers an overview of modern taxonomy, including a description of the kingdoms of life and the evolutionary principles underlying the class hierarchy, and each following chapter will describe one phylum and the genera that contain infectious species. "Taxonomic Guide to Infectious Diseases" iswritten in an engaging, narrative style, providing the reader with an easy to digest yet clinically-oriented story of the pathogenic features of each genus. Designed for researchers, clinicians and students of infectious diseases, medical microbiology and pathology.
Offers genus-by-genus classification of infectious diseases along with short, clinically-oriented descriptions of each genusPresentscomprehensive lists of infectious species for each genera and identifies diseases caused by each speciesCompiled and written by a well-known pathologist with extensive experience in diagnosing human infectious diseases"

Thisthematic volume providesauthoritative, up-to-date reviews addressing recent advances as well as an overview for the research and clinical communities on the endemic infection of Chagas disease. Lead researchers discuss epidemiology and control measures as well as various diagnosis techniques, treatments, and therapies currently being used. The text includes a history of Chagas disease and an outlook for the next century.
Informs and updates on all the latest developments in the field Contributions from leading authorities and industry experts "

This thematic volume provides authoritative, up-to-date reviews addressing recent advances as well as an overview for the research and clinical communities on the endemic infection of Chagas disease. Lead researchers discuss epidemiology and control measures as well as various diagnosis techniques, treatments, and therapies currently being used. The text includes a history of Chagas disease and an outlook for the next century.

Informs and updates on all the latest developments in the field
Contributions from leading authorities and industry experts

Volume 79 of "Advances in Virus Research "focuses on developments surrounding rabies, an ancient disease that remains a prominent public health problem for humans. This volume highlights important research advances extending from our understanding of how the rabies virus replicates and assembles to how the disease can be prevented and treated in humans and how rabies can be controlled in wildlife hosts. Experts in the field provide insightful and up-to-date chapters that summarize our current state of knowledge in diverse aspects of this very interesting and important viral disease.

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

'A virtuoso feat ... a book of panoramic breadth' New York Times Book Review 'A devastating analysis ... Wright is a master of knitting together complex narratives' The Observer Just as Lawrence Wright's The Looming Tower became the defining account of our century's first devastating event, 9/11, so The Plague Year will become the defining account of the second. The story starts with the initial moments of Covid's appearance in Wuhan and ends with Joseph Biden's inauguration in an America ravaged by well over 400,000 deaths - a mortality already some ten times worse than US combat deaths in the entire Vietnam War. This is an anguished, furious memorial to a year in which all of America's great strengths - its scientific knowledge, its great civic and intellectual institutions, its spirit of voluntarism and community - were brought low, not by a terrifying new illness alone, but by political incompetence and cynicism on a scale for which there has been no precedent. With insight, sympathy, clarity and rage, The Plague Year allows the reader to see the unfolding of this great tragedy, talking with individuals on the front line, bringing together many moving and surprising stories and painting a devastating picture of a country literally and fatally misled. 'Maddening and sobering - as comprehensive an account of the first year of the pandemic as we've yet seen' Kirkus

This first of the three-volume tuberculosis book series provides a comprehensive overview of molecular biological and biochemical aspects of tuberculosis. Edited by the undisputed world leader in the field, this is the most comprehensive book on the topic available, and the first in recent years to focus on both basic research and clinical aspects of TB.

Viruses are a huge threat to agriculture. In the past, viruses used to be controlled using conventional methods, such as crop rotation and destruction of the infected plants, but now there are more novel ways to control them. This volume focuses on topics that must be better understood in order to foster future developments in basic and applied plant virology. These range from virus epidemiology and virus/host co-evolution and the control of vector-mediated transmission through to systems biology investigations of virus-cell interactions. Other chapters cover the current status of signalling in natural resistance and the potential for a revival in the use of cross-protection, as well as future opportunities for the deployment of the under-utilized but highly effective crop protection strategy of pathogen-derived resistance.
Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Effective public health strategies depend on surveillance, preventative measures, outbreak investigation and the institution of control measures including appropriate treatment. This handbook, written specifically for community nurses, describes the communicable diseases likely to be encountered by the community nurse and offers practical guidance on their assessment and treatment. The book looks at staff hygiene and a clean environment and examines the causes and management of blood-borne illnesses together with recommendations for the treatment of head lice, scabies and threadworms. The latter part of the book discusses the prevention of influenza and the rising incidence of tuberculosis and the care of patients with these conditions and considers other common infections such as MRSA, impetigo, shingles and meningitis.

This practical book covers all aspects of the biology of malaria vectors, with notes on the vectors of dengue. It is the first work in this field to concentrate on mosquitoes, rather than covering all disease vectors. Authored by renowned field entomologist Jacques Derek Charlwood, it disseminates his vast experience working on mosquito biology, ecology and the evaluation of new vector control tools across five continents over the past 40 years. Covering all aspects from classification and systematics, population dynamics, vector control, to surveillance and sampling, epidemics, and a selection of case histories, the book also considers genetics and resistance, Aedes biology, and malaria and dengue models. It is designed to fill the gap between very specialized texts and undergraduate books on general disease vectors, and is ideal as a textbook for postgraduate courses in entomology and mosquito vectors of disease.

Written from the perspective of the diagnostician, this bestselling book is the definitive text on the laboratory diagnosis of human viral diseases. It contains a wealth of illustrations, tables, and algorithms to enhance your understanding of this ever-evolving field. The book is a ready reference for virologists, microbiologists, epidemiologists, laboratorians, and infections disease specialists, and students.

Comprehensive in scope, yet concise and easy to manage, Principles and Practice of Pediatric Infectious Diseases, 6th Edition, by Drs. Sarah S. Long, Charles G. Prober, Marc Fischer, and new editor David Kimberlin, is your go-to resource for authoritative information on infectious diseases in children and adolescents. A veritable "who's who" of global authorities provides the practical knowledge you need to understand, diagnose, and manage almost any pediatric infectious disease you may encounter. Covers the latest aspects of the COVID-19 pandemic, including manifestations, diagnosis, management, and prevention of SARS-CoV-2 infection. Features an easy-access format with high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables. Allows quick look-up by clinical presentation, pathogen, or type of host. Highlights expanding antimicrobial resistance patterns and new therapies for viral and fungal infections and resistant bacterial infections. Includes coverage of the latest vaccine products, recommendations, and effectiveness. Reviews emerging healthcare-associated infections, their management, control, and prevention. Contains a new chapter on Chorioamnionitis and Neonatal Consequences. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Advances in Virus Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain. This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering: Influenza Perspectives Structure and Replication Evolution and Ecology Epidemiology and Surveillance Immunology Vaccines and Vaccine Development Clinical Aspects and Antivirals Public Health Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners.

A story of courage and risk-taking, "House on Fire" tells how smallpox, a disease that killed, blinded, and scarred millions over centuries of human history, was completely eradicated in a spectacular triumph of medicine and public health. Part autobiography, part mystery, the story is told by a man who was one of the architects of a radical vaccination scheme that became a key strategy in ending the horrible disease when it was finally contained in India. In "House on Fire", William H. Foege describes his own experiences in public health and details the remarkable program that involved people from countries around the world in pursuit of a single objective - eliminating smallpox forever. Rich with the details of everyday life, as well as a few adventures, "House on Fire" gives an intimate sense of what it is like to work on the ground in some of the world's most impoverished countries - and tells what it is like to contribute to programs that really do change the world.

**SHORTLISTED FOR THE WELLCOME BOOK PRIZE** **A GUARDIAN SCIENCE BOOK OF THE YEAR** 'Riveting ... invites comparison to Rebecca Skloot's The Immortal Life of Henrietta Lacks' Nature The epic and controversial story of a major breakthrough in cell biology that led to the conquest of rubella and other devastating diseases. Until the late 1960s, tens of thousands of children suffered crippling birth defects if their mothers had been exposed to rubella, popularly known as German measles, while pregnant. There was no vaccine and little understanding of how the disease devastated foetuses. In June 1962, a young biologist in Philadelphia produced the first safe, clean cells that made possible the mass-production of vaccines against many common childhood diseases. Two years later, in the midst of a German measles epidemic, his colleague developed the vaccine that would one day effectively wipe out rubella for good. This vaccine - and others made with those cells - have since protected hundreds of millions of people worldwide, the vast majority of them preschool children. Meredith Wadman's account of this great leap forward in medicine is a fascinating and revelatory read.

In Longshot, investigative journalist David Heath takes readers inside the small group of scientists whose groundbreaking work was once largely dismissed but whose feat will now eclipse the importance of Jonas Salk's polio vaccine in medical history. With never-before-reported details, Heath reveals how these scientists overcame countless obstacles to give the world an unprecedented head start when we needed a COVID-19 vaccine. The story really begins in the 1990s, with a series of discoveries that were timed perfectly to prepare us for the worst pandemic since 1918. Readers will meet Katalin Kariko, who made it possible to use messenger RNA in vaccines but struggled for years just to hang on to her job. There's also Derrick Rossi, who leveraged Kariko's work to found Moderna but was eventually expelled from his company. And then there's Barney Graham at the National Institutes of Health, who had a career-long obsession with solving the riddle of why two toddlers died in a vaccine trial in 1966, a tragedy that ultimately led to a critical breakthrough in vaccine science. With both foresight and luck, Graham and these other crucial scientists set the course for a coronavirus vaccine years before COVID-19 emerged in Wuhan, China. The author draws on hundreds of hours of interviews with key players to tell the definitive story about how the race to create the vaccine sparked a revolution in medical science.