In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy. Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem. Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ss-lactam antibiotics with ss-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.

Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul's Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It's an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role. Reflects the latest advances in the field, including current insights on immune system function, both basic and translational. Contains 50 chapters written by leaders in all subfields of immunology. Provides extensive coverage of the molecular biology that explains the dynamics underlying immune disorders and their treatment. Includes 10 entirely new chapters covering invertebrate and plant immunity, eosinophils, innate lymphoid cells, gamma/delta T cells, NKT and MAIT cells, immunometabolism, maternal-fetal immunology and more. Contains abundant full-color illustrations and tables that provide essential information at a glance. Features annual updates from the authors to the VST version, keeping you current with changes in this dynamic field from the experts. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Presents the challenges posed by the extremely complex, transboundary nature of pandemics ranging from local to global readiness, preparedness, response, and containment Introduces readers to the broad spectrum of pandemic effects: legal, military, economic, political, and social at the local, regional, and international scale Provides an unvarnished and critical view of the national and international politics of pandemic detection, monitoring, containment, and prevention

In this issue of Infectious Disease Clinics of North America, guest editor Dr. Robert P. Smith brings his considerable expertise to the topic of Lyme Disease and the Expanding Spectrum of Associated Tick-Borne Illness. With a primary focus on Lyme disease and its complications, the thorough reviews in this issue will also discuss the epidemiology, clinical presentations, diagnosis, treatment and outcomes of other infections transmitted by the black-legged tick in North America. The complexity of the public narrative of these diseases will also be addressed with an eye toward providing the clinician with a context for response. Contains 14 practice-oriented topics including early Lyme disease: erythema migrans and Its mimics; Lyme arthritis; neurologic Lyme disease: four common fallacies and three diagnostic requirements; persistent symptoms in patients with treated Lyme disease; ID specialists approach to consultation in patients referred for refractory illness attributed to tick-borne disease; and more. Provides in-depth clinical reviews on Lyme disease and the expanding spectrum of associated tick-borne illness, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This book examines how decisions made by the Conservative government during the COVID19 pandemic have increased economic inequality in the UK. Decades of austerity, asset-based welfare and financialization had already exacerbated social divisions in the UK prior to the pandemic. The political blueprint behind these measures combined Privatized Keynesianism and the Asset Economy. To explain, economists have highlighted that inequality derives from the fact that income from wealth increases at a faster rate than income from wages. The ensuing political assumption is that - in the face of pressures on public finances - promoting asset ownership is the best alternative to government-funded welfare schemes. What this meant, as the pandemic unfolded, was that when tough decisions about resource allocation needed to be made, the UK Treasury and the Bank of England found almost unlimited funds to rescue and protect asset-holders and middle-income homeowners, whilst reverting to a narrative of "misfortune" for the asset-less poor. This book assesses the political decisions taken by UK policymakers during 2020-21 and their consequences. In doing so, it challenges policymakers and the informed public to re-consider the morality of inequality, and to make alternative decisions to promote a more ecologically sustainable, caring, equal and prosperous society.

"Infection: Microbiology and Management" provides a core resource for the understanding of medical microbiology and infectious diseases. Content covers microbiological and clinical diagnosis, through to clinical management, epidemiology and the control of infectious conditions as they occur both in the hospital and community setting.

With a concise, systems-based approach, the third edition has been revised and restructured and now covers wider epidemiological and public concerns. Key feature boxes, self assessment and case studies assist learning in each chapter.

Designed to be used either as a basic learning text, or as a practical textbook in the clinical setting, "Infection: Microbiology and Management, previously" titled "Infectious Disease," will continue to appeal to students at all stages of their career, candidates for higher examinations, the general physician and surgeon, epidemiologists and experts in public health.

Widely used by students, residents, generalists, and specialists, Netter's Infectious Diseases, 2nd Edition delivers must-know information on infectious diseases in a highly illustrated, easily accessible format. Concise visual overviews of essential topics provide a convenient, trustworthy way to review the basics of a given infectious disease or issue or to share with patients or staff. Drs. Elaine Jong and Dennis Stevens cover the basics of this complex field using memorable illustrations by world-renowned artist Frank H. Netter and others, offering a time-saving, authoritative look at infectious diseases life cycles, clinical presentations, and pathophysiology. Covers major conditions and problems such as vaccine-preventable diseases, drug-resistant staph, community acquired pneumonia, surgical infections, pyelonephritis, viral hepatitis, and sexually transmitted infections-and provides updated approaches to diagnosis, treatment, prevention, and standards of care. Includes new clinical vignettes added to most chapters. Provides updated and expanded coverage of emerging infectious diseases such as multidrug resistant tuberculosis (MDR-TB), neuroangiostrongyliasis (rat lungworm disease), Ebola virus, Severe Acute Respiratory Disease (SARS), Middle East Respiratory Syndrome (MERS), Coronavirus Infectious Disease-2019 (COVID-19), and novel influenza viruses including public health concerns. Covers vector-borne diseases including malaria, yellow fever, Zika infections and congenital Zika syndrome, West Nile fever, Lyme disease, tick-borne encephalitis, and Chagas disease plus others. New chapters on travelers' diarrhea, cholera, and primary amebic meningoencephalitis debut in the section on international travel and outdoor activities. Contains memorable parasite life cycles and unforgettable parasite infection clinical vignettes. Features unparalleled illustrations by Drs. Frank H. Netter, Carlos Machado, and others, as well as radiologic images. Provides 24 printable patient education brochures in the enhanced ebook. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

In this issue of Primary Care: Clinics in Office Practice, guest editor J. Lane Wilson brings considerable expertise to the topic of office-based procedures. Provides in-depth reviews on the latest updates in office-based procedures, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Clinics of North America Clinics of North America

The 2nd edition of PANDEMIC (Clinical Press 2021) updates the history of plagues and provides extra chapters concentrating on the origin of the Covid-19 pandemic, treatment, vaccination and the effect of lockdowns. As one furloughed doctor said the first edition sorted out my mind. We are very lucky to be living in the 21st century and comparison with the many plagues of the past puts the Covid-19 pandemic in its place. The second edition continues this cathartic exercise and puts into some order the origin, the prevention and the treatment of the condition. Historical records show that people who work with viruses are often prone to accidental escapes from their laboratories like the one giving origin to COVID-19. The lessons of history are heavily in favour of the lab-leak theory compared with the now-discredited theory of zoonotic origin. Interspersed with the serious history are true personal anecdotes and a few ridiculous cartoons. The author points out: Laughing at the things we fear is one of the best ways of putting those fears into perspective.

Recent years have seen an explosion in new kinds of data on infectious diseases, including data on social contacts, whole genome sequences of pathogens, biomarkers for susceptibility to infection, serological panel data, and surveillance data. The Handbook of Infectious Disease Data Analysis provides an overview of many key statistical methods that have been developed in response to such new data streams and the associated ability to address key scientific and epidemiological questions. A unique feature of the Handbook is the wide range of topics covered. Key features Contributors include many leading researchers in the field Divided into four main sections: Basic concepts, Analysis of Outbreak Data, Analysis of Seroprevalence Data, Analysis of Surveillance Data Numerous case studies and examples throughout Provides both introductory material and key reference material

The first edition of Infection Prevention reviewed evolving areas in infection prevention on topics including contact precautions, technology implementation, specific infections, and care in various settings. It summarized the current data on infection prevention, presents controversies on the various topics, and includes recommendations for patient safety. Addressing hot topics such as MRSA, C. difficile vaccination, mandatory flu vaccines, and CLABSI, this is the only text to include prevention and control overviews across a range of infection issues. Written by experts in the field, this successor edition will update current chapters on the most cutting-edge models of care on emerging and evolving topics in infectious diseases. It will also include new material and chapters on high-level disinfection, diagnostic test stewardship, unique pathogens units, outpatient antibiotic stewardship, outpatient antibiotic therapy, as well as a chapter on infection prevention metrics: how much can we prevent healthcare associated infections and how hard should we try. The second edition of Infection Prevention: New Perspectives and Controversies is a valuable resource for infection prevention professionals, healthcare quality and safety professionals, caring for patients in in- and outpatient settings.

A sweeping germ's-eye view of history from human origins to global pandemics Plagues upon the Earth is a monumental history of humans and their germs. Weaving together a grand narrative of global history with insights from cutting-edge genetics, Kyle Harper explains why humanity's uniquely dangerous disease pool is rooted deep in our evolutionary past, and why its growth is accelerated by technological progress. He shows that the story of disease is entangled with the history of slavery, colonialism, and capitalism, and reveals the enduring effects of historical plagues in patterns of wealth, health, power, and inequality. He also tells the story of humanity's escape from infectious disease-a triumph that makes life as we know it possible, yet destabilizes the environment and fosters new diseases. Panoramic in scope, Plagues upon the Earth traces the role of disease in the transition to farming, the spread of cities, the advance of transportation, and the stupendous increase in human population. Harper offers a new interpretation of humanity's path to control over infectious disease-one where rising evolutionary threats constantly push back against human progress, and where the devastating effects of modernization contribute to the great divergence between societies. The book reminds us that human health is globally interdependent-and inseparable from the well-being of the planet itself. Putting the COVID-19 pandemic in perspective, Plagues upon the Earth tells the story of how we got here as a species, and it may help us decide where we want to go.

As human society continues to develop, we have increased the risk of large-scale disasters. From health care to infrastructure to national security, systems designed to keep us safe have also heightened the potential for catastrophe. The constant pressure of climate change, geopolitical conflict, and our tendency to ignore what is hard to grasp exacerbates potential dangers. How can we prepare for and prevent the twenty-first-century disasters on the horizon? Rethinking Readiness offers an expert introduction to human-made threats and vulnerabilities, with a focus on opportunities to reimagine how we approach disaster preparedness. Jeff Schlegelmilch identifies and explores the most critical threats facing the world today, detailing the dangers of pandemics, climate change, infrastructure collapse, cyberattacks, and nuclear conflict. Drawing on the latest research from leading experts, he provides an accessible overview of the causes and potential effects of these looming megadisasters. The book highlights the potential for building resilient, adaptable, and sustainable systems so that we can be better prepared to respond to and recover from future crises. Thoroughly grounded in scientific and policy expertise, Rethinking Readiness is an essential guide to this century's biggest challenges in disaster management.

Dr. Kaye and Dr. Dhor have assembled top experts to write about clinical management of infections in Part II of their two issues devoted to Infection Prevention and Control in Healthcare. Articles in this issue are devoted to: CLABSI; UTI; Tuberculosis; Ventilator-Assisted Pneumonia; Surgical Site Infection; MRSA; VRE; Gram-Negative Bacilli; Fungal Infections; C. Difficile, and Emerging Infections including Ebola. Infectious Disease physicians and anyone in the hospital setting will find this issue very useful, as state-of-the-art clinical reviews provide clinical management on these common and emerging infections.

In this issue of Primary Care: Clinics in Office Practice, guest editors Luz M. Fernandez and Jonathan A. Becker bring their considerable expertise to the topic of Common Pediatric Issues. Provides in-depth, clinical reviews on Common Pediatric Issues, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the second edition of a well-received book that provides a comprehensive update on the pathology of the disease, as well as on the concept of parasitic drug resistance, its molecular basis, consequences and possible treatments. A valuable resource for scientists both from academia and industry involved in biomedical research and drug design, the book provides the knowledge needed to understand leishmaniasis and to contibute to combatting this disease worldwide.

This book brings together expert opinions from scientists to consider the evidence for climate change and its impacts on ticks and tick-borne infections. It considers what is meant by 'climate change', how effective climate models are in relation to ecosystems, and provides predictions for changes in climate at global, regional and local scales relevant for ticks and tick-borne infections. It examines changes to tick distribution and the evidence that climate change is responsible. The effect of climate on the physiology and behaviour of ticks is stressed, including potentially critical impacts on the tick microbiome. Given that the notoriety of ticks derives from pathogens they transmit, the book considers whether changes in climate affect vector capacity. Ticks transmit a remarkable range of micro- and macro-parasites many of which are pathogens of humans and domesticated animals. The intimacy between a tick-borne agent and a tick vector means that any impacts of climate on a tick vector will impact tick-borne pathogens. Most obviously, such impacts will be apparent as changes in disease incidence and prevalence. The evidence that climate change is affecting diseases caused by tick-borne pathogens is considered, along with the potential to make robust predictions of future events. This book contains: Expert opinions and predictions. Global coverage of trends in ticks and disease. In-depth examination of climate change and tick distribution links. This book is suitable for researchers and students studying zoology, biological sciences, medical entomology, animal health, veterinary medicine, epidemiology, parasitology, and climate change impacts; and for those concerned with public health planning or livestock management where ticks and tick-borne pathogens pose a threat.

From the latest vaccination evidence, recommendations, and protocols . . . to new vaccine development and the use of vaccines in reducing disease, Plotkin's Vaccines, 8th Edition, covers every aspect of vaccination. Now completely revised and updated from cover to cover, this award-winning text continues to provide reliable information from global authorities, offering a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. Contains all-new chapters on COVID-19, vaccine hesitancy, and non-specific effects of vaccines, as well as significantly revised content on new vaccine technologies such as mRNA vaccines, emerging vaccines, and technologies to improve immunization. Presents exciting new data on evolution of adjuvants across the centuries, dengue vaccines, human papillomavirus vaccines, respiratory syncytial virus vaccines, tuberculosis vaccines, and zoster vaccines. Provides up-to-date, authoritative information on vaccine production, available preparations, efficacy and safety, and recommendations for vaccine use, with rationales and data on the impact of vaccination programs on morbidity and mortality. Provides complete coverage of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues. Keeps you up to date with information on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. Covers vaccine-preventable diseases, vaccine science, and licensed vaccine products, as well as product technologies and global regulatory and public health issues. Analyzes the cost-benefit and cost-effectiveness of different vaccine options. Helps you clearly visualize concepts and objective data through an abundance of tables and figures. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The pandemic caused by SARS-CoV-2 has changed how we live our lives, and most likely will do so for years to come. While not exclusively about SARS-CoV-2, The Prepper's Guide to Surviving Pandemics, Bioterrorism, and Infectious Disease covers the subject thoroughly and also delves into the massive controversy concerning herd immunity, which vaccines are the most likely to work, the issue of second wave or resurgence caused by school re-openings and other activities, changes in public policy, and numerous other topics.

Written by world-renowned experts, this book addresses immunological and molecular methodologies of diagnosis as well as clinical aspects of diseases. It book discusses DNA and RNA amplification methods, explains ELISA approaches, and introduces rapid diagnosis techniques, biosensors, and flow cytometry. The book examines bacterial and parasitic infections, including M. tuberculosis, Borrelia burgdorferi, Streptococcus pyogenes, chlamydia and schistosomes, and describe viral infections such as hantaviruses, hepatitis C., cytomegalovirus, herpes virus, and HIV. It also covers syndromes with infections origins, including prions, chronic fatigue syndrome, and superantigens, and much more.

An updated edition of the essential guide to dealing with common respiratory illness, featuring a new chapter offering practical strategies on how to prevent, treat, and recover from Covid-19. From cold and flu to pneumonia and bronchitis; from tonsillitis and sinusitis to SARS, eminent pulmonologist Neil Schachter, M.D., explains how to treat and prevent common respiratory illnesses and protect yourself from Covid-19. The Good Doctor's Guide to Colds and Flu shows how to avoid illness, boost immunity, and combat congestion, fever, and discomfort when cold, flu, and other infections strike. Dr. Schachter provides the latest and most effective information and advice to help you protect your health including: Six prevention and treatment plans for the six most common respiratory infections: colds, influenza, sinusitis, bronchitis, tonsillitis, and pneumonia The four stages of a cold, and one of the best ways to avoid catching one Conflicting research on well-known cold remedies such as Vitamin C, Zinc, and Echinacea The four major types of pneumonias, and the prevention technique that can eliminate more than 80 organisms that cause it Why humming five seconds a day can reduce risk of sinus problems The surprising reason why women catch more colds The five best ways to conquer a cough Three symptoms that signal it's time to call a doctor And much more