In the past two decades, several pandemics have ravaged the globe, giving us several lessons on infectious disease epidemiology, the importance of initial detection and characterization of outbreak viruses, the importance of viral epidemic prevention steps, and the importance of modern vaccines. Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment summarizes the improvements in the 21st century to overcome / prevent / treat global pandemic with future prospective. Divided into 9 chapters, the book begins with an in-depth introduction to the lessons learned from the first pandemic of the 21st century. It describes the history, present and future in terms of detection, prevention and treatment. Followed by chapters on the outbreak, treatment strategies and clinical management of several infectious diseases like MERS, SARD and COVID 19, Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment, presents chapters on immunotherapies and vaccine technologies to combat pandemic outbreak and challenges. The book finishes with a chapter on the current knowledge and technology to control pandemic outbreaks. All are presented in a practical short format, making this volume a valuable resource for very broad academic audience.

Plague and the City uncovers discourses of plague and anti-plague measures in the city during the medieval, early modern and modern periods, and explores the connection between plague and urban environments including attempts by professional bodies to prevent or limit the outbreak of epidemic disease. Bringing together leading scholars of plague working across different historical periods, this book provides an inter-disciplinary study of plague in the city across time and space. The chapters cover a wide range of periods, geographical locations and disciplinary approaches but all seek to answer significant questions, including whether common motives can be identified, and how far knowledge about plague was based on an understanding of the urban space. It also examines how maps and photographs contribute to understanding plague in the city through exploring the ways in which the relationship between plague and the urban environment has been visualised, from the poisoned darts of plague winging their way towards their victims in the votive pictures from the Renaissance, to the mapping of the spread of disease in late nineteenth-century Bombay and photographing Honolulu's great plague fire in 1900. Containing a series of studies that illuminate plague's urban connection as a key social and political concern throughout history, Plague and the City is ideal for students of early modern history, and of the early modern city and plague more specifically.

Plague and the City uncovers discourses of plague and anti-plague measures in the city during the medieval, early modern and modern periods, and explores the connection between plague and urban environments including attempts by professional bodies to prevent or limit the outbreak of epidemic disease. Bringing together leading scholars of plague working across different historical periods, this book provides an inter-disciplinary study of plague in the city across time and space. The chapters cover a wide range of periods, geographical locations and disciplinary approaches but all seek to answer significant questions, including whether common motives can be identified, and how far knowledge about plague was based on an understanding of the urban space. It also examines how maps and photographs contribute to understanding plague in the city through exploring the ways in which the relationship between plague and the urban environment has been visualised, from the poisoned darts of plague winging their way towards their victims in the votive pictures from the Renaissance, to the mapping of the spread of disease in late nineteenth-century Bombay and photographing Honolulu's great plague fire in 1900. Containing a series of studies that illuminate plague's urban connection as a key social and political concern throughout history, Plague and the City is ideal for students of early modern history, and of the early modern city and plague more specifically.

When the SARS virus broke out in China in January 2003, Karl Taro Greenfeld was the editor of Time Asia in Hong Kong, just a few miles from the epicenter of the outbreak. After vague, initial reports of terrified Chinese boiling vinegar to "purify" the air, Greenfeld and his staff soon found themselves immersed in the story of a lifetime.

Deftly tracking a mysterious viral killer from the bedside of one of the first victims to China's overwhelmed hospital wards--from cutting-edge labs where researchers struggle to identify the virus to the war rooms at the World Health Organization headquarters in Geneva--"China Syndrome" takes readers on a gripping ride that blows through the Chinese government's effort to cover up the disease . . . and sounds a clarion call warning of a catastrophe to come: a great viral storm potentially more deadly than any respiratory disease since the influenza of 1918.

Zika Virus Impact, Diagnosis, Control, and Models: Volume Two: The Neuroscience of Zika examines diagnosis, vaccines, and potential therapy methods for Zika virus syndrome. The book also details the neuroscience of Guillain-Barre syndrome, its effects and neuromuscular rehabilitation. It is designed to help readers better understand detection, therapies for Zika virus, preventative vaccines, diagnosis and associated microcephaly. Chapters on models enable further research and understanding. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

Zika Virus Biology, Transmission, and Pathways: The Neuroscience of Zika, Volume One provides a detailed introduction to the molecular biology of the Zika virus and its features, transmission, and impact on neurological systems. Designed to better readers' understanding of the Zika virus, this volume features chapters on the immune response, molecular mechanisms, and other areas to better understand underlying pathways. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

The book starts with dissecting mechanisms underlying viral immune evasion via exploiting the host complement system by vaccinia virus, and by modulating the type 1 interferon response by RNA viruses. Yet another chapter looks into how viroporins expressed by different families of viruses causing influenza A virus, SARS, hepatitis C and HIV interact with several cellular pathways. Understanding of these mechanisms can aid the development of novel potential anti viral targets. The chapter on tuberculosis discusses the emerging importance of the innate immune mechanisms against Mycobacterium tuberculosis infection and latency. This book has a strong focus on fungal pathogenesis and immunity, starting with virulence and host factors that attain great importance in candidiasis and associated escape tricks ofseriously opportunistic fungi. Two chapters on Aspergillus fumigatus elaborate on the pathogenic mechanisms: first discussing A. fumigatus airway epithelium interaction, followed by fungal and host factors that are paramount in the development of allergic and invasive aspergillosis. In the subsequent chapter, there is a general discussion on the innate and adaptive immune responses against primary and opportunistic fungal pathogens."

Features modern research and methodology on the spread of infectious diseases and showcases a broad range of multi-disciplinary and state-of-the-art techniques on geo-simulation, geo-visualization, remote sensing, metapopulation modeling, cloud computing, and pattern analysis Given the ongoing risk of infectious diseases worldwide, it is crucial to develop appropriate analysis methods, models, and tools to assess and predict the spread of disease and evaluate the risk. Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases features mathematical and spatial modeling approaches that integrate applications from various fields such as geo-computation and simulation, spatial analytics, mathematics, statistics, epidemiology, and health policy. In addition, the book captures the latest advances in the use of geographic information system (GIS), global positioning system (GPS), and other location-based technologies in the spatial and temporal study of infectious diseases. Highlighting the current practices and methodology via various infectious disease studies, Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases features: * Approaches to better use infectious disease data collected from various sources for analysis and modeling purposes * Examples of disease spreading dynamics, including West Nile virus, bird flu, Lyme disease, pandemic influenza (H1N1), and schistosomiasis * Modern techniques such as Smartphone use in spatio-temporal usage data, cloud computing-enabled cluster detection, and communicable disease geo-simulation based on human mobility * An overview of different mathematical, statistical, spatial modeling, and geo-simulation techniques Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases is an excellent resource for researchers and scientists who use, manage, or analyze infectious disease data, need to learn various traditional and advanced analytical methods and modeling techniques, and become aware of different issues and challenges related to infectious disease modeling and simulation. The book is also a useful textbook and/or supplement for upper-undergraduate and graduate-level courses in bioinformatics, biostatistics, public health and policy, and epidemiology.

Fungal Infection: Diagnosis and Management, 4th Edition is a concise and up-to-date guide to the clinical manifestations, laboratory diagnosis and management of superficial, subcutaneous and systemic fungal infections. This highly acclaimed book has been extensively revised and updated throughout to ensure all drug and dosage recommendations are accurate and in agreement with current guidelines. A new chapter on infections caused by Pneumocystis jirovecii has been added. The book has been designed to enable rapid information retrieval and to help clinicians make informed decisions about diagnosis and patient management. Each chapter concludes with a list of recent key publications which have been carefully selected to facilitate efficient access to further information on specific aspects of fungal infections. Clinical microbiologists, infectious disease specialists, as well as dermatologists, hematologists and oncologists, can depend on this contemporary text for authoritative information and the background necessary to understand fungal infections.

This textbook, which is the first volume in the series Microbial Zoonoses, provides a comprehensive overview of the diagnosis, treatment and control of zoonotic parasitic diseases. The book is divided into two sections; the first section discusses the classification of parasitic zoonoses and includes general information on the diagnosis, treatment, epidemiology, prevention, and control of parasitic zoonoses. It also describes the biological features of these organisms, host-parasite interactions, and the disease spectrum, as well as the importance of public health control measures, such as surveillance, and prophylactic measures in controlling these diseases.The second section explores the important zoonotic diseases caused by ectoparasites, protozoan and helminths parasites. It also reviews the life cycle, pathogenesis, pathology, immunology and clinical manifestations, modern diagnostic methods, treatment regimen, prevention, control, and epidemiology of these parasites.Cutting across the disciplines, this book serves as a guide to postgraduate students, faculty members, public health experts, and medical administrators who are interested in the management of these parasitic zoonotic infections.

Pocket Guide to Bacterial Infections provides information pertinent to the behaviour of bacterial cells during their interactions with different cell types of multiple host systems. This book will present the role of various bacterial pathogens affecting the host system. The book is to be organized flexibly so that chapters and topics are arranged with continuity from the former chapters. Each chapter has been made as self-contained as possible to promote this flexibility. This book will discuss each of the virulence properties of the bacteria with reference to their interacting hosts in a larger perspective. Kwey selling features: Summarizes the role various bacterial pahtogens affect the host system Reviews recent advances for combating different types of bacterial infections that infect different body parts Designed as an effective teaching and research tool providing up to date information on bacterial infections Defines important terms Written in a readable and direct writing style

The COVID-9 pandemic has generated human suffering and economic devastation across the world - but these reflect not just the impact of the disease but the policy failures of governments. Further, the trajectory of the disease and the human and economic outcomes has varied greatly, again because of how governments have responded and the institutional context. This volume brings together analyses of the public policy responses from many different countries, to evaluate what has worked and what hasn't, what has been done and what could have been done - and the potential directions for the future.

Avian influenza is a viral asteroid on a collision course with humanity. In 1918 a pandemic strain of influenza killed at least 40 million people in three months. Now, leading researchers believe, another world catastrophe is imminent. A virus of astonishing lethality, known as H5N1, has become entrenched in the poultry and wild bird populations of East Asia. It kills two out of three people it infects. The World Health Organisation warns that it is on the verge of mutating into a super-contagious pandemic form that could visit several billion homes within two years. In this urgent and extraordinarily frightening book, Mike Davis reconstructs the scientific and political history of a viral apocalypse-in-the-making, exposing the central roles of agribusiness and the fast-food industries, abetted by corrupt governments, in creating the ecological conditions for the emergence of this new plague. He also details the scandalous failure of the Bush administration, obsessed with hypothetical bio-terrorism, to safeguard Americans from the greatest biological threat since HIV/AIDS. sacrificed the poor in Africa and South Asia, for whom, in the almost certain event of a pandemic, there will be no anti-virals or vaccines.

Whether you need to manage a post-transplant infection or reduce the possibility of infection, you will find effective guidance in this handbook. The work of the American Society of Transplantation Infectious Diseases Community of Practice, this reference exclusively uses tables and flowcharts to speed up decision making. This distinguished group of investigators and teachers provide point of care information on optimum management of infection in adult and pediatric organ and stem cell transplant patients. The unique tables and flowcharts are devised by the authors, backed up with extensive references, making the book a fully researched yet easy to use guide. The fast growing specialty of transplantation will be well served by this book as increasing numbers of successful procedures mean transplant teams have to be ever more alert to the possibility of and need for action in the event of ensuing infection.

As more original molecular protocols and subsequent modifications are described in the literature, it has become difficult for those not directly involved in the development of these protocols to know which are most appropriate to adopt for accurate identification of bacterial pathogens. Molecular Detection of Human Bacterial Pathogens addresses this issue, with international scientists in respective bacterial pathogen research and diagnosis providing expert summaries on current diagnostic approaches for major human bacterial pathogens. Each chapter consists of a brief review on the classification, epidemiology, clinical features, and diagnosis of an important pathogenic bacterial genus, an outline of clinical sample collection and preparation procedures, a selection of representative stepwise molecular protocols, and a discussion on further research requirements relating to improved diagnosis. This book represents a reliable and convenient reference on molecular detection and identification of major human bacterial pathogens; an indispensable tool for upcoming and experienced medical, veterinary, and industrial laboratory scientists engaged in bacterial characterization; and an essential textbook for undergraduate and graduate students in microbiology.

This volume, written in a readable and enticing style, is based on a simple premise, which was to have several exceptional ethnographers write about their experiences in an evocative way in real time during the COVID-19 pandemic. Rather than an edited volume with dedicated chapters, this book thus offers a new format wherein authors write several, distinct dispatches, each short and compact, allowing each writer's perspectives and stories to grow, in tandem with the pandemic itself, over the course of the book. Leaving behind the trope of the lonely anthropologist, these authors come together to form a collective of ethnographers to ask important questions, such as: What does it mean to live and write amid an unfolding and unstoppable global health and economic crisis? What are the intensities of the everyday? How do the isolated find connection in the face of catastrophe? Such first-person reflections touch on a plurality of themes brought on by the pandemic, forces and dynamics of pressing concern to many, such as contagion, safety, health inequalities, societal injustices, loss and separation, displacement, phantasmal imaginings and possibilities, the uncertain arts of calculating risk and protection, limits on movement and travel, and the biopolitical operations of sovereign powers. The various writings-spun from diverse situations and global locations-proceed within a temporal flow, starting in March 2020, with the first alerts and cases of viral infection, and then move on to various currents of caution, concern, infection, despair, hope, and connection that have unfolded since those early days. The writings then move into 2021, with events and moods associated with the global distribution of potentially effective vaccines and the promise and hope these immunizations bring. The written record of these multiform dispatches involves traces of a series of lives, as the authors of those lives tried to make do, and write, in trying times. A timely ethnography of an event that has changed all our lives, this book is critical reading for students and researchers of medical anthropology, sociocultural anthropology, contemporary anthropological theory, and ethnographic writing.

Explores the scientific and social factors that continue to influence the public's lingering uncertainty over how disease can-and cannot-be spread. Late in the summer of 1880, a wave of odors enveloped large portions of Paris. As the stench lingered, outraged residents feared that the foul air would breed an epidemic. Fifteen years later-when the City of Light was in the grips of another Great Stink-the public conversation about health and disease had changed dramatically. Parisians held their noses and protested, but this time few feared that the odors would spread disease. Historian David S. Barnes examines the birth of a new microbe-centered science of public health during the 1880s and 1890s, when the germ theory of disease burst into public consciousness. Tracing a series of developments in French science, medicine, politics, and culture, Barnes reveals how the science and practice of public health changed during the heyday of the Bacteriological Revolution. Despite its many innovations, however, the new science of germs did not entirely sweep away the older "sanitarian" view of public health. The longstanding conviction that disease could be traced to filthy people, places, and substances remained strong, even as it was translated into the language of bacteriology. Ultimately, the attitudes of physicians and the French public were shaped by political struggles between republicans and the clergy, by aggressive efforts to educate and "civilize" the peasantry, and by long-term shifts in the public's ability to tolerate the odor of bodily substances.

This book adopts collaborative autoethnography as its methodology, and presents the collective witnessing of experiences of the COVID-19 pandemic within the higher education sector. Through the presentation of staff and student experiences and what was learnt from them, the authors examine the global phenomenon that is the COVID-19 pandemic through the purposeful exploration of their own experiences. This book presents an overall argument about the state of higher education in the middle of the pandemic and highlights academic issues and region-specific challenges. The reflections presented in this book offer insights for other staff and students, as well as academic policy-makers, regarding the pandemic experiences of those within academia. It also offers practical suggestions as to how we as a global community can move forward post-pandemic.

This issue of Clinics in Chest Medicine, edited by Dr. Charles L. Daley and Dr. David Lewinsohn, focuses on Tuberculosis. Topics include: Epidemiology of Tuberculosis (TB) in the United States; Immunology of Tuberculosis; Tuberculosis and Biologics; Laboratory Diagnosis of Tuberculosis; Supranational Tuberculosis Reference Laboratories (a global approach); Treatment of Drug Susceptible Tuberculosis; Treatment of Drug-Resistant Tuberculosis; New Drugs for the Treatment of Tuberculosis; Diagnosis of Latent Tuberculosis: the Role of Interferon Gamma Release; Treatment of Latent Tuberculosis; Management of Children with Tuberculosis; Tuberculosis and HIV; The Future of Vaccines for Tuberculosis; and Preventing Transmission of M. Tuberculosis.

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. * Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application * Includes evaluation of vaccine efficacy and safety * Details clinical trial design, including regulatory requirements * Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

Continued geographic expansion of dengue viruses and their mosquito vectors has seen the magnitude and frequency of epidemic dengue/dengue hemorrhagic fever (DF/DHF) increase dramatically. Recent exciting research on dengue has resulted in major advances in our understanding of all aspects of the biology of these viruses, and this updated second edition brings together leading research and clinical scientists to review dengue virus biology, epidemiology, entomology, therapeutics, vaccinology and clinical management.

Now in its sixth edition, Infectious Diseases in Obstetrics and Gynecology remains the only book to comprehensively cover infectious diseases in both obstetrics and general gynecology. Distilling complex clinical problems into an easy to use format, this text is divided in four unique sections, and some of these topics include:

Filled with highly instructional visual images, An Atlas of the Clinical Microbiology of Infectious Diseases, Volume 1: Bacterial Agents contains typical and atypical presentations and identifying characteristics of microorganisms, including newly described microbial agents, covering the breadth of clinical microbiology. The book presents more than 425 color photomicrographs harvested over the author's 40-year career augmented by up-to-date text describing each microbial entity included and offering insightful comments on their clinical significance.

Effectively Assess Intervention Options for Controlling Infectious Diseases Our experiences with the human immunodeficiency virus (HIV), severe acute respiratory syndrome (SARS), and Ebola virus disease (EVD) remind us of the continuing need to be vigilant against the emergence of new infectious diseases. Mathematical modeling is increasingly used in the management of infectious disease control as a way to assess interventions relatively quickly, cheaply, and safely. Modeling to Inform Infectious Disease Control shows readers how to take advantage of these models when developing strategies to mitigate infectious disease transmission. The book presents a way of modeling as well as modeling results that help to guide the effective management of infectious disease transmission and outbreak response. It discusses the requirements for preventing epidemics and ways to quantify the impact of preventative public health interventions on the size and dynamics of an epidemic. The book also illustrates how data are used to inform model choice. Accessible to readers with diverse backgrounds, this book explains how to gain insight into the management of infectious diseases through statistical modeling. With end-of-chapter exercises and glossaries of infectious disease terminology and notation, the text is suitable for a graduate-level public health course. Supplementary technical material is provided at the end of each chapter for readers with a stronger background in mathematics and an interest in the art of modeling. In addition, bibliographic notes point readers to literature in which extensions and more general results can be found.