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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General

Neural-Immune Interactions in Brain Function and Alcohol Related Disorders (Hardcover, 2013 ed.): Changhai Cui, Lindsey... Neural-Immune Interactions in Brain Function and Alcohol Related Disorders (Hardcover, 2013 ed.)
Changhai Cui, Lindsey Grandison, Antonio Noronha
R5,885 Discovery Miles 58 850 Ships in 10 - 15 working days

Recent studies have provided clear evidence on the role of neural-immune interactions in normal brain function and neuropathological conditions. Neuroimmune factors, which play an essential role in neuroinflammatory response, have been implicated in the regulation of neuronal function and plasticity. Thus, neural-immune interactions provide a new frame work for understanding the role of the neuroimmune system in normal brain function, neurodevelopment, and a variety of neurological disorders. These advances have a far reaching impact on many areas of neuroscience, including alcohol research. Studies using human alcoholic brains, gene knockout mice, and gene expression profiling have established a clear link between alcoholism and an altered neuroimmune profile. This book integrates emerging knowledge on neural-immune interactions with key discoveries in alcohol research and provides a comprehensive overview of neural-immune interactions in brain function and behavior associated with alcohol use disorders. While "Neural Immune Interaction in Brain Function and Alcohol Related Disorders" focuses on neural-immune interactions in areas directly related to alcohol use disorders, it is not intended to be all inclusive. Several areas, including sleep disorders, pain, and cholinergic anti-inflammatory pathways, are not covered as independent chapters but briefly mentioned in the text. The close relevance of these topics to neural-immune interactions and alcohol use disorders warrants future discussion and more research efforts."

Cell Activation and Apoptosis in HIV Infection - Implications for Pathogenesis and Therapy (Paperback, Softcover reprint of the... Cell Activation and Apoptosis in HIV Infection - Implications for Pathogenesis and Therapy (Paperback, Softcover reprint of the original 1st ed. 1995)
Jean-Marie Andrieu, Wei Lu
R1,567 Discovery Miles 15 670 Ships in 10 - 15 working days

In the past decade, the global efforts in the control of HIV disease were basically concentrated on the search for anti-retroviral agents. So far, anti-HIV therapies have been shown to be disappointing because of rapid development of drug-resistant mutant variants. Despite this drawback in the therapeutic fight against HIV infection, antiviral research should be actively pursued. However, failure of antiviral therapy indicates that other avenues of research should be rapidly explored with the same energy. In this setting, striking advances have been recently made in the dissection and understanding of the viro-immunological processes governing the progressive destruction of lymphoid organs associated with AIDS develop ment, and HIV-induced activation and apoptosis have been identified as key phenomena of the immune system destruction. This book assembles the most recent advances on basic and clinical aspects ofT-cell activationiapoptosis in HIV infection and their implications for immunotherapy. These data were presented at an international symposium held on July 11-12, 1994, in Paris. The book is partitioned into 21 chapters covering four comprehensive fields: 1) T-celllmacrophage activation and HIV infection; 2) Apoptosis and viropathogenesis of HI V disease; 3) Apop tosis and immunopathogenesis ofHIV disease; 4) Mediators ofT-cell activationiapoptosis and therapeutic applications. We hope that this book will assist the readers in understanding recent advances in the viro-immunopathogenesis of HI V disease as well as the rationales for potential immune cell-targeted therapeutic interventions.

Glycobiology and Medicine (Paperback, Softcover reprint of the original 1st ed. 2003): John S. Axford Glycobiology and Medicine (Paperback, Softcover reprint of the original 1st ed. 2003)
John S. Axford
R1,584 Discovery Miles 15 840 Ships in 10 - 15 working days

Over the past decade significant advances in technology have opened up the field of glycobiology. In particular, improved methods for carbohydrate analysis have led to important biochemical observations demonstrating that sugars play crucial roles in human physiology. It is clear that many diseases are associated with characteristic changes in glycosylation and furthermore, the possibility of modulating glycan processing to treat disease is beginning to be realised. This volume summarises some of the important recent developments in "glycobiology and medicine. " We highlighted some of the numerous areas in which there are glycosylation dependant pathological mechanisms causing common diseases. The next decade will undoubtedly see novel diagnostic and therapeutic techniques originating from these observations. This will significantly enhance our ability to combat infection and diseases such as bacterial and viral infections, some cancers, glycolipid storage disorders, systemic autoimmune disease and disorders that involve cytokine related inflammatory mechanisms. These topics were discussed at the 6th Jenner Glycobiology and Medicine meeting. This meeting received a European Commission Education grant (No. HPCF-2002-00250). CONTENTS Glycosylation Dependent Bacterial Infections 1. A Sweet Coating-How Bacteria Deal with Sugars ...3 Anthony P. Corfield, Rebecca Wiggins, Cathryn Edwards, Neil Myerscough, Bryan F. Warren, Peter Soothill, Michael R. Millar, and Patrick Horner 2. The Glycosylation of Airway Mucins in Cystic Fibrosis and Its Relationship with Lung Infection by Pseudomonas aeruginosa ...17 . Philippe Roussel and Genevieve Lamblin 3. Structural Basis for Bacterial Adhesion in the Urinary Tract...33 . . Jenny Berglund and Stefan D.

Mechanisms and Mediators of Neuropathic Pain (Paperback, Softcover reprint of the original 1st ed. 2002): Annika B. Malmberg,... Mechanisms and Mediators of Neuropathic Pain (Paperback, Softcover reprint of the original 1st ed. 2002)
Annika B. Malmberg, Sandra R. Chaplan
R6,516 Discovery Miles 65 160 Ships in 10 - 15 working days

Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury initiates a cascade of events resulting in altered neurochemistry and molecular biology of the peripheral neurons, the dorsal root ganglion cell, and changes in neurotransmitter and receptor expression in the dorsal horn of the spinal cord. Moreover, nerve injury produces anatomical changes with functional consequences.
This volume summarises the current understanding of the pathophysiological processes in the peripheral and central nervous system that contribute to the neuropathic pain. It provides a timely review of neuropathic pain mechanisms, written by experts in the field.

Immunobiology of Organ Transplantation (Paperback, Softcover reprint of the original 1st ed. 2004): David S. Wilkes, William J.... Immunobiology of Organ Transplantation (Paperback, Softcover reprint of the original 1st ed. 2004)
David S. Wilkes, William J. Burlingham
R11,788 Discovery Miles 117 880 Ships in 10 - 15 working days

Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels. The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.

Pseudomonas aeruginosa as an Opportunistic Pathogen (Paperback, Softcover reprint of the original 1st ed. 1993): Mario Campa,... Pseudomonas aeruginosa as an Opportunistic Pathogen (Paperback, Softcover reprint of the original 1st ed. 1993)
Mario Campa, Mauro Bendinelli, Herman Friedman
R1,598 Discovery Miles 15 980 Ships in 10 - 15 working days

Assembling the latest research by an international group of contributors, this volume covers the epidemiology, pathogenesis, clinical features, and control measures of this elusive microorganism. It will provide a deeper understanding of the pathogen to physicians and surgeons caring for patients infected, or at risk of becoming infected, with Pseudomonas Aeruginosa.

Heat Shock Proteins and Inflammation (Paperback, Softcover reprint of the original 1st ed. 2003): Willem Van Eden Heat Shock Proteins and Inflammation (Paperback, Softcover reprint of the original 1st ed. 2003)
Willem Van Eden
R4,485 Discovery Miles 44 850 Ships in 10 - 15 working days

Heat shock proteins (HSP) have received ample interest by immunologists over recent years. Initially they were found to be dominantly immunogenic microbial antigens. The connection with inflammation was established when it was uncovered that T cells specific for these antigens have a crucial role in the induction and regulation of experimental arthritis. Since then, the raised presence of immunity to HSPs in virtually all conditions of inflammation, including autoimmune diseases, transplant rejection and atherosclerosis, has emphasised the critical significance of immunity to HSPs in inflammatory diseases.

Disease-modifying Therapy in Vasculitides (Paperback, Softcover reprint of the original 1st ed. 2001): Cees G. M. Kallenberg,... Disease-modifying Therapy in Vasculitides (Paperback, Softcover reprint of the original 1st ed. 2001)
Cees G. M. Kallenberg, Jan W. Cohen Tervaert
R4,461 Discovery Miles 44 610 Ships in 10 - 15 working days

Especially the past two decades have seen renewed interest in the vasculitides. In this volume an international expert group presents the current state of knowledge and concentrates on principles of immune modulating therapy. Drawing from their work in rheumatology, nephrology, internal medicine, connective tissue disease and clinical immunology, they present new concepts in classificiation, diagnosis and pathophysiology of the vasculitides. Evidence from experimental and clinical trials is reviewed, as well as the outlook for further research.

Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment (Paperback, Softcover reprint of the... Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment (Paperback, Softcover reprint of the original 1st ed. 1994)
Roberto L. Ceriani
R1,559 Discovery Miles 15 590 Ships in 10 - 15 working days

Today, advances in the area of immunology and breast cancer are made at an increasing rate, yielding an amount of information that can become unwieldy. The opportunity for scientists in this area of research to gather together to exchange results and working hypotheses represents, in my belief, a very attractive proposition. With this in mind, these workshops have been convened with two year intervals for the last ten years. In each of them, selected topics have been highlighted. The present workshop underscores the large advancements made in the molecular biology of both breast cancer associated antigens and their corresponding antibodies. Understanding the genetic information for the expression of these antigens has been recently advanced leading to preparation of molecularly engineered reagents for use in vaccination, serum assays, and immunizations for novel antibody production. In the anti-breast cancer antibody field the availability of molecular engineering approaches to humanize murine antibodies has induced intense interest in the creation of less immunogenic antibody forms that are now available for clinical testing. Clinical studies using anti-breast murine antibody continue to be carried out and are presented at this meeting establishing a base line for safety and efficaciousness in imaging and immunotherapy that it is hoped will be superseded by the humanized forms. Basic immunology and immunochemistry studies in breast cancer are also included in this workshop that demonstrate the fast pace at which this research is advancing in many laboratories worldwide.

Molecular Biology of Acute Lung Injury (Paperback, Softcover reprint of the original 1st ed. 2001): Hector R. Wong, Thomas... Molecular Biology of Acute Lung Injury (Paperback, Softcover reprint of the original 1st ed. 2001)
Hector R. Wong, Thomas Shanley
R4,502 Discovery Miles 45 020 Ships in 10 - 15 working days

Acute lung injury (ALI) impacts patient care in every ICU in the world. Our collective understanding of this condition has grown immensely over the past decade but morbidity and mortality remain unacceptably high. To enhance the understanding of clinicians and researchers, this book addresses the pathophysiology of acute lung injury from a molecular and cellular standpoint; includes animal models of acute lung injury and points to potential therapeutic advances based on scientific findings. It is a concise compendium of the multiple pathways, mechanisms and molecules involved in the pathophysiology of acute lung injury and is intended to help caregivers understand the process and thus care for patients more effectively.

Targeting of Drugs 5 - Strategies for Oligonucleotide and Gene Delivery in Therapy (Paperback, Softcover reprint of the... Targeting of Drugs 5 - Strategies for Oligonucleotide and Gene Delivery in Therapy (Paperback, Softcover reprint of the original 1st ed. 1996)
Gregory Gregoriadis, Brenda McCormack
R1,542 Discovery Miles 15 420 Ships in 10 - 15 working days

TheNATO AdvancedStudiesInstituteseries"TargetingofDrugs"wasoriginatedin 1981. It is nowamajorinternationalforum,heldeverytwo yearsin CapeSounion,Greece,in whichthepresentandthefutureofthisimportantareaofresearch in drugdeliveryisdiscussed in greatdepth. PreviousASIsoftheseriesdealtwith drugcarriersofnaturalandsynthetic origin,theirinteractionswith thebiologicalmilieu, waysby whichthefunctionofdrugcarriers iscircumvented and,morerecently,with avarietyofapproaches to carrierdesignor modificationthatcontributeto optimalcarrierfunction. Thepresentbookcontainsthe proceedings ofthe8thNATO ASI, "TargetingofDrugs:Strategies for Oligonucleotideand GeneDelivery in Therapy", held in CapeSounionduring24June-5 July 1995. Asthetitle implies,thebookdealswith avarietyofsystemsin termsoftheirability to transportnucleic acidsto targetareasin vitro andin vivo in waysthateffectivelymodify,supplement, correct, orcurtailthefunctionofgenesin therapy. Weexpressourappreciation to Mrs. ConchaPerringfor herassistance with the organizationoftheASI. TheASI washeldunderthesponsorship ofNATO ScientificAffairs Division andco-sponsored andgenerouslyfinancedby SmithKlineBeechamPharmaceuticals (KingofPrussia). Financialassistance wasalsoprovidedby SandozPharma(Baseland Athens),GeneMedicine (Houston,USA), ChironCorporation(Emeryville,USA), BYK GuldenLombergChemische (Konstanz,Gernlany),HelpSA(Athens,Greece),Avanti Polar Lipids Inc (Birmingham,USA), OxfordMolecular(Oxford,UK), Pfizer(Kent,UK), andAlza Corporation(PaloAlto, USA). GregoryGregoriadis BrendaMcCormack v CONTENTS Gene Therapy for Inherited Genetic Disease: Possibilities and Problems c. *Coutelle Gene Delivery and Therapy: The Case for Cystic Fibrosis 15 E. W. F. W. Alton Immune Responses with Direct Gene Transfer: DNA Vaccines and 21 Implications for Gene Therapy H. L. Davis Oligonucleotides: Molecular Versions for Optimal Use in Vivo 31 E. Saison-Behmoaras, A. Van Aerschot, I. Duroux, C. Hendrix, C. Helene, and P. Herdewijn Retrovirus Vectors in Gene Therapy: Targeting to Specific Cells 45 AJ. Kingsman, Y. Bae, J. c. Griffiths, N. Kim, E. E. Ramsdale, G. Romano, Y. Soneoka, P. M. Cannon, and S. M. Kingsman Adenovirus as Vectors for Gene Therapy 53 M. G. Lee Receptor-Mediated Gene Delivery with Synthetic Virus-like Particles 67 E. Wagner, M. Cotten, and K. Zatloukal Controllable Gene Therapy: Recent Advances in Non-Viral Gene Delivery 79 A.

Drugs of Abuse, Immunity, and AIDS (Paperback, Softcover reprint of the original 1st ed. 1993): Pawel Migula, T.W. Klein, S.... Drugs of Abuse, Immunity, and AIDS (Paperback, Softcover reprint of the original 1st ed. 1993)
Pawel Migula, T.W. Klein, S. Specter
R1,584 Discovery Miles 15 840 Ships in 10 - 15 working days

This volume is based on the program of the Second International Conference on Drugs of Abuse, Immunity and AIDS, held in Clearwater Beach, FL in June 1992. The Conference was supported in part by the University of South Florida College of MediCine with financial assistance from the National Institute on Drug Abuse. The focus of this conference was the effects of drugs of abuse on immunity. It is now widely recognized that psychoactive drugs of abuse, including marijuana, cocaine, and opiates, as well as alcohol, have marked effects in an individual, including effects on their nervous system and behavior. In the past two decades, the scope of studies concerning the effects of some drugs of abuse have also involved investigations of alterations of various physiologic parameters including effects on the immune system. and the influence of such immune alterations on normal physiological responses. In this regard, participants in this Second International Conference provided newer information concerning both basic and clinical aspects of drugs of abuse and immunity, especially immunodeficiencies. In this regard, advances have been made in recent years concerning the nature and mechanisms whereby the immune system is regulated and the possible mechanisms by which drugs of abuse influence such immune systems. In particular, the emergence of psychoneuroimmunology as a new discipline the last decade has heightened interest in the immune responses influenced by psychoactive drugs. This has resulted in interdisciplinary investigations involving both clinical and basic scientists, including microbiologists, immunologists, physiologists, psychiatrists, oncologists, psychologists, etc.

Genetically Engineered Vaccines (Paperback, Softcover reprint of the original 1st ed. 1992): Joseph E. Ciardi, Jerry R. Mcghee,... Genetically Engineered Vaccines (Paperback, Softcover reprint of the original 1st ed. 1992)
Joseph E. Ciardi, Jerry R. Mcghee, Jerry M. Keith
R1,598 Discovery Miles 15 980 Ships in 10 - 15 working days

The National Institute of Dental Research sponsored a workshop on "Genetically Engineered Vaccines: Prospects for Oral Disease Prevention," held at the National Institutes of Health (NIH) on November 6-8, 1991. The purpose of the workshop was to convene molecular biologists and immunologists to address the state of the science in vaccine development and to explore the potential of developing vaccines for prevention of oral diseases. The goal was to elicit new research initiatives and recommendations for vaccine development with emphasis on the prevention of oral diseases and diseases affecting the orofacial tissues. The workshop was attended by more than 100 persons who heard 30 presentations, and the speakers provided the papers for this volume. The workshop focused on the following topics: oral diseases and host immune responses, update on vaccines and vaccine development, vaccines and the mucosal immune system, optimizing mucosal and systemic immune responses, delivery systems and immune analysis, target antigen selection and vaccine development, immunological correlates of protection and future direc tions/recommendations. Three key areas were identified: Optimizing the Mucosal Immune Response, Antigen Delivery Systems, and Target Antigens and Immunological Correlates of Protection. The summary and recommendations from these deliberations is included at the end of this volume."

Cardiac Surgery - Current Issues 2 (Paperback, Softcover reprint of the original 1st ed. 1994): A. C. Cernaianu, A. J. Delrossi Cardiac Surgery - Current Issues 2 (Paperback, Softcover reprint of the original 1st ed. 1994)
A. C. Cernaianu, A. J. Delrossi
R1,570 Discovery Miles 15 700 Ships in 10 - 15 working days

The topicS in this book represent the presentations given at the Fifth Annual Meeting entitled "Cardiac Surgery: Current Issues" held at the Frenchman's Reef Beach Resort. St. Thomas. U.S. Virgin Islands. November 11-14. 1992. This symposium was sponsored by the Division of Cardiothoracic Sur gery. the School of Cardiovascular Perfusion and the Department of Nursing Education and QUality Assurance of Cooper Hospital/University Medical Center. the University of Medicine and Dentistry of New Jersey. Robert Wood Johnson Medical School. Camden. New Jersey. as well as the Academy of Medicine of New Jersey. Chapter authors were charged with the task of writing brief overviews of major issues related to the field of cardiac surgery. The book is specifically tailored to the needs of cardiothoracic surgeons. cardiovascular perfusionists. allied health professionals and nursing personnel involved in all phases of caring for the cardiac surgical patient. Although intended as a reference source with emphasis on up-dated approaches applied in cardiac surgery. it is hoped that the discussion of these topics will compliment other texts and manuscripts. Obviously.';ibook of this length cannot cover the whole multidiSciplinary and complex field of cardiac surgery. However. co-editors are certain that the annual appearance of this text will highlight comprehensive. new and interesting approaches to the field of cardiac surgery."

Corona- and Related Viruses - Current Concepts in Molecular Biology and Pathogenesis (Paperback, Softcover reprint of the... Corona- and Related Viruses - Current Concepts in Molecular Biology and Pathogenesis (Paperback, Softcover reprint of the original 1st ed. 1995)
Gary A. Levy, Pierre J. Talbot
R1,720 Discovery Miles 17 200 Ships in 10 - 15 working days

Corona- and related viruses are important human and animal pathogens that also serve as models for other viral-mediated diseases. Interest in these pathogens has grown tremendously since the First International Symposium was held at the Institute of Virology and Immunobiology of the University of Wiirzburg, Germany. The Sixth International Symposium was held in Quebec City from August 27 to September I, 1994, and provided further understanding of the molecular biology, immunology, and pathogenesis of corona-, toro-, and arterivirus infections. Lectures were given on the molecular biology, pathogenesis, immune responses, and development of vaccines. Studies on the pathogenesis of coronavirus infections have been focused mainly on murine coronavirus, and mouse hepatitis virus. Neurotropic strains ofMHV (e.g., JHM, A59) cause a demyelinating disease that has served as an animal model for human multiple sclerosis. Dr. Samuel Dales, of the University of Western Ontario, London, Canada, gave a state-of-the-art lecture on our current under standing of the pathogenesis of JHM-induced disease.

Vaccines - Recent Trends and Progress (Paperback, Softcover reprint of the original 1st ed. 1991): Anthony C. Allison, Gregory... Vaccines - Recent Trends and Progress (Paperback, Softcover reprint of the original 1st ed. 1991)
Anthony C. Allison, Gregory Gregoriadis, George Poste
R1,531 Discovery Miles 15 310 Ships in 10 - 15 working days

The success of vaccination in controlling infectious diseases is well documented. However, low profitability, expense and liability have hindered research and development of vaccines. Recently, increasing realization (enhanced by the AIDS pandemic) of the need to overcome such difficulties has led to steps being taken by national authorities, non-profit and commercial organizations to resolve them. This has been facilitated by developments in recombinant DNA techniques, the advent of monoclonal anti bodies and progress in the understanding of the immunological structure of proteins which have laid the foundation of a new generation of vaccines. Such vaccines are defined at the molecular level, can elicit immune responses controlling infectious organisms and are therefore potentially free of the problems encountered in conventional ones. Unfortunately, subunit and synthetic peptide vaccines are often only weakly or non inmunogenic. However, developments in both antigen production and immuno potentiation of weak antigens have opened new avenues with exciting prospects for vaccine design.

Pharmacotherapy of Gastrointestinal Inflammation (Paperback, Softcover reprint of the original 1st ed. 2004): Antonio Guglietta Pharmacotherapy of Gastrointestinal Inflammation (Paperback, Softcover reprint of the original 1st ed. 2004)
Antonio Guglietta
R2,915 Discovery Miles 29 150 Ships in 10 - 15 working days

In recent years, the area of pharmacotherapy of GI inflammation has witnessed important progress, with new drugs and therapeutic approaches being introduced. The volume reviews the pharmacotherapy of selected gastrointestinal inflammatory conditions chosen on the basis of their clinical importance and/or the areas where important and exciting progress has been made recently. Besides discussing current pharmacotherapy to treat the most important GI inflammation conditions, the book also indicates possible future therapeutic avenues likely to become available in a few years.
The book is of interest to various sectors of the scientific community ranging from clinicians to pharmacologists and from biochemists to microbiologists, who will find it a useful tool for their clinical practice and research activity.

Asthma: Epidemiology, Anti-Inflammatory Therapy and Future Trends (Paperback, Softcover reprint of the original 1st ed. 2000):... Asthma: Epidemiology, Anti-Inflammatory Therapy and Future Trends (Paperback, Softcover reprint of the original 1st ed. 2000)
Mark A. Giembycz, Brian J. O'Connor
R1,533 Discovery Miles 15 330 Ships in 10 - 15 working days

1. 1. Invasive versus Non-Invasive Clinical Measurements in Medicine Clinical measurement has become an essential complement to traditional physical diagnosis. An ideal clinical measurement should be quantitative, have a high level of reliability and accuracy, be safe, acceptable to the patient, easy to perform and non-invasive. The latter demands that the technique should not break the skin or the lining epithelium and should be devoid of effects on the tissues of the body by the dissipation of energy or the introduction of infection [1]. It is therefore logical that for a given measurement, a non-invasive test will be preferred if it provides the same information with the same accuracy and precision. In the following sections, we will discuss the role of various non-invasive or relatively non-invasive methods to assess airway inflammation in asthma and concentrate on the only direct method of induced sputum examination. 1. 2. Why Is Assessment of Airway Inflammation Important in Asthma? Inflammation is a localized protective response elicited by injury or destruc tion of tissues which serves to destroy, dilute or wall off both the injurious agent and the injured tissue [2]. The role of inflammation in asthma was rec ognized long ago. In his textbook The Principles and Practice of Medicine, in 1892, Sir William Osler described "bronchial asthma . . . in many cases is a spe cial form of inflammation of the smaller bronchioles . . .

Therapeutic Immunosuppression (Paperback, Softcover reprint of the original 1st ed. 2001): A. W Thomson Therapeutic Immunosuppression (Paperback, Softcover reprint of the original 1st ed. 2001)
A. W Thomson
R1,637 Discovery Miles 16 370 Ships in 10 - 15 working days

Therapeutic immunosuppression has very broad applications in clinical medicine, ranging from prevention and treatment of organ and bone marrow transplant rejection, management of various autoimmune disorders (e.g., rheumatoid arthritis), skin disease, and asthma. Whereas traditionally only a small repertoire of immunosuppressive agents was available for clinical use, recent discoveries have significantly increased the number of approved agents, resulting in numerous trials to further evaluate their potential. In addition, products of the biotechnology industry - monoclonal antibodies, cytokines, cytokine antagonists, and other products of genetic engineering that target key molecular pathways in disease pathogenesis - have either already made, or are on the verge of making an important impact on treatment. There is also considerable interest in the potential of cell-based therapies (particularly hematopoietic stem and dendritic cell therapy) of allo- and autoimmunity. Important recent advances in the immunotherapy of allergic diseases are also covered in this book. Gene therapy offers considerable promise for suppressing pathogenic processes in either transplantation or autoimmune disorders. The possibility of combining these important new advances to maximize benefit to the patient, and to minimize possible untoward effects (which are also given extensive coverage in this book), is one of the most exciting challenges of contemporary medicine. This volume is intended both for practising physicians and surgeons and for biomedical scientists at the graduate/postdoctoral levels, and is designed to provide the theory behind these various approaches to immunosuppression, and to provide state-of-the-art reviews of current developments in each area. Each chapter is contributed by one or more experts in the field. There was a need to bring this information together in a single volume, as much of the key recent developments have been dispersed throughout the biomedical literature, largely in specialized journals. Since, as in the past, important developments in immunosuppressive therapy in one branch of medicine (i.e. transplantation) are likely to benefit another (e.g., dermatology, rheumatology, gastroenterology), cross-disciplinary coverage of the mechanistic basis of the various therapeutic strategies in a single volume is likely to convey the potential of advances in therapy in the most coherent manner possible.

Bone Morphogenetic Proteins - From Laboratory to Clinical Practice (Paperback, Softcover reprint of the original 1st ed. 2002):... Bone Morphogenetic Proteins - From Laboratory to Clinical Practice (Paperback, Softcover reprint of the original 1st ed. 2002)
Slobodan Vukicevic, Kuber T Sampath
R2,973 Discovery Miles 29 730 Ships in 10 - 15 working days

From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range of scientific topics, including biochemistry, biology, molecular biology and preclinical animal studies on spinal fusion, cartilage repair, craniofacial and dental reconstruction using BMPs, as well as approved clinical applications in human bone non-unions.

This book provides a resource not only for experts in the field, but also for undergraduate students, newcomers and clinicians worldwide, given that the use of BMPs in orthopedic reconstruction has been already approved in Europe, Australia, Canada and the USA.

Immunosuppression under Trial - Proceedings of the 31st Conference on Transplantation and Clinical Immunology, 3-4 June, 1999... Immunosuppression under Trial - Proceedings of the 31st Conference on Transplantation and Clinical Immunology, 3-4 June, 1999 (Paperback, Softcover reprint of the original 1st ed. 1999)
Pierre Cochat
R1,528 Discovery Miles 15 280 Ships in 10 - 15 working days

Immunosuppression in solid organ transplantation is currently experiencing a worldwide revival since new drugs are now available and others are under development. In order to contribute to the design of future strategies, a critical approach of surrogate endpoints is given and long-term side effects are analysed, together with the impact of non-compliance, quality-of-life and economical parameters. In this book, international specialists have set up the scientific rationale and provided new bases for further immunosuppressive strategies.

Purinergic and Pyrimidinergic Signalling II - Cardiovascular, Respiratory, Immune, Metabolic and Gastrointestinal Tract... Purinergic and Pyrimidinergic Signalling II - Cardiovascular, Respiratory, Immune, Metabolic and Gastrointestinal Tract Function (Paperback, Softcover reprint of the original 1st ed. 2001)
Maria P. Abracchio, Michael Williams
R5,815 Discovery Miles 58 150 Ships in 10 - 15 working days

Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.

Analytical Use of Fluorescent Probes in Oncology (Paperback, Softcover reprint of the original 1st ed. 1996): Elli Kohen,... Analytical Use of Fluorescent Probes in Oncology (Paperback, Softcover reprint of the original 1st ed. 1996)
Elli Kohen, Joseph G. Hirschberg
R5,849 Discovery Miles 58 490 Ships in 10 - 15 working days

Fluorescence is a very powerful tool for work at the frontier of cell biology, photobiology and bioinstrumentation. The stated aim of the workshop was to highlight the significance of fluorescence work for the understanding of cell and tissue physiology, physiopathology and pharmacology, particulary in terms of the analytical use of fluorescent probes in oncology. In the organization of the workshop a multidisciplinary approach was selected. The purpose of the Advanced Research Workshop (ARW) was to bring together researchers in the various disciplines of tissue optics, imaging, microspectrofluorometry and state of the art probes, in order to explore the full benefits that can be derived in biomedicine through the convergence of these approaches. When applied to in vivo and in situ studies, fluorescence and related optical methods enable us to explore within tissues, cells and organelles photon effects previously understood only in solution photochemistry. Processes which can be studied at the molecular level by photophysics, photochemistry and physical chemistry can be evaluated in living tissue by fluorescence spectroscopy and imaging at the intracellular level in terms of structure and function. Thus, fluorescence adds a new dimension to cell biology and physiology. This approach is now supported by a full and versatile, rapidly growing armamentarium of new selective probes for organelles, enzymes, cations, cytoskeleton and metabolic control.

Recent Developments in Graves' Ophthalmopathy (Paperback, Softcover reprint of the original 1st ed. 2000): Mark F. Prummel Recent Developments in Graves' Ophthalmopathy (Paperback, Softcover reprint of the original 1st ed. 2000)
Mark F. Prummel
R4,459 Discovery Miles 44 590 Ships in 10 - 15 working days

Recent Developments in Graves' Ophthalmopathy offers an overview of the pathogenesis, assessment and management of patients with thyroid-associated eye disease. Each chapter is written by an expert and truly represents the current state of the art on the particular topic. This book can therefore almost be considered a textbook on this enigmatic disorder. Recent Developments in Graves' Ophthalmopathy is designed for all those interested in this disease, including basic scientists, clinical endocrinologists, ophthalmologists, radiotherapists, and orbital surgeons. The book gives a comprehensive overview of all aspects of Graves' ophthalmopathy. Subjects covered include the pathology of Graves' eye disease and the controversial views on its autoimmune pathogenesis; assessment of the eye changes using reliable measurements; medical management of Graves' eye disease with an overview of the many treatment options available to the clinician, including orbital radiotherapy and other immunosuppressive treatments; management of the thyroid disease; and finally, the techniques for performing various surgical procedures, which are explained and illustrated.

The Immunological Barriers to Regenerative Medicine (Hardcover, 2013 ed.): Paul J. Fairchild The Immunological Barriers to Regenerative Medicine (Hardcover, 2013 ed.)
Paul J. Fairchild
R7,029 Discovery Miles 70 290 Ships in 10 - 15 working days

This volume offers an analysis of the scale and nature of the immunological issues facing regenerative medicine, drawing on the expertise of laboratories around the world who have taken up the challenge of applying their expertise in immunology to the vagaries of stem cell biology. In Part I, we explore the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy. Part II discusses various innovative ways of addressing the issues of immunogenicity, while, in Part III, we focus exclusively on the induction of immunological tolerance through a variety of novel approaches. It is our hope that this systematic analysis of the current state of the field will galvanise efforts to solve an issue which has so far remained intractable.

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Advances in Immunology, Volume 139
Frederick Alt Hardcover R4,417 Discovery Miles 44 170
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Douglas Wilson, Mark Cotton, … Paperback  (1)
R651 R577 Discovery Miles 5 770
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Donald L. Lee Hardcover R7,944 Discovery Miles 79 440
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Peter Parham Paperback R1,944 Discovery Miles 19 440
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Karen Frazier Paperback  (2)
R589 R510 Discovery Miles 5 100
Essentials of Clinical Immunology…
H. Chapel Paperback R1,477 R1,318 Discovery Miles 13 180
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Peter Parham Paperback  (1)
R1,450 R1,305 Discovery Miles 13 050
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Frederick Alt Hardcover R4,426 Discovery Miles 44 260
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Viviana ParreƱo Paperback R1,258 Discovery Miles 12 580

 

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