Volume I of this book provides a comprehensive discussion of the factors involved in regulation of the cell cycle, the general biological properties of growth factors, and the receptor and postreceptor mechanisms of action of these signaling agents. It evaluates the possible role of growth factors in the regulation of proto-oncogene and tumor suppressor gene expression, and the development of neoplastic processes is discussed in detail.

This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of "de-risking" that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.

MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer.

In this volume, world leaders in potato research review historical and contemporary discoveries resulting in a range of advances. Topics include nutritional quality, yield, disease and insect resistance, processing, plant growth and development, and other aspects. The book also examines research yielding significant molecular resources that facilitate breeding, linkage and gene mapping, cytology, functional and structural genomics, proteomics, and metabolomics. Future research developments that are likely to significantly advance efforts to understand and improve the potato are also explored.

Gathering together a number of experts in the world, the 27th Jerusalem Symposium was devoted to the theme of the modelling of biomolecular structures and mechanisms. As a result of recent growth in both importance and audience, the papers contained in this volume present an evaluation of the status of the present knowledge in this field. The main topics covered by this year's Symposium include nucleic acids and their interactions, proteins and their interaction, membranes and their interactions, enzymatic processes and the pharmacological and medical aspects of these subjects. Readers should benefit from the interdisciplinary approach which provides coverage of both theoretical and experimental advances.

Cancer threatens the lives of people around the world. Women, in particular, are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60, these inheritable cancers threaten women's lives, health and fertility even when they are young, before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters, Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena, a Polish oncology nurse, has spent her life treating child patients with cancer. Then, she confronts it in her own family and her own body. Kamola, a rural Indian girl, knows she has symptoms of the same disease that took her mother, but feels afraid to discuss it with her father and brothers, knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra, a doctor testing a new treatment called Neelazin, using a bacterial anticancer protein in food, to destroy cancer cells. Selena, a wealthy woman of color in Chicago, finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment, Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional, the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs, as these drugs can enter both normal and cancer cells, though preferably cancer cells, causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets, thereby becoming resistant to the drugs, as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein-protein complex formation, thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food, and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer, rather than removing the healthy tissue of the breasts and ovaries. Hopefully, they would not have to choose between fertility and survival, as is the implied message in this book, fictional as it is at this time.

Drawing on cutting-edge ideas from the biological and cognitive sciences, this book presents both an innovative neuro-computational model of language comprehension and a state-of-the-art review of current topics in neurolinguistics. It explores a range of newly-emerging topics in the biological study of language, building them into a framework which views language as grounded in endogenous neural oscillatory behaviour. This allows the author to formulate a number of hypotheses concerning the relationship between neurobiology and linguistic computation. Murphy also provides an extensive overview of recent theoretical and experimental work on the neurobiological basis of language, from which the reader will emerge up-to-date on major themes and debates. This lively overview of contemporary issues in theoretical linguistics, combined with a clear theory of how language is processed, is essential reading for scholars and students across a range of disciplines.

Key Features of the book: Simple, direct, and lucid language. Comprehensive coverage of concepts for better understanding. Well labeled illustrations, flowcharts, and tables for enhanced learning. Every chapter is followed up with a detailed summary and questionnaire. Detailed Glossary at end of the book for users to know the right words. Chapters contributed/reviewed by experienced experts in this field.

With the new techniques described in this volume, a new gene can be placed on the linkage map within only a few days. Leading researchers have updated the earlier edition to include the latest versions of DNA-based marker maps for a variety of important crops.

This book presents the basic and applied aspects of sequencing of genes and genomes and their implication in the fine-scale elucidation of the plant genomes. The third volume presents an overview on the advances of plant genomics made in the past century; deliberations on the genomics resources; concepts, tools, strategies, and achievements of comparative, evolutionary, and functional genomics and whole-genome sequencing. It also presents critical reviews on the already completed genome initiatives and glimpses on the currently progressing genome initiatives. This volume is an ideal reference book for students, scholars and scientists in academia, industry, and government.

New Findings Revolutionize Concepts of Gene Function Endogenous small RNAs have been found in various organisms, including humans, mice, flies, worms, fungi, and bacteria. Furthermore, it's been shown that microRNAs acting as cellular rheostats have the ability to modulate gene expression. In higher eukaryotes, microRNAs may regulate as much as 50 percent of gene expression. Regulation of Gene Expression by Small RNAs brings together the pioneering work of researchers who discuss their work involving a wide variety of small RNA regulatory pathways in organisms ranging from bacteria to humans. In addition to exploring the biogenesis and processing of these regulatory RNAs, they also consider the functional importance of these pathways in host organisms. Assisting current and future researchers, this unique groundbreaking work - Provides a suite of cutting-edge resources for the study of microRNA ontology and function Includes a technology guide for those seeking to assay microRNA expression Explores the mechanisms by which microRNAs regulate gene expression in animal cells, including the regulation of gene expression by RNA-mediated transcriptional gene silencing Discusses a fast and low-cost approach for reversing genetic influences in mammals Looks at breakthroughs in the use of microRNA-based therapy for HIV and cancer This volume captures the essence of the breadth and excitement surrounding the newly discovered regulatory roles of small RNAs. The powerful new approach in the study of gene function described in this text is leading to some remarkable findings that have the potential to revolutionize our understanding of genetic function and the treatment of diseases otherwise considered intractable.

Enough laws have been enacted since the adoption of the Nagoya Protocol on access and benefit-sharing to permit a study which is capable of accurately portraying the status quo of national implementation of the Protocol and the ensuing practice, emerging challenges and how countries are coping with them. This book, one of the first to present such a study, uniquely combines an examination of the new laws and practice and how they comply with the Nagoya Protocol; of issues not yet resolved by the Protocol and which solutions are being explored; and of how research and development is responding to the new situation. In addition, it proposes solutions to selected questions on ABS based on real-world and hypothetical cases, which could instigate litigation.Written by a team of expert academics and practitioners in the field, this book makes a valuable contribution to academic and policy debates and to academic literature on international environmental law, international biodiversity law, international property law, climate law and the law of indigenous populations. It also offers a reference guide for practicing lawyers in the area of ABS.

Transcriptome Analysis, by Frank Stahl, Bernd Hitzmann, Kai Mutz, Daniel Landgrebe, Miriam Lubbecke, Cornelia Kasper, Johanna Walter und Thomas Scheper Transcriptome Data Analysis for Cell Culture Processes, by Marlene Castro-Melchor, Huong Le und Wei-Shou Hu Modeling Metabolic Networks for Mammalian Cell Systems: General Considerations, Modeling Strategies, and Available Tools, by Ziomara P. Gerdtzen Metabolic Flux Analysis in Systems Biology of Mammalian Cells, by Jens Niklas und Elmar Heinzle Advancing Biopharmaceutical Process Development by System-Level Data Analysis and Integration of Omics Data, by Jochen Schaub, Christoph Clemens, Hitto Kaufmann und Torsten W. Schulz Protein Glycosylation and Its Impact on Biotechnology, by Markus Berger, Matthias Kaup und Veronique Blanchard Protein Glycosylation Control in Mammalian Cell Culture: Past Precedents and Contemporary Prospects, by Patrick Hossler Modeling of Intracellular Transport and Compartmentation, by Uwe Jandt und An-Ping Zeng Genetic Aspects of Cell Line Development from a Synthetic Biology Perspective, by L. Botezatu, S. Sievers, L. Gama-Norton, R. Schucht, H. Hauser und D. Wirth.

For all introductory genetics courses. This package includes Mastering Genetics. Teach students core genetics concepts and applications Concepts of Genetics emphasizes the fundamental ideas of genetics, while exploring modern techniques and applications of genetic analysis. This best-selling text continues to provide understandable explanations of complex, analytical topics and recognizes the importance of teaching students how to become effective problem solvers. The 12th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas and the study of posttranscriptional gene regulation in eukaryotes. An expanded emphasis on ethical considerations that genetics is bringing into everyday life is addressed in Genetics, Ethics, and Society and Case Study features. Reach every student by pairing this text with Mastering Genetics Mastering (TM) is the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools developed to engage students and emulate the office-hour experience, Mastering personalizes learning and improves results for each student. Mastering Genetics should only be purchased when required by an instructor. Please be sure you have the correct ISBN and Course ID. Instructors, contact your Pearson representative for more information.

Recent debate about the ethical and regulatory dimensions of developments in genetics has sidelined societal and cultural aspects, which arguably are indispensable for a nuanced understanding of the complexities of the topic. Regulatory and ethical debates benefit from taking seriously this 'third dimension' of culture, which often determines the configurations and limits of the space within which scientific, ethical and legal debate can take place. To fill this gap, this volume brings together contributions exploring the mutual relationships between genetics, markets, societies and identities in genetics and genomics. It draws upon the recent transdisciplinary debate on how socio-cultural factors influence understandings of 'genetics2.0' and shows how individual and collective identities are challenged or reinforced by cultural meanings and practices of genetics. This book will become a standard reference for everyone seeking to make sense of the controversies and shifts in the field of genetics in the second decade of the twenty-first century.

Southeast Asia is regarded as one of the birthplaces of modern humans. Recent genetic evidence shows that it was probably the entry point of modern humans from Africa into East Asia and Oceania. With the help of new markers X mostly from the Y-chromosome and mtDNA X several recent efforts have been made to study the populations of Southeast Asia, which have been somewhat neglected in the past.A new picture of the origin and migrations of modern humans in this region is quickly emerging. In this book, the leading researchers in the studies of Southeast Asian, East Asian, and Oceanian populations present the most up-to-date results of their research.

Bioinformatics encompasses a broad and ever-changing range of activities involved with the management and analysis of data from molecular biology experiments. Despite the diversity of activities and applications, the basic methodology and core tools needed to tackle bioinformatics problems is common to many projects. This unique book provides an invaluable introduction to three of the main tools used in the development of bioinformatics software - Perl, R and MySQL - and explains how these can be used together to tackle the complex data-driven challenges that typify modern biology. These industry standard open source tools form the core of many bioinformatics projects, both in academia and industry. The methodologies introduced are platform independent, and all the examples that feature have been tested on Windows, Linux and Mac OS. Building Bioinformatics Solutions is suitable for graduate students and researchers in the life sciences who wish to automate analyses or create their own databases and web-based tools. No prior knowledge of software development is assumed. Having worked through the book, the reader should have the necessary core skills to develop computational solutions for their specific research programmes. The book will also help the reader overcome the inertia associated with penetrating this field, and provide them with the confidence and understanding required to go on to develop more advanced bioinformatics skills.

Advances in molecular biological research in the past forty years have made the story of the gene vastly complicated: the more we learn about genes, the less sure we are of what a gene really is. Knowledge about the structure and functioning of genes abounds, but the gene has also become curiously intangible. This collection of essays renews the question: what are genes? This book is unique in that it is the first interdisciplinary volume, written by philosophers, historians, and working scientists, solely devoted to the quest for the gene. It will be of interest to professionals and students in the philosophy and history of science, genetics, and molecular biology.

Evolutionary Psychology: The Basics is a jargon-free and accessible introduction to evolutionary psychology, which examines behaviour, thoughts, and emotions in relation to evolutionary theory. Reader and Workman outline how evolutionary thinking can enhance the core areas of psychology: social, developmental, biological, cognitive, and individual differences/abnormal psychology. Covering topics such as genetics and natural selection, mate choice, culture, morality, mental health, and childhood, among others, the book integrates psychology into the biological sciences and explains the different approaches in the field by evaluating current and past evolutionary research and theory. Key studies and theories are explored in an accessible way, with the work of key evolutionary and behavioural scientists from Darwin to Dawkins examined and explained. Including a glossary and further reading, this is the essential introduction to evolutionary psychology for students of psychology and related areas, and academics and researchers, as well as anyone interested in learning more about this fascinating field.

This book, first published in 1938, is based on the Muirhead Lectures given at Birmingham University in February and March of 1937. The first half of this book is mainly devoted to an exposition of the principles of genetics, whilst the second half deals with more controversial topics, with the text providing an insight into the ideology of the time. This title will be of interest to students of politics and history.

This book focuses on drosophila as an especially useful model organism for exploring questions of evolutionary biology in the full range of evolutionary studies: population genetics, ecology, ecological genetics, speciation, phylogenetics, genome evolution, molecular evolution, and development. The author presents an integrated view of evolutionary biology as elucidated in this single organism. Special effort is made to point out holes in our knowledge and areas particularly ripe for new investigation.

Before Mendel, who came closest to the truth about heredity? This book examines the activities of sheep breeders able to transform the appearance and qualities of their stock by combining different traits of body or wool into new patterns. Exploiting what were then untried procedures - individual trait selection, very close inbreeding and progeny testing - they demonstrated inheritance from both sexes and showed how it could be stabilised. Major advances in breeding are associated with the English farmer Robert Bakewell (1725-1795). By the following century, when the same procedures had been established at breeding centres in central Europe, theory as well as practice became the subject of wider attention. In the Brno Sheep Breeders' Society, discussions of patterns of heredity finally gave way to the physiological question, 'What is inherited and how?' The question was posed by Cyrill Napp, abbot of the monastery to which Mendel was admitted six years later.

A comprehensive and critical review of the latest scientific advances in our understanding of the molecular genetics and biology of CLL and their application to the best management of CLL. The authors focus on diagnosis, prognosis, multifaceted treatment options, and complications. Among the diverse treatments considered are chemotherapy, autologous and allogenic transplantations, monoclonal antibody therapy, immunotoxin therapy, gene therapy, and several new therapeutic strategies. Familial and juvenile chronic lymphocytic leukemia are also discussed.

Contains basic and up-to-date information on an emerging fish model Allows non-specialist readers to grasp the relevance of a wide research area Provides accurate and easy to access information on each of the 30 species Includes guidance for establishing a breeding colony Documents that Anemonefishes are useful model organisms for ecological, developmental and climate research

As the world's population rises to an expected ten billion in the next few generations, the challenges of feeding humanity and maintaining an ecological balance will dramatically increase. Today we rely on just four crops for 80 percent of all consumed calories: wheat, rice, corn, and soybeans. Indeed, reliance on these four crops may also mean we are one global plant disease outbreak away from major famine.

In this revolutionary and controversial book, Jonathan Gressel argues that alternative plant crops lack the genetic diversity necessary for wider domestication and that even the Big Four have reached a "genetic glass ceiling": no matter how much they are bred, there is simply not enough genetic diversity available to significantly improve their agricultural value. Gressel points the way through the glass ceiling by advocating transgenics -- a technique where genes from one species are transferred to another. He maintains that with simple safeguards the technique is a safe solution to the genetic glass ceiling conundrum. Analyzing alternative crops -- including palm oil, papaya, buckwheat, tef, and sorghum -- Gressel demonstrates how gene manipulation could enhance their potential for widespread domestication and reduce our dependency on the Big Four. He also describes a number of ecological benefits that could be derived with the aid of transgenics.

A compelling synthesis of ideas from agronomy, medicine, breeding, physiology, population genetics, molecular biology, and biotechnology, Genetic Glass Ceilings presents transgenics as an inevitable and desperately necessary approach to securing and diversifying the world's food supply.