In this volume, world leaders in potato research review historical and contemporary discoveries resulting in a range of advances. Topics include nutritional quality, yield, disease and insect resistance, processing, plant growth and development, and other aspects. The book also examines research yielding significant molecular resources that facilitate breeding, linkage and gene mapping, cytology, functional and structural genomics, proteomics, and metabolomics. Future research developments that are likely to significantly advance efforts to understand and improve the potato are also explored.

Covering state-of-the-art technologies and a broad range of practical applications, the Third Edition of Gene Biotechnology presents tools that researchers and students need to understand and apply today's biotechnology techniques. Many of the currently available books in molecular biology contain only protocol recipes, failing to explain the principles and concepts behind the methods outlined or to inform the reader of possible pitfalls in the methods described. Filling these gaps, this book: Discusses a wide variety of approaches, from very basic methods to the latest, most sophisticated technologies Contains clearly detailed, step-by-step protocols with helpful troubleshooting tips Addresses the needs of researchers in academic and commercial environments Guides graduate students in designing, implementing, and evaluating experimental projects. Each chapter covers the principles underlying methods and techniques, and includes step-by-step descriptions of each protocol, notes, tips, and a troubleshooting guide. The book includes sections on how to write a research paper for publication in English-language journals, how to protect research discoveries and inventions via patents, and practical methods of bio-calculation. Written by a team of internationally recognized scientists, Gene Biotechnology presents protocols as well as clear and simple explanations of the key principles and concepts behind the methods. It is a single, logically organized source for the most important new methodologies. This unique resource provides the tools to help ensure success in contemporary molecular and cellular biology research.

How genes are not the only basis of heredity-and what this means for evolution, human life, and disease For much of the twentieth century it was assumed that genes alone mediate the transmission of biological information across generations and provide the raw material for natural selection. In Extended Heredity, leading evolutionary biologists Russell Bonduriansky and Troy Day challenge this premise. Drawing on the latest research, they demonstrate that what happens during our lifetimes--and even our grandparents' and great-grandparents' lifetimes-can influence the features of our descendants. On the basis of these discoveries, Bonduriansky and Day develop an extended concept of heredity that upends ideas about how traits can and cannot be transmitted across generations. By examining the history of the gene-centered view in modern biology and reassessing fundamental tenets of evolutionary theory, Bonduriansky and Day show that nongenetic inheritance-involving epigenetic, environmental, behavioral, and cultural factors-could play an important role in evolution. The discovery of nongenetic inheritance therefore has major implications for key questions in evolutionary biology, as well as human health. Extended Heredity reappraises long-held ideas and opens the door to a new understanding of inheritance and evolution.

The book presents a machine-generated literature review on CRISPR (clustered regularly interspaced short palindromic repeats) from 114 selected papers published by Springer Nature in the last few years, which are then organized by the book editors with a human-written introduction to each chapter. Each chapter presents summaries of predefined themes and provides the reader with a basis for further exploration of the topic. As one of the experimental projects initiated by Springer Nature for AI book content generation, this book shows the latest developments in the CRISPR field. It will be a useful reference for graduate students who are interested in CRISPR-related research and early-career researchers who need an overview of the current development of the field.

Mapping the genomic landscapes is one of the most exciting frontiers of science. We have the opportunity to reverse engineer the blueprints and the control systems of living organisms. Computational tools are key enablers in the deciphering process. This book provides an in-depth presentation of some of the important computational biology approaches to genomic sequence analysis. The first section of the book discusses methods for discovering patterns in DNA and RNA. This is followed by the second section that reflects on methods in various ways, including performance, usage and paradigms.

KEY TOPICS:
Ig A Deficiency
The Role of Cellular Immunity in Protection against HIV Infection
Mouse Mammary Tumour Virus: Immunological Interplays between Virus and Host
The Transporter Associated with Antigen Processing
NF-kB in cytokine gene expression
NF-kB as a target for immunosuppressive and anti-inflammatory molecules

Key Features
* A Deficiency
* The Role of Cellular Immunity in Protection against HIV Infection
* Mouse Mammary Tumor Virus: Immunological Interplays between Virus and Host
* The Transporter Associated with Antigen Processing
* NF-kB in cytokine gene expression
* NF-kB as a target for immunosuppressive and anti-inflammatory molecules

Woody plants belong to various taxonomic groups, which are heterogeneous in morphology, physiology, and geographic distribution. OtheJWise, they have neither strong evolutionruy relationships nor share a conunon habitat. They are a primaIy source of fiber and timber, and also include many edible fruit species. Their unique phenotypic behavior includes a perennial habit associated with extensive secondary growth. Additional characteristics of woody plants include: developmental juvenility and maturity with respect to growth habit, flowering time, and morphogenetic response in tissue cultures; environmental control of bud dormancy and flowering cycles; variable tolerance to abiotic stresses, wounding and pathogens; and long distance transport of water and IRltrients. Woody plants, particularly tree species, have been the focus of numerous physiological studies to understand their specialized functions, however, only recently they have become the target of molecular studies. Recent advances in our understanding of signal transduction pathways for environmental responses in herbaceous plants, including the identification and cloning of genes for proteins involved in signal transduction. should provide useful leads to undertake parallel studies with woody plants. Molecular mapping techniques, coupled with the availability of cloned genes from herbaceous plants, should provide shortcuts to cloning relevant genes from woody plants. The unique phenotypes of these plants can then be targeted for improvement through genetic engineering.

First published in 1923, this book explores the impact on development that heredity and environment has on children. Chaplin argues that too much reliance is placed on education and in fact parents, physicians and teachers should equally be taking into consideration the physical and mental constitution of the child, which could be linked to hereditary and environmental factors. In conjunction with the moral, spiritual and intellectual predispositions that the child may have, Chaplin argues the pros of eugenics (in the perspective of the early 20th century) and equally the importance of euthenics for future prosperity of generations to come.

In this volume three of the key figures in the field set out to establish some parameters for the study of creativity. After examining the earlier works on the subject, they present their current research findings, and then attempt to project where the field is likely to go in the decade ahead.

Gardner, the proponent of biological aspects of creativity, ranges widely as he examines Freud's Vienna and the features of medicine that both constrained and challenged his revolutionary idea. Csikszentmihalyi, with his exploration of genes and memes, examines individual issues as well as broader contextual concerns. Feldman concentrates on the notions of coincidence and the transformational imperative. These essays point to the rejuvenation of the field of creativity research, and suggest where the field is likely to move in the future. This work is a major synthesis of value to advanced researchers as well as students and all those concerned with creativity.

MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer.

Thoroughly Describes Biological Applications, Computational Problems, and Various Algorithmic Solutions Developed from the author's own teaching material, Algorithms in Bioinformatics: A Practical Introduction provides an in-depth introduction to the algorithmic techniques applied in bioinformatics. For each topic, the author clearly details the biological motivation and precisely defines the corresponding computational problems. He also includes detailed examples to illustrate each algorithm and end-of-chapter exercises for students to familiarize themselves with the topics. Supplementary material is available at http://www.comp.nus.edu.sg/~ksung/algo_in_bioinfo/ This classroom-tested textbook begins with basic molecular biology concepts. It then describes ways to measure sequence similarity, presents simple applications of the suffix tree, and discusses the problem of searching sequence databases. After introducing methods for aligning multiple biological sequences and genomes, the text explores applications of the phylogenetic tree, methods for comparing phylogenetic trees, the problem of genome rearrangement, and the problem of motif finding. It also covers methods for predicting the secondary structure of RNA and for reconstructing the peptide sequence using mass spectrometry. The final chapter examines the computational problem related to population genetics.

This unique introduction to the growing field of microfluidics applied to genomics provides an overview of the latest technologies and emphasizes its potential in answering important biological questions. Written by a physicist and a biologist, it offers a more comprehensive view than the previous literature. The book starts with key ideas in molecular biology, developmental biology and microtechnology before going on to cover the specifics of single cell analysis and microfluidic devices for single cell molecular analysis. Review chapters discuss the state-of-the art and will prove invaluable to all those planning to develop microdevices for molecular analysis of single cells. Methods allowing complete analysis of gene expression in the single cell are stressed - as opposed the more commonly used techniques that allow analysis of only a few genes at a time. As pioneers in the field, the authors understand how critical it is for a physicist to understand the biological issues and questions related to single cell analysis, as well for biologists to understand what microfluidics is all about. Aimed predominantly at graduate students, this book will also be of significant interest to scientists working in or affiliated with this field.

The zebrafish embryo has now been well established as an organism of choice for the genetic and cell biological basis of vertebrate development. Large-scale forward genetic screens together with reverse genetic tools have resulted in a flood of new information on the regulation of vertebrate development. Furthermore, the unique transparency of the zebrafish embryo allows unprecedented access to cells and tissues and many important discoveries on gene function have already been made using live imaging techniques in this organism. This book successfully brings together state-of-the-art methodologies of live imaging, such as the use of fluorescence correlation spectroscopy (FCS), that will be useful for investigators in the field of developmental biology to address their favorite problem using cell biological approaches in the zebrafishOne of the key reasons that has made the zebrafish such a popular vertebrate model is its transparency and its potential for high-resolution cell biology and imaging. However, there is no comprehensive and up-to-date guide to the new "live imaging" tools that can now be used in the zebrafish. Furthermore, there are many new microscopy methods that have been adapted for use in zebrafish, and this book can be a good guide even for scientists already familiar with the imaging advantages of this model.

This book presents the basic and applied aspects of sequencing of genes and genomes and their implication in the fine-scale elucidation of the plant genomes. The third volume presents an overview on the advances of plant genomics made in the past century; deliberations on the genomics resources; concepts, tools, strategies, and achievements of comparative, evolutionary, and functional genomics and whole-genome sequencing. It also presents critical reviews on the already completed genome initiatives and glimpses on the currently progressing genome initiatives. This volume is an ideal reference book for students, scholars and scientists in academia, industry, and government.

Arguing that human evolution has come to a stand-still, this book sets out to explore the evolutionary steps that have defined life on this planet. It describes the stages from cosmic to chemical and biological evolution and to the development of civilization and culture. From this scientific approach, the author concludes that new rules of ethics are required in order to maintain and improve the civilization and culture of humanity. Matare argues for corrective genetic interference and explores the moral implications.

This volume contains 18 peer-reviewed papers based on the presentations at the 10th Annual International Workshop on Bioinformatics and Systems Biology (IBSB 2010) held at Kyoto University from July 26 to July 28, 2010. This workshop started in 2001 as an event for doctoral students and young researchers to present and discuss their research results and approaches in bioinformatics and systems biology. It is part of a collaborative educational program involving leading institutions and leaders committed to the following programs:

* Boston Graduate Program in Bioinformatics, Boston University

* Berlin The International Research Training Group (IRTG) "Genomics and Systems Biology of Molecular Networks"

* Kyoto The JSPS International Training Program (ITP) "International Research and Training Program of Bioinformatics and Systems Biology"

* Tokyo Global COE Program "Center of Education and Research for Advanced Genome-Based Medicine"

Key features: Presents summaries of key points after each chapter and includes color graphs to visualize the big-picture concepts Demonstrates how urban rooftop farms (URFs) can contribute to city greening and climate change mitigation worldwide while providing fresh locally-sourced produce for growing urban populations Provides cutting-edge ideas from the the emerging field of food law and places international and comparative legal concepts into an accessible context for non-lawyers Examines major disputes surrounding food products that have been brought before the World Trade Organization (WTO) to illustrate how trade trends have pushed toward GMO proliferation Uses examples of food labeling, pollinator protection, pesticide permitting, invasive species control, and GMO regulatory policy in the US and the EU to illustrate various methods of bringing public law to the forefront in the struggle toward achieving food integrity The proliferation of Genetically Modified Organisms (GMOs) in our increasingly globalized food system is trivializing the inherent risks to a sustainable world. Responding to the realities of climate change, urbanization, and a GMO-dominated industrialized food system, Gabriela Steier's seminal work addresses the interrelationship of these cutting-edge topics within a scholarly, legal context. In Advancing Food Integrity: GMO Regulation, Agroecology, and Urban Agriculture, Steier defines food integrity as the optimal measure of environmental sustainability and climate change resilience combined with food safety, security, and sovereignty for the farm-to-fork production and distribution of any food product. The book starts with a discussion of the food system and explores whether private law has sufficiently protected food or whether public law control is needed to safeguard food integrity. It proceeds to show how the proliferation of GMOs creates food insecurity by denying people's access to food through food system centralization. Steier discusses how current industrial agricultural policy downplays the dangers of GMO monocultures to crop diversity and biodiversity, thereby weakening food production systems. Striving to promote agroecology by providing a fresh and compelling narrative of interdisciplinary questions, Steier explores how farming can be geared toward more sustainable and environmentally friendly practices worldwide in the future. This book belongs in the libraries of all those interested in food law, environmental law, agroecology, sustainable agriculture, and urban living practices.

A provocative and timely case for how the science of genetics can help create a more just and equal society In recent years, scientists like Kathryn Paige Harden have shown that DNA makes us different, in our personalities and in our health-and in ways that matter for educational and economic success in our current society. In The Genetic Lottery, Harden introduces readers to the latest genetic science, dismantling dangerous ideas about racial superiority and challenging us to grapple with what equality really means in a world where people are born different. Weaving together personal stories with scientific evidence, Harden shows why our refusal to recognize the power of DNA perpetuates the myth of meritocracy, and argues that we must acknowledge the role of genetic luck if we are ever to create a fair society. Reclaiming genetic science from the legacy of eugenics, this groundbreaking book offers a bold new vision of society where everyone thrives, regardless of how one fares in the genetic lottery.

The Genome Incorporated examines the proliferation of human genomics across contemporary media cultures. It explores questions about what it means for a technoscience to thoroughly saturate everyday life, and places the interrogation of the science/media relationship at the heart of this enquiry. The book develops a number of case studies in the mediation and consumption of genomics, including: the emergence of new direct-to-the-consumer bioinformatics companies; the mundane propagation of testing and genetic information through lifestyle television programming; and public and private engagements with art and science institutions and events. Through these novel sites, this book examines the proliferating circuits of production and consumption of genetic information and theorizes this as a process of incorporation. Its wide-ranging case studies ensure its appeal to readers across the social sciences.

White moves from a simple proposition maintaining that all individuals seek suitable surroundings to propose a provocative approach to social and political action. Rooting his position in modern life sciences and particularly in sociobiology and neurobiology, he establishes an "IMPish" model that is "interactional," "mentalist," and "populational." Interactional in that both heredity and environment are credited for due influence on individuals' traits; mentalist in that individuals' actions can be purposeful rather than simply determined; and populational in his insistence that the unique persona must not be slighted in the rush to fashion statistics. Applying his behavioral principles most notably relevant to self-selection and using examples derived from modern political action, White examines the importance of these fundamental orientations in the social and political orders. The work has implications for policy assessment and re-formulation. It constitutes a challenge to much of the widely accepted contemporary political theory and public policy approaches.

The general field of fundamental and applied biotechnology becomes increasingly important for the production of biologicals for human and veterinary use, by using prokaryotic and eukaryotic microorganisms. The papers in the present book are refereed articles compiled from oral and poster presentations from the EFB Meeting on Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology, which was organized in Semmering/A from 5th to 8th October 2000. A special feature of this meeting was the comparison of different classes of host cells, mainly bacteria, yeasts, filamentous fungi, and animal cells, which made obvious that many physiological features of recombinant protein formation, like cell nutrition, stress responses, protein folding and secretion, or genetic stability, follow similar patterns in different expression systems. This comparative aspect is by far the point of most interest because such comparisons are rarely done, and if they are done, their results are most often kept secret by the companies who generated them. Audience: Presently, a comparable book does not exist because the compiling of manuscripts from all fields of biotechnology (prokaryotic as well as eukaryotic, up to animal cell biotechnology) is not done in general. This particularity makes this book very interesting for postgraduate students and professionals in the large field of biotechnology who want to get a more global view on the current state of the expression of recombinant biologicals in different host cell systems, the physiological problems associated with the use of different expression systems, potential approaches to solve such difficulties bymetabolic engineering or the use of other host cells, and the cooperation between process development and strain improvement, which is crucial for the optimisation of both the production strain and the process. This book should be in every library of an institution/organization involved in biotechnology.

Advances in genetics have begun to deliver on their promise of new and improved approaches to the prevention and treatment of human disease, including the gene-based therapeutics. The international sports community has begun to recognize the potential harmful use of gene transfer technology by athletes. The task of monitoring and controlling sports doping must be a truly cooperative effort, involving the cooperation of a range of local, national, and international organizations. There are very serious broad social and ethical issues at stake that relate to our definition of sports and its role in our society, as well as the social and ethical principles that are challenged or breached through sport doping, determining which forms of performance enhancement - in sport or any other realm of human activity - are acceptable, and what makes the enhancement of sport performance different from enhancement in other areas of human activity (e.g., cosmetic surgery, mood and learning enhancement through drugs, and drug-based "treatment" of physical and intellectual changes in normal aging process). This book tackles all these issues and more, serving as the first such focused treatment of this increasingly important topic, which has broad-based implications for science, medicine, sports, and society.

James Mark Baldwin left a legacy that has yet to be fully examined, one with profound implications for science and the humanities. In some sense it paralleled that of his friend Charles Sanders Peirce, whose semiotics became understood only a century later. Baldwin was trying to make sense of complex biological and social processes which only now have come into the limelight as biological sciences, and slowly but surely, have re-emerged in psychology.

Baldwin's focus on development, based on the observation of his own children and extrapolated to his general theoretical scheme, is fully in line with where our contemporary biological sciences are heading. This is exemplified by the bounded flexibility of the work of the genetic system. The general principle of persistent exploration of the environment with the result of creating novelty, which was the core of Baldwin's theoretical system, has since the 1960s become the guiding idea in genetics. Contemporary developmental science is rooted in Baldwin's thinking.

In his new introduction, Jaan Valsiner shows that Baldwin's Genetic Theory of Reality demonstrates how human beings are in their nature social beings, establishes an alternative conceptualization of evolutionary theory, and formulates a system of developmental logic, all of which serve as the foundation for developmental psychology as a whole. This is a work of social science rediscovery long overdue.

The critically acclaimed laboratory standard for more than fifty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today truly an essential publication for researchers in all fields of life sciences. This new volume presents methods related to the use of bacterial genetics for genomic engineering. The book includes sections on strain collections and genetic nomenclature; transposons; and phage.