Legumes in the Omic Era provides a timely review of recent advances in legume genomics research and application. In this post-genomic era enormous amount of biological information is available which could be of huge potential use for crop improvement applications. This aspect of genomics assisted plant breeding is focused throughout the book for all the important grain legume crops. Role of functional genomics and importance of bioinformatics tools in present day genomics and molecular breeding research is also discussed in detail. Use of molecular tools for nutritional fortification of grain legume is briefly presented. A chapter also been contributed on fungal disease resistance to elucidate potential application of genomic tools in molecular breeding of grain legume species. The book contains fifteen chapters contributed by 50 scientists from different countries who are actively involved in analyzing and improving particular legume genome. This book will serve as reference resource to legumes researchers for use of genome information in improvement of major legume crops.

Dr Sanjeev Gupta is Principal Scientist/Project Coordinator-All India Coordinated Research Project on "Vigna" Crops at Indian Institute of Pulses Research (IIPR), Kanpur. He has more than two decades of research experience in grain legume breeding and developed a number of high yielding cultivars in grain legumes. He is authored numerous research papers published in peer-reviewed journals and edited several books in plant breeding aspects. He was the Organizing Secretary of the International Grain Legume Conference, 2009 held in the Indian Institute of Pulses Research, Kanpur, India. He has travelled across the continents to present his research several times. He is recipient of several awards for his research and literary contributions Dr. Nagasamy Nadarajan is the Director of the Indian Institute of Pulses Research (IIPR), Kanpur. He has more than three decades of teaching and research experience and developed more than fifteen legume and cereal cultivars. He has to his credits more than 200 peer-reviewed research publications. He has guided several graduate students for Masters and Doctoral degrees in food legume breeding and genetics research. He has authored a book in biometrics which is one of the most popular books among the agriculture graduate students in India. He is the recipient of three international and six national awards and honours for his outstanding contributions Mr. Debjyoti Sen Gupta is the ICAR International Fellow and Ph.D. candidate at North Dakota State University (NDSU), Fargo, USA. Recently, he visited Department of Crop and Soil Sciences, Washington State University, Pullman, USA for high throughput genotyping work. Before joining at NDSU he was serving as the Scientist in the Indian Institute of Pulses Research (IIPR). He has authored several research articles, review articles and book chapters in the peer-reviewed journals and books from reputed publishers like Springer, CABI etc. He is recipient of several fellowships like CSIR-JRF, New Delhi; ICAR-JRF, New Delhi throughout his graduate study programs. "

- The book discusses the recent techniques in NGS data analysis which is the most needed material by biologists (students and researchers) in the wake of numerous genomic projects and the trend toward genomic research. - The book includes both theory and practice for the NGS data analysis. So, readers will understand the concept and learn how to do the analysis using the most recent programs. - The steps of application workflows are written in a manner that can be followed for related projects. - Each chapter includes worked examples with real data available on the NCBI databases. Programming codes and outputs are accompanied with explanation. - The book content is suitable as teaching material for biology and bioinformatics students. Meets the requirements of a complete semester course on Sequencing Data Analysis Covers the latest applications for Next Generation Sequencing Covers data reprocessing, genome assembly, variant discovery, gene profiling, epigenetics, and metagenomics

The genome's been mapped.
But what does it mean?

Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.

"Genome" offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

This fifth edition volume expands on the previous editions with updated discussions on the many new in situ hybridization (ISH) techniques used by researchers today. New developments in probe designs, detection systems, specificity and sensitivity improvements, and multiplexing combinations are explored. Chapters in this book are organized into seven sections and cover general applications; methods for DNA ISH; methods for cultured cells; methods for wholemount and plant material; automated methods for RNA; multiplexing and combined methods; and targeted selective methods and single molecule detections. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, In Situ Hybridization Protocols, Fifth Edition is a valuable resource for both novice and expert scientists interested in learning more about this exciting and advancing field.

There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy, or not likely benefit, or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have a robust CDx assay or device for the success of targeted therapy and precision medicine. This book covers the technical, historical, clinical, and regulatory aspects of CDx in precision medicine. Clearly, more and more newly developed oncology drugs will require accompanying CDx assays, and this book, with chapters contributed by renowned oncologists, provides a comprehensive foundation for the knowledge and application of CDx for precision medicine.

This is the first comprehensive review of the Intergovernmental Committee (IGC) of the World Intellectual Property Organization (WIPO) established in 2000. It provides an in-depth consideration of the key thematic areas within WIPO discussions - genetic resources (GRs), traditional knowledge (TK) and traditional cultural expressions (TCEs) through the perspectives of a broad range of experts and stakeholders, including indigenous peoples and local communities. It also looks at how these areas have been treated in a number of forums and settings (including national systems and experiences, and also in trade agreements) and the interface with WIPO discussions. Furthermore, the book analyses the process and the negotiation dynamics since the IGC received a mandate from WIPO members, in 2009, to undertake formal text-based negotiations towards legal instruments for the protection of GR, TK and TCEs. While there has been some progress in these negotiations, important disagreements persist. If these are to be resolved, the adoption of these legal instruments would be a significant development towards resolving key gaps in the modern intellectual property system. In this regard, the book considers the future of the IGC and suggests options which could contribute towards achieving a consensual outcome.

Molecular Biology: Structure and Dynamics of Genomes and Proteomes 2nd edition illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous, yet still concise, summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system, Coronaviruses - structure, genome, vaccine and drug development, and newly-recognised mechanisms for transcription termination. The text is written for advanced undergraduate or graduate-level courses in molecular biology. Key Features * Highlights the experimental basis of important discoveries in molecular biology * Thoroughly updated with new information on gene editing tools, viruses, and transcription mechanisms, termination and antisense. * Provides learning objectives for each chapter. * Includes a list of relevant videos from the internet about the topics covered in the chapter.

This new volume aims to be the single book that discusses in a comprehensive and elaborate way the photosynthetic and respiratory mechanisms in plants under hostile situations and the proper mitigating strategies to continue uninterrupted photosynthesis and respiration under such situations. Since photosynthesis and respiration are the two main physiological processes for sugar biosynthesis and mobilization for driving all other vital functions, this volume delivers a wealth of sound knowledge in the related disciplines for the scientists, researchers, and academicians. With chapters from renowned scientists, researchers, and global leaders in this field, this volume focuses on the effect of environmental stressors on photosynthetic pigments, photosystems, activities of photosynthetic enzymes and protein complexes, PSII photochemistry, carbon fixation pathways, photosynthetic efficiency, glycolytic and Krebs cycle pathways, and ATP production and electron transport chain of plants. The recovery of photosynthesis and respiration through application of phytohormones, signaling molecules, and other protective agents is also emphasized. Genetic engineering to enhance photosynthetic efficiency has also been highlighted. This valuable book, Photosynthesis and Respiratory Cycles during Environmental Stress Response in Plants, will not only enable us to understand the nature of extensive damages brought to the photosynthetic and respiratory processes but will also provide a blueprint for devising proper mitigation strategies to sustain these two vital processes under challenging environmental conditions.

This book covers the many ways humans benefit from interactions with other living species. By studying animals of all kinds and sizes, from microbial organisms to elephants and whales, we can learn about their adaptations to extreme conditions on the planet Earth, about the evolutionary development of specialized capabilities, and about their ways of defending themselves against predators and diseases. The authors discuss the strengths and weaknesses of Homo sapiens, and how the study of animals can make us stronger and healthier. To deepen our knowledge of genetics, molecular and cell biology, physiology and medicine, we need to study model organisms. To cure human disease, we can learn from animals how they have evolved ways to protect themselves. To improve human performance, we can study the animal kingdom's top performers and learn from their successes. Considering these important pointers, the authors review genetic engineering techniques that can translate our existing and future animal connections into benefits for human health and performance.

Topology and Physics of Circular DNA presents comprehensive coverage of the physical properties of circular DNA. The author examines how topological constraints arising from cyclization of DNA lead to distinctive properties that make closed molecules radically different from linear DNA. The phenomenon of supercoiling, its geometric and topological analysis, and the formation of noncanonical structures in circular DNA under the influence of supercoiling are emphasized. The combination of consistent theoretical analysis and detailed treatment of major experimental approaches make Topology and Physics of Circular DNA an important reference volume for biophysicists, biochemists, molecular biologists, and researchers and students who want to expand their understanding of circular DNA.

Volume I of this book provides a comprehensive discussion of the factors involved in regulation of the cell cycle, the general biological properties of growth factors, and the receptor and postreceptor mechanisms of action of these signaling agents. It evaluates the possible role of growth factors in the regulation of proto-oncogene and tumor suppressor gene expression, and the development of neoplastic processes is discussed in detail.

In this first comprehensive analysis of biological science in modern China, Laurence Schneider traces its troubled development from the 1920s, across the 1949 boundary, and into contemporary post-socialist China. Schneider uses his detailed portrayals of influential scientists and key education and research institutions to explore both internal and external forces at work in scientific development. The author examines the largely U.S. sources of its technical development and the subsequent quality of its research and educational accomplishments. At the same time, he firmly grounds these in the context of China's national, economic, and social revolutions. These upheavals have been the source of periodic obsessions to use science to regulate nature, to manage foreign influence on science, and to control scientists. The author argues that populist 'mass science' was Mao's solution to problems of control, especially in the 1950s, when Soviet Lysenkoism was granted the power in China to monopolize biology and ban genetics. This book provides the only detailed study of Lysenkoism in China, linking its ascendance to the Great Leap Forward and the Cultural Revolution. It concludes with an analysis of the phoenix-like rise of genetics in recent decades and the assignment of biotechnology to a leading role in plans for economic development. Based on a broad range of archival materials and interviews with major actors in the story, this book will be a rich resource for all those interested in contemporary China.

This book examines life not from the reductionist point of view, but rather asks the questions: what are the universal properties of living systems, and how can one construct from there a phenomenological theory of life that leads naturally to complex processes such as reproductive cellular systems, evolution and differentiation? The presentation is relatively non-technical to appeal to a broad spectrum of students and researchers.

Technologies like CRISPR and gene drives are ushering in a new era of genetic engineering, wherein the technical means to modify DNA are cheaper, faster, more accurate, more widely accessible, and with more far-reaching effects than ever before. These cutting-edge technologies raise legal, ethical, cultural, and ecological questions that are so broad and consequential for both human and other-than-human life that they can be difficult to grasp. What is clear, however, is that the power to directly alter not just a singular form of life but also the genetics of entire species and thus the composition of ecosystems is currently both inadequately regulated and undertheorized. In Gene Editing, Law, and the Environment, distinguished scholars from law, the life sciences, philosophy, environmental studies, science and technology studies, animal health, and religious studies examine what is at stake with these new biotechnologies for life and law, both human and beyond.

Microbial species isolated from extreme and pristine habitats are always diverse, which indicates biomolecules secreted by these species might have importance. A cure for disease is a desire considering the catastrophic situations that threaten the lives of humans and animals. Currently, the world is facing the health, social and economic, and diplomatic impacts of infectious communicable diseases caused by bacteria and viruses. It is a necessity to understand the huge microbial diversity residing everywhere with us in this world. Microorganisms are species that were born at the start of “life” and will stay after the end of all other forms of life in this world. This unseen majority has significant effects on the biogeochemical cycle as well as has numerous medical and non-medical applications. So, the ability of microorganisms to produce bioactive compounds and how they can be used in different fields, especially medicine and health care, have been discussed in this book.

Arthropods are important to worldwide agriculture, food safety, human health, and energy production. Besides their practical significance, various species represent excellent model systems for biological investigations of evolution, development, physiology, reproduction, and social interaction. For these reasons, arthropod genomics is receiving increasing attention from researchers around the globe. Protocols for Cytogenetic Mapping of Arthropod Genomes is a collection of up-to-date, detailed protocols for physical chromosome mapping and their applications for studying genome organization and evolution in insects and ticks. This book brings together the expertise of cytogeneticists working on diverse groups of arthropods. Each chapter demonstrates approaches to tissue dissection, chromosome preparation, fluorescence in situ hybridization, and imaging. The book is a timely and complementary effort to the i5K initiative, which will obtain whole-genome sequences for 5,000 insect and related arthropod species. This comprehensive resource provides cytogeneticists with the necessary background and protocols to understand and develop chromosome-based genome assemblies from such whole-genome sequence data.

This volume contains papers presented at the 18th International Conference on Genome Informatics (GIW 2007) held at the Biopolis, Singapore from December 3 to 5, 2007. The GIW Series provides an international forum for the presentation and discussion of original research papers on all aspects of bioinformatics, computational biology and systems biology. Its scope includes biological sequence analysis, protein folding prediction, gene regulatory network, clustering algorithms, comparative genomics, and text mining. Boasting a history of 18 years, GIW is likely the longest-running international bioinformatics conference.A total of 16 papers were selected for presentation at GIW 2007 and inclusion in this book. The notable authors include Ming Li (University of Waterloo, Canada), Minoru Kanehisa (Kyoto University, Japan), Vladimir Kuznetsov (Genome Institute of Singapore), Tao Jiang (UC Riverside, USA), Christos Ouzounis (European Bioinformatics Institute, UK), and Satoru Miyano (University of Tokyo, Japan). In addition, this book contains abstracts from the five invited speakers: Frank Eisenhaber (Bioinformatics Institute, Singapore), Sir David Lane (Institute of Molecular and Cell Biology, Singapore), Hanah Margalit (The Hebrew University of Jerusalem, Israel), Lawrence Stanton (Genome Institute of Singapore), and Michael Zhang (Cold Spring Harbor Laboratory, USA).

Bacterial Genomes provides an in-depth review of the latest research on the structure and stability of microbial genomes, and the techniques used to analyze and "fingerprint" them. Maps of a variety of microorganisms are featured, along with articles describing their construction and relevant features. Extensive tables summarizing the different types of techniques available to analyze the genomes of these microorganisms are also presented. Among those who will find this text most useful are genome researchers, microbiologists, molecular biologists, bacteriologists, infectious disease researchers, and molecular evolutionary biologists. Researchers and students working in the field of molecular evolution in general will also be interested in this book since microbes are such popular model systems.

With recent technological advances, vast quantities of genetic and genomic data are being generated at an ever-increasing pace. The explosion in access to data has transformed the field of evolutionary genetics. A thorough understanding of evolutionary principles is essential for making sense of this, but new skill sets are also needed to handle and analyze big data. This contemporary textbook covers all the major components of modern evolutionary genetics, carefully explaining fundamental processes such as mutation, natural selection, genetic drift, and speciation. It also draws on a rich literature of exciting and inspiring examples to demonstrate the diversity of evolutionary research, including an emphasis on how evolution and selection has shaped our own species. Practical experience is essential for developing an understanding of how to use genetic and genomic data to analyze and interpret results in meaningful ways. In addition to the main text, a series of online tutorials using the R language serves as an introduction to programming, statistics, and analysis. Indeed the R environment stands out as an ideal all-purpose source platform to handle and analyze such data. The book and its online materials take full advantage of the authors' own experience in working in a post-genomic revolution world, and introduces readers to the plethora of molecular and analytical methods that have only recently become available. Evolutionary Genetics is an advanced but accessible textbook aimed principally at students of various levels (from undergraduate to postgraduate) but also for researchers looking for an updated introduction to modern evolutionary biology and genetics.

For all introductory genetics courses. Focus on essential genetic topics and explore the latest breakthroughs Known for its focus on conceptual understanding, problem solving, and practical applications, the bestselling Essentials of Genetics strengthens problem-solving skills and explores the essential genetics topics that today's students need to understand. The 10th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas, epigenetics, and genetic testing. Additionally, a new Special Topic chapter covers Advances in Neurogenetics with a focus on Huntington Disease, and new essays on Genetics, Ethics, and Society emphasize ethical considerations that genetics is bringing into everyday life. The accompanying Mastering Genetics online platform includes new tutorials on topics such as CRISPR-Cas and epigenetics, and new Dynamic Study Modules, which support student learning of key concepts and prepare them for class. Also available as a Pearson eText or packaged with Mastering Genetics: Pearson eText is a simple-to-use, mobile-optimized, personalized reading experience that can be adopted on its own as the main course material. It lets students highlight, take notes, and review key vocabulary all in one place, even when offline. Seamlessly integrated videos and other rich media engage students and give them access to the help they need, when they need it. Educators can easily share their own notes with students so they see the connection between their eText and what they learn in class - motivating them to keep reading, and keep learning. If your instructor has assigned Pearson eText as your main course material, search for: 0135588847 / 9780135588840 Pearson eText Essentials of Genetics -- Access Card, 10/e OR 0135588782 / 9780135588789 Pearson eText Essentials of Genetics -- Instant Access, 10/e Also available with Mastering Genetics By combining trusted author content with digital tools and a flexible platform, Mastering personalizes the learning experience and improves results for each student.Mastering Genetics allows students to develop problem-solving skills, learn from tutorials on key genetics concepts, and gain a better understanding of emerging topics. If you would like to purchase both the physical text and Mastering Genetics, search for: 0135173604 / 9780135173602 Essentials of Genetics Plus Mastering Genetics -- Access Card Package Package consists of: 0134898419 / 9780134898414 Essentials of Genetics 0135188687 / 9780135188682 Mastering Genetics with Pearson eText -- ValuePack Access Card -- for Essentials of Genetics Note: You are purchasing a standalone book; Pearson eText and Mastering A&P do not come packaged with this content. Students, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information.

This book presents up-to-date information on the origins of the Ashkenazic Jewish people from central and eastern Europe based on genetic research on modern and pre-modern populations. It focuses on the 129 maternal haplogroups that the author confirmed that Ashkenazim have acquired from distinct female ancestors who were indigenous to diverse lands that include Israel, Italy, Poland, Germany, North Africa, and China, revealing both their Israelite inheritance and the lasting legacy of conversions to Judaism. Genetic connections between Ashkenazic Jews and other Jewish populations, including Turkish Jews, Moroccan Jews, Tunisian Jews, Iranian Jews, and Cochin Jews, are indicated wherever they are known.

The main goal of this book is to encourage and formalize the infusion of evolutionary thinking into mainstream conservation biology. It reviews the evolutionary foundations of conservation issues, and unifies conceptual and empirical advances in evolutionary conservation biology. The book can be used either as a primary textbook or as a supplementary reading in an advanced undergraduate or graduate level course - likely to be called Conservation Biology or in some cases Evolutionary Ecology. The focus of chapters is on current concepts in evolution as they pertain to conservation, and the empirical study of these concepts. The balanced treatment avoids exhaustive reviews and overlapping duplication among the chapters. Little background in genetics is assumed of the reader.

Mapping the genomic landscapes is one of the most exciting frontiers of science. We have the opportunity to reverse engineer the blueprints and the control systems of living organisms. Computational tools are key enablers in the deciphering process. This book provides an in-depth presentation of some of the important computational biology approaches to genomic sequence analysis. The first section of the book discusses methods for discovering patterns in DNA and RNA. This is followed by the second section that reflects on methods in various ways, including performance, usage and paradigms.

This title offers 62 chapters divided among three volumes covering the latest topics dealing with Doubled Haploid (DH) technology, as well as methods to produce DHs in different species through different in vivo and in vitro approaches. Volume 1 explores general topics and transversal methods in DH technology; DH production in two alliaceae, onion, and leek; and DH production in cereals such as barley, durum, bread, oat, and japonica rice. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Doubled Haploid Technology, Volume 1: General Topics, Alliaceae, Cereals is a valuable resource for scientists and researchers looking to learn more about this interesting and developing field.