Model integration - the process by which different modelling efforts can be brought together to simulate the target system - is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale.

A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules.

The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.

This book collects papers from the 8th Conference on Non-Integer Order Calculus and Its Applications that have been held on September 20-21, 2016 in Zakopane, Poland. The preceding two conferences were held in Szczecin, Poland in 2015, and in Opole, Poland, in 2014. This conference provides a platform for academic exchange on the theory and application of fractional calculus between domestic and international universities, research institutes, corporate experts and scholars. The Proceedings of the 8th Conference on Non-Integer Order Calculus and Its Applications 2016 brings together rigorously reviewed contributions from leading international experts. The included papers cover novel various important aspects of mathematical foundations of fractional calculus, modeling and control of fractional systems as well as controllability, detectability, observability and stability problems for this systems.

This book highlights cutting-edge research in the field of network science, offering scientists, researchers and graduate students a unique opportunity to catch up on the latest advances in theory and a multitude of applications. It presents the peer-reviewed proceedings of the fifth International Workshop on Complex Networks & their Applications (COMPLEX NETWORKS 2016), which took place in Milan during the last week of November 2016. The carefully selected papers are divided into 11 sections reflecting the diversity and richness of research areas in the field. More specifically, the following topics are covered: Network models; Network measures; Community structure; Network dynamics; Diffusion, epidemics and spreading processes; Resilience and control; Network visualization; Social and political networks; Networks in finance and economics; Biological and ecological networks; and Network analysis.

< b=""> The book provides a concise description of the physical processes and mathematical models for explosions and formation of blast waves from explosions. The contents focus on quantitatively determining the energy released in the different types of explosions and the destructive blast waves that are generated. The contribution of flames, detonations and other physical processes to the explosion phenomenon is dealt with in detail. Gaseous and condensed phase explosions are discussed and the yield of explosions with their TNT equivalence is determined. Time scales involved in the explosion process and the scaling procedure are ascertained. Explosions over the ground, in water, and the interaction of explosions with objects are examined. In order to keep the text easily readable, the detailed derivation of the mathematical equations is given in the seven appendices at the end of the book. Case studies of various explosions are investigated and simple problems and their solutions are provided for the different topics to assist the reader in internalizing the explosion process. The book is a useful reference for professionals and academics in aeronautics, mechanical, civil and chemical engineering and for personnel working in explosive manufacture and high-energy materials, armaments, space, defense, and industrial and fire safety.

This monograph set presents a consistent and self-contained framework of stochastic dynamic systems with maximal possible completeness. Volume 1 presents the basic concepts, exact results, and asymptotic approximations of the theory of stochastic equations on the basis of the developed functional approach. This approach offers a possibility of both obtaining exact solutions to stochastic problems for a number of models of fluctuating parameters and constructing various asymptotic buildings. Ideas of statistical topography are used to discuss general issues of generating coherent structures from chaos with probability one, i.e., almost in every individual realization of random parameters. The general theory is illustrated with certain problems and applications of stochastic mathematical physics in various fields such as mechanics, hydrodynamics, magnetohydrodynamics, acoustics, optics, and radiophysics.

Structured Controllers for Uncertain Systems focuses on the development of easy-to-use design strategies for robust low-order or fixed-structure controllers (particularly the industrially ubiquitous PID controller). These strategies are based on a recently-developed stochastic optimization method termed the Heuristic Kalman Algorithm (HKA) the use of which results in a simplified methodology that enables the solution of the structured control problem without a profusion of user-defined parameters. An overview of the main stochastic methods employable in the context of continuous non-convex optimization problems is also provided and various optimization criteria for the design of a structured controller are considered; H infinity, H2, and mixed H2/Hinfinity each merits a chapter to itself. Time-domain-performance specifications can be easily incorporated in the design.

This book discusses various methods for designing different kinds of observers, such as the Luenberger observer, unknown input observers, discontinuous observers, sliding mode observers, observers for impulsive systems, observers for nonlinear Takagi-Sugeno fuzzy systems, and observers for electrical machines. A hydraulic process system and a renewable energy system are provided as examples of applications.

This research monograph is highly contextual in the present era of spatial/spatio-temporal data explosion. The overall text contains many interesting results that are worth applying in practice, while it is also a source of intriguing and motivating questions for advanced research on spatial data science. The monograph is primarily prepared for graduate students of Computer Science, who wish to employ probabilistic graphical models, especially Bayesian networks (BNs), for applied research on spatial/spatio-temporal data. Students of any other discipline of engineering, science, and technology, will also find this monograph useful. Research students looking for a suitable problem for their MS or PhD thesis will also find this monograph beneficial. The open research problems as discussed with sufficient references in Chapter-8 and Chapter-9 can immensely help graduate researchers to identify topics of their own choice. The various illustrations and proofs presented throughout the monograph may help them to better understand the working principles of the models. The present monograph, containing sufficient description of the parameter learning and inference generation process for each enhanced BN model, can also serve as an algorithmic cookbook for the relevant system developers.

A unique, integrated treatment of computer modeling and simulation "The future of science belongs to those willing to make the shift to simulation-based modeling," predicts Rice Professor James Thompson, a leading modeler and computational statistician widely known for his original ideas and engaging style. He discusses methods, available to anyone with a fast desktop computer, for integrating simulation into the modeling process in order to create meaningful models of real phenomena. Drawing from a wealth of experience, he gives examples from trading markets, oncology, epidemiology, statistical process control, physics, public policy, combat, real-world optimization, Bayesian analyses, and population dynamics. Dr. Thompson believes that, so far from liberating us from the necessity of modeling, the fast computer enables us to engage in realistic models of processes in , for example, economics, which have not been possible earlier because simple stochastic models in the forward temporal direction generally become quite unmanageably complex when one is looking for such things as likelihoods. Thompson shows how simulation may be used to bypass the necessity of obtaining likelihood functions or moment-generating functions as a precursor to parameter estimation. Simulation: A Modeler’s Approach is a provocative and practical guide for professionals in applied statistics as well as engineers, scientists, computer scientists, financial analysts, and anyone with an interest in the synergy between data, models, and the digital computer.

This book is offers a comprehensive overview of information theory and error control coding, using a different approach then in existed literature. The chapters are organized according to the Shannon system model, where one block affects the others. A relatively brief theoretical introduction is provided at the beginning of every chapter, including a few additional examples and explanations, but without any proofs. And a short overview of some aspects of abstract algebra is given at the end of the corresponding chapters. The characteristic complex examples with a lot of illustrations and tables are chosen to provide detailed insights into the nature of the problem. Some limiting cases are presented to illustrate the connections with the theoretical bounds. The numerical values are carefully selected to provide in-depth explanations of the described algorithms. Although the examples in the different chapters can be considered separately, they are mutually connected and the conclusions for one considered problem relate to the others in the book.

This self-contained text develops a Markov chain approach that makes the rigorous analysis of a class of microscopic models that specify the dynamics of complex systems at the individual level possible. It presents a general framework of aggregation in agent-based and related computational models, one which makes use of lumpability and information theory in order to link the micro and macro levels of observation. The starting point is a microscopic Markov chain description of the dynamical process in complete correspondence with the dynamical behavior of the agent-based model (ABM), which is obtained by considering the set of all possible agent configurations as the state space of a huge Markov chain. An explicit formal representation of a resulting "micro-chain" including microscopic transition rates is derived for a class of models by using the random mapping representation of a Markov process. The type of probability distribution used to implement the stochastic part of the model, which defines the updating rule and governs the dynamics at a Markovian level, plays a crucial part in the analysis of "voter-like" models used in population genetics, evolutionary game theory and social dynamics. The book demonstrates that the problem of aggregation in ABMs - and the lumpability conditions in particular - can be embedded into a more general framework that employs information theory in order to identify different levels and relevant scales in complex dynamical systems

First book on the subject, illustrative examples, some original results, self-contained material, a reference book.

The biennial CONTROLO conferences are the main events promoted by The CONTROLO 2016 - 12th Portuguese Conference on Automatic Control, Guimaraes, Portugal, September 14th to 16th, was organized by Algoritmi, School of Engineering, University of Minho, in partnership with INESC TEC, and promoted by the Portuguese Association for Automatic Control - APCA, national member organization of the International Federation of Automatic Control - IFAC. The seventy-five papers published in this volume cover a wide range of topics. Thirty-one of them, of a more theoretical nature, are distributed among the first five parts: Control Theory; Optimal and Predictive Control; Fuzzy, Neural and Genetic Control; Modeling and Identification; Sensing and Estimation. The papers go from cutting-edge theoretical research to innovative control applications and show expressively how Automatic Control can be used to increase the well being of people.

This volume collects various contributions from the 5th International Conference on Jets, Wakes and Separated Flows (ICJWSF2015) that took place in Stockholm during June 2015. Researchers from all around the world presented their latest results concerning fundamental and applied aspects of fluid dynamics. With its general character, the conference embraced many aspects of fluid dynamics, such as shear flows, multiphase flows and vortex flows, for instance. The structure of the present book reflects the variety of topics treated within the conference i.e. Jets, Wakes, Separated flows, Vehicle aerodynamics, Wall-bounded and confined flows, Noise, Turbomachinery flows, Multiphase and reacting flows, Vortex dynamics, Energy-related flows and a section dedicated to Numerical analyses.

This book provides its reader with a good understanding of the stabilization of switched nonlinear systems (SNS), systems that are of practical use in diverse situations: design of fault-tolerant systems in space- and aircraft; traffic control; and heat propagation control of semiconductor power chips. The practical background is emphasized throughout the book; interesting practical examples frequently illustrate the theoretical results with aircraft and spacecraft given particular prominence.

Stabilization of Switched Nonlinear Systems with Unstable Modes treats several different subclasses of SNS according to the characteristics of the individual system (time-varying and distributed parameters, for example), the state composition of individual modes and the degree and distribution of instability in its various modes. Achievement and maintenance of stability across the system as a whole is bolstered by trading off between individual modes which may be either stable or unstable or by exploiting areas of partial stability within all the unstable modes.

The book can be used as a reference for academic research on switched systems or used by graduate students of control theory and engineering. Readers should have studied linear and nonlinear system theory and have some knowledge of switched and hybrid systems to get the most from this monograph.

This book simultaneously presents the theory and the numerical treatment of elliptic boundary value problems, since an understanding of the theory is necessary for the numerical analysis of the discretisation. It first discusses the Laplace equation and its finite difference discretisation before addressing the general linear differential equation of second order. The variational formulation together with the necessary background from functional analysis provides the basis for the Galerkin and finite-element methods, which are explored in detail. A more advanced chapter leads the reader to the theory of regularity. Individual chapters are devoted to singularly perturbed as well as to elliptic eigenvalue problems. The book also presents the Stokes problem and its discretisation as an example of a saddle-point problem taking into account its relevance to applications in fluid dynamics.

for one year from the date of release.

This book presents a collection of research findings and proposals on computer science and computer engineering, introducing readers to essential concepts, theories, and applications. It also shares perspectives on how cutting-edge and established methodologies and techniques can be used to obtain new and interesting results. Each chapter focuses on a specific aspect of computer science or computer engineering, such as: software engineering, complex systems, computational intelligence, embedded systems, and systems engineering. As such, the book will bring students and professionals alike up to date on key advances in these areas.

This book offers the first systematic account of canard cycles, an intriguing phenomenon in the study of ordinary differential equations. The canard cycles are treated in the general context of slow-fast families of two-dimensional vector fields. The central question of controlling the limit cycles is addressed in detail and strong results are presented with complete proofs. In particular, the book provides a detailed study of the structure of the transitions near the critical set of non-isolated singularities. This leads to precise results on the limit cycles and their bifurcations, including the so-called canard phenomenon and canard explosion. The book also provides a solid basis for the use of asymptotic techniques. It gives a clear understanding of notions like inner and outer solutions, describing their relation and precise structure. The first part of the book provides a thorough introduction to slow-fast systems, suitable for graduate students. The second and third parts will be of interest to both pure mathematicians working on theoretical questions such as Hilbert's 16th problem, as well as to a wide range of applied mathematicians looking for a detailed understanding of two-scale models found in electrical circuits, population dynamics, ecological models, cellular (FitzHugh-Nagumo) models, epidemiological models, chemical reactions, mechanical oscillators with friction, climate models, and many other models with tipping points.

With the intriguing development of technologies in several industries, along with the advent of ubiquitous computational resources, there are now ample opportunities to develop innovative computational technologies in order to solve a wide range of issues concerning uncertainty, imprecision, and vagueness in various real-life problems. The challenge of blending modern computational techniques with traditional computing methods has inspired researchers and academics alike to focus on developing innovative computational techniques. In the near future, computational techniques may provide vital solutions by effectively using evolving technologies such as computer vision, natural language processing, deep learning, machine learning, scientific computing, and computational vision. A vast number of intelligent computational algorithms are emerging, along with increasing computational power, which has significantly expanded the potential for developing intelligent applications. These proceedings of the International Conference on Inventive Computation Technologies [ICICT 2019] cover innovative computing applications in the areas of data mining, big data processing, information management, and security.

This book explores Probabilistic Cellular Automata (PCA) from the perspectives of statistical mechanics, probability theory, computational biology and computer science. PCA are extensions of the well-known Cellular Automata models of complex systems, characterized by random updating rules. Thanks to their probabilistic component, PCA offer flexible computing tools for complex numerical constructions, and realistic simulation tools for phenomena driven by interactions among a large number of neighboring structures. PCA are currently being used in various fields, ranging from pure probability to the social sciences and including a wealth of scientific and technological applications. This situation has produced a highly diversified pool of theoreticians, developers and practitioners whose interaction is highly desirable but can be hampered by differences in jargon and focus. This book - just as the workshop on which it is based - is an attempt to overcome these difference and foster interest among newcomers and interaction between practitioners from different fields. It is not intended as a treatise, but rather as a gentle introduction to the role and relevance of PCA technology, illustrated with a number of applications in probability, statistical mechanics, computer science, the natural sciences and dynamical systems. As such, it will be of interest to students and non-specialists looking to enter the field and to explore its challenges and open issues.

Introduction to Theory of Control in Organizations explains how methodologies from systems analysis and control theory, including game and graph theory, can be applied to improve organizational management. The theory presented extends the traditional approach to management science by introducing the optimization and game-theoretical tools required to account for the special nature of human beings being viewed as control objects. The book introduces a version of mechanism design that has been customized to solve the problems that today's managers must contend with. All mathematical models and mechanisms studied are motivated by the most common problems encountered by managers in firms and non-profit organizations. Requiring no prior knowledge of game theory or mechanism design, the book includes a systematic introduction to the underlying methodology of modern theory of control in organizations. The authors use formal methods to construct robust and efficient decision-making procedures which support all aspects and stages of management activity over all decision horizons-from operational to strategic management. The mathematical and methodological backgrounds of the organizational mechanisms discussed are not limited to game theory but also include systems analysis, control theory, operations research, and discrete mathematics. The book includes a set of exercises in each chapter-from simple to advanced-that provide the reader with the understanding required to integrate advanced methods of optimization, game theory, and mechanism design into daily managerial practice.

This book addresses the challenging topic of modeling adaptive networks, which often manifest inherently complex behavior. Networks by themselves can usually be modeled using a neat, declarative, and conceptually transparent Network-Oriented Modeling approach. In contrast, adaptive networks are networks that change their structure; for example, connections in Mental Networks usually change due to learning, while connections in Social Networks change due to various social dynamics. For adaptive networks, separate procedural specifications are often added for the adaptation process. Accordingly, modelers have to deal with a less transparent, hybrid specification, part of which is often more at a programming level than at a modeling level. This book presents an overall Network-Oriented Modeling approach that makes designing adaptive network models much easier, because the adaptation process, too, is modeled in a neat, declarative, and conceptually transparent Network-Oriented Modeling manner, like the network itself. Thanks to this approach, no procedural, algorithmic, or programming skills are needed to design complex adaptive network models. A dedicated software environment is available to run these adaptive network models from their high-level specifications. Moreover, because adaptive networks are described in a network format as well, the approach can simply be applied iteratively, so that higher-order adaptive networks in which network adaptation itself is adaptive (second-order adaptation), too can be modeled just as easily. For example, this can be applied to model metaplasticity in cognitive neuroscience, or second-order adaptation in biological and social contexts. The book illustrates the usefulness of this approach via numerous examples of complex (higher-order) adaptive network models for a wide variety of biological, mental, and social processes. The book is suitable for multidisciplinary Master's and Ph.D. students without assuming much prior knowledge, although also some elementary mathematical analysis is involved. Given the detailed information provided, it can be used as an introduction to Network-Oriented Modeling for adaptive networks. The material is ideally suited for teaching undergraduate and graduate students with multidisciplinary backgrounds or interests. Lecturers will find additional material such as slides, assignments, and software.

This book presents theoretical and practical findings on the state estimation, diagnosis and control of complex systems, especially in the mathematical form of descriptor systems. The research is fully motivated by real-world applications (i.e., Barcelona's water distribution network), which require control systems capable of taking into account their specific features and the limits of operations in the presence of uncertainties stemming from modeling errors and component malfunctions. Accordingly, the book first introduces a complete set-based framework for explicitly describing the effects of uncertainties in the descriptor systems discussed. In turn, this set-based framework is used for state estimation and diagnosis. The book also presents a number of application results on economic model predictive control from actual water distribution networks and smart grids. Moreover, the book introduces a fault-tolerant control strategy based on virtual actuators and sensors for such systems in the descriptor form.