How are pharmaceutical technologies developed and controlled in our societies? To what extent should the availability of these technologies be determined by scientific experts, a democratic state, the interests of final users, or ethical principles? This unique collection brings together the work of social scientists, ethicists, lawyers, and policy analysts on regulation, ethics and innovation in the pharmaceutical industry. Regulatory systems and their implications for public health in North America, Europe, and developing countries are discussed, including case studies of norplant, interferon, and anti-fertility vaccines.

Following World War II, the U.S. manufacturing sector emerged as the dominant industrial force in the world in virtually all areas, including productivity, market share, innovations, and capital investments. Though other countries have caught up with and surpassed the United States in many industries, Romesh Diwan and Chandana Chakraborty argue that America can recapture its dominant role by moving forcefully into high-technology industries. In this work, they examine competitiveness in a range of high-technology enterprises, analyzing the industries as an aggregate as well as through three specific examples: semi-conductors, telecommunications, and computers. The authors provide a complete understanding of the technical changes and developments that are taking place in U.S. high technology, and offer guidance to policy makers in promoting competitive strength. Their work defines and quantifies the high-tech industrial sector of the U.S, economy, and analyzes the productivity of this sector by utilizing a translog cost function, which provides information about the structure of the input-output relations in a particular industry. Using these functions, Diwan and Chakraborty answer quantitatively a number of questions relating to the growth of various inputs, productivities, and outputs, which lead to conclusions regarding the structure of production, costs, and capacity in U.S. industry. Their conclusions--that technical change is biased in the main in favor of capital and material, and that capital and skilled labor are complements--are consistent with new ideas and theories in the field. This work will be a valuable reference source for professional economists and policy experts, as well as for scholars and students in international trade, finance, and development.

'Highly recommended as a thorough examination of the commodity history of salt'-The Geographical Journal. Salt has been called the primordial addiction. It has been an object of almost universal consumption since Neolithic times. This book sets out to place the particular histories of salt in a global perspective and write the history of a human commodity as a theme in world history. From pagan man, through classical Rome, Byzantium, early Islam, the Dark Ages, the Renaissance to the modern world, the production, distribution, consumption and taxation of salt are examined. The author shows how a history of salt cannot be separated from the histories of commerce, medicine, diet, cooking, taxation, invention and war. Although taken for granted today, salt has been of critical economic and cultural importance to countries and peoples throughout history; the instigator and catalyst to actions and events ranging from the first maritime expedition of Muslim forces to Columbus's discovery of America. After Salt and Civilization salt can not be taken for granted again.

The book arose from a multi-disciplinary study which looked at the development of global-local manufacturing clusters in the context of a developing, Asian economy. The study demonstrates the connection amongst theoretical perspectives such as international business, development studies, economic geography, organizational learning clusters/production networks through an in-depth case study of the Indonesian automotive cluster. The book gives a detailed account of two automotive clusters (Toyota and Honda) and their contribution to regional economic development in emerging economies in Asian region. The book builds on several literature to develop a theoretical framework to shed light on the empirical findings of the study.

The book discusses practical implications for both the business community and policy makers. The discussion on global-local networks in an Asian context supplements existing literature and case studies in the field. This is one of the very few books which explicitly links regional clusters to global networks. The book offers a refreshingly international (Asian) perspective to the literature on clusters and economic geography for emerging economies.

Food Chains: Quality, Safety and Efficiency in a Challenging World addresses the many issues facing European food producers and other food chain stakeholders, who endeavour to improve their competitive position in a highly competitive world food market.

The Food Chain is one of the main economic pillars in Europe, providing employment and opportunities for economic development in rural areas. It is therefore imperative to continuously monitor the changes that affect the sector, in order to allow stakeholders to respond promptly and effectively to the new market conditions. Adjusting to the new market involves new technology, globalization, demographic and social changes within a challenging market environment. In order to adopt these new market parameters, food chain stakeholders need to adapt their activities in order to gain in terms of effectiveness and efficiency.

This book was originally published as a special issue of Food Economics - Acta Agriculture Scandinavica, Section C.

This volume presents a multi-faceted view of the set of problems that the electronic industry currently faces in the development and integration of complex heterogeneous systems (including both hardware and software components). It analyses and proposes solutions related to the provision of integration platforms by SoC and IP providers in light of the needs and requirements expressed by the system companies: they are the users of such platforms which they apply to develop their next generation products. Further, the book tries to draw a comprehensive picture of the current interfaces between the platform providers and users, defined by technical requirements, current design methodology and flows, standards, and finally by the business context and relationships (which should not to be underestimated).

A study of the powerful impact that sugar had on U.S.-Dominican relations as the primary vehicle of reciprocal manipulation from 1958 to 1962, Sugar and Power examines the development of the sugar industry in the Dominican Republic. Hall uncovers new evidence that supports the belief that U.S.-Latin American relations during this period were frequently a two-way street, with the United States reacting to Latin American initiatives just as frequently as Latin Americans responded to American initiatives. Both Eisenhower and Kennedy used sugar quota legislation as a foreign policy tool. At the same time, the Trujillo regime played upon Washington's fear of communism in response to the Cuban revolution to obtain an expanded sugar quota. Drawing heavily on U.S. and Dominican government documents, this study argues that the U.S. initiated economic sanctions against Trujillo to gain hemispheric support against Castro's Cuban revolution. Kennedy expanded those sanctions in an attempt to push the Dominican Republic along the path toward democracy. Although Juan Bosch's election at the end of 1962 and the allotment of a generous sugar quota indicated the apparent success of U.S. foreign policy toward the Dominican Republic, the overthrow of Bosch in 1963 indicated that the path toward democracy was longer than American policy makers had anticipated. This case study in the role of economic coercion in U.S.-Latin American relations during the Cold War tries to present a balanced account of both sides of the story.

There is widespread concern amongst consumers about the safety and acceptability of food, and there are clearly communication gaps between consumers, many food professionals and food industry. This book offers accounts of the two-way nature of this difficult communication process and steps that can be made to bridge these communication gaps in a variety of social and cultural environments. Individual chapters of the book analyze the roles of science, culture, and risk perception, and of mass media and attitudes towards eating. An additional section describes the interface between scientists and lay people with regard to policy-making and agricultural practice.

* One of the first critiques of participatory design processes that are currently the fashion in design and business * highlights political, social and methodological obstacles when designers turn to design thinking, participation and "living labs" * uses global examples to introduce a more critical and post-colonial perspective on participation and social innovation throughout the book

First published in 1985, this book is about Imperial Chemical Industriesa (TM) response to the changing social, political, business and economic environment over the past twenty years. Using personal interviews and archival material, Andrew Pettigrew examines the evolution of business strategy, organisation structure and culture, technology and union-management relations within this corporate giant over an extended period of time. It is a compelling account, told from the inside, by one of the worlda (TM)s leading management and organisation theorists. The Awakening Giant has made a major practical and theoretical contribution to the study of corporate strategy, organisational analysis and change, and business history. Anyone with an interest in managing change in a large corporation will find this reissue rewarding reading.

"This book shows why contests over intellectual property rights and access to affordable medicines emerged in the 1990s and how they have been resolved so far. It argues that the current arrangement mainly ensures wealth for some rather than health for all, and points to broader concerns related to governing intellectual property solely as capital"--Provided by publisher.

Like cotton, indigo has defied its humble origins. Left alone it might have been a regional plant with minimal reach, a localized way of dyeing textiles, paper, and other goods with a bit of blue. But when blue became the most popular color for the textiles that Britain turned out in large quantities in the eighteenth century, the South Carolina indigo that colored most of this cloth became a major component in transatlantic commodity chains. In "Red, White, and Black Make Blue," Andrea Feeser tells the stories of all the peoples who made indigo a key part of the colonial South Carolina experience as she explores indigo's relationships to land use, slave labor, textile production and use, sartorial expression, and fortune building.
In the eighteenth century, indigo played a central role in the development of South Carolina. The popularity of the color blue among the upper and lower classes ensured a high demand for indigo, and the climate in the region proved sound for its cultivation. Cheap labor by slaves--both black and Native American--made commoditization of indigo possible. And due to land grabs by colonists from the enslaved or expelled indigenous peoples, the expansion into the backcountry made plenty of land available on which to cultivate the crop. Feeser recounts specific histories--uncovered for the first time during her research--of how the Native Americans and African slaves made the success of indigo in South Carolina possible. She also emphasizes the material culture around particular objects, including maps, prints, paintings, and clothing. "Red, White, and Black Make Blue" is a fraught and compelling history of both exploitation and empowerment, revealing the legacy of a modest plant with an outsized impact.

Despite the fact that Rubber is one of the world's major commodities, surprispingly little has been written about hte the subject. First published in 1994, The World Rubber Industry seeks to redress this deficiency. It presents information in a clear and accessible manner, with numerous tables and illustrations, and an extensive glossary. This is a comprehensive and definitive analysis of one of the world's major and most essential commodities.

The pharmaceutical industry has encountered major shifts in recent years, both within the industry, and in its external environment. The cost of healthcare rising due to an ageing population, the intensification of regulatory requirements and mergers within the industry have led to an increased need for restructuring, cost reduction and culture change projects. Project management is the key to addressing these needs, and also to effective drug development. Given the costs of development and the critical issue of 'time to market', project management techniques - appropriately used - are a key factor in bringing a drug to market. In this book, Laura Brown and Tony Grundy's pharmaceutical expertise and experience offers the reader a guide to the most relevant project management tools and techniques and how to rigorously apply them in the pharmaceutical industry. The authors cover the technical, strategic and human aspects of project management, including contingency planning, simulation techniques and different project options. Complete with decision-tree diagrams, checklists, exercises and a full glossary, Project Management for the Pharmaceutical Industry provides clinical research, drug development and quality assurance managers or directors with a one-stop reference for successfully managing pharmaceutical projects. The text has been revised for this edition and now includes some additional material on risk management.

This three-volume set of Pharmaceutical Dosage Forms: Parenteral Medications is an authoritative, comprehensive reference work on the formulation and manufacture of parenteral dosage forms, effectively balancing theoretical considerations with the practical aspects of their development. As such, it is recommended for scientists and engineers in the pharmaceutical industry and academia, and will also serve as an excellent reference and training tool for regulatory scientists and quality assurance professionals.

First published in 1984 (as two volumes) and then last revised in 1993 (when it grew to three volumes), this latest revision will address the plethora of changes in the science and considerable advances in the technology associated with these products and routes of administration. The third edition of this book maintains the features that made the last edition so popular but comprises several brand new chapters, revisions to all other chapters, as well as high quality illustrations.

Volume one presents:

A historical perspective of injectable drug therapy, common routes of administration, and biopharmaceutics of NCEs and NBEs.

An in-depth discussion on the preformulation and formulation of small and large molecules, including ophthalmic dosage forms.

A presentation of parenteral primary packaging options - glass and plastic containers, as well as elastomeric closures.

A definitive chapter on container-closure integrity.

New chapters on solubility and solubilization, formulation of depot delivery systems and biophysical/biochemical characterization of proteins.

Volume two presents:

Chapters on aseptic facility design, environmental monitoring, and cleanroom operations.

A comprehensive chapter on pharmaceutical water systems.

A discussion of quality attributes of sterile dosage forms, including particulate matter, endotoxin, and sterility testing.

A detailed chapter on processing of parenteral drug products (SVPs and LVPs).

Presentations on widely used sterilization technologies steam, gas / chemical, radiation, filtration and dry heat.

An in-depth chapter on lyophilization.

Volume three presents:

An in-depth discussion of regulatory requirements, quality assurance, risk assessment and mitigation, and extractables/leachables.

Specific chapters on parenteral administrations devices, injection site pain assessment, and parenteral product specifications and stability testing.

Forward-thinking discussions on the future of parenteral product manufacturing, and siRNA delivery systems.

New chapters covering recent developments in the areas of visual inspection, quality by design (QbD), process analytical technology (PAT) and rapid microbiological methods (RMM ), and validation of drug product manufacturing process.

Fermentation and Food Safety covers the issues and processes that influence and affect the safety of fermented foods. Beginning with an explanation of fermented foods, basic safety issues, and the HACCP system, this contributed volume explores fermented foods associated with food-borne illnesses, including details of specific cases, causative agents, and the underlying reasons for their presence. The book deals individually with relevant chemical and microbiological hazards that may threaten public health, covering severity, rate of occurrence, introduction into foods, foods specifically at risk, and conditions that remove or inactivate these hazards. 'Fermentation and Food Safety' also looks at the impact of currently employed and novel fermentation processes and starters on hazards, with a specific focus on biotechnology issues. This unique reference is pertinent to the safe production of fermented foods at all scales, with all major food groups, and should be a valuable resource for anyone involved in research, processing, safety, or quality of fermented foods.

This book develops a model for analyzing the relationships of the defense industry with the productive infrastructure, the political constraints, and the technological capabilities of a semi-industrialized country. This model is used as the base for the analysis of the defense industries of semi-industrialized Latin-American countries that have shown a proven capacity to produce and export indigenous defense equipment: Argentina, Brazil and Chile. The defense industries of these three countries are described and analyzed in depth, with the objective of determining the reasons for their varying performance and of assessing the effects, positive or negative, on their respective national economies.

Manufacturing in the UK has an image problem. Although this image problem is more fiction than fact, it nonetheless has an impact on the sector's ability to attract staff, capital, and policy interest. This book redresses this situation by focusing on the real successes of the sector and the strategies used by makers to achieve sustainable results.

Through developing an original analytical framework that, for the first time, systematically relates productive, market and financial variables, the authors are able to rewrite the history of the car business since Henry Ford.

Supply chain management helped companies to manage volumes, fulfil customer demand and optimize costs in production and distribution. Specifically, chemical industry companies with high complexity in production and distribution used supply chain management to steer their operations. Confronted with globalization and increasing raw material and sales price volatility, optimizing supply chain costs is no longer sufficient to ensure the overall profitability of the business. Value chain management takes supply chain management to the next level by integrating all volume and value decisions from sales to procurement. The book presents the value chain management concept and demonstrates how it is applied in a global value chain planning model for commodities in the chemical industry. A comprehensive industry case study illustrates the effects of decision making integration, e.g. the influence of raw material prices or exchange rates on optimal sales, production, distribution and procurement plans as well as overall company profitability.

This highly specialized volume examines the Strategic Defense Initiative (SDI) for the first time, with critical emphasis on the impact SDI will have on technologically based industries. It reviews the policies and structures in the government, academia, and industry necessary to take full advantage of the commercial potential of the benefits-to-come from the SDI research program.

Until the eighteenth century or even later, beer was the staple drink of most men and women at all levels of society. Tea and coffee were expensive luxuries while water might well carry disease. To supply the needs of both owners and servants, every country house with an accessible source of water had a brewhouse, usually close at hand. Although many of the brewhouses still stand, in some cases with the original brewing vessels (as at Lacock and Charlecote), their habitual conversion to other uses has allowed them to be ignored. Yet they are distinctive buildings - as much part of a country house as an ice-house or stables - which need both to be recognised and preserved.
The scale of brewing in country houses, which went on to a surprisingly late date in the nineteenth century (with odd survivals, such as Hickleton in Yorkshire, into the twentieth), was often considerable, if small besides that of commercial brewing. Copious records for both brewing and consumption exist. Pamela Sambrook describes the brewing equipment, such as coppers, mash tuns underbacks and coolers; the types of beers brewed, from strong ale to small beer and how they were kept; and the brewers themselves, their skills and attitudes.
"English Country House Brewing, 1500-1900" shows the role beer played in the life of the country house, with beer allowances and beer money an integral part of servants' rewards. Generous allowances were made for arduous tasks, such as harvesting. For celebrations, such as the heir's coming of age, extra-strong ale was provided. This book, which is heavily illustrated, is an important and original contribution to architectural, brewing and social history.

After marked reductions in military spending in the 1990s, military budgets around the world are on the increase. In this book, renowned authorities re-examine the economics of military expenditure, arms production and arms trade in developing nations. It includes analysis of military spending in Africa, Asia, and Latin America and new forms of civil conflict as well as nine case studies (Saudi Arabia, South Africa, Mozambique, Angola, sub-Saharan Africa, Greece, Turkey, Guatemala, and Chile). The book will serve as a valuable contribution to the fields of both development economics and security studies.