Transfer pricing is considered a new and complex concept in terms of guidelines and regulations. In this context, more and more academics and tax professionals are interested in understanding the mechanism of a transfer pricing analysis. The main objective of the book is to help them in this process by presenting in a practical approach (using case studies and schemes) and in accordance with the OECD Transfer Pricing Guidelines for Multinational Enterprises and Tax Administrations the way in which are operating the basic transfer pricing elements. Moreover, considering that the manufacturing sector is the chief wealth-producing sector of the global economy, the book illustrates complete transfer pricing analyses applicable for manufacturing transactions (using Orbis database). In the end, the book presents some recent disputes between manufacturing entities and tax authorities in relation to the transfer pricing analysis for manufacturing transactions. Chapter "TAMSAT" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

The new millennium has carried several challenges for patent law. This up-to-date book provides readers with an important overview of the most critical issues patent law is still facing today at the beginning of the twenty first century, on both sides of the Atlantic. New technological sectors have emerged, each one with its own features with regard to innovation process and pace. From the most controversial cases in biotech to the most recent decisions in the field of software and business methods patent, patent law has tried to stretch its boundaries in a way to accommodate such new and controversial subject matters into its realm. Biotechnology and Software Patent Law will strongly appeal to postgraduate students specializing in IP law, international law, commercial and business law, competition law as well as IP scholars, academics and lawyers. Contributors: S.D. Anderman, R.B. Bakels, S.J.R. Bostyn, D.L. Burk, V. Di Cataldo, V. Falce, C. Geiger, R.M. Hilty, C.M. Holman, M.A. Lemley, A. Ottolia, J. Pila, J.R. Thomas, P.L.C. Torremans

Soon to be the major motion picture Pain Hustlers starring Emily Blunt and Chris Evans streaming on Netflix ‘A pacey crime caper set against the backdrop of the opioid crisis . . . When I tell you that reading The Hard Sell is like watching a Scorsese film, you will assume I am exaggerating. Pick it up and tell me I’m wrong.' - Patrick Radden Keefe, The New York Times In the early 2000s, John Kapoor had already amassed a small fortune in pharmaceuticals when he founded Insys Therapeutics. A boom time for painkillers, he had developed a novel formulation of fentanyl, the most potent opioid on the market. Kapoor, a brilliant scientist with relentless business instincts, was eager to make the most of his innovation. But there was a problem: the drug was approved only for cancer patients in dire condition. So he recruited an avaricious team, who employed a variety of deceptive techniques, from falsifying patient records to deceiving insurance companies. Insys became a Wall Street sensation. That is, until insiders reached their breaking point and blew the whistle, sparking a sprawling investigation in the government’s fight to hold the drug industry accountable in the spread of addictive opioids. With colourful characters and true suspense, The Hard Sell lays bare the pharma playbook. Evan Hughes offers a bracing look not just at Insys, but at how opioids are sold at the point they first enter the national bloodstream – in the doctor’s office . . .

This collection breaks new ground by investigating applications of degrowth in a range of geographic, practical and theoretical contexts along the food chain. Degrowth challenges growth and advocates for everyday practices that limit socio-metabolic energy and material flows within planetary constraints. As such, the editors intend to map possibilities for food for degrowth to become established as a field of study. International contributors offer a range of examples and possibilities to develop more sustainable, localised, resilient and healthy food systems using degrowth principles of sufficiency, frugal abundance, security, autonomy and conviviality. Chapters are clustered in parts that critically examine food for degrowth in spheres of the household, collectives, networks, and narratives of broader activism and discourses. Themes include broadening and deepening concepts of care in food provisioning and social contexts; critically applying appropriate technologies; appreciating and integrating indigenous perspectives; challenging notions of 'waste', 'circular economies' and commodification; and addressing the ever-present impacts of market logic framed by growth. This book will be of greatest interest to students and scholars of critical food studies, sustainability studies, urban political ecology, geography, environmental studies such as environmental sociology, anthropology, ethnography, ecological economics and urban design and planning.

The Soviet Air Force had just started to re-equip with modern fighters when the Germans opened Operation Barbarossa, the invasion of the Soviet Union. Hundreds of fighters were destroyed in the first few days, but many of these were obsolete biplanes and monoplanes. The remaining fighters, including more modern types such as the MiG-3 and LaGG-3, tried to stem the Nazi advance. This book details the development of the Red Air Force fighters, from the dark days of Operation Barbarossa, to eventual triumph over the ruins of Berlin. Starting with obsolete aircraft such as the Polikarpov biplane and monoplane fighters, the Soviets then settled on two main lines of development; the inline-engined LaGG-3 and its radial-engined derivatives, the La-5 and La-7, and the inline-engined Yakovlev fighters, which were produced in greater numbers than any other series of fighters. Not only are these aircraft described in great detail, but experimental fighters are also dealt with. In addition to the descriptions, accurate colour profiles are provided illustrating the evolution of these aircraft in terms of design, camouflage, and markings. From the fixed undercarriage I-15bis biplane of the beginning of the Great Patriotic War, to the superb La-7 and Yak-3 fighters of the last year of the war, the fighters of the Red Air Force are all covered in this comprehensive book.

Lean is about building and improving stable and predictable systems and processes to deliver to customers high-quality products/services on time by engaging everyone in the organization. Combined with this, organizations need to create an environment of respect for people and continuous learning. It's all about people. People create the product or service, drive innovation, and create systems and processes, and with leadership buy-in and accountability to ensure sustainment with this philosophy, employees will be committed to the organization as they learn and grow personally and professionally. Lean is a term that describes a way of thinking about and managing companies as an enterprise. Becoming Lean requires the following: the continual pursuit to identify and eliminate waste; the establishment of efficient flow of both information and process; and an unwavering top-level commitment. The concept of continuous improvement applies to any process in any industry. Based on the contents of The Lean Practitioners Field Book, the purpose of this series is to show, in detail, how any process can be improved utilizing a combination of tasks and people tools and introduces the BASICS Lean (R) concept. The books are designed for all levels of Lean practitioners and introduces proven tools for analysis and implementation that go beyond the traditional point kaizen event. Each book can be used as a stand-alone volume or used in combination with other titles based on specific needs. Each book is chock-full of case studies and stories from the authors' own experiences in training organizations that have started or are continuing their Lean journey of continuous improvement. Contents include valuable lessons learned and each chapter concludes with questions pertaining to the focus of the chapter. Numerous photographs enrich and illustrate specific tools used in Lean methodology. Implementing Lean: Converting Waste to Profit explores implementation methods, line balancing methods, including baton zone or bumping, and implementing Lean in the office and machine shops. The goal of this book is to introduce the balance of the tools and how to proceed once the analysis is completed. There are many pieces to a Lean implementation and all of them are interconnected. This book walks through the relationships and how the data presented can be leveraged to prepare for the implementation. It also provides suggest solutions for improvements and making recommendations to management to secure their buy-in and approval.

This book explores the superiority of the management systems found in world class Japan manufacturers and the process by which these systems are being imported to the USA. The concept of Japanese manufacturing methods, in particular the system known as "lean production," is transforming American industry. The editors and contributors use the term "Japanese Advanced Manufacturing Systems" to refer to social, organizational, and technological systems used by world class Japanese manufacturers. They look at the system at the factory level, the corporate system level, and at a level outside the corporate system, including consumer markets, the regulatory environment, the technology sector, and the educational system outside the firm. The two industries that are addressed are automobiles and electronics.

Imagine if you were there, taking notes, as a small pizza joint became one of the most successful restaurants in the world. The Domino's Story will help you understand and adopt the competitive strategies, workplace culture, and business practices that made the iconic pizza chain the innovative restaurant and e-commerce leader it is today. As one of the most technologically advanced fast-food chains in the market, Domino's has cemented their reputation for innovation, paved in industry-leading profits. In February 2018, according to Ad Age, Domino's unseated Pizza Hut to become the largest pizza seller worldwide in terms of sales. Rather than just tampering with a recipe that was working, they decided to think outside of the pizza box by creating digital tools that emphasized convenience and put the customer first. For the first time, the adaptable strategies behind the rise and dominance of Domino's are outlined in these pages. Through the story of the Domino's, you'll learn: How to create meaningful innovation without changing the core of the product that people already love. How to recognize and take advantage of unique opportunities to alleviate your customers' pain points. How to grow a company by taking a holistic approach to the business. And, the importance of delivering a quality experience that will keep customers calling for more.

Shipbuilding in the United Kingdom provides a systematic historical account of the British Shipbuilders Corporation, first looking at this major industry under private enterprise, then under state control, and finally back in private hands. The chapters trace the evolution of public policy regarding shipbuilding, ship repair, and large marine engine building through the tenures of radically different Labour and Conservative governments, and through the response of the board of the British Shipbuilders Corporation, trade unions, and local management also. The book benefits from comprehensive archival research and interviews from the 1990s with leading players in the industry, as well as politicians, shipbuilders, trade union leaders, and senior civil servants. This authoritative monograph is a valuable resource for advanced students and researchers across the fields of business history, economic history, industrial history, labour history, maritime history, and British history.

Developing an ISO 13485-Certified Quality Management System: An Implementation Guide for the Medical-Device Industry details the lessons learned from a real-world project focusing on building an ISO 13485:2016 Quality Management System (QMS) from scratch and then having it officially certified. It is a practical guide to building or improving your existing QMS with tried and tested solutions. The book takes a hands-on approach-first teaching the top 25 lessons to know before starting to develop a QMS and then walking you through the process of writing the quality manual and the standard operating procedures, training the staff on the QMS, organizing an internal audit, executing a management review, and finally passing the necessary external audits and obtaining certification. It helps you to progress from one task to the next and provides all the essential information to accomplish each task as quickly and efficiently as possible. It does not attempt to replicate the standard but instead drills into the standard to expose the core of each section of the standard and reorganize its contents into a practical workflow for developing, maintaining, and improving a Lean QMS. The book includes a wealth of real-world experience both from the author's personal dive into quality management, and from the experiences of other companies in the field and provides handy checklists for ensuring key documents and processes are fit for use-the emphasis here is to help ensure you have considered all relevant aspects. In addition, the book is not intended as a "cheat sheet" for the standard or as a review of the standard that only adds lengthy commentary on each of the clauses. Instead, the book fixes easy misunderstandings regarding QMS, provides insight into why the various clauses are written the way they are, and provides a great base to both understanding ISO 13485 QMS and developing your own QMS. The book is intended to serve both experts and novices audiences-it provides special insight on the most crucial and effective aspects of QMS.

This essential book provides the first comprehensive overview of the symbiotic relationship that exists between fashion and textiles. Because textiles represent a central ingredient of fashion (as with denim jeans, for example), their interrelationship should be an obvious theme for study, yet historically the two subjects are often considered separately. Gale and Kaur analyze fashion and textile's cultural, industrial and social relationships, as well as examining how the two fields compete with and influence one another. Taking as their starting point the nature of the relationship between fashion and textiles, Gale and Kaur then identify and discuss key arenas of commercial and cultural interaction, including raw materials, business, consumers, and future technology. Their examples are drawn from the experiences and opinions of industry professionals - designers, retailers, and manufacturers. Gale and Kaur look at how the raw materials from which clothing is made are heavily influenced by fashion trends on national and global levels. Why do we choose the fabrics we do, and how do our choices affect both industries? The story is very much a human one. Each garment has an intriguing history before a consumer even tries it on. Gale and Kaur unpick this history and examine how retail need and consumer demand impact upon the end product. The result is an exciting new book that begins at the level of supply and demand, and moves forward to consider issues about design, technology, globalization and broader fashion trends. Highlighting cultural differences and similarities between the two industry sectors, Fashion and Textiles offers varied professional perspectives, information about key roles and jobs, and practical considerations relating to economics, design, manufacture and retail. A key text for a wide range of courses on fashion and textiles, it is vital reading for anyone hoping to pursue a career in either field.

This book presents applications of blockchain technologies to foster sustainable development in the textile and clothing supply chain. The concept of Textiles and Fashion Sustainability has grown to a wider extent today. Among the list of items to achieve Sustainability in Textiles and Fashion, the key element is the traceability of supply chains in terms of mapping and tracing the entire supply chain to ensure sustainable supply chain management. Reliable and transparent, efficient data is one of the crucial requirements for Textiles and Fashion Sustainability in today's advanced industrial context and this is possible in this advanced era by various technological advancements such as Block chain technologies. These days one can see a widespread application of blockchain technology in the Textiles and Clothing sector. The core competencies of blockchain technology namely transparency, data auditability, privacy, value transfer, and process efficiency and automation are very much essential for achieving the multifold objectives under the theme Textiles and Fashion Sustainability.

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Sixth Edition features the latest research surrounding the application of pharmacology in drug discovery in an effort to equip readers with a deeper understanding of complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for anyone involved in drug discovery. This edition has been reorganized for better flow and clarity and includes material on new technologies for screening (virtual, DNA encoded libraires, fragment-based) and a major section on phenotypic (target agnostic) screening for new leads and determination of drug targets. With full color illustrations as well as new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such a mRNA, gene therapy, antibodies and information on CRISPR and genomics.

Data analytics underpin our modern data-driven economy. This textbook explains the relevance of data analytics at the firm and industry levels, tracing the evolution and key components of the field, and showing how data analytics insights can be leveraged for business results. The first section of the text covers key topics such as data analytics tools, data mining, business intelligence, customer relationship management, and cybersecurity. The chapters then take an industry focus, exploring how data analytics can be used in particular settings to strengthen business decision-making. A range of sectors are examined, including financial services, accounting, marketing, sport, health care, retail, transport, and education. With industry case studies, clear definitions of terminology, and no background knowledge required, this text supports students in gaining a solid understanding of data analytics and its practical applications. PowerPoint slides, a test bank of questions, and an instructor's manual are also provided as online supplements. This will be a valuable text for undergraduate level courses in data analytics, data mining, business intelligence, and related areas.

What do you get when you cross a journalist and a banker? A brewery, of course.

"A great city should have great beer. New York finally has, thanks to Brooklyn. Steve Hindy and Tom Potter provided it. Beer School explains how they did it: their mistakes as well as their triumphs. Steve writes with a journalist's skepticism--as though he has forgotten that he is reporting on himself. Tom is even less forgiving--he's a banker, after all. The inside story reads at times like a cautionary tale, but it is an account of a great and welcome achievement."
--Michael Jackson, The Beer Hunter(R)

"An accessible and insightful case study with terrific insight for aspiring entrepreneurs. And if that's not enough, it is all about beer!"
--Professor Murray Low, Executive Director, Lang Center for Entrepreneurship, Columbia Business School

"Great lessons on what every first-time entrepreneur will experience. Being down the block from the Brooklyn Brewery, I had firsthand witness to their positive impact on our community. I give Steve and Tom's book an A++!"
--Norm Brodsky, Senior Contributing Editor, Inc. magazine

"Beer School is a useful and entertaining book. In essence, this is the story of starting a beer business from scratch in New York City. The product is one readers can relate to, and the market is as tough as they get. What a fun challenge! The book can help not only those entrepreneurs who are starting a business but also those trying to grow one once it is established. Steve and Tom write with enthusiasm and insight about building their business. It is clear that they learned a lot along the way. Readers can learn from these lessons too."
--Michael Preston, Adjunct Professor, Lang Center for Entrepreneurship, Columbia Business School, and coauthor, The Road to Success: How to Manage Growth

"Although we (thankfully!) never had to deal with the Mob, being held up at gunpoint, or having our beer and equipment ripped off, we definitely identified with the challenges faced in those early days of cobbling a brewery together. The revealing story Steve and Tom tell about two partners entering a business out of passion, in an industry they knew little about, being seriously undercapitalized, with an overly naive business plan, and their ultimate success, is an inspiring tale."
--Ken Grossman, founder, Sierra Nevada Brewing Co.

This study is about the struggle for survival among the assembler and components firms which constitute the European automobile industry. The book describes and explains the competitive, structural, organizational and technological changes being made and outlines the spatial and economic effects of these changes. The empirical core of the book is a study of the number of technology fields in automobile components. These sections draw on up-to-date research carried out by the authors in Europe, through which they evaluate the extent to which lean production techniques have permeated the assemblers and components industry.

This book provides an understanding of innovation models and why they are important in the business context, and considers sources of innovation and how to apply business frameworks using real-world examples of innovation-led businesses. After providing a solid background to the key concepts related to innovation models, the book looks at why innovation takes place and where the sources of innovation lie, from corporate research to crowd-sourced and government-funded initiatives. Innovation models across manufacturing, services and government are explored, as well as measuring innovation, and the impact of design thinking and lean enterprise principles on innovation and sustainability-driven imperatives. Offering a truly comprehensive and global approach, Business Innovation should be core or recommended reading for advanced undergraduate, postgraduate, MBA and Executive Education students studying Innovation Management, Strategic Management and Entrepreneurship.

Chevrolet was Number One in the sales race. If you needed a car, chances are Chevrolet made it. However, in 1964 there arose a problem. Some guy at Ford came up with a car called the Mustang, maybe you've heard of it? But don't worry, Chevrolet had a solution called the Camaro. In racing, where you are on lap one, isn't nearly as important as your position when the checkered flag falls. By 1981, Camaro was so far in front of Mustang, Henry needed binoculars to see the Z28's taillights! Camaro was part of the speed shop scene, modified by the most famous names of the muscle car era. In racing, Chevrolet's pony left no stone unturned, inside and outside America. With the fuel crisis, insurance, and inflation, America sought a new kind of coupe. The Bowtie boys even outsold Mustang, with that Z28 having the upper hand in the Chevrolet versus Ford rivalry. Chevrolet's dedicated coupe even outfoxed Ford's sedan based Mustang. If the Corvette is the King of American Sportscars, then 'The Hugger' must be the Prince of Ponies!

The history of cut nail manufacturing shows how the interaction of technology and markets shaped the structure, organizational patterns, management systems, and individual production units of a single industry--a classic example of the American enterprise system at work. Reliance on wood construction created an expanding market for cut nails and exerted considerable pressure for high volume and low prices. Industry responded to this challenge, introducing and perfecting machine-made nails. As this competitive advantage began to decline the industry was again transformed by management changes and the implementation of cost accounting. Loveday utilizes the records of four dominant companies in the industry and journalistic accounts to document the complex patterns of growth and decline, innovation and obsolescence in the cut nail industry.