In terms of commercialization, nanomaterials occupy a unique place in nanotechnology. Engineered nanomaterials, especially nanoparticulate materials, are the leading sector in nanotechnology commercialization. In addition, the nanomaterial sector has attracted much more heated debate than any other nanotechnology sector with regard to safety, regulation, standardization, and ethics. This is the first book on nanotechnology commercialization that deals exclusively with nanomaterials. It provides overviews of the current trends in, and the issues associated with, the commercialization of nanomaterials by some of the foremost nanotechnology experts in their fields.

Sand, Planes and Submarines is an unlikely title for a book about the role two small towns far from the sea played in the First World War. Yet this extraordinary account tells how Leighton Buzzard and Linslade provided the means to shorten the war. Without the sand, the big guns could not have been made for the Front; the planes allowed the Royal Flying Corps to take on the superior German air force; and the submarine nets protected not only the British fleet but also the French, Italians, Americans and Russians. The two towns were changed dramatically by the war. They ceased to be the playground of the rich from London. The army requisitioned the hundreds of thoroughbred horses that had been used by the aristocracy to hunt with the Rothschilds. Among these larger themes there are many personal stories like that of the Linslade postman and his horse, Bluebell, who took part in the last great cavalry charge of the war.

The book arose from a multi-disciplinary study which looked at the development of global-local manufacturing clusters in the context of a developing, Asian economy. The study demonstrates the connection amongst theoretical perspectives such as international business, development studies, economic geography, and organisational learning clusters/production networks through an in-depth case study of the Indonesian automotive cluster. The book gives a detailed account of two automotive clusters (Toyota and Honda) and their contribution to regional economic development in emerging economies in Asian region. The book builds on existing literature to develop a theoretical framework to shed light on the study's empirical findings. The book discusses practical implications for both the business community and policy makers. The discussion on global-local networks in an Asian context supplements existing literature and case studies in the field. This is one of the few books that explicitly links regional clusters to global networks. The book offers a refreshingly international (Asian) perspective to the literature on clusters and economic geography for emerging economies.

In Transforming Big Pharma John Ansell addresses critically how strategy works in the pharmaceutical industry. The long-standing dearth of new products has led to a growing shortfall in revenues. Ansell assesses the wide range of alternative strategies big pharma companies have been pursuing in recent years in attempting to overcome this. He shows that there is sound evidence to expect the recent upturn in the number of new products reaching the market to go on to greater heights. Chapters assess the complex trends in attrition rates, show how rife spectacular sales underestimation in the industry remains, and explain how conventional wisdom on the chances of product profitability also seriously undersells the industry. The surest route to transforming the prospects for big pharma, Ansell contends, is to step up activity in acquiring and developing new products. This is now realistic because, as he shows, the amount of intellectual property available is much greater than it was a decade ago. Ansell believes that no other strategies have sufficient transformative powers, though they may be useful as a stopgap whilst the sales of forthcoming new products mature. He argues for a reversal of big pharma's recent cutbacks in R&D and licensing, and re-focussing on new product development. Transforming Big Pharma is intended for those in senior and middle management in the pharmaceutical industry. It will also be valuable to students, as well as to all those dealing with the industry, including biotech companies and those providing services and products to the pharmaceutical industry.

This reference text discusses fundamentals, classification, principles, applications of additive and subtractive manufacturing processes in a single volume. The text discusses 3D printing techniques with the help of practical case studies, covers rapid tooling using microwave sintering and ultrasonic assisted sintering process, and covers different hybrid manufacturing techniques like cryo-MQL, and textured cutting inserts. It covers important topics including green manufacturing, ultrasonic assisted machining, electro thermal based non-conventional machining processes, metal based additive manufacturing, LASER based additive manufacturing, indirect rapid tooling, and polymer based additive manufacturing. The book: Discusses additive and subtractive manufacturing processes in detail Covers hybrid manufacturing processes Provides life cycle analysis of conventional machining Discusses biomedical and industrial applications of additive manufacturing The text will be useful for senior undergraduate, graduate students, and academic researchers in areas including industrial and manufacturing engineering, mechanical engineering, and production engineering. Discussing the sustainability aspects of conventional machining in reducing carbon footprint of machining by adopting different hybrid and non-conventional machining processes, this text will be useful for senior undergraduate, graduate students, and academic researchers in areas including industrial and manufacturing engineering, mechanical engineering, and production engineering.

After the end of hostilities in 1945, the fishing industry was quick to establish some semblance of recovery and a surge of new builds and restoration of Admiralty motor fishing vessels soon followed. In Fraserburgh, on Scotland's east coast, several established yards satiated this desire amongst the fishing-boat owners for new craft. Thus it wasn't surprising that a new yard sprung up at the end of the 1940s when three local apprentices from one of the yards decided to set up their own boatbuilding yard on the breakwater, in what was a very exposed position. And so the yard of Thomas Summers & Co. was born, a yard that became synonymous with fine seaworthy fishing boats suited to various methods of fishing. In the space of just thirteen years they produced eighty-eight fishing vessels and their output was more prolific than most of the other Scottish boatyards. Many of these boats survive to this day, some still working as fishing vessels, and others converted to pleasure, a testament to their superb design and solid construction. Here, Mike Smylie recounts the story of Thomas Summers & Co. through historic records and personal memories of both fishermen and family members, with many striking photographs of the boats they built.

This is the first book to present marketing strategy of high-tech products and services in a legal, economic, and global context. From software to hardware, from pharmaceuticals to digital movies and TV, the authors argue that the understanding of intellectual property rights (IPRs) is essential to devising effective marketing strategies.

This practical guide covers the steps necessary to sustain quality in a project from start to finish. The book shows how to identify risks at different processes, phases, and stages and offers directions on how to mitigate and reduce risks using analysis, evaluation, and monitoring. Risk Management Applications Used to Sustain Quality in Projects: A Practical Guide focuses on applying risk management principles to manage quality in all project management processes, stages, and phases. The book discusses the potential risks that may occur at the different phases of the project life cycle, their effects on projects, and how to prevent them. It explores all the process elements and activities of risk management and provides steps on how to make the project more qualitative, competitive, and economical. Risk management processes are discussed at each project management processes and project lifecycle phase/stage to help the reader understand how various risks can occur and how to mitigate and reduce them. The main audience for this book is project management professionals, quality managers, systems engineers, construction managers, and risk management professionals as well as industrial engineers, academics, and students.

China is flexing its growing military and strategic clout in the pursuit of broadening national security interests. At the same time, the country's economic and technology policies have also become more nationalistic, state-centered, and ambitious. China's defense economy has set its sights on catching up with the West by the beginning of the 2020s and is making steady progress in building up its innovation capabilities, although this is presently in the form of incremental and sustaining types of activities. More high-end, disruptive forms of innovation that would lead to major breakthroughs are likely to be beyond China's reach in the near-to medium term. This volume provides a wide-ranging and detailed assessment of the present state of the Chinese defense economy at a time of rapid change and accelerating advancement in its innovation capabilities and performance. This collection of articles has three main goals: (1) to locate China's defense innovation dynamics within broader historical, technological and methodological frameworks of analysis; (2) to assess the performance of the Chinese defense economy's six principal subsectors; and (3) to compare China's approach to defense industrialization with major counterparts in the Asia-Pacific region. This book was originally published as a special issue of the Journal of Strategic Studies.

In 14 original essays, The Oxford Illustrated History of the Book reveals the history of books in all their various forms, from the ancient world to the digital present. Leading international scholars offer an original and richly illustrated narrative that is global in scope. The history of the book is the history of millions of written, printed, and illustrated texts, their manufacture, distribution, and reception. Here are different types of production, from clay tablets to scrolls, from inscribed codices to printed books, pamphlets, magazines, and newspapers, from written parchment to digital texts. The history of the book is a history of different methods of circulation and dissemination, all dependent on innovations in transport, from coastal and transoceanic shipping to roads, trains, planes and the internet. It is a history of different modes of reading and reception, from learned debate and individual study to public instruction and entertainment. It is a history of manufacture, craftsmanship, dissemination, reading and debate. Yet the history of books is not simply a question of material form, nor indeed of the history of reading and reception. The larger question is of the effect of textual production, distribution and reception - of how books themselves made history. To this end, each chapter of this volume, succinctly bounded by period and geography, offers incisive and stimulating insights into the relationship between books and the story of their times.

In Future Luxe: What's Ahead for the Business of Luxury, Erwan Rambourg identifies the major forces and emerging trends that are set to reshape luxury over the next decade. The expansion of Chinese consumption and the boost in women's spending power around the world will fuel continued growth in the industry-but even more importantly, fundamental changes are on the horizon. The younger generation is entering the luxury market, bringing new values and demands that will redefine the very meaning of luxury. The sector should expand in the realms of travel, health, leisure, even cannabis. For brands to resonate with these younger consumers they will have to develop substance beyond a high-quality product or a desirable logo. Greenwashing won't cut it-brands will need to take seriously issues like diversity, sustainability, and ethical production. To ensure his portrait of the industry has the depth and nuance of real-world experience, Rambourg interviews several CEOs from the largest groups and brands, including Kering, Cartier, Puma, and Moncler, in addition to drawing on his own observations from over two decades in luxury. Future Luxe is engaging, wise, and deeply informed, a vital read for those new to the industry as well as veterans planning for continued success.

Discusses the valorization of fruit processing by-products Covers the role of the byproducts as prebiotics and dietary fibers Presents extraction techniques of bioactive compounds from fruit wastes

This book examines the political economy of attempts to restructure the Donbass, one of the Soviet Union's most important 'old economy' 'rustbelt' industrial regions. It shows how local interest groups have successfully frustrated the central government's and the World Bank's proposed market-oriented restructuring, and how a manufacturing-based regional economy is surviving, partially, with restructuring postponed.

For those of advanced tastes, the Modern Movement was a welcome corrective to the debased aesthetics of the commercial world. The products of light industry were as untutored in the 1920s and 30s as massed housing and both took scant interest in the idealist thinking that sought to harness architecture and design to social progress. Robert Best, one of Britain’s leading industrialists in this period, shared the goal of better mass education but was troubled by Modernism’s promoters, for reasons that they found hard to understand. If the few knew better than the many, and had an obligation to elevate them whether they liked it or not, where did this leave the democratic principles that our liberal society prided itself on? Best felt that the campaign to popularise Functionalist design took propaganda into territory that had uncomfortable political overtones. In this extraordinary memoir, written in the early 1950s but never previously published, Best explored his concern about the sense of noblesse oblige that lay behind such bodies as the Council of Industrial Design, set up in 1944 ostensibly to raise the saleability and quality of British manufacturing but also, in his view, to brainwash the public into denying what it liked in favour of more cultivated but untested alternatives.

This title includes a number of Open Access chapters. Pharmaceutical technology deals with the discovery, production, processing, and safe and effective delivery of medications to patients. Technologies involved include computer modeling for research, bioengineering for research instrumentation, processes and methods for increasing production, and computing technology and biosystematics for the management and analysis of data. This new book covers a wide range of important topics on today's pharmaceutical technology, such as in vitro drug release and controlled drug delivery, the use of nanotechnology in pharmaceuticals, quantum dot imaging, assessment and efficacy of pharmaceuticals, and much more.

The rapid changes taking place in the structure and governance of national and regional agri-food markets in developing countries seriously affect the ability of agriculture, especially small-scale agriculture, to contribute to economic growth and sustainable development. Reconnecting Markets is the second volume of case examples from the Regoverning Markets programme (2005-2008). It focuses on the keys to inclusion of small-scale farmers and rural SMEs into dynamic national and regional markets. The cases document specific arrangements that appear to have played a positive role in supporting greater inclusion, such as public policies and business initiatives, collective action by farmers and support from development agencies.

Compaction of powder constituents-both active ingredient and excipients-is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application. This unique reference covers: The physical structure of pharmaceutical compacts Bonding phenomena that occur during powder compaction Compression mechanisms of pharmaceutical particles Theories and basic principles of powder compaction New topics include: Compaction data analysis techniques The migration of powder constituents into commercial manufacture Instrumentation for compaction Compaction functionality testing, which is likely to become a USP requirement Design space for compaction Metrics required for scalability in tablet compression Interactive compaction and preformulation database for commonly used excipients

Written by actual Toyota team members, One Team on All Levels: Stories from Toyota Team Members, Second Edition is not another technical explanation of the Toyota Production System (TPS). Rather, it illustrates the culture it creates. The stories, told by employees from various levels of the organization, illustrate how Toyota's presence in Kentucky has transformed the professional and personal lives of those who worked for the company. Demonstrates the culture created by the Toyota Production System Examines how the TPS principles and precepts serve as models for servant leadership Presents valuable insights from a wide range of Toyota team members-from hourly to management-level Shows how Toyota partnered with the city of Georgetown and its community Supplying a first-hand look at the principles that have transformed Toyota into one of the leading manufacturers in the world, the book includes chapters that address how this manufacturing giant was able to survive and improve in the midst of a down economy and recent recalls. The real-life stories supply an unprecedented look at how the Toyota precepts and the fourteen Toyota Way principles can help you improve morale, avoid layoffs, and create a culture of continuous improvement within your organization.

First published in 1965. This study was initially carried out in the years 1934 to 1937, with completion during 1939 at the outbreak of war which deferred publication. This second edition includes an extra appendix on the report of 'Clothing Committee of the Privy Council' dated 22 June 1622 and more background on the seventeenth and sixteenth centuries.

By any standard, the pharmaceutical industry's history has been a successful one. In addition to its profits and shareholder dividends, it has been seen by investors as relatively low risk and, largely, counter-cyclical to stock market trends. However, that important contribution appears to be petering out, with significant global implications for employees, shareholders, governments and patients. This is not just caused by the economic crisis. Long before this, several distinct but related streams of evidence emerged that now point to the stalling of the pharmaceutical industry. The Future of Pharma examines the causes of the industry's potential decline and offers a convincing and rigorous analysis of the options open to it. What emerges is a landscape defined, on the one hand, by the changing marketplace of mass-market consumers, institutional healthcare systems and wealthy individuals; and on the other by the alternate sources of commercial value - innovative therapies; super-efficient processes, supply chains and operations; and closer customer relations and increasingly tailored health services. The challenges to the pharmaceutical industry now and in the medium and long-term are very significant. Brian Smith's highly readable research findings are a wake-up call and a first step forward for anyone concerned with the future of the industry; whether executive, customer, policymaker or investor.

PRESCRIPTION DRUGS ARE THE THIRD LEADING CAUSE OF DEATH AFTER HEART DISEASE AND CANCER. In his latest ground-breaking book, Peter C Gotzsche exposes the pharmaceutical industries and their charade of fraudulent behaviour, both in research and marketing where the morally repugnant disregard for human lives is the norm. He convincingly draws close comparisons with the tobacco conglomerates, revealing the extraordinary truth behind efforts to confuse and distract the public and their politicians. The book addresses, in evidence-based detail, an extraordinary system failure caused by widespread crime, corruption, bribery and impotent drug regulation in need of radical reforms. "The main reason we take so many drugs is that drug companies don't sell drugs, they sell lies about drugs. This is what makes drugs so different from anything else in life...Virtually everything we know about drugs is what the companies have chosen to tell us and our doctors...the reason patients trust their medicine is that they extrapolate the trust they have in their doctors into the medicines they prescribe. The patients don't realise that, although their doctors may know a lot about diseases and human physiology and psychology, they know very, very little about drugs that hasn't been carefully concocted and dressed up by the drug industry...If you don't think the system is out of control, please email me and explain why drugs are the third leading cause of death...If such a hugely lethal epidemic had been caused by a new bacterium or a virus, or even one-hundredth of it, we would have done everything we could to get it under control." FROM THE INTRODUCTION

This three-volume set of Pharmaceutical Dosage Forms: Parenteral Medications is an authoritative, comprehensive reference work on the formulation and manufacture of parenteral dosage forms, effectively balancing theoretical considerations with the practical aspects of their development. As such, it is recommended for scientists and engineers in the pharmaceutical industry and academia, and will also serve as an excellent reference and training tool for regulatory scientists and quality assurance professionals. First published in 1984 (as two volumes) and then last revised in 1993 (when it grew to three volumes), this latest revision will address the plethora of changes in the science and considerable advances in the technology associated with these products and routes of administration. The third edition of this book maintains the features that made the last edition so popular but comprises several brand new chapters, revisions to all other chapters, as well as high quality illustrations. Volume two presents: * Chapters on aseptic facility design, environmental monitoring, and cleanroom operations. * A comprehensive chapter on pharmaceutical water systems. * A discussion of quality attributes of sterile dosage forms, including particulate matter, endotoxin, and sterility testing. * A detailed chapter on processing of parenteral drug products (SVPs and LVPs). * Presentations on widely used sterilization technologies - steam, gas / chemical, radiation, filtration and dry heat. * An in-depth chapter on lyophilization.

This book explores why Japan, despite being a world leader in many high technology industries such as automobiles and consumer electronics, is only a minor player in the global pharmaceutical industry. Japan provides a huge market for pharmaceuticals as the second largest consumer of prescription drugs after the United States, and is a massive importer of prescription drugs, relying on discoveries made elsewhere. This book charts the development of the industry, from the devastation resulting from the Second World War to its performance in the present day. Focusing in particular on antibiotics and anticancer drugs, the book analyses factors that have prevented Japan from leading the rapid advances in science and technology that have occurred globally over recent decades. Looking at the pharmaceutical industry, the book argues that the Japanese government's research and development policies were not sufficiently incentivising. It also shows how the nature of capitalism in Japan - which featured close relations between government and industry as well as between and within firms - was appropriate for nurturing industrial development in the immediate post-war decades, but became much less effective in later years.

Retail is 'going digital,' and grocery shopping is no exception. While some businesses are relaying on their corporate website to make the sale, both traditional brick-and-mortar and new disruptive business models are increasingly using online marketplaces to offer their products online. European Union law has been gradually updated to reflect this new reality, with Intellectual Property Rights legislation and Consumer Law leading the way toward a suitable regulatory framework in the Platform Economy. However, the EU has not devised a comprehensive strategy for tackling the challenges posed by the online sale of physical consumer goods, such as effective public enforcement in online environments. In fact, sector-specific legislation, including Food Law, largely ignores online transactions. In this context, the book evaluates the impact that online marketplaces are having on European Union sector-specific legislation and its e-nforcement. The goal is to assess whether the existing regulatory and policy framework are sufficient for promoting compliance and bridging the enforcement gap in the digital single market. Focusing on the e-food market, the book presents a state-of-the-art overview of how online marketplaces are altering EU law and its enforcement by public authorities.