Drug-related morbidity and mortality is rampant in contemporary industrial society, despite or perhaps because, government has assumed a critical role in the process by which drugs are developed and approved. Parrish asserts that, as a people, Americans need to understand how it is that government became the arbiter of pharmaceutical fact. The consequences of our failure to understand, he argues, may threaten individual choice and forestall the development of responsible therapeutics. Moreover, if current standards and control continues unabated, the next therapeutic reformation might well make possible the sanctioned commercial exploitation of patients. In "Defining Drugs," Parrish argues that the federal government became arbiter of pharmaceutical fact because the professions of pharmacy and medicine, as well as the pharmaceutical industry, could enforce these definitions and standards only through police powers reserved to government. Parrish begins his provocative study by examining the development of the social system for regulating drug therapy in the United States. He reviews the standards that were negotiated, and the tensions of the period between Progressivism and the New Deal that gave cultural context and historical meaning to drug use in American society. Parrish describes issues related to the development of narcotics policy through education and legislation facilitated by James Beal and Edward Kremers, and documents the federal government's evolving role as arbiter of market tensions between pharmaceutical producers, government officials, and private citizens in professional groups, illustrating the influence of government in writing enforceable standards for pharmaceutical therapies. He shows how the expansion of political rights for practitioners and producers has shifted responsibility for therapeutic consequences from individual practitioners and patients to government. This timely and controversial volume is written for the scholar and the compassionate practitioner alike, and a general public concerned with pharmacy regulation in a free society. Richard Henry Parrish II is assistant professor of pharmacy practice at the Bernard J. Dunn School of Pharmacy at Shenandoah University. "Defining Drugs documents the evolution of social thought and action about pharmaceuticals in the United States in the 20th century. Written from a free-market perspective, Richard Parrish demonstrates how industry, goverment, and profressional leaders used science to justify the expansion of goverment power over standards and people. The Politicized definition of pharmaceutical fact cemented the foundation of pharmacotherapy in the modern pharmacratic state. Parrish's thesis will affect the current debates on federal power concerning the proper role of pharmacists, physicians, prescription laws, and Medicare prescription benefits; dietary supplements and herbal remedies; and nanotechnologies and pharmacgenomics. Scholary in documentation and persuasive in tone, "Defining Drugs" is an indispensable contribution to our understanding of the debate about drugs and drug policy." --Dr. Thomas Szasz, State University of New York "Parrish provides an invaluable analysis of the transformation of pharmaceutical regulation over the past millennium."--Peter Barton Hutt, Esq., Covington and Burling ""Defining Drugs" is an essential key for the medical profession and any who would understand the drug industry's regulation processes." uThe Midwest Book Review

Challenged by stringent regulations, vigorous competition, and liability lawsuits, medical device manufactures must develop safe, reliable, and cost-effective products, and managing and reducing risk is a vital element of reaching that goal. These guidelines focus on Failure Modes and Effects Analysis (FMEA) and its application throughout the life cycle of a medical device. It outlines the major U.S. and E.U. standards and regulations and provides a detailed yet easy-to-read overview of risk management and risk analysis methodologies, common FMEA pitfalls, and FMECA-Failure Mode, Effects, and Criticality Analysis.

Guidelines for Failure Modes and Effects Analysis for Medical Devices is written as a practical guide to achieving corporate consistency while dramatically cutting the time required for studies. It will help you prevent patient injuries, costly product recalls, and production department down-time.

Discover how the FMEA methodology can help your company achieve a more cost-effective manufacturing process by improving the quality and reliability of your products. This new FMEA manual from the experts at Dyadem is the ultimate resource for you and your colleagues to learn more about Failure Modes and Effects Analysis and then teach others at your facility. This comprehensive manual is sure to become a standard reference for engineering professionals.

This third of the three volume series highlights the intricate relationship in the handloom industry between its culture and the various areas of sustainability. While there have been major disruptions in this age old industry, this volume presents the design, development and environmental aspects to keep the industry moving ahead. The book contains seven chapters written by leading experts in the areas and discusses means to revive some of the cultures that are on the verge of closing/shutting down.

The control and organisation of the flow of goods in the supply chain is of vital importance to industry and commerce, including manufacturing industrial enterprises, where the timely and efficient delivery of their output at an economic cost is of great concern. This book considers the out-bound supply chain and the associated out-bound logistics ie the flow of goods from the point of production or manufacture to the point of consumption. In doing so, it has to cover a range of management topics and techniques, including measures of performance, order management and forecasting, stock management and management of the supply chain. Written in clear and jargon-free language, this book, whilst intended primarily students of engineering and manufacturing, at 3rd year undergraduate and postgraduate level, would also be of interest to logistics and operations management students. Typical examination questions are included.

Featuring extensive calculations and examples, this reference discusses theoretical and practical aspects of short-circuit currents in ac and dc systems, load flow, and harmonic analyses to provide a sound knowledge base for modern computer-based studies that can be utilized in real-world applications. Presenting more than 2300 figures, tables, and equations, the author explores matrix methods for network solutions and includes load flow and optimization techniques. He discusses ac and dc short-circuit systems calculations in accordance with standards set by the American National Standards Institute (ANSI) and the International Electrotechnical Commission (IEC).

Food Safety in the Hospitality Industry is a user-friendly guide to current food safety and hygiene legislation and is vital reading for all those involved in food handling and preparation.
Using frequent practical examples, the text outlines and explains what you need to know about the following areas:
-The key legislation and legal background in easy-to-follow terms - includes a comparison of the UK and European Union.
-Safe food handling in practice - an easy reference source for all areas of a catering operation, including food service and labelling, storage and temperature controls and health and safety.
-The application of food safety policies in business - practical guidance on food hazard analysis, including planning, implementation, control and measurement.
Ideal reading for the core food safety component of hospitality management and catering degrees, the text is also a useful reference for industry practitioners who need to be up to speed on the legal requirements and best practice for maintaining safety and hygiene in the workplace.
Provides a framework around which all sectors of industry can build a food hygiene system
Covers the essential legal requirements and background
A practical, comprehensive breakdown of safe food handling practices and application of food safety policies

This book provides extensive insights and analysis into pricing models for autonomous manufacturing. Taking a cost engineering approach, it shows how businesses facing technological change can provide visibility to pricing sensitivity and maximize price, and profit in every transaction. The book pulls together the many elements of cost engineering; cost estimation, cost control, business planning and management, profitability analysis, cost risk analysis and project management, planning, and scheduling, and considers the many different approaches and methods for estimating or assessing costs. It aims to help companies with decision making, cost management, and budgeting with respect to product development, and highlights the importance of cost estimation during the early stages of product development. A discussion of appropriate pricing models is also included to determine the most effective course for handling operational costs in autonomous manufacturing systems in order to create a more productive and profitable system. Cost Engineering and Pricing in Autonomous Manufacturing Systems will provide new insights for researchers and students, as well as industrial practitioners interested in applied models which can be employed and implemented in real cases.

Praise for the previous edition: "[A] fascinating book." John Thackara, Doors of Perception "Provides the foundations for a radical new perspective." Ethical Pulse "At last a book that dispels the idea that fashion is only interested in trend-driven fluff: not only does it have a brain, but it could be a sustainable one." Lucy Siegle, Crafts Magazine Fully revised and updated, the second edition of Sustainable Fashion and Textiles: Design Journeys continues to define the field of design in fashion and textiles. Arranged in two sections, the first four chapters represent key stages of the lifecycle: material cultivation/extraction, production, use and disposal. The remaining four chapters explore design approaches for altering the scale and nature of consumption, including service design, localism, speed and user involvement. While each chapter is complete in and of itself, their real value comes from what they represent together: innovative ways of thinking about textiles and garments based on sustainability values and an interconnected approach to design. Including a new preface, updated content and a new conclusion reflecting and critiquing developments in the field, as well as discussing future developments, the second edition promises to provide further impetus for future change, sealing Sustainable Fashion and Textiles: Design Journeys as the must-buy book for fashion and textiles professionals and students interested in sustainability.

Handley Page began manufacturing aeroplanes in a small factory in Barking, Essex in 1909. Handley Page Limited was founded by Frederick Handley Page (later Sir Frederick) as the United Kingdom's first publicly traded aircraft manufacturing company. Sir Frederick declined to allow his company to be merged into the two large 'forced marriages' of aircraft manufacturing companies in the 1960s. It failed to survive alone, and went into voluntary liquidation and ceased to exist in 1970. During the First World War Handley Page produced a series of heavy bombers for the Royal Navy to bomb the German Zeppelin yards, with the ultimate intent of bombing Berlin in revenge for the Zeppelin attacks on London. Handley Page had been asked by the Admiralty to produce a "bloody paralyser of an aeroplane". These aircraft included the O/100 of 1915, the O/400 of 1918 and the four-engined V/1500 with the range to reach Berlin. The V/1500 only just reached operational service as the war ended in 1918. The real success of the Company came during the Second World War with the magnificent and robust Halifax bomber. In all, more than 6,000 of them were produced, or more than 40 per cent of Britain's total heavy-bomber power. In the bombing operations alone, approximately 76,000 sorties were flown and nearly a quarter of a million tons of bombs were dropped on to enemy targets. Bomber Command had no less than seventy-six Halifax squadrons in action at the time of its peak strength.

"...A Serf's Journal is a powerful and much-needed overdue call for solidarity today." Alfie Bown, Hong Kong Review of Books Recalling the JeffBoat incident of 2001, A Serf's Journal is Terry Tapp's formidable first-hand account of American workers as they fight a multinational company and their corrupt union to stage the longest wildcat strike in US history.

Cockpit Displays is an in-depth examination of the design rationales, test philosophy and test procedures for cockpit systems. Whilst its main emphasis is on cockpit displays, it also includes an important discussion of flight management systems and mission computers. Areas covered include: the cockpit design process, test techniques for flight displays and equipment, and situation awareness testing. Comparing civil and military requirements, it is an important analysis of the lessons learned from test and evaluation and will be of interest to cockpit systems design engineering staff at major airframe manufacturers, procurement executives and program managers at military aircraft program offices and flight test engineers and test pilots.

Modern biotechnology - the controversial manipulation of genes in living organisms - has far-reaching implications for agriculture, human health, trade and the environment. Against the odds, an international treaty governing biosafety and trade in biotechnology was adopted in 2000. The Cartagena Protocol on Biosafety of the Convention on Biological Diversity deals with one of the most important and challenging issues thrown up by developments in biotechnology. This volume is a comprehensive review of the protocol and the process that led to its adoption. It includes contributions from many of the key players involved and analyses the commercial and political interests at stake, the operations and implications of the protocol, and prospects for the future.

In order to facilitate the safe, efficient and cost effective exchange of passengers and cargo between ground and sky airports require the provision of adequate runways, aircraft manoeuvring areas, cargo sheds and passenger processing facilities. Airports are capital intensive facilities and planning errors which result in the over or under-provision of capacity are both costly and problematic to rectify and so understanding the optimal configuration of passenger terminals is paramount. Of course, the design of passenger terminal buildings is influenced not only by levels of demand, the commercial requirements of airlines and tenant companies, the availability of investment funds and political influence but also by the aircraft that will be using the facility both now and in the future. Indeed, the introduction of the first generation of passenger jets in the 1950s and higher-capacity wide-bodied aircraft in the late 1960s required not only the expansion of gate areas and passenger processing facilities but also the introduction of new technologies such as the travelator, the baggage reclaim carousel and the airbridge. The introduction of the A380 'Super Jumbo' into revenue passenger service in 2007 similarly demanded a reconfiguration of the airports it serves and practitioners need to be cognisant of the options for accommodating a new generation of large aircraft. While large aircraft generally require a lengthy turn around period between flights and the extensive provision of expensive fixed ground support infrastructure, low cost carriers pursue a business model based on very short turnarounds and minimal use of airport infrastructure assets such as airbridges. One of the main challenges facing airport operators is how to accommodate the diverse and dynamic requirements of different operators and these issues are addressed in this Volume. Traditionally, aircraft were made and manufactured by small companies within one country but as costs have increased and technology has become more sophisticated, a relatively small number of manufacturers, which are supported by international supply chains, have come to dominate the commercial aircraft market. Originally, all aviation jet fuels were derived from crude oil. However, concerns about future oil supply and energy security combined with the need to improve aviation's environmental performance and sustainability has driven the development of alternative fuel sources. However, the development and adoption of alternative aviation fuels is not straightforward and the Volume examines the opportunities and challenges of widespread biofuel adoption in terms of production capacity, emissions reductions, cost and commercial viability. The final essays in this Volume address business model innovation in the airline and airport sector and include considerations of the future evolution of low cost carriers, the potential for airline-airport alliances and the development of multi-airport multinational operating companies.

Freeze Drying of Pharmaceutical Products provides an overview of the most recent and cutting-edge developments and technologies in the field, focusing on formulation developments and process monitoring and considering new technologies for process development. This book contains case studies from freeze dryer manufacturers and pharmaceutical companies for readers in industry and academia. It was contributed to by lyophilization experts to create a detailed analysis of the subject matter, organically presenting recent advancements in freeze-drying research and technology. It discusses formulation design, process optimization and control, new PAT-monitoring tools, multivariate image analysis, process scale-down and development using small-scale freeze-dryers, use of CFD for equipment design, and development of continuous processes. This book is for industry professionals, including chemical engineers and pharmaceutical scientists.

The U.S. economy is generally considered to run on free market or laissez faire principles, implying that U.S. policy makers do not provide government support for industrial or commercial sectors. While mostly true, it is not the case with strategic industries, such as aerospace. Support for the aerospace sector has been viewed as essential, because aerospace technologies have been the material backbone of U.S. security systems. But American historic dominance in commercial aerospace, and particularly the large commercial aircraft sector, arose on the back of defence technology paid for by the US government. Aerospace Strategic Trade analyses the subsidy of the U.S. large commercial aircraft (LCA) industry and redefines the terms of the Airbus/Boeing subsidy debate. This is achieved by tracking the benefits to Boeing, of the Research and Technology contracts granted by the DoD and NASA. The book is characterized by a new level of methodological precision in the database upon which the factual claims rest and the analysis derives from an exhaustive search of U.S. public databases and also data on federal R&D contracts, obtained under the Freedom of Information Act (FOIA) in the USA. The overall analysis brings together these two approaches and provides a balanced and highly informative account of U.S. federal funding of the American large commercial aircraft sector. This book is of interest to academics, industrialists and government officials concerned with the aerospace industry, to managers and executives in the aerospace industry.

This book focuses on the development and trends of Chinese local luxury industry in the digital era, which brings a new round of manufacturing transformation and upgrading, as well as development opportunities. It reveals the connotation and mechanism of the new local luxury brands in China step by step by answering the questions of "what, why and how". Through the analysis of 200 + questionnaires by SPSS statistical tools and case study, the book concludes the internal mechanism and theoretical support for China to cultivate new local luxury brands. It presents an overview on the current China's local luxury industry.

This volume explores the interconnection of social, political, technological and economic challenges that impact consumer relationships, new product launches and consumer interests. Featuring contributions presented at the 2019 Academy of Marketing Science (AMS) World Marketing Congress (WMC) held in Edinburgh, Scotland, the theme of this proceedings draws from the Scottish Enlightenment movement of the mid-Eighteenth Century, which centered on ideas of liberty, progress and the scientific method. The core values of this movement are being challenged by the rapidly changing, globally shifting and digitally connected world. The contributions presented in this volume reflect and reframe the roles of marketers and marketing in incorporating and advancing the ideas of the Scottish Enlightenment within contemporary marketing theory and practice. Founded in 1971, the Academy of Marketing Science is an international organization dedicated to promoting timely explorations of phenomena related to the science of marketing in theory, research, and practice. Among its services to members and the community at large, the Academy offers conferences, congresses, and symposia that attract delegates from around the world. Presentations from these events are published in this Proceedings series, which offers a comprehensive archive of volumes reflecting the evolution of the field. The series deliver cutting-edge research and insights, complementing the Academy's flagship journals, the Journal of the Academy of Marketing Science (JAMS) and AMS Review (AMSR). Volumes are edited by leading scholars and practitioners across a wide range of subject areas in marketing science.

This book comprehensively explores all of the underlying issues and elements which, together, constitute one of the most successful quality and management programmes upon which companies such as Motorola and GE base their success - Six Sigma. The author was directly involved in implementing Six Sigma quality principles and practices into a European division of GE Capital, deploying this initiative in an entirely service-oriented business for the first time. Drawing from and reflecting on his experience, Geoff Tennant develops a reasoned exploration of the benefits that Six Sigma offers to any organization and what can be expected from start to finish. He investigates the relationship between Six Sigma and quality, customer satisfaction, business processes and organizational structure, statistics and analysis and process improvement methodologies. Aimed at quality professionals, senior management and directors, as well as practitioners and students of Six Sigma, Six Sigma: SPC and TQM in Manufacturing and Services provides an in-depth but highly readable insight into the quality initiative that is certain to sweep European companies as it has large and global American corporations.

Currently, the prime focus for US business plans should not be on the manufacturing process design and delivery processes, but on greatly improving innovation leadership, design engineering capability, and sales and marketing innovation. These three areas have been sadly lacking significant performance improvement during the past 20 years. The magic word for US business is "simplification." Most of the books written to date focus on the solution development aspect of the Innovation System Cycle, which is less than 15% of the total innovative system. Focusing on solution development is only the start -- the rest of the innovation system cycle is what turns an idea into a profitable business. The techniques in this book are directed at key tasks across the innovative process, such as maximizing quality, productivity, maintainability, usability, and reliability, while focusing on reducing the product cycle time and costs within the innovative process. This book uses more than 50 different approaches/concepts, which leads the reader in a very simple method for understanding, establishing, and effectively using an innovative system to provide a significant marketing advantage. Previous books have focused on what to do; however, this book focuses on how to do it. It transforms a complicated complex system into easy-to-use and understand methodology.

"Covers global and domestic competition, marketing strategies, operating expenses, and environmental and safety regulations for chemical professionals at all levels. Contains up-to-date mergers and acquisitions of chemical companies."

From its invention as a cocaine-laced patent medicine in the Gilded Age to its globe-drenching ubiquity as the ultimate symbol of consumer capitalism in the twenty-first century, Coca-Cola's dramatic history unfolds as the ultimate business saga. In this fully revised and expanded edition of "For God, Country & Coca-Cola," Mark Pendergrast looks at America's cultural, social, and economic history through the bottom of a green glass Coke bottle and tells the captivating story of the world's most recognizable consumer product.

This text lists the necessary steps for meeting compliance requirements during the drug development process. It presents comprehensive approaches for validating analytical methods for pharmaceutical applications.

Over the past two decades, society has been witnessing how technological, political, and societal changes have been transforming individual and collective urban mobility. Driven both by newcomers and traditional players, by disruptive as well as incremental innovations, the main objective now is to enhance mobility and accessibility while, reducing vehicle ownership, congestion, road accidents, and pollution in cities. This transformation has been mainly enabled by the widespread adoption of internet-connected devices (e.g.: smartphones and tablets) and by the innovative business models, technologies, and use-cases that arose from this rapid digitalization, such as peer-to-peer, and two-sided markets providing several mobility schemes: car-sharing, car-pooling, bike sharing, free-floating (cars, bikes, electric scooter), ridesharing and ride hailing either for long distances as well as for urban and micro-mobility. The book presents - in a holistic perspective - how this revolution is happening and what are the major cornerstones for the implementation of robomobility. It aims at answering several substantial issues, such as: What is robomobility and what does it imply for the different stakeholders of the public transport ecosystem? How do policy makers integrate this innovation and how ready the regulations are? How do citizens take part in this transformation? What is the level of user acceptance for this new type of mobility? What are its environmental impacts? What is the economic impact of deploying these shuttles in a local ecosystem?

This is the inside story of the workings of the MG Design and Development Office in Abingdon, from 1956 until MG's closure in 1980, as told by Chief Design & Development Engineer, Don Hayter. This book explains how the various models were conceived, drawn, planned and developed by a small team of engineers. It also shows how the constant evolution of BMC, including the Triumph-Austin merger, frequently changed input to, and control of, the department. Safety legislation, mainly imposed by the United States, could have killed MG, but detailed here are the design changes that allowed the MGB, and other models, to survive. Trying to remain as individual as possible, MG developed record-breakers and a unique Competition Department during the period covered by this book. Special cars were built and tested, and prototypes for the MGB replacement, using engines from any part of the group, were drawn up. The continuing support of the American market was essential and much valued, but holding company, British Leyland, prioritised the TR7 - a decision that, ultimately, led to the closure of a successful, happy MG company.

This comprehensive handbook represents a definitive state of the current art and science of food waste from multiple perspectives. The issue of food waste has emerged in recent years as a major global problem. Recent research has enabled greater understanding and measurement of loss and waste throughout food supply chains, shedding light on contributing factors and practical solutions. This book includes perspectives and disciplines ranging from agriculture, food science, industrial ecology, history, economics, consumer behaviour, geography, theology, planning, sociology, and environmental policy among others. The Routledge Handbook of Food Waste addresses new and ongoing debates around systemic causes and solutions, including behaviour change, social innovation, new technologies, spirituality, redistribution, animal feed, and activism. The chapters describe and evaluate country case studies, waste management, treatment, prevention, and reduction approaches, and compares research methodologies for better understanding food wastage. This book is essential reading for the growing number of food waste scholars, practitioners, and policy makers interested in researching, theorising, debating, and solving the multifaceted phenomenon of food waste.