Blockbuster drugs-each of which generates more than a billion dollars a year in revenue-have revolutionized the industry since the early 1980s, when sales of Tagamet alone transformed a minor Philadelphia-based firm into the world's ninth-largest pharmaceutical company. In Blockbuster Drugs, Jie Jack Li tells the fascinating stories behind the discovery and development of these highly lucrative medicines, while also exploring the tumult the industry now faces as the "patent cliff" nears. Having spent most of his career in drug research and development, Li brings an insider's eye to the narrative as he recounts the tales of discovery behind such drugs as Tagamet, Zantac, Claritin, Prilosec, Nexium, Serouquel, Plavix, and Ambien. As he discusses each breakthrough, Li also shows that scientific research is filled with human drama-serendipitous discoveries, sudden insights, tense confrontations. For instance, the author tells of James Black, who persisted in the research that led to Tagamet-and that would ultimately win him a Nobel Prize-despite pressure from top executives to pursue "more profitable" work. The book shows how research behind Prilosec combined creativity, international cooperation, and luck-the turning point being a chance encounter of American and Swedish scientists at a conference in Uppsala. There are also tales of fabulous rewards-George Rieveschl, the chemist who invented Benadryl, made a fortune on royalties-and of unjust desserts. Finally, Li shows that for the world's largest prescription drug manufacturers, recent years have been harrowing, as many popular drugs have come off patent in the U.S. market, meaning hundreds of billions of dollars in lost revenue. Anyone who enjoys tales of scientific discovery, or is curious about the history behind the prescriptions they take, or wants a revealing inside look at the pharmaceutical industry will find this book well worth reading.

Food is a source of nourishment, a cause for celebration, an inducement to temptation, a means of influence, and signifies good health and well-being. Together with other life enhancing goods such as clean water, unpolluted air, adequate shelter and suitable clothing, food is a basic good which is necessary for human flourishing. In recent times, however, various environmental and social challenges have emerged, which are having a profound effect on both the natural world and built environment - such as climate change, feeding a growing world population, nutritional poverty and obesity. Consequently, whilst the relationships between producers, supermarkets, regulators and the individual have never been more important, they are becoming increasingly complicated. In the context of a variety of hard and soft law solutions, with a particular focus on corporate social responsibility (CSR), the authors explore the current relationship between all actors in the global food supply chain. Corporate Social Responsibility, Social Justice and the Global Food Supply Chain also provides a comprehensive and interdisciplinary response to current calls for reform in relation to social and environmental justice, and proposes an alternative approach to current CSR initiatives. This comprises an innovative multi-agency proposal, with the aim of achieving a truly responsible and sustainable food retail system. Because only by engaging in the widest possible participatory exercise and reflecting on the urban locale in novel, material and cultural ways, is it possible to uncover new directions in understanding, framing and tackling the modern phenomena of, for instance, food deserts, obesity, nutritional poverty and social injustice. Corporate Social Responsibility, Social Justice and the Global Food Supply Chain engages with a variety of disciplines, including, law, economics, management, marketing, retailing, politics, sociology, psychology, diet and nutrition, consumer behaviour, environmental studies and geography. It will be of interest to both practitioners and academics, including postgraduate students, social scientists and policy-makers.

Strategic success of industry depends upon manufacturing competencies (i.e., the competitive advantage to ensure better quality and reliability), which will increase sales and create a sound customer base. Competitive priorities are the operating advantages that are assessed, evaluated, and measured within the parameters of cost, quality, time, design, and flexibility. The book explains the manufacturing competencies upon which the strategic success of the automobile industry depends. The impact of manufacturing competency on strategic success is analyzed and modelled using suitable qualitative and quantitative techniques. Key Features Outlines manufacturing competencies in correlation with successful strategic planning for current manufacturing environment Provides methodology or guidelines for linking defined strategic plans with manufacturing competencies Defines strategic success in the context of the automobile industry Analyses and models manufacturing competency impacts using qualitative and quantitative techniques Develops qualitative models with real-time case studies

Ontario boasts a potent mix of brewing traditions. Wherever Europeans explored, battled, and settled, beer was not far behind, which brought the simple magic of brewing to Ontario in the 1670s. Early Hudson's Bay Company traders brewed in Canada's Arctic, and Loyalist refugees brought the craft north in the 1780s. Early 1900s temperance activists drove the industry largely underground but couldn't dry up the quest to quench Ontarians' thirst. The heavy regulation that replaced prohibition centralized surviving breweries. Today, independent breweries are booming and writing their own chapters in the Ontario beer story.

Animal products are good source of disposable income for many small farmers in developing countries. In fact, livestock are often the most important cash crop in many small holder mixed farming systems. Livestock ownership currently supports and sustains the livelihoods of rural poor, who depend partially or fully on livestock for their income and/or subsistence. Human population growth, increasing urbanization and rising incomes are predicted to double the demand for, and production of, livestock products in the developing countries over the next twenty years. The future holds great opportunities for animal production in developing countries. Animal Sourced Foods for Developing Economies addresses five major issues: 1) Food safety and nutritional status in developing world; 2) the contribution of animal origin foods in human health; 3) Production processes of animal foods along with their preservation strategies; 4) functional outcomes of animal derived foods; and finally, 5) strategies, issues and polices to promote animal origin food consumption. Animal sourced food contain high biological value protein and important micronutrients required for optimal body functioning but are regarded as sources of fat that contribute to the intake of total and saturated fatty acids in diet. The quality of protein source has a direct influence on protein digestibility, as a greater proportion of higher quality proteins is absorbed and becomes available for bodily functions. Animal foods has high quantity and quality of protein that includes a full complement of the essential amino acids in the right proportion. Land availability limits the expansion of livestock numbers in extensive production systems in most regions, and the bulk of the increase in livestock production will come from increased productivity through intensification and a wider adoption of existing and new production and marketing technologies. The significant changes in the global consumption and demand for animal source foods, along with increasing pressures on resources, are having some important implications for the principal production systems. In this book, contributors critically analyze and describe different aspects of animal's origin foods. Each chapter is dedicated to a specific type of food from animal source, its nutritional significance, preservation techniques, processed products, safety and quality aspects on conceptual framework. Special attention is given to explain current food safety scenario in developing countries and contribution of animal derived food in their dietary intake. Existing challenges regarding production, processing and promotion of animal's origin foods are also addressed with possible solutions and strengthening approaches.

Originally published in 1980 but re-issued now with a new preface, this book looks at the German manager from a sociological viewpoint and explains why German management has been so successful and highlights the key factors in the training of the German manager and the attitudes and skills he develops in his work. The views and aspirations of German managers themselves are discussed in the light of the author's first-hand acquaintance with German industry. Throughout there is comparison with the UK, USA and other European countries. The manufacturing function is the subject of a special examination. It is argued that although German management has adopted some American practices the ethic is strictly German and an essential part of the German character.

Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

From a managerial perspective, the biopharmaceutical industry represents a competitive, fast-changing, intellectually-powered, innovation-driven sector. Many management scholars have studied this discontinuous era to make sense of strategic behavior and the cognition of firms and top managers. A past look at the biopharmaceutical industry provides answers to questions that most managers have. For example, what options do you have and what actions do you take when new firms enter your industry? In the 1970s, new biotechnology firms, funded by venture capitalists, appeared in the pharmaceutical industry with new knowledge. Successful pharmaceutical firms decided to collaborate with the new entrants and forge relationships to develop and create new, biotechnology engineered drugs. Thus, the addition of new biotechnology firms ushered in a new business model based on strategic alliances. Strategic alliances have now become an industrial norm called open innovation. The author looks at the historical path of the biopharmaceutical industry, particularly in the United States. While the pharmaceutical industry's main contributions to society are substantial, there are pressing challenges the industry must face, such as an increase in infectious disease outbreaks or the global aging population, which require new types of care, additionally, mental health care and prescription painkiller addiction are persistent issues with economic repercussions to both federal and local governments. This book presents a holistic view of the biopharmaceutical industry, putting it in a historical context. It will best serve those who are eager to learn about this dynamic, fast-evolving industry and who would like to tackle current biopharmaceutical industry issues in the United States and be prepared for future industry challenges.

Export marketing holds the promise of vastly increased sales and market share for companies of all sizes. This book gives you the tools you need to go from ground zero -- virtually no experience in international marketing -- to the point where you can confidently pull together an effective plan for marketing your products overseas.

In the twentieth century, dyes, pharmaceuticals, photographic products, explosives, insecticides, fertilizers, synthetic rubber, fuels, and fibers, plastics, and other products have flowed out of the chemical industry and into the consumer economies, war machines, farms, and medical practices of industrial societies. The German chemical industry has been a major site for the development and application of the science-based technologies that gave rise to these products, and has had an important role as exemplar, stimulus, and competitor in the international chemical industry. This volume explores the German chemical industry's scientific and technological dimension, its international connections, and its development after 1945. The authors relate scientific and technological change in the industry to evolving German political and economic circumstances, including two world wars, the rise and fall of National Socialism, the post-war division of Germany, and the emergence of a global economy. This book will be of interest to historians of modern Germany, to historians of science and technology, and to business and economic historians.

How often do we stop to recognize what pharmaceutical advertisements are telling us? Broadcast Pharmaceutical Advertising in the United States: Prime Time Pill Pushers engages with this question to include how pharmaceutical companies are shaping the meaning of drug interventions for individuals and the ways in which pharmaceutical advertisements frame issues of identity and representation for patients and health care. Such issues highlight how patients are being framed as consumers in these advertisements, which then permits the commodification of health care to be celebrated. Such a celebration has strong ideological implications, including definitions of "the good life," patient agency, and the role of DTCAs in such depictions. By defining and discussing medicalization, pharmaceuticalization, and commodity fetishism, this book introduces how the term "pharmaceutical fetishism" can act as a means for describing the commodification of brand-name pharmaceutical drugs, which, via advertising and promotional culture, ignores large-scale production and for-profit motives of "big pharma."

This text identifies and discusses different technology innovation initiatives (TIIs) such as entrepreneurial capability, technology infrastructure capability, organizational culture and climate, and government initiatives. It further evaluates the relationship between various technology innovation initiatives and manufacturing performances using multi-criteria decision-making techniques such as fuzzy set theory (FST), structural equation modeling (SEM), and analytic hierarchy process (AHP). It will serve as an ideal reference text for graduate students and academic researchers in the field of industrial engineering, manufacturing engineering, mechanical engineering, automotive engineering. This book: * Discusses technology innovation initiatives such as entrepreneurial capability, technology infrastructure capability, and organizational culture. * Highlights technology innovation-strategy model in assisting manufacturing industries for enhancing their performance in today's competitive environment. * Examines the effect of technology innovation initiatives on the performance of manufacturing industries. * Covers multi-criteria decision-making techniques such as fuzzy set theory, structural equation modeling, and analytic hierarchy process. * Explores the validation of fuzzy-based technology innovation model through structural equation modeling.

First published in 1988. This collection of essays examines aspects of labour and industrial relations history in the textiles sector of Northern England during the mature phase of industrialisation before World War One and the period of retrenchment during the interwar economic recession. There are chapters on wool, worsted, silk, cotton spinning and weaving, and cotton finishing. The volume includes contributions by historians interested in employers' organisations and management strategies, labour, trade union and women's history. As such it provides a broader framework in which relationships between capital and labour are analysed. The book also incorporates some of the recent research on particularly neglected areas of social history, most notably on women workers and on the industrial relations policies of employers in textiles.

First published in 1990. Patterns of Labour explores the interaction between home, paid work, and the individual. It looks at how the social relations of work both shape and are shaped by the context in which they occur. In a detailed examination of the pottery industries of Britain and America over two centuries, Richard Whipp looks at the far-reaching effects of key issues, such as industrialisation and economic transformation. However, he also examines changing notions of gender, the family, community and unionisation. The book centres on the difficulties of organising, controlling and describing work - not least because of the human act of its making.

The 1898 suppression of white phosphorous in the French match industry was a victory of organized labour. At a time when most French workers did not have the power to effect changes in the health and safety conditions of their work, the match workers succeeded. At a time when most French women were not unionised and did not pursue effective action on occupational health problems, French women in the match industry succeeded. This book, first published in 1989, examines their actions and provides the definitive account of their success.

Emphasises an introduction and explanation of the practical methods used in reliability, and risk studies with a discussion of their uses and limitations Offers basic and advanced methods in reliability analysis that are commonly used in daily practice Provides methods that address unique topics such as dependent failure analysis, importance analysis, and analysis of repairable systems Presents a comprehensive overview of modern probabilistic life assessment methods such as Bayesian estimation, system reliability analysis, and human reliability Includes many ends of chapter problems, a tools website with computational codes, along with a solutions manual to support course adoptions

German industry in particular is a central focus for studying technical and organizational changes in industry due to its pivotal position in international markets, its technological sophistication and its well-established training systems. Originally published in 1992, this study brings together contributions which contain both theoretical approaches and extensive empirical studies, on the manufacturing industry in Germany, including comparisons to other european countries. It looks at the developments of new technology, identifying trends in rationalization and the influences they have on organizational behaviour. As it discusses the relationships between technology and the work-force it includes discussion on flexible specialization, labour processes, union relations, small and large firms and training processes.

Europe is the cradle of the modem international chemical industry. From the middle of the nineteenth century until the outbreak of World War I, the European chemical industry influenced not only the production and control of science and technology, but also made significant contributions towards economic development, as well as bringing about profound changes in working and living enviromnents. It is a highly complex heritage, both rich and threatening, that calls for close scrutinity. Fortunately, a unique opportunity to explore the historical development of the European chemical industry from a variety of novel standpoints, was made possible during 1993 as part of the European Science Foundation (ESF) programme called 'The Evolution of Chemistry in Europe, 1789-1939.' This process of exploration has taken place through three workshops, each dealing with different time periods. The workshop concerned with the period 1850-1914, which corresponds roughly to the so-called Second Industrial Revolution, was held in Maastricht, The Netherlands, on 23-25 March 1995. This volume is the outcome of that workshop. The other workshops dealing with European chemical industry were held in Liege in 1994, covering the First Industrial Revolution period, 1789-1850, and Strasbourg in 1996, covering the period between the two World Wars.

Around the world, food has probably never been as safe as it is today. However, periodic crises have aroused consumer anxiety and contributed to a general lack of confidence in the agro-industrial system. The diverse nature of these crises increases governments' and industry difficulties in predicting and tackling them. This book addresses the relations between risk and food theoretically and empirically through case studies from Japan and China. Part I of the book examines the interaction between theoretical aspects and decision-making. The book theorizes the links between food and risk and analyses the decision-making process in light of risks and governance. The relationship between food risks, governance systems and economic decisions is assessed to explore ideas such as the "pact of nutrition" and the theory of weak signals. Part II examines case studies from China and Japan in the aftermaths of recent crises such as the milk powder scandal in China and food safety following the Fukushima nuclear accident and tsunami in Japan. This book will be an important resource for scholars, academics and policy-makers in the fields of sociology, economics, food studies, Chinese studies and Japanese studies and theories of risks and safety.

This book highlights the concepts of lean manufacturing that help to achieve the objectives of sustainability in a global competitive atmosphere. Lean can help to lower the manufacturing cost in the rising labour and material cost market. Lean is based on various fundamental concepts such as Kaizen, Kanban, Zidoka, 5S and Six Sigma, which aim at reducing process waste for efficiency and productivity that are discussed in this book. In addition, the technological changes such as introduction of Internet technologies and Industry 4.0 are taken care by the lean concepts, which are also addressed in this book.

Did Patrizia Reggiani murder her ex-husband, Maurizio Gucci, in 1995 because his spending was wildly out of control? Did she do it because her glamorous ex was preparing to marry his mistress, Paola Franchi? Or is there a possibility she didn't do it at all?

In this gripping account of the ascent, eventual collapse, and resurrection of the Gucci dynasty, Sara Gay Forden takes us behind the scenes of the trial and exposes the passions, the power, and the vulnerabilities of the greatest fashion family of our times.

The process of development in recent times has been characteristically marked by the expanding reach of multinational enterprises, flows of foreign direct investment, unprecedented growth of information and communication technologies (ICT) and knowledge-based industries, and infusion of ICT across the entire spectrum of industries and activities. High-tech knowledge-based industries like information technology, biotechnology, pharmaceuticals and so on have played an important role in the transition of Chinese and Indian economies-the two largest and fastest growing economies. This inter-disciplinary book offers an in-depth understanding of the behaviour of firms in these industries, analysing the strategies they adopt in a globally competitive environment, the role they have played in ushering in the growth revolution in China and India, and the contribution they have made to the nature and growth of employment. This study also dwells upon the emerging nature of scientific and technological developments like nanotechnology, novel materials, spintronics and quantum computers, with the conclusion that in the future, knowledge and technology are going to be the real sources of wealth for nations.

Exploring the issue of foreign ownership of corporate America, a leading economist and the president of the steel producer, Esmark, revisit the sale of that company to a Russian firm. Is it a good idea to allow foreigners to purchase critical and strategic American assets? No, say authors James Koch and Craig Bouchard. In America for Sale: How the Foreign Pack Circled and Devoured Esmark, Koch and Bouchard use the sale of Esmark-a transaction that put over 50 percent of American steel production into foreign hands-to make the case that this trend presents a clear and present danger to the economic future of United States of America. America for Sale recaps the amazing, sometimes incredible events leading up to the sale of Esmark, including intense pressure from the United Steelworkers and the company's major public shareholder to make a decision not in the best interest of all shareholders. It also analyzes the efforts by the Esmark board of directors to observe its fiduciary duty, details the company's "poison pill" effort to raise its sales price, and describes the actions of Leo Gerard and Ron Bloom of the United Steelworkers Union-which led to some surprising alliances. The authors-one Esmark's president and vice chairman of the board, the other an Esmark director, preeminent American economist, and former university president-then provide their own assessment of the Esmark story. They offer legislative and policy prescriptions aimed at making sure U.S. business doesn't devolve into one big garage sale to foreigners seeking to take advantage of the coming decline of the U.S. dollar. Previously unseen documents relating to the hostile reverse tender merger of Esmark, a historic first in unseating the board of directors of a publicly traded company in the United States A chronology of the "America for Sale" phenomenon and of key events in the American steel industry, from the 1970s to 2009 Approximately 25 tables and one dozen graphs that make it easy for readers to interpret data related to the Esmark sale and the overall foreign stake in American companies Text boxes that focus on human interest stories and the amazing quirks attached to the sale of Esmark-for example, one of the Russian bidders also was interested in acquiring the Pittsburgh Penguins hockey team and preventing its star Russian hockey player from leaping from a team in the remote Ural mountains to the NHL; that star subsequently led the NHL in scoring in the 2009 NHL season

This study of Ferranti in its last six years of a long history provides a detailed exposition of the British and American businessmen who combined to terminate one of the UK's leading defence electronics firms. Involving action in the Middle East, South Africa and Pakistan, as well as the UK and USA, this highlights the precarious nature of international arms trading.

Bang & Olufsen, the famous Danish producer of high-end home electronics, is well known as an early exponent of value-based management: the idea that there should be consistency in what the organisation does, a certain continuity between what the company develops and sells, and the beliefs and practices of the employees. This study investigates how company values are communicated and the collective identity is articulated through the use of such concepts as 'culture', 'fundamental values', and 'corporate religion', as well as how employees negotiate these ideas in their daily working lives. As this book reveals, the identification of values, meant to create cohesion and solidarity among employees, came to symbolise and engender a split between the staff and the other parts of the company. By examining the rise and fall of the value-based management approach, this volume offers the indispensible insight of anthropological enquiry to expose how social realities challenge conventional management strategies and therefore must be considered in the development of new management techniques.