Considering the Patient in Pediatric Drug Development: How Good Intentions Turned into Harm addresses a fundamental challenge in drug development and healthcare for young patients. In clinical trials and clinical practice, the term "children" is used ambiguously to confer physiological characteristics to a chronological age limit, which in reality does not exist. This book outlines why the United States (US) and European Union's (EU) regulatory authorities, pediatric academia, and the pharmaceutical industry demand, support and perform pediatric drug studies, along with the key flaws of this demand that blurs the different administrative and physiological meanings of the term "child." In addition, the book covers why most pediatric regulatory studies lack medical sense and many even harm young patients and the conflicts of interest behind pediatric drug studies. It includes relevant information about the maturation of the human body regarding absorption, distribution, metabolism and excretion of food and drugs as well as key differences between newborns, infants, older children and adolescents.

Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the therapeutic use of drug delivery devices, including design, applications, and a description of the design of each device. While other books focus on the therapy, the primary emphasis in this book is on current technologies for DDS applications, including microfluidics, nanotechnology, biodegradable hydrogel and microneedles, with a special emphasis on wearable DDS. As part of the Developments in Biomedical Engineering and Bioelectronics series, this book is written by experts in the field and informed with information directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference.

This book explores sustainability within manufacturing enterprises and examines the concepts and principles of this field. It also reviews the quantitative and qualitative tools available for analytic assessment. It presents a new framework for sustainable manufacturing requirements and discusses the implementation of sustainable manufacturing in terms of practices, indicators, and sustainability level assessments. The book also details the important conditions necessary for the conversion of existing traditional plants to ones with more sustainable processes. Chapters explore topics including the assessment of economic sustainability, social sustainability, environmental sustainability, sustainable manufacturing practices, and sustainability optimization. Serving as a reference for engineers, managers, and practitioners involved in manufacturing, this book will also be a valuable resource to students and researchers of industrial engineering, manufacturing engineering, systems engineering, and operations management.

The fourth edition of Gambero Rosso's Top Italian Food & Beverage Experience features a selection of the best Italian food and beverage producers. This is the only guide in the sector classified according to product category to bring together over 1200 exceptional entities ready and willing to export a range of quality items. The guide includes a section on the best fresh fruit and vegetables, indicating the relative producer consortia and associations, making it an indispensable tool for foodies, but especially for industry players wanting to promote the best of 'Made in Italy', and for the 50,000 buyers who participate annually in Gambero Rosso's international events.

Exclusive title focussing on various elements of combing in spinning. Includes detailed functioning of conventional and modern combers. Explains various motions in combing pertaining to diferent timings. Discusses role of modern electronics in controlling the mechanisms and offering on-line controls. Features solved examples at the end to tackle problems at shop-floor level.

How food marketers make use of key variables--such as innovation; target market; market segmentation; image; and physical, environmental, and human resources--determines how successfully they sell their products. Michman and Mazze concentrate on the food industry as they examine what contributes to a successful marketing campaign. The authors discover that not all variables have to be used concurrently; some may be more important than others depending on environmental conditions, and the effective use of one variable may cancel the ineffectiveness of another. By focusing on the key variables to use in a volatile economic environment, by emphasizing lessons learned from both marketing successes and failures, and by demonstrating how to adapt key variables to changing conditions, Michman and Mazze help executives ensure the success of their marketing efforts.

Mazze and Michman examine 10 institutional formats in the American food marketing and distribution structure--supermarkets, fast-food, ice cream, soup, breakfast cereal, baby food, ethnic food, snack food, candy and soft-drinks. The supermarket industry is analyzed first with an overview of food marketing and distribution. Specific industries are then analyzed using the five key variables (innovation, image, target market, physical environment, and human resources) with a historical framework to help managers learn from past marketing mistakes. The authors emphasize that avoidance of past mistakes is essential for sound marketing strategy, a fact illustrated by the examples of companies afflicted by injuries who have disregarded this advice.

`A splendid analysis of how an automotive industry based on mass production has become an alien in our time - where diversity and personalised products and services have become the norm. Peter Wells presents an intriguing analysis of how the automotive industry can find ways forward and re-invent itself. A must read for all interested in sustainable mobility, as well as strategists in the automotive industry.' - Arnold Tukker, TNO Built Environment and Geosciences, The Netherlands `The Automotive Industry in an Era of Eco-Austerity examines how we can achieve sustainable personal mobility, using a wide range of ideas and concepts. As the author stresses, this is not about the search for the best single technology for developing a sustainable car - it is much wider than that. Rather this book is about the fact that fundamental change is needed. Anyone interested in the auto industry should read it - much recommended.' - David Bailey, Coventry University, UK `What the global automotive industry needs right now is ideas and this book is packed with them. Dr Wells is a master of turning a topic on its head in order to approach it from an angle that is both unique and enlightening. This book should be required reading for decision makers within the automakers, suppliers and governments, whose job it will be to shape the auto industry of tomorrow.' - Gareth Owen Davies, AutomotiveWorld.com The Automotive Industry in an Era of Eco-Austerity analyses the future prospects of the largest manufacturing sector in the world, the automotive industry, at a time of unprecedented global financial crisis and unrelenting environmental pressure. This unique book seeks to combine economic analysis with the environmental research to arrive at a comprehensive understanding of the forces that shape change in the automotive industry. It eschews the usual focus on technologies, and gives more attention to the impact of change on the business models and strategies adopted by the vehicle manufacturers, the scope for new entrants, and the implications for policy-makers. This richly textured book concludes that the achievement of a sustainable automotive industry will not be possible with `one best way', but that myriad technologies and business concepts, grounded in the distinct needs of different places and consumers, will be the basis of the future of mobility. Drawing on a wealth of industry data by virtue of the authors' record of many years researching the industry, this book will be invaluable to both students and researchers working within transport, industrial ecology, automobility, industrial policy, economics, regional development, sustainability, technology, and business models.

The U.S. laser industry is a major player in the country's economy, with its products used in factories, laboratories, offices, homes and motor vehicles around the country. The issues addressed by the laser industry during the past several decades - patent litigation, worker education, export controls, international standardization, and others - are those that any emerging high-tech industry will have to face. Offering a roadmap for future technology development and commercialization, this book chronicles the laser and electro-optics industry and its issues for business executives, scientists and technicians, attorneys, journalists, historians, and others.

The absorbing and everlasting subject of watch repairing has been dealt with in books in many languages throughout the years. But when de Carle first set out to write "Practical Watch Repairing" in 1946, it was with the intention of creating a textbook "that a watchmaker can understand, even if he can't read." With over 550 instructional black-and-white illustrations and an approach that assumes no prior watch-repairing experience, this book achieves and surpasses that lofty mission, and has been touted as "the best illustrated book on practical horology" ("Horological Journal") ever written. For the readers in his audience, de Carle has provided well-informed discourse on every topic a watchmaker, or aspiring watchmaker, needs to know. With "Practical Watch Repairing," even a layman can become a watch-repair specialist.

Covers advances in particulate drying and its importance in the process industry Highlights recent developments in conventional drying techniques and new drying technologies Helps readers gain insight into selecting the appropriate drying techniques for a particular product Summarizes various applications from a wide range of industries, including chemical, food, pharma, biotech, polymer, mineral, and agro-industries Envisages future research trends and demands in particulate drying

This book examines Foreign Direct Investment of major Korean automotive companies in Europe, with particular reference to how economic integration has affected the motivations and patterns of FDI and industrial location. The book is a valuable source of information on FDI, the automobile industry in Europe and South Korea and business decision-making process in general.

Leading international food retailers have in recent years expanded beyond national boundaries and started to operate on a global scale. This book describes the current state of play, looking in detail at the main competitors worldwide and analyzing the factors underlying their successes and failures. The authors are leading commentators on this industry and identify the essential characteristics of a global strategy in food retailing and include many compelling examples.

Research efforts in the past ten years have led to considerable advances in the concepts and methods of smart manufacturing. Smart Manufacturing: Concepts and Methods puts these advances in perspective, showing how process industries can benefit from these new techniques. The book consolidates results developed by leading academic and industrial groups in the area, providing a systematic, comprehensive coverage of conceptual and methodological advances made to date. Written by leaders in the field from around the world, Smart Manufacturing: Concepts and Methods is essential reading for graduate students, researchers, process engineers, and managers. It is complemented by a companion book titled Smart Manufacturing: Applications and Case Studies, which covers the applications of smart manufacturing concepts and methods in process industries and beyond.

Research efforts in the past decade have led to considerable advances in the concepts and methods of smart manufacturing. Smart Manufacturing: Applications and Case Studies includes information about the key applications of these new methods, as well as practitioners' accounts of real-life applications and case studies. Written by thought leaders in the field from around the world, Smart Manufacturing: Applications and Case Studies is essential reading for graduate students, researchers, process engineers and managers. It is complemented by a companion book titled Smart Manufacturing: Concepts and Methods, which describes smart manufacturing methods in detail.

An Introduction to Healthcare Informatics: Building Data-Driven Tools bridges the gap between the current healthcare IT landscape and cutting edge technologies in data science, cloud infrastructure, application development and even artificial intelligence. Information technology encompasses several rapidly evolving areas, however healthcare as a field suffers from a relatively archaic technology landscape and a lack of curriculum to effectively train its millions of practitioners in the skills they need to utilize data and related tools. The book discusses topics such as data access, data analysis, big data current landscape and application architecture. Additionally, it encompasses a discussion on the future developments in the field. This book provides physicians, nurses and health scientists with the concepts and skills necessary to work with analysts and IT professionals and even perform analysis and application architecture themselves.

Using site-specific optimization approaches in international manufacturing networks is increasingly proving insufficient. To solve this problem, several holistic and integrated alternatives have been developed to reflect a global perspective. This book presents advances in the St. Gallen Global Manufacturing Network Model and its application in numerous industry-, benchmarking- and research projects. The contents combine data-driven solutions with qualitative management frameworks for the strategic optimization of international manufacturing networks. In the first part, the book addresses the foundation of manufacturing network management and further describes the St. Gallen Operational Excellence approaches to manage plant performance. On this basis, the authors show how plant- and network-level performance can be enhanced via key improvement domains (e.g., strategy, configuration, coordination, performance management, digitalization). In turn, the second part demonstrates the application of the constructs in manufacturing companies from various industries. By combining research and practice, the book offers unique perspectives on the management of global production striving toward higher performance on manufacturing site and network level.

Winner of the Frederick Jackson Turner Award Winner of the Isaac and Tamara Deutscher Memorial Prize Winner of the C. L. R. James Award A New York Times Book Review Editors’ Choice A ProMarket Best Political Economy Book of the Year “The Next Shift is an original work of serious scholarship, but it’s also vivid and readable…Eye-opening.” —Jennifer Szalai, New York Times “A deeply upsetting book…Winant ably blends social and political history with conventional labor history to construct a remarkably comprehensive narrative with clear contemporary implications.” —Scott W. Stern, New Republic “Terrific…A useful guide to the sweeping social changes that have shaped a huge segment of the economy and created the dystopian world of contemporary service-sector work.” —Nelson Lichtenstein, The Nation Pittsburgh was once synonymous with steel, but today most of its mills are gone. Like so many places across the United States, a city that was a center of blue-collar manufacturing is now dominated by health care, which employs more Americans than any other industry. Gabriel Winant takes us inside the Rust Belt to show how America’s cities have weathered new economic realities. As steelworkers and their families grew older, they required more health care. Even as the industrial economy contracted sharply, the care economy thrived. But unlike their blue-collar predecessors, home health aides and hospital staff work unpredictable hours for low pay. Today health care workers—mostly women and people of color—are on the front lines of our most pressing crises, yet we have been slow to appreciate that they are the face of our twenty-first-century workforce. The Next Shift offers unique insights into how we got here and what could happen next.

This is an original and very well structured and informative book. Its particular interest stems from the multidimensional and detailed analysis of a set of core technologies and their uneven diffusion process in eight countries of quite different levels of development. It challenges received ideas about what really matters to democratize the access to new technologies and provides evidence-based suggestions for policy design. Scholars and students interested in the technological side of inequality will read this book with delight.' - Judith Sutz, Universidad de la Republica, UruguayInequality is one of the main features of globalization. Do emerging technologies, as they spread around the world, contribute to more inequality or less? This unique interdisciplinary text examines the relationships between emerging technologies and social, economic and other forms of inequality. Susan Cozzens, Dhanaraj Thakur, and the other co-authors ask how the benefits and costs of emerging technologies are distributed amongst different countries - some rich and some poor. Examining the case studies of five technologies across eight countries in Africa, Europe and the Americas, the book finds that the distributional dynamics around a given technology are influenced by the way entrepreneurs and others package the technology, how governments promote it and the existing local skills and capacity to use it. These factors create social and economic boundaries where the technology stops diffusing between and within countries. The book presents a series of recommendations for policy-makers and private sector actors to move emerging technologies beyond these boundaries and improve their distributional outcomes. Offering a broad range of mature and relatively new emerging technologies from a diverse set of countries, the study will strongly appeal to policy-makers in science, technology and innovation policy. It will also benefit students and academics interested in innovation, science, technology and innovation policy, the economics of innovation, as well as the history and sociology of technology. Contributors: B. Beckert, I. Bortagaray, L. Brito, R. Brouwer, S. Cozzens, M.P.Falcao, S.D. Gatchair, J.A. Holbrook, L.A. Pace, D. Thakur

The Story of Porsche is a compact and beautifully designed review of the iconic car manufacturer. From the alluring curves to the powerful engineering, Porsche has been synonymous with both luxury and race car manufacturing for more than 90 years. In The Story of Porsche, every component of the legendary brand's success is studied and celebrated, from turbulent beginnings to its ascent to the summit of car design and construction. Blending heritage with innovation and brand identity with creativity, Porsche has produced some of the most beloved models of sport and luxury car alike. From the timeless designs of the 911 and Carrera, to the dynamism of the 917, the fabled marque has instilled class and faultless engineering into each and every one of its creations. With 19 victories at Le Mans, Porsche has also proved itself to be as successful on the racetrack as it is on the streets; revered, respected and treasured in equal measure. These victories on both the podium and in the marketplace are rendered here in stunning detail through insightful text and exceptional photography. This is a story packed with blind corners and steep climbs, in a package that will sit perfectly on any Porsche fan's bookshelf.

The U.S. computer software industry dominates the globe. But why has this critical industry succeeded so dramatically in world competition when so many other strategic technologies have fallen to foreign suppliers? In a detailed and well-reasoned economic analysis, Siwek and Furchtgott-Roth present the first truly comprehensive examination of international trade in computer software.

The authors identify software as one of the fastest-growing industries in the United States as measured by value-added to gross domestic product, employment, and foreign sales. They document the historical importance of U.S.-produced software in both American and foreign markets and they present country-by-country assessments of software markets around the world. Siwek and Furchtgott-Roth identify the principal areas of advantage held by the U.S. software industry and they go on to assess the future prospects of U.S. software in world markets.

In the years since publication of the first edition of Food Wars much has happened in the world of food policy. This new edition brings these developments fully up to date within the original analytical framework of competing paradigms or worldviews shaping the direction and decision-making within food politics and policy. The key theme of the importance of integrating human and environmental health has become even more pressing. In the first edition the authors set out and brought together the different strands of emerging agendas and competing narratives. The second edition retains the same core structure and includes updated examples, case studies and the new issues which show how these conflicting tendencies have played out in practice over recent years and what this tells us about the way the global food system is heading. Examples of key issues given increased attention include: nutrition, including the global rise in obesity, as well as chronic conditions, hunger and under-nutrition the environment, particularly the challenges of climate change, biodiversity loss, water stress and food security food industry concentration and market power volatility and uncertainty over food prices and policy responses tensions over food, democracy and citizenship social and cultural aspects impacting food and nutrition policies.

This book analyzes the structural factors that underlie the persistent mass poverty and extreme inequality in South Asian countries. It highlights the fact that the supposed trade-off between output growth and job creation is a false dilemma. Growth can create jobs, and jobs can drive growth, mutually reinforcing one another. Increased employment and better jobs would mitigate the problems arising from a widening inequality gap. The book argues that policies focused on employment generation, mostly through industrialization, are the way forward in terms of providing livelihoods, sustaining growth and reducing inequality. The book is divided into two main parts. Part A explores cases in selected countries in South Asia in detail, primarily focusing on the opportunities and challenges of job creation in the manufacturing sector, as well as related issues, including constraints on manufacturing-sector growth in South Asia, exports and trade linkages, participation in value chains and the role of investment. In turn, Part B addresses a number of aspects that can promote a deeper understanding of strategies for industrialization and employment creation in the South Asian context, including regional cooperation, skill development, and industrial competitiveness. Gathering contributions from some of the region's top minds, this book is of interest to scholars, researchers, policymakers and industry analysts alike.

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications.

* provides an in-depth discussion of recent advances in sterilization * identifies obstacles that may be encountered at any stage of the validation program, and suggests the newest and most advanced solutions * explores distinctive and specific process steps, and identifies critical process control points to reach acceptable results * New chapters include disposable systems, combination products, nano-technology, rapid microbial methods, contamination control in non-sterile products, liquid chemical sterilization, and medical device manufacture.