A Mechanistic Approach to Medicines for Tuberculosis Nanotherapy examines drug carrier development for controlled, targeted, pH and stimuli responsive drug releases for tuberculosis. The book provides in-depth information about mycobacterium tuberculosis, tuberculosis formation, and synthetic procedures for carrier synthesis, characterizations and mechanistic approaches. Key topics include the properties and functions of nanomedicines and how they might be applied for clinical diagnosis and treatment. Emphasis is placed on the basic fundamentals, biomaterial formulations, design principles, fabrication techniques, and transitioning bench-to-bed clinical applications. This book is useful for new researchers who focus on nanomedicine, stem cell therapy and bone tissue engineering. In addition, it introduces experienced researchers and clinicians to key trends, thus increasing their knowledge in drug discovery for tuberculosis and nanomedicine.

Henry Bernard Loewendahl scrutinizes the relationship between multinational companies, regional development, and governments, using a framework of bargaining between government and multinationals. He critically analyzes the role of foreign investment in economic development, and examines how governments can link inward investment to regional economic development. Based on extensive use of data, interviews and case studies of Siemens and Nissan's UK investment, the book shows why MNCs have invested in the UK in the past, how they bargained with the government, and what the impact was on the national and regional economies. In particular, through linking the strategy of multinationals to the location advantages of the UK, it is argued that labor flexibility and incentives were crucial to investment decisions. Loewendahl recommends a framework to integrate endogenous and exogenous approaches to developments; and proposes a greater role for the region and the EU to control incentives and monitor multinationals.

This book explores sustainability within manufacturing enterprises and examines the concepts and principles of this field. It also reviews the quantitative and qualitative tools available for analytic assessment. It presents a new framework for sustainable manufacturing requirements and discusses the implementation of sustainable manufacturing in terms of practices, indicators, and sustainability level assessments. The book also details the important conditions necessary for the conversion of existing traditional plants to ones with more sustainable processes. Chapters explore topics including the assessment of economic sustainability, social sustainability, environmental sustainability, sustainable manufacturing practices, and sustainability optimization. Serving as a reference for engineers, managers, and practitioners involved in manufacturing, this book will also be a valuable resource to students and researchers of industrial engineering, manufacturing engineering, systems engineering, and operations management.

Exclusive title focussing on various elements of combing in spinning. Includes detailed functioning of conventional and modern combers. Explains various motions in combing pertaining to diferent timings. Discusses role of modern electronics in controlling the mechanisms and offering on-line controls. Features solved examples at the end to tackle problems at shop-floor level.

This book focuses on the implications of digitalisation in the mobility service industry. Based on an analysis of more than 450 survey responses, it explores and assesses mobility in the age of digitalisation. The content covers both changes in the relationship between the company and its customers and a potential paradigm shift among leading companies. The findings suggest that a shift from traditional mobility management to a more customer-centred management perspective is both widely accepted and increasingly necessary. Nevertheless, the inclusion of services that are not primarily concerned with overcoming spatial distances is considered to be less attractive. Given its scope, the book will be of interest to researchers and professionals who are involved in digitalisation in the mobility service industry.

Paper and the British Empire examines the evolution of the paper industry within British organisational frameworks and highlights the role of the Empire as a market and business-making area in a world of shrinking commerce and rising trade barriers. Drawing on a valuable range of primary sources, this book covers the period 1861-1960 and examines events from the establishment of free trade backed by the gold standard to Britain's membership of the European Free Trade Association. In the field of the paper industry, the speed and intensity of the industrialisation process around the globe have been shaped by a wide variety of variables, including the surrounding institutional framework; entrepreneurial and organisational strategies; the cost and accessibility of transport; and the availability of capital, knowledge, energy resources, and technology. The supply of papermaking raw materials has also been key and has historically been the most important determinant for geographical location and dominance. The research in this work focuses on the roles played by such variants, on the one hand, and demand characteristics on the other. In particular, it considers developments connected to a quest for Empire-grown raw materials in order to tackle the problem of the lack of indigenous raw materials and the resulting dependence on Scandinavian wood pulp imports. This text is of considerable interest to advanced students and researchers in economic history, business history, and the paper industry, and will also be useful to organisations working within the pulp and paper industries.

How food marketers make use of key variables--such as innovation; target market; market segmentation; image; and physical, environmental, and human resources--determines how successfully they sell their products. Michman and Mazze concentrate on the food industry as they examine what contributes to a successful marketing campaign. The authors discover that not all variables have to be used concurrently; some may be more important than others depending on environmental conditions, and the effective use of one variable may cancel the ineffectiveness of another. By focusing on the key variables to use in a volatile economic environment, by emphasizing lessons learned from both marketing successes and failures, and by demonstrating how to adapt key variables to changing conditions, Michman and Mazze help executives ensure the success of their marketing efforts.

Mazze and Michman examine 10 institutional formats in the American food marketing and distribution structure--supermarkets, fast-food, ice cream, soup, breakfast cereal, baby food, ethnic food, snack food, candy and soft-drinks. The supermarket industry is analyzed first with an overview of food marketing and distribution. Specific industries are then analyzed using the five key variables (innovation, image, target market, physical environment, and human resources) with a historical framework to help managers learn from past marketing mistakes. The authors emphasize that avoidance of past mistakes is essential for sound marketing strategy, a fact illustrated by the examples of companies afflicted by injuries who have disregarded this advice.

`A splendid analysis of how an automotive industry based on mass production has become an alien in our time - where diversity and personalised products and services have become the norm. Peter Wells presents an intriguing analysis of how the automotive industry can find ways forward and re-invent itself. A must read for all interested in sustainable mobility, as well as strategists in the automotive industry.' - Arnold Tukker, TNO Built Environment and Geosciences, The Netherlands `The Automotive Industry in an Era of Eco-Austerity examines how we can achieve sustainable personal mobility, using a wide range of ideas and concepts. As the author stresses, this is not about the search for the best single technology for developing a sustainable car - it is much wider than that. Rather this book is about the fact that fundamental change is needed. Anyone interested in the auto industry should read it - much recommended.' - David Bailey, Coventry University, UK `What the global automotive industry needs right now is ideas and this book is packed with them. Dr Wells is a master of turning a topic on its head in order to approach it from an angle that is both unique and enlightening. This book should be required reading for decision makers within the automakers, suppliers and governments, whose job it will be to shape the auto industry of tomorrow.' - Gareth Owen Davies, AutomotiveWorld.com The Automotive Industry in an Era of Eco-Austerity analyses the future prospects of the largest manufacturing sector in the world, the automotive industry, at a time of unprecedented global financial crisis and unrelenting environmental pressure. This unique book seeks to combine economic analysis with the environmental research to arrive at a comprehensive understanding of the forces that shape change in the automotive industry. It eschews the usual focus on technologies, and gives more attention to the impact of change on the business models and strategies adopted by the vehicle manufacturers, the scope for new entrants, and the implications for policy-makers. This richly textured book concludes that the achievement of a sustainable automotive industry will not be possible with `one best way', but that myriad technologies and business concepts, grounded in the distinct needs of different places and consumers, will be the basis of the future of mobility. Drawing on a wealth of industry data by virtue of the authors' record of many years researching the industry, this book will be invaluable to both students and researchers working within transport, industrial ecology, automobility, industrial policy, economics, regional development, sustainability, technology, and business models.

Non-linear phenomena pervade the pharmaceutical sciences. Understanding the interface between each of these phenomena and the way in which they contribute to overarching processes such as pharmaceutical product development may ultimately result in more efficient, less costly and rapid implementation. The benefit to Society is self-evident in that affordable treatments would be rapidly forthcoming. We have aggregated these phenomena into one topic "Pharmaco-complexity: Non-linear Phenomena and Drug Product Development".

This book highlights the Eco-design or Sustainable design in textiles and fashion, aimed at reducing their environmental impact throughout their life cycle. Sustainable design is one of the core elements practiced in various industrial sectors. The textiles and fashion sector, is also creating a huge environmental brunt in terms of various fibres, processes, consumption of various resources including dyes, chemicals and auxiliaries, etc,. Thus, sustainable design is the key to reduce the environmental impacts made out of textiles and fashion products. This book includes seven informative chapters to decipher the concept and applications of sustainable design in textiles and fashion.

Food Waste Recovery: Processing Technologies, Industrial Techniques, and Applications, Second Edition provides information on safe and economical strategies for the recapture of value compounds from food wastes while also exploring their re-utilization in fortifying foods and as ingredients in commercial products. Sections discuss the exploration of management options, different sources, the Universal Recovery Strategy, conventional and emerging technologies, and commercialization issues that target applications of recovered compounds in the food and cosmetics industries. This book is a valuable resource for food scientists, technologists, engineers, chemists, product developers, researchers, academics and professionals working in the food industry.

This book proposes that, within the automotive industry, revised marketing principles and innovative marketing strategies are needed to address more effectively the unprecedented challenges posed by the modern digital revolution. The starting point for these proposals is a thorough analysis of the evolution of marketing in the industry across three ages of technological innovations - the mechanical, the electronic, and the digital. The main objectives are first, to illustrate how study of the past can help carmakers as they move forward into the unknown, and second, to identify the main choices that they will face. The central premise is that unusual times call for unusual strategies. By mining the past in order to foresee likely future developments regarding competition and marketing strategies within the car industry, the book will appeal both to researchers and to present or future managers in the automotive and other innovation-driven sectors.

The influence of European Competition Law is global, and Competition Law and Regulation of Technology Markets takes a practical, integrated approach to competition law, which is becoming increasingly prominent in the technology sector in Europe - as demonstrated by a number of high profile cases such as Microsoft, Sony/BMG and Intel.
The book focuses on the information, communication and media markets that form the 'new economy'. It provides a coherent analysis of these various markets by considering the regulatory context, and by addressing the issues, and ensuing legal problems, that are common to them. These include; high fixed costs, the importance of intellectual property and standards, the impact of interoperability, and the prevalence of the network effect.
The book considers how EU competition rules interact with regulation, intellectual property law and data protection rules, and goes on to analyze the application of competition rules in four fields; communications networks, industrial intellectual property, creative intellectual property, and electronic commerce and services.. The book charts a clear path through this complex interaction of rules, and provides the competition law practitioner with the necessary tools to advise on legal problems in these sectors.

Considering the Patient in Pediatric Drug Development: How Good Intentions Turned into Harm addresses a fundamental challenge in drug development and healthcare for young patients. In clinical trials and clinical practice, the term "children" is used ambiguously to confer physiological characteristics to a chronological age limit, which in reality does not exist. This book outlines why the United States (US) and European Union's (EU) regulatory authorities, pediatric academia, and the pharmaceutical industry demand, support and perform pediatric drug studies, along with the key flaws of this demand that blurs the different administrative and physiological meanings of the term "child." In addition, the book covers why most pediatric regulatory studies lack medical sense and many even harm young patients and the conflicts of interest behind pediatric drug studies. It includes relevant information about the maturation of the human body regarding absorption, distribution, metabolism and excretion of food and drugs as well as key differences between newborns, infants, older children and adolescents.

The book provides a holistic and practical approach to lean management throughout the business value chain. The lean management framework and tools demonstrate the optimal design and use of methods, tools and principles for companies and organisations. The author describes comprehensively how lean management enables companies to concentrate on value-adding activities and processes to achieve a long-term, sustainable competitive advantage. A wealth of best practices, industry examples and case studies are used to reveal the diversity and opportunities of lean management methodologies, methods and principles. Moreover, the book shows how lean management principles are ultimately applied in industries like automotive, healthcare, education and services industries.

This book examines Foreign Direct Investment of major Korean automotive companies in Europe, with particular reference to how economic integration has affected the motivations and patterns of FDI and industrial location. The book is a valuable source of information on FDI, the automobile industry in Europe and South Korea and business decision-making process in general.

Leading international food retailers have in recent years expanded beyond national boundaries and started to operate on a global scale. This book describes the current state of play, looking in detail at the main competitors worldwide and analyzing the factors underlying their successes and failures. The authors are leading commentators on this industry and identify the essential characteristics of a global strategy in food retailing and include many compelling examples.

In the 1970s, as car enthusiasts in the U.S. grew bored with models manufactured under tightening pollution and safety regulations, some innovative dealers exploited a legal loophole-designed to allow U.S. soldiers and diplomats to return from abroad with their vehicles-to import exotic cars never intended for sale in America. During the 1980s, a rise in the value of the dollar made car shopping in Europe a bargain hunter's dream. A network of unauthorized "gray market" dealers emerged, bypassing factory channels. Middle-class Americans suddenly found they could afford a Mercedes or BMW. These cars had to pass through U.S. customs, equipped to handle only a few independent imports annually. As applications ballooned, the regulatory system collapsed. This is the story of a misunderstood but fascinating period in the automotive industry, when creative importers found ways to put American motorists in new Ferraris while the EPA and DOT were backed up with mounds of paperwork.

This is an original and very well structured and informative book. Its particular interest stems from the multidimensional and detailed analysis of a set of core technologies and their uneven diffusion process in eight countries of quite different levels of development. It challenges received ideas about what really matters to democratize the access to new technologies and provides evidence-based suggestions for policy design. Scholars and students interested in the technological side of inequality will read this book with delight.' - Judith Sutz, Universidad de la Republica, UruguayInequality is one of the main features of globalization. Do emerging technologies, as they spread around the world, contribute to more inequality or less? This unique interdisciplinary text examines the relationships between emerging technologies and social, economic and other forms of inequality. Susan Cozzens, Dhanaraj Thakur, and the other co-authors ask how the benefits and costs of emerging technologies are distributed amongst different countries - some rich and some poor. Examining the case studies of five technologies across eight countries in Africa, Europe and the Americas, the book finds that the distributional dynamics around a given technology are influenced by the way entrepreneurs and others package the technology, how governments promote it and the existing local skills and capacity to use it. These factors create social and economic boundaries where the technology stops diffusing between and within countries. The book presents a series of recommendations for policy-makers and private sector actors to move emerging technologies beyond these boundaries and improve their distributional outcomes. Offering a broad range of mature and relatively new emerging technologies from a diverse set of countries, the study will strongly appeal to policy-makers in science, technology and innovation policy. It will also benefit students and academics interested in innovation, science, technology and innovation policy, the economics of innovation, as well as the history and sociology of technology. Contributors: B. Beckert, I. Bortagaray, L. Brito, R. Brouwer, S. Cozzens, M.P.Falcao, S.D. Gatchair, J.A. Holbrook, L.A. Pace, D. Thakur

This book takes the reader through the expansion, restructuring and possible salvation of Malawi's main industry, tobacco. Malawi has been dependent on tobacco exports for a century, but now, with demand for Malawian tobacco declining fast, the country needs to diversify rapidly. The authors combine an innovative range of theory and methods to provide a comprehensive and incisive analysis of the dilemmas faced by countries which still rely on a limited number of agricultural commodities in the 21st century. This work will be ideal for scholars and researchers interested in political economy and African development.

Research efforts in the past ten years have led to considerable advances in the concepts and methods of smart manufacturing. Smart Manufacturing: Concepts and Methods puts these advances in perspective, showing how process industries can benefit from these new techniques. The book consolidates results developed by leading academic and industrial groups in the area, providing a systematic, comprehensive coverage of conceptual and methodological advances made to date. Written by leaders in the field from around the world, Smart Manufacturing: Concepts and Methods is essential reading for graduate students, researchers, process engineers, and managers. It is complemented by a companion book titled Smart Manufacturing: Applications and Case Studies, which covers the applications of smart manufacturing concepts and methods in process industries and beyond.

Research efforts in the past decade have led to considerable advances in the concepts and methods of smart manufacturing. Smart Manufacturing: Applications and Case Studies includes information about the key applications of these new methods, as well as practitioners' accounts of real-life applications and case studies. Written by thought leaders in the field from around the world, Smart Manufacturing: Applications and Case Studies is essential reading for graduate students, researchers, process engineers and managers. It is complemented by a companion book titled Smart Manufacturing: Concepts and Methods, which describes smart manufacturing methods in detail.

The fourth edition of Gambero Rosso's Top Italian Food & Beverage Experience features a selection of the best Italian food and beverage producers. This is the only guide in the sector classified according to product category to bring together over 1200 exceptional entities ready and willing to export a range of quality items. The guide includes a section on the best fresh fruit and vegetables, indicating the relative producer consortia and associations, making it an indispensable tool for foodies, but especially for industry players wanting to promote the best of 'Made in Italy', and for the 50,000 buyers who participate annually in Gambero Rosso's international events.