An exploration of the Totonac native community of Papantla, Veracruz, during the last half of the eighteenth century. Told through the lens of violent revolt, this is the first book-length study devoted to Papantla during the colonial era. The book tells the story of a native community confronting significant disruption of its agricultural tradition, and the violence that change provoked. Papantlas story is told in the form of an investigation into the political, social, and ethnic experience of an agrarian community. The Bourbon monopolisation of tobacco in 1764 disturbed a fragile balance, and pushed long-term native frustrations to the point of violence. Through the stories of four uprisings, Jake Frederick examines the Totonacs increasingly difficult economic environment, their view of justice, and their political tactics. Riot! argues that for the native community of Papantla, the nature of colonial rule was, even in the waning decades of the colonial era, a process of negotiation rather than subjugation. The second half of the eighteenth century saw an increase in collective violence across the Spanish American colonies as communities reacted to the strains imposed by the various Bourbon reforms. Riot! provides a much needed exploration of what the colony-wide policy reforms of Bourbon Spain meant on the ground in rural communities in New Spain. The narrative of each uprising draws the reader into the crisis as it unfolds, providing an entree into an analysis of the event. The focus on the community provides a new understanding of the demographics of this rural community, including an account of the as yet unexamined black population of Papantla.

The ultimate goal of drug product development is to design a system that maximizes the therapeutic potential of the drug substance and facilitates its access to patients. Pharmaceutical Dosage Forms: Tablets, Third Edition is a comprehensive resource of the design, formulation, manufacture, and evaluation of the tablet dosage form, and with over 700 illustrations it guides pharmaceutical scientists and engineers through difficult and technical procedures in a simple easy-to-follow format. New to the third edition:

Business Development in the Biotechnology and pharmaceutical industries accounts for over $5 billion in licensing deal value per year and much more than that in the value of mergers and acquisitions. Transactions range from licences to patented academic research, to product developments as licences, joint ventures and acquisition of intellectual property rights, and on to collaborations in development and marketing, locally or across the globe. Asset sales, mergers and corporate take-overs are also a part of the business development remit. The scope of the job can be immense, spanning the life-cycle of products from the earliest levels of research to the disposal of residual marketing rights, involving legal regulatory manufacturing, clinical development, sales and marketing and financial aspects.The knowledge and skills required of practitioners must be similarly broad, yet the availability of information for developing a career in business development is sparse. Martin Austin's highly practical guide spans the complete process and is based on his 30 years of experience in the industry and the well-established training programme that he has developed and delivers to pharmaceutical executives from across the world.

Coffee Culture: Local experiences, Global Connections explores coffee as (1) a major commodity that shapes the lives of millions of people; (2) a product with a dramatic history; (3) a beverage with multiple meanings and uses (energizer, comfort food, addiction, flavouring, and confection); (4) an inspiration for humor and cultural critique; (5) a crop that can help protect biodiversity yet also threaten the environment; (6) a health risk and a health food; and (7) a focus of alternative trade efforts. This book presents coffee as a commodity that ties the world together, from the coffee producers and pickers who tend the plantations in tropical nations, to the middlemen and processors, to the consumers who drink coffee without ever having to think about how the drink reached their hands.

KEEP CALM AND CONQUER YOUR WORLD Protect your ass-ets, from your brand, to your customers, to your cash flow. This book will walk you through the highs and lows of creating a business: how to rise up from the midst of discouragement, what it's like to hire and fire employees, collaborations with celebrities and philanthropic organizations, and the rollercoaster ride of making deals and partnerships. Stacy Igel, founder of global impact brand, BOY MEETS GIRL (R) shares the twenty-year journey of building her company, from the ground up while powering through life's challenges. Her book is a realistic, unvarnished look at what it means to be a businessperson, a woman, and a parent. Through Stacy's story and the stories of the kick-ass men and women who worked alongside her, you will learn how to: Be authentic and make your voice stand out in the marketplace. Build lasting success, and make a difference-at your own pace, on your own terms. Choose business partners and allies that align with your aspirations. Celebrate each milestone achieved and goal accomplished in your journey. Make a positive impact in your community and beyond. This book is a captivating, practical guide for new entrepreneurs, mompreneurs, and established entrepreneurs looking for insights and inspiration.

Cereal-Based Foodstuffs: The Backbone of the Mediterranean provides an overview of cereal-based products in the Mediterranean region, illustrating the spectrum of products from past to present and their various processing methods. The text explores new and understudied market trends in cereal-based products, such as cereal-pulse blends, pulse pastas, and flat breads. Chapters cover products originating in North Africa, such as bulgur and couscous, which are consumed worldwide but underrepresented in the scientific literature. Contributing authors also offer a legislative perspective on issues of food safety, the European Food Safety Association's definition of "novel foods," and the position of traditional foods in the Mediterranean food industry. This wide-ranging text thus serves members of both the scientific and industrial community seeking better coverage of global cereal product trends.

This work tells the full story of the weapons, including fighter-planes, tanks, ships, and guns, that America produced during the war to defeat the Axis powers, and how they were "sold" to those at home through the countless advertisements that appeared in popular magazines. Though well-known companies such as General Motors, Ford, Kelvinator, and B.F. Goodrich, and a whole host of others, could no longer sell their products to consumers, they instead turned their factories towards supplying the Arsenal of Democracy. In order to keep their names in the public spotlight, these companies advertised in great detail the weapons they were building; Cadillac touted its efforts in supplying components for Sherman tanks and P-38 Lightning fighters, Ford no longer built cars in Detroit, but B-24 Liberator bombers and Jeeps, while the home appliance company Kelvinator built aircraft components and flame-throwers. The story behind these advertisements, many of them stunning visuals which are here reproduced in color, is a unique aspect of World War II history that will both surprise and delight.

This unique textbook takes a holistic approach to food poisoning and food hygiene, explaining in clear and non-technical language the causes of food poisoning with practical examples from 'real-life' outbreaks. Now in its seventh edition, the book retains its longstanding clarity, while being completely revised and updated by a new team of editors and contributing authors. Hobb's Food Poisoning and Food Hygiene gives the reader a practical and general introduction to the relevant micro-organisms that affect food in relation to food safety and foodborne illness. Emphasis is given to the main aspects of hygiene necessary for the production, preparation, sale and service of safe food. Information about the behavior of microbiological agents in various foods, their ability to produce toxins and the means by which harmful organisms reach food is appliced to manufacture and retail procedures, and to equipment and kitchen design. For the first time the book includes coverage of waterborne infections and sewage and, through judiciuos selection of case examples, indicates the global nature of food and water hygiene today. The contribution of different professional groups to the control of food and waterborne organisms is also recognized. This book remains an essential course text for students and lectureres dealing with food science, public health, microbiology, environmental health and the food service industry. It also serves as an invaluable handbook for professionals within the food industry, investigators, researchers in higher education and those in the retail trade.

Large infrastructure projects generally involve multiple stakeholders such as government parties, local communities, and private organizations. New projects can create tensions between different stakeholder groups because different groups naturally have different interests and opinions. This book offers a view of how stakeholders are able to influence the project management's decision-making process as the project proceeds from the investment preparation phase, to the project execution phase, and on to the operations phase through various methods such as protests, legal battles, and even illegal activities. This book provides multiple case studies in aviation industry reflecting how large projects create dynamic contexts for stakeholder management and stakeholder behaviour as the project moves through different phases of its lifecycle.

This book focuses on the lives, struggles, and contrasting perspectives of the 60,000 workers, military administrators, and technical staff employed in the largest, most strategic industry of the Nationalist government, the armaments industry based in the wartime capital, Chongqing. The author argues that China's arsenal workers participated in three interlocked conflicts between 1937 and 1953: a war of national liberation, a civil war, and a class war. The work adds to the scholarship on the Chinese revolution, which has previously focused primarily on rural China, showing how workers' alienation from the military officers directing the arsenals eroded the legitimacy of the Nationalist regime and how the Communists mobilized working-class support in Chongqing. Moreover, in emphasizing the urban, working-class, and nationalist components of the 1949 revolution, the author demonstrates the multiple sources of workers' identities and thus challenges previous studies that have exclusively stressed workers' particularistic or regional identities.

During the last five years, clinical research and development costs have risen exponentially without a proportionate increase in the number of new medications. While patient recruitment for clinical studies is only one component in the development of a new medicine or treatment, it is one of the most significant bottlenecks in the overall drug development process. Now, it is imperative that industry leaders see beyond reactive measures and recognize that advancing their approach to patient recruitment is absolutely essential to advancing medicine and continuing the stability of their corporate brand across the globe. Reinventing Patient Recruitment: Revolutionary Ideas for Clinical Trial Success is a definitive guide to planning, implementing, and evaluating recruitment strategies and campaigns globally. The combined experience of the authors provides a depth of perspective and boldness of innovative leadership to set the standards for future patient recruitment programs and practices.This book is a must-have for pharmaceutical, biotechnology, and medical device industry professionals concerned with enrolling for domestic and multinational clinical studies and remaining on time and on budget.

This book reviews current health risk communication strategies, and examines and assesses the technical and psycho-sociological tools available to support risk communication plans. It brings together approaches to risk communication from a number of countries and describes the techniques, including drama, storytelling and scenarios that are used to identify and prioritise key communication issues, and to identify policy responses. The book also provides a review of the methods and tools available for risk assessment, risk communication and priority setting, which are relevant not only to practitioners but to health planning more generally, and to many other areas of public health and policy. The discussion of these techniques is supported by case studies, and is concluded by a chapter reflecting on the conceptual and research issues that still need to be addressed. It also proposes new directions for risk communication that key into the public imagination with the aim of gaining their trust and confidence in the risk messages. Communicating Health Risks to the Public: A Global Perspective brings together a wide variety of perspectives on risk communication, from the perspectives of health, anthropology, psychology, and media. It should be of interest not only to those involved in risk assessment or communication but to anyone interested in the role of science and the media in the political process.

Written by an experienced professional, the book introduces chemists to process development, using examples from the pharmaceutical, agrochemical and fragrance industries. The focus is on small molecules rather than biomolecules, and on relatively small-scale production rather than bulk petrochemicals. The coverage is broad, going from initial route development, through pilot plant operations, to full-scale production.

The challenges facing large pharmaceutical companies are stark: sales are slowing, and research and development costs are rising. There is an overwhelming need to reduce development costs by as much as 30-40%, while at the same time significantly shortening development cycle times. Pharmaceutical spend on outsourcing faces double-digit growth for the next three to five years and yet, if outsourcing is to meet these challenges, new models of collaborative and cooperative working are needed now. Outsourcing Clinical Development offers a guide to these new models and to future clinical outsourcing strategy. There is advice on the basis for an outsourcing strategy and guidance on how to work most productively with CROs (contract research organisations); geographical issues, including working in low-cost environments, are also covered. There is a detailed guide to selecting candidates, and managing the proposal, negotiation and contract process successfully; as well as reviewing outsourcing performance and developing fruitful long-term strategic relationships. The pharmaceutical outsourcing process is as complex and as influential as the clinical trials it supports. Outsourcing Clinical Development, with a powerful mix of perceptive insight from leading lights in the industry, advice on long-term strategic direction and tools for immediate help is a must-have read for pharmaceutical companies and their CRO partners.

'What gets measured gets fixed' and this is as true of the pharmaceutical industry as any other. The problem is that pharmaceutical businesses are complex. Drug research and development involves extended and expensive processes; defining appropriate metrics for these processes is not easy, yet ineffective or misguided metrics can be more damaging than none at all. David Zuckerman's Pharmaceutical Metrics is an extremely practical guide to selecting a system, selling it to top management, choosing and defining the right metrics for your system, communicating and displaying the results. And because metrics are about how to shape and develop your business, he explores how to deploy them organization-wide and make sure that they are driving business improvement. In order to reflect the needs of different types of pharmaceutical company the author uses four sample companies, throughout the book, to illustrate the principles for 'big pharma', 'micro pharma', a virtual development company and a CRO. This highly practical book provides a step-by-step guide to creating a state-of-the-art, strategy-driven metrics system for pharmaceutical R&D, supported by case studies of the techniques applied and tips for optimizing the system.

Volume two of the second edition of the comprehensive Handbook of Manufacturing Engineering illuminates the role of the manufacturing engineer as the key component of factory operation. The focus is on the planning and instruction duties that are critical to successful operations management, which fall upon the manufacturing engineer who may be unfamiliar with many of the planning and costing aspects. The book provides detailed descriptions of successful methods, including statistical methods for component reliability, practical cost estimating, and control of production and materials. The editors devote individual chapters to the very popular MOST Work Measurement Systems and the theory of constraints (TOC).

Although mercers have long been recognised as one of the most influential trades in medieval London, this is the first book to offer a comprehensive and detailed analysis of the trade from the twelfth to the sixteenth century. The variety of mercery goods (linen, silk, worsted and small manufactured items including what is now called haberdashery) gave the mercers of London an edge over all competitors. The sources and production of all these commodities is traced throughout the period covered. It was as the major importers and distributors of linen in England that London mercers were able to take control of the Merchant Adventurers and the export of English cloth to the Low Countries. The development of the Adventurers' Company and its domination by London mercers is described from its first privileges of 1296 to after the fall of Antwerp. This book investigates the earliest itinerant mercers and the artisans who made and sold mercery goods (such as the silkwomen of London, so often mercers' wives), and their origins in counties like Norfolk, the source of linen and worsted. These diverse traders were united by the neighbourhood of the London Mercery on Cheapside and by their need for the privileges of the freedom of London. Extensive use of Netherlandish and French sources puts the London Mercery into the context of European Trade, and literary texts add a more personal image of the merchant and his preoccupation with his social status which rose from that of the despised pedlar to the advisor of princes. After a slow start, the Mercers' Company came to include some of the wealthiest and most powerful men of London and administer a wide range of charitable estates such as that of Richard Whittington. The story of how they survived the vicissitudes inflicted by the wars and religious changes of the sixteenth century concludes this fascinating and wide-ranging study.

In this vivid ethnography, Paige West tracks coffee as it moves from producers in Papua New Guinea to consumers around the world. She illuminates the social lives of the people who produce coffee, and those who process, distribute, market, and consume it. The Gimi peoples, who grow coffee in Papua New Guinea's highlands, are eager to expand their business and social relationships with the buyers who come to their highland villages, as well as with the people working in Goroka, where much of Papua New Guinea's coffee is processed; at the port of Lae, where it is exported; and in Hamburg, Sydney, and London, where it is distributed and consumed. This rich social world is disrupted by neoliberal development strategies, which impose prescriptive regimes of governmentality that are often at odds with Melanesian ways of being in, and relating to, the world. The Gimi are misrepresented in the specialty coffee market, which relies on images of primitivity and poverty to sell coffee. By implying that the "backwardness" of Papua New Guineans impedes economic development, these images obscure the structural relations and global political economy that actually cause poverty in Papua New Guinea.

Financial Times Business Top Title March 2022 How could a large collection of small companies, most with fewer than 50 employees, rise to compete with Big Pharma, one of the world's most breathtakingly expensive and highly regulated industries? Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources. Biotech companies have met the challenge by creating nearly 40% more of the most important treatments for previously unmet medical needs. Moreover, they have done so with much lower overall costs. From Breakthrough to Blockbuster: The Business of Biotechnology focuses on both the companies themselves and the broader biotech ecosystem that supports them. It paints a portrait of the crucial roles played by academic research, venture capital, contract research organizations, the capital markets, and pharmaceutical companies, demonstrating how a supportive environment enabled the entrepreneurial biotech industry to create novel medicines with unprecedented efficiency. In doing so, it also offers insights for any industry seeking to innovate in uncertain and ambiguous conditions.

The principles of lean manufacturing increasing efficiency, reducing waste, lowering costs and improving control may be applied to any industry. However, the food industry is unique, and creates unique demands. The political, social and economic importance of food is unrivalled by any other form of produce, as is the scrutiny to which the manufacture of food is subjected. For the food industry, lean manufacturing is not simply a cost-saving strategy, but is directly linked to issues of sustainability, the environment, ethics and public accountability. Handbook of Lean Manufacturing in the Food Industry is a major new source of information and ideas for those working in food manufacturing. Offering a fresh and modern perspective on best practice, it points the way to fewer breakdowns, reduced quality faults, improved teamwork and increased profits. With a focus on operations management and new process development, the book is accessible and easy to read, and is complemented by a wealth of practical examples drawn from industry. The author s conversational style and questioning approach will be invaluable to food manufacturers who are seeking solutions to fundamental issues. The book is directed at those who are working in food manufacturing or the wider food industry, particularly factory operations managers and training teams who are looking for resources to help with lean manufacturing implementations. Others in the supply chain, from producers to retailers, will also find it invaluable. The book is a clear and timely introduction for students and lecturers in food science and technology who want to access the reality of lean manufacturing as well as the theory.

Written by John Lidstone and Janice MacLennan, the second edition of Marketing Planning for the Pharmaceutical Industry became accepted as the bible for the industry. In this new companion book Janice MacLennan picks up two of the themes touched on in Marketing Planning - market segmentation and branding, and the inter-relationship between these two - and with this book makes them key topics for discussion. Brand Planning for the Pharmaceutical Industry begins by exploring what branding is and why it is of importance, particularly to the pharmaceutical sector. The book then goes on to show how branding can be integrated into the early stages of the commercialization process for new products, both in theory and in the 'real' world. The book provides a step-by-step guide to brand planning, using market segmentation as the starting point. The book is split into two parts, the first dealing comprehensively with brand planning for products yet to get to the market, with the second part applying the same process to products that are already on the market. Both parts are extremely pragmatic, full of pertinent examples and insights from the pharmaceutical industry, and are directly applicable to your own brand planning. Brand Planning for the Pharmaceutical Industry concludes by confronting the problems that organizations are likely to have in actually making brand planning an integral part of their work and presents strategies for dealing with them.

In the last decade, there has been substantial research dedicated towards prospecting physiochemical, nutritional and health properties of novel protein sources. In addition to being driven by predictions of increased population and lack of a parallel increase in traditional protein sources, main drivers for the rise in novel proteins/ novel foods research activities is linked to significant changes in young consumers' attitudes toward red meat consumption and their interest in new alternative protein products. Alternative Proteins: Safety and Food Security Considerations presents up-to-date information on alternative proteins from non-meat sources and examines their nutritional and functional roles as food sources and ingredients. Emphasis is placed on the safety of these novel proteins and an evaluation of their potential contribution to food security. Motivations for novel proteins and restrictions for their use are also discussed. Key Features: Explains potential improvements to alternative proteins through the employment of novel processing techniques. Contains the first review on keratin as an alternative protein source. Explores first comprehensive evaluation of the religious aspects of novel proteins. Describes methods for the detection and evaluation of health hazards. Discusses guidelines, regulatory issues and recommendations for food safety Additionally, this book covers fundamental and recent developments in the production of alternative proteins, and examines safety and consumer acceptability wherever information is available. The sources and processing options for alternative proteins and their impact on final product characteristics are also covered. A collective contribution from international researchers who are active in their field of research and have made significant contributions to the the food sciences, this book is beneficial to any researcher interested in the the food science and safety of alternative proteins.

Tells the dual story of the growth in popularity in the United States from the 1860s onwards and the remarkable role it played in Central American history as a result of the chicle used in its production farmed on the Yucatan peninsula.

This fascinating, detailed book provides a sweeping survey of the hats produced by the company whose name is synonymous with cowboys and the Wild West. Surprisingly, though, the John B. Stetson Company was based in Philadelphia and produced all manner of headwear. Over 500 illustrations display never-before-worn Stetson hats (men's and women's alike), hat boxes, miniature boxes, and a surprisingly large number of collectible items associated with this most famous hat company. Original research charts the development of of the company, and individuals closely related with the firm provide their memories. Hat styles from the mid-nineteenth century to the late twentieth get a review, and for those lucky enough to own one of these valuable collectibles, there are tips on how to wear and care for vintage and modern Stetsons. Values for the hats illustrated, an extensive bibliography, and an index are included.