This textbook is designed for undergraduate students studying airspace engineering, as well as undergraduate and postgraduate students studying air transport management. It will also be very helpful for the training of air traffic control officers. The textbook does not require any prior (specialist) knowledge as it is an introduction to the Air Navigation Service Providers (ANSPs) business. There is very little literature available that gives a detailed appreciation of the complexities, potential risks and issues associated with the provision of air navigation services. The role of this textbook is to fill this significant gap with a comprehensive, in-depth study of the management principles related to Air Navigation Service Providers. This is particularly timely given recent ATC developments in Europe, USA, and New Zealand. Airlines and airports rely on the Air Navigation Service Providers (ANSPs) for the management of air traffic. Hence, Air Navigation Services (ANS) provision is considered as a core element for air transportation. This textbook addresses each of the Air Navigation Services' five broad categories of services provided to air traffic during all phases of operation: Air Traffic Management (ATM), Communication services, Navigation services and Surveillance services (CNS), Meteorological services for air navigation (MET), Aeronautical Information Services (AIS) and Search and Rescue (SAR). This textbook is designed for undergraduate students studying airspace engineering and undergraduate and postgraduate students studying air transport management. It will also be very helpful for the training of air traffic control officers. The textbook does not require any prior (specialist) knowledge as it is an introduction book to the Air Navigation Service Providers (ANSPs) business.

Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug delivery systems administered via various routes, such as oral, parenteral, transdermal and inhalational. Regulatory and product development topics are also explored. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of drug delivery systems within the pharmaceutical sciences industry and research, as well as in chemical engineering. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists. This book provides a comprehensive examination that is suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnologies, and related industries.

Formulation of Monoclonal Antibody Therapies: From Lab to Market covers a wide range of topics about therapeutic monoclonal antibodies (mAbs) with a focus on formulation aspects. Therapeutic monoclonal antibodies are used for treatment of chronic diseases. It brings together a comprehensive knowledge in one accessible volume. Starting with foundational information on monoclonal antibodies, the book then discusses the importance of biopharmaceutical products, monoclonal antibodies and biosimilars in treatment of chronic diseases, pharmaceutical aspects of mAbs, and how it can be administered. It also covers the industrial point of view and the clinical application of mAbs including in oncology, general medicine, rheumatology, hematology, dermatology, gastrointestinal tract, metabolic diseases, and dentistry. Formulation of Monoclonal Antibody Therapies: From Lab to Market is essential reading for researchers in biotechnology and biopharmaceutical fields, academics and pharmaceutical industrial scientists, and university students in pharmaceutical and biopharmaceutical sciences.

Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of 'Linker Chemistry' in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding. The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.

Using Scanner Data for Food Policy Research is a practitioners' guide to using and interpreting scanner data obtained from stores and households in policy research. It provides practical advice for using the data and interpreting their results. It helps the reader address key methodological issues such as aggregation, constructing price indices, and matching the data to nutrient values. It demonstrates some of the key econometric and statistical applications of the data, including estimating demand systems for policy simulation, analyzing effects of food access on food choices, and conducting cost-benefit analysis of food policies. This guide is intended for early-career researchers, particularly those working with scanner data in agricultural and food economics, nutrition, and public health contexts.

The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases. Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas. Key Features: Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and "WELLNESS" molecule Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals Presents flavonoid-based functional foods Discusses the flavonoid nutraceuticals market and future trends Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.

Emphasises an introduction and explanation of the practical methods used in reliability, and risk studies with a discussion of their uses and limitations Offers basic and advanced methods in reliability analysis that are commonly used in daily practice Provides methods that address unique topics such as dependent failure analysis, importance analysis, and analysis of repairable systems Presents a comprehensive overview of modern probabilistic life assessment methods such as Bayesian estimation, system reliability analysis, and human reliability Includes many ends of chapter problems, a tools website with computational codes, along with a solutions manual to support course adoptions

Offering a panoramic view of the history and culture of food and drink in America with fascinating entries on everything from the smell of asparagus to the history of White Castle, and the origin of Bloody Marys to jambalaya, the Oxford Companion to American Food and Drink provides a concise, authoritative, and exuberant look at this modern American obsession. Ideal for the food scholar and food enthusiast alike, it is equally appetizing for anyone fascinated by Americana, capturing our culture and history through what we love most-food! Building on the highly praised and deliciously browseable two-volume compendium the Oxford Encyclopedia of Food and Drink in America, this new work serves up everything you could ever want to know about American consumables and their impact on popular culture and the culinary world. Within its pages for example, we learn that Lifesavers candy owes its success to the canny marketing idea of placing the original flavor, mint, next to cash registers at bars. Patrons who bought them to mask the smell of alcohol on their breath before heading home soon found they were just as tasty sober and the company began producing other flavors. Edited by Andrew Smith, a writer and lecturer on culinary history, the Companion serves up more than just trivia however, including hundreds of entries on fast food, celebrity chefs, fish, sandwiches, regional and ethnic cuisine, food science, and historical food traditions. It also dispels a few commonly held myths. Veganism, isn't simply the practice of a few "hippies," but is in fact wide-spread among elite athletic circles. Many of the top competitors in the Ironman and Ultramarathon events go even further, avoiding all animal products by following a strictly vegan diet. Anyone hungering to know what our nation has been cooking an eating for the last three centuries should own the Oxford Companion to American Food and Drink. BL Nearly 1,000 articles on American food and drink, from the curious to the commonplace BL Beautifully illustrated with hundreds of historical photographs and color images BL Includes informative lists of food websites, museums, organizations, and festivals

The development of a robust drug product requires juggling many competing priorities such as overcoming scientific challenges, following regulatory requirements, and managing business-related concerns. Unfortunately, despite large resources spent on R&D, multifactor productivity of pharmaceuticals is on the decline for several years now. Because of this business reality, pharmaceutical companies have seen a notable change in the traditional operating model and footprint over the past couple of decades. Outsourcing, in particular, has emerged as a successful business model for many pharmaceutical companies looking for ways to strategically increase their R&D capabilities and to augment their in-house resources. How to Integrate Quality by Efficient Design (QbED) in Product Development bridges the gap between theory and practice when it comes to strategic decision-making in a pharmaceutical research scenario. This book will introduce the concept of QbED and focus on various aspects such as patient-centric product designs, platform-based manufacturing technologies, business acuity, and regulatory strategies to balance the challenges in outsourcing with the need for strategic and statistically sound experiments rooted in good science. Detailed discussions will cover pharmaceutical business models, regulatory approval process, quality by design (QbD), business analytics, and manufacturing excellence specifically for small molecules and solid oral dosage forms. With the addition of case studies, flowcharts, diagrams, and data visualizations, How to Integrate Quality by Efficient Design (QbED) in Product Development will be a practical reference to help professionals working in the area of pharmaceutical drug development, strategy, and outsourcing management.

The Spring Electric is a lower priced electrical vehicle from The Renault Group. It is the result of an impossible project that was a breakthrough in cultural innovation. The development of the Spring brought together a French company, a Japanese partner, an Indian project, and a Chinese developer to deliver a car for the European market. The Innovation Odyssey: Lessons from an Impossible Project examines four key issues central to this vehicle's development: The nature of the automotive industry itself and the actors involved in these "societal" innovations. The movement toward the electrification of vehicles is inseparable from public policies aimed at reducing carbon emissions. Without substantial subsidies or rigorous bans on internal combustion engine vehicles (ICEVs), the electric vehicle (EV) would not be developed. It is these public policies that create the conditions for an electrified vehicle market. Electrification is thus a three-way game, in which public actors play a central role alongside suppliers and customers. Therefore, an analysis of these policies is essential to understand manufacturers' strategies in this area. What are the differences between these policies? Do they introduce regional competitive advantages? How do firms in the globalized automotive sector adapt to or take advantage of these differences? How can they combine local adaptation. Product strategy. To what extent should this technological breakthrough at the heart of the car be associated with a more profound break in the definition of the automobile product? Is the answer an electrification of the dominant ICEV design (and if so, how?) or a complete redefinition of the vehicle? International cooperation. Automotive design is largely concentrated in the technical centers of the parent companies: Detroit, Guyancourt, Wolfsburg, Yokohama. How can the design processes and the European and Chinese skills and know-how be combined in a project designed far from the traditional European or Japanese bases and under time constraints? Can this original form of design inspire new forms of international cooperation, and under what conditions? Globalized innovation strategies. For multinational groups such as car manufacturers, competitive advantage depends on their ability not only to invent relevant products that find customers in local markets, but also to deploy them rapidly at the global level, harnessing economies of scale that a startup, however innovative, cannot achieve. How then to combine local adaptation of innovations with effective global deployment?

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research.

This book focuses on the significant role of West African consumers in the development of the global economy. It explores their demand for Indian cotton textiles and how their consumption shaped patterns of global trade, influencing economies and businesses from Western Europe to South Asia. In turn, the book examines how cotton textile production in southern India responded to this demand. Through this perspective of a south-south economic history, the study foregrounds African agency and considers the lasting impact on production and exports in South Asia. It also considers how European commercial and imperial expansion provided a complex web of networks, linking West African consumers and Indian weavers. Crucially, it demonstrates the emergence of the modern global economy.

This book is available as open access through the Bloomsbury Open Access programme and is available on www.bloomsburycollections.com. It is funded by the University of Otago, New Zealand. Farming Inside Invisible Worlds argues that the farm is a key player in the creation and stabilisation of political, economic and ecological power-particularly in colonised landscapes like New Zealand, America and Australia. The book reviews and rejects the way that farms are characterised in orthodox economics and agricultural science and then shows how re-centring the farm using the theoretical idea of political ontology can transform the way we understand the power of farming. Starting with the colonial history of farms in New Zealand, Hugh Campbell goes on to describe the rise of modernist farming and its often hidden political, racial and ecological effects. He concludes with an examination of alternative ways to farm in New Zealand, showing how the prior histories of colonisation and modernisation reveal important ways to farm differently in post-colonial worlds. Hugh Campbell's book has wide-ranging implications for understanding the role farms play in both our food systems and landscapes, and is an exciting new addition to food studies.

There has been a global rise in the incidence of chronic illnesses, which may be partially attributed to the lengthening of the average human lifespan. Functional foods and nutraceuticals have a potential role to play in the development and maintenance of health. They can assist the body in its battle against inflammation and chronic illnesses. Molecular Mechanisms of Action of Functional Foods and Nutraceuticals for Chronic Diseases addresses the effects and mechanism of functional foods in relation to chronic diseases such as obesity, cardiovascular diseases, diabetes, cancer, etc. This volume, like the companion Applications of Functional Foods and Nutraceuticals for Chronic Diseases, inspires new thought processes and a paradigm shift in research and development. Key Features: Discusses the molecular mechanism of action, the range of toxicities exerted by these food components for functional foods for addressing chronic conditions Enhances scientists and industrial personnel knowledge of functional foods and in the management of chronic diseases Presents research on the role of functional foods/nutraceuticals in preventing and treating chronic diseases through epigenetic modulation. Explores various subjects such as epigenetics, immunological, metabolic, technological and neurodenerative aspects affected by functional foods in chronic diseases The world's leading wellness centers for chronic diseases are using functional foods and nutraceuticals in their practice and discovering their useful applications, and this second of two related books is another great reference for practitioners, scientists, and clinicians in the management of chronic diseases. Contributors hail from different geographical locations around the world and have many years of research and scholarly experience in functional foods, nutraceuticals, and biology.

The Spring Electric is a lower priced electrical vehicle from The Renault Group. It is the result of an impossible project that was a breakthrough in cultural innovation. The development of the Spring brought together a French company, a Japanese partner, an Indian project, and a Chinese developer to deliver a car for the European market. The Innovation Odyssey: Lessons from an Impossible Project examines four key issues central to this vehicle's development: The nature of the automotive industry itself and the actors involved in these "societal" innovations. The movement toward the electrification of vehicles is inseparable from public policies aimed at reducing carbon emissions. Without substantial subsidies or rigorous bans on internal combustion engine vehicles (ICEVs), the electric vehicle (EV) would not be developed. It is these public policies that create the conditions for an electrified vehicle market. Electrification is thus a three-way game, in which public actors play a central role alongside suppliers and customers. Therefore, an analysis of these policies is essential to understand manufacturers' strategies in this area. What are the differences between these policies? Do they introduce regional competitive advantages? How do firms in the globalized automotive sector adapt to or take advantage of these differences? How can they combine local adaptation. Product strategy. To what extent should this technological breakthrough at the heart of the car be associated with a more profound break in the definition of the automobile product? Is the answer an electrification of the dominant ICEV design (and if so, how?) or a complete redefinition of the vehicle? International cooperation. Automotive design is largely concentrated in the technical centers of the parent companies: Detroit, Guyancourt, Wolfsburg, Yokohama. How can the design processes and the European and Chinese skills and know-how be combined in a project designed far from the traditional European or Japanese bases and under time constraints? Can this original form of design inspire new forms of international cooperation, and under what conditions? Globalized innovation strategies. For multinational groups such as car manufacturers, competitive advantage depends on their ability not only to invent relevant products that find customers in local markets, but also to deploy them rapidly at the global level, harnessing economies of scale that a startup, however innovative, cannot achieve. How then to combine local adaptation of innovations with effective global deployment?

Overcoming Obstacles in Drug Discovery and Development uses real-world case studies to illustrate how critical thinking and problem solving skills are applied in the discovery and development of drugs. It also shows how developing critical thinking to overcome issues plays an essential role in the process. Modern drug discovery and development is a highly complex undertaking that requires scientific and professional expertise to be successful. After the identification of a molecular entity for treating a medical condition, challenges inevitably arise during the subsequent development to understand and characterize the biological profile; feedback from scientists is used to fine-tune the molecular entity to obtain an effective and safe product. In this process, the discovery team may identify unexpected safety issues and new medical disorders for treatment by the molecular entity. Invariably inherent in this complex undertaking are miscues, mistakes, and unexpected problems that can derail development and throw timetables into disarray, potentially leading to failure in the development of a medically useful drug. Addressing critical unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills. Overcoming Obstacles in Drug Discovery and Development will be essential to young scientists to help learn the skills to successfully face challenges, learn from mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from the case studies of successful and unsuccessful drug development.

India is the largest provider of generic drugs globally. The Indian pharmaceutical sector supplies over 50 per cent of the global demand for various vaccines, and as a result, holds an important position in the global pharmaceutical sector. This book is a comprehensive study of pharmaceutical marketing management in the Indian context and similar growth markets. The book introduces the fast-paced and multi-faceted discipline of pharmaceutical marketing management through an in-depth discussion on the genesis and evolution of its marketing concept. Combining theory and practice, it offers a strategic approach to pharmaceutical marketing from an organisational and business perspective and explicates the practical applications of it. Richly supported by case studies, the book brings together fresh perspectives and approaches equally useful for students and professionals. This book will be of interest to academicians, advanced students, and practitioners of pharmaceutical marketing and pharmaceutical management. It will also be beneficial to those interested in business strategy, decision making, and international marketing.

This fourth volume in the series presents various sustainable approaches in the textile and fashion sector with a focus on manufacturing processes and chemicals. Sustainability is one of the important aspects in today's industrial context, which is followed by every industrial sector with no exception to textiles and fashion. Sustainability and strict adherence to the principles of sustainability has become as one of the essential needs again for any industrial sector including textiles and fashion. There are countless measures in terms of various approaches to make the textiles and fashion sector sustainable. These measures, but not limited to, ranging from innovating and implementing new fibres and raw materials, introducing innovative manufacturing methods, chemicals, processes to focus on all the possible stages of a textile product's life cycle from cradle to grave. These approaches include making the textiles and fashion sector circular and also development of new products from sustainable raw materials/processes or combination of both.

Nutraceutical encapsulation envelopes protection of products from oxidative damage, controlled delivery of nanoencapsulated nutraceuticals and improved nutraceutical bioavailability as well as biological action. It is a promising technique to ensure the stabilization of such labile compounds and to protect the core ingredients from premature reactions and interactions In a comprehensive manner, the Handbook of Nanoencapsulation: Preparation, Characterization, Delivery and Safety of Nutraceutical Nanocomposites presents various nanosystems/nanocarriers, physical and chemical techniques used in encapsulation of various nutraceuticals, and the targeted delivery of various significant nutraceuticals. This book bridges the gap between academia and research as it encompasses the ubiquitous applications of nanoencapsulation technique used on significant nutraceuticals derived from plants, animals as well as microalgae. Key Features: Provides a quick and easy access to major plant, animal and microalgae derived nutraceutical ingredients Discusses nanoencapsulation techniques for protection and targeted release of various food bioactive ingredients. Covers safety, bioaccessibility and multiple applications of nanoencapsulated nutraceuticals in the food industry Unveiling pivotal aspects of nanoencapsulation of significant nutraceuticals, this book is a valuable resource for researchers, food toxicologists, food scientists, nutritionists, and scientists in medicinal research.

This book provides extensive insights and analysis into pricing models for autonomous manufacturing. Taking a cost engineering approach, it shows how businesses facing technological change can provide visibility to pricing sensitivity and maximize price, and profit in every transaction. The book pulls together the many elements of cost engineering; cost estimation, cost control, business planning and management, profitability analysis, cost risk analysis and project management, planning, and scheduling, and considers the many different approaches and methods for estimating or assessing costs. It aims to help companies with decision making, cost management, and budgeting with respect to product development, and highlights the importance of cost estimation during the early stages of product development. A discussion of appropriate pricing models is also included to determine the most effective course for handling operational costs in autonomous manufacturing systems in order to create a more productive and profitable system. Cost Engineering and Pricing in Autonomous Manufacturing Systems will provide new insights for researchers and students, as well as industrial practitioners interested in applied models which can be employed and implemented in real cases.

This book provides comprehensive information on all aspects of consumer affective testing, including principles, application and implementation of consumer affective tests, data collection, statistical analysis, and interpretation of results. New approaches not previously covered in the literature include: 1) methodologies for testing of young children and the elderly and issues related to testing with individuals in these age groups, 2) an in-depth discussion of the development and maintenance of a consumer database, 3) qualitative consumer research methods, 4) simulated supermarket setting tests, and 5) use of mobile laboratory in consumer tests.

Trail-blazing social entrepreneurs are tackling the world's most pressing problems that government, business, or charity have failed to solve. They are creating businesses with a primary mission of social change. Scott Boyer is one such social entrepreneur. This 28-year veteran of Big Pharma left a six-figure salary to start OWP Pharmaceuticals and the ROW Foundation. This commercial business and non-profit organization exist in a symbiotic relationship we call a "tandem hybrid social enterprise." This model combines a multimillion dollar business with a foundation that's on track to become the largest funder of projects serving people with epilepsy and associated psychiatric disorders in the world. The tandem hybrid incorporates the principles learned by Scott and others for building a truly unique social enterprise from the ground up; one that is: Driven by a compelling social mission Financed by commercial success Structured to retain control Scalable and sustainable for the long haul Powering Social Enterprises With Profit And Purpose offers a detailed blueprint that has proven commercially and philanthropically successful and that can be replicated in most business sectors.