Medicinal chemistry and pharmacology are closely associated fields, and the use of natural products for their medicinal properties is ever-growing. The study of drugs from natural products and their effects on the living body are explored in this volume. The book looks into the research, discovery, and characterization of chemicals that exhibit biological effects. Providing an informative compilation of research, valuable case studies, and reviews of existing literature in the area, the book focuses on the ethnobotanical uses of natural products and phytochemicals for health care, including applications for diabetes, ulcers, wound healing, chronic alcoholism, hemorrhoidal treatment, cancer mitigation, pain management, immunotherapy, and more.

The pharmaceutical industry is one of today's most dynamic and complex industries, involving commercialization of cutting-edge scientific research, a huge web of stakeholders (from investors to doctors), multi-stage supply chains, fierce competition in the race to market, and a challenging regulatory environment. The stakes are high, with each new product raising the prospect of spectacular success-or failure. Worldwide revenues are approaching $1 trillion; in the U.S. alone, marketing for pharmaceutical products is, itself, a multi-billion dollar industry. In this volume, the editors showcase contributions from experts around the world to capture the state of the art in research, analysis, and practice, and covering the full spectrum of topics relating to innovation and marketing, including R&D, promotion, pricing, branding, competitive strategy, and portfolio management. Chapters include such features as: * An extensive literature review, including coverage of research from fields other than marketing * an overview of how practitioners have addressed the topic * introduction of relevant analytical tools, such as statistics and ethnographic studies * suggestions for further research by scholars and students The result is a comprehensive, state-of-the-art resource that will be of interest to researchers, policymakers, and practitioners, alike.

In the past, company success was typically measured by financial indicators. Lately though, non-financial measures such as employee morale have become popular. Although there are approaches that look into quantitative and qualitative performance measures affecting company success, none of them characterize it in a holistic way, combining all the critical performance measures. This book presents a multifaceted approach that prepares engineers and future organizational leaders/managers to measure, monitor, and predict company success in a more meaningful way.

Originally published in 1989 Defence Industries presents a worldwide survey of defence industries. It argues that modern weapon systems and electronic warfare have led to the transition of the military-industrial enterprise into a multifaceted entity where electronics production is the key. It analyses the extent of defence industries, showing that large portions of the aerospace, shipbuilding, motor vehicle and electronics industries are devoted to defence and discusses where the defence industries are located. It examines the differences in government policies, contrasting the superpowers, with newly industrialised countries.

Since 2008, while the global automotive manufacturing has been faltering, the Chinese auto industry has been swiftly transformed into the largest producer in the world. The growth of the Chinese automakers is a close reflection of China's powerful manufacturing economy, and Geely Auto is one such best example. This book closely examines the rise of Geely as a privately-owned automaker in China. From its humble beginning as a refrigerator component maker and motorcycle manufacturer in the late twentieth century, Geely has grown to become not only a top selling national brand in China, the largest auto market in the world, but also a significant player in the global automotive industry. The book studies Geely's successful acquisition of Volvo, within a long-term framework of asset-seeking foreign direct investment, and then further investigates its recent strategic initiatives with Daimler, London Taxi, PROTON and Lotus. The book reveals how the little-known carmaker is worth close examination, via its product development, organizational dynamics, corporate culture, brand development, talent and cross-cultural management strategies, as well as the entrepreneurship of its visionary founder Shufu Li. From catching up in technology to a leader in product, service and business model innovations, Geely has driven out as a new Chinese automaker on the world stage. Facing challenges in clean energy and Internet of Things, artificial intelligence, new user's experience towards smart and mobility solution, Geely will continue to play an increasingly important role in the globalization age of the twenty-first century.

Sustainable Production and Logistics: Modeling and Analysis Subject Guide: Engineering - Industrial & Manufacturing This book presents issues faced by planners of production and distribution operations in terms of smart manufacturing and sustainability, using efficient quantitative techniques in a variety of decision-making situations. Addressing the state-of-the-art of the smart and sustainable sides of production and distribution planning operations, it highlights how a current issue can be effectively approached and what particular quantitative technique can be used. The book goes on to provide a foundation in the new and fast-growing digital journey, and includes logistics 4.0 inside Industry 4.0, along with case studies. The information in this book is useful worldwide, especially in the Americas, Europe, Turkey, and Japan. It is written for academicians, researchers, practitioners, and students.

Closed loop supply chains and their management have become mandatory for firms to stay competitive and profitable. This book provides insights into designing supply chain networks by understanding and incorporating key return parameters into the network design, which will affect profitability. The book discusses how customer categories and their acceptance behavior are incorporated into the network design. It also shows how to analyze the interaction of parameters on supply chain network design and profitability, offers modeling framework for incorporating uncertainties in the return product parameters, and shows how to design a robust network. Invaluable for managers in designing a sustainable, robust, and profitable supply chain network and ideal for managers, practitioners, and researchers in the area of supply chain network design and optimization.

Manufacturing, like other industries, is rising to the challenges imposed by aggressive consumer demands and the need for cost-effective processing that delivers quality in the fastest possible time. Fierce competition means that keeping abreast of new developments and applications in technology is essential if companies are to meet demands profitably and keep ahead of competitors. This book investigates the design and management of digital manufacturing and assembly systems for an efficient, flexible, and modular production of customized products using the I40 (industry 4.0)-enabling technologies. This book will also provide case studies covering modeling, simulation, and optimization. eBook includes color figures. Discusses how the advancement of data communication and storage through the Internet of Things (IoT) opens the possibilities of connecting sensors, robots, and devices Sheds light on how the human role in industry is decreasing due to the development of connected manufacturing floors, allowing them to take more control over the manufacturing processes, decisions, and even maintenance Covers the benefits from exploiting digital manufacturing, manufacturing enterprises, and what they expect to achieve Explains the important roles that modeling, simulation, and optimization play Investigates the design and management of digital manufacturing and assembly systems for an efficient, flexible, and modular production of customized products exploiting the I40 (industry 4.0)-enabling technologies

Food is a source of nourishment, a cause for celebration, an inducement to temptation, a means of influence, and signifies good health and well-being. Together with other life enhancing goods such as clean water, unpolluted air, adequate shelter and suitable clothing, food is a basic good which is necessary for human flourishing. In recent times, however, various environmental and social challenges have emerged, which are having a profound effect on both the natural world and built environment - such as climate change, feeding a growing world population, nutritional poverty and obesity. Consequently, whilst the relationships between producers, supermarkets, regulators and the individual have never been more important, they are becoming increasingly complicated. In the context of a variety of hard and soft law solutions, with a particular focus on corporate social responsibility (CSR), the authors explore the current relationship between all actors in the global food supply chain. Corporate Social Responsibility, Social Justice and the Global Food Supply Chain also provides a comprehensive and interdisciplinary response to current calls for reform in relation to social and environmental justice, and proposes an alternative approach to current CSR initiatives. This comprises an innovative multi-agency proposal, with the aim of achieving a truly responsible and sustainable food retail system. Because only by engaging in the widest possible participatory exercise and reflecting on the urban locale in novel, material and cultural ways, is it possible to uncover new directions in understanding, framing and tackling the modern phenomena of, for instance, food deserts, obesity, nutritional poverty and social injustice. Corporate Social Responsibility, Social Justice and the Global Food Supply Chain engages with a variety of disciplines, including, law, economics, management, marketing, retailing, politics, sociology, psychology, diet and nutrition, consumer behaviour, environmental studies and geography. It will be of interest to both practitioners and academics, including postgraduate students, social scientists and policy-makers.

Innovation is the lifeline of national development. This handbook is a collection of chapters that provide techniques and methodologies for achieving the transfer of defense-targeted science and technology development for general industrial applications. The handbook shows how to translate theory and ideas into practical applications. Experts from national defense institutions, government laboratories, business, and industry contributed chapters to this handbook. The handbook also serves as an archival guide for nations, communities, and businesses expecting to embark upon science and technology transfer to industry. Included are several domestic and international case examples of practical innovation. Since the dawn of history, nations have engrossed themselves in developing new tools, techniques, and methodologies to protect their geographical boundaries. From the crude implements used by prehistorical people to very modern technologies, the end game has been the same. That is, to protect the homeland. Even in times of peace, efforts must be made to develop new machinery, equipment, processes, and devices targeted for the protection of the nation. The emergence of organized nations and structured communities facilitated even more innovative techniques of national defense. Evolution, revolution, and innovation have defined human existence for millennia. From the Ice Age to the Stone Age, the Bronze Age, the Iron Age, and to the modern age, innovation, rudimentary as it may be in many cases, has determined how humans move from one stage to the next. This comprehensive handbook provides a clear guide on the nuances of initiating and actualizing innovation. Both the qualitative and quantitative aspects of innovation are covered in the handbook. Features: Uses a systems framework to zero in on science and technology transfer Focuses on leveraging technical developments in defense organizations for general societal applications Coalesces the transfer strategies collated from various sources and practical applications Represents a world-class diverse collection of science and technology development, utilization, and transfer Highlights a strategy for government, academia, and industry partnerships

There has been a great deal of progress in additive manufacturing (AM) during the past two decades and recent developments have been highlighted by many researchers. However, until now, there has been a limit to what is available for beginners in a step-by-step format, showcasing the different commercial AM technologies for field application. This book helps fill that gap. Additive Manufacturing: Applications and Innovations presents case studies of commonly used AM technologies with basic numerical problems for better understanding. It also includes hybrid processes and 4D printing applications, which currently are not offered in other AM books. Features Offers solved and unsolved problems in additive manufacturing Provides an understanding for additive manufacturing per international standards Includes case studies for better understanding of the individual processes Presents a review of specific technology highlights Introduces future research directions, mainly in 4D printing applications

In virtually every decision, a pharmaceutical executive considers some type of forecast. This process of predicting the future is crucial to many aspects of the company - from next month's production schedule, to market estimates for drugs in the next decade. The pharmaceutical forecaster needs to strike a delicate balance between over-engineering the forecast - including rafts of data and complex 'black box' equations that few stakeholders understand and even fewer buy into - and an overly simplistic approach that relies too heavily on anecdotal information and opinion. Art Cook's highly pragmatic guide explains the basis of a successful balanced forecast for products in development as well as currently marketed products. The author explores the pharmaceutical forecasting process; the varied tools and methods for new product and in-market forecasting; how they can be used to communicate market dynamics to the various stakeholders; and the strengths and weaknesses of different forecast approaches. The text is liberally illustrated with tables, diagrams and examples. The final extended case study provides the reader with an opportunity to test out their knowledge. Forecasting for the Pharmaceutical Industry is a definitive guide for forecasters as well as the multitude of decision makers and executives who rely on forecasts in their decision making.

Inventory Planning with Innovation: A Cost Focus discusses inventory planning concepts with major emphasis on innovation to reduce cost in a single volume. Provides an understanding of innovation efforts and linking it with inventory planning in reducing cost. Offers various factors influencing innovation efforts, knowledge of investment or expenditure that might be estimated before starting the innovation efforts, purchase inventory, and the manufacturing inventory. Covers important concepts including innovation efforts, strategic period, procurement inventory, total cost estimation, production inventory, related total cost planning, multiple products, multiple items procurements, and multiple items manufacture. This reference is primarily written for senior undergraduate, graduate students, and professionals in the field of industrial engineering, production engineering, and manufacturing science.

This book identifies factors of information system (IS) integration that influence supply chain agility and illustrates how IS integration can achieve greater supply chain agility. Also considering the consequent operational impacts that arise from IS-enabled supply chain agility, the author presents real-life examples through interviews and surveys to explore how IS integrations affect supply chain agility in the context of the Chinese automotive industry. The ability to swiftly respond to competitive challenges is a key element in industry 4.0 and organisations with agile supply chains are better prepared to respond to uncertainties and changes. This book develops and presents guidelines on the deployment of information system integration in order to achieve efficient agile supply chains.

Food safety and hygiene is of critical importance to us all, yet, as periodic food crises in various countries each year show, we are all dependent on others in business and public regulation to ensure that the food we consume in the retailing and hospitality sectors is safe. Bridget Hutter considers the understandings of risk and regulation held by those in business and considers the compliance pressures on managers and owners, and how these relate to understandings of risk and uncertainty. Using data from an in-depth case study of the food retail and catering sectors in the UK, the research investigates how business risk management practices are influenced by external pressures such as state regulation, consumers, insurance and the media and by pressures within business. The argument of the book is that food businesses in the UK are generally motivated to manage risk. They realize that good risk management aligns with good business practice. However, there are challenges for an industry that is highly segmented in terms of risk management capacity. The findings have implications for contemporary risk regulation in the increasingly number of countries that rely on self-regulation. Managing Food Safety and Hygiene will prove invaluable for academic researchers and students in risk regulation studies, business studies, food studies, organizational studies, social psychology, socio-legal studies, sociology, management, public administration and political science. In addition, the book will also appeal to practitioners specifically to senior policy makers, regulators and business risk managers charged with managing risk in diverse organizational settings, and across different functional jurisdictions. Contents: Preface Introduction: Setting the Scene 1. Risk Regulation and Business Part I: The Food Retail and Hospitality Industry and Risk 2. The Food Retail and Hospitality Industry in the UK: A Research Approach 3. The Food Industry and Risk: Official Data and Workplace Understandings Part II: Risk Regulation 4. State Governance of Food Safety and Food Hygiene: The Regulatory Regime and the Views of those in the Food Sector 5. Risk Regulation Beyond the State: Research Responses about Non-State Regulatory Influences 6. Business Risk Regulation: Inside the Business Organization Part III: Conclusions and Policy Implications 7. Conclusions and Policy Implications Appendix 1: Profile of Phase 2 Respondents Appendix 2: Phase 2 Questionnaires Appendix 3: Phase 3 Interview Schedule

Irina Goryacheva authors this volume titled Rapid Immunotests for Clinical, Food and Environmental Applications that is devoted to the latest research in the area of the construction and application of rapid immunotests with plasmonic and luminescent detection, with special attention paid to the achievements of nanotechnology in the areas of labels and solid supports creation.With close attention to the basic principles and the specific issues, considering the breadth of the field that the rapid tests may offer, the coverage of this book is by no means complete, keeping open space for challenge and research

Shipbuilding in the United Kingdom provides a systematic historical account of the British Shipbuilders Corporation, first looking at this major industry under private enterprise, then under state control, and finally back in private hands. The chapters trace the evolution of public policy regarding shipbuilding, ship repair, and large marine engine building through the tenures of radically different Labour and Conservative governments, and through the response of the board of the British Shipbuilders Corporation, trade unions, and local management also. The book benefits from comprehensive archival research and interviews from the 1990s with leading players in the industry, as well as politicians, shipbuilders, trade union leaders, and senior civil servants. This authoritative monograph is a valuable resource for advanced students and researchers across the fields of business history, economic history, industrial history, labour history, maritime history, and British history.

All over the world, vast research is in progress on the domain of Industry 4.0 and related techniques. Industry 4.0 is expected to have a very high impact on labor markets, global value chains, education, health, environment, and many social economic aspects. Industry 4.0 Interoperability, Analytics, Security, and Case Studies provides a deeper understanding of the drivers and enablers of Industry 4.0. It includes real case studies of various applications related to different fields, such as cyber physical systems (CPS), Internet of Things (IoT), cloud computing, machine learning, virtualization, decentralization, blockchain, fog computing, and many other related areas. Also discussed are interoperability, design, and implementation challenges. Researchers, academicians, and those working in industry around the globe will find this book of interest. FEATURES Provides an understanding of the drivers and enablers of Industry 4.0 Includes real case studies of various applications for different fields Discusses technologies such as cyber physical systems (CPS), Internet of Things (IoT), cloud computing, machine learning, virtualization, decentralization, blockchain, fog computing, and many other related areas Covers design, implementation challenges, and interoperability Offers detailed knowledge on Industry 4.0 and its underlying technologies, research challenges, solutions, and case studies

Chiral Organic Pollutants introduces readers to the growing challenges of chirality in synthetic chemicals. In this volume, contributors brilliantly summarize the characteristics of chiral pollutants to provide tools and techniques for effectively assessing their environmental and human health risks. Chapters cover recent research on the physicochemical properties, sources, exposure pathways, environmental fate, toxicity, and enantioselective analysis of chiral organic pollutants. Chiral Organic Pollutants also provides comprehensive discussions on the current trends in the synthesis and legislation of chiral chemicals. Key Features: Includes sampling and analytical methods for the enantioselective analysis of a wide array of chiral organic pollutants in food and the environment Summarizes recent research on the sources, fate, transport, and toxicity of chiral organic pollutants in the environment Critically examines the sources and pathways of chiral organic pollutants such as pesticides, pharmaceuticals, and flame retardants in food Includes a comprehensive discussion on current trends in the enantioselective synthesis and chiral switching of pesticides and pharmaceuticals Provides analysis of current national and international regulations of chiral synthetic chemicals The use of chiral synthetic chemicals such as pesticides, pharmaceuticals, personal care products, and halogenated flame retardants has significantly grown in the past 60 years. Hence, understanding the human and environmental health effects of chiral organic pollutants is crucial in the industry, academia, and policymaking. Chiral Organic Pollutants is an excellent textbook and reference for students, scientists, engineers, and policymakers interested in food quality, environmental pollution, chemical analysis, organic synthesis, and toxicology. Also available in the Food Analysis and Properties Series: Analysis of Nanoplastics and Microplastics in Food, edited by Leo. M.L. Nollet and Khwaja Salahuddin Siddiqi (ISBN: 9781138600188) Proteomics for Food Authentication, edited by Leo M.L. Nollet, and Semih OEtles (ISBN: 9780367205058) Mass Spectrometry Imaging in Food Analysis, edited by Leo M.L. Nollet (ISBN: 9781138370692) For a complete list of books in this series, please visit our website at: www.crcpress.com/Food-Analysis--Properties/book-series/CRCFOODANPRO

This book brings together the work of international economist, labour economists and sociologists in a far-reaching study of global production networks and the challenges they pose for developing country workers. A number of both empirical and theoretical questions are addressed and answers are provided by drawing on a variety of examples - from China to Mexico to South Africa to Eastern Europe. The studies show that globalized production creates a new set of challenges to economic development for entrepreneurs, workers, governments and international organizations. YILMAZ AKYUZ Tun Ismail Ali Chair in Monetary and Financial Economics, University of Malaya, Malaysia JENNIFER BAIR Assistant Professor of Sociology at Yale University, USA RADHIKA BALAKRISHNAN Associate Professor of Eonomics at Marymount Manhattan College, USA JANINE BERG Research Economist at the International Labor Organization in Geneva, Switzerland GUNSELI BERIK Associate Professor of Economics at the University of Utah, USA ANTHONY BLACK Associate Professor, School of Economics, University of Capetown, South Africa ELISSA BRAUNSTEIN Assistant Research Professor and Assistant Director of the Political Economy Resear

There is an important overlap between science and design. The most significant technological developments cannot be produced without designers to conceptualize them. By the same token, designers cannot do their job properly without a good understanding of the scientific or technical principles that are being developed within the product. Science in Design: Solidifying Design with Science and Technology reveals the significance of the essential yet understudied intersection of design and scientific academic research and encompasses technological development, scientific principles, and the point of overlap between science and design. Encourages readers to comprehend the role of science in all facets of design Discusses the fundamental involvement of science required for engineering and design irrespective of whether the design is from an individual, business, or social perspective Covers the ontology, characteristics, and application of science in major fields of design education and design research, with an introduction of emerging practices transforming sustainable growth through applied behavioral models Depicts the art and science of material selection using new design techniques and technology advances like augmented reality, AI, and decision-support toolkits This unique book will benefit scientists, technologists, and engineers, as well as designers and professionals, across a variety of industries dealing with scientific analysis of design research methodology, design lifecycle, and problem solving.

There is an important overlap between science and design. The most significant technological developments cannot be produced without designers to conceptualize them. By the same token, designers cannot do their job properly without a good understanding of the scientific or technical principles that are being developed within the product. Science in Design: Solidifying Design with Science and Technology reveals the significance of the essential yet understudied intersection of design and scientific academic research and encompasses technological development, scientific principles, and the point of overlap between science and design. Encourages readers to comprehend the role of science in all facets of design Discusses the fundamental involvement of science required for engineering and design irrespective of whether the design is from an individual, business, or social perspective Covers the ontology, characteristics, and application of science in major fields of design education and design research, with an introduction of emerging practices transforming sustainable growth through applied behavioral models Depicts the art and science of material selection using new design techniques and technology advances like augmented reality, AI, and decision-support toolkits This unique book will benefit scientists, technologists, and engineers, as well as designers and professionals, across a variety of industries dealing with scientific analysis of design research methodology, design lifecycle, and problem solving.

The book highlights the biotechnological advancement in the area of food adulterants and outlines the current state of art technologies in the detection of food adulterants using omics and nanobiotechnology. The book provides insights to the most recent innovations, trends, concerns, and challenges in food adulterants. It identifies key research topics and practical applications of modern cutting-edge technologies employed for detection of food adulterants including: expansion of food adulterants market, potential toxicity of food adulterants and the prevention of food adulteration act, cutting-edge technology for food adulterants detection, and biosensing and nanobiosensing based detection of food adulterants. There is need for new resources in omics technologies for the application of new nanobiotechnology. Biotechnological Approaches in Food Adulterants provides an overview of the contributions of food safety and the most up-to-date advances in omics and nanobiotechnology approaches to a diverse audience from postgraduate students to researchers in biochemical engineering, biotechnology, food technologist, environmental technologists, and pharmaceutical professionals.

Optimization and decision making are integral parts of any manufacturing process and management system. The objective of this book is to demonstrate the confluence of theory and applications of various types of multi-criteria decision making and optimization techniques with reference to textile manufacturing and management. Divided into twelve chapters, it discusses various multi-criteria decision-making methods such as AHP, TOPSIS, ELECTRE, and optimization techniques like linear programming, fuzzy linear programming, quadratic programming, in textile domain. Multi-objective optimization problems have been dealt with two approaches, namely desirability function and evolutionary algorithm. Key Features Exclusive title covering textiles and soft computing fields including optimization and decision making Discusses concepts of traditional and non-traditional optimization methods with textile examples Explores pertinent single-objective and multi-objective optimizations Provides MATLAB coding in the Appendix to solve various types of multi-criteria decision making and optimization problems Includes examples and case studies related to textile engineering and management

The study of pharmaceutical dosage forms has many connections to biological and medical sciences including physiology, biochemistry, pharmacology, pharmacotherapy, therapeutics, pharmacodynamics, pharmacokinetics, and pharmacognosy. Dictionary of Pharmaceutical Dosage Forms is a collection of terms and definitions prepared to assist healthcare practitioners and students as a companion or reference resource when reading notes and completing routine care. It can also provide reference material for hospital and medical staff, consultants, nursing instructors, and pharmaceutical science students. This first edition classifies and organizes the forms in an easily readable format, so readers will find it a quick and simple reference. Features Collects terms and definitions to assist healthcare practitioners and students as a companion or reference resource when reading notes and completing routine care Focuses on product dosage forms and includes supplementary information, providing readers, particularly pharmacy and medical students and professionals, insights into choices of dosage forms made during drug product development Offers information on the indications, contraindications, side effects, and more, for a given drug Classifies and organizes the forms in a readable format, providing a quick and simple reference