Explore the dramatic changes brought on by the new manufacturing technologies of Industry 4.0 In Smart Manufacturing, The Lean Six Sigma Way, Dr. Anthony Tarantino delivers an insightful and eye-opening exploration of the ways the Fourth Industrial Revolution is dramatically changing the way we manufacture products across the world and especially how it will revitalize manufacturing in North America and Europe. The author examines the role and impact of a variety of new Smart technologies including industrial IoT, computer vision, mobile/edge computing, 3D printing, robots, big data analytics, and the cloud. He demonstrates how to apply these new technologies to over 20 continuous improvement/Lean Six Sigma tools, greatly enhancing their effectiveness and ease of use. The book also discusses the role Smart technologies will play in improving: Career opportunities for women in manufacturing Cyber security, supply chain risk, and logistics resiliency Workplace health, safety, and security Life on the manufacturing floor Operational efficiencies and customer satisfaction Perfect for anyone involved in the manufacturing or distribution of products in the 21st century, Smart Manufacturing, The Lean Six Sigma Way belongs in the libraries of anyone interested in the intersection of technology, commerce, and physical manufacturing.

To the surprise of many, regionally embedded clusters of small to medium sized businesses have continued to exist in spite of industrialisation and mass production. While scholars have discovered that the advantages of embeddedness in terms of industrialisation were situated in interfirm cooperation and conflict resolving mechanisms, it is far less clear how changing historical circumstances on the world market, i.e. globalisation, affected such systems. Taking a look inside Leipzig, a capital of the global fur industry between 1870 and 1939 with its numerous highly specialised businesses, both in production as well as trade, World Market Transformation examines the robustness of district firms within the highly volatile international fur business. This book examines how firm embeddedness not only served to overcome challenges related to industrialisation, but also strengthened the abilities of cluster firms to deal with changing world market circumstances. World Market Transformation integrates the "interior-biased" research tradition on local business systems and industrial districts into the "exterior" fields of global and transnational history. It is demonstrated that the local business district not only emerged because of the expansion of international trade, but that district processes of interfirm cooperation also gave shape to the spatial distribution, conventions and structures of the very same world market. The analysis of embedded communities thus offers an important instrument to examine phenomena of economic globalisation, but also how such macro-economic developments have been shaped and actively constructed by local actors.

The Arado Flugzeugwerke devoted twenty years to making aviation history in Potsdam-Babelsberg. Within the pages of this book the reader will find the first comprehensive history of Arado, including many previously unpublished details about this little-known aviation company.

Appraising cancer as a major medical market in the 2010s, Wall Street investors placed their bets on single-technology treatment facilities costing $100-$300 million each. Critics inside medicine called the widely-publicized proton-center boom "crazy medicine and unsustainable public policy." There was no valid evidence, they claimed, that proton beams were more effective than less costly alternatives. But developers expected insurance to cover their centers' staggeringly high costs and debts. Was speculation like this new to health care? Cancer, Radiation Therapy, and the Market shows how the radiation therapy specialty in the United States (later called radiation oncology) coevolved with its device industry throughout the twentieth-century. Academic engineers and physicians acquired financing to develop increasingly powerful radiation devices, initiated companies to manufacture the devices competitively, and designed hospital and freestanding procedure units to utilize them. In the process, they incorporated market strategies into medical organization and practice. Although palliative benefits and striking tumor reductions fueled hopes of curing cancer, scientific research all too often found serious patient harm and disappointing beneficial impact on cancer survival. This thoroughly documented and provocative inquiry concludes that public health policy needs to re-evaluate market-driven high-tech medicine and build evidence-based health care systems.

As innovation moves from the lab to the market, a new research phase begins for the entrepreneur: the market research phase. Inspired by a new technology that can change the world, critical questions need to be addressed. Is there a market for my innovation? Who are my clients? What do they need? Is my innovation filling that gap in the market? Who are my competitors? How are they approaching the market? If these questions are unaswered, entrepreneurs meet potential investors or partners with only a basic understanding of their market. The objective of this book is to fill this gap. It is a practical manual that gives entrepreneurs real-world advice and tools to build a solid market model. The book provides tips, models and tools entrepreneurs can use to collect, interpret and present their market and integrate it into their business plan. What the entrepreneur learns in this book will help him throughout his journey. After going over the market research process, he will learn how to design and use a number of market research tools, and how to adapt them in a life science context. From building a web survey to preparing interviews to doing your own secondary research, this handbook will help him gain a comprehensive understanding of how to perform his own market research activities and how to analyze his data. Finally, a number of frameworks (such as the TAM-SAM-SOM as well as the KANO Model) are described so that he can efficiently share what he has learned, using models that simply yet effectively shares findings.

Surface engineering is considered an important aspect in the reduction of friction and wear. This reference text discusses a wide range of surface engineering technologies along with applications in a comprehensive manner. The book describes various methods in surface engineering technology with a thorough explanation of various aspects of each process that comes under this domain. Apart from an enhanced explanation of the process and its attributes, this book also gives insight into the types of materials, applications, and optimization of surface engineering techniques. It discusses important topics including surface engineering of the functionality of graded materials, materials characterization, processing of biomaterials, design, surface modification technologies and process control, smart manufacturing, artificial intelligence, and machine learning applications. The book: discusses computational and simulation analyses for better selection of process parameters covers optimizations of processes with state-of-the-art technologies discusses applications of surface engineering in medical, agricultural, architecture engineering, and allied sectors covers processing techniques of biomaterials in surface engineering The text is useful for senior undergraduate, graduate students, and academic researchers working in diverse areas such as industrial and production engineering, mechanical engineering, materials science, and manufacturing science. It covers a hybrid process for surface modification, modeling techniques, and issues in surface engineering.

International production networks in manufacturing, particularly in machinery industries, have rapidly developed over the last two decades, resulting in dramatic increases in intra-regional and intra-industry trade, providing a key source of regional growth, integration and development in East Asia. This book provides a better understanding on how to effectively further increase SME participation in East Asian production networks, and in doing so identifies key challenges and issues that they need to address. This book aims to not only fill the theory-practice gap, but also to lay solid foundations for designing national arrangements and a regional institutional frameworks to further encourage and support SME engagement and participation in regional and global production networks. The book contains several country case studies and by drawing upon individual country experiences, at various stages of economic development, this book demonstrates the varying difficulty faced by SMEs in ASEAN member countries attempting to participate in regional production networks and highlighting differences in needs and policy priorities. This book offers both a more focused theme on the assessment of globalization and a rather unique approach by focusing upon the particular importance of SMEs, and by utilizing micro-level data at the firm or plant level. Its policy insights and the richness and uniqueness of the empirical findings will make the book an invaluable contribution to understanding East Asian production networks.

From food punnets to credit cards, plastic facilitates every part of our daily lives. It has become central to processes of contemporary socio-material living. Universalised and abstracted, it is often treated as the passive object of political deliberations, or a problematic material demanding human management. But in what ways might a 'politics of plastics' deal with both its specific manifestation in particular artefacts and events, and its complex dispersed heterogeneity? Accumulation explores the vitality and complexity of plastic. This interdisciplinary collection focuses on how the presence and recalcitrance of plastic reveals the relational exchanges across human and synthetic materialities. It captures multiplicity by engaging with the processual materialities or plasticity of plastic. Through a series of themed essays on plastic materialities, plastic economies, plastic bodies and new articulations of plastic, the editors and chapter authors examine specific aspects of plastic in action. How are multiple plastic realities enacted? What are their effects? This book will be of interest to students and scholars of sociology, human and cultural geography, environmental studies, consumption studies, science and technology studies, design, and political theory.

Emphasises an introduction and explanation of the practical methods used in reliability, and risk studies with a discussion of their uses and limitations Offers basic and advanced methods in reliability analysis that are commonly used in daily practice Provides methods that address unique topics such as dependent failure analysis, importance analysis, and analysis of repairable systems Presents a comprehensive overview of modern probabilistic life assessment methods such as Bayesian estimation, system reliability analysis, and human reliability Includes many ends of chapter problems, a tools website with computational codes, along with a solutions manual to support course adoptions

This book is an everything-included approach to understanding drones, creating an organization around using unmanned aircraft, and outlining the process of safety to protect that program. It is the first-of-a-kind safety-focused text book for unmanned aircraft operations, providing the reader with a required understanding of hazard identification, risk analysis, mitigation, and promotion. It enables the reader to speak the same language as any civil aviation authority, and gives them the toolset to create a safety risk management program for unmanned aircraft. The main items in this book break down into three categories. The first approach is understanding how the drone landscape has evolved over the last 40 years. From understanding the military components of UAS to the standards and regulations evolution, the reader garners a keen understanding of where we came from and why it matters for moving forward. The second approach is in understanding how safety risk management in aviation can be applied to drones, and how that fits into the regulatory and legislative environment internationally. Lastly, a brief synopsis of the community landscape for unmanned aircraft is outlined with interviews from important leaders and stakeholders in the marketplace. Drones fills a gap in resources within the unmanned aircraft world. It provides a robust understanding of drones, while giving the tools necessary to apply for a certificate of authorization, enabling more advanced flight operations for any company, and developing safety risk management tools for students and career professionals. It will be a mainstay in all safety program courses and will be a required tool for any and all individuals looking to operate safely and successfully in the United States.

Will the manufacturing industry in east-central Europe survive when the host countries join the European Union? This controversial book challenges the assumption, made by the European Commission, that industries in transitional economies should have little difficulty establishing and maintaining a competitive position after entry into the European Union. The analysis focuses on Hungary, Poland, the Czech Republic, Slovakia and the former east Germany. Issues discussed include: * changes in economic structures, the transformation of enterprises and financial restructuring * levels of competitiveness in the countries, the region and internationally * industrial policy in the region * levels and nature of investment * limits and sources of growth * integration into western Europe * dangers of over-hasty harmonization of macroeconomic conditions with the European Union The authors conclude that although the basic structures of a market economy are firmly established, the transition has not encouraged the development of more advanced industrial activities. They strongly suggest that there should be an active policy framework, based on international experience, specifically geared towards improving the international competitiveness of industry in east-central Europe.

Deep Stall applies a framework of strategic analysis to the Boeing Company. Boeing is the world's largest aerospace / defence company, with turnover in the region of US $60bn. The book examines the relative decline of Boeing in the civil aircraft market in relation to European manufacturer, Airbus. The aim of the book is to utilize the concept of strategic value to explain Boeing's decline. The authors define this concept as investment in people and technology to leverage future market success by developing innovative new products, arguing that Boeing has neglected strategic value in favour of shareholder value, defined in terms of short-term cash benefits. The rationale for the book exists both in the fact that the story in itself is interesting and also in the wider framework of analysis concerning the correct strategic approach for running a high technology business. The argument illustrates what can happen when quarterly returns become the predominant strategic rationale for a company. In the U.S. the business media (Economist, Forbes, Fortune, and Business Week etc) are now focusing on the question of Boeing's decline and the major implications for the U.S. national interest. Boeing is one of the jewels in the US technology crown, but today U.S. jobs and capability are being exported abroad, with most of its aircraft program work based in Asia. This is a hot topic in the US which explains why the business media are now so interested in this question. The book sits squarely in the centre of this debate. Deep Stall concludes with a brief analysis of the recent fight-back that has been evident in Boeing's fortunes and the successful campaign to sell the new 787. The authors probe the question of whether Airbus or Boeing is likely to dominate in the next ten or fifteen years.

Businesses that produce bioscience products--gene tests and therapies, pharmaceuticals, vaccines, and medical devices--are regularly confronted with ethical issues concerning these technologies. Conflicts exist between those who support advancements in bioscience and those who fear the consequences of unfettered scientific license. As the debate surrounding bioscience grows, it will be increasingly important for business managers to consider the larger consequences of their work.
This groundbreaking book follows industry research, development, and marketing of medical and bioscience products across a variety of fields, including biotechnology, pharmaceuticals, and bio-agriculture. Compelling and current case studies highlight the ethical decisions business managers frequently face. With the increasing visibility and public expectation placed on businesses in this sector, managers need to understand the ethical and social issues. This book addresses that need and provides a framework for incorporating ethical analysis in business decision making.

Strictly off limits to the public, Plum Island is home to virginal beaches, cliffs, forests, ponds -- and the deadliest germs that have ever roamed the planet. "Lab 257" blows the lid off the stunning true nature and checkered history of Plum Island. It shows that the seemingly bucolic island in the shadow of New York City is a ticking biological time bomb that none of us can safely ignore.

Based on declassified government documents, in-depth interviews, and access to Plum Island itself, this is an eye-opening, suspenseful account of a federal government germ laboratory gone terribly wrong. For the first time, "Lab 257" takes you deep inside this secret world and presents startling revelations on virus outbreaks, biological meltdowns, infected workers, the periodic flushing of contaminated raw sewage into area waters, and the insidious connections between Plum Island, Lyme disease, and the deadly West Nile virus. The book also probes what's in store for Plum Island's new owner, the Department of Homeland Security, in this age of bioterrorism.

"Lab 257" is a call to action for those concerned with protecting present and future generations from preventable biological catastrophes.

Textiles have been a highly valued and central part of the politics of human societies across culture divides and over millennia. The economy of textiles provides insight into the fabric of social relations, local and global politics, and diverse ideologies. Textiles are a material element of society that fosters the study of continuities and disjunctions in the economic and social realities of past and present societies. From stick-loom weaving to transnational factories, the production of cloth and its transformation into clothing and other woven goods offers a way to study the linkages between economics and politics. The volume is oriented around a number of themes: textile production, textiles as trade goods, textiles as symbols, textiles in tourism, and textiles in the transnational processes. Textile Economies appeals to a broad range of scholars interested in the intersection of material culture, political economy, and globalization, such as archaeologists, cultural anthropologists, economists, museum curators, and historians.

A comprehensive presentation of wicking models developed in academia and industry, Wicking in Porous Materials: Traditional and Modern Modeling Approaches contains some of the most important approaches and methods available, from the traditional Washburn-type models to the latest Lattice-Boltzmann approaches developed during the last few years. It provides a sound conceptual framework for learning the science behind different mathematical models while at the same time being aware of the practical issues of model validation as well as measurement of important properties and parameters associated with various models. Top experts in the field reveal the secrets of their wicking models. The chapters cover the following topics: Wetting and wettability Darcy's law for single- and multi-phase flows Traditional capillary models, such as the Washburn-equation based approaches Unsaturated-flow based methodologies (Richard's Equation) Sharp-front (plug-flow) type approaches using Darcy's law Pore network models for wicking after including various micro-scale fluid-flow phenomena Studying the effect of evaporation on wicking using pore network models Fractal-based methods Modeling methods based on mixture theory Lattice-Boltzmann method for modeling wicking in small scales Modeling wicking in swelling and non-rigid porous media This extensive look at the modeling of porous media compares various methods and treats traditional topics as well as modern technologies. It emphasizes experimental validation of modeling approaches as well as experimental determination of model parameters. Matching models to particular media, the book provides guidance on what models to use and how to use them.

When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult. Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed reviews of its various stages and contributing factors as well as relevant regulatory pathways and pre- and post-approval issues.

The global pharmaceutical industry is currently estimated to be worth $1 trillion. Contributors chart the rise of scientific marketing within the industry from 1920-1980. This is the first comprehensive study into pharmaceutical marketing, demonstrating that many new techniques were actually developed in Europe before being exported to America.

Many argue that the sole viable future for the automobile industry - indeed for all industry - is the adoption of `lean production' as an organizational model. One Best Way? brings together the research of academic specialists in the automobile industry who have analysed the evolution of 15 major Asian, North American, and European companies in terms of their technological, organizational, commercial and social `trajectories'. They look closely at the evidence for `one best way' and argue that it is more useful to assess the distinctive challenges and `trajectories' that companies have pursued as they try to optimize their profit-making capacities. The book present detailed descriptions of the major producers around the world in three sections: Asia: Toyota, Nissan, Honda, Mitsubishi, Hyundai North America: General Motors, Ford, Chrysler Europe: Peugeot, Renault, Rover, Mercedes, Volvo, Lada The book will be essential reading and reference for academics, researchers, and analysts worldwide wanting to track the course of the automobile industry and assess the merits of `lean production'.

Plants require nutrients in order to grow, develop and complete their life cycle. Mineral fertilizers, and hence the fertilizer industry, constitute one of the most imp- tant keys to the world food supplies. There is growing concern about the safety and quality of food. Carbon, hydrogen and oxygen, which, together with nitrogen, form the structural matter in plants, are freely available from air and water. Nitrogen, phosphorus and potassium, on the other hand, may not be present in quantities or forms sufficient to support plant growth. In this case, the absence of these nut- ents constitutes a limiting factor. The supply of nutrients to the plants should be balanced in order to maximise the efficiency of the individual nutrients so that these meet the needs of the particular crop and soil type. For example, it should be noted that EU-wide regulations are not designed to govern the specific details of mineral fertilizer use. Although plants receive a natural supply of nitrogen, phosphorus and potassium from organic matter and soil minerals, this is not usually sufficient to satisfy the demands of crop plants. The supply of nutrients must therefore be supplemented with fertilizers, both to meet the requirements of crops during periods of plant growth and to replenish soil reserves after the crop has been harvested. Pesticides are important in modern farming and will remain indispensable for the foreseeable future.

The mood of the international grain market changed remarkably in the decade before this book was originally published in 1986. In the early 1970s, which were years of buoyancy and high prices, the concern was with feeding the starving millions and subsequently, in the United states, with the use of the grain embargo weapon to put pressure on the Soviet Union. In the mid-1980s, after a long period in which the recession kept prices down, the climate was much gloomier. The book considers the state of the major supplier countries and their particular problems. It charts the changes in the market and discusses major issues of international concern. It concludes by surveying prospects for the market.

In this timely title Professor Arti Rai brings together a wide range of articles that reveal the important role of intellectual property law in the formation and development of the dynamic and economically significant biotechnology industry. The collection encompasses theoretical articles that present principles of patent economics important to the industry, articles that discuss the patent law doctrines most relevant to biotechnology and empirical studies on the 'real world' effects of patents and secrecy. These are resonant issues in an ever-expanding field, and will establish this book as an essential reference point for lawyers, researchers and students.

Coffee Culture: Local experiences, Global Connections explores coffee as (1) a major commodity that shapes the lives of millions of people; (2) a product with a dramatic history; (3) a beverage with multiple meanings and uses (energizer, comfort food, addiction, flavouring, and confection); (4) an inspiration for humor and cultural critique; (5) a crop that can help protect biodiversity yet also threaten the environment; (6) a health risk and a health food; and (7) a focus of alternative trade efforts. This book presents coffee as a commodity that ties the world together, from the coffee producers and pickers who tend the plantations in tropical nations, to the middlemen and processors, to the consumers who drink coffee without ever having to think about how the drink reached their hands.

Coffee: A Comprehensive Guide to the Bean, the Beverage, and the Industry offers a definitive guide to the many rich dimensions of the bean and the beverage around the world. Leading experts from business and academia consider coffee's history, global spread, cultivation, preparation, marketing, and the environmental and social issues surrounding it today. They discuss, for example, the impact of globalization; the many definitions of organic, direct trade, and fair trade; the health of female farmers; the relationships among shade, birds, and coffee; roasting as an art and a science; and where profits are made in the commodity chain. Drawing on interviews and the lives of people working in the business-from pickers and roasters to coffee bar owners and consumers-this book brings a compelling human side to the story. The authors avoid romanticizing or demonizing any group in the business. They consider basic but widely misunderstood issues such as who adds value to the bean, the constraints of peasant life, and the impact of climate change. Moving beyond simple answers, they represent various participants in the supply chain and a range of opinions about problems and suggested solutions in the industry. Coffee offers a multidimensional examination of a deceptively everyday but extremely complex commodity that remains at the center of many millions of lives. Tracing coffee's journey from field to cup, this handbook to one of the world's favorite beverages is an essential guide for professionals, coffee lovers, and students alike. Contributions by: Sarah Allen, Jonathan D. Baker, Peter S. Baker, Jonathan Wesley Bell, Clare Benfield, H. C. "Skip" Bittenbender, Connie Blumhardt, Willem Boot, Carlos H. J. Brando, August Burns, Luis Alberto Cuellar, Olga Cuellar, Kenneth Davids, Jim Fadden, Elijah K. Gichuru, Jeremy Haggar, Andrew Hetzel, George Howell, Juliana Jaramillo, Phyllis Johnson, Lawrence W. Jones, Alf Kramer, Ted Lingle, Stuart McCook, Michelle Craig McDonald, Sunalini Menon, Jonathan Morris, Joan Obra, Price Peterson, Rick Peyser, Sergii Reminny, Paul Rice, Robert Rice, Carlos Saenz, Vincenzo Sandalj, Jinap Selamat, Colin Smith, Shawn Steiman, Robert W. Thurston, Steven Topik, Tatsushi Ueshima, Camilla C. Valeur, Geoff Watts, and Britta Zeitemann

Weaving as a subject is an integral part of any textile engineering/technology program, the others being fibre manufacturing, yarn manufacturing and textile chemical processing. This book amalgamates both the compartments (preparatory processes and the loom mechanism) of weaving technology and presents a holistic picture. The machine descriptions are presented from the viewpoint of principles and no attempt has been made to make them exhaustive by incorporating various models or variants. The mathematical relations among various parameters have been derived starting from the first principles and each chapter concludes with solved numerical examples.