This invaluable volume serves as a guide to up-to-the-minute techniques for the discovery and evaluation of pharmacologically active compounds for therapeutic development. Focusing on practical applications, provided by expert practitioners from both industry and academic research laboratories, Advances in Drug Discovery Techniques covers rational drug design, high-throughput screening and genetic approaches to drug discovery. Moreover, chapters also focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. Typical screening studies and their link to robotics and informatics are also presented in detail, together with an overview of current progress within antisense therapeutics. Overall, this book will be an excellent reference source for all individuals interested in making sense of the rapid changes in drug discovery that result from developments in molecular biology, robotics and informatics.

The principles of lean manufacturing increasing efficiency, reducing waste, lowering costs and improving control may be applied to any industry. However, the food industry is unique, and creates unique demands. The political, social and economic importance of food is unrivalled by any other form of produce, as is the scrutiny to which the manufacture of food is subjected. For the food industry, lean manufacturing is not simply a cost-saving strategy, but is directly linked to issues of sustainability, the environment, ethics and public accountability. Handbook of Lean Manufacturing in the Food Industry is a major new source of information and ideas for those working in food manufacturing. Offering a fresh and modern perspective on best practice, it points the way to fewer breakdowns, reduced quality faults, improved teamwork and increased profits. With a focus on operations management and new process development, the book is accessible and easy to read, and is complemented by a wealth of practical examples drawn from industry. The author s conversational style and questioning approach will be invaluable to food manufacturers who are seeking solutions to fundamental issues. The book is directed at those who are working in food manufacturing or the wider food industry, particularly factory operations managers and training teams who are looking for resources to help with lean manufacturing implementations. Others in the supply chain, from producers to retailers, will also find it invaluable. The book is a clear and timely introduction for students and lecturers in food science and technology who want to access the reality of lean manufacturing as well as the theory.

This book presents a series of studies analyzing critical factors that promote and constrain textile & clothing (T&C) production and trade in the Belt & Road (B&R) countries, and forces that drive the restructuring and transforming of global T&C supply chain and operations in the B&R context. The book also offers insights into the challenges and opportunities for T&C manufacturing in B&R countries through interviews with T&C experts, and also examines how Hong Kong can strengthen its "super-connector" role by facilitating sustainable trade and development in the T&C industries, as well as discussion on the impact of global trade wars on T&C trade. In the studies presented in this book, they offer topics ranging from the macro-economy, international business environment and strategies, logistics and supply chain, policy changes, to sustainability. The studies offer descriptive, theoretical and empirical analyses that explore T&C business and management related opportunities and challenges that are derived from the Belt and Road Initiative (BRI). Econometric analysis with the gravity model is applied to T&C trade and extended to cover other areas that have not been considered in previous studies, such as production costs, export supply chain costs, technologies, demographical factors, and factors related to the business environment and policies, including qualitative variables. Studies using in-depth interviews and linear regression analysis are also present to explore new factors for T&C trade and production relocation to B&R countries.

Nanotechnology has been emerging as an important tool in the nutraceutical and food industries to improve the overall quality of life. Nanotechnology has established a new horizon by bestowing modified properties on nanomaterials and applying them to the production of nanoformulations, nutritional supplements, and the food industry. The Handbook of Nanotechnology in Nutraceuticals highlights the impact of nanotechnology on the food industries. The book focuses on the application of nanotechnology in nutraceuticals and the food industry to improve the overall quality of life. The book also addresses some important applications of nano-nutraceuticals in the treatment of different diseases, such as oxidative stress, cancer, neurodegenerative disorders, cardiovascular diseases, and so on. Features * Presents a scientometric approach to analyze the emergence of nano-nutraceuticals in cancer prevention and treatment * Examines various strategies employed to prepare nanocarrier systems, such as nanoparticles, nanostructure lipids, phospholipid-based nanocarriers, polysaccharide-based nanostructures, and metal nanoparticles * Discusses various regulatory issues related to nanotechnology and their application in different fields This book is a valuable reference for nanotechnologists, scientists, and researchers working in the field of food technology, food science, pharmaceuticals, and nutraceuticals.

This book addresses the issue of sustainability in the luxury industry, which has become a major topic of concern for brand managers, scholars, policy-makers, the media, and academia. Spanning 13 chapters, the authors provide insights from developed and developing countries, whilst at the same time exploring a variety of issues within sustainable luxury, the hidden value of secondhand, eco-luxury, circular economy principles and perceptions, ethical sourcing and eco-label strategies. All of which can be linked to the broader theme of SDG12: Responsible Production and Consumption. Thus, the book not only has a wide geographical scope but also brings together a collection of scholars spanning many disciplines such as marketing, management, textiles, fashion, economics, and digital media. Offering a combination of empirical and conceptual works, the book also provides important insights for future research enquiries.

Advances in Food and Nutrition Research, Volume 84 provides updated knowledge on nutrients in foods and how to avoid their deficiency, especially the essential nutrients that should be present in the diet to reduce disease risk and optimize health. The book provides the latest advances on the identification and characterization of emerging bioactive compounds with putative health benefits. Readers will find up-to-date information on food science, including raw materials, production, processing, distribution and consumption, with an emphasis on nutritional benefits and health effects. Specific sections in this new release include discussions on ethylcellulose oleogels, novel biosensors for the rapid detection of toxicants in foods, polyphenols and their interactions with other dietary compounds- implications for human health, protein hydrolysates and hypolipidemia, the effects of B-alanine supplementation on carnosine elevation and physiological performance, the effect of ultrasound technology on food and nutritional quality, modern procedures for removal of hazardous compounds from foods, the bioactive potential of Andean and Amazonian fruits, seeds and tubers, and more.

The 1980s car era had been brash and loud - but the 1990s that followed was markedly more sober, stylish and sophisticated. A period when safety and durability improved . . . even though insurance hikes, speed cameras and the introduction of the separate theory test made driving more of a challenge. Britpop bands battled in the charts as CD players became the ultimate in-car accessory. In the latest addition to this classic series, Giles Chapman investigates the newly nostalgic motoring decade of the 1990s, looking back in entertaining style over the induction of such memorable icons as the Peugeot 106 and 206, Fiat Punto, Jaguar XJ, Toyota RAV4, Subaru Impreza Turbo, Audi TT, TVR Chimaera and Ford Focus MkI.

British Tank Production and the War Economy, 1934-1945 explores the under-researched experiences of the British tank industry in the context of the pressures of war. Benjamin Coombs explores the various demands placed on British industry during the Second World War, looking at the political, military and strategy pressures involved. By comparing the British tank programme with the Canadian, American, Russian and Australian equivalents, this study offers an international perspective on this aspect of the war economy. Topics covered include the premature contraction of the tank programme and dependence on American armour, the supply of the Valentine tank to the Russian authorities and the ongoing employment of the tank in the postwar peacetime markets.

This book assesses developmental experience in different countries as well as British expansion following the industrial revolution from a developmental perspective. It explains why some nations are rich and others are poor, and discusses how manufacturing made economies flourish and spur economic development. It explains how today's governments can design and implement industrial policy, and how they can determine economically strategic sectors to break out of Low and Middle Income Traps. Closely linked to global trade and (im)balances, industrialization was never an accident. Industrialization explains how some countries experience export-led growth and others import-led slowdowns. Many confuse industrialization with the construction of factory buildings rather than a capacity and skill building process through certain stages. Industrial policy helps countries advance through those stages. Explaining technical concepts in understandable terms, the book discusses the capacity and limits of the developmental state in industrialization and in general in economic development, demonstrating how picking-the-winner type focused industrial policy has worked in different countries. It also discusses how industrial policy and science, technology and innovation policies should be sequenced for best results.

In the late fifteenth century, Burgundy was incorporated in the kingdom of France. This, coupled with the advent of Protestantism in the early sixteenth century, opened up new avenues for participation in public life by ordinary Burgundians and led to considerably greater interaction between the elites and the ordinary people. Mack Holt examines the relationship between the ruling and popular classes from Burgundy's re-incorporation into France in 1477 until the Lanturelu riot in Dijon in 1630, focusing on the local wine industry. Indeed, the vineyard workers were crucial in turning back the tide of Protestantism in the province until 1630 when, following royal attempts to reduce the level of popular participation in public affairs, Louis XIII tried to remove them from the city altogether. More than just a local study, this book shows how the popular classes often worked together with local elites to shape policies that affected them.

1) This is a comprehensive book on creative industries in India. 2) The book contains essays with recent data and multiple crucial case studies from across India. 3) This book will be of interest to departments of development studies, South Asian studies and cultural studies across UK.

In this anthology, editors Kym Anderson and Vicente Pinilla have gathered together some of the world's leading wine economists and economic historians to examine the development of national wine industries before and during the two waves of globalization. The empirically-based chapters analyze developments in all key wine-producing and consuming countries using a common methodology to explain long-term trends and cycles in wine production, consumption, and trade. The authors cover topics such as the role of new technologies, policies, and institutions, as well as exchange rate movements, international market developments, evolutions in grape varieties, and wine quality changes. The final chapter draws on an economic model of global wine markets, to project those markets to 2025 based on various assumptions about population and income growth, real exchange rates, and other factors. All authors of the book contributed to a unique global database of annual data back to the mid-nineteenth century which has been compiled by the book editors.

This book tells the fascinating story of the relationship of tobacco products to cancer, from the first discoveries to the present day cancer pandemic and regulatory activities. Although there are already excellent books and monographs on this topic, both in the popular press and as government summaries, none relate the scientific story at the level of non-specialist graduate and medical students, researchers, or educated popular science readers. In this book, with a primary focus on the United States, the editors - Stephen S Hecht and Dorothy K Hatsukami - bring together 24 renowned experts on the subject of tobacco and cancer to summarize specific aspects of this critical topic in relatively non-technical terms while also incorporating some personal insights related to the story of the discovery process. This highly authoritative book is also expected to be an excellent teaching tool and basis for a course for graduate and medical students on this important topic.

This book presents the findings of systematic research into the healthcare medicine management policies of China. In-depth comprehensive research has been carried out, targeting multiple issues of particular importance in healthcare medicine management, such as the purchasing, pricing, payment, usage, and the function of commercial healthcare insurance in medical payment. The book goes on to put forward policy advice regarding the aforementioned issues.

Discusses about 14 different spices and their salient features Presents the novel technologies used in the extraction, isolation and identification of bioactive compounds from spices Explores the utilization of spices as culinary use in food

Provides a comprehensive review of challenges and opportunities as related to the applications of big data, AI, and machine learning in the entire spectrum of drug R&D Discusses regulatory developments in leveraging big data and advanced analytics in drug review and approval Offers a balanced approach to data science organization build Presents real-world examples of AI-powered solutions to a host of issues in the lifecycle of drug development Affords sufficient context for each problem and provides detailed description of solutions suitable for practitioners with limited data science expertise

Discusses information related to chemistry of maize components Comprehensive information on physical and milling properties of maize Explains the structure, functional and antioxidant properties in maize flour Provides the latest scientific development in the modification of maize starch Explores maize based various food products and their storage Discusses maize protein, scenario and quality improvement through bio-fortification

1) This is a comprehensive book on creative industries in India. 2) The book contains essays with recent data and multiple crucial case studies from across India. 3) This book will be of interest to departments of development studies, South Asian studies and cultural studies across UK.

This book is an important and original account of life in the new lean production workplace - the car industry where it all began. It brings together the two emblematic features of the 20th century: a working class meant to topple the social order, and a product that largely provided the developmental model of that same order. This book is neither a retrospective assessment nor a prediction for the future: it reveals what has changed and what has remained the same, in a workplace that remains a major part of the makeup of our society.

Starch is one of the main staples in human food, its consumption having both positive and negative aspects. The exploration and exploitation of starches from alternative botanical sources has been increasing recently due to interest in the economic and social development of tropical and sub-tropical regional economies and in support of sustainability. The book reviews existing research on various aspects of starch, including physicochemical, nutritional and functional properties, plus applications in addition to foods. Emphasis is on the various physical and chemical modifications, which are aimed at improving the properties and applicability of starch. Key Features Analyzes the state of the art of the scientific and technological problems associated with starch Describes various applications of starch in foods Provides a broad view on the field of starch and starchy foods

Advances in Food Safety and Environmental Engineering is a compilation of selected papers from the 2022 4th International Conference on Food Safety and Environmental Engineering (FSEE 2022) and focuses on the research of food engineering and environmental engineering. The proceedings feature the most cutting-edge research directions and achievements related to health and environment. Subjects in these proceedings include: Food Safety and Health Food Nutrition Food Processing and Preservation Environmental Engineering and Technology Ecology and Ecosystem Management This collection of papers aims to promote food safety and environmental development, resource sharing, flexibility and high efficiency. An additional goal is to promote scientific information exchange globally between scientists from the best universities, research centers and high-tech companies.

We all know that as a nation our mental health is in crisis. But what most don't know is that a critical ingredient in this debate, and a crucial part of the solution - what we eat - is being ignored. Nutrition has more influence on what we feel, who we become and how we behave than we could ever have imagined. It affects everything from our decision-making to aggression and violence. Yet mental health disorders are overwhelmingly treated as 'mind' problems as if the physical brain - and how we feed it - is irrelevant. Someone suffering from depression is more likely to be asked about their relationship with their mother than their relationship with food. In this eye-opening and impassioned book, psychologist Kimberley Wilson draws on startling new research - as well as her own work in prisons, schools and hospitals around the country - to reveal the role of food and nutrients in brain development and mental health: from how the food a woman eats during pregnancy influences the size of her baby's brain, and hunger makes you mean; to how nutrient deficiencies change your personality. We must also recognise poor nutrition as a social injustice, with the poorest and most vulnerable being systematically ignored. We need to talk about what our food is doing to our brains. And we need decisive action, not over rehearsed soundbites and empty promises, from those in power - because if we don't, things can only get worse.

A 2017 Michigan Notable Book After World War II, the American automobile industry was reeling. Having spent years building tanks and airplanes for the army, the car companies would need years more to retool their production to meet the demands of the American public, for whom they had not made any cars since 1942.    And then in stepped Preston Tucker. This salesman extraordinaire from Ypsilanti, Michigan, had built race cars before the war, and had designed prototypes for the military during it. Now, gathering a group of brilliant automotive designers, engineers, and promoters, he announced the creation of a revolutionary new car: the Tucker '48, the first car in almost a decade to be built fresh from the ground up. Tucker's car would include ingenious advances in design and engineering that other car companies could not match. With a rear engine, rear-wheel drive, a safety-glass windshielf that would pop out in case of an accident, a padded dashboard, independent suspension, and automatic transmission, it would be more attractive and aerodynamic—and safer—than any other car on the road.    But as the public eagerly awaited Tucker's car of tomorrow, powerful forces in Washington were trying to bring him down. An SEC commissioner with close ties to Detroit's Big Three automakers deliberately leaked information about an investigation the agency was conducting, suggesting that Tucker was bilking investors with a massive fraud scheme. Headlines accused him a perpetrating a hoax and claimed that his cars weren't real and his factory was a sham.  In fact, the Tucker '48 sedan was genuine, and everyone who saw it was impressed by what this upstart carmaker had achieved. But the SEC's investigation had compounded the company's financial problems and management conflicts, and a superior product was not enough to keep Tucker's dream afloat.  Here, Steve Lehto tackles the story of Tucker's amazing rise and tragic fall, relying on a huge trove of documents that has been used by no other writer to date. It is the first comprehensive, authoritative account of Tucker's magnificent car and his battles with the government. And in this book, Lehto finally answers the questions automobile aficionados have wondered about for decades: Exactly how and why was the production of such an innovative car killed?