This three-volume set of Pharmaceutical Dosage Forms: Parenteral Medications is an authoritative, comprehensive reference work on the formulation and manufacture of parenteral dosage forms, effectively balancing theoretical considerations with the practical aspects of their development. As such, it is recommended for scientists and engineers in the pharmaceutical industry and academia, and will also serve as an excellent reference and training tool for regulatory scientists and quality assurance professionals. First published in 1984 (as two volumes) and then last revised in 1993 (when it grew to three volumes), this latest revision will address the plethora of changes in the science and considerable advances in the technology associated with these products and routes of administration. The third edition of this book maintains the features that made the last edition so popular but comprises several brand new chapters, revisions to all other chapters, as well as high quality illustrations. Volume three presents: * An in-depth discussion of regulatory requirements, quality assurance, risk assessment and mitigation, and extractables/leachables. * Specific chapters on parenteral administrations devices, injection site pain assessment, and parenteral product specifications and stability testing. * Forward-thinking discussions on the future of parenteral product manufacturing, and siRNA delivery systems. * New chapters covering recent developments in the areas of visual inspection, quality by design (QbD), process analytical technology (PAT) and rapid microbiological methods (RMM ), and validation of drug product manufacturing process.

Persistence and Vigilance: A View of Ford Motor Company's Accounting Over Its First Fifty Years is an exploration of the financial leadership that guided the company through periods of phenomenal growth amidst the economic and political upheaval of the early 20th century. Since its inception in 1903, the Ford Motor Company has implemented traditional accounting methods, as well as innovative financial reporting and business policies, to navigate industry competition, two world wars, and labor issues such as the famous $5 day. While much has been written on the presumption of Henry Ford's indifference to the financial details of operating the company that bore his name, there remains much to be said for the talented individuals working behind the scenes to spearhead the day-to-day financial and operational policies of the company. This includes initial co-founder James Couzens, super salesman and accountant Norval Hawkins, loyal Frank Klingensmith, and turn-around specialist Ernest Breech, among others. It was through their skill, persistence, and acumen that accounting policies and procedures evolved within the Ford Motor Company alongside the welcomed support of Edsel Ford, who was widely respected in his vision for strong financial oversight and organizational structure. From archival information found in the Benson Ford Research Center, this book describes the accounting and financial reporting methods utilized by the company through its years of growth, wartime production, economic downturns, and eventual restructuring under the presidency of Henry Ford II. It is essential reading for anyone interested in the history of the Ford Motor Company, as well as those curious about the application of accounting within the fast-growing automotive industry in the early to mid-1900s.

Advances in Epidemiological Modeling and Control of Viruses covers recent and advanced research works in the field of epidemiological modeling, with special emphasis on new strategies to control the occurrence and reoccurrence of viruses. The models included in this book can be used to study the dynamics of different viruses, searching for control measures, and epidemic models under various effects and environments. This book covers different models and methods of modeling, including data-driven approaches. The authors and editors are experienced researchers, and each chapter has been designed to provide readers with leading-edge information on topics discussed.

Important and significant volume looking at the remarkable history of Rioja wine for the first time enriching knowledge and addressing debates on inventions of tradition, impacts of crisis for innovation and progress. Based on unpublished sources, the book traces the economic, social, cultural and political evolution of Rioja's wine over the following decades offering new insight into the social history of wine production, distribution and consumption. Written by leading academic. Wide appeal to those interested in wine studies, sociology, social history, tourism, events, hospitality and food studies.

'The School Food Revolution is an important book that deserves success.' Journal of Organic Systems 'A great new book that describes how 'the humble school meal' can be considered as 'a litmus test of... government's political commitment to sustainable development.' Peter Riggs, Director, Forum on Democracy & Trade 'The School Food Revolution should be an inspiration for policy makers and for school heads and school canteen operators.' Tom Vaclavik, President, Organic Retailers Association School food suddenly finds itself at the forefront of contemporary debates about healthy eating, social inclusion, ecological sustainability and local economic development. All around the world it is becoming clear - to experts, parents, educators, practitioners and policy-makers - that the school food service has the potential to deliver multiple dividends that would significantly advance the sustainable development agenda at global, national and local levels. Drawing on new empirical data collected in urban and rural areas of Europe, North America and Africa, this book offers a timely and original contribution to the school food debate by highlighting the potential of creative public procurement - the power of purchase. The book takes a critical look at the alleged benefits of school food reform, such as lower food miles, the creation of markets for local producers and new food education initiatives that empower consumers by nurturing their capacity to eat healthily. To assess the potential of these claims, the book compares a variety of sites involved in the school food revolution - from rural communities committed to the values of 'the local' to global cities such as London, New York and Rome that feed millions of ethnically diverse young people daily. The book also examines the UN's new school feeding programme - the Home Grown Programme - which sees nutritious food as an end in itself as well as a means to meeting the Millennium Development Goals. Overall, the book examines the theory, policy and practice of public food provisioning, offering a comparative perspective on the design and delivery of sustainable school food systems. The cover illustration is by a Roman child. The authors would like to thank the City of Rome (Department for School and Educational Policies) for permission to reproduce it.

Welcome to Bardstown, KY: The Bourbon Capital of the World (R) Bourbon's popularity is now a global phenomenon, but you need only look at Bardstown, Kentucky, to see its remarkable and evolving impacts. This historic city of 13,500 people is booming as a result, but it's also enduring growing pains. The economic impacts from a massive influx of tourists to what is now America's bourbon epicenter are positive on many levels, but with those crowds comes pressure on infrastructure, services and accommodations. The demand for hotels, bars and restaurants is at an all-time high, and investors from across the globe are addressing those needs. Still, as a two-century-old Kentucky cultural and entertainment center long before it was discovered by bourbon drinkers ;- many locals want to ensure the traditional Bardstown experience doesn't disappear amid novel entertainment options.

An ambitious and shocking expose of America's hidden empire in Liberia, run by the storied Firestone corporation, and its long shadow In the early 1920s, Americans owned 80 percent of the world's automobiles and consumed 75 percent of the world's rubber. But only one percent of the world's rubber grew under the U.S. flag, creating a bottleneck that hampered the nation's explosive economic expansion. To solve its conundrum, the Firestone Tire and Rubber Company turned to a tiny West African nation, Liberia, founded in 1847 as a free Black republic. Empire of Rubber tells a sweeping story of capitalism, racial exploitation, and environmental devastation, as Firestone transformed Liberia into America's rubber empire. Historian and filmmaker Gregg Mitman scoured remote archives to unearth a history of promises unfulfilled for the vast numbers of Liberians who toiled on rubber plantations built on taken land. Mitman reveals a history of racial segregation and medical experimentation that reflected Jim Crow America-on African soil. As Firestone reaped fortunes, wealth and power concentrated in the hands of a few elites, fostering widespread inequalities that fed unrest, rebellions and, eventually, civil war. A riveting narrative of ecology and disease, of commerce and science, and of racial politics and political maneuvering, Empire of Rubber uncovers the hidden story of a corporate empire whose tentacles reach into the present.

This impressive collection offers the first systematic global and comparative history of textile workers over the course of 350 years. This period covers the major changes in wool and cotton production, and the global picture from pre-industrial times through to the twentieth century. After an introduction, the first part of the book is divided into twenty national studies on textile production over the period 1650-2000. To make them useful tools for international comparisons, each national overview is based on a consistent framework that defines the topics and issues to be treated in each chapter. The countries described have been selected to included the major historic producers of woollen and cotton fabrics, and the diversity of global experience, and include not only European nations, but also Argentina, Brazil, China, Egypt, India, Japan, Mexico, Turkey, Uruguay and the USA. The second part of the book consists of ten comparative papers on topics including globalization and trade, organization of production, space, identity, workplace, institutions, production relations, gender, ethnicity and the textile firm. These are based on the national overviews and additional literature, and will help apply current interdisciplinary and cultural concerns to a subject traditionally viewed largely through a social and economic history lens. Whilst offering a unique reference source for anyone interested in the history of a particular country's textile industry, the true strength of this project lies in its capacity of international comparison. By providing global comparative studies of key textile industries and workers, both geographically and thematically, this book provides a comprehensive and contemporary analysis of a major element of the world's economy. This allows historians to challenge many of the received ideas about globalization, for instance, highlighting how global competition for lower production costs is by no means a uniquely modern issue, and has b

The U.S. laser industry is a major player in the country's economy, with its products used in factories, laboratories, offices, homes and motor vehicles around the country. The issues addressed by the laser industry during the past several decades - patent litigation, worker education, export controls, international standardization, and others - are those that any emerging high-tech industry will have to face. Offering a roadmap for future technology development and commercialization, this book chronicles the laser and electro-optics industry and its issues for business executives, scientists and technicians, attorneys, journalists, historians, and others.

The pharmaceutical and healthcare industry is hugely complex because it involves so many markets, products, processes and intermediaries. It is also heavily regulated, global, and used by everyone at some stage in their life. No wonder the supply chain for delivery of healthcare services is often fragmented and understood only in discrete sections. Changes in one area impact upon the others, and environmental factors such as pricing, regulatory change or actions by competitors impact the whole supply chain in ways that are not easily understood or managed. Accelerating technology, the commoditization of healthcare, increasing demands from ageing populations all influence the approach that suppliers of pharmaceutical products and services worldwide need to take if they are to design and manage an effective supply chain that will be capable of: exploiting their intellectual property in a sustainable way; providing safe and continuous provision of drugs or devices; and sustaining with resilience, yet still be flexible and cost efficient. Supply Chain in the Pharmaceutical Industry offers the basis for organizations to develop their own blueprint for managing the opportunities and threats to the pharmaceutical supply chain. Using examples from companies and markets across the world Rob Whewell offers a very vivid picture of the developing trends for pharmaceutical companies; the customers and markets they serve and points to some of the elements that underpin sustainable pharmaceutical strategies. The current global banking and financial crisis illustrates the important role played by regulation. The healthcare industry is similar in scope, and complexity, yet the implications of error are worse - life threatening. This review of key industry parameters will provide senior executives in the industry and policy makers in healthcare with a broad perspective of the issues and illustrates an understanding of the task at hand.

Wine and Spirits Book of the Year 2017

In little more than a century, the drive towards industrial and intensive farming has altered every aspect of the cheesemaking process, from the bodies of the animals that provide the milk to the science behind the microbial strains that ferment it. Reinventing the Wheel explores what has been lost as expressive, artisanal cheeses that convey a sense of place have given way to the juggernaut of homogeneous factory production.

While Bronwen and Francis Percival lament the decline of farmhouse cheese and reject the consequences of industrialisation, this book's message is one of optimism. Scientists have only recently begun to reveal the significance of the healthy microbial communities that contribute to the flavour and safety of cheese, while local producers are returning to the cheese-making methods of their parents and grandparents.

This smart, engaging book sheds light on the surprising truths and science behind the dairy industry. Discover how, one experiment at a time, these dynamic communities of researchers and cheesemakers are reinventing the wheel.

Cotton was the first industrialized global trade. This four-volume reset edition charts the rise of British trade in cotton from the days of small-scale trading between the Middle East and India to the domination of British-led industrialized manufacture.

Economic restructuring has been a notable feature of so-called mature industrial economies such as the UK and Australia in the last two decades, with deregulation, privatisation, technological change and globalisation combining to reshape such economies. Some industries have grown, while others have declined. Moreover, while overall employment in the UK and Australia has grown, many newly-created positions require skills not found in the industries shedding labour, or are in casualised and low paid occupations. Many lesser-skilled workers leaving declining industries are therefore at risk of long-term unemployment or leaving the workforce entirely. Both mental and physical health can be affected after redundancy. It is therefore crucial that the measures put in place in many domains of social policy (such as formal health policy, employment assistance, community development, housing assistance and so on) to adequately address the difficulties confronting this group. This volume takes a closer look at the impact of manufacturing - notably automotive - plant closures in the UK (Birmingham) and Australia (Adelaide) in recent years and policy responses to those closures. It attempts to tease out differences in policy response and effectiveness, and attempts to identify areas where policy could be made to work better in terms of adjusting to large scale manufacturing change and resulting job losses. In so doing, it begins, for the first time we believe, to take a comparative approach to understanding the impact of plant closures and policy responses.

This book was published as a special issue of Policy Studies.

Ai Hisano exposes how corporations, the American government, and consumers shaped the colors of what we eat and even the colors of what we consider "natural," "fresh," and "wholesome." The yellow of margarine, the red of meat, the bright orange of "natural" oranges-we live in the modern world of the senses created by business. Ai Hisano reveals how the food industry capitalized on color, and how the creation of a new visual vocabulary has shaped what we think of the food we eat. Constructing standards for the colors of food and the meanings we associate with them-wholesome, fresh, uniform-has been a business practice since the late nineteenth century, though one invisible to consumers. Under the growing influences of corporate profit and consumer expectations, firms have sought to control our sensory experiences ever since. Visualizing Taste explores how our perceptions of what food should look like have changed over the course of more than a century. By examining the development of color-controlling technology, government regulation, and consumer expectations, Hisano demonstrates that scientists, farmers, food processors, dye manufacturers, government officials, and intermediate suppliers have created a version of "natural" that is, in fact, highly engineered. Retailers and marketers have used scientific data about color to stimulate and influence consumers'-and especially female consumers'-sensory desires, triggering our appetites and cravings. Grasping this pivotal transformation in how we see, and how we consume, is critical to understanding the business of food.

Food and agribusiness is one of the fastest changing global markets; change that is driven by technology, developments in manufacturing and supply, and a growing consumer engagement. The success of the agri-food industry and many of our household brand names will depend on how much you understand about these changes and the extent to which you can deliver secure and competitive products in the face of growing expectations about food safety and quality, as well as changing attitudes about the environment, human diet and nutrition, and animal welfare. The Crisis of Food Brands offers perspectives on many key aspects of these changes including the role of business, policy-makers, and the media in communicating with and engaging stakeholders about: o relevant and dynamic models of risk and crisis management; o the value of innovative and, sometimes controversial, food systems; o their buying behaviour and attitudes to movements such as organic and fair trade; o how and where we source and buy our food now (and in the future). The quality of the original research that underpins this book and the imagination and practicality with which the authors address its applications for the industry is first rate. Anyone with responsibility for marketing food, communicating about the food industry, or engaging with consumers will find this an important source of ideas and inspiration.

Dramatically restructured, more than double in size, the second edition of the Food Properties Handbook has been expanded from seven to 24 chapters. In the more than ten years since the publication of the internationally acclaimed and bestselling first edition, many changes have taken place in the approaches used to solve problems in food preservation, processing, storage, marketing, consumption, and even after consumption. Incorporating changes too numerous to list, this updated edition provides new measurement techniques, basic data compiled for diversified food groups, worked-out examples, and detailed graphs and illustrations. Explores Empirical and Theoretical Prediction Models The book clearly defines the terminology and elucidates the theory behind the measurement techniques, including applications and limitations of each method. It includes data on sources of error in measurement techniques and experimental data from the literature in graphical or tabular form. The volume also elucidates empirical and theoretical prediction models for different foods with processing conditions, descriptions of the applications of the properties, and coverage of where and how to use the data and models in food processing. User-Friendly Format Puts the Latest Information within Easy Reach Still under the aegis of Shafir Rahman, the new edition is now an edited volume, benefitting from the input and expertise of numerous contributors spanning both the globe and the many disciplines that influence the field. Presented in a user-friendly format, the second edition remains the definitive, and arguably the only, source for data on physical, thermal, thermodynamic, structural, and acoustic properties of foods.

Food is an extraordinary expression of culture; the assortment of flavours, smells, colours and appearance match the diversity of the cultures from which they come and provide very visible evidence of the migration of populations and of the growing multiculturalism of many countries. Adam Lindgreen and Martin K. Hingley draw on research into European, Latin American and (Near and Far) Eastern markets to provide a comprehensive collection of original, cutting-edge research on the opportunities that the changing landscapes of ethnic, religious and cultural populations present for businesses and marketers. The New Cultures of Food uses the perspective of food culture to explore the role of food as a social agent and attitudes to new foodstuffs amongst indigenous populations and to indigenous food amongst immigrant communities. Opportunities and routes to market for exploiting growing demand for ethnic food are also investigated. This is an important book for food and consumer businesses, policy makers and researchers seeking to understand changing global markets and the significance of food as an indicator of social and religious attitude, diet and ethnic identity.

Much of the fascination which Soviet aircraft and its associated aerospace industry holds for the analyst, enthusiast or ordinary member of the public, stems from the thick fog of secrecy that enveloped the industry throughout the 'Cold War' until the collapse of the Soviet Union in 1990/91. Until then details which in case of Western designs could be found from the nearest reference book was in the case of Russian aircraft often a matter of conjecture and an inaccurate article written by a western journalist. This author has been fortunate to have obtained much original and previously unpublished information from the former Soviet Union for this unique volume on the history of the Soviet Aircraft Industry Since 1909. It gives the reader a clear understanding of the unique characteristics of Soviet-designed aircraft, in particular military types that at times caused great concern in the West with regards to the technical advances inherent in their design. The book is as much a history of the USSR as it is its, aerospace industry, culminating as it does with President Putin's Russian Federation.

This updated "Second Edition "details how marketers, forecasters, and brand planners can achieve optimal success by building internally consistent simulation models to project future behavior of patients, physicians, and R&D processes. By introducing the reader to the complexities facing many pharmaceutical firms, specifically issues around cross-functional coordination and knowledge integration, this guide provides a framework for dynamic modeling of interest to several pharmaceutical markets, including epidemiology, market definitions, compliance/persistency, and revenue generation in the context of patient flows or movements.

Features in the text include:

An exploration of the Totonac native community of Papantla, Veracruz, during the last half of the eighteenth century. Told through the lens of violent revolt, this is the first book-length study devoted to Papantla during the colonial era. The book tells the story of a native community confronting significant disruption of its agricultural tradition, and the violence that change provoked. Papantlas story is told in the form of an investigation into the political, social, and ethnic experience of an agrarian community. The Bourbon monopolisation of tobacco in 1764 disturbed a fragile balance, and pushed long-term native frustrations to the point of violence. Through the stories of four uprisings, Jake Frederick examines the Totonacs increasingly difficult economic environment, their view of justice, and their political tactics. Riot! argues that for the native community of Papantla, the nature of colonial rule was, even in the waning decades of the colonial era, a process of negotiation rather than subjugation. The second half of the eighteenth century saw an increase in collective violence across the Spanish American colonies as communities reacted to the strains imposed by the various Bourbon reforms. Riot! provides a much needed exploration of what the colony-wide policy reforms of Bourbon Spain meant on the ground in rural communities in New Spain. The narrative of each uprising draws the reader into the crisis as it unfolds, providing an entree into an analysis of the event. The focus on the community provides a new understanding of the demographics of this rural community, including an account of the as yet unexamined black population of Papantla.

In this study, Emily Byrne Curtis explores as her subject lenses, spectacles, aventurine glass, and windows found in China from the sixteenth century. She traces their technological development back to the glassworks in Murano, Venice, and explores their significance in terms of Venice's commerce with China. Because glassware also figured among the gifts which three papal legates from the Vatican presented to the Kangxi and Yongzheng emperors, the author examines many documents from the archives in Rome and the Vatican; the study therefore touches, to an extent, on the history of the Catholic Church in China. Curtis also discusses in the volume some contemporary Chinese references and verses to European glassware, and in the case of enamel materials, she discloses the pronounced effect their use had upon the decor of Chinese porcelains.

This Second Edition examines the mechanisms and means to establish regulatory compliance for pharmaceutical products and company practices. It focuses on major legislative revisions that impact requirements for drug safety reviews, product regulatory approvals, and marketing practices. Written by top industry professionals, practicing attorneys, and FDA regulators, it includes policies and procedures that pharmaceutical companies need to implement regulatory compliance post-approval.

New chapters cover:

• the marketing of unapproved new drugs and FDA efforts to keep them in regulatory compliance
• pharmacovigilance programs designed to prevent widespread safety issues
• legal issues surrounding the sourcing of foreign APIs
• the issues of counterfeit drugs
• updates on quality standards

Written by an experienced business lawyer in the technology, scientific and engineering community, this publication is for the engineer with an innovative high-tech idea or concept who needs those crucial business insights and strategies to move that idea forward. It offers key analysis on how to leave a current employer, gain access to technologies and potential talent, and considers other issues that can reduce problems down the road. It even includes a step-by-step guide for accessing and protecting intellectual property at the earliest stages. To assist in the fundraising process, this resource explores all the available options to capitalize a business - from self-funding, to bootstrapping, to angel investors, to venture capital to government grants, to bank loans, to joint ventures. It also looks at the best ways to form a company so as to take advantage of various tax and business strategies, discusses compensation of employees with stock options or restricted stock plans, explains how an emerging company can expand internationally, and covers some key exit strategies such as an IPO or a merger/acquisition. It covers most everything a new technology business will face including hiring, firing, contracts, leases, loans, and product warranties. As you read, you will find this book is full of the stuff that engineers love: statistics, data, tools, spreadsheets, and research. But it also full of the anecdotal evidence and practical advice needed to stay the course. Now is a tremendous time for entrepreneurship. Although there have been periodic slowdowns in the economy, if you believe in a future, high-tech is the future in which to believe. This book is part of the Taylor & Francis/CRC Press series "What Every Engineer Should Know About... . Like the other books in the series, it is designed to provide you with important knowledge that will help you along your career path. This one will also help you make that path your own.

This book focuses on the development and trends of Chinese local luxury industry in the digital era, which brings a new round of manufacturing transformation and upgrading, as well as development opportunities. It reveals the connotation and mechanism of the new local luxury brands in China step by step by answering the questions of "what, why and how". Through the analysis of 200 + questionnaires by SPSS statistical tools and case study, the book concludes the internal mechanism and theoretical support for China to cultivate new local luxury brands. It presents an overview on the current China's local luxury industry.