Each year hundreds of new drugs are approved for the marketplace. The approval of a single new drug is the result of years of screening tens of thousands of compounds, performing pre-clinical research on their effects, and designing, implementing, and analyzing the results of clinical trials. This book provides a general guide to statistical methods used in the pharmaceutical industry, and is aimed at graduate students and researchers who want to know more about statistical applications in all phases of the drug development process. The 19 chapters authored by over 30 statisticians working in the industry follow the general sequence of drug development, from pre-clinical research and saftey assessment to dose finding, safety studies, large clinical trials, analysis of health economic data, and fianlly manufacturing and production. Special topics such as single patient analysis and the impact of patient compliance show the broad spectrum of applications of data analysis methods. Each chapter illustrates a practical problem using data from actual studies by describing the study, the data, the methods, and the results. All of the analyses are done with S-PLUS, and the data and code are provided both in appendices to the chapters and on the companion Springer-Verlag web site, making it possible to reproduce the results and extend the analyses. Prior knowledge of the software is not required to follow the analyses. Steven P. Millard is a statistical consultant and also Manager of Consulting Services for MathSoft, Inc. (Data Analysis Products Division.) He has applied statistical methods to projects ranging from quality control in bioassay to measuring water quality to automating home appraisal, and has taught courses in S-PLUS for over 10 years. He is the author of the book Environmental Statistics with S-PLUS (CRC Press) as well as the S-PLUS add-in module ENVIRONMENTALSTATS for S-PLUS. Andreas Krause is a statistical consultant in the pharmaceutical industry and works for Novartis Pharma AG. He has extensive experience in graphical and numerical data analysis as well as programming, has taught numerous classes with and on S-PLUS, and is an S_PLUS user from the early days on. He is also author of the book The Basics of S and S-PLUS (Springer).

This book focuses on the implications of digitalisation in the mobility service industry. Based on an analysis of more than 450 survey responses, it explores and assesses mobility in the age of digitalisation. The content covers both changes in the relationship between the company and its customers and a potential paradigm shift among leading companies. The findings suggest that a shift from traditional mobility management to a more customer-centred management perspective is both widely accepted and increasingly necessary. Nevertheless, the inclusion of services that are not primarily concerned with overcoming spatial distances is considered to be less attractive. Given its scope, the book will be of interest to researchers and professionals who are involved in digitalisation in the mobility service industry.

The current restructuring of the world-economy under global capitalism has further integrated international trade and production. It thus has brought to the fore the key role of commodity chains in the relationships of capital, labor, and states. Commodity chains are most simply defined as the link between successive processes of manufacturing that result in a final product available for individual consumption. Each production site in the chain involves organizing the acquisition of necessary raw materials plus semifinished inputs, the recruitment of labor power and its provisioning, arranging transportation to the next site, and the construction of modes of distribution (via markets and transfers) and consumption. The contributors to this volume explore and elaborate the global commodity chains (GCCs) approach, which reformulates the basic conceptual categories for analyzing varied patterns of global organization and change. The GCC framework allows the authors to pose questions about development issues, past and present, that are not easily handled by previous paradigms and to more adequately forge the macro-micro links between processes that are generally assumed to be discretely contained within global, national, and local units of analysis. The paradigm that GCCs embody is a network-centered, historical approach that probes above and below the level of the nation-state to better analyze structure and change in the contemporary world.

Bioactive peptides have been receiving attention recently due to their applications as health-promoting agents. Derived from food proteins and other natural sources, they exhibit various beneficial effects such as preventing diseases or modulating physiological systems once absorbed. As the market for nutraceuticals and functional foods continues to expand, consumer interest has also grown and there are many common foods that have shown an abundance of bioactive peptides, including dairy products, cereal, legumes, meat, and numerous other sources. In this newest addition to the series Nutraceuticals: Basic Research and Clinical Applications, Bioactive Peptides: Production, Bioavailability, Health Potential, and Regulatory Issues provides a comprehensive review of the current state of knowledge in the field of food protein hydrolysates and bioactive peptides, their food sources, bioavailability, production, applications, functionalities, health potentials, and regulatory issues governing their use. Features Discusses different methodologies employed for scaling up bioactive peptides commercially Provides information on optimizing the production process Explains various bioactive properties exerted by different types of bioactive peptides Explores the application of metabolomics to the study of bioactive peptides With over 20 chapters written by established subject matter experts in their field, this book provides timely information and discusses the latest developments of bioactive peptides. It will be useful for researchers, academics, and industry experts, and can serve as an excellent resource for anyone interested in enhancing their knowledge in the field of bioactive peptides.

General Motors, the largest corporation on earth today, has been the owner since 1929 of Adam Opel AG, Russelsheim, the maker of Opel cars. Ford Motor Company in 1931 built the Ford Werke factory in Cologne, now the headquarters of European Ford. In this book, historians tell the astonishing story of what happened at Opel and Ford Werke under the Third Reich, and of the aftermath today. Long before the Second World War, key American executives at Ford and General Motors were eager to do business with Nazi Germany. Ford Werke and Opel became indispensable suppliers to the German armed forces, together providing most of the trucks that later motorized the Nazi attempt to conquer Europe. After the outbreak of war in 1939, Opel converted its largest factory to warplane parts production, and both companies set up extensive maintenance and repair networks to help keep the war machine on wheels. During the war, the Nazi Reich used millions of POWs, civilians from German-occupied countries, and concentration camp prisoners as forced laborers in the German homefront economy. Starting in 1940, Ford Werke and Opel also made use of thousands of forced laborers. POWs and civilian detainees, deported to Germany by the Nazi authorities, were kept at private camps owned and managed by the companies. In the longest section of the book, ten people who were forced to work at Ford Werke recall their experiences in oral testimonies. For more than fifty years, legal and political obstacles frustrated efforts to gain compensation for Nazi-era forced labor; in the most recent case, a $12 billion lawsuit was filed against the computer giant I.B.M. by a group of Gypsy organizations. In 1998, former forced laborers filed dozens of class action lawsuits against German corporations in U.S. courts. The concluding chapter reviews the subsequent, immensely complex negotiations towards a settlement - which involved Germany, the United States, Poland, Russia, Ukraine, Belarus, Czech Republic, Israel and several other countries, as well as dozens of well-known German corporations.

Biojet fuels have the potential to make an important contribution towards decarbonising the aviation sector. Biojet Fuel in Aviation Applications: Production, Usage and Impact of Biofuels covers all aspects of this sustainable aviation fuel including aviation biofuel public policies, production technologies, physico-chemical properties, combustion performances, techno-economics of sustainable fuel production, sustainability and energywater-food (EWF) nexus. This must-have book also charts the current state of the industry by discussing the relevant industry players who are currently producing alternative aviation fuels and flight tests, while also providing a glimpse of the future of the industry. This comprehensive book is written for undergraduate students, postgraduate students, researchers, engineers and policy makers wanting to build up knowledge in the specific area of biojet fuel or the broader fields of sustainable energy and aeronautics.

Preston was no ordinary town during the nineteenth century. While king cotton reigned supreme throughout Lancashire, the underlying ills associated with this industry were very often highlighted particularly starkly there. Child labour, shocking working conditions with appallingly long hours and pitifully low wages, as well as the constant risk of suffering horrific accidents in the cotton mills, all fostered a deep sense of hostility among the operatives towards the employers. Overcrowded and insanitary housing, disease, poverty and awful wretchedness were often to be witnessed in the fast-growing working-class districts of Preston.Against this backdrop the nascent trade unions and political and social reformers began to challenge the unbridled mastery of the millowners. Trade disputes, confrontations, lockouts, strikes and tragic episodes of violence were the inevitable consequence of this lethal mix of hardship and employer intransigence, and dominated affairs in the town for many years. This book by local author J.S. Leigh is a powerful indictment of the industrial system that caused such suffering to Preston's cotton 'martyrs'.

The book is essential for food manufacturers using HACCP procedures to ensure quality control. In particular, it offers practical informatio n for production engineers and quality assurance personnel involved in minimizing the risk of foreign body contamination reaching the consum er. Recent developments in both technology and techniques are assessed and compared to more established methods in order to provide the most up-to-date and pragmatic advice for food manufacturers.The major sour ces of foreign body contamination are shown and the methods and machin ery available to prevent food adulteration are analyzed. The capabilit ies and limitations of the machines used to remove foreign matter from food are considered in detail. It describes the detection methods ava ilable and how they are used in the food industry. In particular the c apabilities and limitations of the machines used is dealt with in suff icient detail for them to be understood by technologists and scientist s from disciplines other than engineering.

The economics of regional clusters, where business formation, technological innovation, and the emergence of a highly-skilled labor force converge, has become a popular topic. This fascinating book applies a variety of tools and models to analyze, in depth, the formation and growth of high-tech clusters. It does this first by exploring the institutional forces that promote the failure or success of such agglomerations, and then by focusing on the dynamics of the labor force.

Compaction of powder constituents-both active ingredient and excipients-is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application. This unique reference covers: The physical structure of pharmaceutical compacts Bonding phenomena that occur during powder compaction Compression mechanisms of pharmaceutical particles Theories and basic principles of powder compaction New topics include: Compaction data analysis techniques The migration of powder constituents into commercial manufacture Instrumentation for compaction Compaction functionality testing, which is likely to become a USP requirement Design space for compaction Metrics required for scalability in tablet compression Interactive compaction and preformulation database for commonly used excipients

The 1970s and 1980s witnessed growing concern in the United States regarding the relative decline of the American economy and, for defense planners, the military's growing dependence on foreign production of weapons' parts and subcomponents--the guts of many critical weapons systems. The period also witnessed growing interest in industrial policy as a tool for promoting U.S. international competitiveness, defense sectors proving to be particularly attractive candidates for government economic intervention. This study traces the evolution of defense dependence and the U.S. government's response to this dilemma by examining policy ideas and experiments in four defense industries--machine tools, semiconductor manufacturing, ball bearings, and high-definition television technologies--explaining successes and failures, and reviewing prospects for expansion.

In 1962, Masahiro Shima founded Shima Seiki, with the aim of developing a fully automated seamless glove-knitting machine. Following this success, the company expanded into flat knitting machines. However, the age of the computer brought a whole new era for Shima Seiki. By committing to computerization in its mainstream products, Shima Seiki gradually began to stand apart from its competitors. Shima Seiki's focus on computer-aided knit design and programming, in fact led to a revolution in the fashion industry. Written by the inventor himself, this book looks at how Masahiro Shima developed both the technology and philosophy to enable his company to be market leaders in industrial knitting machines - and fundamentally change the fashion industry. This culminated in the launch of the company's Wholegarment knitting machine in 1995, which altered forever the way knitted garments are produced, and which today is used by fashion manufacturers across the world.

This book provides a clear analysis of the multi-level impacts of the existing international law regime related to genetic resources on developing countries. It does so through a cogent exposition of the different areas of the law pertaining to genetic resources that are relevant and impact on people's rights and livelihoods. Its focus on equity is a welcome addition to the literature.' - Philippe Cullet, University of London, UK'Camena Guneratne's thought-provoking book critically evaluates the clash between the private property approach to genetic resources embedded in international intellectual property conventions, and the competing values embedded in a variety of other conventions and laws. She contests key assumptions behind intellectual property regimes supporting genetic commerce, distinguishing the genetic 'commons' from other types of resource. This book provides a comprehensive scholarly dealing with the topics noted in its title, but also should increase debate about policy failures in responding to the risks to the underprivileged of the instruments we use to pursue our economic interests of the majority.' - Paul Martin, University of New England, Australia 'This is a wonderful book. All to often in the quest to preserve biodiviersity, we forget that the equation of equity hs to be the forefront of the debates on sustainable development. Dr. Guneratne rectifies this mistake.This linkage between biodiversity, politics and international law is of such a high calibre, that it is likely that this work will become a key text for students and scholars alike.' - Alexander Gillespie, University of Waikato, New Zealand This book examines current developments in international law which regulate the uses of plant genetic resources for food and agriculture, and the various property regimes which are applied to these resources by these international agreements. In the current context of the global food crisis, the development and stability of national agricultural systems is an urgent concern, particularly among developing countries. This stability, and national food security, will potentially be threatened if these countries are unable to have free access to agricultural crop plants. This book analyses a range of international agreements including the recently adopted Nagoya Protocol and demonstrates that in their current implementation they favor private ownership of these resources rather than free access. The book takes the position that this is inherently inequitable and these resources should be maintained in the public domain. This book will be of use to a wide range of readers from students and scholars to those working in the fields of trade and intellectual property, human rights, environmental conservation and advocacy on international issues. It contains a rigorous legal analysis of current international law development on the issue based on the negotiations which have taken place in the relevant forums, and will therefore be particularly useful to lawyers and legal scholars. It is also written in an uncomplicated style which makes it readily accessible to non-lawyers and the case studies and empirical data used throughout the book adds to its interest.

In the 1970s, as car enthusiasts in the U.S. grew bored with models manufactured under tightening pollution and safety regulations, some innovative dealers exploited a legal loophole-designed to allow U.S. soldiers and diplomats to return from abroad with their vehicles-to import exotic cars never intended for sale in America. During the 1980s, a rise in the value of the dollar made car shopping in Europe a bargain hunter's dream. A network of unauthorized "gray market" dealers emerged, bypassing factory channels. Middle-class Americans suddenly found they could afford a Mercedes or BMW. These cars had to pass through U.S. customs, equipped to handle only a few independent imports annually. As applications ballooned, the regulatory system collapsed. This is the story of a misunderstood but fascinating period in the automotive industry, when creative importers found ways to put American motorists in new Ferraris while the EPA and DOT were backed up with mounds of paperwork.

A Mechanistic Approach to Medicines for Tuberculosis Nanotherapy examines drug carrier development for controlled, targeted, pH and stimuli responsive drug releases for tuberculosis. The book provides in-depth information about mycobacterium tuberculosis, tuberculosis formation, and synthetic procedures for carrier synthesis, characterizations and mechanistic approaches. Key topics include the properties and functions of nanomedicines and how they might be applied for clinical diagnosis and treatment. Emphasis is placed on the basic fundamentals, biomaterial formulations, design principles, fabrication techniques, and transitioning bench-to-bed clinical applications. This book is useful for new researchers who focus on nanomedicine, stem cell therapy and bone tissue engineering. In addition, it introduces experienced researchers and clinicians to key trends, thus increasing their knowledge in drug discovery for tuberculosis and nanomedicine.

The story of the company that was founded by the inventor of the snowmobile

In 1942, Joseph-Armand Bombardier invented the snowmobile and founded his company to manufacture them. From its humble beginnings as an entrepreneurial company in rural Quebec, led by an enterprising inventor, Bombardier Inc. has emerged as a global leader in the transportation industry. This book tells the fascinating tale of this remarkably well managed company that has enjoyed spectacular growth in its chosen markets through strong leadership and management strategy, succession planning, strategic diversification, and turnaround and acquisition artistry.The fascinating story of the world's largest rail manufacturer for both railway and subwayReveals why Bombardier Inc. is a multi-faceted global company yet nobody knows their name Written by Larry MacDonald the author of Nortel Network

"The Bombardier Story" shows how invention and entrepreneurship, management and leadership, smooth succession planning, and turnaround and acquisition built this global powerhouse.

Textiles and computing have long been associated. High volume and low profit margins of textile products have driven the industry to invest in high technology, particularly in the area of data interpretation and analysis. Thus, it is virtually inevitable that soft computing has found a home in the textile industry. Contained in this volume are six chapters discussing various aspects of soft computing in the field of textiles and apparel.

Pharmacy Practice Research Case Studies provides examples and details regarding how pharmacy practice research has transformed over the past decade and how this is impacting overall health. This book presents several methodologies and techniques used in current pharmacy practice. According to the United Nations Sustainable Development Goals, countries around the world are aiming to achieve Universal Health Coverage. In this context, pharmacists are a vital part of the healthcare teams and the book portrays the research methods used in conducting pharmacy practice and medicines use research. The professional role of pharmacists has evolved tremendously over the past few decades across the globe and the pace of change has been interestingly phenomenal in varying aspects. The book provides a great resource for pharmacists, pharmaceutical scientists, policymakers, and researchers to understand the dimensions of practice, education, research, and policy concerning pharmacy, and it provides the synthesis of the development so far, pointing to the needs and demands of the future.

Harrison analyzes how the U.S. research pharmaceutical industry, faced with domestic political opposition to the prices it charged for prescription drugs, chose to pursue its policy goal of greater appropriability of its intellectual property through the institutions of foreign economic policymaking. As Harrison explains, a new body of literature has developed to analyze the emergence of intellectual property as a major international trade issue. For many researchers, the inclusion of trade related intellectual property (TRIPS) into the Uruguay round of the General Agreement on Tariffs and trade (GATT) negotiations marks an important demonstration of the political influence of U.S. knowledge-intensive industries. However, as he demonstrates, a more thorough specification of the domestic political environment reveals that the research pharmaceutical industry was incapable of achieving its domestic policy objectives at the same time that it is credited with immense international political power. By providing a theory of institutional choice, Harrison reconciles this incongruity. He explains the strategic choices of the research pharmaceutical industry as a function of the transaction costs associated with pursuing its policy objectives within a variety of institutional alternatives. He concludes that he internationalization of intellectual property rights was a result of the changing domestic political environment in which the research pharmaceutical industry found itself the loser in a series of domestic economic policy battles. A thoughtful analysis of particular important to scholars, researchers, and policy makers involved with international trade, intellectual property, the pharmaceutical industry, and public policy.

Paper and the British Empire examines the evolution of the paper industry within British organisational frameworks and highlights the role of the Empire as a market and business-making area in a world of shrinking commerce and rising trade barriers. Drawing on a valuable range of primary sources, this book covers the period 1861-1960 and examines events from the establishment of free trade backed by the gold standard to Britain's membership of the European Free Trade Association. In the field of the paper industry, the speed and intensity of the industrialisation process around the globe have been shaped by a wide variety of variables, including the surrounding institutional framework; entrepreneurial and organisational strategies; the cost and accessibility of transport; and the availability of capital, knowledge, energy resources, and technology. The supply of papermaking raw materials has also been key and has historically been the most important determinant for geographical location and dominance. The research in this work focuses on the roles played by such variants, on the one hand, and demand characteristics on the other. In particular, it considers developments connected to a quest for Empire-grown raw materials in order to tackle the problem of the lack of indigenous raw materials and the resulting dependence on Scandinavian wood pulp imports. This text is of considerable interest to advanced students and researchers in economic history, business history, and the paper industry, and will also be useful to organisations working within the pulp and paper industries.

This book proposes that, within the automotive industry, revised marketing principles and innovative marketing strategies are needed to address more effectively the unprecedented challenges posed by the modern digital revolution. The starting point for these proposals is a thorough analysis of the evolution of marketing in the industry across three ages of technological innovations - the mechanical, the electronic, and the digital. The main objectives are first, to illustrate how study of the past can help carmakers as they move forward into the unknown, and second, to identify the main choices that they will face. The central premise is that unusual times call for unusual strategies. By mining the past in order to foresee likely future developments regarding competition and marketing strategies within the car industry, the book will appeal both to researchers and to present or future managers in the automotive and other innovation-driven sectors.

Henry Bernard Loewendahl scrutinizes the relationship between multinational companies, regional development, and governments, using a framework of bargaining between government and multinationals. He critically analyzes the role of foreign investment in economic development, and examines how governments can link inward investment to regional economic development. Based on extensive use of data, interviews and case studies of Siemens and Nissan's UK investment, the book shows why MNCs have invested in the UK in the past, how they bargained with the government, and what the impact was on the national and regional economies. In particular, through linking the strategy of multinationals to the location advantages of the UK, it is argued that labor flexibility and incentives were crucial to investment decisions. Loewendahl recommends a framework to integrate endogenous and exogenous approaches to developments; and proposes a greater role for the region and the EU to control incentives and monitor multinationals.

Food Waste Recovery: Processing Technologies, Industrial Techniques, and Applications, Second Edition provides information on safe and economical strategies for the recapture of value compounds from food wastes while also exploring their re-utilization in fortifying foods and as ingredients in commercial products. Sections discuss the exploration of management options, different sources, the Universal Recovery Strategy, conventional and emerging technologies, and commercialization issues that target applications of recovered compounds in the food and cosmetics industries. This book is a valuable resource for food scientists, technologists, engineers, chemists, product developers, researchers, academics and professionals working in the food industry.