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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
Ever since the International Human Genome Project achieved its
extraordinary goal of sequencing and mapping the entire human
genome, represented by approximately 3 billion base pairs, with its
far-reaching implications for understanding the causes of human
genetic disorders and their diagnosis, progress in the field has
not slowed down. In the fifth edition of the bestselling Color
Atlas of Genetics, readers will be rewarded with a complete and
current overview of the field, with an emphasis on the interface
between fundamental principles and practical applications in
medicine and the role of signaling pathways in causing diseases.
Using the acclaimed Flexibook format designed for easy visual
learning and retention, the atlas is invaluable for students,
clinicians, and scientists interested in staying up to date in this
fast-evolving area. New fully illustrated topics in the revised
fifth edition of the atlas include: An overview of disorders
resulting from structural changes of the genome (genomic disorders)
Abnormal imprinting patterns Examples of impaired signal pathways
(laminopathies, fibrillinopathies, cohesinopathies, and others) The
CRISPR-Cas system Genetic features of the aging processes Disorders
due to rearrangements of chromatin in the cell nucleus, and others
With almost 200 stunning color plates explained by concise texts on
the opposite pages, including tables presenting useful data, a
glossary of terms, key references, and online resources, the atlas
presents clear and accessible concepts. It is an excellent
refresher for investigators in any field of medicine or biology.
Every species has to preserve the integrity of its genome to ensure
faithful passage of genetic information to the progeny. At the same
time, there are times during the life of the organism and
population in general when a fine balance in genome stability and
diversification has to be made to benefit the survival of the
species. Genome Stability teaches the reader how various species
maintain this fine balance in genome stability and genome
diversification in response to their environments. Genome Stability
covers a wide range of topics, including the genome stability of
DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower
multicellular eukaryotes and mammals. Topics also include major DNA
repair mechanisms, the role of chromatin in genome stability, human
diseases associated with genome instability as well as changes in
genome stability in response to aging. Finally, Genome Stability
covers how epigenetic factors contribute to genome stability and
how the species pass the memory of the encounters to the progeny,
thus influencing the genome of the progeny in an indirect manner.
This volume is an essential resource for geneticists,
epigeneticists, and molecular biologists who are looking to gain a
deeper understanding of this rapidly-expanding field, and can also
be of great use to advanced students who are looking to gain
additional expertise in genome stability.
Based on their extensive experience of clinical work, the authors
emphasize the practical issues related to the healthcare of
individuals and families. Genetics for the Health Sciences takes an
holistic approach, from preconception to adulthood, and addresses
the false notion that clinical genetics is of relevance only to
those who are planning a family. The book enables nurses, midwives,
genetic counselors and doctors to apply the general principles of
genetics in their routine clinical practice. As well as discussing
the basic principles, Genetics for the Health Sciences also
describes the latest technologies and shows how these can be
applied to clinical practice. This is an essential text which helps
all those in clinical healthcare understand the genetics they need
in their professional roles. It is also an ideal coursebook for
students in the healthcare professions seeking an understanding of
core genetic principles and how these are applied in practice.
Reviews: 'The text is a compact, concise presentation of the basic
concepts in genetics science and the impact of genetics across the
lifespan. The organization of the text increases its usefulness to
clinicians as each specialty area could easily locate the
information most pertinent to their work...The text is well
illustrated throughout, again providing summarized information that
is easily accessed. An especially helpful feature of this text is
the presence of multiple case studies in each chapter, making this
text particularly useful for teaching. I think faculty teaching
students in advanced practice nursing programs and allied health
courses would find this text a succinct addition to their course.
However, I could also see this text being useful in RN preparation
curriculum. It could easily be a text that would carry over for
several specialty areas and provide additional material specific to
genetics in each area. Genetics for Health Sciences: A Handbook for
Clinical Healthcare is a welcome addition to the rather sparse
choices available for presenting genetics content in clinical
practice curriculum. Rebekah Hamilton, ISONG, June 2010 'Tremendous
progress in recent years has shaped the field of medical genetics,
which continues to expand to involve almost every aspect of human
health. Hence, it is necessary for every healthcare professional to
acquire a basic understanding of this science. This is clearly the
objective of this well-edited and structured book by Skirton and
Patch in its second updated edition. The authors' considerable
experience in genetics, through direct clinical practice in
addition to organisational and academic roles, can be appreciated
in the practical aspect of their writing. The book starts with
useful definitions and alerts the reader to the wide applicability
of genetics through clinical cases, raising questions that are
answered and discussed when relevant in later chapters. Important
aspects of genetic counselling, from basic skills such as risk
estimation using family trees to more complex ones related to
effective ethical communication with the clients in the light of
their needs and the different models of counselling, are then
discussed in two chapters. However, given their intrinsic function
in medical genetics, these issues are also efficiently tackled in
the clinical cases outlined in each chapter. The authors then
describe important scientific concepts and techniques that are
necessary for a good clinical understanding of genetics. Although
this section may seem short, the additional resources provided at
the end are very useful. Likewise, for all topics covered in the
book, the updated links provided serve as a handy catalogue for the
health professional seeking extra information. Next, the concepts
and techniques described in the first part of the book are applied
directly to common genetic conditions and issues faced by different
age groups, from prenatal care to older adulthood in separate
chapters. This organisation puts into perspective the importance of
genetics in different medical specialities and settings. This book,
with its concise yet comprehensive explanation of a complex rapidly
growing field, should prove to be a valuable resource for a diverse
audience of health professionals, including midwives, nurses and
physicians, who confront genetic issues during their daily practice
without being specialists in medical genetics.' Nadine Taleb,
Journal of Medical Genetics 'When first asked to write this book
review I thought to myself how it would be important to give a
rounded report on both the book's strengths and weaknesses. After
reading the book, however, I realised that it is difficult to find
weaknesses. The authors, Heather Skirton and Christine Patch,
between them have over 30 years of experience in clinical genetics.
Their experience of explaining genetics in their professional roles
shines through in the way they have written the book. They make
complex genetic principles interesting and understandable. The book
does not baffle or patronise. The book is easily navigated. It is
broken down into clear chapters that are ordered in a pleasingly
logical way. The first chapter 'sets the scene' by introducing the
reader to important concepts related to genetic health care
including issues such as ethical practice, the different forms of
genetic testing and the impact of genetic conditions on families.
The next chapters then discuss the family tree, counselling issues,
genetic science and public health genetics. The remaining chapters
then explore the core topics relating to particular life stages
from preconception to older adulthood. It engages the reader from
the start when it introduces seven 'core' families that reappear
throughout the book to highlight a number of key issues. The text
is peppered with clear illustrations, useful step by step guides,
practical checklists, and test yourself sections making the book
lively and dynamic. The test yourself sections make the book
student friendly and would also make good teaching aids to
lecturers and tutors. At the start of the book there is a list of
helpful websites and at the end of each chapter there is a list of
resources for those who wish to extend their knowledge. One of the
main strengths of this book is its refreshingly practical approach.
All too often books can be written in a way in which it is
difficult for the reader to transfer the knowledge that they have
gained into their day-to-day practice. The introduction states that
'the aim of this book is to enable those in healthcare to update
their knowledge on topics related to genetics and genomics that
have an impact in their daily work and apply it usefully in patient
care'. Given the fact that genetics has increasingly become a core
component in a number of specialties, one would think that meeting
this aim for all would be a tall order. This book however
eloquently does so using case examples and key practice points
boxes throughout to demonstrate the clinical application of the
topic under discussion. Another of the book's main strengths is the
way in which it promotes individualised care by enabling the reader
to consider the impact of genetic conditions from the patients'
point of view. Genetics for the Health Sciences brings genetics
into common healthcare settings. It is highly recommended as an
essential text for health care professionals in roles across all
specialties. It is also recommended to students, lecturers, social
scientists; to anyone who has an interest in genetics and wishes to
extend their knowledge. It is a joy to read and could be read from
cover to cover.' Helen Thistlewood, Medical Genetics 'Genetics is
at the forefront of medicine and nurses are expected to have a
basic understanding of the subject. This handbook is well written
and the authors do a good job of making this complex topic
understandable. The book lists prenatal, childhood and adult
genetic conditions that may involve testing and counselling.
Genetic services, types of genetic testing and the impact of
genetic conditions on families are discussed in depth, and case
studies highlight the emotional and psychological needs of patients
and their families. Guidelines for drawing family trees and
practical examples of risk assessment are well explained. The
perspective of the patient regarding risk and lay knowledge is also
considered... All departments should have a copy of this book on
their shelves.' Audrey Ardern-Jones, Nursing Standard
A fundamental and groundbreaking reassessment of how we view and
manage cancer When we think of the forces driving cancer, we don't
necessarily think of evolution. But evolution and cancer are
closely linked because the historical processes that created life
also created cancer. The Cheating Cell delves into this
extraordinary relationship, and shows that by understanding
cancer's evolutionary origins, researchers can come up with more
effective, revolutionary treatments. Athena Aktipis goes back
billions of years to explore when unicellular forms became
multicellular organisms. Within these bodies of cooperating cells,
cheating ones arose, overusing resources and replicating out of
control, giving rise to cancer. Aktipis illustrates how evolution
has paved the way for cancer's ubiquity, and why it will exist as
long as multicellular life does. Even so, she argues, this doesn't
mean we should give up on treating cancer-in fact, evolutionary
approaches offer new and promising options for the disease's
prevention and treatments that aim at long-term management rather
than simple eradication. Looking across species-from sponges and
cacti to dogs and elephants-we are discovering new mechanisms of
tumor suppression and the many ways that multicellular life-forms
have evolved to keep cancer under control. By accepting that cancer
is a part of our biological past, present, and future-and that we
cannot win a war against evolution-treatments can become smarter,
more strategic, and more humane. Unifying the latest research from
biology, ecology, medicine, and social science, The Cheating Cell
challenges us to rethink cancer's fundamental nature and our
relationship to it.
This issue of Clinics in Laboratory Medicine, Guest Edited by
Caroline Astbury, PhD, FACMG, will focus on Cytogenetics, with
topics including: Chronic lymphocytic leukemia; Acute lymphocytic
leukemia; Acute myelogenous leukemia; Chronic myelogenous leukemia;
Plasma cell myeloma; Lymphomas; Solid tumors; Myelodysplastic
syndromes; SNP arrays in clinical practice; Prenatal arrays; FISH
(including Paraffin-embedded (PET) FISH); New and old microdeletion
and microduplication syndromes; Sex chromosome and sex chromosome
abnormalities; Autosomal aneuploidy; Microarray-CGH interpretation
and Genomic Integrity; Structural chromosome rearrangements and
complex chromosome rearrangements; and UPD/imprinting.
This book presents the latest knowledge and the most recent
research results on glycosphingolipid (GSL)-mediated signaling.
GSLs are important constituents of the plasma membrane that exert
their distinct functions through binding to certain functional
proteins. They play a role in various human diseases and also
function as human alloantigens. Cellular GSLs are associated with
many biological functions such as cellular oncotransformation,
phenotype change, neuronal or embryonic development, regulation of
cell division, cell-cell interaction, cell attachment, adhesion,
and motility, and intracellular signaling via protein-carbohydrate
or carbohydrate-carbohydrate interactions. This book opens by
providing the key background on GSL glycan-receptor interactions
and mammalian GSL synthesis. Up-to-date information is then
presented on all aspects of GSL-dependent signaling. Viral protein
and bacterial toxin protein interactions with host cell GSLs are
examined in depth, and the concluding chapter is devoted to
signaling regulation. The book should assist in the further
development of new strategies against emerging infectious agents
and intractable diseases.
How does the genome, interacting with the multi-faceted
environment, translate into the development by which the human
brain achieves its astonishing, adaptive array of cognitive and
behavioral capacities? Why and how does this process sometimes lead
to neurodevelopmental disorders with a major, lifelong personal and
social impact?
This volume of "Progress in Brain Research" links findings on
the structural development of the human brain, the expression of
genes in behavioral and cognitive phenotypes, environmental effects
on brain development, and developmental processes in perception,
action, attention, cognitive control, social cognition, and
language, in an attempt to answer these questions.
Leading authors review the state-of-the-art in their field of
investigation and provide their views and perspectives for future
researchChapters are extensively referenced to provide readers with
a comprehensive list of resources on the topics coveredAll chapters
include comprehensive background information and are written in a
clear form that is also accessible to the non-specialist
Discovered little more than a decade ago, optogenetics - a
revolutionary technique combining genetic and optical methods to
observe and control the function of neurons - is now a widely used
research tool. Optogenetics-driven research has led to insights
into Parkinson's disease and other neurological and psychiatric
disorders. With contributions from leaders and innovators from both
academia and industry, this volume explores the discovery and
application of optogenetics, from the basic science to its
potential clinical use. Chapters cover a range of optogenetics
applications, including for brain circuits, plasticity, memory,
learning, sleep, vision and neurodegenerative and neuropsychiatric
diseases. Providing authoritative coverage of the huge potential
that optogenetics research carries, this is an ideal resource for
researchers and graduate students, as well as for those working in
the biotechnology and pharmaceutical industries and in a clinical
setting.
This issue on psychiatric genetics gives a clinically-minded
approach to the newest thinking in genetics and pharmacogenomics,
including articles on genetic epidemiology; molecular approaches;
epigenetics; and genetic considerations in schizophrenia, bipolar
disorder, major depression, obsessive-compulsive disorder,
alzheimer's disease, autism, ADHD, and addictions. The issue
concludes with articles on diagnostic testing, and
pharmacogenomics.
Fully revised and updated with the most current information, the
third edition of this practical clinical text covers all aspects of
the rapidly advancing field of preimplantation genetic testing
(PGT). Although PGT has become an established procedure for
genetics and assisted reproduction practices over the last decade,
its wider application has occurred after the introduction of next
generation technologies in the last few years, necessitating this
much-needed new edition. This will include, first of all, an update
on PGT accuracy, reliability and safety, to ensure improved access
to PGT for those who may benefit greatly from this technology. New
content will also present progress in the primary prevention of
genetic disorders, which now discusses approaches for prospective
identification of at-risk PGT couples through the application of
the extended gene testing panels. In fact, because of dramatic
technological improvements in all aspects of PGT, most of the
sections have been updated, with the addition of new sections on
next generation technologies and universal PGT with combined
testing for single gene and chromosomal disorders, which has
previously presented a challenge. The guiding PGT strategies for
different genetic disorders are presented, with emphasis on the
most complicated cases that might be of special utility in the
wider application PGT technologies worldwide. Additionally, a new
section will be devoted to borderline indications, which will
include common adult-onset conditions with genetic predisposition
and non-genetic indications, expanding PGT applications to heart
disease and cancer and the use of PGT for stem cell transplantation
treatment of genetic and acquired disorders, where unique outcome
data has become available. Combining the latest research and the
most cutting-edge practice, Practical Preimplantation Genetic
Testing, 3e is an excellent resource for clinical reproductive
medicine specialists, genetic counselors, researchers and analysts.
DNA is under constant challenge from environmental and endogenous
metabolic assaults. Several layers of defence and repair systems
allow cells to maintain stable genomes; in humans, dysfunction of
these systems leads to cancer, neurodegeneration, and other
pathologies. At the same time, recently it had emerged that
targeted and regulated DNA damage and repair is a mechanism
underlying several important cellular processes such as epigenetic
demethylation and immunoglobulin gene diversification. The present
collection of papers is aimed to cover new developments in the area
of protective and regulatory mechanisms associated with DNA damage.
The mechanisms ruling the recognition of damaged nucleotides
against the vast background of normal ones are reviewed. The role
of extended non-catalytic domains that are often found in
eukaryotic DNA repair proteins in contrast to their downsized,
catalytic-only bacterial counterparts is discussed. Among the
proposed subjects are the regulatory functions of bulky covalent
modifications such as poly(ADP)ribosylation and ubiquitylation in
DNA damage response, especially in the context of chromatin
remodelling. As opposed to DNA repair, damage tolerance allows
cells to replicate with lesions in the genome; the enzymes
responsible are also covered. Finally, we present examples of
modern multilevel understanding of the cell function and
malfunction in the wake of genotoxic assaults such as oxidative
stress, abiotic environmental stress, and DNA-damaging plant
toxins.
Unravelling the intricate cell signalling networks and their
significance in cancer poses major intellectual challenge. Keeping
this in mind, the book aims at understanding the mechanism of
action of different proteins and their complexes in the cancer
signalling pathways. Hence, the proposed book that comprises 20
chapters provides a comprehensive introduction on cell signalling,
its alterations in cancer, molecules that have been popular targets
as well as the ones that are emerging as targets. In addition, it
discusses different forms of therapy that are coming up for its
treatment. Other than that, a major portion of the book is focused
on studying different disciplines at the interface of biology and
other areas of science that are being used to understand cancer
biology in depth.
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