This first volume of a two-volume set describes general aspects, such as the historical view on the topic, the role of information distribution and preparedness of health-care systems and preparedness in emergency cases. Part two describes and discusseses in detail the pathogens and toxins that are potentially used for biological attacks. As such, the book is a valuable resource for faculties engaged in molecular biology, genetic engineering, neurology, biodefense, biosafety & biosecurity, virology, and infectious disease programs, as well as professional medical research organizations.

Immunology of Infection, 2nd Edition, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the Microbiologist interested in analysing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology.
This new edition of Immunology of Infection provides ready-to-use "recipes," and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition.
Methods in Microbiologyis the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your research.
Key Features:
* Includes techniques for genome-wide expression profiling of both the pathogen and host and of the host response to infection
* Cytometric analysis of cytokine secretion by immune cells
* Describes tetramer technology for the quantitative analysis of antigen specific T cell responses
* analysis of host cells and pathogens involved in the host-microbe interplay
* Covers techniques useful for the analysis of human and murine systems
* Includes techniques for the prediction and determination of MHC ligands and T cell epitopes
* Covers the fundamentals and practice of DNA vaccines
* Describes methods for the isolation and propagation of human dendritic cells

Thousands of different microbial species colonize the human body, and are essential for our survival. This book presents a review of the current understanding of human microbiomes, the functions that they bring to the host, how we can model them, their role in health and disease and the methods used to explore them. Current research into areas such as the long-term effect of antibiotics makes this a subject of considerable interest. This title is essential reading for researchers and students of microbiology.

Chronic Hepatitis C virus (HCV) infection is a serious condition affecting over 180 million people world-wide. The virus infects the liver and while it is estimated that 20% of those infected clear the virus spontaneously, the virus persists in the majority of individuals leading to liver fibrosis, cirrhosis, and hepatocellular carcinoma. This book presents topical research in the study of the epidemiology, pathogenesis and treatment of Hepatitic C Virus including: genome-wide association studies regarding HCV infection; hepatic and blood dendritic cell subsets in patients with chronic HCV; bone metabolism disorders in HCV infection; Socs1 involvement in liver damage during HCV infection; asymptomatic low-level HCV persistence; and HCV infection as the leading cause of liver disease in renal transplant recipients.

The discovery of new and previously unknown organisms that cause foodborne illness makes it essential for scientists, regulators, and those in the food industry to reconsider their traditional approaches to food preservation. A single source reference that can provide the latest practical information on how to deal with the range of probiotic health issues that have recently arisen would be invaluable to have. Probiotics in Food Safety and Human Health is that resource. It presents an in-depth characterization and diagnosis of probiotic strains and their mechanisms of action in humans, explains the role food applications have in the development of new products that guard against gastrointestinal diseases, and addresses the current regulatory environment. The material in each chapter is written in an accessible format by internationally renowned experts and includes citations from scientific literature. Highlights include a thorough discussion of probiotic issues such as pre- and postharvest food safety applications of probiotics, genetic engineering, and probiotic identification. The book also presents information on new regulations and emerging trends in the two major probiotics markets in the world, Europe and Japan. Unique in its depth and breadth of scope, Probiotics in Food Safety and Human Health provides vital information to those who need to be knowledgeable of the functional properties of foods aimed at improving human health.

'Get colouring and let yourself be inspired by the marvels of the microscopic world as you make your way through this fascinating and important book.' Professor Luke O'Neill This distinctive colouring book explores the beauty of microscopic life, from vaccines and viruses to protozoa and algae. Go on a journey of scientific discovery as your colours illuminate a hidden world beyond the limits of our own vision. Bring to life the nucleocapsid protein of the Covid-19 virus, the overlapping frill of the delphinium peregrinum seed and the shell-like carapace of a water-flea as you discover the startling and unexpected beauty of life under the lens. Containing over 60 detailed illustrations from the natural world, including a coronavirus vaccine on the cover and inside, this book is a calming celebration of small science.

Pathology and Pathogenesis of Human Viral Disease is a comprehensive reference that examines virus-induced clinical disease of humans in the context of the responsible virus and its epidemiology. Encompassing everything from cold and flu viruses to sexually transmitted diseases, this important resource describes the cellular and tissue pathological changes attributable to infection in the context of the pathogenic mechanisms involved. The author provides a comprehensive review of the older and contemporary literature, considering both the common and much rarer complications of infection.
Pathology and Pathogenesis of Human Viral Disease is written from the unique perspective of the clinical pathologist. It will help clinicians and pathologists gain a better understanding of changes that occur in viral infected cells, tissues, and organs. It will also serve as a pathology source book for virologists, internists, and pediatricians.
Key Features
* Provides a comprehensive, worldwide perspective of viral disease pathology
* Bridges the fields of pathology and virology; integrating clinical disease with cell and tissue pathology
* Addresses topics from the perspective of the clinical pathologist
* Illustrates unique, viral induced pathological lesions
* Considers common and uncommon complications of infection

This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Understand the clinically relevant aspects of microbiology with this student-acclaimed, full-color review --- bolstered by case studies and hundreds of USMLE (R)-style review questions Since 1954, Jawetz, Melnick & Adelberg's Medical Microbiology has been hailed by students, instructors, and clinicians as the single-best resource for understanding the roles microorganisms play in human health and illness. Concise and fully up to date, this trusted classic links fundamental principles with the diagnosis and treatment of microbial infections. Along with brief descriptions of each organism, you will find vital perspectives on pathogenesis, diagnostic laboratory tests, clinical findings, treatment, and epidemiology. The book also includes an entire chapter of case studies that focuses on differential diagnosis and management of microbial infections. Here's why Jawetz, Melnick & Adelberg's Medical Microbiology is essential for USMLE (R) review: *640+ USMLE-style review questions *350+ illustrations *140+ tables*22 case studies to sharpen your differential diagnosis and management skills *An easy-to-access list of medically important microorganisms *Coverage that reflects the latest techniques in laboratory and diagnostic technologies *Full-color images and micrographs *Chapter-ending summaries *Chapter concept checks Jawetz, Melnick & Adelberg's Medical Microbiology, Twenty-Eighth Edition effectively introduces you to basic clinical microbiology through the fields of bacteriology, mycology, and parasitology, giving you a thorough yet understandable review of the discipline. Begin your review with it and see why there is nothing as time tested or effective.

Volume 3 of "Advances in Antiviral Drug Design" is keeping up with the recent progress made in the field of antiviral drug research and highlights five specific directions that have opened new avenues for the treatment of virus infections.
"First," the use of lamivudine (3TC) for the treatment of HIV infections, and its more recent introduction for the treatment of hepatitis B virus (HBV) infections, has heralded the transition of D- to L-nucleosides in the antiviral nucleoside drug design, and it is likely that the future will provide more nucleosides of the L-configuration, such as (-)FFC (emtricitabine) and L-FMAU, as will be described by J.-C.G. Graciet and R.F. Shinazi.
"Second," the acyclic purine nucleoside phosphonates, i.e. PMEA (adefovir and PMPA (tenofovir), offer great potential as both anti-HIV and anti-HBV agents, and both compounds have been the subject of advanced clinical trials in their oral produrg form (adefovir dipivoxil and tenofovir disoproxyl), as mentioned by M.N. Arimilli, J.P. Dougherty, K.C. Cundy, and N. Bischofberger.
"Third," with the advent of nevirapine, delavirdine, and efavirenz, the NNRTIs have definitely come of age. Emivirine (MKC-442), a derivative of the original HEPT analog that was described in 1989 has now proceeded through pivotal clinical studies, and how this class of compounds evolved is presented in the account of H. Tanaka and his colleagues.
"Fourth," at the end of 1999, anticipating on the next winter influenza offensive, we should have at end two compounds that specifically inhibit influenza A and B virus infections: zanamivir (by the intranasal route) and oseltamivir (by the oral route). Both compounds have proved effective in the prophylaxis and treatment of influenza A and B virus infections and act through the same mechanism; that is by blocking the viral neuraminidase (or sialidase), a key enzyme that allows the virus to spread from one cell to another (within the respiratory mucosal tract). The design of these sialidase inhibitors will be presented by M. von Itzstein and J.C. Dyason.
"Fifth," the discovery (in 1996) of the chemokine receptors CXCR4 and CCR5 as essential coreceptors (in addition to the CD4 receptor) for HIV entry into the cells, has boosted an enormous interest in potential antagonists of these receptors. The bicyclams represent the first low-molecular-weight compounds targeted at CXCR4, the coreceptor used by the more pathogenic, T-lymphotropic, HIV strains, to enter the cells. They will be addressed by G.J. Bridger and R.T. Skerlj.
The five topics covered in this third volume of "Advances in" "Antiviral Drug Design" are in the front line of the present endeavors towards the chemotherapy of virus infections. They pertain to the combat against three of the most important virus infections of current times: HIV, HBV, and influenza virus.

Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for "in vivo" efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections.
Key Features
* Discusses ethical and safety aspects in an introductory background section
* Covers principles of animal care and current techniques appropriate for the use of animal models of infection
* Details a wide range of animals including rodents, rabbits, cats, and primates
* Provides hands-on descriptions of how to set up the model
* Discusses the major advantages and limitations of each model
* Ensures full coverage of bacterial, fungal, viral, and parasitic infections

In May 1993, a cluster of cases of a lethal disease among healthy young people brought the attention of the world to the southwestern deserts. A previously unknown disease was killing up to 80% of the people it infected.
The reaction in the area and across the nation mixed fear, lack of information, and the struggles of doctors to save the victims of an unknown killer with hard science and the age old rhythmns of the desert. What came out was the story of a virus that had been killing since man arrived in the American continents, Hantavirus, with deadly relatives across the Americas and across the world. This book explains why and how the virus kills, and why it is still killing today. Why all of the science aimed at a virus identified back in 1993 has not brought a vaccine or a cure is part of the story, as is how that killer virus fits into the story of "new" diseases across the world.
The story of hantavirus disease, what has happened since that first outbreak, and what the real risks are is laid out by an experienced scientist and an award winning journalist living and working in the area of the 1993 outbreak.
Key Features
* Covers the full story of the recent hantavirus outbreak
* Includes interviews with survivors, and local reaction
* Presents the science in lay terms
* Places the event in the broader context of emerging diseases worldwide
* The only account which takes the reader beyond the initial outbreak in 1993-1994, bringing them up to late 1998
* Discusses hantavirus disease in the U.S., Argentina, and Canada

HIV and the New Viruses presents cutting-edge reviews of persistent human virus infections as a coherent collection for the first time. These cover recently discovered viruses such as HHV-6, HHV-8 and HCV, as well as the latest research on HIV.
This comprehensive and updated reference includes an in-depth study of the major issues in the epidemiology, pathogenicity, molecular virology, host responses and management of conditions associated with those viruses. Information on new pharmaceuticals and vaccine developments is also included.
Edited by the leading experts in the field, HIV and the New Viruses will be essential reading for postgraduates, clinicians and researchers in virology, immunology, cancer, molecular biology and the pharmaceutical industry.
Key Features
* Presents cutting-edge reviews of persistent human virus infections as a coherent collection for the first time
* Includes an in-depth study of the major issues in the epidemiology, pathogenicity, molecular virology, host responses, and management of conditions associated with those viruses

Established for almost 30 years, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research.
Immunology of Infection, edited by two of the foremost figures in the field, presents the most appropriate, up-to-date techniques in the detail you require. The layout is structured for ease of reference, and the volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology, and parasitology.
The new volume provides a carefully selected collection of immunological techniques for the microbiologist wishing to study host-pathogen relationships "in vivo" and "in vitro." This multi-authored book has succeeded in bringing together experts from various fields of molecular and cellular immunology who provide ready-to-use recipes for the "ex vivo" and "in vitro" analysis of anti-infective immunity.
Key Features
* Focuses on the methods most useful for the microbiologist interested in analysing host-pathogen relationships
* Ready-to-use, tried and tested recipes
* Lists of suppliers provided as appendices to each chapter
* Covers techniques useful for the analysis of human and murine cells
* Includes techniques for the prediction and determination of MHC ligands and T cell epitopes
* Describes the art and science of DNA vaccines
* Essential methods for measuring human cytokine responses
* Covers isolation and propagation of dendritic cells

This title includes proceedings of the Conference Held in Bergamo on 13-14 June 1988.

The book is a compilation of research work carried out on plant viruses during past 100 years in India. Plant viruses are important constraints in Indian agriculture. Tropical and sub-tropical environments and intensive crop cultivation practices ideally favours perpetuation of numerous plant viruses and their vectors in India, which often cause wide spread crop losses. Of all the plant pathogens, studies of plant viruses have received a special attention as they are difficult to manage. A large body of literature has been published on the plant virus research from India during past 100 years; however the information is so far not available in one place. This book provides comprehensive information on the biology, molecular biology, epidemics, crop losses, diagnosis and management of viruses and viroids occurring in India. Description of properties of the viruses are provided in the chapters comprising of different genera such as Allexivirus, Begomovirus, Babuvirus, Badnavirus, Carlavirus, Carmovirus, Cucumovirus, Closterovirus, Ilavirus, Mandrivirus, Potyvirus, Tospovirus, Tungrovirus and Sobemovirus. Virus-vector research related to aphid, thrips and whitefly is discussed. The work on the management aspects of plant viral diseases has been described with reference to the conventional, antiviral and transgenic approaches. Further, the quarantine mechanism developed in India for the exclusion of viruses and vectors has also been included. The book also provides useful information about the capacity building on the research and education on Plant Virology in India. Overall, the book covers a wide range of accounts of research findings and innovations in Plant Virology in India during past 100 years. The book will be a resourceful reference to the students, scientists, agricultural professionals and policy makers.

Everything readers ever wanted to know about deadly viruses, killer parasites, flesh-eating microbes, and other lifethreatening beasties but were afraid to ask

What disease, known as the White Death has killed 2 billion people, and counting?

What fatal disease lurks undetected in air conditioners and shower heads, waiting to become airborne?

How lethal is the Ebola virus, and will there ever be a cure for it?

How do you catch flesh-eating bacteria?

Killer Germs takes readers on a fascinating (sometimes horrifying) journey into the amazing world of viruses, bacteria, protozoa, fungi, and worms and explores the roles they have played in shaping the course of human history. From biblical plagues, to the AIDS crisis, to supergerms of the future, this updated and revised edition of the original covers the whole gamut of diseases that have threatened humanity since its origins.

It also includes a new chapter on the history of bioterrorism and the deplorable role it has played and is likely to play in the phenomenal diversity of diseases.

This book is a one-stop reference resource, presenting recent research in various emerging areas of microbiology, including microbial biotechnology, microbes in health, microbial interactions, agricultural microbiology and computational approaches. Recent discoveries in microbiology have created a great deal of interest among researchers around the globe, and as as such the book discusses a number of important research topics, such as microbial enzymes and nanoparticles, bacterial polyhydroxyalkanoates, biosurfactant aided bioprocessing, autophagy and microbial pathogenesis, multidrug resistant bacteria, probiotics, rhizosphere, metal tolerant bacteria, plant- beneficial environmental bacteria and therapeutic applications of fungal chondroitinase. It serves as a valuble resource for masters, doctoral and postdoctoral researchers in life sciences, as well as scientists involved in various interdisciplinary research areas. It also provides useful material for higher-level graduate courses in microbiology and biotechnology.

Published in a modern, user-friendly format this fully revised and updated edition of The Handbook of Protoctista (1990) is the resource for those interested in the biology, diversity and evolution of eukaryotic microorganisms and their descendants, exclusive of animals, plants and fungi. With chapters written by leading researchers in the field, the content reflects the present state of knowledge of the cell and genome biology, evolutionary relationships and ecological/medical/economic importance each major group of protists, organized according to current protist systematics as informed by molecular phylogenetics and genomics.

Bacterial pili play important roles as environmental sensors, in host colonization and in biofilm formation, enabling bacteria to interact with the environment, with surfaces and with other bacteria and host cells. Most bacteria, both Gram positive and Gram negative, and almost all bacterial pathogens, are piliated. This book discusses the synthesis, structure, evolution, function and role in pathogenesis of these complex structures, and their basis for vaccine development and therapeutics for Streptococcus pathogens. It is an invaluable resource for researchers and students of medical microbiology.

Molecular diagnostic procedures have been described in a number of recent books and articles. However, these publications have not focused on virus detection, nor have they provided practical protocols for the newer molecular methods.
Written by the inventors or principal developers of these technologies, Molecular Methods for Virus Detection provides both reviews of individual methods and instructions for detecting virus nucleic acid sequences in clinical specimens. Each procedure includes quality assurance protocols that are often ignored by other methodology books. Molecular Methods for Virus Detection provides clinically relevant procedures for many of the newer diagnostic methodologies.
Key Features
* Provides state-of-the-art PCR methods for amplification, quantitation, " in situ" hybridization, and multiplex reactions
* Goes beyond PCR with protocols for 3SR, NASBA, LCR, SDA, and LAT
* Covers important virus detection methods such as "in situ" hybridization; Southern, dot, and slot blots; branched chain signal amplification; and chemiluminescence
* Includes quality control information crucial in research and clinical laboratories
* Most chapters are written by the inventors and principal developers of the methodologies
* Includes color plates, 77 figures, and 18 tables

For courses in Microbiology Lab and Nursing and Allied Health Microbiology Lab A Flexible Approach to the Modern Microbiology Lab Easy to adapt for almost any microbiology lab course, this versatile, comprehensive, and clearly written manual is competitively priced and can be paired with any undergraduate microbiology text. Known for its thorough coverage, straightforward procedures, and minimal equipment requirements, the Eleventh Edition incorporates current safety protocols from governing bodies such as the EPA, ASM, and AOAC. The new edition also includes alternate organisms for experiments for easy customisation in Biosafety Level 1 and 2 labs. New lab exercises have been added on Food Safety and revised experiments, and include options for alternate media, making the experiments affordable and accessible to all lab programs. Ample introductory material, engaging clinical applications, and laboratory safety instructions are provided for each experiment along with easy-to-follow procedures and flexible lab reports with review and critical thinking questions.

This second one of a two volume set will be of interest to medical microbiologists, practitioners, medical students and other health care providers who are engaged in management and treatment of pediatric viral infections. New evidence on topics related to better clinical management of patients is presented. The book may double as a clinical guide to care with algorithms, Practice Points and photographs and therefore aid the clinical decision making in management of sick children.

Innovative Food Analysis presents a modern perspective on the development of robust, effective and sensitive techniques to ensure safety, quality and traceability of foods to meet industry standards. Significant enhancements of analytical accuracy, precision, detection limits and sampling has expanded the practical range of food applications, hence this reference offers modern food analysis in view of new trends in analytical techniques and applications to support both the scientific community and industry professionals. This reference covers the latest topics across existing and new technologies, giving emphasis on food authenticity, traceability, food fraud, food quality, food contaminants, sensory and nutritional analytics, and more.

1st Prize, 'New Authored Books' category, Royal Society of Medicine and Society of Authors Medical Book Awards 2008

""Overall, I am impressed by the up-to date information content and structure provided in Bacteriology of Humans. It is truly an ecological perspective helpful for undergraduate/graduate majors in microbiology and immunology."" -American Society for Microbiology, June 2009

""Wilson provides the reader with an up-to-date, comprehensive census of the indigenous microorganisms that inhabit the human body and in so doing contributes significantly to this rapidly advancing area of study. The narrative is clearly written; the index is excellent; there are numerous bibliographic citations. Each chapter is rich with tables, diagrams, color micrographs, and charts ... Highly recommended."" -Choice Reviews

""This comprehensive, yet accessible text... is an excellent and informative reference book... it should be on the shelf of every major science and medical library. The content, organization, and presentation make this book a unique resource."" -Doody's Book Reviews

Until recently, the indigenous microbiota of humans has been a relatively neglected area of microbiology with most attention being focused on those microbes that cause disease in humans, rather than on those that co-exist with us in the disease-free state. However, in the past decade research has shown that not only is the indigenous microbiota involved in protecting humans from exogenous pathogens but it is also involved in our development and nutrition. Consequently, interest has grown substantially among health professionals and scientists in analyzing and understanding these microbial (largely bacterial) communities.

This comprehensive, yet accessible text provides an up-to-date guide to the development, composition and distribution of indigenous microbial communities of humans. With the aid of abundant colour figures, diagrams, tables and maps, it establishes links between the physicochemical factors prevailing at an anatomical site and the types of microbes to be found there. The book includes an introduction to the human-microbe symbiosis as well as an in-depth look at the main systems and organs of the human body that have an indigenous microbiota. Each chapter includes a list of references for further study.

This is an excellent and informative reference book that is useful to anyone with an interest in microbiology, medical microbiology, microbial ecology, infectious diseases, immunology, human biology, medicine, dentistry, nursing, health sciences, biomedical sciences or pharmacy - it should be on the shelf of every major science and medical library.

Hallmark Features: Provides a comprehensive, yet accessible, reference book on the human microbiotaLavishly illustrated with colour figures, diagrams, tables and mapsEach chapter provides a list of references to promote further studyEach chapter contains links to key websitesOffers an ecological approach that explains why certain organisms are associated with a particular anatomical site